803 results match your criteria Spinal Imaging in Astrocytoma

Multifocal Desmoplastic Infantile Ganglioglioma/Astrocytoma (DIA/DIG): An Institutional Series Report and a Clinical Summary of This Rare Tumor.

Front Oncol 2021 9;11:608129. Epub 2022 May 9.

School of Computer Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China.

Aim: Multifocal desmoplastic infantile ganglioglioma/astrocytoma (DIA/DIG) has rarely been reported. Here, two cases have been presented, reviewing the literature and proposed treatment algorithms for this rare tumor.

Patients And Methods: We report two patients diagnosed with multifocal DIA/DIGs in West China Hospital. Read More

View Article and Full-Text PDF

Primary intramedullary spinal gliosarcoma: An unusual presentation.

J Cancer Res Ther 2022 Jan-Mar;18(1):270-272

Department of Radiotherapy, Medical College and Hospital, Kolkata, West Bengal, India.

Gliosarcoma is a biphasic central nervous system malignancy composed of glial and mesenchymal components. It is recognized as a rare variant of glioblastoma with unique histology, immunostaining properties, and natural history. Although usually described to primarily involve the brain, a search of the published literature revealed four reported cases of gliosarcoma arising in the spinal cord. Read More

View Article and Full-Text PDF

Biodegradable controlled-release polymer containing butylidenephthalide to treat a recurrent cervical spine glioblastoma with promising result: a compassionate trial report.

Anticancer Drugs 2022 04;33(4):394-399

Department of Neurosurgery, Hualien Tzu Chi Hospital.

Intramedullary spinal glioblastoma multiforme (GBM) tends to recur within 11 months of surgical resection, even after adjuvant chemoradiation therapy. Treatment options for recurrent spinal GBM are often limited. (Z)-n-butylidenephthalide [(Z)-BP] is a natural compound that induces apoptosis, antiproliferation, anti-invasion and antistemness effects in GBM cells. Read More

View Article and Full-Text PDF

Clinical characteristics of glioblastoma with metastatic spinal dissemination.

Ann Palliat Med 2022 Feb;11(2):506-512

Department of Oncology, Beijing Shijitan Hospital of Capital Medical University, Beijing, China.

Background: Metastatic spinal dissemination (MSD) is a rare phenomenon in glioblastoma (GBM). The study aimed to analyze the clinical characteristics of GBM patients with MSD.

Methods: Fifteen GBM patients with MSD, who were treated and followed up with at the Department of Oncology, Beijing Shijitan Hospital, Capital Medical University from September 2012 to February 2021, were selected for this study. Read More

View Article and Full-Text PDF
February 2022

Intraspinal pilocytic astrocytomas: An overview and 2-D illustrative resection technique video.

Surg Neurol Int 2022 11;13:41. Epub 2022 Feb 11.

Department of Neurosurgery, SUNY Upstate Medical University, Syracuse, New York, United States.

Background: Spinal cord pilocytic astrocytomas (PAs) are rare and typically occur in pediatric patients. While PAs are often well-circumscribed and amenable to gross total resection, they sometimes harbor infiltrative components that can invade normal cord parenchyma.

Methods: Here, we present a 59-year-old female with a progressive right-sided hemi-sensory loss, right-sided hemiparesis, and gait imbalance. Read More

View Article and Full-Text PDF
February 2022

Development and Validation of a Personalized Prognostic Prediction Model for Patients With Spinal Cord Astrocytoma.

Front Med (Lausanne) 2021 18;8:802471. Epub 2022 Jan 18.

Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Background: The study aimed to investigate the prognostic factors of spinal cord astrocytoma (SCA) and establish a nomogram prognostic model for the management of patients with SCA.

Methods: Patients diagnosed with SCA between 1975 and 2016 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database and randomly divided into training and testing datasets (7:3). The primary outcomes of this study were overall survival (OS) and cancer-specific survival (CSS). Read More

View Article and Full-Text PDF
January 2022

Management of Glioblastoma Metastatic to the Vertebral Spine.

