1,470 results match your criteria Spinal Dysraphism Myelomeningocele


Posterior cranial fossa maldevelopment in infants with repaired open myelomeningoceles. Double trouble or a dynamic process of posterior cranial fossa abnormalities?

World Neurosurg 2020 Jun 22. Epub 2020 Jun 22.

Fondazione Policlinico Universitario Agostino Gemelli IRCC, Roma-UOC Radiologia e Neuroradiologia, Polo Diagnostica per immagini, radioterapia, oncologia ed ematologia, Area diagnostica per immagini, Rome, Italy; Istituto di Radiologia, Università Cattolica del Sacro Cuore, Rome, Italy.

Objective: Two degrees of posterior cranial fossa (PCF) maldevelopment can be hypothesized in children with myelomeningocele (MMC). This paper investigate the PCF deformation by quantitative MRI analysis in MMC subjects with and without Chiari 2 malformation (CM2).

Methods: Posterior cranial fossa volume (PCFV), posterior cranial fossa brain volume (PCFBV), lengths of PCF, ventriculomegaly, level and extension of the dysraphism were analyzed in magnetic resonance imaging (MRI) of 51 newborns with MMC surgically repaired at birth (and 41 controls). Read More

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http://dx.doi.org/10.1016/j.wneu.2020.06.106DOI Listing

Neuraxial dysraphism in associated syndrome due to improper mesenchymal transition.

Neurol Genet 2020 Jun 1;6(3):e414. Epub 2020 Apr 1.

National Institutes of Health (J.S.R., A.J.C., H.W., Z.Z.), National Cancer Institute Neuro-Oncology Branch; National Institutes of Health (D.P.A., J.D.H.), National Institute of Neurological Disorders and Stroke, Surgical Neurology Branch; National Institutes of Health (Y.P., A.J., K.P.), Eunice Kennedy Shriver National Institute of Child Health and Human Development, Section on Medical Neuroendocrinology; Georgetown Hospital (M.A.N.), Internal Medicine and Pediatrics, Washington DC; National Institutes of Health (J.P.M., D.R.D.), National Institute of Neurological Disorders and Stroke, Mouse Imaging Facility, Bethesda, MD; George Washington University (J.G.S.), Radiology, Washington DC; National Library of Medicine (J.G.S.), MedPix®; National Institutes of Health (M.M.M.), Center for Cancer Research, National Cancer Institute, Laboratory of Pathology; and National Institutes of Health (R.H.K., B.A.K.), National Heart Lung and Blood Institute, Translational Vascular Medicine Branch, Bethesda, MD.

Objective: To investigate the effect of somatic, postzygotic, gain-of-function mutation of Endothelial Per-Arnt-Sim (PAS) domain protein 1 () encoding hypoxia-inducible factor-2α (HIF-2α) on posterior fossa development and spinal dysraphism in gain-of-function syndrome, which consists of multiple paragangliomas, somatostatinoma, and polycythemia.

Methods: Patients referred to our institution for evaluation of new, recurrent, and/or metastatic paragangliomas/pheochromocytoma were confirmed for gain-of-function syndrome by identification of the gain-of-function mutation in resected tumors and/or circulating leukocytes. The posterior fossa, its contents, and the spine were evaluated retrospectively on available MRI and CT images of the head and neck performed for tumor staging and restaging. Read More

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http://dx.doi.org/10.1212/NXG.0000000000000414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164966PMC

Retethering : A Neurosurgical Viewpoint.

J Korean Neurosurg Soc 2020 May 27;63(3):346-357. Epub 2020 Apr 27.

Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul, Korea.

During the follow-up period after surgery for spinal dysraphism, a certain portion of patients show neurological deterioration and its secondary phenomena, such as motor, sensory or sphincter changes, foot and spinal deformities, pain, and spasticity. These clinical manifestations are caused by tethering effects on the neural structures at the site of previous operation. The widespread recognition of retethering drew the attention of medical professionals of various specialties because of its incidence, which is not low when surveillance is adequate, and its progressive nature. Read More

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http://dx.doi.org/10.3340/jkns.2020.0039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218204PMC

Enlargement of Extraspinal Cysts in Spinal Dysraphism : A Reason for Early Untethering.

J Korean Neurosurg Soc 2020 May 27;63(3):342-345. Epub 2020 Apr 27.

Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul, Korea.

Some types of spinal dysraphism can be accompanied by extraspinal cysts, including myelomeningocele, myelocystocele, myelocele, meningocele, limited dorsal myeloschisis, lipomyelomeningocele, and terminal myelocystocele. Each disease is classified according to the developmental mechanism, embryologic process, site of occurrence, or internal structure of the extraspinal cyst. In most cystic spinal dysraphisms except meningocele, part of the spinal cord is attached to the cyst dome. Read More

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http://dx.doi.org/10.3340/jkns.2020.0094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218201PMC

Symptomatic Recurrence of Cervical Spine Myelomeningocele in an Adult Patient.

