1,531 results match your criteria Spinal Dysraphism Myelomeningocele

Contemporary management considerations of urinary tract infections for women with spina bifida.

Int Urogynecol J 2021 Jun 3. Epub 2021 Jun 3.

Houston Methodist Hospital, Department of Urology, Neurourology and Transitional Urology Clinic, Weill Cornell Medical College, Houston, TX, 77030, USA.

Introduction And Hypothesis: Urinary tract infections (UTIs) are one of the leading health concerns and causes of hospitalization for adults with spina bifida (SB). The risk factors, evaluation, management, and prevention of UTIs in women with SB must take into consideration their unique pelvic anatomy and function as well as the desire for pregnancy or the occurrence UTI during pregnancy. This article reviews published literature regarding this topic and offers recommendations for UTI evaluation, management, and prevention in the context of the unique pelvic floor health needs of women with SB. Read More

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Myelomeningocele defect reconstruction with keystone flaps: vascular rationale for the design and operative technique.

Arch Plast Surg 2021 May 15;48(3):254-260. Epub 2021 May 15.

Department of Plastic and Reconstructive Surgery, Hospital Infantil de México (Mexico's Children's Hospital), Mexico City, Mexico.

Background: Myelomeningocele is a frequently seen condition at tertiary care hospitals. Its treatment involves a variety of plastic reconstructive techniques. Herein, we present a series of myelomeningocele patients treated using keystone flaps. Read More

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Open fetal surgery for myelomeningocele repair in France.

J Gynecol Obstet Hum Reprod 2021 Apr 26;50(9):102155. Epub 2021 Apr 26.

Sorbonne University, AP-HP, Trousseau Hospital, DMU ORIGYNE, Department of Fetal Medicine, 26 Avenue du Dr Arnold Netter, 75012 Paris, France; National Reference Center for Rare Disease: Vertebral and Spinal Cord Anomalies (MAVEM Center), AP-HP, Trousseau Hospital, 26 Avenue du Dr Arnold Netter, 75012 Paris, France.

Introduction: Open fetal myelomeningocele (MMC) surgery is currently the standard of care option for prenatal MMC repair. We described the population referred to our center and reviewed outcome after open fetal MMC repair.

Material And Methods: All patients referred to our center for MMC were reviewed from July 2014 to June 2020. Read More

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A Systematic Review of Cognitive Function in Adults with Spina Bifida.

Dev Neurorehabil 2021 Apr 19:1-14. Epub 2021 Apr 19.

Division of Pediatric Neurology, Duke University Health System, Durham, United States.

: Though much research has been done on the cognitive profiles of children, the abilities of patients with SBM as they age into adulthood are not well understood.: Determine if adults with SBM have impairments in overall cognition, attention, executive function, and memory compared to typically developing adults or a standardized population mean.: A medical librarian composed a search of spina bifida, adults, and cognitive function. Read More

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Concurrent Thoracic Spinal Intradural Extramedullary Epidermoid and Neurenteric Cyst in a Spinal Dysraphism Child.

Pediatr Neurosurg 2021 30;56(3):261-267. Epub 2021 Mar 30.

Department of Neurosurgery, AIIMS, New Delhi, India.

Introduction: Intraspinal epidermoid cysts are congenital or acquired in origin; whereas intraspinal neurenteric cysts (NECs) are of congenital origin. Their individual association with spinal dysraphism and vertebral segmentation anomalies is very well known.

Case Presentation: We hereby report a case of concurrent intradural extramedullary epidermoid and NEC at adjacent vertebral levels in a spinal dysraphism child, not reported in English Literature till now. Read More

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Incidence of Urinary Tract Infections in Newborns with Spina Bifida-Is Antibiotic Prophylaxis Necessary?

J Urol 2021 Jul 8;206(1):126-132. Epub 2021 Mar 8.

Division of Urology, Duke University Medical Center, Durham, North Carolina.

