2,480 results match your criteria Spinal Cord Trauma and Related Diseases

Characterization of Ex Vivo and In Vitro Wnt Transcriptome Induced by Spinal Cord Injury in Rat Microglial Cells.

Brain Sci 2022 May 30;12(6). Epub 2022 May 30.

Laboratory of Molecular Neurology, Hospital Nacional de Parapléjicos, 45004 Toledo, Spain.

It is well known that inflammation is crucial in the onset and progression of neurodegenerative diseases and traumatic central nervous system (CNS) injuries, and that microglia and monocyte-derived macrophages (MDMs) play a pivotal role in neuroinflammation. Therefore, the exploration of molecular signaling pathways that are involved in the microglia/macrophage response might help us to shed light on their eventual therapeutic modulation. Interestingly, there is growing evidence showing that the Wnt family of proteins is involved in different neuropathologies that are characterized by a dysregulated neuroinflammatory response, including spinal cord injury (SCI). Read More

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Positive interaction between GPER and β-alanine in the dorsal root ganglion uncovers potential mechanisms: mediating continuous neuronal sensitization and neuroinflammation responses in neuropathic pain.

J Neuroinflammation 2022 Jun 21;19(1):164. Epub 2022 Jun 21.

Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Background: The pathogenesis of neuropathic pain and the reasons for the prolonged unhealing remain unknown. Increasing evidence suggests that sex oestrogen differences play a role in pain sensitivity, but few studies have focused on the oestrogen receptor which may be an important molecular component contributing to peripheral pain transduction. We aimed to investigate the impact of oestrogen receptors on the nociceptive neuronal response in the dorsal root ganglion (DRG) and spinal dorsal horn using a spared nerve injury (SNI) rat model of chronic pain. Read More

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Identification of novel multipotent stem cells in mouse spinal cord following traumatic injury.

Stem Cells Dev 2022 Jun 16. Epub 2022 Jun 16.

Hyogo College of Medicine, 12818, Neurosurgery, Nishinomiya, Japan.

We showed that injury-induced multipotent stem cells (iSCs) emerge in the brain after stroke. These brain-derived iSCs (B-iSCs) can differentiate into various lineages, including neurons. This study aimed to determine whether similar stem cells can be induced even after non-ischemic injuries, such as trauma to the spinal cord. Read More

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Traditional Chinese medicine active ingredients-based selenium nanoparticles regulate antioxidant selenoproteins for spinal cord injury treatment.

J Nanobiotechnology 2022 Jun 14;20(1):278. Epub 2022 Jun 14.

Department of Chemistry, Jinan University, Guangzhou, 510632, China.

Background: As Traditional Chinese Medicine (TCM) drugs, Huangqi and Danshen are always applied in combination for spinal cord injury (SCI) treatment based on the compatibility theory of TCM. Astragalus Polysaccharidesis (APS) and Tanshinone IIA (TSIIA) are the main active ingredients of Huangqi and Danshen, and they both possess neuroprotective effects through antioxidant activities. However, low solubility and poor bioavailability have greatly limited their application. Read More

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Association of bladder trabeculation and neurogenic bladder with spinal cord injury.

J Int Med Res 2022 Jun;50(6):3000605221104768

Department of Physical Medicine and Rehabilitation, Jeonbuk National University Medical School, Jeonju, Republic of Korea.

Objective: To compare clinical findings and urodynamic parameters according to trabeculation grade and analyze their correlations with trabeculation severity in neurogenic bladder caused by suprasacral spinal cord injury (SCI).

Methods: A retrospective chart review was performed of neurogenic bladder caused by SCI. Bladder trabeculation grade was compared with SCI-related clinical parameters and bladder-related urodynamic parameters. Read More

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Human temperature regulation under heat stress in health, disease, and injury.

Physiol Rev 2022 Jun 9. Epub 2022 Jun 9.

Internal Medicine, Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas and University of Texas Southwestern Medical Center, Dallas, Texas, United States.