World Neurosurg 2020 May 26;137:376-378. Epub 2020 Feb 26.

University of South Florida Morsani College of Medicine, Department of Neurosurgery, Tampa General Hospital, Tampa, Florida, USA. Electronic address:

Background: Cervical myelomeningocele (MMC) is a very rare neural type defect that is usually discovered and managed in childhood. It is best described as a closed type of spinal dysraphism, where the posterior portion of the cervical thecal sac forms a pouch that bulges out through a narrow posterior spina bifida and contains spinal neural tissue with or without cerebrospinal fluid.

Case Description: We report a 47-year-old male patient who presented with neck pain and decreased ability to use his fingers that had progressed over 3 years before presentation. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.02.102DOI Listing

The basics of transition in congenital lifelong urology.

World J Urol 2020 Feb 19. Epub 2020 Feb 19.

Department of Pediatric Urology, Riley Children Hospital at Indiana University Health (IHU), Indiana University School of Medicine, 705 Riley Hospital Drive, ROC Suite #4230, Indianapolis, IN, 46202, USA.

Purpose: Transition in urology is defined by the process that allows an adolescent or a young adult with a congenital or acquired urogenital anomaly to assume increasing responsibility for their own health care and to become the primary decision maker in their care.

Methods: A review of the literature regarding transitional care for lifelong urologic congenital anomalies was performed with the aim of reporting expert opinion when data are non-existent. This review focuses on special considerations for adolescents and young adults with spina bifida, bladder exstrophy, anorectal malformations and differences of sexual development. Read More

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http://dx.doi.org/10.1007/s00345-020-03116-zDOI Listing
February 2020

Spontaneous closure of myelomeningocele.

Childs Nerv Syst 2020 Apr 5;36(4):869-871. Epub 2020 Feb 5.

Division of Neurosurgery, Saint Louis University School of Medicine, 1438 S Grand Blvd, St. Louis, MO, 63104, USA.

Fetal repair of myelomeningocele has been increasingly offered to mothers of children with myelomeningocele after the seminal Management of Myelomeningocele (MOMs) trial, which demonstrated decreased reliance on ventriculoperitoneal shunt following fetal closure. We present the case of a fetus diagnosed with a lumbar myelomeningocele in utero whose mother refused in utero closure and who was subsequently born with a skin-covered defect. A fetal MRI was obtained on a mother with a male fetus diagnosed with open neural tube defect at 20 weeks of gestation. Read More

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http://dx.doi.org/10.1007/s00381-019-04454-zDOI Listing

Additional Surgeries after Bladder Augmentation in Patients with Spina Bifida in the 21st Century.

J Urol 2020 Jun 17;203(6):1207-1213. Epub 2020 Jan 17.

Division of Pediatric Urology, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana.

Purpose: We determined the long-term risks of additional surgery after bladder augmentation in a modern spina bifida cohort accounting for differential followup.

Materials And Methods: We retrospectively reviewed patients with spina bifida who were born after 1972 and were followed at our institution after augmentation surgery performed between 1979 and 2018. Outcomes included diversion, bladder stones, perforation, reaugmentation, laparotomy for bowel obstruction, and benign and malignant bladder tumors. Read More

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http://dx.doi.org/10.1097/JU.0000000000000751DOI Listing

Evaluation and Long-term Management of Neurogenic Bladder in Spinal Dysraphism.

Neoreviews 2019 12;20(12):e711-e724

Division of Pediatric Urology, Rady Children's Hospital San Diego, University of California San Diego, San Diego, CA.

Spinal dysraphism, which includes conditions such as myelomeningocele and sacral agenesis, is one of the most common causes of congenital lower urinary tract dysfunction. Early evaluation of the neurogenic bladder serves to minimize renal damage, and the main goals of management include preserving renal function, achieving acceptable continence, and optimizing quality of life. The survival of patients with such conditions has improved to greater than 80% reaching adulthood, owing to advances in diagnostic and therapeutic modalities. Read More

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http://dx.doi.org/10.1542/neo.20-12-e711DOI Listing
December 2019

Pediatric Neuromuscular Disorders.

Pediatr Clin North Am 2020 02;67(1):45-57

Seaview Orthopaedic & Medical Associates, 1200 Eagle Avenue, Ocean, NJ 07712, USA. Electronic address:

Neuromuscular disorders are pathologies that can severely affect the quality of life as well as longevity of patients. The most common disorders include cerebral palsy and myelodysplasia. The orthopedic manifestations of these disorders can be treated operatively or nonoperatively. Read More

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http://dx.doi.org/10.1016/j.pcl.2019.09.002DOI Listing
February 2020

Giant Symptomatic Meningocele as a Delayed, Adult Complication of Lipomyelomeningocele.

World Neurosurg 2020 Feb 21;134:532-535. Epub 2019 Nov 21.

Department of Neurosurgery, Baylor College of Medicine, Houston, Texas, USA.

