1,416 results match your criteria Spinal Dysraphism Myelomeningocele


Low level myelomeningoceles: do they need prenatal surgery?

Childs Nerv Syst 2019 Mar 27. Epub 2019 Mar 27.

Department of Pediatric Neurosurgery, Hôpital Femme Mère Enfant, 32 Avenue du Doyen Jean Lépine, 69677, Lyon Cedex, France.

Background: Postnatal closure of a myelomeningocele remains the standard of care in many countries. The prenatal closure has given hope for decreasing the damage to the neural placode and has challenged classic management. However, this technique presents potential sources of complications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00381-019-04123-1DOI Listing
March 2019
1 Read

Complex spinal dysraphism: myelomenigocele associated with dorsal bony spur, split cord malformation type I, syringomyelia, lipoma and tethered cord.

Br J Neurosurg 2019 Mar 5:1-3. Epub 2019 Mar 5.

a Govind Ballabh Pant Institute of Postgraduate Medical Education and Research (GIPMER) , Neurosurgery , New Delhi , India.

Variations in split cord malformation (SCM) are known. However, association of SCM type I with myelomeningocele along with same level dorsal bony spur has not been described previously. We report a 1-year old male child who presented with these findings with associated syringomyelia, lipoma and tethered cord. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/02688697.2019.1584660DOI Listing
March 2019
7 Reads
0.947 Impact Factor

Visual Diagnosis: A 19-month-old Girl with a Lumbosacral Mass.

Pediatr Rev 2019 Feb;40(2):e7-e10

Department of Neurosurgery, Children's Mercy Hospitals and Clinics, Kansas City, MO.

View Article

Download full-text PDF

Source
http://pedsinreview.aappublications.org/lookup/doi/10.1542/p
Publisher Site
http://dx.doi.org/10.1542/pir.2017-0078DOI Listing
February 2019
7 Reads

Lumbar Intramedullary Epidermoid Following Repair of Sacral Myelomeningocele and Tethered Cord: A Case Report With a Review of the Relevant Literature and Operative Nuances.

Neurospine 2018 Sep 4. Epub 2018 Sep 4.

Department of Neurosurgery, Kovai Medical Center and Hospital, Coimbatore, India.

Epidermoid cysts of the spine are rare tumors. While majority of them occur spontaneously, very few occur following a previous surgery for spinal dysraphism. Such tumors tend to occur at the site of previous surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14245/ns.1836152.076DOI Listing
September 2018
4 Reads

Early start of clean intermittent catheterization versus expectant management in children with spina bifida.

J Pediatr Surg 2019 Feb 5;54(2):322-325. Epub 2018 Nov 5.

Department of Paediatric Urology, Royal Belfast Hospital for Sick Children, Northern Ireland.

Purpose: We instituted early clean intermittent catheterization (CIC) in 1997 for all newborn infants with spina bifida (SB). We compared this group to a historical group managed expectantly to see if early catheterization was associated with a reduction in renal scar rate as determined by DMSA scanning.

Methods: Data were studied retrospectively on all infants with SB over a recent 13-year period who were treated with early universal CIC in a regional pediatric urology department. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpedsurg.2018.10.096DOI Listing
February 2019
3 Reads

Contiguous Diastematomyelia with Lipomyelomeningocele in Each Hemicord-an Exceptional Case of Spinal Dysraphism.

World Neurosurg 2019 Mar 6;123:103-107. Epub 2018 Dec 6.

Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.

Background: Split cord malformation (SCM) is a rare congenital anomaly of the spinal cord. Rarely, SCM coexists with a variety of dysraphic pathologies that occur at the same or different spinal level in a patient. Exceptionally rare is the occurrence of SCM type 1 and lipomeningomyelocele of each hemicord. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S18788750183278
Publisher Site
http://dx.doi.org/10.1016/j.wneu.2018.11.225DOI Listing
March 2019
3 Reads
2.417 Impact Factor

Transamniotic stem cell therapy (TRASCET) in a rabbit model of spina bifida.

J Pediatr Surg 2019 Feb 5;54(2):293-296. Epub 2018 Nov 5.

Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA. Electronic address:

Purpose: Transamniotic stem cell therapy (TRASCET) with select mesenchymal stem cells (MSCs) has been shown to induce partial or complete skin coverage of spina bifida in rodents. Clinical translation of this emerging therapy hinges on its efficacy in larger animal models. We sought to study TRASCET in a model requiring intra-amniotic injections 60 times larger than those performed in the rat. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpedsurg.2018.10.086DOI Listing
February 2019
3 Reads

Dynamic magnetic resonance imaging parameters for objective assessment of the magnitude of tethered cord syndrome in patients with spinal dysraphism.

Acta Neurochir (Wien) 2019 Jan 20;161(1):147-159. Epub 2018 Nov 20.

Department of Radiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Lucknow, 226014, India.

