1,888 results match your criteria Spinal Cord Trauma and Related Diseases


Balance, gait, and falls in multiple sclerosis.

Handb Clin Neurol 2018 ;159:237-250

Department of Neurology, Oregon Health and Science University, Portland, OR, United States.

Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS) and the most widespread nontraumatic cause of disability in young adults around the world. MS occurs in people of all ages, races, and ethnicities. MS is characterized by clinical symptoms resulting from lesions in the brain, spinal cord, or optic nerves that can affect balance, gait, and fall risk. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/B97804446391650
Publisher Site
http://dx.doi.org/10.1016/B978-0-444-63916-5.00015-XDOI Listing
January 2018
5 Reads

Single-center experience with an inner branched arch endograft.

J Vasc Surg 2018 Nov 23. Epub 2018 Nov 23.

Department of Vascular Medicine, German Aortic Center, University Heart Center, Hamburg, Germany.

Objective: Whereas open repair is the "gold standard" for most aortic arch diseases, a subgroup of patients might benefit from an endovascular approach. The introduction of branched stent grafts with dedicated design to address the challenges of the ascending aorta and the aortic arch has opened an entirely new area of treatment for these patients. We investigated the early outcomes of branched thoracic endovascular aortic repair (b-TEVAR) in various types of disease of the aortic arch. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jvs.2018.07.076DOI Listing
November 2018
1 Read

Orthosilicic Acid Accelerates Bone Formation in Human Osteoblast-Like Cells Through the PI3K-Akt-mTOR Pathway.

Biol Trace Elem Res 2018 Nov 12. Epub 2018 Nov 12.

Department of Orthopedics, Qilu Hospital of Shandong University and Spine and Spinal Cord Disease Research Center, Shandong University, Jinan, Shandong, China.

Silicon is one of the essential trace elements in the human body; the deficiency of which may lead to bone diseases. Numerous animal experiments have shown that an appropriate increase in the intake of silicon is beneficial to enhancing bone density and toughness to prevent osteoporosis. However, the molecular mechanisms of the silicon-mediated osteogenesis process have not been sufficiently clarified. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12011-018-1574-9
Publisher Site
http://dx.doi.org/10.1007/s12011-018-1574-9DOI Listing
November 2018
13 Reads

Polycaprolactone electrospun fiber scaffold loaded with iPSCs-NSCs and ASCs as a novel tissue engineering scaffold for the treatment of spinal cord injury.

Int J Nanomedicine 2018 10;13:6265-6277. Epub 2018 Oct 10.

International Science and Technology Cooperation Base of Spinal Cord Injury, Department of Orthopedic Surgery, Tianjin Medical University General Hospital, Tianjin, People's Republic of China,

Background: Spinal cord injury (SCI) is a traumatic disease of the central nervous system, accompanied with high incidence and high disability rate. Tissue engineering scaffold can be used as therapeutic systems to provide effective repair for SCI.

Purpose: In this study, a novel tissue engineering scaffold has been synthesized in order to explore the effect of nerve repair on SCI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/IJN.S175914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186894PMC
December 2018

Postnatal neural crest stem cells from hair follicle interact with nerve tissue in vitro and in vivo.

Tissue Cell 2018 Oct 18;54:94-104. Epub 2018 Aug 18.

Koltzov Institute of Developmental Biology of the Russian Academy of Sciences, Vavilova 26, 119334, Moscow, Russian Federation; Pirogov Russian National Research Medical University, Ostrovitianova 1, 117997, Moscow, Russian Federation; Lomonosov Moscow State University, Leninskie Gory 1, Moscow, Russian Federation.

Neural crest stem cells that located in the postnatal hair follicle (HF-NCSC) are considered a promising tool for treatment of nervous system diseases and injuries. It is well known that HF-NCSC can be used in the spinal cord and sciatic nerve reparation but their ability to restore brain structures is poorly studied. In this article we are investigating the interaction between HF-NCSC and a nerve tissue (embryonic and adult). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00408166173041
Publisher Site
http://dx.doi.org/10.1016/j.tice.2018.08.005DOI Listing
October 2018
5 Reads

A population-based analysis of outcomes after repair of thoracic aortic emergencies in trauma.

J Surg Res 2018 Nov 29;231:352-360. Epub 2018 Jun 29.

Trauma Service, Scripps Mercy Hospital (MER-62), San Diego, California.

Background: Large-scale assessments of outcomes in thoracic endovascular repair (TEVAR) for thoracic aortic emergencies are lacking. We evaluated perioperative outcomes of TEVAR compared with open surgery among trauma patients in a large statewide database.

Materials And Methods: We evaluated the California Office of Statewide Health Planning and Development 2007-2014 patient discharge database. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00224804183038
Publisher Site
http://dx.doi.org/10.1016/j.jss.2018.06.003DOI Listing
November 2018
1 Read

Long Term Follow-Up Results of Spinal Concussion Cases: Definition of Late Injuries of the Spinal Cord.

