763 results match your criteria Spinal Imaging in Astrocytoma

Cerebrospinal Fluid Drop Metastases of Canine Glioma: Magnetic Resonance Imaging Classification.

Front Vet Sci 2021 3;8:650320. Epub 2021 May 3.

Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, United States.

Dissemination of glioma in humans can occur as leptomeningeal nodules, diffuse leptomeningeal lesions, or ependymal lesions. Cerebrospinal fluid (CSF) drop metastasis of glioma is not well-recognized in dogs. Ten dogs with at least two anatomically distinct and histologically confirmed foci of glioma were included in this study. Read More

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Intramedullary spinal cord lesions in children.

J Pak Med Assoc 2021 Feb;71(2(B)):775-777

Section of Neurosurgery, Department of Surgery, Aga Khan University Hospital, Karachi.

Paediatric intramedullary spinal cord lesions are uncommon pathologies, prone to result in dismal prognosis if not managed promptly and aggressively. While children usually present in good functional grades compared to adults, early recognition and treatment is important to improve outcomes. In this review, we present tumour demographics, patient factors, and treatment modalities of intramedullary spinal cord lesions in paediatric patients. Read More

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February 2021

Refining the treatment of spinal cord lesions: experience from 500 cases.

Neurosurg Focus 2021 May;50(5):E22

Objective: Tumorous lesions of the spinal cord, as well as some vascular lesions like cavernous hemangiomas, demand careful consideration as to the indication and approach for surgery. As these lesions are rare in any departmental series, refinement of treatment strategies evolves over long periods. In this context, the authors evaluated a series of 500 intramedullary lesions for approach, technique, outcome, complications, and follow-up. Read More

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High-grade astrocytoma with piloid features (HGAP): the Charité experience with a new central nervous system tumor entity.

J Neurooncol 2021 May 27;153(1):109-120. Epub 2021 Apr 27.

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Radiation Oncology, Charitéplatz 1, 10117, Berlin, Germany.

Purpose: High-grade astrocytoma with piloid features (HGAP) is a recently described brain tumor entity defined by a specific DNA methylation profile. HGAP has been proposed to be integrated in the upcoming World Health Organization classification of central nervous system tumors expected in 2021. In this series, we present the first single-center experience with this new entity. Read More

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Challenges in diagnosis and management of adult spinal cord gliomas.

Rev Neurol (Paris) 2021 May 23;177(5):515-523. Epub 2021 Apr 23.

Hôpital de la Timone, Marseille, France.

Intramedullary spinal cord gliomas have very low incidence rates. They are associated with difficulties in diagnosis and treatment, and cause significant morbidity. Their clinical presentation and their appearance at magnetic resonance imaging are not specific. Read More

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Multicentric Spinal Pilocytic Astrocytoma Presenting with Syringomyelia.

Cureus 2021 Feb 15;13(2):e13353. Epub 2021 Feb 15.

Paediatric Neurosurgery, Asan Medical Center, Seoul, KOR.

Pilocytic spinal cord astrocytomas make up 21% of intramedullary tumors. Only 20% of those tumors are associated with syringomyelia. To our knowledge, this is the first report of an adult presenting with multiple spinal pilocytic astrocytomas associated with syringomyelia. Read More

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February 2021

Surgical and Radiologic Prognostic Factors in Intramedullary Spinal Cord Lesions.

World Neurosurg 2021 Jun 19;150:e550-e560. Epub 2021 Mar 19.

Department of Neurosurgery and Gamma Knife Radiosurgery, I.R.C.C.S. San Raffaele Hospital, Milan, Italy. Electronic address:

Objective: The present study aimed to perform a comprehensive data analysis of 47 consecutive patients treated in 8 years and to observe how clinical, radiologic, and surgical factors affect early and long-term outcomes, recurrence rate, and survival.

Methods: Clinical, radiologic, and surgical data were collected retrospectively from the review of a prospectively collected database. The neurologic disability was evaluated according to the modified Rankin Scale (mRS). Read More

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Concomitant KIAA1549-BRAF fusion and IDH mutation in Pediatric spinal cord astrocytoma: a case report and literature review.

Brain Tumor Pathol 2021 Apr 28;38(2):132-137. Epub 2021 Feb 28.

Department of Pathology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Primary tumors of the spinal cord are rare, accounting for 3-6% of tumors in the central nervous system, particularly in children. KIAA1549-BRAF fusion is more common in pilocytic astrocytoma (PA) and IDH1 R132H mutation is rare in infratentorial tumors. Here, we report a 10-year-old male patient who presented with weakness in lower limbs that progressed to difficulty walking. Read More

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[Spinal tumors].

Radiologe 2021 Mar 11;61(3):267-274. Epub 2021 Feb 11.