Background: Dynamic magnetic resonance imaging (MRI)-based criteria for diagnosing magnitude of tethered cord syndrome (TCS) in occult spinal dysraphism are proposed.

Methods: In this prospective, case-control design study, MRI lumbosacral spine was performed in 51 subjects [pilot group (n = 10) without TCS (for defining radiological parameters), control group (n = 10) without TCS (for baseline assessment), and study group (n = 31) with spinal dysraphism (thick filum terminale [n = 12], lumbar/lumbosacral meningomyelocoele [n = 6], and lipomyelomeningocoele [n = 13])]. The parameters compared in control and study groups included oscillatory frequency (OF), difference in ratio, in supine/prone position, of distance between posterior margin of vertebral body and anterior margin of spinal cord (oscillatory distance [OD]), with canal diameter, at the level of conus as well as superior border of contiguous two vertebrae above that level; delta bending angle (ΔBA), difference, in supine/prone position, of angle between longitudinal axis of conus and that of lower spinal cord; and sagittal and axial root angles, subtended between exiting ventral nerve roots and longitudinal axis of cord. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00701-018-3721-7DOI Listing
January 2019
19 Reads
1.788 Impact Factor

Bowel management program in patients with spina bifida.

Pediatr Surg Int 2019 Feb 7;35(2):243-245. Epub 2018 Nov 7.

Department of Pediatric Surgery, International Center for Colorectal and Urogenital Care, Children's Hospital Colorado, University of Colorado, Anschutz Medical Campus, 13123 East 16th Avenue, Box 323, Aurora, CO, 80045, USA.

Purpose: Our center has been successfully implementing a bowel management program (BMP) for fecal incontinence consecutive to anorectal malformation and Hirschsprung disease. Recently, the number of patients with spina bifida requiring management for fecal incontinence has increased. The purpose of this study was to review the results of bowel management in patients with spina bifida and the challenges unique to this population. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00383-018-4403-5
Publisher Site
http://dx.doi.org/10.1007/s00383-018-4403-5DOI Listing
February 2019
24 Reads

Ependyma-Lined Canal with Surrounding Neuroglial Tissues in Lumbosacral Lipomatous Malformations: Relationship with Retained Medullary Cord.

Pediatr Neurosurg 2018 2;53(6):387-394. Epub 2018 Nov 2.

Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: An ependyma-lined canal with surrounding neuroglial tissues can be present in lumbosacral lipomatous malformations; however, the precise embryological significance is still unclear.

Method: Six out of 50 patients with lipomatous malformations had ependymal structures. We retrospectively analyzed the clinical, neuroradiological, and histological findings of these patients to demonstrate the relationship with the embryological background of the retained medullary cord (RMC), which normally regresses, but was retained here because of late arrest of secondary neurulation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000494029DOI Listing
January 2019
9 Reads

Can dynamic ultrasonography replace urodynamics in the follow-up of patients with myelomeningocele? A prospective concurrent study.

Neurourol Urodyn 2019 Jan 23;38(1):278-284. Epub 2018 Oct 23.

Department of Urology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.

Aims: To evaluate the accuracy of dynamic ultrasonography (DUS), as a feasible alternative diagnostic method to identify detrusor overactivity (DO) in patients with neurogenic bladder.

Methods: We performed concurrent analysis of 81 pairs of urodynamic study (UDS) and DUS, in 63 patients with myelomeningocele (MMC), from June 2014 to February 2017. The assessment focused on bladder behavior during the filling phase, DO evaluation, DO with leakage, compliance, and maximum cystometric capacity (MCC). Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/nau.23846
Publisher Site
http://dx.doi.org/10.1002/nau.23846DOI Listing
January 2019
18 Reads

Myelomeningocele Versus Myelocele on Fetal MR Images: Are There Differences in Brain Findings?

AJR Am J Roentgenol 2018 Dec 17;211(6):1376-1380. Epub 2018 Oct 17.

1 Department of Radiology and Medical Imaging, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229-3026.

Objective: The purpose of this study was to examine differences between patients with myelomeningocele and those with myelocele with respect to brain imaging findings at fetal MRI.

Materials And Methods: A single-center retrospective analysis was performed of fetal MRI examinations revealing open spinal dysraphism from 2004 through 2016 with available diagnostic postnatal spinal MR images in conjunction with neurosurgical follow-up findings. Images were reviewed by two board-certified fellowship-trained pediatric neuroradiologists. Read More

View Article

Download full-text PDF

Source
https://www.ajronline.org/doi/10.2214/AJR.18.20088
Publisher Site
http://dx.doi.org/10.2214/AJR.18.20088DOI Listing
December 2018
22 Reads

Impact of gait analysis on pathology identification and surgical recommendations in children with spina bifida.

Gait Posture 2019 01 9;67:128-132. Epub 2018 Oct 9.

Children's Hospital Los Angeles, Los Angeles, CA, USA.

Background: Gait analysis provides quantitative data that can be used to supplement standard clinical evaluation in identifying and understanding gait problems. It has been established that gait analysis changes treatment decision making for children with cerebral palsy, but this has not yet been studied in other diagnoses such as spina bifida.