Purpose: Urinary tract infections commonly occur in patients with spina bifida and pose a risk of renal scarring. Routine antibiotic prophylaxis has been utilized in newborns with spina bifida to prevent urinary tract infections. We hypothesized that prophylaxis can safely be withheld in newborns with spina bifida until clinical assessment allows for risk stratification. Read More

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Fetal surgery for spina bifida in Zurich: results from 150 cases.

Pediatr Surg Int 2021 Mar 12;37(3):311-316. Epub 2021 Jan 12.

Department of Pediatric Surgery, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland.

Purpose: Over the past 10 years, over 150 fetal spina bifida surgeries were performed at the Zurich Center for Fetal Diagnosis and Therapy. This study looks at surrogates for success and failure of this approach.

Methods: We focused on key outcome parameters including hydrocephalus shunt rate at one year, bladder control at 4, independent ambulation at 3 years, and maternal, fetal, and neonatal complications. Read More

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Guidelines and scientifically-based spina bifida care: Guidance across the lifespan in a global health context.

J Pediatr Rehabil Med 2020 ;13(4):453-455

Division of Developmental Medicine, Department of Pediatrics, Seattle Children's Hospital and the University of Washington School of Medicine, Seattle, WA, USA.

The COVID-19 pandemic has reminded us that, if of nothing else, we live in a globalized community. Enthusiasm for evidenced-based medical knowledge is also contagious. Just as the incidence of SARS-CoV-2, the associated coronavirus, has had a borderless impact on global public health, so too neural tube defects have widespread significance. Read More

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January 2021

Imaging of open spinal dysraphisms in the era of prenatal surgery.

Pediatr Radiol 2020 12 30;50(13):1988-1998. Epub 2020 Nov 30.

Department of Radiology and Medical Imaging, Cincinnati Children's Hospital Medical Center, 333 Burnet Ave., MLC 5031, Cincinnati, OH, 45229-3026, USA.

Over the last decade fetal surgery to repair open spinal dysraphisms has become an acceptable and in some cases desirable alternative to the traditional method of postnatal closure. Fetal MRI is an essential part of the workup in these patients, not only to select the appropriate candidates for fetal surgery but also to guide prenatal counseling and perinatal management. In this article we review current surgical techniques for prenatal repair, relevant imaging findings in the era of fetal surgery, and expected imaging findings of the brain and spine in the fetal and postnatal periods. Read More

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December 2020

Association of spina bifida with cancer.

Transl Androl Urol 2020 Oct;9(5):2358-2369

Division of Urology, Seattle Children's Hospital, Seattle, WA, USA.

While the worldwide incidence of newborns with spinal dysraphism is decreasing, the majority of children now survive and reach adulthood, creating new challenges in patient management and long-term care. Despite medical and surgical advances with a subsequent decline in mortality, spina bifida continues to be a major cause of chronic disability and affected individuals face increased mortality in adulthood. The majority of spina bifida patients have neurogenic bladder. Read More

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October 2020

Diagnostic Test Characteristics of Ultrasound Based Hydronephrosis in Identifying Low Kidney Function in Young Patients with Spina Bifida: A Retrospective Cohort Study.

J Urol 2021 04 18;205(4):1180-1188. Epub 2020 Nov 18.

Nephrology and Hypertension, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Purpose: Kidney dysfunction in spina bifida is usually detected by low estimated glomerular filtration rate or ultrasound based hydronephrosis. We assessed the diagnostic test characteristics of hydronephrosis for detecting low estimated glomerular filtration rate, hypothesizing that hydronephrosis has low sensitivity compared to cystatin C based estimated glomerular filtration rate.

Materials And Methods: We conducted a single center, retrospective cohort study, including patients with spina bifida from 2012-2017 with 2 kidneys and complete data needed to calculate estimated glomerular filtration rate via multiple pediatric (age 1-17. Read More

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Co-existent epidermoid and dermoid in a child with spinal dysraphism.

Childs Nerv Syst 2021 Jun 16;37(6):2087-2090. Epub 2020 Nov 16.

Department of Histopathology, PGIMER, Chandigarh, India.

