1,909 results match your criteria Spinal Cord Trauma and Related Diseases


Comparison of All-Cause and Cause-Specific Mortality of Persons with Traumatic Spinal Cord Injuries to the General Swiss Population: Results from a National Cohort Study.

Neuroepidemiology 2019 Feb 14;52(3-4):205-213. Epub 2019 Feb 14.

Swiss Paraplegic Research, Nottwil, Switzerland.

Background: Traumatic spinal cord injuries (TSCI) are a neurological condition associated with reduced well-being, increased morbidity and reductions in life expectancy. Estimates of all-cause and cause-specific mortality can aid in identifying targets for prevention and management of contributors for premature mortality.

Objectives: To compare all-cause and cause-specific rates of mortality to that of the Swiss general population; to identify differentials in risk of cause-specific mortality according to lesion characteristics. Read More

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http://dx.doi.org/10.1159/000496976DOI Listing
February 2019

A review and evaluation of patient-reported outcome measures for spasticity in persons with spinal cord damage: Recommendations from the Ability Network - an international initiative.

J Spinal Cord Med 2019 Feb 13:1-11. Epub 2019 Feb 13.

e Division of Physiatry, Division of Medicine , University of Toronto , Toronto , Canada.

Context: Patient-reported outcome measures (PROMs) are valuable for capturing the impact of spasticity on health-related quality of life (HRQoL) in persons with spinal cord damage (SCD) and evaluating the efficacy of interventions.

Objective: To provide practical guidance for measuring HRQoL in persons with spasticity following SCD.

Methods: Literature reviews identified measures of HRQoL and caregiver burden, utilized in studies addressing spasticity in SCD. Read More

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http://dx.doi.org/10.1080/10790268.2019.1575533DOI Listing
February 2019
1 Read

The Genomic Health of Human Pluripotent Stem Cells: Genomic Instability and the Consequences on Nuclear Organization.

Front Genet 2018 21;9:623. Epub 2019 Jan 21.

Laboratory of Nuclear and Genomic Health, Division of Biosciences, Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, United Kingdom.

Human pluripotent stem cells (hPSCs) are increasingly used for cell-based regenerative therapies worldwide, with embryonic and induced pluripotent stem cells as potential treatments for debilitating and chronic conditions, such as age-related macular degeneration, Parkinson's disease, spinal cord injuries, and type 1 diabetes. However, with the level of genomic anomalies stem cells generate in culture, their safety may be in question. Specifically, hPSCs frequently acquire chromosomal abnormalities, often with gains or losses of whole chromosomes. Read More

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http://dx.doi.org/10.3389/fgene.2018.00623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348275PMC
January 2019

Circular RNA Expression Alteration and Bioinformatics Analysis in Rats After Traumatic Spinal Cord Injury.

Front Mol Neurosci 2018 14;11:497. Epub 2019 Jan 14.

School of Rehabilitation Medicine, Capital Medical University, Beijing, China.

Spinal cord injury (SCI) is mostly caused by trauma. As primary mechanical injury is unavoidable in SCI, a focus on the pathophysiology and underlying molecular mechanisms of SCI-induced secondary injury is necessary to develop promising treatments for SCI patients. Circular RNAs (circRNAs) are associated with various diseases. Read More

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http://dx.doi.org/10.3389/fnmol.2018.00497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339904PMC
January 2019

Bisperoxovanadium mediates neuronal protection through inhibition of PTEN and activation of PI3K/AKT-mTOR signaling following traumatic spinal injuries.

J Neurotrauma 2019 Jan 23. Epub 2019 Jan 23.

Indiana University, Neurological Surgery , 950 E. Walnut St., R2-427 , Indianapolis, Indiana, United States , 46202.

Though mechanisms involved in progression of cell death in spinal cord injury (SCI) have been extensively studied, few are clear targets for translation to clinical application. One of the best-understood mechanisms of cell survival in SCI is phosphatidylinositol-3-kinase (PI3K)/Akt and associated downstream signaling. Clear therapeutic efficacy of a phosphatase and tensin homologue (PTEN) inhibitor called bisperoxovanadium (bpV) has been shown in SCI, traumatic brain injury, stroke, and other neurological disease models in both neuroprotection and functional recovery. Read More

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http://dx.doi.org/10.1089/neu.2018.6294DOI Listing
January 2019

Protocatechuic acid improves functional recovery after spinal cord injury by attenuating blood-spinal cord barrier disruption and hemorrhage in rats.

Neurochem Int 2019 Mar 18;124:181-192. Epub 2019 Jan 18.