Klinik für Diagnostische und Interventionelle Neuroradiologie, Klinikum Bremen-Mitte/Bremen-Ost, 28205, Bremen, Deutschland.

Spinal tumors are often classified into three anatomical compartments on the basis of their relationship to the dural space and myelon. The most common primary spinal neoplasms are glial tumors (ependymoma, astrocytoma), nerve sheath tumors (schwannoma, neurofibroma) and meningioma. Metastases represent another common tumor entity and can occur in every spinal compartment. Read More

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Long-Term Outcomes of Intra-Arterial Chemotherapy for Progressive or Unresectable Pilocytic Astrocytomas: Case Studies.

Neurosurgery 2021 03;88(4):E336-E342

Department of Neurology, Oregon Health & Science University, Portland, Oregon.

Background: Progressive and/or unresectable pilocytic astrocytomas (PAs) carry a poor prognosis compared to typical PA. Early radiotherapy (RT) may have severe long-term neurocognitive side effects in this patient population. Intra-arterial (IA) chemotherapy is a viable alternative or addition to intravenous (IV) chemotherapy, which may be beneficial in avoidance of early RT. Read More

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Intramedullary clear cell ependymoma of the lower thoracic spinal cord: report of a new case.

Surg Neurol Int 2020 11;11:423. Epub 2020 Dec 11.

Faculty of Medicine, Universidad Autonoma de Sinaloa, Culiacan, Sinaloa, Mexico.

Background: Clear cell ependymomas (CCEs) are a rare variant of tumors of the nervous system, the main location is the intracranial compartment. Special differential diagnosis should be done with oligodendrogliomas, neurocytoma, glioneurocytoma, astrocytoma, or metastatic renal cell carcinoma, lesions that somehow share cells with clear cytoplasm. Most of these lesions are benign but differential diagnosis is essential to decide further treatment. Read More

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December 2020

Radiation-induced glioblastoma of the conus medullaris from radiation treatment of cervical cancer.

BMJ Case Rep 2020 Dec 17;13(12). Epub 2020 Dec 17.

Department of Laboratories, College of Medicine and Philippine General Hospital, University of the Philippines-Manila, Manila, Philippines.

Radiation-induced spinal glioblastoma is an extremely rare disease with only four previously published reports in the literature. We report the fifth case, a 69-year-old woman who previously underwent treatment with brachytherapy for cervical cancer, and thereafter presented with neurologic deficits from a conus medullaris tumour. Biopsy and histopathology confirm glioblastoma, not otherwise specified. Read More

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December 2020

[Visual fluorescence combined with laser spectroscopy in surgery for intramedullary spinal cord tumors].

Zh Vopr Neirokhir Im N N Burdenko 2020 ;84(6):5-14

Burdenko Neurosurgical Center, Moscow, Russia.

Background: Surgical treatment of intramedullary spinal cord tumors is aimed at total resection of tumor with maximum preservation of neurological and functional status. In some cases, intramedullary tumors have unclear dissection plane or gliosis zone. This area is not a tumor and does not require resection. Read More

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December 2020

MRI characteristics and resectability in spinal cord glioma.

Clin Neurol Neurosurg 2021 01 19;200:106321. Epub 2020 Oct 19.

Department of Neurosurgery, University of Iowa Carver College of Medicine, Iowa City, IA USA. Electronic address:

Objective: The histopathology of intramedullary spinal cord tumors (IMSCT) can be suspected from the MRI features and characteristics. Ultimately, the confirmation of diagnosis requires surgery. This retrospective study addresses MRI features including homogeneity of enhancement, margination, and associated syrinx in intramedullary astrocytomas (IMA) and ependymomas (IME) that assist in diagnosis and predict resectability of these tumors. Read More

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January 2021

FDG PET/CT in Recurrent Glioblastoma Multiforme With Leptomeningeal and Diffuse Spinal Cord Metastasis.

Dharmender Malik

Clin Nucl Med 2021 Feb;46(2):138-139

From the Department of Nuclear Medicine and PET/CT, Paras Hospitals, Gurugram, Haryana.

Abstract: Glioblastoma multiforme is one of the most common malignant types of tumor arising from the central nervous system known for its devastating intracranial progress and dismal prognosis. Macroscopically evident and symptomatic spinal cord metastasis detected with FDG PET/CT imaging is a rare event. We present a rare case of symptomatic diffuse spinal metastases of glioblastoma multiforme in a 25-year-old woman, who has been previously treated surgically with gross tumor resection followed by adjuvant radiotherapy and chemotherapy with temozolomide. Read More

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February 2021

Extracranial Metastasis of IDH-1 Wild Type Glioblastomas.