Both spinal epidermoids and dermoids, given their common embryological origin, are referred as a single entity under the category of spinal inclusion tumors. Many theories, although speculative, have been proposed in relevance to their development. We present a unique case of dual pathology consisting of both epidermoid and dermoid components in a child with spinal dysraphism and succinctly touch upon the related embryological aspects and plausible pathogenesis. Read More

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Pediatric pathology all grown up - An interesting case of adult tethered spinal cord.

Surg Neurol Int 2020 29;11:362. Epub 2020 Oct 29.

Department of Neurosurgery University of Florida, Gainesville, Florida, United States.

Background: Cervical myelopathy in an adult is typically the result of degenerative disease or trauma. Dysraphism is rarely the cause.

Case Description: The authors report the case of a 35-year-old male drywall installer who presented with 2 years of progressive left upper extremity weakness, numbness, and hand clumsiness. Read More

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October 2020

Gait Function in Adults Aged 50 Years and Older With Spina Bifida.

Arch Phys Med Rehabil 2021 04 7;102(4):702-708. Epub 2020 Nov 7.

TRS Resource Center for Rare Disorders, Sunnaas Rehabilitation Hospital, Nesodden, Norway.

Objective: To study gait function among individuals with spina bifida (SB) aged 50 years or older.

Design: A cross-sectional study conducted in 2017.

Setting: Home-dwelling participants from all regions in Norway. Read More

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Lumbar dermoid cysts: 3 illustrative cases and a total review of the literature of the last two decades.

Neurocirugia (Astur : Engl Ed) 2020 Oct 29. Epub 2020 Oct 29.

Unit of Stereotactic and Functional Neurosurgery, General Hospital of Mexico, Dr. Balmis 148, Col. Doctores, Alcaldía Cuauhtémoc, CP 06720 Mexico City, Mexico. Electronic address:

Spinal dermoid cysts are relatively infrequent tumors generally associated with a benign course. Here we describe three cases and analyzed the 109 cases of lumbar dermal cysts described in the literature in the last 20 years. We report a pediatric patient with a dermoid cyst posterior to a lumbar surgery for myelomeningocele repair with bad evolution; and two adult patients with the affection of the motor and autonomic function with good surgical outcomes. Read More

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October 2020

TIMP-2 as a noninvasive urinary marker for predicting neurogenic bladder in patients under follow-up for spina bifida.

Neurourol Urodyn 2021 01 12;40(1):168-175. Epub 2020 Oct 12.

Department of Pediatric Surgery, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Introduction: Neurogenic bladder (NB) post-meningomyelocele (MMC) repair is a major challenge and needs lifelong follow-up. Many cytokines have been implicated in the pathogenesis of NB. To avoid repeated urodynamic studies (UDS) and renal scans, we studied urinary tissue inhibitors of metalloproteinases-2 (TIMP-2) levels and correlated with urodynamic profiles to establish their efficacy. Read More

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January 2021

First trimester cerebral appearance in the presence of closed spina bifida with myelomeningocele, part of the oeis complex.

BMJ Case Rep 2020 Oct 8;13(10). Epub 2020 Oct 8.

Obstetrics and Gynecology, Medgin Prenatal Diagnostic Unit, Craiova, Dolj, Romania.

Our communication presents a prenatally detected case with severe spinal defect detected in the first trimester of pregnancy, accompanied by a large skin-covered myelomeningocele but normal cranio-cerebral structural appearance.These findings suggest that in the first trimester, the extent of the spinal defect, the cerebrospinal fluid leakage to a large, but skin-covered, meningocele and fixation of the spinal cord at the lesion are not sufficient to determine downward hindbrain displacement and the development of secondary signs for open spina bifida.Therefore, we suggest a careful evaluation of the fetal cerebral features if a meningocele is detected. Read More

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October 2020

Diagnostic accuracy of prenatal ultrasound in identifying the level of the lesion in fetuses with open spina bifida: A systematic review and meta-analysis.