Authors:
Ziya Asan

World Neurosurg 2018 Dec 25;120:e1325-e1330. Epub 2018 Sep 25.

Department of Neurosurgery, Faculty of Medicine, Ahi Evran University, Kirsehir, Turkey. Electronic address:

Objective: This study aims to evaluate the long-term clinical and radiologic findings of cases diagnosed with spinal concussion and to describe the spinal cord injuries that are detected in the later course.

Methods: Data obtained from 91 cases, who had been diagnosed with spinal concussion, were retrospectively evaluated. These were placed in 2 groups according to the type of trauma (axial forces or vertical forces). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wneu.2018.09.078DOI Listing
December 2018
3 Reads

Clinical and Radiologic Features of Osteoporotic Spine Fracture with Delayed Neurologic Compromises.

World Neurosurg 2018 Dec 19;120:e1295-e1300. Epub 2018 Sep 19.

Department of Orthopedic Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Objectives: Osteoporotic spine fractures (OSFs) with delayed neurologic compromises (NCs) have been increasingly reported. Although several studies have addressed that the pathologic mechanism of NC involves nonunion and segmental instability, the risk factors remain unclear. Therefore, the purpose of this study was to assess the radiologic and clinical features of OSFs with delayed NC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wneu.2018.09.056DOI Listing
December 2018
1 Read
2.420 Impact Factor

Towards rationally designed biomanufacturing of therapeutic extracellular vesicles: impact of the bioproduction microenvironment.

Biotechnol Adv 2018 Dec 12;36(8):2051-2059. Epub 2018 Sep 12.

Fischell Department of Bioengineering, University of Maryland, 3102 A. James Clark Hall, College Park, MD 20742, United States; Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, Baltimore, MD 21201, United States; Program in Molecular and Cell Biology, University of Maryland, College Park, MD 20742, United States. Electronic address:

Extracellular vesicles (EVs), including exosomes, microvesicles, and others, have emerged as potential therapeutics for a variety of applications. Pre-clinical reports of EV efficacy in treatment of non-healing wounds, myocardial infarction, osteoarthritis, traumatic brain injury, spinal cord injury, and many other injuries and diseases demonstrate the versatility of this nascent therapeutic modality. EVs have also been demonstrated to be effective in humans, and clinical trials are underway to further explore their potential. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07349750183015
Publisher Site
http://dx.doi.org/10.1016/j.biotechadv.2018.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250573PMC
December 2018
23 Reads

Changes of Spinal Edema and Expression of Aquaporin 4 in Methylprednisolone-treated Rats with Spinal Cord Injury.

Ann Clin Lab Sci 2018 Jul;48(4):453-459

Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun, China.

The aim of the current study was to investigate the impact of methylprednisolone (MP) on the expression of Aquaporin 4 (AQP4) and spinal edema in rats with acute spinal cord injury (ASCI). Sprague-Dawley (SD) Wistar rats were randomly divided into the following groups: control (C), sham operation (S), ASCI, and MP-treated. After the ASCI model was induced and prepared, 30 mg/kg MP was injected via the tail vein, on postoperative days 1, 3, and 7. Read More

View Article

Download full-text PDF

Source

Disc herniation caused by a viscoelastic nucleus after total lumbar disc replacement-a case report.

J Spine Surg 2018 Jun;4(2):478-482

Department of Neurosurgery, Trauma Center Murnau, Murnau, Germany.

Degenerative disc disease (DDD) is highly prevalent. If conservative treatment fails, spinal fusion procedures are commonly performed. Total disc replacement (TDR) might be a surgical option for a distinct subset of patients with DDD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/jss.2018.05.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046337PMC

Spotlight on postural control in patients with multiple sclerosis.

Degener Neurol Neuromuscul Dis 2018 3;8:25-34. Epub 2018 Apr 3.

Department of Neurology and Psychiatry, Sapienza University, Rome, Italy.

Multiple sclerosis (MS) is a disease that heavily affects postural control, predisposing patients to accidental falls and fall-related injuries, with a relevant burden on their families, health care systems and themselves. Clinical scales aimed to assess balance are easy to administer in daily clinical setting, but suffer from several limitations including their variable execution, subjective judgment in the scoring system, poor performance in identifying patients at higher risk of falls, and statistical concerns mainly related to distribution of their scores. Today we are able to objectively and reliably assess postural control not only with laboratory-grade standard force platform, but also with low-cost systems based on commercial devices that provide acceptable comparability to gold-standard equipment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/DNND.S135755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053902PMC
April 2018
7 Reads

Eugenol promotes functional recovery and alleviates inflammation, oxidative stress, and neural apoptosis in a rat model of spinal cord injury.

