2,112 results match your criteria Spinal Cord Trauma and Related Diseases


Neurogenic heterotopic ossifications develop independently of granulocyte-colony stimulating factor and neutrophils.

J Bone Miner Res 2020 Jun 22. Epub 2020 Jun 22.

The University of Queensland, Mater Research Institute, Translational Research Institute, Woolloongabba, Queensland, Australia.

Neurogenic heterotopic ossifications (NHO) are incapacitating heterotopic bones in periarticular muscles that frequently develop following traumatic brain or spinal cord injuries (SCI). Using our unique model of SCI-induced NHO, we have previously established that mononucleated phagocytes infiltrating injured muscles are required to trigger NHO via the persistent release of the pro-inflammatory cytokine oncostatin M (OSM). As neutrophils are also a major source of OSM, we investigated whether neutrophils also play a role in NHO development after SCI. Read More

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http://dx.doi.org/10.1002/jbmr.4118DOI Listing

Sustaining the National Spinal Cord Injury Registry of Iran (NSCIR-IR) in a Regional Center: Challenges and Solutions.

Iran J Public Health 2020 Apr;49(4):736-743

Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: The National Traumatic Spinal Cord Injury Registry in Iran (NSCIR-IR), was implemented initially in three hospitals as a pilot phase from 11 Oct 2015 to 19 Jun 2016 and has been active in eight centers from 19 Jun 2016. Poursina Hospital, a trauma care referral center in Rasht, Guilan Province of Iran is one of the registry sites, and has been involved in registering eligible patients since 1 Jan 2016. This study aimed to identify the challenges and solutions for sustaining the NSCIR-IR in a regional center. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283190PMC
April 2020
0.576 Impact Factor

[Application value of immature granulocyte count in predicting early infection after spinal operation].

Zhongguo Gu Shang 2019 Oct;32(10):898-903

Department of Trauma and Orthopaedics, Yuncheng Central Hospital, Yuncheng 044000, Shanxi, China;

Objective: To evaluate the early predictive value of immature granulocytes(IGs) in postoperative infection in patients with spinal injury.

Methods: The clinical data of 78 patients with spinal cord injury underwent surgery from October 2016 to October 2018 were collected. There were 57 males and 21 females, aged from 45 to 63 years old with an average of (55. Read More

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http://dx.doi.org/10.3969/j.issn.1003-0034.2019.10.005DOI Listing
October 2019

A new sequential animal model for infection-related non-unions with segmental bone defect.

BMC Musculoskelet Disord 2020 May 27;21(1):329. Epub 2020 May 27.

Unfallklinik Ludwigshafen, Klinik für Unfallchirurgie und Orthopädie, Ludwig-Guttmann-Strasse 13, 67071, Ludwigshafen, Germany.

Background: The treatment of fracture-related infections (FRI) is still a challenge for orthopedic surgeons. The prevalence of FRI is particularly high in open fractures with extensive soft-tissue damage. This study aimed to develop a new two-step animal model for non-unions with segmental bone defects, which could be used to evaluate new innovative bone substitutes to improve the therapeutic options in humans with FRI and bone defects. Read More

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http://dx.doi.org/10.1186/s12891-020-03355-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254709PMC

Outcomes, Microbiology and Antimicrobial Usage in Pressure Ulcer-Related Pelvic Osteomyelitis: Messages for Clinical Practice.

J Bone Jt Infect 2020 26;5(2):67-75. Epub 2020 Mar 26.

NHS Lothian Infection Service, Regional Infectious Diseases Unit, Western General Hospital, Edinburgh, U.K.

: Pressure ulcer-related pelvic osteomyelitis is a relatively under-studied entity in the field of bone infection. We sought to add to the limited evidence base for managing this challenging syndrome. : Cases were identified retrospectively from a surgical database and hospital discharge codes at a U. Read More

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http://dx.doi.org/10.7150/jbji.41779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242403PMC

Pre-existing mental disorder, clinical profile, inpatient services and costs in people hospitalised following traumatic spinal injury: a whole population record linkage study.

Inj Prev 2020 May 15. Epub 2020 May 15.

Justice Health Unit, Centre for Health Equity, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.

Background: Risk of traumatic injury is increased in individuals with mental illness, substance use disorder and dual diagnosis (mental disorders); these conditions will pre-exist among individuals hospitalised with acute traumatic spinal injury (TSI). Although early intervention can improve outcomes for people who experience mental disorders or TSI, the incidence, management and cost of this often complex comorbid health profile is not sufficiently understood. In a whole population cohort of patients hospitalised with acute TSI, we aimed to describe the prevalence of pre-existing mental disorders and compare differences in injury epidemiology, costs and inpatient allied health service access. Read More

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http://dx.doi.org/10.1136/injuryprev-2019-043567DOI Listing

Regulation of autophagy by inhibitory CSPG interactions with receptor PTPσ and its impact on plasticity and regeneration after spinal cord injury.

