1,402 results match your criteria Spinal Dysraphism Myelomeningocele


Lumbar Intramedullary Epidermoid Following Repair of Sacral Myelomeningocele and Tethered Cord: A Case Report With a Review of the Relevant Literature and Operative Nuances.

Neurospine 2018 Sep 4. Epub 2018 Sep 4.

Department of Neurosurgery, Kovai Medical Center and Hospital, Coimbatore, India.

Epidermoid cysts of the spine are rare tumors. While majority of them occur spontaneously, very few occur following a previous surgery for spinal dysraphism. Such tumors tend to occur at the site of previous surgery. Read More

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http://dx.doi.org/10.14245/ns.1836152.076DOI Listing
September 2018

Early start of clean intermittent catheterization versus expectant management in children with spina bifida.

J Pediatr Surg 2018 Nov 5. Epub 2018 Nov 5.

Department of Paediatric Urology, Royal Belfast Hospital for Sick Children, Northern Ireland.

Purpose: We instituted early clean intermittent catheterization (CIC) in 1997 for all newborn infants with spina bifida (SB). We compared this group to a historical group managed expectantly to see if early catheterization was associated with a reduction in renal scar rate as determined by DMSA scanning.

Methods: Data were studied retrospectively on all infants with SB over a recent 13-year period who were treated with early universal CIC in a regional pediatric urology department. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2018.10.096DOI Listing
November 2018
1 Read

Dynamic magnetic resonance imaging parameters for objective assessment of the magnitude of tethered cord syndrome in patients with spinal dysraphism.

Acta Neurochir (Wien) 2019 Jan 20;161(1):147-159. Epub 2018 Nov 20.

Department of Radiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Lucknow, 226014, India.

Background: Dynamic magnetic resonance imaging (MRI)-based criteria for diagnosing magnitude of tethered cord syndrome (TCS) in occult spinal dysraphism are proposed.

Methods: In this prospective, case-control design study, MRI lumbosacral spine was performed in 51 subjects [pilot group (n = 10) without TCS (for defining radiological parameters), control group (n = 10) without TCS (for baseline assessment), and study group (n = 31) with spinal dysraphism (thick filum terminale [n = 12], lumbar/lumbosacral meningomyelocoele [n = 6], and lipomyelomeningocoele [n = 13])]. The parameters compared in control and study groups included oscillatory frequency (OF), difference in ratio, in supine/prone position, of distance between posterior margin of vertebral body and anterior margin of spinal cord (oscillatory distance [OD]), with canal diameter, at the level of conus as well as superior border of contiguous two vertebrae above that level; delta bending angle (ΔBA), difference, in supine/prone position, of angle between longitudinal axis of conus and that of lower spinal cord; and sagittal and axial root angles, subtended between exiting ventral nerve roots and longitudinal axis of cord. Read More

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http://dx.doi.org/10.1007/s00701-018-3721-7DOI Listing
January 2019
11 Reads
1.788 Impact Factor

Ependyma-Lined Canal with Surrounding Neuroglial Tissues in Lumbosacral Lipomatous Malformations: Relationship with Retained Medullary Cord.

Pediatr Neurosurg 2018 2;53(6):387-394. Epub 2018 Nov 2.

Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: An ependyma-lined canal with surrounding neuroglial tissues can be present in lumbosacral lipomatous malformations; however, the precise embryological significance is still unclear.

Method: Six out of 50 patients with lipomatous malformations had ependymal structures. We retrospectively analyzed the clinical, neuroradiological, and histological findings of these patients to demonstrate the relationship with the embryological background of the retained medullary cord (RMC), which normally regresses, but was retained here because of late arrest of secondary neurulation. Read More

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http://dx.doi.org/10.1159/000494029DOI Listing
January 2019
1 Read

Can dynamic ultrasonography replace urodynamics in the follow-up of patients with myelomeningocele? A prospective concurrent study.

Neurourol Urodyn 2019 Jan 23;38(1):278-284. Epub 2018 Oct 23.

Department of Urology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.

Aims: To evaluate the accuracy of dynamic ultrasonography (DUS), as a feasible alternative diagnostic method to identify detrusor overactivity (DO) in patients with neurogenic bladder.

Methods: We performed concurrent analysis of 81 pairs of urodynamic study (UDS) and DUS, in 63 patients with myelomeningocele (MMC), from June 2014 to February 2017. The assessment focused on bladder behavior during the filling phase, DO evaluation, DO with leakage, compliance, and maximum cystometric capacity (MCC). Read More

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http://doi.wiley.com/10.1002/nau.23846
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http://dx.doi.org/10.1002/nau.23846DOI Listing
January 2019
9 Reads

Myelomeningocele Versus Myelocele on Fetal MR Images: Are There Differences in Brain Findings?

AJR Am J Roentgenol 2018 Dec 17;211(6):1376-1380. Epub 2018 Oct 17.