Background: An expanding cohort of patients with spina bifida live well into adulthood and pose complex management challenges due to unique combinations of adult health issues overlying congenital problems.

Case Description: We present a case of a 45-year-old woman with an expanding, disfiguring, painful lumbar meningocele more than 40 years after her only surgery as a 3-year-old child. A team of pediatric and adult neurosurgeons as well as plastic/reconstructive surgeons successfully performed surgery to obliterate the meningocele, with preservation of her baseline functional status, and no evidence of recurrence after more than 1 year of follow-up. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.11.086DOI Listing
February 2020

Early Vs. Expectant Management of Spina Bifida Patients-Are We All Talking About a Risk Stratified Approach?

Curr Urol Rep 2019 Nov 16;20(11):76. Epub 2019 Nov 16.

Department of Urology, Division of Pediatric Urology, Children's Health System Texas, University of Texas Southwestern, Dallas, TX, USA.

Purpose Of Review: Advancements in the care of patients affected by myelomeningocele have flourished in recent years especially with respect to renal preservation and continence. Involvement of urologists both prenatally and early in life has driven many developments in preventative care and early intervention. As of yet, however, the ideal management algorithm that offers these patients the least invasive diagnostic testing and interventions while still preserving renal and bladder function remains ill defined. Read More

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http://dx.doi.org/10.1007/s11934-019-0943-zDOI Listing
November 2019

Cryopreserved human umbilical cord versus acellular dermal matrix patches for in utero fetal spina bifida repair in a pregnant rat model.

J Neurosurg Spine 2019 Nov;32(2):321-331

1Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Medicine, UTHealth The University of Texas McGovern Medical School and the Fetal Center at Children's Memorial Hermann Hospital, Houston.

Objective: Despite significant improvement in spinal cord function after in utero spina bifida (SB) repair compared with traditional postnatal repair, over half of the children who undergo this procedure do not benefit completely. This lack of benefit has been attributed to closure methods of the defect, with subsequent spinal cord tethering at the repair site. Hence, a regenerative patch or material with antiinflammatory and anti-scarring properties may alleviate comorbidities with improved outcomes. Read More

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http://dx.doi.org/10.3171/2019.7.SPINE19468DOI Listing
November 2019
1 Read

Myelomeningocele sac associated with worse lower-extremity neurological sequelae: evidence for prenatal neural stretch injury?

Ultrasound Obstet Gynecol 2020 Jun;55(6):740-746

Perelman School of Medicine, University of Pennsylvania, PA, USA.

Objective: To determine whether the presence of a myelomeningocele (MMC) sac and sac size correlate with compromised lower-extremity function in fetuses with open spinal dysraphism.

Methods: A radiology database search was performed to identify cases of MMC and myeloschisis (MS) diagnosed prenatally in a single center from 2013 to 2017. All cases were evaluated between 18 and 25 weeks. Read More

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http://dx.doi.org/10.1002/uog.21891DOI Listing
June 2020
1 Read

Concepts in the neurosurgical care of patients with spinal neural tube defects: An embryologic approach.

Birth Defects Res 2019 11 2;111(19):1564-1576. Epub 2019 Oct 2.

University of Wisconsin School of Medicine, Madison, Wisconsin.

Background: The neural tube defects (NTDs) are a heterogeneous group of structural birth defects that arise from a complex array of multiple genetic and environmental factors and adversely affect the structure and function of the brain and spinal cord. Spinal NTDs are clinically more common than cranial NTDs. There remains a significant gap in linking the multiple NTD phenotypes to current genomic understanding. Read More

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http://dx.doi.org/10.1002/bdr2.1588DOI Listing
November 2019
7 Reads

Reviewing the prognostic factors in myelomeningocele.

Neurosurg Focus 2019 10;47(4):E2

6Clinical Research Unit, Fernandes Figueira National Institutes of Health for Women, Children, and Adolescents, Oswaldo Cruz Foundation (IFF-Fiocruz), Rio de Janeiro, Brazil.

Objective: The goal of this study was to analyze the factors that have an impact on morbidity and mortality in patients with myelomeningocele (MMC).

Methods: A retrospective cohort study was conducted to analyze factors associated with MMC that influence the morbidity and mortality of the disease. Data were collected from medical records of children who underwent the primary repair of MMC at the Fernandes Figueira Institute-Oswaldo Cruz Foundation (IFF-Fiocruz) between January 1995 and January 2015, with a minimum follow-up of 1 year. Read More

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http://dx.doi.org/10.3171/2019.7.FOCUS19462DOI Listing
October 2019
2 Reads

Differentiating Asymptomatic Bacteriuria From Urinary Tract Infection in the Pediatric Neurogenic Bladder Population: NGAL As a Promising Biomarker.

Top Spinal Cord Inj Rehabil 2019 ;25(3):214-221

Division of Urology, Nationwide Children's Hospital, Columbus, Ohio.