Turk Neurosurg 2021 ;31(1):24-30

Adana City Training and Research Hospital, Department of Neurosurgery, Adana, Turkey.

Aim: To identify the effects of different immunohistochemical features of glioblastomas with spinal metastases based on the metastatic spread and survival rate.

Material And Methods: A total of 214 patients who were diagnosed with and operated for brain tumor in our clinic between 2007 and 2018, and pathologically diagnosed with glioblastoma were retrospectively evaluated. Among them, 141 medical records were reviewed, and 23 of them underwent spinal magnetic resonance imaging postoperatively due to various complaints. Read More

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MR imaging findings in primary spinal cord glioblastoma.

Radiol Case Rep 2021 Jan 2;16(1):72-77. Epub 2020 Nov 2.

Section of Neuroradiology, Department of Radiology, Vall d'Hebron University Hospital, Hospital Vall d'Hebron, Passeig de la Vall d'Hebron, 119-129 | 08035, Barcelona, Spain.

Spinal cord glioblastoma is a rare disease, with an aggressive course and a poor prognosis. We describe magnetic resonance imaging (MRI) findings, in 3 adult cases of biopsy-confirmed glioblastoma. Conventional MRI findings were unclear with regard to the differential diagnosis between this rare tumor and other more common spinal cord lesions, including less aggressive tumors such as ependymoma or pilocytic astrocytoma, abscesses or tumefactive demyelinating lesions. Read More

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January 2021

Intramedullary spinal cord ganglioglioma: Case report and comparative literature review.

Neurocirugia (Astur : Engl Ed) 2021 May-Jun;32(3):124-133. Epub 2020 Oct 20.

Departamento de Neurocirugía, Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de Gran Canaria, Las Palmas, España.

Introduction: Intramedullary spinal cord gangliogliomas (ISCGGs) account for 35-40% of all intramedullary tumors in children. These tumors have a different algorithm for treatment and prognosis than other medullary tumors, such as astrocytomas and spinal ependymomas. The objective of the study was to review the literature and examine an approach to diagnosing and treating this tumor based on a case report of ISCGG diagnosed at our center. Read More

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Discovery of a dual inhibitor of NQO1 and GSTP1 for treating glioblastoma.

J Hematol Oncol 2020 10 21;13(1):141. Epub 2020 Oct 21.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.

Background: Glioblastoma (GBM) is a universally lethal tumor with frequently overexpressed or mutated epidermal growth factor receptor (EGFR). NADPH quinone oxidoreductase 1 (NQO1) and glutathione-S-transferase Pi 1 (GSTP1) are commonly upregulated in GBM. NQO1 and GSTP1 decrease the formation of reactive oxygen species (ROS), which mediates the oxidative stress and promotes GBM cell proliferation. Read More

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October 2020

Clinical characteristics and long-term surgical outcomes of spinal pilocytic astrocytoma: a report of twenty cases.

Acta Neurochir (Wien) 2020 Oct 10. Epub 2020 Oct 10.

Medical School of Nankai University, No. 94, Weijin Road, Naikai District, Tianjin, 300071, People's Republic of China.

Background: Primary spinal pilocytic astrocytoma (PA) is an extremely rare low-grade astrocytoma with unclear natural history. The demographic characteristics, imaging features, and long-term surgical outcomes have not been clarified due to low prevalence and limited reports.

Methods: A retrospective review within a single institution between 2004 and 2018 of all patients with pathologically proven PA was conducted. Read More

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October 2020

[Diffuse Leptomeningeal Glioneuronal Tumor with Subarachnoid Hemorrhage:A Case Report].

No Shinkei Geka 2020 Sep;48(9):801-808

Department of Neurosurgery, Faculty of Medicine, Yamagata University.

Diffuse leptomeningeal glioneuronal tumor(DLGNT)is a rare primary neoplasm of the central nervous system, and is a condition that is newly listed in the 2016 World Health Organization(WHO)classification of tumors of the central nervous system. We report an adult case of DLGNT that was characteristically merged with subarachnoid hemorrhage. A 46-year-old woman reported persistent dizziness upon walking. Read More

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September 2020

Glioblastoma Multiforme: A Rare Case of Spinal Drop Metastasis.

World Neurosurg 2020 12 18;144:24-27. Epub 2020 Aug 18.

Department of Neurosurgery, University Hospital of North Midlands, NHS Trust, Stoke-on-Trent, United Kingdom.

Background: The occurrence of spinal drop metastasis in patients diagnosed with glioblastoma multiforme (GBM) is rare. In previous reports, this diagnosis occurred after surgical resection of GBM, which was believed to increase the likelihood of tumor seeding. Diagnosis of spinal drop metastasis prior to surgery remains rare. Read More

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December 2020

Multicentric Exophytic Primary Spinal Cord Glioblastoma Mimicking Teratoma.