Research Question: To determine the effects of gait analysis data on pathology identification and surgical recommendations in children with spina bifida. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09666362183086
Publisher Site
http://dx.doi.org/10.1016/j.gaitpost.2018.10.003DOI Listing
January 2019
6 Reads

Hip Status and Long-term Functional Outcomes in Spina Bifida.

J Pediatr Orthop 2019 Mar;39(3):e168-e172

Department of Surgery, Division of Orthopaedic Surgery, Ann and Robert H. Lurie Children's Hospital of Chicago.

Background: Nearly 50% of individuals with myelomeningocele will develop a dislocated hip by skeletal maturity. The purpose of this study was to determine the influence of hip status on functional outcomes in a cohort of adult patients with myelomeningocele.

Methods: Patients with a diagnosis of myelomeningocele >18 years were prospectively enrolled over a 12-month period. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=01241398-900000000-9882
Publisher Site
http://dx.doi.org/10.1097/BPO.0000000000001266DOI Listing
March 2019
6 Reads

Prenatal diagnosis, natural history, postnatal treatment and outcome of 222 cases of spina bifida: experience of a tertiary center.

Ultrasound Obstet Gynecol 2019 Mar 11;53(3):302-308. Epub 2019 Feb 11.

Department of Women and Child Health, Obstetrics and Neonatology Area, Centro Studi per la Tutela della Salute della Madre e del Concepito, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

Objectives: To report on the prenatal ultrasonographic diagnosis of spina bifida (SB) and its natural history, treatment and long-term outcome in a large tertiary referral center.

Methods: All cases of SB diagnosed between February 1980 and December 2015 in the Obstetric Prenatal Diagnosis Day Unit of the Obstetrics and Gynecology Department at the Catholic University of the Sacred Heart, Rome, were reviewed. All infants with an open defect were delivered by elective Cesarean section and underwent early repair of the spinal defect. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/uog.20136DOI Listing
March 2019
7 Reads

Expression profiles of pro-inflammatory and pro-apoptotic mediators in secondary tethered cord syndrome after myelomeningocele repair surgery.

Childs Nerv Syst 2019 Feb 3;35(2):315-328. Epub 2018 Oct 3.

Department of Neurosurgery, University Hospital of Schleswig-Holstein Campus Kiel, Arnold-Heller-Str. 3, House 41, 24105, Kiel, Germany.

Purpose: The literature on histopathological and molecular changes that might underlie secondary tethered cord syndrome (TCS) after myelomeningocele (MMC) repair surgeries remains sparse. To address this problem, we analyzed specimens, which were obtained during untethering surgeries of patients who had a history of MMC repair surgery after birth.

Methods: Specimens of 12 patients were analyzed in this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00381-018-3984-6DOI Listing
February 2019
7 Reads

Spontaneous Pneumocephalus Secondary to Leaking Myelomeningocele.

J Pediatr Neurosci 2018 Jul-Sep;13(3):329-330

Department of Neurosurgery, Government Medical College, Thiruvananthapuram, Kerala, India.

Myelomeningocele is one among the most common forms of spinal dysraphism. We report a newborn male child with leaking myelomeningocele who presented with apneic spells. He underwent a magnetic resonance imaging of the neuraxis, which revealed Chiari malformation and severe hydromyelia along with pneumocephalus. Read More

View Article

Download full-text PDF

Source
http://www.pediatricneurosciences.com/text.asp?2018/13/3/329
Publisher Site
http://dx.doi.org/10.4103/JPN.JPN_17_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144603PMC
October 2018
16 Reads

Intermittent Catheterization and Urinary Tract Infection: A Comparative Study Between Germany and Brazil.

J Wound Ostomy Continence Nurs 2018 Nov/Dec;45(6):521-526

Fabiana Faleiros, PhD, RN, University of São Paulo at Ribeirão Preto College of Nursing, São Paulo, Brazil. Christoph de Oliveira Käppler, PhD, Faculty of Rehabilitation Sciences, University of Dortmund, Germany. Talita Rosa, RN, University of São Paulo at Ribeirão Preto College of Nursing, São Paulo, Brazil. Fernanda Raphael Escobar Gimenes, PhD, RN, University of São Paulo at Ribeirão Preto College of Nursing, São Paulo, Brazil.

Purpose: The purpose of this study was to describe and compare factors that affect urinary tract infection (UTI) rates in people with spina bifida (SB) and neurogenic bladder dysfunction before and following initiation of intermittent catheterization (IC).

Design: A quantitative, descriptive, correlational study.

Subjects And Setting: The study included people who were from Germany, a high-income nation, and Brazil, a middle-income nation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/WON.0000000000000476DOI Listing
March 2019
17 Reads

Improved Bowel Function in Patients with Spina Bifida After Bone Marrow-Derived Mononuclear Cell Transplantation: A Report of 2 Cases.