To evaluate whether urinary antimicrobial peptides (AMPs) can discriminate between asymptomatic bacteriuria (ASB) and urinary tract infection (UTI) in pediatric patients with neurogenic bladder (NGB). Bladder urine was collected from pediatric patients (≤18 years old) with NGB without augmentation cystoplasty. Patients were divided into the following groups based on symptomatology and results of urinalysis/urine culture: (a) UTI, (b) ASB, and (c) sterile. Read More

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http://dx.doi.org/10.1310/sci2503-214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743751PMC
January 2020
2 Reads

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on the Incidence of Tethered Cord Syndrome in Infants With Myelomeningocele With Prenatal Versus Postnatal Repair.

Neurosurgery 2019 09;85(3):E417-E419

Division of Pediatric Neurosurgery, British Columbia Children's Hospital, University of British Columbia, Vancouver, Canada.

Background: The incidence of spina bifida (SB) is higher in the developing world as compared to the United States because of folic acid deficiency during pregnancy. Advances in technology have made prenatal repair of myelomeningocele (MM) possible.

Objective: The objective of this guideline was to determine if there is a difference in the rate of development of tethered cord syndrome (TCS) in infants who had prenatal closure compared to infants who had MM repair after birth. Read More

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http://dx.doi.org/10.1093/neuros/nyz266DOI Listing
September 2019
4 Reads

[Prenatal myelomeningocele repair - a chance to improve the quality of life].

Wiad Lek 2019 ;72(7):1380-1386

Klinika Chirurgii i Urologii Dziecięcej, Wydział Lekarski w Katowicach, Śląski Uniwersytet Medyczny w Katowicach, Katowice, Polska.

Spina bifida (myelomeningocele) is the most prevalent developmental defect of the nervous system. In different regions of the world it affects from 0.3 to 5 per 1000 of living neonates. Read More

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August 2019
4 Reads

Ethical and Legal Dilemmas Around Termination of Pregnancy for Severe Fetal Hydrocephalus, Spina Bifida Aperta and Meningomyelocoella.

Med Arch 2019 Apr;73(2):126-130

Department of Obstetrics and Gynecology, Clinical Hospital "Sveti Duh", Zagreb and Croatian Catholic University Zagreb, Croatia.

Introduction: There are many ethical and moral dilemmas regarding the termination of pregnancy(TOP) with severe fetal anomalies.

Aim: Our aim is to present a case of severe fetal hydrocephalus (HCP), spina bifida aperta and, meningomyelocoella (MMC).

Case Report: A gynecologist examined a 23-year-old patient with vital pregnancy of 24/25 week of gestation (WG) with the anomaly of the fetus. Read More

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https://www.ejmanager.com/fulltextpdf.php?mno=302644210
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http://dx.doi.org/10.5455/medarh.2019.73.126-130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643355PMC
April 2019
2 Reads

Fetal surgery for spina bifida.

J Neurosurg Pediatr 2019 08;24(2):105-114

The two-hit hypothesis of neural injury in the wake of open neural tube defects suggests an opportunity for preservation of function and potential reversibility of early morphological changes in the fetus diagnosed with myelomeningocele. The Management of Myelomeningocele Study (MOMS) demonstrated reduced need for shunting and improved neurological function in patients treated in utero relative to postnatally, thereby offering level 1 evidence supporting fetal repair. Subsequent studies have offered additional information about urological, orthopedic, radiological, and maternal factors surrounding fetal repair. Read More

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http://dx.doi.org/10.3171/2019.4.PEDS18383DOI Listing
August 2019
4 Reads

Endoscopic fetal surgery for neural tube defects.

Best Pract Res Clin Obstet Gynaecol 2019 Jul 29;58:133-141. Epub 2019 Jun 29.

Hospital Israelita Albert Einstein, Fetal Therapy Program, Rua Carlos Millan, 64 ap 181, São Paulo, SP, 01456-030, Brazil. Electronic address:

Prenatal repair of open spina bifida reduces shunt rates and may improve postnatal motor and neurodevelopmental outcomes. The hysterotomy required for the open fetal surgery leaves subsequent pregnancies at risk of uterine rupture. Hysterotomy site rupture confers significant morbidity and mortality risks for both mother and fetus. Read More

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http://dx.doi.org/10.1016/j.bpobgyn.2019.05.001DOI Listing
July 2019
3 Reads

Intracranial infection in patients with myelomeningocele: profile and risk factors.

Childs Nerv Syst 2019 11 9;35(11):2205-2210. Epub 2019 Jul 9.

Division of Neurological Surgery, Department of Surgery, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Purpose: To describe the profile and determine the risk factors for the development of intracranial infections (ICI) in paediatric patients with myelomeningocele (MMC).

Methods: Retrospective analysis of data from the records of patients with MMC admitted into our hospital between January 2006 and December 2015.

Results: We managed a total of 688 paediatric non-trauma neurosurgical patients in our facility during the study period. Read More

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http://dx.doi.org/10.1007/s00381-019-04219-8DOI Listing
November 2019
5 Reads

Awareness of spina bifida among family of affected child. A cross sectional questionnaire.