Restor Neurol Neurosci 2018 ;36(5):659-668

Department of Physical Medicine and Rehabilitation, The Second Hospital of Shandong University, Shandong University, Jinan, Shandong, PR China.

Background: Eugenol, a natural phenolic compound found in essential oils, shows a variety of remedial properties, while its effect on spinal cord injury (SCI) is still unknown.

Objective: To study the effects of Eugenol on SCI-related impairments in rats.

Methods: Rats received SCI or sham surgery were administered by oral gavage with Eugenol or physiological saline 6 hours following SCI and once a day for seven consecutive weeks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/RNN-180826DOI Listing
November 2018
1 Read

Effects of MicroRNA-494 on Astrocyte Proliferation and Synaptic Remodeling in the Spinal Cord of a Rat Model of Chronic Compressive Spinal Cord Injury by Regulating the Nogo/Ngr Signaling Pathway.

Cell Physiol Biochem 2018 23;48(3):919-933. Epub 2018 Jul 23.

Background/aims: Chronic compression of the spinal cord causes the loss of motor neurons in the anterior horn, but the precise and extensive mechanism for the loss is not completely determined. Therefore, this study aims to explore the role of microRNA-494 (miR-494) in the proliferation of astrocytes and in the synaptic remodeling in the spinal cord of a rat model of chronic spinal cord injury (SCI) by regulating the Nogo/NgR signaling pathway.

Methods: A rat model of chronic, compressive SCI was established, and the spinal cord state, blood supply changes, and astrocyte apoptosis were observed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000491959DOI Listing
September 2018
22 Reads

Astrocyte Neuroprotection and Dehydroepiandrosterone.

Vitam Horm 2018 19;108:175-203. Epub 2018 Feb 19.

Laboratório de Interação Neuro-Humoral, ICBS, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.

Dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) are the most abundant steroid hormones in the systemic circulation of humans. Due to their abundance and reduced production during aging, these hormones have been suggested to play a role in many aspects of health and have been used as drugs for a multiple range of therapeutic actions, including hormonal replacement and the improvement of aging-related diseases. In addition, several studies have shown that DHEA and DHEAS are neuroprotective under different experimental conditions, including models of ischemia, traumatic brain injury, spinal cord injury, glutamate excitotoxicity, and neurodegenerative diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/bs.vh.2018.01.004DOI Listing
November 2018
2 Reads

Evaluation of the Capabilities of Upper Extremity Test (CUE-T) in Children With Tetraplegia.

Top Spinal Cord Inj Rehabil 2018 ;24(3):239-251

Department of Occupational Therapy, Jefferson College of Health Professions, Jefferson (Philadelphia University + Thomas Jefferson University), Philadelphia, Pennsylvania.

The Capabilities of Upper Extremity Test (CUE-T) is a spinal cord injury (SCI)-specific instrument based on the CUE Questionnaire (CUE-Q). To evaluate the psychometric properties of CUE-T in children with cervical SCI and determine the lowest age appropriate for test administration. In this repeated measures multicenter study, 39 youths, mean age 12. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1310/sci2403-239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037325PMC
October 2018
11 Reads

Early Systemic Alterations in Severe Spinal Cord Injury: An Experimental Study on the Impact of Injury Level on Renal Function.

Spine (Phila Pa 1976) 2018 08;43(15):E885-E890

Proyecto Camina A.C., Cd. México, México.

Study Design: An experimental model of spinal cord injury (SCI) intended to characterize changes in renal function.

Objective: The aim of this study was to evaluate the possible influence of SCI level on renal function during spinal shock.

Summary Of Background Data: SCI triggers multiple systemic and metabolic alterations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/BRS.0000000000002578DOI Listing
August 2018
5 Reads

Tactile Sensor-Based Steering as a Substitute of the Attendant Joystick in Powered Wheelchairs.

IEEE Trans Neural Syst Rehabil Eng 2018 Jul;26(7):1381-1390

Attendant joysticks of powered wheelchairs are devices oriented to help caregivers. Diseases and disabilities such as dementia, spinal cord injuries or blindness make the user unable to drive the chair by his or her own. However, this device is not intuitive to use, especially for old people. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1109/TNSRE.2018.2838326DOI Listing

Implementation and initial outcomes of a spinal cord injury home care program at a large veterans affairs medical center.

J Spinal Cord Med 2018 Jul 2:1-8. Epub 2018 Jul 2.

a VA North Texas Health Care System , Dallas , Texas , USA.

Objectives: Describe an interdisciplinary spinal cord injury home care program (SCIHCP), sample demographics for the veteran participants, and initial impact of SCIHCP on health care utilization and mortality.

Design: Retrospective review.

