1,943 results match your criteria Spinal Cord Trauma and Related Diseases


Labour market attachment after mild traumatic brain injury: nationwide cohort study with 5-year register follow-up in Denmark.

BMJ Open 2019 Apr 11;9(4):e026104. Epub 2019 Apr 11.

Department of Psychology, University of Copenhagen, Copenhagen, Denmark.

Objectives: Sickness absence after mild traumatic brain injury (mTBI) is frequent due to postconcussive symptoms. We examined labour market attachment following mTBI up to 5 years postinjury.

Design And Setting: Nationwide cohort study with register follow-up. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026104DOI Listing
April 2019
1 Read

Spine trauma and spinal cord injury in Utah: a geographic cohort study utilizing the National Inpatient Sample.

J Neurosurg Spine 2019 03 29:1-10. Epub 2019 Mar 29.

OBJECTIVE The objective of this study was to investigate the effect of hospital type and patient transfer during the treatment of patients with vertebral fracture and/or spinal cord injury (SCI). METHODS The National Inpatient Sample (NIS) database was queried to identify patients treated in Utah from 2001 to 2011 for vertebral column fracture and/or SCI (ICD-9-CM codes 805, 806, and 952). Variables related to patient transfer into and out of the index hospital were evaluated in relation to patient disposition, hospital length of stay, mortality, and cost. Read More

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http://dx.doi.org/10.3171/2018.12.SPINE18964DOI Listing

Age-related Changes in the Global DNA Methylation Profile of Oligodendrocyte Progenitor Cells Derived from Rat Spinal Cords.

Curr Med Sci 2019 Feb 13;39(1):67-74. Epub 2019 Mar 13.

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Demyelination of axons plays an important role in the pathology of many spinal cord diseases and injuries. Remyelination in demyelinated lesions is primarily performed by oligodendrocyte progenitor cells (OPCs), which generate oligodendrocytes in the developing and mature central nervous system. The efficiency of remyelination decreases with age. Read More

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http://dx.doi.org/10.1007/s11596-019-2001-yDOI Listing
February 2019
2 Reads

Precollision Medical Diagnoses Predict Chronic Neck Pain Following Acute Whiplash Trauma.

Clin J Pain 2019 Apr;35(4):304-314

The Research Clinic for Functional Disorders and Psychosomatics, Aarhus University Hospital.

Objectives: The reason why some individuals develop chronic symptoms, whiplash-associated disorder, following whiplash trauma is poorly understood. We explored whether precollision pain-related diagnoses, medically unexplained symptoms, and psychiatric diagnoses are related to whiplash-associated disorder.

Materials And Methods: A cohort of 719 individuals exposed to whiplash trauma and subsequently experiencing symptoms within 72 hours (whiplash-exposed cohort) and 3595 matched controls were included in this observational prospective study. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000683DOI Listing

Anesthetic management in a spinal cord-injured parturient woman with a left hip resection and secondary scoliosis: A case report.

Medicine (Baltimore) 2019 Feb;98(8):e14527

Department of Anesthesiology, West China Second Hospital of Sichuan University, Key Laboratory of Birth Deficits and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China.

Rationale: Pregnancy after spinal cord injury, hip resection, leg amputation, and scoliosis is an uncommon event. Given the specific pathophysiological changes in this patient, an aesthetic management presented a particular challenge. The effects on the physiological changes associated with pregnancy, aesthetic methods, blood loss, autotransfusion from uterine contractions and thrombotic risk had to be considered. Read More

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http://dx.doi.org/10.1097/MD.0000000000014527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408026PMC
February 2019
1 Read

Health factors and spinal cord injury: a prospective study of risk of cause-specific mortality.

Spinal Cord 2019 Feb 25. Epub 2019 Feb 25.

College of Health Professions, Medical University of South Carolina, Charleston, SC, 29403, USA.

Study Design: Prospective cohort study.

Objectives: Identify the risk and protective factors of all-cause and cause-specific mortality among persons with traumatic spinal cord injury (SCI).

Setting: Rehabilitation specialty hospital in the Southeastern United States. Read More

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http://dx.doi.org/10.1038/s41393-019-0264-6DOI Listing
February 2019
1 Read

Impact of Passive Leg Cycling in Persons With Spinal Cord Injury: A Systematic Review.

Top Spinal Cord Inj Rehabil 2019 12;25(1):83-96. Epub 2018 Dec 12.

Spasticity Research Program, West Park Healthcare Centre, Toronto, Ontario, Canada.