Saudi Med J 2019 Jul;40(7):727-731

College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, Kingdom of Saudi Arabia. E-mail.

Objectives: To evaluate the awareness of spina bifida (SB), risk factors and possible preventive measures among mothers who had been following in our clinic with a spina bifida affected child. Methods: A cross-sectional questionnaire-based study with 38 mothers of SB patients who are following at SB and hydrocephalus clinic at King Fahad University Hospital, Khobar, Eastern Province, Saudi Arabia.

Results: Thirty-eight mother were included in this questionnaire. Read More

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http://dx.doi.org/10.15537/smj.2019.7.24264DOI Listing
July 2019
3 Reads

Estimated kidney function in children and young adults with spina bifida: A retrospective cohort study.

Neurourol Urodyn 2019 09 8;38(7):1907-1914. Epub 2019 Jul 8.

Division of Nephrology and Hypertension, Feinberg School of Medicine at Northwestern University, Chicago, Illinois.

Aims: Current estimated glomerular filtration rate (eGFR) equations may be inaccurate in patients with spina bifida (SB) because of reduced muscle mass and stature. Cross-sectional and longitudinal variability of eGFR were analyzed in these patients across multiple equations, hypothesizing greater variability in creatinine-based than cystatin-C (Cys-C)-based equations.

Methods: This retrospective cohort study included children (age, 1-17. Read More

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http://dx.doi.org/10.1002/nau.24092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706288PMC
September 2019
2 Reads

Towards Guideline-Based Management of Tethered Cord Syndrome in Spina Bifida: A Global Health Paradigm Shift in the Era of Prenatal Surgery.

Neurospine 2019 Dec 8;16(4):715-727. Epub 2019 Jul 8.

Developmental Pediatrics, Department of Pediatrics, Texas Children's Hospital/Baylor College of Medicine, Houston, TX, USA.

An estimated 60% of the world's population lives in Asia, where the incidence of neural tube defects is high. Aware that tethered cord syndrome (TCS) is an important comorbidity, the purpose of this systematic review was to explore the treatment of TCS among individuals living with spina bifida (SB) in Asia. MEDLINE and Embase databases were searched for relevant studies published from January 2000 to June 2018. Read More

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http://dx.doi.org/10.14245/ns.1836342.171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944994PMC
December 2019
6 Reads

Are primary and secondary types of brain anomalies exclusive factors affecting the attention networks in individuals with spina bifida?

Neuropsychology 2019 Nov 8;33(8):1057-1064. Epub 2019 Jul 8.

Texas Institute for Measurement, Evaluation, and Statistics.

Objective: Individuals with spina bifida myelomeningocele (SBM) frequently exhibit cognitive impairments on tasks mediated by brain regions involved in the posterior attention network. Although such deficits have been historically assumed to result from primary and secondary brain insults, there is a dearth of literature regarding whether sequential versus simultaneous surgical closure of neural folds and surgical shunt placement affect neuropsychological function and brain structure of attention networks that have been widely studied in individuals with SBM. The current study addressed these gaps in a large cohort of children and adults with SBM. Read More

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http://dx.doi.org/10.1037/neu0000581DOI Listing
November 2019
4 Reads

Bladder Self-management in the Transition to Adulthood With Spina Bifida in 3 Countries: A Comparative Study.

J Wound Ostomy Continence Nurs 2019 Jul/Aug;46(4):321-326

Fabiana Faleiros, PhD, Department of General and Specialized Nursing, University of São Paulo at Ribeirão Preto College of Nursing, Ribeirão Preto, Brazil. Seth Warschausky, PhD, Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor. Christoph Käppler, PhD, Department of Social and Emotional Development in Rehabilitation and Pedagogy, University of Dortmund, Germany. William Schutt, PhD, Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor. Michel M. Cintra, MSc, University of São Paulo at Ribeirão Preto College of Nursing, Ribeirão Preto, Brazil. Soraia A. N. Rabeh, PhD, Department of General and Specialized Nursing, University of São Paulo at Ribeirão Preto College of Nursing, Ribeirão Preto, Brazil. Fernanda R. E. Gimenes, PhD, Department of General and Specialized Nursing, University of São Paulo at Ribeirão Preto College of Nursing, Ribeirão Preto, Brazil.

Purpose: The purpose of this study was to evaluate bladder self-management in transition to adult care for patients with spina bifida (SB) in 3 countries with similar clinical practice and different social, cultural, and economic milieu.

Study Design: Cross-sectional study.

Subjects And Setting: The sample comprised 90 participants: 27 reside in Brazil, 36 reside in Germany, and 27 reside in the United States. Read More

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http://dx.doi.org/10.1097/WON.0000000000000545DOI Listing
January 2020
2 Reads

Cervical Lipomyelocele with Congenital Inclusion Cyst.

World Neurosurg 2019 Oct 28;130:122-128. Epub 2019 Jun 28.