Setting: SCIHCP of the Spinal Cord Injury Center, VA North Texas Health Care System (VANTHCS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10790268.2018.1485311DOI Listing
July 2018
6 Reads

[Precise application of Traditional Chinese Medicine in minimally-invasive techniques].

Authors:
Fu-Hui Dong

Zhongguo Gu Shang 2018 06;31(6):493-496

Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China;

The miminally-invasive techniques of traditional Chinese medicine(TCM) uses different types of acupuncture needles to treat diseased locations with special techniques. These techniques include different methods of insertion and closed incision (press cutting, sliding cutting, scrape cutting, etc.). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3969/j.issn.1003-0034.2018.06.001DOI Listing
June 2018
6 Reads

The role of mutated SOD1 gene in synaptic stripping and MHC class I expression following nerve axotomy in ALS murine model.

Eur J Histochem 2018 May 17;62(2):2904. Epub 2018 May 17.

University of Kentucky Medical Center.

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by motoneuron death. Several cellular pathways have been described to be involved in ALS pathogenesis; however, the involvement of presynaptic stripping and the related MHC class I molecules in mutant SOD1 motoneurons remains to be clarified. To this purpose, we here investigated, for the first time, the motoneurons behavior, di per seand after facial axonal injury, in terms of synaptic stripping and MHC class I expression in wild-type (Wt) mice and in a murine model of ALS, the SOD1(G93A) mice, at the presymptomatic and symptomatic stage of the disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4081/ejh.2018.2904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966710PMC

ATF2, but not ATF3, participates in the maintenance of nerve injury-induced tactile allodynia and thermal hyperalgesia.

Mol Pain 2018 Jan-Dec;14:1744806918787427. Epub 2018 Jun 19.

1 Neurobiology of Pain Laboratory, Departamento de Farmacobiología, Cinvestav, Mexico.

Transcription factors are proteins that modulate the transcriptional rate of target genes in the nucleus in response to extracellular or cytoplasmic signals. Activating transcription factors 2 (ATF2) and 3 (ATF3) respond to environmental signals and maintain cellular homeostasis. There is evidence that inflammation and nerve injury modulate ATF2 and ATF3 expression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1744806918787427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050803PMC
December 2018

Immune-evasive gene switch enables regulated delivery of chondroitinase after spinal cord injury.

Brain 2018 Jun 14. Epub 2018 Jun 14.

King's College London, Regeneration Group, The Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), Guy's Campus, London Bridge, London, SE1 1UL, UK.

Chondroitinase ABC is a promising preclinical therapy that promotes functional neuroplasticity after CNS injury by degrading extracellular matrix inhibitors. Efficient delivery of chondroitinase ABC to the injured mammalian spinal cord can be achieved by viral vector transgene delivery. This approach dramatically modulates injury pathology and restores sensorimotor functions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/awy158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061881PMC
June 2018
6 Reads

Lifelong Impacts of Moderate Prenatal Alcohol Exposure on Neuroimmune Function.

Front Immunol 2018 22;9:1107. Epub 2018 May 22.

Department of Neurosciences, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, United States.

alcohol exposure is emerging as a major risk factor for lifelong aberrant neuroimmune function. Fetal alcohol spectrum disorder encompasses a range of behavioral and physiological sequelae that may occur throughout life and includes cognitive developmental disabilities as well as disease susceptibility related to aberrant immune and neuroimmune actions. Emerging data from clinical studies and findings from animal models support that of fetal alcohol exposure may reprogram the developing central nervous system leading to altered neuroimmune and neuroglial signaling during adulthood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2018.01107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992426PMC

Personality, High-Risk Behaviors, and Elevated Risk of Unintentional Deaths Related to Drug Poisoning Among Individuals With Spinal Cord Injury.

Arch Phys Med Rehabil 2018 Oct 13;99(10):1941-1948. Epub 2018 Jun 13.

College of Health Professions, Medical University of South Carolina, Charleston, SC.

Objective: To identify risk and protective factors for unintentional death related to drug poisoning from prescription medications, including opioid-related deaths, and death due to all other causes among participants with spinal cord injury (SCI).

Design: Prospective cohort study.

Setting: Large specialty hospital in the southeastern United States. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00039993183036
Publisher Site
http://dx.doi.org/10.1016/j.apmr.2018.05.013DOI Listing
October 2018
14 Reads

FNDC5 expression in Purkinje neurons of adult male rats with acute spinal cord injury following treatment with methylprednisolone.

Neuropeptides 2018 Aug 7;70:16-25. Epub 2018 May 7.

Department of Medical Basic Sciences, University of social Welfare and Rehabilitation Sciences, Tehran, Iran.