Exp Neurol 2020 Jun 4;328:113276. Epub 2020 Mar 4.

Case Western Reserve University, School of Medicine, Department of Neurosciences, Cleveland, OH, USA. Electronic address:

Chondroitin sulfate proteoglycans (CSPGs), extracellular matrix molecules that increase dramatically following a variety of CNS injuries or diseases, have long been known for their potent capacity to curtail cell migrations as well as axon regeneration and sprouting. The inhibition can be conferred through binding to their major cognate receptor, Protein Tyrosine Phosphatase Sigma (PTPσ). However, the precise mechanisms downstream of receptor binding that mediate growth inhibition have remained elusive. Read More

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http://dx.doi.org/10.1016/j.expneurol.2020.113276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145755PMC

Refining rodent models of spinal cord injury.

Exp Neurol 2020 Jun 3;328:113273. Epub 2020 Mar 3.

Centre for Neuroscience, Surgery and Trauma, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark St, London E1 2AT, UK. Electronic address:

This report was produced by an Expert Working Group (EWG) consisting of UK-based researchers, veterinarians and regulators of animal experiments with specialist knowledge of the use of animal models of spinal cord injury (SCI). It aims to facilitate the implementation of the Three Rs (Replacement, Reduction and Refinement), with an emphasis on refinement. Specific animal welfare issues were identified and discussed, and practical measures proposed, with the aim of reducing animal use and suffering, reducing experimental variability, and increasing translatability within this critically important research field. Read More

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http://dx.doi.org/10.1016/j.expneurol.2020.113273DOI Listing

Recommendations for evaluation of neurogenic bladder and bowel dysfunction after spinal cord injury and/or disease.

J Spinal Cord Med 2020 03;43(2):141-164

Department of Rehabilitation Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

To provide an overview of clinical assessments and diagnostic tools, self-report measures (SRMs) and data sets used in neurogenic bladder and bowel (NBB) dysfunction and recommendations for their use with persons with spinal cord injury /disease (SCI/D). Experts in SCI/D conducted literature reviews, compiled a list of NBB related assessments and measures, reviewed their psychometric properties, discussed their use in SCI/D and issued recommendations for the National Institutes of Health (NIH), National Institute of Neurological Disorders and Stroke (NINDS) Common Data Elements (CDEs) guidelines. Clinical assessments included 15 objective tests and diagnostic tools for neurogenic bladder and 12 for neurogenic bowel. Read More

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http://dx.doi.org/10.1080/10790268.2019.1706033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054930PMC

Cell Secretome: Basic Insights and Therapeutic Opportunities for CNS Disorders.

Pharmaceuticals (Basel) 2020 Feb 20;13(2). Epub 2020 Feb 20.

Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga 4710-057, Portugal.

Transplantation of stem cells, in particular mesenchymal stem cells (MSCs), stands as a promising therapy for trauma, stroke or neurodegenerative conditions such as spinal cord or traumatic brain injuries (SCI or TBI), ischemic stroke (IS), or Parkinson's disease (PD). Over the last few years, cell transplantation-based approaches have started to focus on the use of cell byproducts, with a strong emphasis on cell secretome. Having this in mind, the present review discusses the current state of the art of secretome-based therapy applications in different central nervous system (CNS) pathologies. Read More

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http://dx.doi.org/10.3390/ph13020031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169381PMC
February 2020

Metformin Promotes Axon Regeneration after Spinal Cord Injury through Inhibiting Oxidative Stress and Stabilizing Microtubule.

Oxid Med Cell Longev 2020 6;2020:9741369. Epub 2020 Jan 6.

Molecular Pharmacology Research Center, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Spinal cord injury (SCI) is a devastating disease that may lead to lifelong disability. Thus, seeking for valid drugs that are beneficial to promoting axonal regrowth and elongation after SCI has gained wide attention. Metformin, a glucose-lowering agent, has been demonstrated to play roles in various central nervous system (CNS) disorders. Read More

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http://dx.doi.org/10.1155/2020/9741369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969994PMC

Zinc promotes functional recovery after spinal cord injury by activating Nrf2/HO-1 defense pathway and inhibiting inflammation of NLRP3 in nerve cells.

Life Sci 2020 Mar 22;245:117351. Epub 2020 Jan 22.

Department of Orthopedics, The First Affifiliated Hospital of Jinzhou Medical University, Jinzhou, China. Electronic address:

Aims: To study the specific therapeutic effect of zinc on spinal cord injury (SCI) and its specific protective mechanism.

Main Methods: The effects of zinc ions on neuronal cells were examined in a mouse SCI model and in vitro. In vivo, neurological function was assessed by Basso Mouse Scaleat (BMS) at 1, 3, 5, 7, 10, 14, 21, and 28 days after spinal cord injury. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117351DOI Listing

Degenerative cervical myelopathy - update and future directions.