The human body constantly exchanges heat with the environment. Temperature regulation is a homeostatic feedback control system that ensures deep body temperature is maintained within narrow limits despite wide variations in environmental conditions and activity-related elevations in metabolic heat production. Extensive research has been performed to study the physiological regulation of deep body temperature. Read More

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Astrocytic Nrf2 expression protects spinal cord from oxidative stress following spinal cord injury in a male mouse model.

J Neuroinflammation 2022 Jun 6;19(1):134. Epub 2022 Jun 6.

Institute of Neuroanatomy, Uniklinik RWTH Aachen, Aachen, Germany.

Background: Spinal cord injury (SCI) induces a multitude of deleterious processes, including neuroinflammation and oxidative stress (OS) which contributed to neuronal damage and demyelination. Recent studies have suggested that increased formation of reactive oxygen species (ROS) and the consequent OS are critical events associated with SCI. However, there is still little information regarding the impact of these events on SCI. Read More

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Vertebral arteriovenous fistula due to blunt neck trauma: A case report.

Ulus Travma Acil Cerrahi Derg 2022 Jun;28(6):871-875

Department of Neurosurgery, Ordu University Faculty of Medicine, Ordu-Turkey.

The arteriovenous fistulas (AVFs) of the vertebral artery are usually caused by iatrogenic and penetrating traumas. Vertebral AVF is rarely seen after blunt cervical trauma. A 65-year-old male patient applied to the emergency clinic due to falling from a height of about 3 m. Read More

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The relationship of secondary and chronic health conditions with emergency department visits and related hospitalizations among people with traumatic spinal cord injury.

Arch Phys Med Rehabil 2022 May 26. Epub 2022 May 26.

College of Health Professions, Medical University of South Carolina, Charleston, SC, USA.

Objective: Identify the relationship of health conditions with self-reported emergency department (ED) visits and ED related hospitalizations among people with traumatic spinal cord injury (SCI), while controlling for demographic, injury, and socioeconomic factors.

Design: Cross-sectional.

Setting: A regional SCI model system in the Southeastern United States. Read More

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The Role of miRNAs in Dexmedetomidine's Neuroprotective Effects against Brain Disorders.

Int J Mol Sci 2022 May 13;23(10). Epub 2022 May 13.

Department of Pharmacology, Toxicology and Clinical Pharmacology, Iuliu Hatieganu University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania.

There are limited neuroprotective strategies for various central nervous system conditions in which fast and sustained management is essential. Neuroprotection-based therapeutics have become an intensively researched topic in the neuroscience field, with multiple novel promising agents, from natural products to mesenchymal stem cells, homing peptides, and nanoparticles-mediated agents, all aiming to significantly provide neuroprotection in experimental and clinical studies. Dexmedetomidine (DEX), an α2 agonist commonly used as an anesthetic adjuvant for sedation and as an opioid-sparing medication, stands out in this context due to its well-established neuroprotective effects. Read More

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Chondroitin sulfate proteoglycans prevent immune cell phenotypic conversion and inflammation resolution via TLR4 in rodent models of spinal cord injury.

Nat Commun 2022 May 25;13(1):2933. Epub 2022 May 25.

King's College London, Regeneration Group, The Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, Guy's Campus, London Bridge, London, SE1 1UL, UK.

Chondroitin sulfate proteoglycans (CSPGs) act as potent inhibitors of axonal growth and neuroplasticity after spinal cord injury (SCI). Here we reveal that CSPGs also play a critical role in preventing inflammation resolution by blocking the conversion of pro-inflammatory immune cells to a pro-repair phenotype in rodent models of SCI. We demonstrate that enzymatic digestion of CSPG glycosaminoglycans enhances immune cell clearance and reduces pro-inflammatory protein and gene expression profiles at key resolution time points. Read More

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Mortality and Years of Life Lost due to Burn Injury Among Older Iranian People; a Cross-Sectional study.

Arch Acad Emerg Med 2022 27;10(1):e31. Epub 2022 Apr 27.

Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: The mortality of burn injury is a serious health problem among older people. The present study aimed to determine the epidemiological characteristics of burn mortality and Years of Life Lost (YLLs) among people aged ≥ 60.