Am J Case Rep 2018 Aug 25;19:1010-1018. Epub 2018 Aug 25.

Stem Cell and Immune Cell Department, Vinmec Research Institute of Stem Cell and Gene Technology, Times City, Ha Noi, Vietnam.

BACKGROUND Bowel dysfunction is observed in 42.2-71.2% of patients with spina bifida. Read More

View Article

Download full-text PDF

Source
https://www.amjcaserep.com/abstract/index/idArt/909801
Publisher Site
http://dx.doi.org/10.12659/AJCR.909801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120349PMC
August 2018
15 Reads

Caudal cell mass developmental aberrations: an imaging approach.

Clin Imaging 2018 Nov - Dec;52:216-225. Epub 2018 Jul 21.

University of Rochester Medical Center, Rochester, NY, USA.

The objective of this review is to describe antenatal and postnatal imaging criteria, which allow diagnosis and aid workup, prognostication and treatment of developmental anomalies of the caudal cell mass. The lower spinal cord (conus medullaris), filum terminale and inferior lumbar and sacral nerve roots develop from the caudal cell mass, a remnant of the embryologic primitive streak composed of undifferentiated pluripotential cells. Anomalous caudal cell mass development can manifest as tight filum terminale, caudal dysgenesis, terminal myelocystocele, anterior sacral meningocele or sacrococcygeal teratoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clinimag.2018.07.014DOI Listing
January 2019
2 Reads

Cerebral Diffusivity Changes in Fetuses with Chiari II Malformation.

Fetal Diagn Ther 2019 17;45(4):268-274. Epub 2018 Aug 17.

Divisions of Diagnostic Imaging and Radiology, Children's National Health System, and The George Washington University School of Medicine, Washington, District of Columbia, USA.

Objectives: Chiari II malformation is a congenital abnormality characterized by a small posterior fossa with downward displacement of the hindbrain into the foramen magnum. Diffusion-weighted imaging (DWI) can be used to quantitatively characterize brain injury and physiological maturation. We aim to evaluate DWI parameters of the infra- and supratentorial brain in fetuses with Chiari II malformation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000490102DOI Listing
August 2018
24 Reads

Generation of integration-free induced pluripotent stem cells from a patient with spina bifida.

Stem Cell Res 2018 08 17;31:27-30. Epub 2018 May 17.

Department of Pediatrics, Dell Pediatric Research Institute, Dell Medical School, University of Texas at Austin, Austin, TX 78723, United States. Electronic address:

A skin biopsy was obtained from a 14-year-old female patient with a history of Myelomeningocele. Dermal fibroblasts were isolated and reprogrammed with Sendai virus (SeV) vectors encoding OCT3/4, SOX2, KLF4, and c-MYC. The generated induced Pluripotent Stem Cell (iPSC) clones NTDi4_09A were free of genomically integrated reprogramming genes, had a stable normal karyotype and expressed pluripotency markers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scr.2018.05.007DOI Listing
August 2018
7 Reads

Fetal surgery for spina bifida aperta.

Arch Dis Child Fetal Neonatal Ed 2018 Nov 13;103(6):F589-F595. Epub 2018 Jul 13.

Academic Department Development and Regeneration, Cluster Woman and Child, Biomedical Sciences, Faculty of Medicine, Catholic University of Leuven, Leuven, Belgium.

Spina bifida aperta (SBA) is one of the most common congenital malformations. It can cause severe lifelong physical and neurodevelopmental disabilities. Experimental and clinical studies have shown that the neurological deficits associated with SBA are not simply caused by incomplete neurulation at the level of the lesion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/archdischild-2018-315143DOI Listing
November 2018
10 Reads

Using subdural strip electrodes to define functional sensory nerves and the most inferior functional portion of the conus medullaris during detethering surgeries for tethered cord syndrome: a pilot study.

J Neurosurg Spine 2018 Oct 13;29(4):456-460. Epub 2018 Jul 13.

1Department of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital.

Objective: The aim of this study was to investigate the feasibility of using subdural strip electrodes, placed just rostral to the surgical field, to record sensory evoked potentials (SEPs) from the lumbosacral sensory nerves and define the most inferior functional portion of the conus medullaris during detethering surgery for spinal dysraphism and/or tethered cord syndrome (TCS).

Methods: Six patients, 2 boys and 4 girls, aged 0.5 to 16 years, were enrolled in this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3171/2018.2.SPINE171240DOI Listing
October 2018
4 Reads

Prenatal diagnosis of closed spina bifida: multicenter case series and review of the literature.

J Matern Fetal Neonatal Med 2018 Sep 6:1-7. Epub 2018 Sep 6.

a Department of Obstetrics, Paulista School of Medicine , Federal University of São Paulo (EPM-UNIFESP) , São Paulo , Brazil.

Objective: Closed spina bifida (CSB) is an abnormality of the posterior arch formation in which the defect is covered by the skin, without protrusion of nervous tissue. The prenatal diagnosis of CSB is very difficult, rarely diagnosed antenatally.