Age-Related and Brain Diseases Research Center, Kyung Hee University, Seoul, 02447, Republic of Korea; KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul, 02447, Republic of Korea; Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul, 02447, Republic of Korea. Electronic address:

After spinal cord injury (SCI), blood-spinal cord barrier (BSCB) disruption and hemorrhage lead to blood cell infiltration and progressive secondary injuries including inflammation. Inflammatory response is one of the major events resulting in apoptosis, scar formation and neuronal dysfunction after SCI. Here, we investigated whether protocatechuic acid (PCA), a natural phenolic compound, would attenuate BSCB disruption and hemorrhage, leading to functional improvement after SCI. Read More

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http://dx.doi.org/10.1016/j.neuint.2019.01.013DOI Listing
March 2019
3 Reads

GPR17 receptor modulators and their therapeutic implications: review of recent patents.

Expert Opin Ther Pat 2019 Feb 24;29(2):85-95. Epub 2019 Jan 24.

a School of Pharmacy, Medicinal Chemistry Unit , University of Camerino , Camerino , Italy.

Introduction: The GPR17 receptor, phylogenetically related to both purinergic P2Y and CysLT receptors, is mainly expressed in the CNS and, in general, in organs that can typically undergo ischemic damage. This receptor is involved in various pathologies including stroke, brain and spinal cord trauma, multiple sclerosis and in all diseases characterized by neuronal and myelin dysfunction. Therefore, there is a strong needed to identify molecules capable of binding specifically to GPR17 receptors. Read More

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http://dx.doi.org/10.1080/13543776.2019.1568990DOI Listing
February 2019
2 Reads

An Immune-CNS Axis Activates Remote Hippocampal Stem Cells Following Spinal Transection Injury.

Front Mol Neurosci 2018 11;11:443. Epub 2018 Dec 11.

Molecular Neurobiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

External stimuli such as injury, learning, or stress influence the production of neurons by neural stem cells (NSCs) in the adult mammalian brain. These external stimuli directly impact stem cell activity by influencing areas directly connected or in close proximity to the neurogenic niches of the adult brain. However, very little is known on how distant injuries affect NSC activation state. Read More

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https://www.frontiersin.org/article/10.3389/fnmol.2018.00443
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http://dx.doi.org/10.3389/fnmol.2018.00443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299844PMC
December 2018
4 Reads

Individual variations of the human corticospinal tract and its hand-related motor fibers using diffusion MRI tractography.

Brain Imaging Behav 2019 Jan 8. Epub 2019 Jan 8.

Department of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

The corticospinal tract (CST) is one of the most well studied tracts in human neuroanatomy. Its clinical significance can be demonstrated in many notable traumatic conditions and diseases such as stroke, spinal cord injury (SCI) or amyotrophic lateral sclerosis (ALS). With the advent of diffusion MRI and tractography the computational representation of the human CST in a 3D model became available. Read More

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http://link.springer.com/10.1007/s11682-018-0006-y
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http://dx.doi.org/10.1007/s11682-018-0006-yDOI Listing
January 2019
2 Reads

Pre-collision Medical Diagnoses Predict Chronic Neck Pain Following Acute Whiplash-trauma.

Clin J Pain 2018 Dec 26. Epub 2018 Dec 26.

The Research Clinic for Functional Disorders and Psychosomatics, Aarhus University Hospital, Noerrebrogade 44, 8000 Aarhus C, Denmark.

Objectives: The reason why some individuals develop chronic symptoms, whiplash-associated disorder, following whiplash trauma is poorly understood. We explored whether pre-collision pain-related diagnoses, medically unexplained symptoms and psychiatric diagnoses are related to whiplash-associated disorder.

Methods: A cohort of 719 individuals exposed to whiplash trauma and subsequently experiencing symptoms within 72 hours (whiplash-exposed cohort) and 3595 matched controls were included in this observational prospective study. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000683DOI Listing
December 2018
5 Reads
2.527 Impact Factor

The IASP classification of chronic pain for ICD-11: chronic neuropathic pain.

Pain 2019 Jan;160(1):53-59

Department of Neurophysiology, CBTM, Medical Faculty Mannheim of Heidelberg University, Mannheim, Germany.

The upcoming 11th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD) of the World Health Organization (WHO) offers a unique opportunity to improve the representation of painful disorders. For this purpose, the International Association for the Study of Pain (IASP) has convened an interdisciplinary task force of pain specialists. Here, we present the case for a reclassification of nervous system lesions or diseases associated with persistent or recurrent pain for ≥3 months. Read More

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http://Insights.ovid.com/crossref?an=00006396-201901000-0000
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http://dx.doi.org/10.1097/j.pain.0000000000001365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310153PMC
January 2019
12 Reads
5.213 Impact Factor

Rapid and robust restoration of breathing long after spinal cord injury.

Nat Commun 2018 11 27;9(1):4843. Epub 2018 Nov 27.

Department of Neurosciences, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.