Passive leg cycling is an important clinical tool available for rehabilitation after spinal cord injury (SCI). Passive cycling can be used to derive exercise-related benefits in patients with poor motor control. There have been a number of studies examining the effects of passive cycling on a variety of outcomes. Read More

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http://dx.doi.org/10.1310/sci18-00020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368104PMC
April 2019
10 Reads

Comparison of All-Cause and Cause-Specific Mortality of Persons with Traumatic Spinal Cord Injuries to the General Swiss Population: Results from a National Cohort Study.

Neuroepidemiology 2019 Feb 14;52(3-4):205-213. Epub 2019 Feb 14.

Swiss Paraplegic Research, Nottwil, Switzerland.

Background: Traumatic spinal cord injuries (TSCI) are a neurological condition associated with reduced well-being, increased morbidity and reductions in life expectancy. Estimates of all-cause and cause-specific mortality can aid in identifying targets for prevention and management of contributors for premature mortality.

Objectives: To compare all-cause and cause-specific rates of mortality to that of the Swiss general population; to identify differentials in risk of cause-specific mortality according to lesion characteristics. Read More

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http://dx.doi.org/10.1159/000496976DOI Listing
February 2019
1 Read

A review and evaluation of patient-reported outcome measures for spasticity in persons with spinal cord damage: Recommendations from the Ability Network - an international initiative.

J Spinal Cord Med 2019 Feb 13:1-11. Epub 2019 Feb 13.

e Division of Physiatry, Division of Medicine , University of Toronto , Toronto , Canada.

Context: Patient-reported outcome measures (PROMs) are valuable for capturing the impact of spasticity on health-related quality of life (HRQoL) in persons with spinal cord damage (SCD) and evaluating the efficacy of interventions.

Objective: To provide practical guidance for measuring HRQoL in persons with spasticity following SCD.

Methods: Literature reviews identified measures of HRQoL and caregiver burden, utilized in studies addressing spasticity in SCD. Read More

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http://dx.doi.org/10.1080/10790268.2019.1575533DOI Listing
February 2019
1 Read

Short-Term Clinical and Radiographical Outcome after Application of Anchored Intervertebral Spacers in Dogs with Disc-Associated Cervical Spondylomyelopathy.

Vet Comp Orthop Traumatol 2019 Mar 8;32(2):158-164. Epub 2019 Feb 8.

Division of Small Animal Surgery, Department Clinical Veterinary Medicine, Vetsuisse Faculty, Bern, Switzerland.

Objectives:  The purpose of this study was to assess the short-term outcome of a new intervertebral anchored fusion device (C-LOX) for the treatment of disc associated cervical spondylomyelopathy (DA-CSM) in dogs, based on clinical and radiographical follow-up data.

Materials And Methods:  To be included in the study, dogs had to be clinically affected by DA-CSM treated with surgical distraction/stabilization using the anchored intervertebral spacer (C-LOX). Neurological signs, as well as diagnostic imaging performed pre-, immediately postoperatively, and after 6 weeks and 3 months were assessed. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1676592
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http://dx.doi.org/10.1055/s-0038-1676592DOI Listing
March 2019
4 Reads

The Genomic Health of Human Pluripotent Stem Cells: Genomic Instability and the Consequences on Nuclear Organization.

Front Genet 2018 21;9:623. Epub 2019 Jan 21.

Laboratory of Nuclear and Genomic Health, Division of Biosciences, Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, United Kingdom.

Human pluripotent stem cells (hPSCs) are increasingly used for cell-based regenerative therapies worldwide, with embryonic and induced pluripotent stem cells as potential treatments for debilitating and chronic conditions, such as age-related macular degeneration, Parkinson's disease, spinal cord injuries, and type 1 diabetes. However, with the level of genomic anomalies stem cells generate in culture, their safety may be in question. Specifically, hPSCs frequently acquire chromosomal abnormalities, often with gains or losses of whole chromosomes. Read More

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http://dx.doi.org/10.3389/fgene.2018.00623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348275PMC
January 2019

Circular RNA Expression Alteration and Bioinformatics Analysis in Rats After Traumatic Spinal Cord Injury.

Front Mol Neurosci 2018 14;11:497. Epub 2019 Jan 14.

School of Rehabilitation Medicine, Capital Medical University, Beijing, China.

Spinal cord injury (SCI) is mostly caused by trauma. As primary mechanical injury is unavoidable in SCI, a focus on the pathophysiology and underlying molecular mechanisms of SCI-induced secondary injury is necessary to develop promising treatments for SCI patients. Circular RNAs (circRNAs) are associated with various diseases. Read More

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http://dx.doi.org/10.3389/fnmol.2018.00497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339904PMC
January 2019
2 Reads

Bisperoxovanadium Mediates Neuronal Protection through Inhibition of PTEN and Activation of PI3K/AKT-mTOR Signaling after Traumatic Spinal Injuries.