Nat Rev Neurol 2020 02 23;16(2):108-124. Epub 2020 Jan 23.

Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada.

Degenerative cervical myelopathy (DCM) is the leading cause of spinal cord dysfunction in adults worldwide. DCM encompasses various acquired (age-related) and congenital pathologies related to degeneration of the cervical spinal column, including hypertrophy and/or calcification of the ligaments, intervertebral discs and osseous tissues. These pathologies narrow the spinal canal, leading to chronic spinal cord compression and disability. Read More

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http://dx.doi.org/10.1038/s41582-019-0303-0DOI Listing
February 2020

[A case of Alexander disease with repeated loss of consciousness and with rapid aggravation of dysbasia by falling].

Rinsho Shinkeigaku 2020 Feb 19;60(2):137-141. Epub 2020 Jan 19.

Department of Neurology, Kyoto Prefectural University of Medicine.

A 41-year-old woman presented with short-stepped gait from 20 years old and with repeated loss of consciousness from 21 years old. She had a deep cerebral white matter lesion on brain MRI at 34 years of age, but she did not reach a definitive diagnosis. At the age of 41, the gait disorder rapidly worsened after fall and fall-related head trauma. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001341DOI Listing
February 2020

Health promotion and cardiovascular risk reduction in people with spinal cord injury: physical activity, healthy diet and maintenance after discharge- protocol for a prospective national cohort study and a preintervention- postintervention study.

BMJ Open 2019 12 31;9(12):e030310. Epub 2019 Dec 31.

Department of Nursing and Nutrition, University College Copenhagen, Copenhagen, Denmark.

Introduction: Spinal cord injury (SCI) predisposes those who suffer from it to physical inactivity and weight gain; consequently, death due to cardiovascular diseases is more frequent among people with SCI than in the general population. The literature documents a consensus about an interdisciplinary multimodal approach for the prevention and treatment of cardiovascular risk factors including overweight and obesity in people with SCI, focusing on diet, physical activity (PA) and behavioural interventions. This study will investigate implementation of recommendations from a recent clinical practice guideline for identification and management of cardiometabolic risk after SCI through multimodal patient education in a subacute clinical setting. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-030310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955524PMC
December 2019

Searching for differentially expressed proteins in spinal cord injury based on the proteomics analysis.

Life Sci 2020 Feb 27;242:117235. Epub 2019 Dec 27.

Department of Orthopedics, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, People's Republic of China.

Aims: We aimed to identify potential differentially expressed proteins that play roles in the spinal cord injury.

Materials And Methods: The mouse model of spinal cord injury was firstly built, followed by grip strength evaluation. Then, isobaric tags for relative and absolute quantization (iTRAQ) analysis was used to identify differentially expressed proteins at 1, 2, 3 and 8 weeks after spinal cord injury. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.117235DOI Listing
February 2020

Hematolymphoid Malignancies Presenting with Spinal Epidural Mass and Spinal Cord Compression: A Case Series with Rare Entities.

Ann Clin Lab Sci 2019 Nov;49(6):818-828

Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA

The epidural space is an uncommon site for involvement by hematolymphoid malignancies, and may present unexpectedly with neurological symptoms related to spinal cord compression. Our objective was to review the clinical and pathologic features of cases with initial presentations of cord compression, subsequently diagnosed as a hematolymphoid malignancy after pathologic examination. Review of the Department of Pathology's archives revealed 15 patients who presented with spinal cord compression due to epidural hematolymphoid malignancies between 2008-2019. Read More

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November 2019

Protective effects of dantrolene and methylprednisolone against spinal cord injury-induced early oxidative damage in rabbit bladder: A comparative experimental study.

Adv Clin Exp Med 2019 Dec;28(12):1697-1704

Department of Pharmacology, School of Medicine, Sakarya University, Turkey.

Background: Spinal cord injury (SCI) may cause dysfunction in the bladder and many distal organs due to systemic inflammatory response and oxidative stress-related injury.

Objectives: We investigated the preventive effects of dantrolene (DNT) and methylprednisolone (MP) on stress-induced tissue damage in rabbit bladder with SCI.

Material And Methods: A total of 35 rabbits were included in this study and they were divided into 5 groups: group 1 - control, group 2 - SCI only, group 3 - SCI and DNT, group 4 - SCI and MP, and group 5 - SCI and DNT+MP. Read More

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http://dx.doi.org/10.17219/acem/110326DOI Listing
December 2019

Congenital exercise ability ameliorates muscle atrophy but not spinal cord recovery in spinal cord injury mouse model.

Int J Med Sci 2019 21;16(12):1549-1556. Epub 2019 Oct 21.

Division of Neurosurgery, Department of Surgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 23142, Taiwan.