There exists an abundance of barriers that hinder functional recovery following spinal cord injury, especially at chronic stages. Here, we examine the rescue of breathing up to 1.5 years following cervical hemisection in the rat. Read More

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http://www.nature.com/articles/s41467-018-06937-0
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http://dx.doi.org/10.1038/s41467-018-06937-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258702PMC
November 2018
9 Reads

Balance, gait, and falls in multiple sclerosis.

Handb Clin Neurol 2018 ;159:237-250

Department of Neurology, Oregon Health and Science University, Portland, OR, United States.

Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS) and the most widespread nontraumatic cause of disability in young adults around the world. MS occurs in people of all ages, races, and ethnicities. MS is characterized by clinical symptoms resulting from lesions in the brain, spinal cord, or optic nerves that can affect balance, gait, and fall risk. Read More

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https://linkinghub.elsevier.com/retrieve/pii/B97804446391650
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http://dx.doi.org/10.1016/B978-0-444-63916-5.00015-XDOI Listing
January 2018
11 Reads

Single-center experience with an inner branched arch endograft.

J Vasc Surg 2018 Nov 23. Epub 2018 Nov 23.

Department of Vascular Medicine, German Aortic Center, University Heart Center, Hamburg, Germany.

Objective: Whereas open repair is the "gold standard" for most aortic arch diseases, a subgroup of patients might benefit from an endovascular approach. The introduction of branched stent grafts with dedicated design to address the challenges of the ascending aorta and the aortic arch has opened an entirely new area of treatment for these patients. We investigated the early outcomes of branched thoracic endovascular aortic repair (b-TEVAR) in various types of disease of the aortic arch. Read More

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http://dx.doi.org/10.1016/j.jvs.2018.07.076DOI Listing
November 2018
1 Read

Orthosilicic Acid Accelerates Bone Formation in Human Osteoblast-Like Cells Through the PI3K-Akt-mTOR Pathway.

Biol Trace Elem Res 2018 Nov 12. Epub 2018 Nov 12.

Department of Orthopedics, Qilu Hospital of Shandong University and Spine and Spinal Cord Disease Research Center, Shandong University, Jinan, Shandong, China.

Silicon is one of the essential trace elements in the human body; the deficiency of which may lead to bone diseases. Numerous animal experiments have shown that an appropriate increase in the intake of silicon is beneficial to enhancing bone density and toughness to prevent osteoporosis. However, the molecular mechanisms of the silicon-mediated osteogenesis process have not been sufficiently clarified. Read More

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http://link.springer.com/10.1007/s12011-018-1574-9
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http://dx.doi.org/10.1007/s12011-018-1574-9DOI Listing
November 2018
18 Reads

Polycaprolactone electrospun fiber scaffold loaded with iPSCs-NSCs and ASCs as a novel tissue engineering scaffold for the treatment of spinal cord injury.

Int J Nanomedicine 2018 10;13:6265-6277. Epub 2018 Oct 10.

International Science and Technology Cooperation Base of Spinal Cord Injury, Department of Orthopedic Surgery, Tianjin Medical University General Hospital, Tianjin, People's Republic of China,

Background: Spinal cord injury (SCI) is a traumatic disease of the central nervous system, accompanied with high incidence and high disability rate. Tissue engineering scaffold can be used as therapeutic systems to provide effective repair for SCI.

Purpose: In this study, a novel tissue engineering scaffold has been synthesized in order to explore the effect of nerve repair on SCI. Read More

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http://dx.doi.org/10.2147/IJN.S175914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186894PMC
December 2018
1 Read

Postnatal neural crest stem cells from hair follicle interact with nerve tissue in vitro and in vivo.

Tissue Cell 2018 Oct 18;54:94-104. Epub 2018 Aug 18.

Koltzov Institute of Developmental Biology of the Russian Academy of Sciences, Vavilova 26, 119334, Moscow, Russian Federation; Pirogov Russian National Research Medical University, Ostrovitianova 1, 117997, Moscow, Russian Federation; Lomonosov Moscow State University, Leninskie Gory 1, Moscow, Russian Federation.

Neural crest stem cells that located in the postnatal hair follicle (HF-NCSC) are considered a promising tool for treatment of nervous system diseases and injuries. It is well known that HF-NCSC can be used in the spinal cord and sciatic nerve reparation but their ability to restore brain structures is poorly studied. In this article we are investigating the interaction between HF-NCSC and a nerve tissue (embryonic and adult). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00408166173041
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http://dx.doi.org/10.1016/j.tice.2018.08.005DOI Listing
October 2018
5 Reads

A population-based analysis of outcomes after repair of thoracic aortic emergencies in trauma.

J Surg Res 2018 Nov 29;231:352-360. Epub 2018 Jun 29.

Trauma Service, Scripps Mercy Hospital (MER-62), San Diego, California.

Background: Large-scale assessments of outcomes in thoracic endovascular repair (TEVAR) for thoracic aortic emergencies are lacking. We evaluated perioperative outcomes of TEVAR compared with open surgery among trauma patients in a large statewide database.