1 Department of Radiology and Medical Imaging, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229-3026.

Objective: The purpose of this study was to examine differences between patients with myelomeningocele and those with myelocele with respect to brain imaging findings at fetal MRI.

Materials And Methods: A single-center retrospective analysis was performed of fetal MRI examinations revealing open spinal dysraphism from 2004 through 2016 with available diagnostic postnatal spinal MR images in conjunction with neurosurgical follow-up findings. Images were reviewed by two board-certified fellowship-trained pediatric neuroradiologists. Read More

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https://www.ajronline.org/doi/10.2214/AJR.18.20088
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http://dx.doi.org/10.2214/AJR.18.20088DOI Listing
December 2018
12 Reads

Expression profiles of pro-inflammatory and pro-apoptotic mediators in secondary tethered cord syndrome after myelomeningocele repair surgery.

Childs Nerv Syst 2019 Feb 3;35(2):315-328. Epub 2018 Oct 3.

Department of Neurosurgery, University Hospital of Schleswig-Holstein Campus Kiel, Arnold-Heller-Str. 3, House 41, 24105, Kiel, Germany.

Purpose: The literature on histopathological and molecular changes that might underlie secondary tethered cord syndrome (TCS) after myelomeningocele (MMC) repair surgeries remains sparse. To address this problem, we analyzed specimens, which were obtained during untethering surgeries of patients who had a history of MMC repair surgery after birth.

Methods: Specimens of 12 patients were analyzed in this study. Read More

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http://dx.doi.org/10.1007/s00381-018-3984-6DOI Listing
February 2019
5 Reads

Spontaneous Pneumocephalus Secondary to Leaking Myelomeningocele.

J Pediatr Neurosci 2018 Jul-Sep;13(3):329-330

Department of Neurosurgery, Government Medical College, Thiruvananthapuram, Kerala, India.

Myelomeningocele is one among the most common forms of spinal dysraphism. We report a newborn male child with leaking myelomeningocele who presented with apneic spells. He underwent a magnetic resonance imaging of the neuraxis, which revealed Chiari malformation and severe hydromyelia along with pneumocephalus. Read More

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http://www.pediatricneurosciences.com/text.asp?2018/13/3/329
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http://dx.doi.org/10.4103/JPN.JPN_17_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144603PMC
October 2018
11 Reads

Improved Bowel Function in Patients with Spina Bifida After Bone Marrow-Derived Mononuclear Cell Transplantation: A Report of 2 Cases.

Am J Case Rep 2018 Aug 25;19:1010-1018. Epub 2018 Aug 25.

Stem Cell and Immune Cell Department, Vinmec Research Institute of Stem Cell and Gene Technology, Times City, Ha Noi, Vietnam.

BACKGROUND Bowel dysfunction is observed in 42.2-71.2% of patients with spina bifida. Read More

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https://www.amjcaserep.com/abstract/index/idArt/909801
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http://dx.doi.org/10.12659/AJCR.909801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120349PMC
August 2018
12 Reads

Caudal cell mass developmental aberrations: an imaging approach.

Clin Imaging 2018 Nov - Dec;52:216-225. Epub 2018 Jul 21.

University of Rochester Medical Center, Rochester, NY, USA.

The objective of this review is to describe antenatal and postnatal imaging criteria, which allow diagnosis and aid workup, prognostication and treatment of developmental anomalies of the caudal cell mass. The lower spinal cord (conus medullaris), filum terminale and inferior lumbar and sacral nerve roots develop from the caudal cell mass, a remnant of the embryologic primitive streak composed of undifferentiated pluripotential cells. Anomalous caudal cell mass development can manifest as tight filum terminale, caudal dysgenesis, terminal myelocystocele, anterior sacral meningocele or sacrococcygeal teratoma. Read More

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http://dx.doi.org/10.1016/j.clinimag.2018.07.014DOI Listing
January 2019
1 Read

Cerebral Diffusivity Changes in Fetuses with Chiari II Malformation.

Fetal Diagn Ther 2018 Aug 17:1-7. Epub 2018 Aug 17.

Divisions of Diagnostic Imaging and Radiology, Children's National Health System, and The George Washington University School of Medicine, Washington, District of Columbia, USA.

Objectives: Chiari II malformation is a congenital abnormality characterized by a small posterior fossa with downward displacement of the hindbrain into the foramen magnum. Diffusion-weighted imaging (DWI) can be used to quantitatively characterize brain injury and physiological maturation. We aim to evaluate DWI parameters of the infra- and supratentorial brain in fetuses with Chiari II malformation. Read More

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http://dx.doi.org/10.1159/000490102DOI Listing
August 2018
19 Reads

Fetal surgery for spina bifida aperta.

Arch Dis Child Fetal Neonatal Ed 2018 Nov 13;103(6):F589-F595. Epub 2018 Jul 13.

Academic Department Development and Regeneration, Cluster Woman and Child, Biomedical Sciences, Faculty of Medicine, Catholic University of Leuven, Leuven, Belgium.