Spinal cord injury (SCI) can cause loss of mobility in the limbs, and no drugs, surgical procedures, or rehabilitation strategies provide a complete cure. Exercise capacity is thought to be associated with the causes of many diseases. However, no studies to date have assessed whether congenital exercise ability is related to the recovery of spinal cord injury. Read More

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http://dx.doi.org/10.7150/ijms.37442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909809PMC

[Risk factors for the development and recurrence of pressure ulcers in patients with spinal cord injury: A systematic review.]

Rev Fac Cien Med Univ Nac Cordoba 2019 12 11;76(4):242-256. Epub 2019 Dec 11.

Instituto de Rehabilitación Psicofísica de la Ciudad Autonoma de Buenos Aires.

Introduction: A spinal cord injury refers to the damage suffered in the spinal cord as a result of trauma, disease or degeneration. Every person with spinal cord injury is at risk of developing pressure ulcers, and almost everyone will develop at least one ulcer due to severe pressure during his or her life.

Objective: To identify the studies that detected risk factors for the development and recurrence of pressure ulcers in patients with spinal cord injury; and, if possible, synthesize the evidence to determine whether an association exists between them. Read More

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http://dx.doi.org/10.31053/1853.0605.v76.n4.24906DOI Listing
December 2019

Mesenchymal Stromal Cell-Based Bone Regeneration Therapies: From Cell Transplantation and Tissue Engineering to Therapeutic Secretomes and Extracellular Vesicles.

Front Bioeng Biotechnol 2019 27;7:352. Epub 2019 Nov 27.

Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, Vienna, Austria.

Effective regeneration of bone defects often presents significant challenges, particularly in patients with decreased tissue regeneration capacity due to extensive trauma, disease, and/or advanced age. A number of studies have focused on enhancing bone regeneration by applying mesenchymal stromal cells (MSCs) or MSC-based bone tissue engineering strategies. However, translation of these approaches from basic research findings to clinical use has been hampered by the limited understanding of MSC therapeutic actions and complexities, as well as costs related to the manufacturing, regulatory approval, and clinical use of living cells and engineered tissues. Read More

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http://dx.doi.org/10.3389/fbioe.2019.00352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890555PMC
November 2019

Psychological factors and risk of mortality after spinal cord injury.

J Spinal Cord Med 2019 Dec 3:1-9. Epub 2019 Dec 3.

College of Health Professions, Medical University of South Carolina, Charleston, South Carolina, USA.

Identify the association of personality and purpose in life with competing risks of multiple causes of death after spinal cord injury (SCI), using data from the SCI Longitudinal Health Study. Prospective cohort study with data collected in 1997-1998 and 2007-2009. Mortality status determined as of December 31, 2016. Read More

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http://dx.doi.org/10.1080/10790268.2019.1690766DOI Listing
December 2019

Microglia-Mediated Regulation of Neuropathic Pain: Molecular and Cellular Mechanisms.

Authors:
Makoto Tsuda

Biol Pharm Bull 2019 ;42(12):1959-1968

Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University.

Pain is a defense system that responds rapidly to harmful internal and external stimuli through the somatosensory neuronal pathway. However, damage to the nervous system through cancer, diabetes, infection, autoimmune disease, chemotherapy or trauma often leads to neuropathic pain, a debilitating chronic pain condition. Neuropathic pain is not simply a temporal continuum of acute nociceptive signals from the periphery, but rather due to pathologically altered functions in the nervous system, which shift the net neuronal excitatory balance toward excitation. Read More

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http://dx.doi.org/10.1248/bpb.b19-00715DOI Listing

Parasympathetic Effect Induces Cell Cycle Activation in Upper Limbs of Paraplegic Patients with Spinal Cord Injury.

Int J Mol Sci 2019 Nov 27;20(23). Epub 2019 Nov 27.

Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul 03722, Korea.

The present study aimed to investigate gene expression changes related to cell cycle activation in patients with spinal cord injury (SCI) and to further evaluate the difference between the upper and lower limbs of SCI patients. Fibroblasts were obtained from the upper and lower limbs of SCI patients and healthy subjects. To investigate gene expression profiling in the fibroblasts from SCI patients compared to the healthy subjects, RNA-Seq transcriptome analysis was performed. Read More

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http://dx.doi.org/10.3390/ijms20235982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929129PMC
November 2019

NT-3 Promotes Oligodendrocyte Proliferation and Nerve Function Recovery After Spinal Cord Injury by Inhibiting Autophagy Pathway.

J Surg Res 2020 03 24;247:128-135. Epub 2019 Nov 24.

Department of Orthopadic Trauma, Chief Physician, The Affiliated Hospital of Guizhou Medical University, GuiYang, China.