Materials And Methods: We evaluated the California Office of Statewide Health Planning and Development 2007-2014 patient discharge database. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804183038
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http://dx.doi.org/10.1016/j.jss.2018.06.003DOI Listing
November 2018
1 Read

Long Term Follow-Up Results of Spinal Concussion Cases: Definition of Late Injuries of the Spinal Cord.

Authors:
Ziya Asan

World Neurosurg 2018 Dec 25;120:e1325-e1330. Epub 2018 Sep 25.

Department of Neurosurgery, Faculty of Medicine, Ahi Evran University, Kirsehir, Turkey. Electronic address:

Objective: This study aims to evaluate the long-term clinical and radiologic findings of cases diagnosed with spinal concussion and to describe the spinal cord injuries that are detected in the later course.

Methods: Data obtained from 91 cases, who had been diagnosed with spinal concussion, were retrospectively evaluated. These were placed in 2 groups according to the type of trauma (axial forces or vertical forces). Read More

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http://dx.doi.org/10.1016/j.wneu.2018.09.078DOI Listing
December 2018
3 Reads

Mulberrin (Mul) reduces spinal cord injury (SCI)-induced apoptosis, inflammation and oxidative stress in rats via miroRNA-337 by targeting Nrf-2.

Biomed Pharmacother 2018 Nov 4;107:1480-1487. Epub 2018 Sep 4.

Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun 130000, China. Electronic address:

Spinal cord injury (SCI) is a major reason of paralysis, disability and even death in severe cases. Mulberrin (Mul) is a major compound of ramulus mori and turned out that it has potent ability on tyrosinase inhibition. Ramulus mori has been reported to possess anti-inflammation, anti-oxidative stress and anti-apoptosis effects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07533322183330
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http://dx.doi.org/10.1016/j.biopha.2018.07.082DOI Listing
November 2018
11 Reads
2.020 Impact Factor

Clinical and Radiologic Features of Osteoporotic Spine Fracture with Delayed Neurologic Compromises.

World Neurosurg 2018 Dec 19;120:e1295-e1300. Epub 2018 Sep 19.

Department of Orthopedic Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Objectives: Osteoporotic spine fractures (OSFs) with delayed neurologic compromises (NCs) have been increasingly reported. Although several studies have addressed that the pathologic mechanism of NC involves nonunion and segmental instability, the risk factors remain unclear. Therefore, the purpose of this study was to assess the radiologic and clinical features of OSFs with delayed NC. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.09.056DOI Listing
December 2018
2 Reads
2.420 Impact Factor

Towards rationally designed biomanufacturing of therapeutic extracellular vesicles: impact of the bioproduction microenvironment.

Biotechnol Adv 2018 12 12;36(8):2051-2059. Epub 2018 Sep 12.

Fischell Department of Bioengineering, University of Maryland, 3102 A. James Clark Hall, College Park, MD 20742, United States; Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, Baltimore, MD 21201, United States; Program in Molecular and Cell Biology, University of Maryland, College Park, MD 20742, United States. Electronic address:

Extracellular vesicles (EVs), including exosomes, microvesicles, and others, have emerged as potential therapeutics for a variety of applications. Pre-clinical reports of EV efficacy in treatment of non-healing wounds, myocardial infarction, osteoarthritis, traumatic brain injury, spinal cord injury, and many other injuries and diseases demonstrate the versatility of this nascent therapeutic modality. EVs have also been demonstrated to be effective in humans, and clinical trials are underway to further explore their potential. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07349750183015
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http://dx.doi.org/10.1016/j.biotechadv.2018.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250573PMC
December 2018
30 Reads

Effects of ursolic acid on sub-lesional muscle pathology in a contusion model of spinal cord injury.

PLoS One 2018 29;13(8):e0203042. Epub 2018 Aug 29.

Department of Biology, Drexel University, Philadelphia, Pennsylvania, United States of America.

Spinal Cord Injury (SCI) results in severe sub-lesional muscle atrophy and fiber type transformation from slow oxidative to fast glycolytic, both contributing to functional deficits and maladaptive metabolic profiles. Therapeutic countermeasures have had limited success and muscle-related pathology remains a clinical priority. mTOR signaling is known to play a critical role in skeletal muscle growth and metabolism, and signal integration of anabolic and catabolic pathways. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203042PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114926PMC
February 2019

Changes of Spinal Edema and Expression of Aquaporin 4 in Methylprednisolone-treated Rats with Spinal Cord Injury.

Ann Clin Lab Sci 2018 Jul;48(4):453-459

Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun, China.