Department of Radiodiagnosis, VMMC and Safdarjung Hospital, New Delhi, India.

Background: Spinal dysraphism refers to a group of congenital malformations affecting the spine and the spinal cord. Although there are several varieties, all have one thing in common, i.e. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193183
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http://dx.doi.org/10.1016/j.wneu.2019.06.179DOI Listing
October 2019
9 Reads

Scientific methodology of the development of the Guidelines for the Care of People with Spina Bifida: An initiative of the Spina Bifida Association.

Disabil Health J 2020 Apr 18;13(2):100816. Epub 2019 Jun 18.

Spina Bifida Association, Arlington, VA, USA; Division of Developmental Medicine, Department of Pediatrics, Seattle Children's Hospital and University of Washington School of Medicine, Seattle, WA, USA.

Background: We combined literature review and consensus-building methodologies to develop health care guidelines for people with Spina Bifida across the life span.

Objective: The present paper describes the methodology used to update and expand this fourth edition of the Guidelines for the Care of People with Spina Bifida ("Guidelines"). This process was a fundamental initiative within the Spina Bifida Collaborative Care Network. Read More

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http://dx.doi.org/10.1016/j.dhjo.2019.06.005DOI Listing
April 2020
6 Reads

Ilizarov reconstruction of chronic bilateral calcaneovalgus deformities.

Chin J Traumatol 2019 Aug 20;22(4):202-206. Epub 2019 Apr 20.

Limb Reconstruction Unit, Khoo Teck Puat Hospital, Singapore.

Calcaneovalgus foot deformities are present in up to 35% of patients with lumbar spina bifida. Resultant heel weight bearing causes complications include those associated with pressure ulcers. Early surgical reconstruction is advocated to prevent deformity progression and rigidity. Read More

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http://dx.doi.org/10.1016/j.cjtee.2019.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667992PMC
August 2019
8 Reads

Neurogenic Bladder Dysfunction as Signal of Late Failure of Endoscopic Third Ventriculostomy in Child with Spina Bifida.

World Neurosurg 2019 Aug 24;128:454-457. Epub 2019 May 24.

Department of Integrated Medicine, Federal University of Rio Grande do Norte, Natal, Brazil.

Background: Endoscopic third ventriculostomy (ETV) is an option for hydrocephalus treatment in patients with myelomeningocele, mostly after a previous shunt dysfunction. Late failure of ETV is a rare event, traditionally associated with dramatic symptoms of intracranial hypertension. In patients with myelodysplasia and neurogenic bladder dysfunction, urodynamic deterioration can be a signal of neurologic worsening as a consequence of tethered cord or shunt problems. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.05.138DOI Listing
August 2019
6 Reads

Effect of Prenatal Repair of Myelomeningocele on Urological Outcomes at School Age.

J Urol 2019 10 6;202(4):812-818. Epub 2019 Sep 6.

Center for Fetal Diagnosis and Treatment, the Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Purpose: We investigated longer term urological outcomes in patients enrolled in the Management of Myelomeningocele Study (MOMS).

Materials And Methods: Women who participated in the original trial were asked for consent for followup for their child at age 6 years or older in a single comprehensive study visit to a MOMS center. Participating children underwent urological and radiologic procedures to provide objective evidence of current bladder functioning. Read More

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http://dx.doi.org/10.1097/JU.0000000000000334DOI Listing
October 2019
9 Reads

Program Evaluation of Camp V.I.P: Promoting Self-confidence and Independence for Patients with Spina Bifida.

J Pediatr Nurs 2019 Jul - Aug;47:30-35. Epub 2019 Apr 23.

University of Alabama at Birmingham, Department of Neurosurgery, Section of Pediatric Neurosurgery, United States of America; Children's of Alabama, United States of America. Electronic address:

Purpose: Camp V.I·P (Victory, Independence, Possibilities) was established by the Spina Bifida Association of Alabama in 2012. The goal is to provide children with spina bifida (SB) and their families a traditional-style summer camp focusing on self-empowerment and fostering independence in medical self-management. Read More

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http://dx.doi.org/10.1016/j.pedn.2019.04.014DOI Listing
January 2020
7 Reads

Low level myelomeningoceles: do they need prenatal surgery?

Childs Nerv Syst 2019 06 27;35(6):957-963. Epub 2019 Mar 27.

Department of Pediatric Neurosurgery, Hôpital Femme Mère Enfant, 32 Avenue du Doyen Jean Lépine, 69677, Lyon Cedex, France.

Background: Postnatal closure of a myelomeningocele remains the standard of care in many countries. The prenatal closure has given hope for decreasing the damage to the neural placode and has challenged classic management. However, this technique presents potential sources of complications. Read More

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http://dx.doi.org/10.1007/s00381-019-04123-1DOI Listing
June 2019
21 Reads

Complex spinal dysraphism: myelomenigocele associated with dorsal bony spur, split cord malformation type I, syringomyelia, lipoma and tethered cord.