Methods: We present a multicenter case series of six prenatal diagnosis of CSB using two-dimensional (2D) ultrasonography complemented with three-dimensional (3D) ultrasonography and magnetic resonance imaging (MRI). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14767058.2018.1500543DOI Listing
September 2018
35 Reads

Cystic Cervical Dysraphism: Experience of 12 Cases.

J Pediatr Neurosci 2018 Jan-Mar;13(1):39-45

Department of Neurosurgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Introduction: Cystic spinal dysraphism of the cervical region is a relatively rare entity, which is more frequently associated with congenital anomalies such as split cord malformation, Chiari malformation, and corpus callosum agenesis, when compared to their lumbosacral counterpart. In our study, we have highlighted the clinical spectrum, associated anomalies (both neural and extra-neural), and surgical nuances of these.

Materials And Methods: This study is a retrospective analysis of 225 patients from June 2010 to April 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/JPN.JPN_30_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982491PMC
June 2018
5 Reads

In utero open surgery: progress or stagnation in the prenatal management of spina bifida?

Authors:
Y Ville

BJOG 2018 09 11;125(10):1287. Epub 2018 Jul 11.

Obstetrics and Fetal Medicine Department, Necker-Enfants Malades Hospital, University of Paris Medical School, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1471-0528.15311DOI Listing
September 2018

Homologous cryopreserved amniotic membrane in the repair of myelomeningocele: preliminary experience.

Acta Neurochir (Wien) 2018 Aug 1;160(8):1625-1631. Epub 2018 Jun 1.

Department of Neurosurgery, Treviso Hospital, University of Padova, Via Piazzale 1, 31100, Padova, Treviso, Italy.

Objective: Surgical management of spinal dysraphism often requires the use of dural substitutes. Amniotic membrane (AM) has drawn the interest of clinicians for its valuable concentration of cytokines and factors capable of promoting wound healing, re-epithelialization, inhibiting fibrosis and regulating angiogenesis. These beneficial qualities could make AM an interesting dural substitute for spina bifida repair. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00701-018-3577-xDOI Listing
August 2018
4 Reads
1.790 Impact Factor

The Prevalence of Scoliosis in Spina Bifida Subpopulations: A Systematic Review.

Am J Phys Med Rehabil 2018 Nov;97(11):848-854

From Physical and Rehabilitation Medicine, University Hospitals Leuven, Leuven, Belgium (AH, KP, CK); Clinical and Experimental Sciences Department, University of Brescia, Brescia, Italy (SN); IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy (SN); Department of Development and Regeneration, University Hospitals Leuven, Leuven, Belgium (KJ); and Orthopaedic Surgery, University Hospitals Leuven, Leuven, Belgium (PM, SS).

Prevalence of scoliosis within spina bifida subpopulations is important for diagnostics and therapeutic purposes. This review determined the prevalence of scoliosis within spina bifida subpopulations by means of a systematic literature review by using the following databases: Medline PubMed, Embase, Cochrane, and Pedro. All Dutch- and English-written literature using the MESH terms "spinal dysraphism," "neural tube defects," and "scoliosis" was analyzed using the exclusion criteria: animal studies, case reports, studies regarding the prevalence of spina bifida among patients with scoliosis, studies with inclusion of patients with scoliosis of less than 11 degrees without possibility to identify subgroups with scoliosis of greater than 10 degrees, studies without an own study group, articles comprising the same patient group as another article, neural tube defects besides spina bifida, and articles without specification of spina bifida subtype. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PHM.0000000000000966DOI Listing
November 2018
4 Reads

Adult Versus Pediatric Tethered Cord Syndrome: Clinicoradiological Differences and its Management.

Asian J Neurosurg 2018 Apr-Jun;13(2):264-270

Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Background: Dysraphic lesions in adults, presenting clinically as tethered cord syndrome (TCS), are relatively rare, and their optimal management remains controversial.

Patients And Methods: We performed a retrospective analysis of our pediatric database over a period of last 7 years to focus on the adult TCS. Our aim was to determine the clinicoradiological and etiopathological differences between adult and pediatric patients as well as to determine the results of surgery in adult TCS. Read More

View Article

Download full-text PDF

Source
http://www.asianjns.org/text.asp?2018/13/2/264/228566
Publisher Site
http://dx.doi.org/10.4103/1793-5482.228566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898090PMC
April 2018
35 Reads

Acute Communicating Hydrocephalus as Spinal Cord Surgery Complication in Patient with Lumbar Lipomyelocele.

World Neurosurg 2018 Jul 17;115:468-472.e2. Epub 2018 Apr 17.

Department of Neurosurgery, Istituto Giannina Gaslini, Genoa, Italy.