Spinal cord injury (SCI) is a serious and complex medical condition that can happen to anyone. At present, therapy mainly focuses on rehabilitation and pharmacological treatment, such as methylprednisolone (MP). Supra-spinal changes in certain structures, such as the cerebellum, that receive many afferents from the spinal cord might be one reason for unsuccessful therapeutic outcomes. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01434179183000
Publisher Site
http://dx.doi.org/10.1016/j.npep.2018.05.002DOI Listing
August 2018
24 Reads

Epidemiological Trends of Traumatic Brain and Spinal Cord Injury in Puerto Rico from November 10th, 2006, through May 24th, 2011.

P R Health Sci J 2018 Jun;37(2):67-77

Auxiliary Researcher III, Department of Surgery, University of Puerto Rico Medical Sciences Campus, San Juan, PR.

Objective: According to the Centers for Disease Control and Prevention (CDC), injury to the central nervous system (CNS) continues to be a leading cause of injury-related morbidity and mortality in the US today.

Methods: A prospective cohort study was performed to determine the incidence of all traumatic CNS injuries. Descriptive variables were presented as frequencies and percentages. Read More

View Article

Download full-text PDF

Source
June 2018
14 Reads

The dosage and administration of long-term intrathecal baclofen therapy for severe spasticity of spinal origin.

Spinal Cord 2018 Oct 12;56(10):996-999. Epub 2018 Jun 12.

Department of Orthopaedic Surgery, Spinal Injuries Center, Fukuoka, Japan.

Study Design: Retrospective chart audit.

Objective: To indicate the appropriate baclofen dosage to control severe spasticity of spinal origin and to develop the optimal administration protocol for long-term intrathecal baclofen (ITB) therapy.

Setting: Department of Orthopaedic Surgery, Spinal Injuries Center, Japan. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41393-018-0153-4DOI Listing
October 2018
1 Read

T-cell infiltration into the perilesional cortex is long-lasting and associates with poor somatomotor recovery after experimental traumatic brain injury.

Restor Neurol Neurosci 2018 ;36(4):485-501

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland.

Background: T-lymphocyte (T-cell) invasion into the brain parenchyma is a major consequence of traumatic brain injury (TBI). However, the role of T-cells in the post-TBI functional outcome and secondary inflammatory processes is unknown. We explored the dynamics of T-cell infiltration into the cortex after TBI to establish whether the infiltration relates to post-injury functional impairment/recovery and progression of the secondary injury. Read More

View Article

Download full-text PDF

Source
http://www.medra.org/servlet/aliasResolver?alias=iospress&am
Publisher Site
http://dx.doi.org/10.3233/RNN-170811DOI Listing
October 2018
18 Reads

Cell Adhesion Molecule Close Homolog of L1 (CHL1) Guides the Regrowth of Regenerating Motor Axons and Regulates Synaptic Coverage of Motor Neurons.

Front Mol Neurosci 2018 24;11:174. Epub 2018 May 24.

Department of Cell Biology and Neuroscience, W. M. Keck Center for Collaborative Neuroscience, Rutgers University, Piscataway, NJ, United States.

The close homolog of L1 (CHL1) is a cell adhesion molecule involved in regulation of neuronal differentiation and survival, neurite outgrowth and axon guidance during development. In the mature nervous system, CHL1 regulates synaptic activity and plasticity. The aim of the present study was to evaluate the influence of CHL1 on peripheral nerve regeneration after trauma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnmol.2018.00174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976800PMC

The Top 50 Most-Cited Articles on Cervical Spondylotic Myelopathy.

World Neurosurg 2018 Aug 2;116:e1168-e1180. Epub 2018 Jun 2.

Department of Orthopaedics, Ohio State University, Columbus, Ohio, USA. Electronic address:

Background: Cervical spondylotic myelopathy (CSM) occurs due to chronic degenerative changes in the cervical spine causing compression of the spinal cord. CSM has been studied for decades, and numerous articles have been published on the topic. We sought to identify the top 50 most-cited articles on CSM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wneu.2018.05.191DOI Listing
August 2018
1 Read

Acrolein Contributes to the Neuropathic Pain and Neuron Damage after Ischemic-Reperfusion Spinal Cord Injury.

Neuroscience 2018 Aug 29;384:120-130. Epub 2018 May 29.

Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA. Electronic address:

Besides physical insult, spinal cord injury (SCI) can also result from transient ischemia, such as ischemia-reperfusion SCI (I/R SCI) as a postoperative complication. Increasing evidence has suggested that oxidative stress and related reactive aldehyde species are key contributors to cellular injury after SCI. Previous work in spinal cord contusion injury has demonstrated that acrolein, both a key product and an instigator of oxidative stress, contributes to post-traumatic hyperalgesia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuroscience.2018.05.029DOI Listing

Detecting malnutrition risk and obesity after spinal cord injury: a quality improvement project and systematic review.

Eur J Clin Nutr 2018 Nov 30;72(11):1555-1560. Epub 2018 May 30.