Methods: The National and Subnational Burden of Disease (NASBOD) study includes population-based cross-sectional data from the death registration system of Iran and those recorded by the cemeteries of Tehran and Esfahan were used in this study. Read More

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Robot-assisted gait training in patients with Parkinson's disease: Implications for clinical practice. A systematic review.

NeuroRehabilitation 2022 May 9. Epub 2022 May 9.

Valduce Hospital "Villa Beretta" Rehabilitation Center, Costa Masnaga, Italy.

Background: Gait impairments are common disabling symptoms of Parkinson's disease (PD). Among the approaches for gait rehabilitation, interest in robotic devices has grown in recent years. However, the effectiveness compared to other interventions, the optimum amount of training, the type of device, and which patients might benefit most remains unclear. Read More

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Stool Management Followed by Surgical Debridement and Surgical Closure Combined With Negative Pressure Wound Therapy in the Treatment of Posterior Trunk Pressure Injury: A Retrospective Descriptive Study.

Wound Manag Prev 2022 04;68(4):26-33

Department of Burn and Plastic Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Background: Pressure injuries are a burden to patients and the health care system, and negative pressure wound therapy (NPWT) is a widely used treatment.

Purpose: This study sought to assess the effect of stool management followed by surgical debridement and surgical closure combined with NPWT in the treatment of posterior trunk pressure injuries.

Methods: A retrospective descriptive study was conducted in patients with stage 3 or 4 posterior trunk pressure injuries by reviewing electronic health records. Read More

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Expectations of a Health-Related Mobile Self-Management App Intervention Among Individuals With Spinal Cord Injury.

Top Spinal Cord Inj Rehabil 2022 12;28(2):205-215. Epub 2022 Apr 12.

International Collaboration on Repair Discoveries, Vancouver, Canada.

Background: Our research team developed a mobile application (app) to facilitate health-related self-management behaviors for secondary conditions among individuals with spinal cord injury (SCI). To facilitate mobile app adoption and ongoing use into the community, it is important to understand potential users' expectations and needs.

Objectives: The primary objective of this study was to explore user expectations of a mobile app intervention designed to facilitate self-management behavior among individuals with SCI. Read More

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Central Neuropathic Pain Syndromes: Current and Emerging Pharmacological Strategies.

CNS Drugs 2022 May 5;36(5):483-516. Epub 2022 May 5.

Department of Anesthesiology, Washington University School of Medicine, Campus Box 8054, St Louis, MO, 63110, USA.

Central neuropathic pain is caused by a disease or lesion of the brain or spinal cord. It is difficult to predict which patients will develop central pain syndromes after a central nervous system injury, but depending on the etiology, lifetime prevalence may be greater than 50%. The resulting pain is often highly distressing and difficult to treat, with no specific treatment guidelines currently available. Read More

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Adverse Impacts of Imposing International Economic Sanctions on Health.

Arch Iran Med 2022 03 1;25(3):182-190. Epub 2022 Mar 1.

Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: International economic sanctions (IES) influence a country's economic development and the overall welfare of a nation's population.

Methods: An electronic search of PubMed, Embase and Web of Science was conducted until July 31, 2019. Additionally, a list of references to related articles was reviewed. Read More

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Barriers and factors associated with the use of helmets by Motorcyclists: A scoping review.

Accid Anal Prev 2022 Jun 9;171:106667. Epub 2022 Apr 9.

Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran; Universal Scientific Education and Research Network (USERN), Tehran, Iran; Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran; Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran; Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran; Visiting Professor, Spine Program, University of Toronto, Toronto, Canada. Electronic address:

Road Traffic Injuries (RTIs) have imposed a great global burden on public health. Motorcyclists and pedestrians comprise the most significant proportion of this burden. Several studies have demonstrated a link between helmet wearing and a decline in the impact of RTIs in motorcyclists. Read More

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Identification of a circRNA-mediated comprehensive ceRNA network in spinal cord injury pathogenesis.

Exp Biol Med (Maywood) 2022 Jun 11;247(11):931-944. Epub 2022 Apr 11.