Background: A lumbar lipomyelocele is a closed spinal dysraphism that can cause tethered cord syndrome. Between 5% and 15% of spinal dysraphism surgery cases are burdened with complications, the most common being wound infections or dehiscence and cerebrospinal fluid leak. Acute communicating hydrocephalus has never been described as a complication of this type of surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wneu.2018.04.052DOI Listing
July 2018
14 Reads

Incontinence affects health-related quality of life in children and adolescents with spina bifida.

J Pediatr Urol 2018 Jun 21;14(3):279.e1-279.e8. Epub 2018 Mar 21.

Division of Pediatric Urology, Riley Hospital for Children at Indiana University Health, Indianapolis, IN, USA.

Purpose: Despite devoting many resources to managing urinary and fecal incontinence (UI and FI) in children with spina bifida (SB), it remains unclear whether either is associated with lower health-related quality of life (HRQOL). We sought to determine the impact of UI and FI on HRQOL in this population.

Materials And Methods: Children with SB (8-17 years) living in the United States were surveyed online and in SB clinics (2013-15). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpurol.2018.02.021DOI Listing
June 2018
5 Reads

Tailored Strategies to Manage Cerebrospinal Fluid Leaks or Pseudomeningocele After Surgery for Tethered Cord Syndrome.

World Neurosurg 2018 Jun 29;114:e1049-e1056. Epub 2018 Mar 29.

Department of Neurosurgery, Amrita Institute of Medical Sciences and Research Centre, Amrita University, Kochi, Kerala, India.

Background: Cerebrospinal fluid (CSF) leaks are a dreaded complication after surgery for tethered cord and are associated with significant patient morbidity. Although many strategies for managing postoperative CSF leaks exist, this problem is still daunting, especially in very young patients. In this study, we compared different management techniques for CSF leaks or significant pseudomeningocele in patients with tethered cord syndrome (TCS). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S18788750183062
Publisher Site
http://dx.doi.org/10.1016/j.wneu.2018.03.144DOI Listing
June 2018
28 Reads

Bladder Management and Continence Outcomes in Adults with Spina Bifida: Results from the National Spina Bifida Patient Registry, 2009 to 2015.

J Urol 2018 07 26;200(1):187-194. Epub 2018 Mar 26.

Department of Urology, University of Alabama at Birmingham, Birmingham, Alabama.

Purpose: Most children with spina bifida now survive into adulthood, although most have neuropathic bladder with potential complications of incontinence, infection, renal damage and diminished quality of life. In this study we sought to 1) describe contemporary bladder management and continence outcomes of adults with spina bifida, 2) describe differences from younger individuals and 3) assess for association with socioeconomic factors.

Materials And Methods: We analyzed data on bladder management and outcomes in adults with spina bifida from the National Spina Bifida Patient Registry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.juro.2018.02.3101DOI Listing
July 2018
5 Reads

Donor mesenchymal stem cell linetics after transamniotic stem cell therapy (TRASCET) for experimental spina bifida.

J Pediatr Surg 2018 Jun 6;53(6):1134-1136. Epub 2018 Mar 6.

Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA. Electronic address:

Purpose: We sought to examine donor mesenchymal stem cell (MSC) kinetics after transamniotic stem cell therapy (TRASCET) in experimental spina bifida.

Methods: Pregnant Sprague-Dawley dams exposed to retinoic acid for the induction of fetal neural tube defects received volume-matched intra-amniotic injections on gestational day 17 (E17; term=E22): either amniotic fluid MSCs (afMSCs) labeled with a luciferase reporter gene (n=78), or luciferase protein alone (n=66). Samples from twelve organ systems from each surviving fetus with spina bifida (total n=60) were screened via microplate luminometry at term. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpedsurg.2018.02.067DOI Listing
June 2018
5 Reads

Intradetrusor Injections of Botulinum Toxin Type A in Children With Spina Bifida: A Multicenter Study.

Urology 2018 Jun 6;116:161-167. Epub 2018 Mar 6.

Department of Urology, University of Toulouse, Toulouse, France.

Objective: To assess the effectiveness of intradetrusor injections of botulinum toxin type A (IDBTX-A) in children with spina bifida.

Methods: All patients aged less than 16 years old who underwent IDBTX-A between 2002 and 2016 at 6 institutions were included in a retrospective study. Our primary endpoint was the success rate of IDBTX-A defined as both clinical improvement (no incontinence episodes between clean intermittent catheterizations [CICs], absence of urgency, and less than 8 CICs per day) and urodynamic improvement (resolution of detrusor overactivity and normal bladder compliance for age) lasting ≥12 weeks. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00904295183019
Publisher Site
http://dx.doi.org/10.1016/j.urology.2018.02.033DOI Listing
June 2018
18 Reads
2.190 Impact Factor

Advances and Challenges in Transitional Urology: Caring for Adolescents and Young Adults with Lifelong Complex Genitourinary Conditions.

Curr Urol Rep 2018 Mar 7;19(4):26. Epub 2018 Mar 7.

Division of Urology, University of Pennsylvania Health System, 3400 Civic Center Blvd, 3rd Floor - West Pavilion, Philadelphia, PA, 19104, USA.