National Spinal Injuries Centre, Stoke Mandeville Hospital, Aylesbury, UK.

Background/objectives: Malnutrition and overweight are a major concern after spinal cord injury (SCI). There is limited information available for prevalence of malnutrition, overweight and nutrition screening compliance. The aim of this study is to (1) determine whether the quality improvement initiative is successful in improving nutrition screening and to (2) systematic review the literature on prevalence of malnutrition and overweight after SCI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41430-018-0194-yDOI Listing
November 2018
4 Reads

The natural course of passive tenodesis grip in individuals with spinal cord injury with preserved wrist extension power but paralyzed fingers and thumbs.

Spinal Cord 2018 09 22;56(9):900-906. Epub 2018 May 22.

Department of Rehabilitation Medicine, Seoul National University Hospital, Seoul, South Korea.

Study Design: Cross-sectional.

Objectives: To investigate the natural course of passive tenodesis grip in individuals with spinal cord injury (SCI) with no experience of tenodesis splint application and the related factors for success of the grip.

Setting: Community-dwelling persons with chronic SCI in South Korea. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41393-018-0137-4DOI Listing
September 2018
11 Reads

Acute intermittent hypoxia and rehabilitative training following cervical spinal injury alters neuronal hypoxia- and plasticity-associated protein expression.

PLoS One 2018 18;13(5):e0197486. Epub 2018 May 18.

Department of Biomedical Sciences, WCVM, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

One of the most promising approaches to improve recovery after spinal cord injury (SCI) is the augmentation of spontaneously occurring plasticity in uninjured neural pathways. Acute intermittent hypoxia (AIH, brief exposures to reduced O2 levels alternating with normal O2 levels) initiates plasticity in respiratory systems and has been shown to improve recovery in respiratory and non-respiratory spinal systems after SCI in experimental animals and humans. Although the mechanism by which AIH elicits its effects after SCI are not well understood, AIH is known to alter protein expression in spinal neurons in uninjured animals. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197486PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959066PMC
November 2018
3.230 Impact Factor

The impact of tackle football injuries on the American healthcare system with a neurological focus.

PLoS One 2018 7;13(5):e0195827. Epub 2018 May 7.

Department of Neurosurgery, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America.

Background: Recent interest in the study of concussion and other neurological injuries has heightened awareness of the medical implications of American tackle football injuries amongst the public.

Objective: Using the National Emergency Department Sample (NEDS) and the National Inpatient Sample (NIS), the largest publicly available all-payer emergency department and inpatient healthcare databases in the United States, we sought to describe the impact of tackle football injuries on the American healthcare system by delineating injuries, specifically neurological in nature, suffered as a consequence of tackle football between 2010 and 2013.

Methods: The NEDS and NIS databases were queried to collect data on all patients presented to the emergency department (ED) and/or were admitted to hospitals with an ICD code for injuries related to American tackle football between the years 2010 and 2013. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0195827PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937786PMC
July 2018
1 Read

Is Delayed Surgery After Unsuccessful Conservative Treatment Beneficial for Spinal Cord Injury Following Whiplash? A Retrospective Study in Elderly Patients.

Med Sci Monit 2018 May 5;24:2818-2824. Epub 2018 May 5.

Department of Orthopedic Surgery, The First Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China (mainland).

BACKGROUND The aim of this study was to investigate the clinical outcomes of early and delayed surgery in cervical spinal cord injury following whiplash in elderly patients. MATERIAL AND METHODS Our retrospective review identified elderly patients (≥65 years old) with spinal cord injury following whiplash injury from 2006 to 2015. The neck disability index (NDI), modify Japanese Orthopedics Association (mJOA) score, and visual analogue scale (VAS) score were used to evaluate clinical outcomes preoperatively and during follow-up. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.907091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956973PMC
May 2018
1 Read

A scoping review on health economics in neurosurgery for acute spine trauma.

Neurosurg Focus 2018 May;44(5):E15

Lyndhurst Centre, Toronto Rehabilitation Institute, University Health Network; and.

OBJECTIVE Acute spine trauma (AST) has a relatively low incidence, but it often results in substantial individual impairments and societal economic burden resulting from the associated disability. Given the key role of neurosurgeons in the decision-making regarding operative management of individuals with AST, the authors performed a systematic search with scoping synthesis of relevant literature to review current knowledge regarding the economic burden of AST. METHODS This systematic review with scoping synthesis included original articles reporting cost-effectiveness, cost-utility, cost-benefit, cost-minimization, cost-comparison, and economic analyses related to surgical management of AST, whereby AST is defined as trauma to the spine that may result in spinal cord injury with motor, sensory, and/or autonomic impairment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3171/2018.2.FOCUS17778DOI Listing
May 2018
1 Read

Estrogen alleviates neuropathic pain induced after spinal cord injury by inhibiting microglia and astrocyte activation.