World Neurosurg 2022 May 26;161:52-53. Epub 2022 Jan 26.

Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address:

Metastatic glioblastoma to the vertebral spine is rarely encountered. The decision to intervene surgically must consider the poor prognosis in these patients. Here we report the case of a 46-year-old woman who presented with sudden weakness of the lower extremities 10 months after diagnosis of a left parietal glioblastoma. Read More

View Article and Full-Text PDF

Intramedullary spinal cord and intraventricular astrocytoma of varied pathology and molecular features in a teenager.

BMJ Case Rep 2022 Jan 17;15(1). Epub 2022 Jan 17.

Neurosciences and Pediatrics, University of California San Diego, La Jolla, California, USA

View Article and Full-Text PDF
January 2022

Magnetic Resonance Imaging in the Contemporary Management of Medulloblastoma: Current and Emerging Applications.

Methods Mol Biol 2022 ;2423:187-214

Department of Radiation Oncology, Neuro-Oncology Disease Management Group, Tata Memorial Centre, Homi Bhabha National Institute (HBNI), Mumbai, India.

Medulloblastoma, the most common malignant primary brain tumor in children, is now considered to comprise of four distinct molecular subgroups-wingless (WNT), sonic hedgehog (SHH), Group 3, and Group 4 medulloblastoma, each associated with distinct developmental origins, unique transcriptional profiles, diverse phenotypes, and variable clinical behavior. Due to its exquisite anatomic resolution, multiparametric nature, and ability to image the entire craniospinal axis, magnetic resonance imaging (MRI) is the preferred and recommended first-line imaging modality for suspected brain tumors including medulloblastoma. Preoperative MRI can reliably differentiate medulloblastoma from other common childhood posterior fossa masses such as ependymoma, pilocytic astrocytoma, and brainstem glioma. Read More

View Article and Full-Text PDF

Oncogenic NTRK fusion in congenital spinal cord glioblastoma: sequencing directs treatment.

Lancet 2021 12;398(10317):2185

Department of Neurological Surgery, University of California, San Francisco, CA, USA; Division of Neurosurgery, University of California, San Francisco, Benioff Children's Hospital Oakland, CA, USA.

View Article and Full-Text PDF
December 2021

Detection of glioblastoma multiforme using quantitative molecular magnetic resonance imaging based on 5-aminolevulinic acid: in vitro and in vivo studies.

MAGMA 2022 Feb 8;35(1):3-15. Epub 2021 Dec 8.

Biomaterials Group, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran.

Objectives: We demonstrated a novel metabolic method based on sequential administration of 5-aminolevulinic acid (ALA) and iron supplement, and ferric ammonium citrate (FAC), for glioblastoma multiforme (GBM) detection using R' and quantitative susceptibility mapping (QSM).

Materials And Methods: Intra-cellular iron accumulation in glioblastoma cells treated with ALA and/or FAC was measured. Cell phantoms containing glioblastoma cells and Wistar rats bearing C glioblastoma were imaged using a 3 T MRI scanner after sequential administration of ALA and FAC. Read More

View Article and Full-Text PDF
February 2022

Advanced Magnetic Resonance Imaging in Pediatric Glioblastomas.

Front Neurol 2021 10;12:733323. Epub 2021 Nov 10.

Division of Neuroradiology, Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States.

The shortly upcoming 5th edition of the World Health Organization Classification of Tumors of the Central Nervous System is bringing extensive changes in the terminology of diffuse high-grade gliomas (DHGGs). Previously "glioblastoma," as a descriptive entity, could have been applied to classify some tumors from the family of pediatric or adult DHGGs. However, now the term "glioblastoma" has been divested and is no longer applied to tumors in the family of pediatric types of DHGGs. Read More

View Article and Full-Text PDF
November 2021

A novel paper MAP method for rapid high resolution histological analysis.

Sci Rep 2021 12 2;11(1):23340. Epub 2021 Dec 2.

Department of Neurosurgery, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.