Acta Obstet Gynecol Scand 2021 02 11;100(2):210-219. Epub 2020 Oct 11.

Center for Fetal Care and High-risk Pregnancy, Department of Obstetrics and Gynecology, University of Chieti, Chieti, Italy.

Introduction: The role of prenatal ultrasound in correctly identifying the level of the lesion in fetuses with open spina bifida has yet to be determined. The primary aim of this systematic review was to report the diagnostic accuracy of ultrasound in determining the level of the lesion in fetuses with open spina bifida. The secondary aim was to elucidate whether prenatal magnetic resonance imaging (MRI) improves the diagnostic performance of prenatal imaging in correctly identifying the level of the lesion. Read More

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February 2021

Prenatal predictors of motor function in children with open spina bifida: a retrospective cohort study.

BJOG 2021 Jan 4;128(2):384-391. Epub 2020 Nov 4.

Department of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine, Baylor College of Medicine & Texas Children's Hospital, Houston, TX, USA.

Objective: To identify predictors for intact motor function (MF) at birth and at 12 months of life in babies with prenatally versus postnatally repaired open spina bifida (OSB).

Design: Retrospective cohort study.

Setting: Texas Children's Hospital, 2011-2018. Read More

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January 2021

Rapid Magnetic Resonance Imaging of the Spine in Neonates with Spinal Dysraphism.

World Neurosurg 2020 12 19;144:e648-e659. Epub 2020 Sep 19.

Department of Radiology, University of Washington School of Medicine, Seattle Children's Hospital, Seattle, Washington, USA.

Background: The use of nonsedated T2-weighted Half-Fourier Acquisition Single-shot Turbo spin Echo magnetic resonance imaging (MRI) sequences in screening for spinal cord syrinx in neonates with spinal dysraphism has not been reported in the literature. We sought to review our experience using T2-weighted Half-Fourier Acquisition Single-shot Turbo spin Echo imaging of the spine (i.e. Read More

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December 2020

Cranial findings detected by second-trimester ultrasound in fetuses with myelomeningocele: a systematic review.

BJOG 2021 01;128(2):366-374

Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, UK.

Background: Abnormal intracranial findings are often detected at mid-trimester ultrasound (US) in fetuses with myelomeningocele (MMC). It is unclear whether these findings constitute a spectrum of the disease or are an independent finding, which should contraindicate fetal surgery.

Objective: To ascertain the spectrum and frequency of US-detected cranial findings in fetuses with MMC. Read More

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January 2021

Development of a Core outcome set for fetal Myelomeningocele (COSMiC): study protocol.

Trials 2020 Aug 21;21(1):732. Epub 2020 Aug 21.

Department of Obstetrics and Gynaecology, Mount Sinai Hospital and University of Toronto, 600 University Avenue, Toronto, Canada.

Background: Open spina bifida (OSB) is one of the most common congenital central nervous system defects and leads to long-term physical and cognitive disabilities. Open fetal surgery for OSB improves neurological outcomes and reduces the need for ventriculoperitoneal shunting, compared to postnatal surgery, but is associated with a significant risk of prematurity and maternal morbidity. Fetoscopic surgery comes with less maternal morbidity, yet the question remains whether the procedure is neuroprotective and reduces prematurity. Read More

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Psychosocial outcomes for adults with spina bifida: a scoping review protocol.

JBI Evid Synth 2020 05;18(5):1135-1143

Barbara H. Hagan School of Nursing and Health Sciences, Molloy College, Rockville Center, New York, USA.

Objective: The objective of this scoping review is to explore the evidence on psychosocial needs and related outcomes for adults with spina bifida.

Introduction: Individuals with spinal bifida have complex service needs that can lead to the emergence of secondary conditions and health complications, which can result in serious, life-threatening illnesses. While much is known about the biological impact of spina bifida, there is a dearth of information regarding its psychological and social impact. Read More

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Four-hour voiding observation with provocation test reveals significant abnormalities of bladder function in newborns with spinal dysraphism.