Background: Spinal cord injury (SCI) is a serious medical problem, leading to lifelong disability and increasing the health burden worldwide. Traditional treatments have limited effects on neuronal function recovery. Previous studies showed that neurotrophin-3 (NT-3) promoted oligodendrocyte survival and improved neuronal functional recovery after SCI. Read More

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http://dx.doi.org/10.1016/j.jss.2019.10.033DOI Listing

Therapeutic Strategies for Oligodendrocyte-Mediated Remyelination.

Authors:
Toru Ogata

Adv Exp Med Biol 2019 ;1190:265-279

Department of Rehabilitation for the Movement Functions, Research Institute, National Rehabilitation Center, Tokorozawa, Saitama, Japan.

Given recent progress in our understanding of oligodendrocyte biology, significant attention has been directed toward cell therapy for myelin repair and remyelination. This trend has been reinforced by findings about the importance of white matter lesions in a variety of central nervous system (CNS) diseases, including demyelinating diseases as well as brain or spinal cord trauma and degenerative disorders such as Alzheimer's disease. Remyelination strategies include the implementation of myelin forming cells and the surrounding conditions and pathological disease context. Read More

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http://dx.doi.org/10.1007/978-981-32-9636-7_17DOI Listing
December 2019

Quality of Life in Patients with Spinal Cord Injury Attending Selected Rehabilitation Centers of Nepal.

J Nepal Health Res Counc 2019 Nov 13;17(3):297-300. Epub 2019 Nov 13.

National Academy of Medical Sciences, National Trauma Centre, Kathmandu, Nepal.

Background: Spinal cord injury is damage to the spinal cord resulting from trauma, diseases or degenerations. The aim of this study is to identify the quality of life among the patients with spinal cord injury in relation to the physical, psychological, social and environmental health.

Methods: This is a cross-sectional study performed within a period of one year in 103 spinal cord injury patients in two different rehabilitation centers of Nepal by using WHOQOL-BREF through face to face interview. Read More

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http://dx.doi.org/10.33314/jnhrc.v17i3.1898DOI Listing
November 2019

Role of the immune system in neuropathic pain.

Authors:
Marzia Malcangio

Scand J Pain 2019 12;20(1):33-37

Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Background Acute pain is a warning mechanism that exists to prevent tissue damage, however pain can outlast its protective purpose and persist beyond injury, becoming chronic. Chronic Pain is maladaptive and needs addressing as available medicines are only partially effective and cause severe side effects. There are profound differences between acute and chronic pain. Read More

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http://dx.doi.org/10.1515/sjpain-2019-0138DOI Listing
December 2019

Identifying skeletal-related events for prostate cancer patients in routinely collected hospital data.

Cancer Epidemiol 2019 12 9;63:101628. Epub 2019 Nov 9.

Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, United Kingdom. Electronic address:

Background: Non-osteoporotic skeletal-related events (SREs) are clinically important markers of disease progression in prostate cancer. We developed and validated an approach to identify SREs in men with prostate cancer using routinely-collected data.

Methods: Patients diagnosed with prostate cancer between January 2010 and December 2013 were identified in the National Prostate Cancer Audit, based on English cancer registry data. Read More

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http://dx.doi.org/10.1016/j.canep.2019.101628DOI Listing
December 2019

Protective Effects of MiR-129-5p on Acute Spinal Cord Injury Rats.

Med Sci Monit 2019 Nov 4;25:8281-8288. Epub 2019 Nov 4.

Department of Orthopedics, Lishui Municipal Central Hospital, Lishui, Zhejiang, China (mainland).

BACKGROUND Spinal cord injury (SCI) is a severe devastating condition associated with serious disability and neurologic deficits. Aberrant micro RNA (miRNA) expression has been related to a variety of central nervous system diseases including SCI. In the present study, we aimed to discover the role of miR-129-5p on SCI. Read More

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http://dx.doi.org/10.12659/MSM.916731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854883PMC
November 2019

Key regulations related to stem cell research.

Rom J Morphol Embryol 2019 ;60(2):723-728

Department of Medical Education, Practical Abilities and Human Sciences, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania;

Medicine is an ever-changing science. Stem cell research is nowadays part of the medicine. After developments and trials for decades, in 1988 it was announced that a variety of diseases and injuries would be cured with new stem cell therapy, such as: cancer, diabetes, Parkinson's, spinal cord injuries and many others. Read More

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The high-affinity IgG receptor FcγRI modulates peripheral nerve injury-induced neuropathic pain in rats.

Mol Brain 2019 10 22;12(1):83. Epub 2019 Oct 22.

Genetics and Aging Research Unit, McCance Center for Brain Health, Department of Neurology, MassGeneral Institute for Neurodegenerative Diseases (MIND), Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.