J Neurotrauma 2019 Mar 28. Epub 2019 Mar 28.

2 Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Department of Neurological Surgery and Goodman Campbell Brain and Spine, Indiana University School of Medicine, Indianapolis, Indiana.

Although mechanisms involved in progression of cell death in spinal cord injury (SCI) have been studied extensively, few are clear targets for translation to clinical application. One of the best-understood mechanisms of cell survival in SCI is phosphatidylinositol-3-kinase (PI3K)/Akt and associated downstream signaling. Clear therapeutic efficacy of a phosphatase and tensin homologue (PTEN) inhibitor called bisperoxovanadium (bpV) has been shown in SCI, traumatic brain injury, stroke, and other neurological disease models in both neuroprotection and functional recovery. Read More

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http://dx.doi.org/10.1089/neu.2018.6294DOI Listing
March 2019
2 Reads

Protocatechuic acid improves functional recovery after spinal cord injury by attenuating blood-spinal cord barrier disruption and hemorrhage in rats.

Neurochem Int 2019 Mar 18;124:181-192. Epub 2019 Jan 18.

Age-Related and Brain Diseases Research Center, Kyung Hee University, Seoul, 02447, Republic of Korea; KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul, 02447, Republic of Korea; Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul, 02447, Republic of Korea. Electronic address:

After spinal cord injury (SCI), blood-spinal cord barrier (BSCB) disruption and hemorrhage lead to blood cell infiltration and progressive secondary injuries including inflammation. Inflammatory response is one of the major events resulting in apoptosis, scar formation and neuronal dysfunction after SCI. Here, we investigated whether protocatechuic acid (PCA), a natural phenolic compound, would attenuate BSCB disruption and hemorrhage, leading to functional improvement after SCI. Read More

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http://dx.doi.org/10.1016/j.neuint.2019.01.013DOI Listing
March 2019
6 Reads

GPR17 receptor modulators and their therapeutic implications: review of recent patents.

Expert Opin Ther Pat 2019 Feb 24;29(2):85-95. Epub 2019 Jan 24.

a School of Pharmacy, Medicinal Chemistry Unit , University of Camerino , Camerino , Italy.

Introduction: The GPR17 receptor, phylogenetically related to both purinergic P2Y and CysLT receptors, is mainly expressed in the CNS and, in general, in organs that can typically undergo ischemic damage. This receptor is involved in various pathologies including stroke, brain and spinal cord trauma, multiple sclerosis and in all diseases characterized by neuronal and myelin dysfunction. Therefore, there is a strong needed to identify molecules capable of binding specifically to GPR17 receptors. Read More

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http://dx.doi.org/10.1080/13543776.2019.1568990DOI Listing
February 2019
3 Reads

An Immune-CNS Axis Activates Remote Hippocampal Stem Cells Following Spinal Transection Injury.

Front Mol Neurosci 2018 11;11:443. Epub 2018 Dec 11.

Molecular Neurobiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

External stimuli such as injury, learning, or stress influence the production of neurons by neural stem cells (NSCs) in the adult mammalian brain. These external stimuli directly impact stem cell activity by influencing areas directly connected or in close proximity to the neurogenic niches of the adult brain. However, very little is known on how distant injuries affect NSC activation state. Read More

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https://www.frontiersin.org/article/10.3389/fnmol.2018.00443
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http://dx.doi.org/10.3389/fnmol.2018.00443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299844PMC
December 2018
13 Reads

Individual variations of the human corticospinal tract and its hand-related motor fibers using diffusion MRI tractography.

Brain Imaging Behav 2019 Jan 8. Epub 2019 Jan 8.

Department of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

The corticospinal tract (CST) is one of the most well studied tracts in human neuroanatomy. Its clinical significance can be demonstrated in many notable traumatic conditions and diseases such as stroke, spinal cord injury (SCI) or amyotrophic lateral sclerosis (ALS). With the advent of diffusion MRI and tractography the computational representation of the human CST in a 3D model became available. Read More

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http://link.springer.com/10.1007/s11682-018-0006-y
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http://dx.doi.org/10.1007/s11682-018-0006-yDOI Listing
January 2019
4 Reads

Pre-collision Medical Diagnoses Predict Chronic Neck Pain Following Acute Whiplash-trauma.

Clin J Pain 2018 Dec 26. Epub 2018 Dec 26.