Spina bifida aperta (SBA) is one of the most common congenital malformations. It can cause severe lifelong physical and neurodevelopmental disabilities. Experimental and clinical studies have shown that the neurological deficits associated with SBA are not simply caused by incomplete neurulation at the level of the lesion. Read More

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http://dx.doi.org/10.1136/archdischild-2018-315143DOI Listing
November 2018
7 Reads

Using subdural strip electrodes to define functional sensory nerves and the most inferior functional portion of the conus medullaris during detethering surgeries for tethered cord syndrome: a pilot study.

J Neurosurg Spine 2018 Oct 13;29(4):456-460. Epub 2018 Jul 13.

1Department of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital.

Objective: The aim of this study was to investigate the feasibility of using subdural strip electrodes, placed just rostral to the surgical field, to record sensory evoked potentials (SEPs) from the lumbosacral sensory nerves and define the most inferior functional portion of the conus medullaris during detethering surgery for spinal dysraphism and/or tethered cord syndrome (TCS).

Methods: Six patients, 2 boys and 4 girls, aged 0.5 to 16 years, were enrolled in this study. Read More

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http://dx.doi.org/10.3171/2018.2.SPINE171240DOI Listing
October 2018
2 Reads

Prenatal diagnosis of closed spina bifida: multicenter case series and review of the literature.

J Matern Fetal Neonatal Med 2018 Sep 6:1-7. Epub 2018 Sep 6.

a Department of Obstetrics, Paulista School of Medicine , Federal University of São Paulo (EPM-UNIFESP) , São Paulo , Brazil.

Objective: Closed spina bifida (CSB) is an abnormality of the posterior arch formation in which the defect is covered by the skin, without protrusion of nervous tissue. The prenatal diagnosis of CSB is very difficult, rarely diagnosed antenatally.

Methods: We present a multicenter case series of six prenatal diagnosis of CSB using two-dimensional (2D) ultrasonography complemented with three-dimensional (3D) ultrasonography and magnetic resonance imaging (MRI). Read More

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http://dx.doi.org/10.1080/14767058.2018.1500543DOI Listing
September 2018
30 Reads

Cystic Cervical Dysraphism: Experience of 12 Cases.

J Pediatr Neurosci 2018 Jan-Mar;13(1):39-45

Department of Neurosurgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Introduction: Cystic spinal dysraphism of the cervical region is a relatively rare entity, which is more frequently associated with congenital anomalies such as split cord malformation, Chiari malformation, and corpus callosum agenesis, when compared to their lumbosacral counterpart. In our study, we have highlighted the clinical spectrum, associated anomalies (both neural and extra-neural), and surgical nuances of these.

Materials And Methods: This study is a retrospective analysis of 225 patients from June 2010 to April 2017. Read More

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http://dx.doi.org/10.4103/JPN.JPN_30_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982491PMC
June 2018
4 Reads

Homologous cryopreserved amniotic membrane in the repair of myelomeningocele: preliminary experience.

Acta Neurochir (Wien) 2018 Aug 1;160(8):1625-1631. Epub 2018 Jun 1.

Department of Neurosurgery, Treviso Hospital, University of Padova, Via Piazzale 1, 31100, Padova, Treviso, Italy.

Objective: Surgical management of spinal dysraphism often requires the use of dural substitutes. Amniotic membrane (AM) has drawn the interest of clinicians for its valuable concentration of cytokines and factors capable of promoting wound healing, re-epithelialization, inhibiting fibrosis and regulating angiogenesis. These beneficial qualities could make AM an interesting dural substitute for spina bifida repair. Read More

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http://dx.doi.org/10.1007/s00701-018-3577-xDOI Listing
August 2018
3 Reads
1.790 Impact Factor

The Prevalence of Scoliosis in Spina Bifida Subpopulations: A Systematic Review.

Am J Phys Med Rehabil 2018 Nov;97(11):848-854

From Physical and Rehabilitation Medicine, University Hospitals Leuven, Leuven, Belgium (AH, KP, CK); Clinical and Experimental Sciences Department, University of Brescia, Brescia, Italy (SN); IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy (SN); Department of Development and Regeneration, University Hospitals Leuven, Leuven, Belgium (KJ); and Orthopaedic Surgery, University Hospitals Leuven, Leuven, Belgium (PM, SS).

Prevalence of scoliosis within spina bifida subpopulations is important for diagnostics and therapeutic purposes. This review determined the prevalence of scoliosis within spina bifida subpopulations by means of a systematic literature review by using the following databases: Medline PubMed, Embase, Cochrane, and Pedro. All Dutch- and English-written literature using the MESH terms "spinal dysraphism," "neural tube defects," and "scoliosis" was analyzed using the exclusion criteria: animal studies, case reports, studies regarding the prevalence of spina bifida among patients with scoliosis, studies with inclusion of patients with scoliosis of less than 11 degrees without possibility to identify subgroups with scoliosis of greater than 10 degrees, studies without an own study group, articles comprising the same patient group as another article, neural tube defects besides spina bifida, and articles without specification of spina bifida subtype. Read More

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http://dx.doi.org/10.1097/PHM.0000000000000966DOI Listing
November 2018
2 Reads

Adult Versus Pediatric Tethered Cord Syndrome: Clinicoradiological Differences and its Management.