Three-dimensional visualization of cellular and subcellular-structures in histological-tissues is essential for understanding the complexities of biological-phenomena, especially with regards structural and spatial relationships and pathologlical-diagnosis. Recent advancements in tissue-clearing technology, such as Magnified Analysis of Proteome (MAP), have significantly improved our ability to study biological-structures in three-dimensional space; however, their wide applicability to a variety of tissues is limited by long incubation-times and a need for advanced imaging-systems that are not readily available in most-laboratories. Here, we present optimized MAP-based method for paper-thin samples, Paper-MAP, which allow for rapid clearing and subsequent imaging of three-dimensional sections derived from various tissues using conventional confocal-microscopy. Read More

View Article and Full-Text PDF
December 2021

Paediatric spinal cord low-grade gliomas-evaluation and management of post-surgical residual disease.

Childs Nerv Syst 2022 03 2;38(3):577-586. Epub 2021 Dec 2.

Department of Paediatric Neurosurgery, Great Ormond Street Hospital for Children NHS Foundation Trust, Great Ormond Street, London, WC1N 3JH, UK.

Purpose: To assess the evaluation and management of post-surgical residual disease for low-grade intramedullary spinal cord tumours (IMSCT) in childhood.

Methods: A single-centre retrospective review of low-grade IMSCTs treated between 2000 and 2019. All surgeries were performed with intent of safe maximal resection guided by intra-operative neurophysiological monitoring (IONM). Read More

View Article and Full-Text PDF

Recurrence of cervical intramedullary gliofibroma.

Spinal Cord Ser Cases 2021 11 5;7(1):97. Epub 2021 Nov 5.

Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, 160-8582, Japan.

Introduction: Gliofibroma is a rare tumor that develops in the brain and spinal cord. Due to the rarity of its nature, its pathophysiology and appropriate treatment remain elusive. We report a case of intramedullary spinal cord gliofibroma that was surgically treated multiple times. Read More

View Article and Full-Text PDF
November 2021

Aggressively recurring cervical intramedullary anaplastic astrocytoma in a pregnant patient.

Surg Neurol Int 2021 13;12:466. Epub 2021 Sep 13.

Departments of Neurological Surgery, University of Texas Southwestern, Dallas, Texas, United States.

Background: Many patients with spinal juvenile pilocytic astrocytoma can experience prolonged remission after resection. However, some reports suggest that pregnancy may be associated with progression.

Case Description: The authors provide an image report highlighting a case of rapid and aggressive transformation of an intramedullary astrocytoma of the cervical spine in a pregnant patient. Read More

View Article and Full-Text PDF
September 2021

H3K27M-mutant glioma in thoracic spinal cord and conus medullaris with pilocytic astrocytoma morphology: case report and review of the literature.

Br J Neurosurg 2021 Oct 7:1-7. Epub 2021 Oct 7.

Department of Neurosurgery, La Paz University Hospital, Madrid, Spain.

Background: The H3K27M-mutant spinal cord gliomas are very aggressive with a dismal prognosis, very few cases have been reported in the thoracic spinal cord and conus medullaris, and it is extremely rare with morphological features of pilocytic astrocytoma.

Case Presentation: A 20-year-old man presented with thoracolumbar pain, progressive paraparesis, and urinary incontinence. Magnetic resonance imaging revealed an intramedullary solid-cystic lesion from D9 to conus medullaris. Read More

View Article and Full-Text PDF
October 2021

Intramedullary Spinal Cord Metastasis Mimicking Astrocytoma: A Rare Case Report.

Brain Sci 2021 Aug 25;11(9). Epub 2021 Aug 25.

Department of Human Neurosciences, Division of Neurosurgery, Policlinico Umberto I University Hospital, Sapienza, University of Rome, 00161 Rome, Italy.

Intramedullary spinal cord metastases (ISCMs) are infrequent lesions. Their incidence is estimated to range from 0.9 to 2. Read More

View Article and Full-Text PDF

Clinicoradiological characteristics of primary spinal cord H3 K27M-mutant diffuse midline glioma.