Biochim Biophys Acta Mol Basis Dis 2018 Jul 16;1864(7):2472-2480. Epub 2018 Apr 16.

Age-Related and Brain Diseases Research Center, Kyung Hee University, Seoul 02447, Republic of Korea; Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea; KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul 130-701, Republic of Korea. Electronic address:

Neuropathic pain after spinal cord injury (SCI) is developed in about 80% of SCI patients and there is no efficient therapeutic drug to alleviate SCI-induced neuropathic pain. Here we examined the effect of estrogen on SCI-induced neuropathic pain at below-level and its effect on neuroinflammation as underlying mechanisms. Neuropathic pain is developed at late phase after SCI and a single dose of 17β-estradiol (100, 300 μg/kg) were administered to rats with neuropathic pain after SCI through intravenous injection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbadis.2018.04.006DOI Listing
July 2018
3 Reads

Acute and Chronic Musculoskeletal Injury in Para Sport: A Critical Review.

Phys Med Rehabil Clin N Am 2018 05;29(2):205-243

Centre for Sport and Exercise Science and Medicine (SESAME), School of Sport and Service Management, University of Brighton, Mithras House Lewes Road, Brighton BN2 4AT, UK.

Sport-related injury patterns among Para athletes have been described with increasing frequency. This review summarizes musculoskeletal injuries in Para athletes. Seated Para athletes sustain upper extremity injuries more commonly; ambulant Para athletes frequently sustain lower extremity injuries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pmr.2018.01.014DOI Listing
May 2018
1 Read

Age-specific characterization of spinal cord injuries over a 19-year period at a Japanese rehabilitation center.

PLoS One 2018 29;13(3):e0195120. Epub 2018 Mar 29.

Department of Physical Medicine and Rehabilitation, Hyogo Rehabilitation Center, Akebono-cho, Nishi-ku, Kobe, Japan.

Regional demographics of spinal cord injuries (SCIs) are fundamental to identifying and implementing appropriate preventive measures. The current study was conducted as a longitudinal analysis of all patients with SCIs admitted to the Hyogo Rehabilitation Center over a 19-year period. The sex and age of the patient, time and nature of injury (i. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0195120PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875854PMC
July 2018
3.234 Impact Factor

Anti-Apoptotic Mechanisms of Acupuncture in Neurological Diseases: A Review.

Am J Chin Med 2018 29;46(3):515-535. Epub 2018 Mar 29.

1 Department of Acupuncture, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China.

Apoptosis, known as programmed cell death, plays a significant role in the pathogenesis of neurological diseases. Most of these diseases can be obviously alleviated by means of acupuncture treatment. Current research studies have shown that the efficacy of acupuncture to these medical conditions is closely associated with the anti-apoptotic potentials. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X1850026XDOI Listing
July 2018
1 Read

AIS scores in spine and spinal cord trauma: Epidemiological considerations.

Traffic Inj Prev 2018 02;19(sup1):S169-S173

a Department of Neurosurgery , Medical College of Wisconsin , Milwaukee , Wisconsin.

Background: The Abbreviated Injury Scale (AIS) is an internationally accepted coding system created by the Association for the Advancement of Automotive Medicine, utilized to code traumatic injuries as a function of severity, the latter often defined as mortality risk. Periodic reassessment of that risk is prudent, in light of advances in health care and relationship of nonanatomic factors to death.

Objective: The objective of this study was to reevaluate the risk of death associated with spine fractures with and without neurologic deficit, age factors associated with it, and the impact of hospital coding on the accuracy of these efforts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15389588.2017.1410144DOI Listing
February 2018
3 Reads
1.290 Impact Factor

Economic burden of skeletal-related events in patients with multiple myeloma: analysis of US commercial claims database.

J Med Econ 2018 Jun 12;21(6):622-628. Epub 2018 Apr 12.

b IQVIA , Plymouth Meeting, PA , NC , USA.

Aims: To estimate incremental healthcare resource utilization (HRU) and costs associated with skeletal-related events (SREs) secondary to multiple myeloma (MM), and HRU and cost differences in patients with one vs multiple SREs.

Methods: Adults with MM diagnosis between January 1, 2010-December 31, 2014, with benefits coverage ≥12 months pre- and ≥6 months post-diagnosis were followed to last coverage date or December 31, 2015, excluding patients with prior anti-myeloma treatment or cancers. SREs were identified by diagnosis or procedure codes (pathological fracture, spinal cord compression, radiation, or surgery to the bone). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/13696998.2018.1457531DOI Listing
June 2018
4 Reads

Plasma adiponectin levels are correlated with body composition, metabolic profiles, and mitochondrial markers in individuals with chronic spinal cord injury.

Spinal Cord 2018 09 20;56(9):863-872. Epub 2018 Mar 20.