Basic Medical College, The Fourth Military Medical University, Xi'an 710032, China.

RNAs are closely associated with human diseases; however, immune-related genes (IRGs) and their potential regulatory networks in relation to spinal cord injury (SCI) are still poorly understood. Here, we investigated the key IRGs as well as the competing endogenous RNA (ceRNA) mechanisms that are associated with SCI pathogenesis based on microarray datasets and the use of a rat SCI model. Specifically, four independent SCI microarray datasets from Gene Expression Omnibus (GEO) database were analyzed and, thereafter, differentially expressed IRGs were annotated via Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. Read More

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Emerging Mechanisms and Targeted Therapy of Pyroptosis in Central Nervous System Trauma.

Front Cell Dev Biol 2022 25;10:832114. Epub 2022 Mar 25.

Department of Neurosurgery, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Cell death can occur in different modes, ferroptosis, pyroptosis, apoptosis, and necroptosis. Recent studies have shown that pyroptosis can be effectively regulated and that like necroptosis, pyroptosis has been regarded as a type of programmed cell death. The mechanism of its occurrence can be divided into canonical inflammasome-induced pyroptosis and noncanonical inflammasome-induced pyroptosis. Read More

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Neuroinflammation and apoptosis after surgery for a rat model of double-level cervical cord compression.

Neurochem Int 2022 07 6;157:105340. Epub 2022 Apr 6.

Spine Disease Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China. Electronic address:

Introduction: Cervical spondylotic myelopathy (CSM) is the most prevalent type of non-traumatic spinal cord injury. The pathological process of CSM is relatively complicated. Most of the chronic cervical cord compression animal models established using hydrophilic expanding polymer are single-segment compression, which was deviated from clinical practice with double-segment or multi-segment compression. Read More

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Effects of astrocytes and microglia on neuroinflammation after spinal cord injury and related immunomodulatory strategies.

Int Immunopharmacol 2022 Jul 6;108:108754. Epub 2022 Apr 6.

Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China; Department of Orthopedics, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China. Electronic address:

Spinal cord injury (SCI) is a catastrophic event which is still without adequate therapies. Neuroinflammation is the main pathogenesis of secondary damage post-SCI, leading to tissue loss and neurological dysfunction. Previous studies have shown that microglia and astrocytes are the major immune cells in the central nervous system (CNS) and play a crucial role in modulating neuroinflammatory responses. Read More

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Effects of Arm-Crank Exercise on Fitness and Health in Adults With Chronic Spinal Cord Injury: A Systematic Review.

Front Physiol 2022 17;13:831372. Epub 2022 Mar 17.

School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom.

Individuals with spinal cord injury (SCI) may benefit less from exercise training due to consequences of their injury, leading to lower cardiorespiratory fitness and higher risks of developing cardiovascular diseases. Arm-crank exercise (ACE) is the most common form of volitional aerobic exercise used by people with SCI outside a hospital. However, evidence regarding the specific effects of ACE alone on fitness and health in adults with SCI is currently lacking. Read More

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Expert-augmented automated machine learning optimizes hemodynamic predictors of spinal cord injury outcome.

PLoS One 2022 7;17(4):e0265254. Epub 2022 Apr 7.

Weill Institute for Neurosciences, Brain and Spinal Injury Center, University of California, San Francisco (UCSF), San Francisco, California, United States of America.

Artificial intelligence and machine learning (AI/ML) is becoming increasingly more accessible to biomedical researchers with significant potential to transform biomedicine through optimization of highly-accurate predictive models and enabling better understanding of disease biology. Automated machine learning (AutoML) in particular is positioned to democratize artificial intelligence (AI) by reducing the amount of human input and ML expertise needed. However, successful translation of AI/ML in biomedicine requires moving beyond optimizing only for prediction accuracy and towards establishing reproducible clinical and biological inferences. Read More

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Effect of Sirtuin-1 and Wnt/-Catenin Signaling Pathway in Rat Model of Spinal Cord Injury.

Comput Math Methods Med 2022 27;2022:1799607. Epub 2022 Mar 27.