The Research Clinic for Functional Disorders and Psychosomatics, Aarhus University Hospital, Noerrebrogade 44, 8000 Aarhus C, Denmark.

Objectives: The reason why some individuals develop chronic symptoms, whiplash-associated disorder, following whiplash trauma is poorly understood. We explored whether pre-collision pain-related diagnoses, medically unexplained symptoms and psychiatric diagnoses are related to whiplash-associated disorder.

Methods: A cohort of 719 individuals exposed to whiplash trauma and subsequently experiencing symptoms within 72 hours (whiplash-exposed cohort) and 3595 matched controls were included in this observational prospective study. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000683DOI Listing
December 2018
8 Reads
2.527 Impact Factor

The IASP classification of chronic pain for ICD-11: chronic neuropathic pain.

Pain 2019 Jan;160(1):53-59

Department of Neurophysiology, CBTM, Medical Faculty Mannheim of Heidelberg University, Mannheim, Germany.

The upcoming 11th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD) of the World Health Organization (WHO) offers a unique opportunity to improve the representation of painful disorders. For this purpose, the International Association for the Study of Pain (IASP) has convened an interdisciplinary task force of pain specialists. Here, we present the case for a reclassification of nervous system lesions or diseases associated with persistent or recurrent pain for ≥3 months. Read More

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http://Insights.ovid.com/crossref?an=00006396-201901000-0000
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http://dx.doi.org/10.1097/j.pain.0000000000001365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310153PMC
January 2019
22 Reads
5.213 Impact Factor

Inhibition of TREM1 reduces inflammation and oxidative stress after spinal cord injury (SCI) associated with HO-1 expressions.

Biomed Pharmacother 2019 Jan 26;109:2014-2021. Epub 2018 Nov 26.

Orthopedics Department, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Pudong, Shanghai, 201399, China. Electronic address:

Spinal cord injury (SCI) is a devastating event, leading to the progression of chronic neuropathic pain syndrome. Triggering receptor expressed on myeloid cells 1 (TREM1) is an innate immune receptor expressed on neutrophils and monocytes/macrophages. TREM1 enhances inflammatory response in various models of diseases, but its significance in SCI remains unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07533322183468
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http://dx.doi.org/10.1016/j.biopha.2018.08.159DOI Listing
January 2019
14 Reads

A state-of-the-art perspective on microgliopathic pain.

Authors:
Kazuhide Inoue

Open Biol 2018 11 28;8(11). Epub 2018 Nov 28.

Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan

Acute nociceptive pain is an undesirable feeling but has a physiological significance as a warning system for living organisms. Conversely, chronic pain is lacking physiological significance, but rather represents a confusion of nerve functions. The neuropathic pain that occurs after peripheral nerve injury (PNI) is perhaps the most important type of chronic pain because it is refractory to available medications and thus remains a heavy clinical burden. Read More

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http://rsob.royalsocietypublishing.org/lookup/doi/10.1098/rs
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http://dx.doi.org/10.1098/rsob.180154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282071PMC
November 2018
11 Reads

Rapid and robust restoration of breathing long after spinal cord injury.

Nat Commun 2018 11 27;9(1):4843. Epub 2018 Nov 27.

Department of Neurosciences, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.

There exists an abundance of barriers that hinder functional recovery following spinal cord injury, especially at chronic stages. Here, we examine the rescue of breathing up to 1.5 years following cervical hemisection in the rat. Read More

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http://www.nature.com/articles/s41467-018-06937-0
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http://dx.doi.org/10.1038/s41467-018-06937-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258702PMC
November 2018
18 Reads

Balance, gait, and falls in multiple sclerosis.

Handb Clin Neurol 2018 ;159:237-250

Department of Neurology, Oregon Health and Science University, Portland, OR, United States.

Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS) and the most widespread nontraumatic cause of disability in young adults around the world. MS occurs in people of all ages, races, and ethnicities. MS is characterized by clinical symptoms resulting from lesions in the brain, spinal cord, or optic nerves that can affect balance, gait, and fall risk. Read More

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https://linkinghub.elsevier.com/retrieve/pii/B97804446391650
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http://dx.doi.org/10.1016/B978-0-444-63916-5.00015-XDOI Listing
March 2019
17 Reads

Single-center experience with an inner branched arch endograft.

J Vasc Surg 2019 Apr 23;69(4):977-985.e1. Epub 2018 Nov 23.

Department of Vascular Medicine, German Aortic Center, University Heart Center, Hamburg, Germany.