Asian J Neurosurg 2018 Apr-Jun;13(2):264-270

Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Background: Dysraphic lesions in adults, presenting clinically as tethered cord syndrome (TCS), are relatively rare, and their optimal management remains controversial.

Patients And Methods: We performed a retrospective analysis of our pediatric database over a period of last 7 years to focus on the adult TCS. Our aim was to determine the clinicoradiological and etiopathological differences between adult and pediatric patients as well as to determine the results of surgery in adult TCS. Read More

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http://www.asianjns.org/text.asp?2018/13/2/264/228566
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http://dx.doi.org/10.4103/1793-5482.228566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898090PMC
April 2018
29 Reads

Acute Communicating Hydrocephalus as Spinal Cord Surgery Complication in Patient with Lumbar Lipomyelocele.

World Neurosurg 2018 Jul 17;115:468-472.e2. Epub 2018 Apr 17.

Department of Neurosurgery, Istituto Giannina Gaslini, Genoa, Italy.

Background: A lumbar lipomyelocele is a closed spinal dysraphism that can cause tethered cord syndrome. Between 5% and 15% of spinal dysraphism surgery cases are burdened with complications, the most common being wound infections or dehiscence and cerebrospinal fluid leak. Acute communicating hydrocephalus has never been described as a complication of this type of surgery. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.04.052DOI Listing
July 2018
13 Reads

Incontinence affects health-related quality of life in children and adolescents with spina bifida.

J Pediatr Urol 2018 Jun 21;14(3):279.e1-279.e8. Epub 2018 Mar 21.

Division of Pediatric Urology, Riley Hospital for Children at Indiana University Health, Indianapolis, IN, USA.

Purpose: Despite devoting many resources to managing urinary and fecal incontinence (UI and FI) in children with spina bifida (SB), it remains unclear whether either is associated with lower health-related quality of life (HRQOL). We sought to determine the impact of UI and FI on HRQOL in this population.

Materials And Methods: Children with SB (8-17 years) living in the United States were surveyed online and in SB clinics (2013-15). Read More

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http://dx.doi.org/10.1016/j.jpurol.2018.02.021DOI Listing
June 2018
5 Reads

Tailored Strategies to Manage Cerebrospinal Fluid Leaks or Pseudomeningocele After Surgery for Tethered Cord Syndrome.

World Neurosurg 2018 Jun 29;114:e1049-e1056. Epub 2018 Mar 29.

Department of Neurosurgery, Amrita Institute of Medical Sciences and Research Centre, Amrita University, Kochi, Kerala, India.

Background: Cerebrospinal fluid (CSF) leaks are a dreaded complication after surgery for tethered cord and are associated with significant patient morbidity. Although many strategies for managing postoperative CSF leaks exist, this problem is still daunting, especially in very young patients. In this study, we compared different management techniques for CSF leaks or significant pseudomeningocele in patients with tethered cord syndrome (TCS). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183062
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http://dx.doi.org/10.1016/j.wneu.2018.03.144DOI Listing
June 2018
27 Reads

Bladder Management and Continence Outcomes in Adults with Spina Bifida: Results from the National Spina Bifida Patient Registry, 2009 to 2015.

J Urol 2018 Jul 26;200(1):187-194. Epub 2018 Mar 26.

Department of Urology, University of Alabama at Birmingham, Birmingham, Alabama.

Purpose: Most children with spina bifida now survive into adulthood, although most have neuropathic bladder with potential complications of incontinence, infection, renal damage and diminished quality of life. In this study we sought to 1) describe contemporary bladder management and continence outcomes of adults with spina bifida, 2) describe differences from younger individuals and 3) assess for association with socioeconomic factors.

Materials And Methods: We analyzed data on bladder management and outcomes in adults with spina bifida from the National Spina Bifida Patient Registry. Read More

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http://dx.doi.org/10.1016/j.juro.2018.02.3101DOI Listing
July 2018
4 Reads

Donor mesenchymal stem cell linetics after transamniotic stem cell therapy (TRASCET) for experimental spina bifida.

J Pediatr Surg 2018 Jun 6;53(6):1134-1136. Epub 2018 Mar 6.

Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA. Electronic address:

Purpose: We sought to examine donor mesenchymal stem cell (MSC) kinetics after transamniotic stem cell therapy (TRASCET) in experimental spina bifida.