Spinal Cord Injury and Disorders, Hunter Holmes McGuire VA Medical Center, Richmond, VA, USA.

Study Design: Cross-sectional design.

Objectives: This study examined the relationships between circulating adiponectin levels, body composition, metabolic profile, and measures of skeletal muscle mitochondrial enzyme activity and biogenesis.

Settings: Clinical Research in a Medical Center. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41393-018-0089-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129201PMC
September 2018
10 Reads

Freezing of gait: Promising avenues for future treatment.

Parkinsonism Relat Disord 2018 Jul 12;52:7-16. Epub 2018 Mar 12.

Parkinson's Disease Research Clinic, Brain and Mind Centre, The University of Sydney, NSW, Australia. Electronic address:

Freezing of gait is a devastating symptom of Parkinson's disease and other forms of parkinsonism. It poses a major burden on both patients and their families, as freezing often leads to falls, fall-related injuries and a loss of independence. Treating freezing of gait is difficult for a variety of reasons: it has a paroxysmal and unpredictable nature; a multifaceted pathophysiology, with an interplay between motor elements (disturbed stepping mechanisms) and non-motor elements (cognitive decline, anxiety); and a complex (and likely heterogeneous) underlying neural substrate, involving multiple failing neural networks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.parkreldis.2018.03.009DOI Listing

No laughing matter: subacute degeneration of the spinal cord due to nitrous oxide inhalation.

J Neurol 2018 May 3;265(5):1089-1095. Epub 2018 Mar 3.

The Royal London Hospital, Emergency Care and Acute Medicine Clinical Academic Group, Neuroscience, Barts Health NHS Trust, London, UK.

Background: Whilst the dangers of 'legal highs' have been widely publicised in the media, very few cases of the neurological syndrome associated with the inhalation of nitrous oxide (NO) have been reported. Here we set out to raise awareness of subacute degeneration of the spinal cord arising from recreational NO use so that formal surveillance programs and public health interventions can be designed.

Methods: Case series documenting the clinical and investigational features of ten consecutive cases of subacute degeneration of the spinal cord presenting to a hospital with a tertiary neurosciences service in East London. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00415-018-8801-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937900PMC
May 2018
2 Reads

Characterization and comparison of rat monosodium iodoacetate and medial meniscal tear models of osteoarthritic pain.

J Orthop Res 2018 Feb 11. Epub 2018 Feb 11.

Neuroscience Discovery, Research and Development, AbbVie, 60064 North Chicago, Illinois.

Osteoarthritis (OA) is a degenerative form of arthritis that can result in loss of joint function and chronic pain. The pathological pain state that develops with OA disease involves plastic changes in the peripheral and central nervous systems, however, the cellular mechanisms underlying OA are not fully understood. We characterized the medial meniscal tear (MMT) surgical model and the intra-articular injection of monosodium iodoacetate (MIA) chemical model of OA in rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jor.23869DOI Listing
February 2018
5 Reads

Implantation of a Matrigel-loaded agarose scaffold promotes functional regeneration of axons after spinal cord injury in rat.

Biochem Biophys Res Commun 2018 02 1;496(3):785-791. Epub 2018 Feb 1.

Biomedical Research Institute, Korea Institute of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul, 02791, Republic of Korea; Division of Bio-Medical Science &Technology, KIST School, Korea University of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul, 02791, Republic of Korea. Electronic address:

An agarose scaffold can be useful for supporting and guiding injured axons after spinal cord injury (SCI), but the electrophysiological signal of regenerated axon in scaffolds has not yet been determined. The current study investigated whether a Matrigel-loaded agarose scaffold would enhance the regeneration of axons after SCI. Moreover, the functional connectivity of regenerated axons within the channels of the scaffold was evaluated by directly recording motor evoked potentials. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2018.01.157DOI Listing
February 2018
6 Reads

Operation of a P300-based brain-computer interface in patients with Duchenne muscular dystrophy.

Sci Rep 2018 01 29;8(1):1753. Epub 2018 Jan 29.

Systems Neuroscience Section, Department of Rehabilitation for Brain Functions, Research Institute of National Rehabilitation Center for Persons with Disabilities, Tokorozawa, Saitama, 359-8555, Japan.

A brain-computer interface (BCI) or brain-machine interface is a technology that enables the control of a computer and other external devices using signals from the brain. This technology has been tested in paralysed patients, such as those with cervical spinal cord injuries or amyotrophic lateral sclerosis, but it has not been tested systematically in Duchenne muscular dystrophy (DMD), which is a severe type of muscular dystrophy due to the loss of dystrophin and is often accompanied by progressive muscle weakness and wasting. Here, we investigated the efficacy of a P300-based BCI for patients with DMD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-20125-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788861PMC
January 2018
3 Reads