Objective: Whereas open repair is the "gold standard" for most aortic arch diseases, a subgroup of patients might benefit from an endovascular approach. The introduction of branched stent grafts with dedicated design to address the challenges of the ascending aorta and the aortic arch has opened an entirely new area of treatment for these patients. We investigated the early outcomes of branched thoracic endovascular aortic repair (b-TEVAR) in various types of disease of the aortic arch. Read More

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http://dx.doi.org/10.1016/j.jvs.2018.07.076DOI Listing
April 2019
4 Reads

Orthosilicic Acid Accelerates Bone Formation in Human Osteoblast-Like Cells Through the PI3K-Akt-mTOR Pathway.

Biol Trace Elem Res 2018 Nov 12. Epub 2018 Nov 12.

Department of Orthopedics, Qilu Hospital of Shandong University and Spine and Spinal Cord Disease Research Center, Shandong University, Jinan, Shandong, China.

Silicon is one of the essential trace elements in the human body; the deficiency of which may lead to bone diseases. Numerous animal experiments have shown that an appropriate increase in the intake of silicon is beneficial to enhancing bone density and toughness to prevent osteoporosis. However, the molecular mechanisms of the silicon-mediated osteogenesis process have not been sufficiently clarified. Read More

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http://link.springer.com/10.1007/s12011-018-1574-9
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http://dx.doi.org/10.1007/s12011-018-1574-9DOI Listing
November 2018
23 Reads

Traumatic brain injury-induced neuronal damage in the somatosensory cortex causes formation of rod-shaped microglia that promote astrogliosis and persistent neuroinflammation.

Glia 2018 12 30;66(12):2719-2736. Epub 2018 Oct 30.

Department of Neuroscience, The Ohio State University, Columbus, Ohio.

Microglia undergo dynamic structural and transcriptional changes during the immune response to traumatic brain injury (TBI). For example, TBI causes microglia to form rod-shaped trains in the cerebral cortex, but their contribution to inflammation and pathophysiology is unclear. The purpose of this study was to determine the origin and alignment of rod microglia and to determine the role of microglia in propagating persistent cortical inflammation. Read More

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http://dx.doi.org/10.1002/glia.23523DOI Listing
December 2018
19 Reads

Polycaprolactone electrospun fiber scaffold loaded with iPSCs-NSCs and ASCs as a novel tissue engineering scaffold for the treatment of spinal cord injury.

Int J Nanomedicine 2018 10;13:6265-6277. Epub 2018 Oct 10.

International Science and Technology Cooperation Base of Spinal Cord Injury, Department of Orthopedic Surgery, Tianjin Medical University General Hospital, Tianjin, People's Republic of China,

Background: Spinal cord injury (SCI) is a traumatic disease of the central nervous system, accompanied with high incidence and high disability rate. Tissue engineering scaffold can be used as therapeutic systems to provide effective repair for SCI.

Purpose: In this study, a novel tissue engineering scaffold has been synthesized in order to explore the effect of nerve repair on SCI. Read More

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http://dx.doi.org/10.2147/IJN.S175914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186894PMC
December 2018
3 Reads

Serum testosterone levels may influence body composition and cardiometabolic health in men with spinal cord injury.

Spinal Cord 2019 Mar 22;57(3):229-239. Epub 2018 Oct 22.

Spinal Cord Injury and Disorders, Hunter Holmes McGuire VA Medical Center, Richmond, VA, USA.

Study Design: Cross-sectional study.

Objective: To establish the association between serum testosterone (T) levels, biomarkers of cardiometabolic health and regional body composition variables after spinal cord injury (SCI).

Setting: Medical research center. Read More

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http://dx.doi.org/10.1038/s41393-018-0207-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397667PMC

Whether Visual-related Structural and Functional Changes Occur in Brain of Patients with Acute Incomplete Cervical Cord Injury: A Multimodal Based MRI Study.

Neuroscience 2018 11 14;393:284-294. Epub 2018 Oct 14.

Department of Radiology, Xuanwu Hospital, Capital Medical University, No. 45 Chang-chun St, Xicheng District, Beijing, PR China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, No. 45 Chang-chun St, Xicheng District, Beijing, PR China. Electronic address:

Visual-related cortex plays an important role in the process of movement. It is of great importance to clarify whether traumatic spinal cord injury (SCI), which is a typical disease that results in sensorimotor dysfunction, leads to the alteration of visual-related brain structure and function area. To address this issue, multimodality MRI was applied on eleven patients with acute incomplete cervical cord injury (ICCI) and eleven healthy controls (HCs) to explore possible structural and functional changes of the brain. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03064522183067
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http://dx.doi.org/10.1016/j.neuroscience.2018.10.014DOI Listing
November 2018
9 Reads

Postnatal neural crest stem cells from hair follicle interact with nerve tissue in vitro and in vivo.