Methods: Pregnant Sprague-Dawley dams exposed to retinoic acid for the induction of fetal neural tube defects received volume-matched intra-amniotic injections on gestational day 17 (E17; term=E22): either amniotic fluid MSCs (afMSCs) labeled with a luciferase reporter gene (n=78), or luciferase protein alone (n=66). Samples from twelve organ systems from each surviving fetus with spina bifida (total n=60) were screened via microplate luminometry at term. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2018.02.067DOI Listing
June 2018
4 Reads

Intradetrusor Injections of Botulinum Toxin Type A in Children With Spina Bifida: A Multicenter Study.

Urology 2018 Jun 6;116:161-167. Epub 2018 Mar 6.

Department of Urology, University of Toulouse, Toulouse, France.

Objective: To assess the effectiveness of intradetrusor injections of botulinum toxin type A (IDBTX-A) in children with spina bifida.

Methods: All patients aged less than 16 years old who underwent IDBTX-A between 2002 and 2016 at 6 institutions were included in a retrospective study. Our primary endpoint was the success rate of IDBTX-A defined as both clinical improvement (no incontinence episodes between clean intermittent catheterizations [CICs], absence of urgency, and less than 8 CICs per day) and urodynamic improvement (resolution of detrusor overactivity and normal bladder compliance for age) lasting ≥12 weeks. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00904295183019
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http://dx.doi.org/10.1016/j.urology.2018.02.033DOI Listing
June 2018
15 Reads
2.190 Impact Factor

Advances and Challenges in Transitional Urology: Caring for Adolescents and Young Adults with Lifelong Complex Genitourinary Conditions.

Curr Urol Rep 2018 Mar 7;19(4):26. Epub 2018 Mar 7.

Division of Urology, University of Pennsylvania Health System, 3400 Civic Center Blvd, 3rd Floor - West Pavilion, Philadelphia, PA, 19104, USA.

Purpose Of Review: As long-term survival with complex congenital and pediatric diseases has improved, more patients with congenital genitourinary conditions are living into adulthood. These patients can continue to face lifelong issues related to their conditions, including urinary incontinence, recurrent urinary tract infections, chronic kidney disease, and difficulties with sexual health and function.

Recent Findings: The practice of transitional urology continues to grow nationwide and abroad, and it will be important to develop evidence-based practices for coordinated transition of these patients into the adult health care setting. Read More

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http://dx.doi.org/10.1007/s11934-018-0774-3DOI Listing
March 2018
1 Read

Ultrasound in Prenatal Diagnostics and Its Impact on the Epidemiology of Spina Bifida in a National Cohort from Denmark with a Comparison to Sweden.

Biomed Res Int 2018 1;2018:9203985. Epub 2018 Feb 1.

Department of Gynecology and Obstetrics, Aarhus University Hospital, Aarhus, Denmark.

Objectives: The aim of this study was to assess the incidence, the prenatal detection rate by ultrasound, and the pregnancy outcome of spina bifida (SB) in Denmark (DK) in 2008-2015 and to compare results to national data from Sweden.

Methods: Data were retrieved from the Danish Fetal Medicine Database, which includes International Classification of Diseases- (ICD-) 10 codes for pre- or postnatally diagnoses and pregnancy outcome. Missing data were obtained from the National Patient Register. Read More

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https://www.hindawi.com/journals/bmri/2018/9203985/
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http://dx.doi.org/10.1155/2018/9203985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816888PMC
August 2018
6 Reads

Intellectual efficiency in children and adolescents with spina bifida myelomeningocele and shunted hydrocephalus.

Dev Neuropsychol 2018 16;43(3):198-206. Epub 2018 Feb 16.

b Department of Dynamic and Clinical Psychology , Sapienza University of Rome , Rome , Italy.

We studied the intellectual profiles of 13 Italian children diagnosed with spina bifida myelomeningocele and shunted hydrocephalus (MMC HC) against a control group of children. The results showed that MMC HC group had lower performance in all subtests, four indices, and the FSIQ of the Wechsler Intelligence Scale for Children, forth-edition. The MMC HC group showed flat cognitive profiles between subtests within each index and between four core indices. Read More

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https://www.tandfonline.com/doi/full/10.1080/87565641.2018.1
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http://dx.doi.org/10.1080/87565641.2018.1439035DOI Listing
June 2018
4 Reads

Care for Adults with Spina Bifida: Current State and Future Directions.

Top Spinal Cord Inj Rehabil 2017 ;23(2):155-167

Des Moines University College of Osteopathic Medicine, Des Moines, Iowa.

The care for adults with spina bifida is an important area to study. As increasing numbers of patients with spina bifida survive into adulthood, they expect to thrive and receive the best possible care into adulthood to maintain their health. Understanding the health needs in this emerging and changing population will help clinicians provide the best anticipatory care for adults with spina bifida and continue to improve outcomes. Read More

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http://dx.doi.org/10.1310/sci2302-155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672883PMC
August 2018
9 Reads

Ultrasound guided transversus abdominis plane block. Postoperative analgesia in children with spinal dysraphism.

Saudi Med J 2018 Jan;39(1):92-96

Department of Anesthesiology and Reanimation, Faculty of Medicine, Manisa Celal Bayar University, Manisa, Turkey. E-mail.