J Neurosurg Spine 2021 Sep 24:1-12. Epub 2021 Sep 24.

1Department of Neurosurgery, Xuanwu Hospital, China International Neuroscience Institute, Capital Medical University, Beijing; and.

Objective: Primary spinal cord H3 K27M-mutant diffuse midline glioma (DMG) is a rare and devastating pathological entity. However, little attention has been paid to this disease. As a result, its clinicoradiological characteristics have yet to be described. Read More

View Article and Full-Text PDF
September 2021

Leptomeningeal dissemination of anaplastic medullary cone astrocytoma: an unexpected findings in a patient with leptomeningeal enhancement and clinical history of multiple myeloma.

Pathologica 2021 Aug;113(4):294-299

Pathology Units, Department of Molecular and Translational Medicine, University of Brescia, Italy.

We report a challenging autopsy case with an insidious clinical presentation with diffuse lepto- and pachymeningeal enhancement in a context of a complex clinical history. Clinical features, neuroradiological and anamnestic data were consistent with central nervous system (CNS) dissemination of a previously known lambda restricted multiple myeloma. Autoptic findings allowed to discard this hypothesis. Read More

View Article and Full-Text PDF

Pediatric Spinal Cord Diseases.

Pediatr Rev 2021 Sep;42(9):486-499

Department of Neurological Surgery, Nicklaus Children's Hospital, Miami, FL.

Spinal cord diseases in pediatric patients are highly variable in terms of presentation, pathology, and prognosis. Not only do they differ with respect to each other but so too with their adult equivalents. Some of the most common diseases are autoimmune (ie, multiple sclerosis, acute disseminated encephalomyelitis, and acute transverse myelitis), congenital (ie, dysraphism with spina bifida, split cord malformation, and tethered cord syndrome), tumor (ie, juvenile pilocytic astrocytoma, ependymoma, and hem-angioblastoma), and vascular (ie, cavernous malformations, arteriovenous malformations, and dural arteriovenous fistulas) in nature. Read More

View Article and Full-Text PDF
September 2021

Histone-mutant glioma presenting as diffuse leptomeningeal disease.

CNS Oncol 2021 09 1;10(3):CNS75. Epub 2021 Sep 1.

Department of Neurology, West Virginia University, Morgantown, WV 26506, USA.

Glioblastoma multiforme is the most common malignant primary brain tumor in adults. Histone H3 mutations have been identified in pediatric and adult gliomas, with H3K27M mutations typically associated with a posterior fossa midline tumor location and poor prognosis. Leptomeningeal disease is a known complication of histone-mutant glioma, but uncommon at the time of initial diagnosis. Read More

View Article and Full-Text PDF
September 2021

Analyses of DNA Methylation Profiling in the Diagnosis of Intramedullary Astrocytomas.

J Neuropathol Exp Neurol 2021 08;80(7):663-673

From the Department of Pathology, Erasme University Hospital, Université Libre de Bruxelles (ULB), Brussels, Belgium.

Intramedullary astrocytomas (IMAs) consist of a heterogeneous group of rare central nervous system (CNS) tumors associated with variable outcomes. A DNA methylation-based classification approach has recently emerged as a powerful tool to further classify CNS tumors. However, no DNA methylation-related studies specifically addressing to IMAs have been performed yet. Read More

View Article and Full-Text PDF

Diffuse midline gliomas, H3 K27M-mutant are associated with less peritumoral edema and contrast enhancement in comparison to glioblastomas, H3 K27M-wildtype of midline structures.

PLoS One 2021 4;16(8):e0249647. Epub 2021 Aug 4.

Radiology and Neuroradiology, Asklepios Klinik Barmbek, Hamburg, Germany.