Tissue Cell 2018 Oct 18;54:94-104. Epub 2018 Aug 18.

Koltzov Institute of Developmental Biology of the Russian Academy of Sciences, Vavilova 26, 119334, Moscow, Russian Federation; Pirogov Russian National Research Medical University, Ostrovitianova 1, 117997, Moscow, Russian Federation; Lomonosov Moscow State University, Leninskie Gory 1, Moscow, Russian Federation.

Neural crest stem cells that located in the postnatal hair follicle (HF-NCSC) are considered a promising tool for treatment of nervous system diseases and injuries. It is well known that HF-NCSC can be used in the spinal cord and sciatic nerve reparation but their ability to restore brain structures is poorly studied. In this article we are investigating the interaction between HF-NCSC and a nerve tissue (embryonic and adult). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00408166173041
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http://dx.doi.org/10.1016/j.tice.2018.08.005DOI Listing
October 2018
5 Reads

Replication and novel analysis of age and sex effects on the neurologic and functional value of each spinal segment in the US healthcare setting.

Spinal Cord 2019 Feb 5;57(2):156-164. Epub 2018 Oct 5.

Department of Physical Medicine and Rehabilitation, MetroHealth Medical Center, Institute for Functional Restoration, Case Western Reserve University, Cleveland, OH, USA.

Study Design: Replication of previously developed prognostic model.

Objectives: In motor complete injuries at admission to rehabilitation, perform; (1) replication analyses of the relationships between ISNCSCI motor level and motor scores and SCIM and (2) novel analyses to determine if age and/or sex moderate relationship between neurological impairment and function.

Setting: Admission to initial inpatient rehabilitation in the United States. Read More

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http://www.nature.com/articles/s41393-018-0206-8
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http://dx.doi.org/10.1038/s41393-018-0206-8DOI Listing
February 2019
10 Reads

A population-based analysis of outcomes after repair of thoracic aortic emergencies in trauma.

J Surg Res 2018 11 29;231:352-360. Epub 2018 Jun 29.

Trauma Service, Scripps Mercy Hospital (MER-62), San Diego, California.

Background: Large-scale assessments of outcomes in thoracic endovascular repair (TEVAR) for thoracic aortic emergencies are lacking. We evaluated perioperative outcomes of TEVAR compared with open surgery among trauma patients in a large statewide database.

Materials And Methods: We evaluated the California Office of Statewide Health Planning and Development 2007-2014 patient discharge database. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804183038
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http://dx.doi.org/10.1016/j.jss.2018.06.003DOI Listing
November 2018
1 Read

Long Term Follow-Up Results of Spinal Concussion Cases: Definition of Late Injuries of the Spinal Cord.

Authors:
Ziya Asan

World Neurosurg 2018 Dec 25;120:e1325-e1330. Epub 2018 Sep 25.

Department of Neurosurgery, Faculty of Medicine, Ahi Evran University, Kirsehir, Turkey. Electronic address:

Objective: This study aims to evaluate the long-term clinical and radiologic findings of cases diagnosed with spinal concussion and to describe the spinal cord injuries that are detected in the later course.

Methods: Data obtained from 91 cases, who had been diagnosed with spinal concussion, were retrospectively evaluated. These were placed in 2 groups according to the type of trauma (axial forces or vertical forces). Read More

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http://dx.doi.org/10.1016/j.wneu.2018.09.078DOI Listing
December 2018
3 Reads

Mulberrin (Mul) reduces spinal cord injury (SCI)-induced apoptosis, inflammation and oxidative stress in rats via miroRNA-337 by targeting Nrf-2.

Biomed Pharmacother 2018 Nov 4;107:1480-1487. Epub 2018 Sep 4.

Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun 130000, China. Electronic address:

Spinal cord injury (SCI) is a major reason of paralysis, disability and even death in severe cases. Mulberrin (Mul) is a major compound of ramulus mori and turned out that it has potent ability on tyrosinase inhibition. Ramulus mori has been reported to possess anti-inflammation, anti-oxidative stress and anti-apoptosis effects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07533322183330
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http://dx.doi.org/10.1016/j.biopha.2018.07.082DOI Listing
November 2018
17 Reads
2.020 Impact Factor

Clinical and Radiologic Features of Osteoporotic Spine Fracture with Delayed Neurologic Compromises.

World Neurosurg 2018 Dec 19;120:e1295-e1300. Epub 2018 Sep 19.