Pediatric regional anesthesia is widely used to relieve postoperative pain after abdominal surgery. Commonly used techniques of regional anesthesia include lumbar epidural and caudal block. However, the use of central neuraxial blockade has limitations. Read More

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https://www.smj.org.sa/index.php/smj/article/view/smj.2018.1
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http://dx.doi.org/10.15537/smj.2018.1.20943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885127PMC
January 2018
22 Reads

Percutaneous fetoscopic closure of large open spina bifida using a bilaminar skin substitute.

Ultrasound Obstet Gynecol 2018 Oct;52(4):458-466

The USFetus Research Consortium, Miami, Florida, USA.

Objective: We have described previously our percutaneous fetoscopic technique for the treatment of open spina bifida (OSB). However, approximately 20-30% of OSB defects are too large to allow primary skin closure. Here we describe a modification of our standard technique using a bilaminar skin substitute to allow closure of large spinal defects. Read More

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http://dx.doi.org/10.1002/uog.19001DOI Listing
October 2018
11 Reads

In utero Plastic Surgery in Zurich: Successful Use of Distally Pedicled Random Pattern Transposition Flaps for Definitive Skin Closure during Open Fetal Spina Bifida Repair.

Fetal Diagn Ther 2018 20;44(3):173-178. Epub 2017 Dec 20.

Zurich Center for Fetal Diagnosis and Therapy, University Children's Hospital Zurich, Zurich, Switzerland.

Background: One of the intraoperative challenges of fetal spina bifida repair is skin closure when there is an extended skin defect. Thus, we examined whether distally pedicled random pattern transposition flaps (TFs) are a valid option to overcome this problem.

Subjects And Methods: All patients undergoing in utero repair of spina bifida with application of a TF for back skin closure were analyzed focusing on intraoperative flap characteristics and postoperative flap performance. Read More

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http://dx.doi.org/10.1159/000479926DOI Listing
January 2019
9 Reads

How much do plastic surgeons add to the closure of myelomeningoceles?

Childs Nerv Syst 2018 Apr 8;34(4):737-740. Epub 2017 Dec 8.

Department of Paediatric Neurosurgery, University Hospital of Wales, Cardiff, UK.

Purpose: This study reviews the outcomes of children undergoing myelomeningocele (MMC) repair in the paediatric neurosurgical department in Cardiff. These procedures are historically performed by paediatric neurosurgeons with occasional support from plastic surgeons for the larger lesions. We reviewed the postoperative outcomes over a 9-year period to assess the efficacy of having a plastic surgeon present at all MMC closures. Read More

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http://dx.doi.org/10.1007/s00381-017-3674-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856885PMC
April 2018
6 Reads
1.160 Impact Factor

Spina Bifida.

J Pediatr Rehabil Med 2017 12;10(3-4):165-166

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http://dx.doi.org/10.3233/PRM-170469DOI Listing
December 2017
8 Reads

Longitudinal Study of Bladder Continence in Patients with Spina Bifida in the National Spina Bifida Patient Registry.

J Urol 2018 Mar 11;199(3):837-843. Epub 2017 Nov 11.

Rare Disorders and Health Outcomes Team, Division of Human Development and Disability, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia.

Purpose: Achieving bladder continence in individuals with spina bifida is a lifetime management goal. We investigated bladder continence status through time and factors associated with this status in patients with spina bifida.

Materials And Methods: We used National Spina Bifida Patient Registry data collected from 2009 through 2015 and applied generalized estimating equation models to analyze factors associated with bladder continence status. Read More

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http://dx.doi.org/10.1016/j.juro.2017.11.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948157PMC
March 2018
6 Reads

Bowel management and continence in adults with spina bifida: Results from the National Spina Bifida Patient Registry 2009-15.

J Pediatr Rehabil Med 2017 12;10(3-4):335-343

Department of Urology, University of Alabama at Birmingham, Birmingham, AL, USA.

Introduction: Advances in care have allowed most children with spina bifida (SB) to live to adulthood. The majority have neuropathic bowel dysfunction (NBD), resulting in constipation, incontinence, and diminished quality of life. We sought to 1) describe contemporary NBD management and continence outcomes of adults with SB; 2) describe differences from younger patients; and 3) assess for association with socio-economic factors. Read More

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http://dx.doi.org/10.3233/PRM-170466DOI Listing
December 2017
6 Reads

Early postnatal bladder function in fetoscopic myelomeningocele repair patients.

J Pediatr Rehabil Med 2017 12;10(3-4):327-333

Division of Urology, Department of Surgery, Texas Children's Hospital and Baylor College of Medicine, Houston, TX, USA.

Purpose: Prenatal repair of myelomeningocele (MMC) via hysterotomy has demonstrated neurosurgical and motor benefits, when compared to postnatal repairs. Urologic benefits, however, remain to be seen. The purpose of this study was to review early postnatal bladder function in patients undergoing a novel endoscopic approach for MMC repair using an exteriorized uterus. Read More

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http://dx.doi.org/10.3233/PRM-170465DOI Listing
December 2017
11 Reads

Variation in surgical management of neurogenic bowel among centers participating in National Spina Bifida Patient Registry.