The Fc gamma receptor I (FcγRI; CD64) is the high-affinity receptor of the immunoglobulin G protein (IgG). It is usually expressed in immune cells and has recently been identified to distribute in the nervous system and play critical roles in various neurological disorders. Presently, the impacts of FcγRI in neuropathic pain was largely unknown. Read More

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http://dx.doi.org/10.1186/s13041-019-0499-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805563PMC
October 2019

Communication with general practitioners: a survey of spinal cord injury physicians' perspectives.

Spinal Cord Ser Cases 2019 13;5:44. Epub 2019 May 13.

2Department of Rehabilitation Medicine, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA USA.

Study Design: An online questionnaire.

Objectives: To gauge spinal cord injury (SCI) specialists' assessment of their communications with general practitioners (GPs). To determine whether economic or health-care system-related factors enhance or inhibit such communication. Read More

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http://dx.doi.org/10.1038/s41394-019-0187-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786350PMC

Development of Wheeled Mobility indicators to advance the quality of spinal cord injury rehabilitation: SCI-High Project.

J Spinal Cord Med 2019 10;42(sup1):130-140

Brain and Spinal Cord Rehabilitation Program, Toronto Rehabilitation Institute - University Health Network , Toronto , Ontario , Canada.

Wheeled mobility is critical for individuals with Spinal Cord Injury or Disease (SCI/D) related paralysis. The World Health Organization (WHO) developed guidelines highlighting eight steps in wheelchair service delivery: (1) referral and appointment; (2) assessment; (3) prescription; (4) funding and ordering; (5) product preparation; (6) fitting; (7) user training; and, (8) follow-up maintenance/repairs. This article describes the processes used to develop structure, process and outcome indicators that reflect the WHO guidelines within the Domain of Wheeled Mobility rehabilitation for Canadians. Read More

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http://dx.doi.org/10.1080/10790268.2019.1647934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783799PMC
October 2019
1 Read

Is there any gender or age-related discrepancy in the waiting time for each step in the surgical management of acute traumatic cervical spinal cord injury?

J Spinal Cord Med 2019 10;42(sup1):233-241

Department of Surgery, Division of Neurosurgery, University of Toronto , Toronto , Canada.

Prior studies indicate that patient's gender and age can influence treatment choices during spine disease management. This study examines whether individual's gender and age at injury onset influence the waiting time for each step in the surgical management of patients with acute traumatic cervical spinal cord injury (atcSCI). Retrospective cohort study. Read More

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http://dx.doi.org/10.1080/10790268.2019.1614291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781466PMC
October 2019
1 Read

Describing the current state of post-rehabilitation health system surveillance in Ontario - an invited review.

J Spinal Cord Med 2019 10;42(sup1):21-33

KITE, Toronto Rehab - University Health Network , Toronto , Ontario , Canada.

Spinal cord injury (SCI) presents numerous physiological, psychosocial, and environmental complexities resulting in significant healthcare system resource demands. To describe the current health system surveillance mechanisms in Ontario, Canada and highlight gaps in health surveillance among adults with SCI across their lifespan. A review of administrative data sources capturing SCI-specific information took place via internet searching and networking among SCI rehabilitation and health services experts with emphasis on functionality, health service utilization, and quality of life data. Read More

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http://dx.doi.org/10.1080/10790268.2019.1605724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781471PMC
October 2019
1 Read

Methods for development of structure, process and outcome indicators for prioritized spinal cord injury rehabilitation Domains: SCI-High Project.

J Spinal Cord Med 2019 10;42(sup1):51-67

KITE, Toronto Rehab - University Health Network , Toronto , Ontario , Canada.

High-quality rehabilitation care following spinal cord injury or disease (SCI/D) is critical for optimizing neurorecovery and long-term health outcomes This manuscript describes the methods used for developing, refining, and implementing a framework of structure, process, and outcome indicators that reflect high-quality rehabilitation among adults with SCI/D in Canada. This quality improvement initiative was comprised of the following processes: (1) prioritization of care Domains by key stakeholders (scientists, clinicians, therapists, patients and stakeholder organizations); (2) assembly of 11 Domain-specific Working Groups including 69 content experts; (3) conduct of literature searches, guideline and best practice reviews, and outcome synthesis by the Project Team; (4) refinement of Domain aim and construct definitions; (5) conduct of cause and effect analysis using Driver diagrams; (6) selection and development of structure, process and outcome indicators; (7) piloting and feasibility analysis of indicators and associated evaluation tools; and, (8) dissemination of the proposed indicators. The Project Team established aims, constructs and related structure, process, and outcome indicators to facilitate uniform measurement and benchmarking across 11 Domains of rehabilitation, at admission and for 18 months thereafter, among adult Canadians by 2020. Read More

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http://dx.doi.org/10.1080/10790268.2019.1647386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781197PMC
October 2019
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Sex-related discrepancies in the epidemiology, injury characteristics and outcomes after acute spine trauma: A retrospective cohort study.

J Spinal Cord Med 2019 10;42(sup1):10-20

Department of Surgery, Division of Neurosurgery, University of Toronto , Toronto , Ontario , Canada.