Department of Orthopedic Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Objectives: Osteoporotic spine fractures (OSFs) with delayed neurologic compromises (NCs) have been increasingly reported. Although several studies have addressed that the pathologic mechanism of NC involves nonunion and segmental instability, the risk factors remain unclear. Therefore, the purpose of this study was to assess the radiologic and clinical features of OSFs with delayed NC. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.09.056DOI Listing
December 2018
3 Reads
2.420 Impact Factor

Towards rationally designed biomanufacturing of therapeutic extracellular vesicles: impact of the bioproduction microenvironment.

Biotechnol Adv 2018 12 12;36(8):2051-2059. Epub 2018 Sep 12.

Fischell Department of Bioengineering, University of Maryland, 3102 A. James Clark Hall, College Park, MD 20742, United States; Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, Baltimore, MD 21201, United States; Program in Molecular and Cell Biology, University of Maryland, College Park, MD 20742, United States. Electronic address:

Extracellular vesicles (EVs), including exosomes, microvesicles, and others, have emerged as potential therapeutics for a variety of applications. Pre-clinical reports of EV efficacy in treatment of non-healing wounds, myocardial infarction, osteoarthritis, traumatic brain injury, spinal cord injury, and many other injuries and diseases demonstrate the versatility of this nascent therapeutic modality. EVs have also been demonstrated to be effective in humans, and clinical trials are underway to further explore their potential. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07349750183015
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http://dx.doi.org/10.1016/j.biotechadv.2018.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250573PMC
December 2018
40 Reads

Effects of ursolic acid on sub-lesional muscle pathology in a contusion model of spinal cord injury.

PLoS One 2018 29;13(8):e0203042. Epub 2018 Aug 29.

Department of Biology, Drexel University, Philadelphia, Pennsylvania, United States of America.

Spinal Cord Injury (SCI) results in severe sub-lesional muscle atrophy and fiber type transformation from slow oxidative to fast glycolytic, both contributing to functional deficits and maladaptive metabolic profiles. Therapeutic countermeasures have had limited success and muscle-related pathology remains a clinical priority. mTOR signaling is known to play a critical role in skeletal muscle growth and metabolism, and signal integration of anabolic and catabolic pathways. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203042PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114926PMC
February 2019

Changes of Spinal Edema and Expression of Aquaporin 4 in Methylprednisolone-treated Rats with Spinal Cord Injury.

Ann Clin Lab Sci 2018 Jul;48(4):453-459

Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun, China.

The aim of the current study was to investigate the impact of methylprednisolone (MP) on the expression of Aquaporin 4 (AQP4) and spinal edema in rats with acute spinal cord injury (ASCI). Sprague-Dawley (SD) Wistar rats were randomly divided into the following groups: control (C), sham operation (S), ASCI, and MP-treated. After the ASCI model was induced and prepared, 30 mg/kg MP was injected via the tail vein, on postoperative days 1, 3, and 7. Read More

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July 2018
1 Read

Venous Thromboembolism in Patients with Acute Thoracolumbar Spinal Cord Injury.

Acta Med Okayama 2018 Aug;72(4):375-378

Department of Orthopaedic Surgery, Okayama University Hospital, Okayama 700-8558,

Venous thromboembolism (VTE) is a major complication in patients with acute spinal cord injury. There are few reports of VTE with acute thoracolumbar spinal cord injury (TLSCI). We assessed the incidence of VTE with acute TLSCI using color Doppler ultrasonography. Read More

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http://dx.doi.org/10.18926/AMO/56173DOI Listing

Vitamin D, diet, and lifestyle in a chronic SCI population.

Spinal Cord 2019 Feb 8;57(2):117-127. Epub 2018 Aug 8.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Study Design: Cross-sectional study.

Objectives: Determine dietary, lifestyle, and clinical factors associated with plasma 25-hydroxyvitamin D [25(OH)D] levels in persons with chronic spinal cord injury (SCI).

Setting: Veterans Affairs Medical Center in Boston, MA. Read More

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http://dx.doi.org/10.1038/s41393-018-0148-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359957PMC
February 2019

Disc herniation caused by a viscoelastic nucleus after total lumbar disc replacement-a case report.

J Spine Surg 2018 Jun;4(2):478-482

Department of Neurosurgery, Trauma Center Murnau, Murnau, Germany.

Degenerative disc disease (DDD) is highly prevalent. If conservative treatment fails, spinal fusion procedures are commonly performed. Total disc replacement (TDR) might be a surgical option for a distinct subset of patients with DDD. Read More

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http://dx.doi.org/10.21037/jss.2018.05.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046337PMC
June 2018
1 Read

Effect of mito-TEMPO, a mitochondria-targeted antioxidant, in rats with neuropathic pain.