World Neurosurg 2020 12 8;144:262-263.e2. Epub 2020 Aug 8.

School of Clinical Medicine, Tsinghua University, Beijing, China; Department of Neurosurgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China. Electronic address:

Primary spinal cord glioblastoma is an extremely rare disease that shows dismal prognosis. Here we report the first case, to our knowledge, of multicentric primary spinal cord glioblastoma presenting with exophytic involvement mimicking teratoma. A 12-year-old girl presented to our hospital with a 6-month history of back pain and progressive paraplegia. Read More

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December 2020

Clinical, radiological and molecular characterization of intramedullary astrocytomas.

Acta Neuropathol Commun 2020 08 8;8(1):128. Epub 2020 Aug 8.

Department of Pathology, Erasme University Hospital, Université Libre de Bruxelles (ULB), 808 Route de Lennik, B-1070, Brussels, Belgium.

Intramedullary astrocytomas (IMAs) are rare tumors, and few studies specific to the molecular alterations of IMAs have been performed. Recently, KIAA1549-BRAF fusions and the H3F3A p.K27M mutation have been described in low-grade (LG) and high-grade (HG) IMAs, respectively. Read More

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[Spinal cord metastasis of anaplastic oligodendroglioma of the brain without recurrence of primary tumor. Ccase report and literature review].

Zh Vopr Neirokhir Im N N Burdenko 2020 ;84(4):54-60

Burdenko Neurosurgical Center, Moscow, Russia.

Spinal cord metastases of brain gliomas are rare. However, incidence of these tumors has been increasing recently. The vast majority of neurosurgeons and oncologists recognize spinal cord metastasis of malignant brain glioma followed by symptoms of transverse spinal cord lesion as non-curable terminal stage of malignant process. Read More

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September 2020

Clinical Features and Outcomes of Primary Spinal Cord Glioblastoma: A Single-Center Experience and Literature Review.

World Neurosurg 2020 11 18;143:e157-e165. Epub 2020 Jul 18.

School of Clinical Medicine, Tsinghua University, Beijing, China; Department of Neurosurgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China. Electronic address:

Objective: We aim to elucidate the clinical characteristics of patients with primary spinal cord glioblastoma (PSC GBM) and prognostic factors for their outcomes.

Methods: A cohort of 11 patients with pathologically diagnosed PSC GBM from our center were retrospectively reviewed. The clinical, radiologic, operative, and molecular information were recorded, and univariate analysis was performed to identify prognostic factors. Read More

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November 2020

Radiologic-Histopathologic Correlation of Adult Spinal Tumors: A Retrospective Study.

Asian J Neurosurg 2020 Apr-Jun;15(2):354-362. Epub 2020 May 29.

Department of Neurosurgery, University of Health Sciences, Bakirköy Research and Training Hospital for Neurology Neurosurgery, and Psychiatry, Istanbul, Turkey.

Aim: Preoperatively performed magnetic resonance images (MRIs) are essential before treating spinal tumors surgically. This study aims to investigate the compatibility of MRI preliminary diagnosis and proven histopathologic diagnosis of consecutively operated 96 spinal tumors.

Material And Methods: Medical records were retrospectively reviewed for all spinal tumors operated at our institute during a period of 6 years. Read More

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Intramedullary tumours and tumour mimics.

Clin Radiol 2020 11 23;75(11):876.e17-876.e32. Epub 2020 Jun 23.

University of Iowa Hospital and Clinics, Department of Radiology, Iowa city, IOWA, USA.

Spinal cord lesions are traditionally classified as either extradural or intradural extramedullary or of intramedullary origin. Intramedullary spinal cord tumours are histopathologically similar to cranial tumours with a diverse range of pathologies. Astrocytomas and ependymomas account for approximately 80% of all intramedullary tumours, with other primary and secondary lesions accounting for the remaining 20%. Read More

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November 2020

Intramedullary Masses of the Spinal Cord: Radiologic-Pathologic Correlation.

Radiographics 2020 Jul-Aug;40(4):1125-1145. Epub 2020 Jun 12.

From the Department of Radiology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814 (R.Y.S.); and Department of Radiology, Mayo Clinic, Rochester, Minn (K.K.K.).

Spinal cord tumors are a challenge for patients and neurosurgeons because of the high risk of neurologic deficits from the disease process and surgical interventions. Spinal cord tumors are uncommon, and approximately 2%-3% of primary intra-axial tumors of the central nervous system occur in the spinal cord. Primary intra-axial tumors are usually derived from neuroepithelial tissue, especially glial cells. Read More

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