The aim of the current study was to investigate the impact of methylprednisolone (MP) on the expression of Aquaporin 4 (AQP4) and spinal edema in rats with acute spinal cord injury (ASCI). Sprague-Dawley (SD) Wistar rats were randomly divided into the following groups: control (C), sham operation (S), ASCI, and MP-treated. After the ASCI model was induced and prepared, 30 mg/kg MP was injected via the tail vein, on postoperative days 1, 3, and 7. Read More

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July 2018
1 Read

Venous Thromboembolism in Patients with Acute Thoracolumbar Spinal Cord Injury.

Acta Med Okayama 2018 Aug;72(4):375-378

Department of Orthopaedic Surgery, Okayama University Hospital, Okayama 700-8558,

Venous thromboembolism (VTE) is a major complication in patients with acute spinal cord injury. There are few reports of VTE with acute thoracolumbar spinal cord injury (TLSCI). We assessed the incidence of VTE with acute TLSCI using color Doppler ultrasonography. Read More

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http://dx.doi.org/10.18926/AMO/56173DOI Listing

Disc herniation caused by a viscoelastic nucleus after total lumbar disc replacement-a case report.

J Spine Surg 2018 Jun;4(2):478-482

Department of Neurosurgery, Trauma Center Murnau, Murnau, Germany.

Degenerative disc disease (DDD) is highly prevalent. If conservative treatment fails, spinal fusion procedures are commonly performed. Total disc replacement (TDR) might be a surgical option for a distinct subset of patients with DDD. Read More

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http://dx.doi.org/10.21037/jss.2018.05.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046337PMC
June 2018
1 Read

Spotlight on postural control in patients with multiple sclerosis.

Degener Neurol Neuromuscul Dis 2018 3;8:25-34. Epub 2018 Apr 3.

Department of Neurology and Psychiatry, Sapienza University, Rome, Italy.

Multiple sclerosis (MS) is a disease that heavily affects postural control, predisposing patients to accidental falls and fall-related injuries, with a relevant burden on their families, health care systems and themselves. Clinical scales aimed to assess balance are easy to administer in daily clinical setting, but suffer from several limitations including their variable execution, subjective judgment in the scoring system, poor performance in identifying patients at higher risk of falls, and statistical concerns mainly related to distribution of their scores. Today we are able to objectively and reliably assess postural control not only with laboratory-grade standard force platform, but also with low-cost systems based on commercial devices that provide acceptable comparability to gold-standard equipment. Read More

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http://dx.doi.org/10.2147/DNND.S135755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053902PMC
April 2018
13 Reads

Modulation of Neuroinflammation by Taklisodok-um in a Spinal Cord Injury Model.

Neuroimmunomodulation 2018 25;25(2):73-79. Epub 2018 Jul 25.

Objective: Chronic neuroinflammation after spinal cord injury (SCI) is associated with spinal cord damage and functional impairment. In patients, SCI is associated with severe disability, an extensive rehabilitation requirement, and high cost burden. Moreover, there is no effective treatment for SCI. Read More

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http://dx.doi.org/10.1159/000490705DOI Listing
January 2019

Eugenol promotes functional recovery and alleviates inflammation, oxidative stress, and neural apoptosis in a rat model of spinal cord injury.

Restor Neurol Neurosci 2018 ;36(5):659-668

Department of Physical Medicine and Rehabilitation, The Second Hospital of Shandong University, Shandong University, Jinan, Shandong, PR China.

Background: Eugenol, a natural phenolic compound found in essential oils, shows a variety of remedial properties, while its effect on spinal cord injury (SCI) is still unknown.

Objective: To study the effects of Eugenol on SCI-related impairments in rats.

Methods: Rats received SCI or sham surgery were administered by oral gavage with Eugenol or physiological saline 6 hours following SCI and once a day for seven consecutive weeks. Read More

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http://dx.doi.org/10.3233/RNN-180826DOI Listing
November 2018
2 Reads

Effects of MicroRNA-494 on Astrocyte Proliferation and Synaptic Remodeling in the Spinal Cord of a Rat Model of Chronic Compressive Spinal Cord Injury by Regulating the Nogo/Ngr Signaling Pathway.

Cell Physiol Biochem 2018 23;48(3):919-933. Epub 2018 Jul 23.

Background/aims: Chronic compression of the spinal cord causes the loss of motor neurons in the anterior horn, but the precise and extensive mechanism for the loss is not completely determined. Therefore, this study aims to explore the role of microRNA-494 (miR-494) in the proliferation of astrocytes and in the synaptic remodeling in the spinal cord of a rat model of chronic spinal cord injury (SCI) by regulating the Nogo/NgR signaling pathway.

Methods: A rat model of chronic, compressive SCI was established, and the spinal cord state, blood supply changes, and astrocyte apoptosis were observed. Read More

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http://dx.doi.org/10.1159/000491959DOI Listing
September 2018
28 Reads

Astrocyte Neuroprotection and Dehydroepiandrosterone.