Purpose Of Review: As long-term survival with complex congenital and pediatric diseases has improved, more patients with congenital genitourinary conditions are living into adulthood. These patients can continue to face lifelong issues related to their conditions, including urinary incontinence, recurrent urinary tract infections, chronic kidney disease, and difficulties with sexual health and function.

Recent Findings: The practice of transitional urology continues to grow nationwide and abroad, and it will be important to develop evidence-based practices for coordinated transition of these patients into the adult health care setting. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11934-018-0774-3DOI Listing
March 2018
2 Reads

Updates in fetal spina bifida repair.

Curr Opin Obstet Gynecol 2018 04;30(2):123-129

Department of Obstetrics and Gynecology, Baylor College of Medicine and Texas Children's Fetal Center, Houston, Texas, USA.

Purpose Of Review: To examine updates in fetal spina bifida surgical repair, as well as promising results emerging from translational medicine.

Recent Findings: Although the Management of Myelomeningocele Study sponsored by the National Institutes of Health helped establish the neonatal benefits of prenatal spina bifida repair via uterine hysterotomy, also known as 'open' fetal surgery, fetoscopic approaches may yield better maternal and obstetric outcomes.

Summary: Spina bifida is a severe congenital malformation associated with significant neonatal and childhood morbidity and mortality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/GCO.0000000000000443DOI Listing
April 2018
1 Read

Ultrasound in Prenatal Diagnostics and Its Impact on the Epidemiology of Spina Bifida in a National Cohort from Denmark with a Comparison to Sweden.

Biomed Res Int 2018 1;2018:9203985. Epub 2018 Feb 1.

Department of Gynecology and Obstetrics, Aarhus University Hospital, Aarhus, Denmark.

Objectives: The aim of this study was to assess the incidence, the prenatal detection rate by ultrasound, and the pregnancy outcome of spina bifida (SB) in Denmark (DK) in 2008-2015 and to compare results to national data from Sweden.

Methods: Data were retrieved from the Danish Fetal Medicine Database, which includes International Classification of Diseases- (ICD-) 10 codes for pre- or postnatally diagnoses and pregnancy outcome. Missing data were obtained from the National Patient Register. Read More

View Article

Download full-text PDF

Source
https://www.hindawi.com/journals/bmri/2018/9203985/
Publisher Site
http://dx.doi.org/10.1155/2018/9203985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816888PMC
August 2018
8 Reads

Intellectual efficiency in children and adolescents with spina bifida myelomeningocele and shunted hydrocephalus.

Dev Neuropsychol 2018 16;43(3):198-206. Epub 2018 Feb 16.

b Department of Dynamic and Clinical Psychology , Sapienza University of Rome , Rome , Italy.

We studied the intellectual profiles of 13 Italian children diagnosed with spina bifida myelomeningocele and shunted hydrocephalus (MMC HC) against a control group of children. The results showed that MMC HC group had lower performance in all subtests, four indices, and the FSIQ of the Wechsler Intelligence Scale for Children, forth-edition. The MMC HC group showed flat cognitive profiles between subtests within each index and between four core indices. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/87565641.2018.1
Publisher Site
http://dx.doi.org/10.1080/87565641.2018.1439035DOI Listing
June 2018
4 Reads

Care for Adults with Spina Bifida: Current State and Future Directions.

Top Spinal Cord Inj Rehabil 2017 ;23(2):155-167

Des Moines University College of Osteopathic Medicine, Des Moines, Iowa.

The care for adults with spina bifida is an important area to study. As increasing numbers of patients with spina bifida survive into adulthood, they expect to thrive and receive the best possible care into adulthood to maintain their health. Understanding the health needs in this emerging and changing population will help clinicians provide the best anticipatory care for adults with spina bifida and continue to improve outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1310/sci2302-155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672883PMC
August 2018
9 Reads

Ultrasound guided transversus abdominis plane block. Postoperative analgesia in children with spinal dysraphism.

Saudi Med J 2018 Jan;39(1):92-96

Department of Anesthesiology and Reanimation, Faculty of Medicine, Manisa Celal Bayar University, Manisa, Turkey. E-mail.

Pediatric regional anesthesia is widely used to relieve postoperative pain after abdominal surgery. Commonly used techniques of regional anesthesia include lumbar epidural and caudal block. However, the use of central neuraxial blockade has limitations. Read More

View Article

Download full-text PDF

Source
https://www.smj.org.sa/index.php/smj/article/view/smj.2018.1
Publisher Site
http://dx.doi.org/10.15537/smj.2018.1.20943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885127PMC
January 2018
24 Reads

Percutaneous fetoscopic closure of large open spina bifida using a bilaminar skin substitute.

Ultrasound Obstet Gynecol 2018 Oct;52(4):458-466

The USFetus Research Consortium, Miami, Florida, USA.