Purpose: The entity 'diffuse midline glioma, H3 K27M-mutant (DMG)' was introduced in the revised 4th edition of the 2016 WHO classification of brain tumors. However, there are only a few reports on magnetic resonance imaging (MRI) of these tumors. Thus, we conducted a retrospective survey focused on MRI features of DMG compared to midline glioblastomas H3 K27M-wildtype (mGBM-H3wt). Read More

View Article and Full-Text PDF
November 2021

Clinical outcomes and a therapeutic indication of intramedullary spinal cord astrocytoma.

Spinal Cord 2022 Mar 26;60(3):216-222. Epub 2021 Jul 26.

Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan.

Study Design: Retrospective cohort study.

Objectives: Although intramedullary astrocytoma is associated with a high mortality rate, the optimal treatment has not reached a consensus. This study aimed at evaluating neurologic function and overall survival rate (OSR) in the treatment of this tumor. Read More

View Article and Full-Text PDF

Chemotherapy for adult patients with spinal cord gliomas.

Neurooncol Pract 2021 Aug 8;8(4):475-484. Epub 2021 Mar 8.

Department of Neurology, Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland.

Background: The incidence of spinal cord gliomas, particularly in adults is low, and the role of chemotherapy has remained unclear.

Methods: We performed a multicenter, retrospective study of 21 patients diagnosed with spinal cord glioma who received chemotherapy at any time during the disease course. Benefit from chemotherapy was estimated by magnetic resonance imaging. Read More

View Article and Full-Text PDF

Autonomic dysreflexia associated with cervical spinal cord gliofibroma: case report.

BMC Neurol 2021 Jun 29;21(1):252. Epub 2021 Jun 29.

Departments of Neurosurgery, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Gunma, 371-8511, Maebashi, Japan.

Background: Autonomic dysreflexia (AD) is an abnormal reflex of the autonomic nervous system normally observed in patients with spinal cord injury from the sixth thoracic vertebra and above. AD causes various symptoms including paroxysmal hypertension due to stimulus. Here, we report a case of recurrent AD associated with cervical spinal cord tumor. Read More

View Article and Full-Text PDF

Effect of Paclitaxel/etoposide co-loaded polymeric nanoparticles on tumor size and survival rate in a rat model of glioblastoma.

Int J Pharm 2021 Jul 20;604:120722. Epub 2021 May 20.

Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

The aim of this work is to co-load paclitaxel (PTX) and etoposide (ETP) in methoxy poly(ethylene glycol)-poly(lactic-co-glycolic acid) nanoparticles (mPEG-PLGA NPs) to overcome pharmacokinetics and physiological limitations and enhance therapeutic efficacy for treating intracranial glioblastoma. Both drugs were loaded into mPEG-PLGA NPs by a nano-precipitation method. The resultant NPs demonstrated an enhanced cytotoxic effect indicated by lower IC values and augmented cell apoptosis to U87 and C6 glioma cell lines compared to both free drugs. Read More

View Article and Full-Text PDF

Cerebrospinal Fluid Drop Metastases of Canine Glioma: Magnetic Resonance Imaging Classification.

Front Vet Sci 2021 3;8:650320. Epub 2021 May 3.

Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, United States.

Dissemination of glioma in humans can occur as leptomeningeal nodules, diffuse leptomeningeal lesions, or ependymal lesions. Cerebrospinal fluid (CSF) drop metastasis of glioma is not well-recognized in dogs. Ten dogs with at least two anatomically distinct and histologically confirmed foci of glioma were included in this study. Read More

View Article and Full-Text PDF

Intramedullary spinal cord lesions in children.

J Pak Med Assoc 2021 Feb;71(2(B)):775-777

Section of Neurosurgery, Department of Surgery, Aga Khan University Hospital, Karachi.

Paediatric intramedullary spinal cord lesions are uncommon pathologies, prone to result in dismal prognosis if not managed promptly and aggressively. While children usually present in good functional grades compared to adults, early recognition and treatment is important to improve outcomes. In this review, we present tumour demographics, patient factors, and treatment modalities of intramedullary spinal cord lesions in paediatric patients. Read More

View Article and Full-Text PDF
February 2021