Vitam Horm 2018 19;108:175-203. Epub 2018 Feb 19.

Laboratório de Interação Neuro-Humoral, ICBS, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.

Dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) are the most abundant steroid hormones in the systemic circulation of humans. Due to their abundance and reduced production during aging, these hormones have been suggested to play a role in many aspects of health and have been used as drugs for a multiple range of therapeutic actions, including hormonal replacement and the improvement of aging-related diseases. In addition, several studies have shown that DHEA and DHEAS are neuroprotective under different experimental conditions, including models of ischemia, traumatic brain injury, spinal cord injury, glutamate excitotoxicity, and neurodegenerative diseases. Read More

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http://dx.doi.org/10.1016/bs.vh.2018.01.004DOI Listing
November 2018
3 Reads

Evaluation of the Capabilities of Upper Extremity Test (CUE-T) in Children With Tetraplegia.

Top Spinal Cord Inj Rehabil 2018 ;24(3):239-251

Department of Occupational Therapy, Jefferson College of Health Professions, Jefferson (Philadelphia University + Thomas Jefferson University), Philadelphia, Pennsylvania.

The Capabilities of Upper Extremity Test (CUE-T) is a spinal cord injury (SCI)-specific instrument based on the CUE Questionnaire (CUE-Q). To evaluate the psychometric properties of CUE-T in children with cervical SCI and determine the lowest age appropriate for test administration. In this repeated measures multicenter study, 39 youths, mean age 12. Read More

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http://dx.doi.org/10.1310/sci2403-239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037325PMC
October 2018
15 Reads

Early Systemic Alterations in Severe Spinal Cord Injury: An Experimental Study on the Impact of Injury Level on Renal Function.

Spine (Phila Pa 1976) 2018 08;43(15):E885-E890

Proyecto Camina A.C., Cd. México, México.

Study Design: An experimental model of spinal cord injury (SCI) intended to characterize changes in renal function.

Objective: The aim of this study was to evaluate the possible influence of SCI level on renal function during spinal shock.

Summary Of Background Data: SCI triggers multiple systemic and metabolic alterations. Read More

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http://dx.doi.org/10.1097/BRS.0000000000002578DOI Listing
August 2018
9 Reads

Tactile Sensor-Based Steering as a Substitute of the Attendant Joystick in Powered Wheelchairs.

IEEE Trans Neural Syst Rehabil Eng 2018 Jul;26(7):1381-1390

Attendant joysticks of powered wheelchairs are devices oriented to help caregivers. Diseases and disabilities such as dementia, spinal cord injuries or blindness make the user unable to drive the chair by his or her own. However, this device is not intuitive to use, especially for old people. Read More

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http://dx.doi.org/10.1109/TNSRE.2018.2838326DOI Listing
July 2018
1 Read

Implementation and initial outcomes of a spinal cord injury home care program at a large veterans affairs medical center.

J Spinal Cord Med 2018 Jul 2:1-8. Epub 2018 Jul 2.

a VA North Texas Health Care System , Dallas , Texas , USA.

Objectives: Describe an interdisciplinary spinal cord injury home care program (SCIHCP), sample demographics for the veteran participants, and initial impact of SCIHCP on health care utilization and mortality.

Design: Retrospective review.

Setting: SCIHCP of the Spinal Cord Injury Center, VA North Texas Health Care System (VANTHCS). Read More

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http://dx.doi.org/10.1080/10790268.2018.1485311DOI Listing
July 2018
13 Reads

Associations between lean mass and leptin in men with chronic spinal cord injury: Results from the FRASCI-muscle study.

PLoS One 2018 27;13(6):e0198969. Epub 2018 Jun 27.

Department of Physical Medicine and Rehabilitation, University of Colorado School of Medicine, Aurora, Colorado, United States of America.

Leptin is an adipo-myokine that regulates appetite and energy expenditure by a neuroendocrine feedback loop. Leptin levels are positively correlated with BMI in the spinal cord injury population and leptin levels are greater in individuals with spinal cord injury compared to uninjured controls. Leptin is produced in multiple tissues, including fat, bone, and skeletal muscle and is a putative biomarker of sedentary behavior in older adults. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198969PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021064PMC
December 2018
1 Read

[Precise application of Traditional Chinese Medicine in minimally-invasive techniques].

Authors:
Fu-Hui Dong

Zhongguo Gu Shang 2018 06;31(6):493-496

Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China;

The miminally-invasive techniques of traditional Chinese medicine(TCM) uses different types of acupuncture needles to treat diseased locations with special techniques. These techniques include different methods of insertion and closed incision (press cutting, sliding cutting, scrape cutting, etc.). Read More

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http://dx.doi.org/10.3969/j.issn.1003-0034.2018.06.001DOI Listing
June 2018
8 Reads

The role of mutated SOD1 gene in synaptic stripping and MHC class I expression following nerve axotomy in ALS murine model.