Objective: We have described previously our percutaneous fetoscopic technique for the treatment of open spina bifida (OSB). However, approximately 20-30% of OSB defects are too large to allow primary skin closure. Here we describe a modification of our standard technique using a bilaminar skin substitute to allow closure of large spinal defects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/uog.19001DOI Listing
October 2018
14 Reads

In utero Plastic Surgery in Zurich: Successful Use of Distally Pedicled Random Pattern Transposition Flaps for Definitive Skin Closure during Open Fetal Spina Bifida Repair.

Fetal Diagn Ther 2018 20;44(3):173-178. Epub 2017 Dec 20.

Zurich Center for Fetal Diagnosis and Therapy, University Children's Hospital Zurich, Zurich, Switzerland.

Background: One of the intraoperative challenges of fetal spina bifida repair is skin closure when there is an extended skin defect. Thus, we examined whether distally pedicled random pattern transposition flaps (TFs) are a valid option to overcome this problem.

Subjects And Methods: All patients undergoing in utero repair of spina bifida with application of a TF for back skin closure were analyzed focusing on intraoperative flap characteristics and postoperative flap performance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000479926DOI Listing
January 2019
9 Reads

How much do plastic surgeons add to the closure of myelomeningoceles?

Childs Nerv Syst 2018 04 8;34(4):737-740. Epub 2017 Dec 8.

Department of Paediatric Neurosurgery, University Hospital of Wales, Cardiff, UK.

Purpose: This study reviews the outcomes of children undergoing myelomeningocele (MMC) repair in the paediatric neurosurgical department in Cardiff. These procedures are historically performed by paediatric neurosurgeons with occasional support from plastic surgeons for the larger lesions. We reviewed the postoperative outcomes over a 9-year period to assess the efficacy of having a plastic surgeon present at all MMC closures. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00381-017-3674-9
Publisher Site
http://dx.doi.org/10.1007/s00381-017-3674-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856885PMC
April 2018
11 Reads
1.160 Impact Factor

Spina Bifida.

J Pediatr Rehabil Med 2017 12;10(3-4):165-166

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/PRM-170469DOI Listing
December 2017
8 Reads

Longitudinal Study of Bladder Continence in Patients with Spina Bifida in the National Spina Bifida Patient Registry.

J Urol 2018 03 11;199(3):837-843. Epub 2017 Nov 11.

Rare Disorders and Health Outcomes Team, Division of Human Development and Disability, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia.

Purpose: Achieving bladder continence in individuals with spina bifida is a lifetime management goal. We investigated bladder continence status through time and factors associated with this status in patients with spina bifida.

Materials And Methods: We used National Spina Bifida Patient Registry data collected from 2009 through 2015 and applied generalized estimating equation models to analyze factors associated with bladder continence status. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.juro.2017.11.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948157PMC
March 2018
7 Reads

Bowel management and continence in adults with spina bifida: Results from the National Spina Bifida Patient Registry 2009-15.

J Pediatr Rehabil Med 2017 12;10(3-4):335-343

Department of Urology, University of Alabama at Birmingham, Birmingham, AL, USA.

Introduction: Advances in care have allowed most children with spina bifida (SB) to live to adulthood. The majority have neuropathic bowel dysfunction (NBD), resulting in constipation, incontinence, and diminished quality of life. We sought to 1) describe contemporary NBD management and continence outcomes of adults with SB; 2) describe differences from younger patients; and 3) assess for association with socio-economic factors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/PRM-170466DOI Listing
December 2017
7 Reads

Early postnatal bladder function in fetoscopic myelomeningocele repair patients.

J Pediatr Rehabil Med 2017 12;10(3-4):327-333

Division of Urology, Department of Surgery, Texas Children's Hospital and Baylor College of Medicine, Houston, TX, USA.

Purpose: Prenatal repair of myelomeningocele (MMC) via hysterotomy has demonstrated neurosurgical and motor benefits, when compared to postnatal repairs. Urologic benefits, however, remain to be seen. The purpose of this study was to review early postnatal bladder function in patients undergoing a novel endoscopic approach for MMC repair using an exteriorized uterus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/PRM-170465DOI Listing
December 2017
11 Reads

Variation in surgical management of neurogenic bowel among centers participating in National Spina Bifida Patient Registry.

J Pediatr Rehabil Med 2017 12;10(3-4):303-312

Division of Urology, Duke University Medical Center, Durham, NC, USA.

Purpose: Optimal management of neurogenic bowel in patients with spina bifida (SB) remains controversial. Surgical interventions may be utilized to treat constipation and provide fecal continence, but their use may vary among SB treatment centers.

Methods: We queried the National Spina Bifida Patient Registry (NSBPR) to identify patients who underwent surgical interventions for neurogenic bowel. Read More

View Article

Download full-text PDF

Source
http://www.medra.org/servlet/aliasResolver?alias=iospress&am
Publisher Site
http://dx.doi.org/10.3233/PRM-170460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891120PMC
December 2017
9 Reads