Br J Neurosurg 2019 Mar 5:1-3. Epub 2019 Mar 5.

a Govind Ballabh Pant Institute of Postgraduate Medical Education and Research (GIPMER) , Neurosurgery , New Delhi , India.

Variations in split cord malformation (SCM) are known. However, association of SCM type I with myelomeningocele along with same level dorsal bony spur has not been described previously. We report a 1-year old male child who presented with these findings with associated syringomyelia, lipoma and tethered cord. Read More

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http://dx.doi.org/10.1080/02688697.2019.1584660DOI Listing
March 2019
22 Reads
0.947 Impact Factor

Impact of neurological level and spinal curvature on pulmonary function in adults with spina bifida.

J Pediatr Rehabil Med 2018 ;11(4):243-254

Human Engineering Research Laboratories, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, USA.

Purpose: To describe pulmonary function and determine the impact of neurological level, scoliosis, and obesity on pulmonary function in people with spina bifida (SB).

Methods: Participants with SB (N= 29) (15 females; age, 30 ± 12 years) completed spirometry and body plethysmographic lung volume testing. Univariate and multivariate regression analyses were used to describe the factors associated with pulmonary function in people with SB. Read More

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http://dx.doi.org/10.3233/PRM-179451DOI Listing
October 2019
22 Reads

Visual Diagnosis: A 19-month-old Girl with a Lumbosacral Mass.

Pediatr Rev 2019 Feb;40(2):e7-e10

Department of Neurosurgery, Children's Mercy Hospitals and Clinics, Kansas City, MO.

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http://pedsinreview.aappublications.org/lookup/doi/10.1542/p
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http://dx.doi.org/10.1542/pir.2017-0078DOI Listing
February 2019
15 Reads

Does fetoscopic or open repair for spina bifida affect fetal and postnatal growth?

Ultrasound Obstet Gynecol 2019 Mar;53(3):314-323

Department of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine, Baylor College of Medicine & Texas Children's Hospital, Houston, TX, USA.

Objective: The effect of fetoscopic myelomeningocele (MMC) repair on fetal growth is unknown. Fetal surgery itself and/or exposure to a carbon dioxide (CO ) environment during spina bifida repair may affect placental function and impair fetal growth. Our aim was to assess and compare growth in fetuses, neonates and infants who underwent prenatal fetoscopic or open MMC repair. Read More

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http://dx.doi.org/10.1002/uog.20220DOI Listing
March 2019
6 Reads

Lumbar Intramedullary Epidermoid Following Repair of Sacral Myelomeningocele and Tethered Cord: A Case Report With a Review of the Relevant Literature and Operative Nuances.

Neurospine 2019 Jun 4;16(2):373-377. Epub 2018 Sep 4.

Department of Neurosurgery, Kovai Medical Center and Hospital, Coimbatore, India.

Epidermoid cysts of the spine are rare tumors. While the majority of them occur spontaneously, in very few cases, they can occur following previous surgery for spinal dysraphism. Such tumors tend to occur at the site of previous surgery. Read More

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http://dx.doi.org/10.14245/ns.1836152.076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603839PMC
June 2019
12 Reads

Decreased MEPs during subcutaneous dissection for untethering surgery of a "true" lipomyelomeningocele: aggravated traction of the spinal cord by release of the sac from the original nest.

Childs Nerv Syst 2019 03 8;35(3):529-533. Epub 2019 Jan 8.

Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.

Purpose: It is well known that the preoperative enlarged sac in occult spinal dysraphism, in which the spinal cord is attached to its dome, can be associated with neurological deficits by aggravation of spinal cord traction. We experienced a similar phenomenon during the early stage of untethering surgery for "lipomyelomeningocele in a strict sense (LMMC)."

Clinical Presentation: We report a case of a 3-month-old girl with LMMC, which showed decreased motor evoked potentials (MEPs) in the lower extremities during the early stage of untethering surgery. Read More

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http://link.springer.com/10.1007/s00381-019-04049-8
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http://dx.doi.org/10.1007/s00381-019-04049-8DOI Listing
March 2019
12 Reads

Early start of clean intermittent catheterization versus expectant management in children with spina bifida.

J Pediatr Surg 2019 Feb 5;54(2):322-325. Epub 2018 Nov 5.

Department of Paediatric Urology, Royal Belfast Hospital for Sick Children, Northern Ireland.

Purpose: We instituted early clean intermittent catheterization (CIC) in 1997 for all newborn infants with spina bifida (SB). We compared this group to a historical group managed expectantly to see if early catheterization was associated with a reduction in renal scar rate as determined by DMSA scanning.

Methods: Data were studied retrospectively on all infants with SB over a recent 13-year period who were treated with early universal CIC in a regional pediatric urology department. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2018.10.096DOI Listing
February 2019
7 Reads
1.311 Impact Factor

Contiguous Diastematomyelia with Lipomyelomeningocele in Each Hemicord-an Exceptional Case of Spinal Dysraphism.