Eur J Histochem 2018 May 17;62(2):2904. Epub 2018 May 17.

University of Kentucky Medical Center.

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by motoneuron death. Several cellular pathways have been described to be involved in ALS pathogenesis; however, the involvement of presynaptic stripping and the related MHC class I molecules in mutant SOD1 motoneurons remains to be clarified. To this purpose, we here investigated, for the first time, the motoneurons behavior, di per seand after facial axonal injury, in terms of synaptic stripping and MHC class I expression in wild-type (Wt) mice and in a murine model of ALS, the SOD1(G93A) mice, at the presymptomatic and symptomatic stage of the disease. Read More

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http://dx.doi.org/10.4081/ejh.2018.2904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966710PMC

ATF2, but not ATF3, participates in the maintenance of nerve injury-induced tactile allodynia and thermal hyperalgesia.

Mol Pain 2018 Jan-Dec;14:1744806918787427. Epub 2018 Jun 19.

1 Neurobiology of Pain Laboratory, Departamento de Farmacobiología, Cinvestav, Mexico.

Transcription factors are proteins that modulate the transcriptional rate of target genes in the nucleus in response to extracellular or cytoplasmic signals. Activating transcription factors 2 (ATF2) and 3 (ATF3) respond to environmental signals and maintain cellular homeostasis. There is evidence that inflammation and nerve injury modulate ATF2 and ATF3 expression. Read More

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http://dx.doi.org/10.1177/1744806918787427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050803PMC
December 2018
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Immune-evasive gene switch enables regulated delivery of chondroitinase after spinal cord injury.

Brain 2018 Aug;141(8):2362-2381

King's College London, Regeneration Group, The Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), Guy's Campus, London Bridge, London, SE1 1UL, UK.

Chondroitinase ABC is a promising preclinical therapy that promotes functional neuroplasticity after CNS injury by degrading extracellular matrix inhibitors. Efficient delivery of chondroitinase ABC to the injured mammalian spinal cord can be achieved by viral vector transgene delivery. This approach dramatically modulates injury pathology and restores sensorimotor functions. Read More

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http://dx.doi.org/10.1093/brain/awy158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061881PMC
August 2018
8 Reads

Lifelong Impacts of Moderate Prenatal Alcohol Exposure on Neuroimmune Function.

Front Immunol 2018 22;9:1107. Epub 2018 May 22.

Department of Neurosciences, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, United States.

alcohol exposure is emerging as a major risk factor for lifelong aberrant neuroimmune function. Fetal alcohol spectrum disorder encompasses a range of behavioral and physiological sequelae that may occur throughout life and includes cognitive developmental disabilities as well as disease susceptibility related to aberrant immune and neuroimmune actions. Emerging data from clinical studies and findings from animal models support that of fetal alcohol exposure may reprogram the developing central nervous system leading to altered neuroimmune and neuroglial signaling during adulthood. Read More

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http://dx.doi.org/10.3389/fimmu.2018.01107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992426PMC

Personality, High-Risk Behaviors, and Elevated Risk of Unintentional Deaths Related to Drug Poisoning Among Individuals With Spinal Cord Injury.

Arch Phys Med Rehabil 2018 Oct 13;99(10):1941-1948. Epub 2018 Jun 13.

College of Health Professions, Medical University of South Carolina, Charleston, SC.

Objective: To identify risk and protective factors for unintentional death related to drug poisoning from prescription medications, including opioid-related deaths, and death due to all other causes among participants with spinal cord injury (SCI).

Design: Prospective cohort study.

Setting: Large specialty hospital in the southeastern United States. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00039993183036
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http://dx.doi.org/10.1016/j.apmr.2018.05.013DOI Listing
October 2018
21 Reads

FNDC5 expression in Purkinje neurons of adult male rats with acute spinal cord injury following treatment with methylprednisolone.

Neuropeptides 2018 Aug 7;70:16-25. Epub 2018 May 7.

Department of Medical Basic Sciences, University of social Welfare and Rehabilitation Sciences, Tehran, Iran.

Spinal cord injury (SCI) is a serious and complex medical condition that can happen to anyone. At present, therapy mainly focuses on rehabilitation and pharmacological treatment, such as methylprednisolone (MP). Supra-spinal changes in certain structures, such as the cerebellum, that receive many afferents from the spinal cord might be one reason for unsuccessful therapeutic outcomes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01434179183000
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http://dx.doi.org/10.1016/j.npep.2018.05.002DOI Listing
August 2018
25 Reads

Epidemiological Trends of Traumatic Brain and Spinal Cord Injury in Puerto Rico from November 10th, 2006, through May 24th, 2011.