The potential effects of sex on injury severity and outcomes after acute spine trauma (AST) have been reported in pre-clinical and clinical studies, even though the data are conflicting. This study compared females and males regarding the epidemiology, injury characteristics, and clinical outcomes of AST. Retrospective cohort study. Read More

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http://dx.doi.org/10.1080/10790268.2019.1607055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781464PMC
October 2019
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Conception and development of Sexual Health indicators to advance the quality of spinal cord injury rehabilitation: SCI-High Project.

J Spinal Cord Med 2019 10;42(sup1):68-84

KITE, Toronto Rehab - University Health Network , Toronto , Ontario , Canada.

Although spinal cord injury or disease (SCI/D) results in complex biological and psychosocial impairments that adversely impact an individual's overall quality of sexual life, sexual health is poorly integrated into the current rehabilitation processes. Therefore, it is vital to promote sexual health as a rehabilitation priority. Herein, we describe the selection of Sexual Health structure, process and outcome indicators for adults with SCI/D in the first 18 months after rehabilitation admission. Read More

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http://dx.doi.org/10.1080/10790268.2019.1612642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781482PMC
October 2019
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Cerebrospinal fluid drainage complications during first stage and completion fenestrated-branched endovascular aortic repair.

J Vasc Surg 2020 Apr 26;71(4):1109-1118.e2. Epub 2019 Sep 26.

Advanced Endovascular Aortic Research Program, Division of Vascular and Endovascular Surgery, Mayo Clinic, Rochester, Minn. Electronic address:

Objective: To determine the rates and risk factors of complications related to cerebrospinal fluid drainage (CSFD) during first stage and completion fenestrated-branched endovascular aortic repair (F-BEVAR) of pararenal and thoracoabdominal aortic aneurysms.

Methods: We reviewed the outcomes of 293 consecutive patients enrolled in a prospective, nonrandomized study to investigate outcomes of F-BEVAR between 2013 and 2018. Patients who received CSFD during first-stage thoracic endovascular aortic repair, index F-BEVAR, or completion of temporary aneurysm sac perfusion procedures were included in the analysis. Read More

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http://dx.doi.org/10.1016/j.jvs.2019.06.210DOI Listing
April 2020
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Adenovirus vector‑mediated in vivo gene transfer of nuclear factor erythroid‑2p45‑related factor 2 promotes functional recovery following spinal cord contusion.

Mol Med Rep 2019 Nov 16;20(5):4285-4292. Epub 2019 Sep 16.

Department of Orthopaedics, Yongchuan Affiliated Hospital, Chongqing Medical University, Chongqing 402160, P.R. China.

The aim of the present study was to investigate whether nuclear factor erythroid 2p45‑related factor 2 (Nrf2) overexpression by gene transfer may protect neurons/glial cells and the association between neurons/glial cells and axons in spinal cord injury (SCI). In the present study, Nrf2 recombinant adenovirus (Ad) vectors were constructed. The protein levels of Nrf2 in the nucleus and of the Nrf2‑regulated gene products heme oxygenase‑1 (HO‑1) and NAD (P)H‑quinone oxidoreductase‑1 (NQO1), were detected using western blot analysis in PC12 cells following 48 h of transfection. Read More

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http://dx.doi.org/10.3892/mmr.2019.10687DOI Listing
November 2019

MicroRNA Profiling Reveals Distinct Signatures in Degenerative Rotator Cuff Pathologies.

J Orthop Res 2020 01 4;38(1):202-211. Epub 2019 Oct 4.

Institute of Tendon and Bone Regeneration, Spinal Cord Injury and Tissue Regeneration, Center Salzburg, Paracelsus Medical University, Salzburg, Austria.

MicroRNAs (miRNAs) have emerged as key regulators orchestrating a wide range of inflammatory and fibrotic diseases. However, the role of miRNAs in degenerative shoulder joint disorders is poorly understood. The aim of this explorative case-control study was to identify pathology-related, circulating miRNAs in patients with chronic rotator cuff tendinopathy and degenerative rotator cuff tears (RCT). Read More

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http://dx.doi.org/10.1002/jor.24473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973295PMC
January 2020
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Traumatic spinal cord injuries: A retrospective cohort study of children seen in Western Australia between 1996 and 2016.

J Pediatr Rehabil Med 2019;12(3):235-243

Department of Paediatric Rehabilitation, Princess Margaret Hospital for Children, Perth, WA, Australia.

Purpose: To describe the medical complexity of traumatic spinal cord injury (TSCI) in paediatric patients in Western Australia (WA). Secondly, to determine if Princess Margaret Hospital (PMH) for Children (the tertiary paediatric centre in WA where all TSCI patients are managed) is meeting the requirements of the Australasian Rehabilitation Outcomes Centre (AROC) paediatric rehabilitation minimum data set gathered on each patient.