J Pediatr Urol 2020 Aug 20;16(4):491.e1-491.e7. Epub 2020 Jun 20.

Department of Biomedical and Clinical Sciences and Department of Pediatrics, Linköping University, SE-581 83, Linköping, Sweden. Electronic address:

Introduction: Four-hour voiding observation with provocation test (VOP) using a scale, a damp detector and ultrasound for determination of residuals, is an easily performed non-invasive method for the evaluation of bladder function in newborns. Neonatal bladder function evaluated with VOP has been described for healthy newborns (HN) but not for children with spinal dysraphism (SD), for whom early bladder evaluation is essential for decisions regarding Clean Intermittent Catheterization and follow-up. The aim of the present study was to describe voiding observation with provocation test in newborns with spinal dysraphism and compare with corresponding data for healthy newborns. Read More

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Trends in Procedures to Initiate Renal Replacement Therapy among People Living with Spina Bifida.

J Urol 2021 Jan 27;205(1):250-256. Epub 2020 Jul 27.

Dow Division of Health Services Research, Department of Urology, University of Michigan, Ann Arbor, Michigan.

Purpose: Given the increasing prevalence of chronic kidney disease in people with spina bifida, we sought to determine if this is associated with an increase in end stage kidney disease. We examined population based data to measure the frequency of procedures to establish renal replacement therapy-a marker for end stage kidney disease-among patients with spina bifida.

Materials And Methods: We used the Healthcare Cost and Utilization Project State Inpatient Database and State Ambulatory Surgery and Services Database from Florida, Kentucky, Maryland and New York (2000 to 2014), which include encounter level data. Read More

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January 2021

Relationship Between Motor Level and Wheelchair Transfer Ability in Spina Bifida: A Study From the National Spina Bifida Patient Registry.

Arch Phys Med Rehabil 2020 11 16;101(11):1953-1960. Epub 2020 Jul 16.

Department of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Veterans Affairs Pittsburgh Healthcare System, Human Engineering Research Laboratories, Pittsburgh, Pennsylvania; Department of Rehabilitation Science and Technology, School of Health and Rehabilitation Sciences, University of Pittsburgh, Pennsylvania. Electronic address:

Objective: To identify the specific features that contribute to the variability in baseline wheelchair transfer and the changes in transfer ability (gain or loss) over time for a large cohort of patients with spina bifida (SB) in the National Spina Bifida Patient Registry.

Design: Longitudinal cohort study.

Setting: A total of 35 United States outpatient SB clinic sites. Read More

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November 2020

"I Tell Them What I Can Feel and How Far My Legs Can Bend": Optimizing Sexual Satisfaction for Women With Spina Bifida.

J Sex Med 2020 09 12;17(9):1694-1704. Epub 2020 Jul 12.

Department of Urology, University of Michigan, Ann Arbor, MI, USA.

Background: There is a high reported rate of sexual dysfunction among women with spina bifida, but little is known about the etiology of this or how sexual satisfaction could be improved.

Aim: To identify, through the words of women with spina bifida, perceived causes of diminished sexual satisfaction and recommendations to optimize partnered sexual encounters.

Methods: In this qualitative study, we conducted semi-structured individual interviews with 22 women with spina bifida (median age 26. Read More

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September 2020

Understanding the Mothers of Children with Spina Bifida and Hydrocephalus in Tanzania.

World Neurosurg 2020 10 8;142:e331-e336. Epub 2020 Jul 8.

Muhimbili Orthopaedic Institute, Dar Es Salaam, Tanzania.

Objective: To identify if there are cultural, medical, educational, economic, nutritional and geographic barriers to the prevention and treatment of spina bifida and hydrocephalus.

Methods: The mothers of infants with spina bifida and hydrocephalus admitted to Muhimbilli Orthopaedic Institute, Dar Es Salaam, Tanzania, between 2013 and 2014 were asked to complete a questionnaire. A total of 299 infants were identified: 65 with myelomeningoceles, 19 with encephaloceles, and 215 with isolated hydrocephalus. Read More

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October 2020