J Pediatr Rehabil Med 2017 12;10(3-4):303-312

Division of Urology, Duke University Medical Center, Durham, NC, USA.

Purpose: Optimal management of neurogenic bowel in patients with spina bifida (SB) remains controversial. Surgical interventions may be utilized to treat constipation and provide fecal continence, but their use may vary among SB treatment centers.

Methods: We queried the National Spina Bifida Patient Registry (NSBPR) to identify patients who underwent surgical interventions for neurogenic bowel. Read More

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/PRM-170460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891120PMC
December 2017
9 Reads

Daily time management in children with spina bifida.

J Pediatr Rehabil Med 2017 12;10(3-4):295-302

Institute of Neuroscience and Physiology at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Purpose: Spina bifida (SB) often results in a complex disability and can also cause cognitive dysfunction. No previous study has investigated the ability to adapt to time in children with SB. This ability is crucial for an individual's possibility to develop autonomy in life. Read More

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http://dx.doi.org/10.3233/PRM-170459DOI Listing
December 2017
4 Reads

Evaluation of spina bifida transitional care practices in the United States.

J Pediatr Rehabil Med 2017 12;10(3-4):275-281

Department of Surgery, Duke Medicine, Durham, NC, USA.

Purpose: Recent studies have revealed that the lack of continuity in preparing patients with spina bifida to transition into adult-centered care may have detrimental health consequences. We sought to describe current practices of transitional care services offered at spina bifida clinics in the US.

Methods: Survey design followed the validated transitional care survey by the National Cystic Fibrosis center. Read More

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http://dx.doi.org/10.3233/PRM-170455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896760PMC
December 2017
3 Reads

Endoscopic Third Ventriculostomy to address hydrocephalus in Africa: A call for education and community-based rehabilitation.

J Pediatr Rehabil Med 2017 12;10(3-4):267-273

Developmental and Behavioral Pediatrics, Department of Pediatrics, Texas Children's Hospital - Baylor College of Medicine, Houston, TX, USA.

Purpose: Endoscopic Third Ventriculostomy (ETV) and Choroid Plexus Cautery (CPC) are low-cost, safe, and promising interventions for spina bifida-associated hydrocephalus (SBHCP). The purpose of this review was to explore and describe these efforts in Africa in order to upscale surgical training and rehabilitation services.

Methods: A PubMed search for articles on ETV and CPC as management of SBHCP in Africa was performed. Read More

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http://dx.doi.org/10.3233/PRM-170454DOI Listing
December 2017
3 Reads

Crowdsourcing utility estimation for spina bifida in the general population.

J Pediatr Rehabil Med 2017 12;10(3-4):257-266

Division of Urologic Surgery, Duke University Medical Center, Durham, NC, USA.

Introduction: Cost-utility analyses (CUA) are useful when the treatment conditions depend on patient preferences that are in turn dependent on health state utility value. Spina bifida (SB) is an example of such a preference-sensitive condition. Historically, the SB utility value for CUA has been gathered via a traditional face-to-face interview. Read More

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http://dx.doi.org/10.3233/PRM-170453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901659PMC
December 2017

Effect of bladder augmentation on VP shunt failure rates in spina bifida.

J Pediatr Rehabil Med 2017 12;10(3-4):249-255

Center for Surgical Outcomes Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.

Purpose: Most patients with spina bifida require ventriculoperitoneal (VP) shunt placement. Some also require bladder augmentation, which may increase the risk of VP shunt malfunction and/or failure. The aim of this study was to assess whether bladder augmentation affects the rate of VP shunt failure in this population. Read More

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http://dx.doi.org/10.3233/PRM-170452DOI Listing
December 2017
1 Read

Variation in bowel and bladder continence across US spina bifida programs: A descriptive study.

J Pediatr Rehabil Med 2017 12;10(3-4):231-241

Department of Pediatrics, University of Washington School of Medicine and Seattle Children's Hospital, Seattle, WA, USA.

Purpose: Continence is low in individuals with spina bifida, but published prevalence varies markedly across studies. The objective of this study was to examine bladder and bowel continence among patients served by multidisciplinary clinics participating in the National Spina Bifida Patient Registry and to examine whether variation in prevalence exists across clinics.

Methods: Data were obtained from patients 5 years and older from March 2009 to December 2012. Read More

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http://dx.doi.org/10.3233/PRM-170450DOI Listing
December 2017
7 Reads

Urologic self-management through intermittent self-catheterization among individuals with spina bifida: A journey to self-efficacy and autonomy.

J Pediatr Rehabil Med 2017 12;10(3-4):219-226

Developmental Pediatrics, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.