Methods: Retrospective cohort study of patients seen at PMH between 1996-2016. Read More

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http://dx.doi.org/10.3233/PRM-180545DOI Listing
June 2020
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Moving beyond the glial scar for spinal cord repair.

Nat Commun 2019 08 28;10(1):3879. Epub 2019 Aug 28.

King's College London, Regeneration Group, The Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology & Neuroscience (IoPPN), Guy's Campus, London Bridge, London, SE1 1UL, UK.

Traumatic spinal cord injury results in severe and irreversible loss of function. The injury triggers a complex cascade of inflammatory and pathological processes, culminating in formation of a scar. While traditionally referred to as a glial scar, the spinal injury scar in fact comprises multiple cellular and extracellular components. Read More

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http://dx.doi.org/10.1038/s41467-019-11707-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713740PMC
August 2019
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An E-Learning Program for Increasing Physical Activity Associated Behaviors Among People with Spinal Cord Injury: Usability Study.

JMIR Form Res 2019 Aug 21;3(3):e14788. Epub 2019 Aug 21.

UAB/Lakeshore Research Collaborative, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL, United States.

Background: The majority of people with spinal cord injury (SCI) in the United States are not meeting the recommended guidelines for regular physical activity. Behavior change techniques (eg, goal setting and action planning) that are framed within the principles of the social cognitive theory (self-efficacy and self-regulation) have the potential to enhance physical activity behavior.

Objective: The aim of the study was to develop and test the usability of an electronic learning (e-learning) program for improving social cognitive factors related to physical activity behavior among people with SCI. Read More

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http://dx.doi.org/10.2196/14788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724499PMC
August 2019
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[The application of hybrid operation suite in the management of cerebral and spinal vascular diseases and intracranial hypervascular tumors].

Zhonghua Wai Ke Za Zhi 2019 Aug;57(8):607-615

Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai Neurosurgical Center, Shanghai 200040, China.

To evaluate the effect of hybrid operation suite in the treatment of cerebral and spinal vascular diseases and intracranial hypervascular tumors. A retrospective study was conducted on 132 patients with various cerebral and spinal vascular diseases and intracranial hypervascular tumors who were treated by hybrid surgery at Department of Neurosurgery, Huashan Hospital from October 2016 to December 2017.There were 70 male and 62 female patients with a mean age of 48. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5815.2019.08.009DOI Listing
August 2019
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Animal models of developmental motor disorders: parallels to human motor dysfunction in cerebral palsy.

J Neurophysiol 2019 09 14;122(3):1238-1253. Epub 2019 Aug 14.

George and Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, Rhode Island.

Cerebral palsy (CP) is the most common motor disability in children. Much of the previous research on CP has focused on reducing the severity of brain injuries, whereas very few researchers have investigated the cause and amelioration of motor symptoms. This research focus has had an impact on the choice of animal models. Read More

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http://dx.doi.org/10.1152/jn.00233.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766736PMC
September 2019
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Empirical targets for acute hemodynamic management of individuals with spinal cord injury.

Neurology 2019 09 13;93(12):e1205-e1211. Epub 2019 Aug 13.

From the International Collaboration on Repair Discoveries (J.W.S., C.R.W., B.K.K.); MD/PhD Training Program (J.W.S.), School of Kinesiology (C.R.W.), and Department of Orthopaedics (R.C.-M., J.S., T.A., S. Paquette, N.D., C.G.F., M.F.D.), University of British Columbia; Vancouver Spine Program (L.M.B., A.T., L.R.), Vancouver General Hospital, British Columbia; Department of Surgery (J.-M.M.-T., S. Parent), Hôpital du Sacré-Coeur de Montréal, and Chu Sainte-Justine (S.C.), Department of Surgery, Université de Montréal, Quebec; Division of Orthopaedic Surgery (C.B.), London Health Sciences Centre, University of Western Ontario, Canada; Department of Neurological Surgery (S.D.), University of California, San Francisco; Vancouver Spine Surgery Institute (R.C.-M., J.S., T.A., S. Paquette, N.D., C.G.F., M.F.D., B.K.K.); and Division of Neurosurgery (B.K.K.), University of British Columbia, Blusson Spinal Cord Centre, Vancouver, Canada.

Objective: To determine the hemodynamic conditions associated with optimal neurologic improvement in individuals with acute traumatic spinal cord injury (SCI) who had lumbar intrathecal catheters placed to measure CSF pressure (CSFP).

Methods: Ninety-two individuals with acute SCI were enrolled in this multicenter prospective observational clinical trial. We monitored mean arterial pressure (MAP) and CSFP during the first week after injury and assessed neurologic function at baseline and 6 months after injury. Read More

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http://dx.doi.org/10.1212/WNL.0000000000008125DOI Listing
September 2019