World Neurosurg 2019 Mar 6;123:103-107. Epub 2018 Dec 6.

Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.

Background: Split cord malformation (SCM) is a rare congenital anomaly of the spinal cord. Rarely, SCM coexists with a variety of dysraphic pathologies that occur at the same or different spinal level in a patient. Exceptionally rare is the occurrence of SCM type 1 and lipomeningomyelocele of each hemicord. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183278
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http://dx.doi.org/10.1016/j.wneu.2018.11.225DOI Listing
March 2019
8 Reads
2.417 Impact Factor

Transamniotic stem cell therapy (TRASCET) in a rabbit model of spina bifida.

J Pediatr Surg 2019 Feb 5;54(2):293-296. Epub 2018 Nov 5.

Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA. Electronic address:

Purpose: Transamniotic stem cell therapy (TRASCET) with select mesenchymal stem cells (MSCs) has been shown to induce partial or complete skin coverage of spina bifida in rodents. Clinical translation of this emerging therapy hinges on its efficacy in larger animal models. We sought to study TRASCET in a model requiring intra-amniotic injections 60 times larger than those performed in the rat. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2018.10.086DOI Listing
February 2019
23 Reads

Dynamic magnetic resonance imaging parameters for objective assessment of the magnitude of tethered cord syndrome in patients with spinal dysraphism.

Acta Neurochir (Wien) 2019 01 20;161(1):147-159. Epub 2018 Nov 20.

Department of Radiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Lucknow, 226014, India.

Background: Dynamic magnetic resonance imaging (MRI)-based criteria for diagnosing magnitude of tethered cord syndrome (TCS) in occult spinal dysraphism are proposed.

Methods: In this prospective, case-control design study, MRI lumbosacral spine was performed in 51 subjects [pilot group (n = 10) without TCS (for defining radiological parameters), control group (n = 10) without TCS (for baseline assessment), and study group (n = 31) with spinal dysraphism (thick filum terminale [n = 12], lumbar/lumbosacral meningomyelocoele [n = 6], and lipomyelomeningocoele [n = 13])]. The parameters compared in control and study groups included oscillatory frequency (OF), difference in ratio, in supine/prone position, of distance between posterior margin of vertebral body and anterior margin of spinal cord (oscillatory distance [OD]), with canal diameter, at the level of conus as well as superior border of contiguous two vertebrae above that level; delta bending angle (ΔBA), difference, in supine/prone position, of angle between longitudinal axis of conus and that of lower spinal cord; and sagittal and axial root angles, subtended between exiting ventral nerve roots and longitudinal axis of cord. Read More

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http://dx.doi.org/10.1007/s00701-018-3721-7DOI Listing
January 2019
35 Reads
1.788 Impact Factor

Predictive value of intraoperative bulbocavernosus reflex during untethering surgery for post-operative voiding function.

Clin Neurophysiol 2018 12 30;129(12):2594-2601. Epub 2018 Oct 30.

Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea. Electronic address:

Objective: To evaluate the clinical significance of intraoperative bulbocavernosus reflex (BCR) during untethering surgery in predicting post-operative voiding function.

Methods: We conducted a retrospective review of pediatric patients who underwent untethering surgery with available intraoperative baseline BCR. BCR response during surgery was classified into loss or maintenance. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13882457183126
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http://dx.doi.org/10.1016/j.clinph.2018.09.026DOI Listing
December 2018
32 Reads

The National Spina Bifida Patient Registry: A Decade's journey.

Birth Defects Res 2019 08 6;111(14):947-957. Epub 2018 Nov 6.

Developmental Pediatrics, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.

Background: The National Spina Bifida Patient Registry (NSBPR) was established in 2008, as a partnership between the CDC and spina bifida (SB) clinics throughout the United States. The purpose of this study is to explore the initial work of this project through a literature review of published studies from the NSBPR and provide a description of how this body of literature has developed overtime.

Methods: We included studies indexed in MEDLINE by means of PubMed from January 2009 through April 2018. Read More

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http://dx.doi.org/10.1002/bdr2.1407DOI Listing
August 2019
28 Reads

Bowel management program in patients with spina bifida.

Pediatr Surg Int 2019 Feb 7;35(2):243-245. Epub 2018 Nov 7.

Department of Pediatric Surgery, International Center for Colorectal and Urogenital Care, Children's Hospital Colorado, University of Colorado, Anschutz Medical Campus, 13123 East 16th Avenue, Box 323, Aurora, CO, 80045, USA.

Purpose: Our center has been successfully implementing a bowel management program (BMP) for fecal incontinence consecutive to anorectal malformation and Hirschsprung disease. Recently, the number of patients with spina bifida requiring management for fecal incontinence has increased. The purpose of this study was to review the results of bowel management in patients with spina bifida and the challenges unique to this population. Read More

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http://link.springer.com/10.1007/s00383-018-4403-5
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http://dx.doi.org/10.1007/s00383-018-4403-5DOI Listing
February 2019
51 Reads