Purpose: To describe the age of independence in intermittent self-catheterization (ISC) in a diverse patient population and identify factors associated with ISC in individuals with spina bifida.

Methods: Two hundred patients with myelomeningocele or lipomyelomeningocele, who were ⩾ 3 years of age and utilized catheterization for bladder management were included. Data regarding diagnosis, functional level of lesion, race, ethnicity, presence of shunt, method of catheterization, self-management skills, fine motor skills, and cognitive abilities were collected. Read More

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http://dx.doi.org/10.3233/PRM-170447DOI Listing
December 2017
8 Reads

Ambulatory Care Use among Patients with Spina Bifida: Change in Care from Childhood to Adulthood.

J Urol 2018 Apr 4;199(4):1050-1055. Epub 2017 Nov 4.

Division of Neurourology and Pelvic Reconstruction, University of Michigan, Ann Arbor, Michigan.

Purpose: We examined the ambulatory health care visit use of children with spina bifida, adults who transitioned to adult care and adults who continued to seek care in a pediatric setting.

Materials And Methods: We evaluated use during a 1-year period of patients with spina bifida who visited any outpatient medical clinic within an integrated health care system. Patients were categorized as pediatric (younger than 18 years) or adult (age 18 or older). Read More

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http://dx.doi.org/10.1016/j.juro.2017.10.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897162PMC
April 2018
2 Reads

Validation of QUALAS-T, a health-related quality of life instrument for teenagers with spina bifida.

Cent European J Urol 2017 23;70(3):306-313. Epub 2017 Jun 23.

Division of Pediatric Urology, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Introduction: We aimed to develop and validate a self-reported QUAlity of Life Assessment in Spina bifida for Teenagers (QUALAS-T).

Material And Methods: We drafted a 46-question pilot instrument using a patient-centered comprehensive item generation/refinement process. A group of 13-17 years olds with spina bifida (SB) was recruited online via social media and in person at SB clinics (2013-2015). Read More

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http://dx.doi.org/10.5173/ceju.2017.1195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656361PMC
June 2017
10 Reads

Retained medullary cord extending to a sacral subcutaneous meningocele.

Childs Nerv Syst 2018 Mar 3;34(3):527-533. Epub 2017 Nov 3.

Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: A retained medullary cord (RMC) is a rare closed spinal dysraphism with a robust elongated neural structure continuous from the conus and extending to the dural cul-de-sac. One case extending down to the base of a subcutaneous meningocele at the sacral level has been reported.

Clinical Presentation: We report on three cases of closed spinal dysraphism, in which a spinal cord-like tethering structure extended out from the dural cul-de-sac and terminated at a skin-covered meningocele sac in the sacrococcygeal region, which was well delineated in curvilinear coronal reconstructed images of 3D-heavily T2-weighted images (3D-hT2WI). Read More

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http://link.springer.com/10.1007/s00381-017-3644-2
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http://dx.doi.org/10.1007/s00381-017-3644-2DOI Listing
March 2018
3 Reads

Postnatal Management of Myelomeningocele: Outcome with a Multidisciplinary Team Experience.

World Neurosurg 2018 Feb 5;110:e24-e31. Epub 2017 Oct 5.

Department of Pediatric Neurosurgery, Hôpital Femme Mère Enfant, Lyon Cedex, France. Electronic address:

Introduction: Myelomeningocele (MMC) is a complex neural tube defect. Few studies report the results of modern postnatal management. The goal of this study was to report the long-term outcome of a multidisciplinary approach of patients with MMC. Read More

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http://dx.doi.org/10.1016/j.wneu.2017.09.169DOI Listing
February 2018
16 Reads

A case of prenatally diagnosed limited dorsal myeloschisis with good prognosis.

J Clin Ultrasound 2018 May 5;46(4):282-285. Epub 2017 Oct 5.

Department of Obstetrics and Gynecology, University Hospital, Caen, France.

Diagnosis of fetal spinal dysraphism is a challenge. It is difficult to distinguish between a meningocele, myelomeningocele, and a recently described entity called limited dorsal myeloschisis (LDM). Although myelomeningocele is associated with a poor prognosis, LDM can have a good outcome. Read More

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http://dx.doi.org/10.1002/jcu.22527DOI Listing
May 2018
8 Reads

Split Notochord Syndrome: A Rare Variant.

J Pediatr Neurosci 2017 Apr-Jun;12(2):177-179

Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India.

Split notochord syndrome represents an extremely rare and pleomorphic form of spinal dysraphism characterized by a persistent communication between the endoderm and the ectoderm, resulting in splitting or deviation of the notochord. It manifests as a cleft in the dorsal midline of the body through which intestinal loops are exteriorized and even myelomeningoceles or teratomas may occur at the site. A rare variant was diagnosed on autopsy of a 23-week-old fetus showing a similar dorsal enteric fistula and midline protruding intestinal loops in thoracolumbar region. Read More

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http://dx.doi.org/10.4103/jpn.JPN_120_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588648PMC
September 2017
11 Reads