Department of Orthopedics, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China.

Sirtuin-1 (SIRT1) has anti-inflammatory and antioxidant effects and has been reported to be involved in spinal cord injury (SCI). Wnt/-catenin signal has been shown to play a critical role in the pathogenesis of chronic diseases, and it participated in the recovery of nerve function after SCI. However, the specific link between them in SCI is unclear. Read More

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Mitochondrial-targeting antioxidant MitoQ modulates angiogenesis and promotes functional recovery after spinal cord injury.

Brain Res 2022 07 4;1786:147902. Epub 2022 Apr 4.

Department of Orthopedic Surgery, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200233, China; Institute of Microsurgery on Extremities, Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China. Electronic address:

Background: In traumatic spinal cord injury (SCI), secondary injuries, including cellular death, mitochondrial dysfunction, and vascular injury, have been considered as important causes of impaired functional recovery after SCI. Postinjury angiogenesis has been considered to be a potential strategy for SCI treatment. New-born vessels may play a key role in nerve regeneration, which indicates the importance of angiogenesis in nerve regeneration. Read More

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Photobiomodulation Attenuates Neurotoxic Polarization of Macrophages by Inhibiting the Notch1-HIF-1α/NF-κB Signalling Pathway in Mice With Spinal Cord Injury.

Front Immunol 2022 17;13:816952. Epub 2022 Mar 17.

Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Spinal cord injury (SCI) is a catastrophic disease with a complex pathogenesis that includes inflammation, oxidative stress, and glial scar formation. Macrophages are the main mediators of the inflammatory response and are distributed in the epicentre of the SCI. Macrophages have neurotoxic and neuroprotective phenotypes (also known as classically and alternatively activated macrophages or M1 and M2 macrophages) that are associated with pro- or anti- inflammatory gene expression. Read More

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Magnolol prevented brain injury through the modulation of Nrf2-dependent oxidative stress and apoptosis in PLP-induced mouse model of multiple sclerosis.

Naunyn Schmiedebergs Arch Pharmacol 2022 06 29;395(6):717-733. Epub 2022 Mar 29.

Pharmacological Sciences Research Lab, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

Multiple sclerosis (MS) is an immune-mediated chronic inflammatory demyelinating disease of the central nervous system (CNS). The aim of the current study was to investigate the effects of magnolol in an experimental autoimmune encephalomyelitis (EAE) model of MS in female mice. Magnolol (0. Read More

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Non-coding RNAs in the regulation of blood-brain barrier functions in central nervous system disorders.

Fluids Barriers CNS 2022 Mar 26;19(1):27. Epub 2022 Mar 26.

Department of Neurology, Pittsburgh Institute of Brain Disorders and Recovery, University of Pittsburgh School of Medicine, S514 BST, 200 Lothrop Street, Pittsburgh, PA, 15213, USA.

The blood-brain barrier (BBB) is an essential component of the neurovascular unit that controls the exchanges of various biological substances between the blood and the brain. BBB damage is a common feature of different central nervous systems (CNS) disorders and plays a vital role in the pathogenesis of the diseases. Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNA (lncRNAs), and circular RNAs (circRNAs), are important regulatory RNA molecules that are involved in almost all cellular processes in normal development and various diseases, including CNS diseases. Read More

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Ski Regulates the Inflammatory Response of Reactive Astrocytes Induced by Oxygen Glucose Deprivation/Reoxygenation (OGD/R) Through the NF-κB Pathway.

Neuroscience 2022 05 23;490:250-263. Epub 2022 Mar 23.

The Second Clinical Medical College of Lanzhou University, Lanzhou 730000, PR China; Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou 730000, PR China. Electronic address:

Spinal cord injury (SCI) is a common disease of the nervous system, including primary and secondary injuries. Neuronal inflammation after SCI is the most important pathological process of SCI and a chemical barrier to nerve function recovery after injury. Ski, an evolutionarily conserved functional transcriptional regulator protein, is upregulated in reactive astrocytes after SCI and regulates the biological characteristics of astrocytes. Read More

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