P R Health Sci J 2018 Jun;37(2):67-77

Auxiliary Researcher III, Department of Surgery, University of Puerto Rico Medical Sciences Campus, San Juan, PR.

Objective: According to the Centers for Disease Control and Prevention (CDC), injury to the central nervous system (CNS) continues to be a leading cause of injury-related morbidity and mortality in the US today.

Methods: A prospective cohort study was performed to determine the incidence of all traumatic CNS injuries. Descriptive variables were presented as frequencies and percentages. Read More

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June 2018
21 Reads

The dosage and administration of long-term intrathecal baclofen therapy for severe spasticity of spinal origin.

Spinal Cord 2018 Oct 12;56(10):996-999. Epub 2018 Jun 12.

Department of Orthopaedic Surgery, Spinal Injuries Center, Fukuoka, Japan.

Study Design: Retrospective chart audit.

Objective: To indicate the appropriate baclofen dosage to control severe spasticity of spinal origin and to develop the optimal administration protocol for long-term intrathecal baclofen (ITB) therapy.

Setting: Department of Orthopaedic Surgery, Spinal Injuries Center, Japan. Read More

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http://dx.doi.org/10.1038/s41393-018-0153-4DOI Listing
October 2018
6 Reads

T-cell infiltration into the perilesional cortex is long-lasting and associates with poor somatomotor recovery after experimental traumatic brain injury.

Restor Neurol Neurosci 2018 ;36(4):485-501

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland.

Background: T-lymphocyte (T-cell) invasion into the brain parenchyma is a major consequence of traumatic brain injury (TBI). However, the role of T-cells in the post-TBI functional outcome and secondary inflammatory processes is unknown. We explored the dynamics of T-cell infiltration into the cortex after TBI to establish whether the infiltration relates to post-injury functional impairment/recovery and progression of the secondary injury. Read More

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/RNN-170811DOI Listing
October 2018
25 Reads

Cell Adhesion Molecule Close Homolog of L1 (CHL1) Guides the Regrowth of Regenerating Motor Axons and Regulates Synaptic Coverage of Motor Neurons.

Front Mol Neurosci 2018 24;11:174. Epub 2018 May 24.

Department of Cell Biology and Neuroscience, W. M. Keck Center for Collaborative Neuroscience, Rutgers University, Piscataway, NJ, United States.

The close homolog of L1 (CHL1) is a cell adhesion molecule involved in regulation of neuronal differentiation and survival, neurite outgrowth and axon guidance during development. In the mature nervous system, CHL1 regulates synaptic activity and plasticity. The aim of the present study was to evaluate the influence of CHL1 on peripheral nerve regeneration after trauma. Read More

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http://dx.doi.org/10.3389/fnmol.2018.00174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976800PMC
May 2018
1 Read

The Top 50 Most-Cited Articles on Cervical Spondylotic Myelopathy.

World Neurosurg 2018 Aug 2;116:e1168-e1180. Epub 2018 Jun 2.

Department of Orthopaedics, Ohio State University, Columbus, Ohio, USA. Electronic address:

Background: Cervical spondylotic myelopathy (CSM) occurs due to chronic degenerative changes in the cervical spine causing compression of the spinal cord. CSM has been studied for decades, and numerous articles have been published on the topic. We sought to identify the top 50 most-cited articles on CSM. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183114
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http://dx.doi.org/10.1016/j.wneu.2018.05.191DOI Listing
August 2018
4 Reads

Acrolein Contributes to the Neuropathic Pain and Neuron Damage after Ischemic-Reperfusion Spinal Cord Injury.

Neuroscience 2018 08 29;384:120-130. Epub 2018 May 29.

Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA. Electronic address:

Besides physical insult, spinal cord injury (SCI) can also result from transient ischemia, such as ischemia-reperfusion SCI (I/R SCI) as a postoperative complication. Increasing evidence has suggested that oxidative stress and related reactive aldehyde species are key contributors to cellular injury after SCI. Previous work in spinal cord contusion injury has demonstrated that acrolein, both a key product and an instigator of oxidative stress, contributes to post-traumatic hyperalgesia. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2018.05.029DOI Listing
August 2018
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Detecting malnutrition risk and obesity after spinal cord injury: a quality improvement project and systematic review.

Eur J Clin Nutr 2018 Nov 30;72(11):1555-1560. Epub 2018 May 30.

National Spinal Injuries Centre, Stoke Mandeville Hospital, Aylesbury, UK.

Background/objectives: Malnutrition and overweight are a major concern after spinal cord injury (SCI). There is limited information available for prevalence of malnutrition, overweight and nutrition screening compliance. The aim of this study is to (1) determine whether the quality improvement initiative is successful in improving nutrition screening and to (2) systematic review the literature on prevalence of malnutrition and overweight after SCI. Read More

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http://dx.doi.org/10.1038/s41430-018-0194-yDOI Listing
November 2018
5 Reads