Neuroreport 2018 10;29(15):1275-1281

Department of Anesthesiology, The Second Hospital of Anhui Medical University.

The therapeutic effects of mitochondria-targeted antioxidants have been demonstrated in many pathological conditions, but their effect on neuropathic pain remains unclear. The objective was to study the therapeutic effects and mechanisms of mito-TEMPO (MT), as a nitroxide conjugated with a triphenylphosphonium moiety, on neuropathic pain in rats. Rats were randomly assigned to sham control (sham), chronic constrictive injury (CCI) or MT treatment groups (sham+MT and CCI+MT). Read More

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http://dx.doi.org/10.1097/WNR.0000000000001105DOI Listing
October 2018
1 Read

Spotlight on postural control in patients with multiple sclerosis.

Degener Neurol Neuromuscul Dis 2018 3;8:25-34. Epub 2018 Apr 3.

Department of Neurology and Psychiatry, Sapienza University, Rome, Italy.

Multiple sclerosis (MS) is a disease that heavily affects postural control, predisposing patients to accidental falls and fall-related injuries, with a relevant burden on their families, health care systems and themselves. Clinical scales aimed to assess balance are easy to administer in daily clinical setting, but suffer from several limitations including their variable execution, subjective judgment in the scoring system, poor performance in identifying patients at higher risk of falls, and statistical concerns mainly related to distribution of their scores. Today we are able to objectively and reliably assess postural control not only with laboratory-grade standard force platform, but also with low-cost systems based on commercial devices that provide acceptable comparability to gold-standard equipment. Read More

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http://dx.doi.org/10.2147/DNND.S135755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053902PMC
April 2018
16 Reads

Bone morphogenetic proteins - 7 and - 2 in the treatment of delayed osseous union secondary to bacterial osteitis in a rat model.

BMC Musculoskelet Disord 2018 Jul 27;19(1):261. Epub 2018 Jul 27.

Clinic for Orthopedics and Trauma Surgery, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Heidelberg University Hospital, Schlierbacher Landstrasse 200a, 69118, Heidelberg, Germany.

Background: Bone infections due to trauma and subsequent delayed or impaired fracture healing represent a great challenge in orthopedics and trauma surgery. The prevalence of such bacterial infection-related types of delayed non-union is high in complex fractures, particularly in open fractures with additional extensive soft-tissue damage. The aim of this study was to establish a rat model of delayed osseous union secondary to bacterial osteitis and investigate the impact of rhBMP-7 and rhBMP-2 on fracture healing in the situation of an ongoing infection. Read More

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http://dx.doi.org/10.1186/s12891-018-2203-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062917PMC
July 2018
8 Reads

Modulation of Neuroinflammation by Taklisodok-um in a Spinal Cord Injury Model.

Neuroimmunomodulation 2018 25;25(2):73-79. Epub 2018 Jul 25.

Objective: Chronic neuroinflammation after spinal cord injury (SCI) is associated with spinal cord damage and functional impairment. In patients, SCI is associated with severe disability, an extensive rehabilitation requirement, and high cost burden. Moreover, there is no effective treatment for SCI. Read More

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http://dx.doi.org/10.1159/000490705DOI Listing
January 2019

Eugenol promotes functional recovery and alleviates inflammation, oxidative stress, and neural apoptosis in a rat model of spinal cord injury.

Restor Neurol Neurosci 2018 ;36(5):659-668

Department of Physical Medicine and Rehabilitation, The Second Hospital of Shandong University, Shandong University, Jinan, Shandong, PR China.

Background: Eugenol, a natural phenolic compound found in essential oils, shows a variety of remedial properties, while its effect on spinal cord injury (SCI) is still unknown.

Objective: To study the effects of Eugenol on SCI-related impairments in rats.

Methods: Rats received SCI or sham surgery were administered by oral gavage with Eugenol or physiological saline 6 hours following SCI and once a day for seven consecutive weeks. Read More

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http://dx.doi.org/10.3233/RNN-180826DOI Listing
November 2018
2 Reads

Effects of MicroRNA-494 on Astrocyte Proliferation and Synaptic Remodeling in the Spinal Cord of a Rat Model of Chronic Compressive Spinal Cord Injury by Regulating the Nogo/Ngr Signaling Pathway.

Cell Physiol Biochem 2018 23;48(3):919-933. Epub 2018 Jul 23.

Background/aims: Chronic compression of the spinal cord causes the loss of motor neurons in the anterior horn, but the precise and extensive mechanism for the loss is not completely determined. Therefore, this study aims to explore the role of microRNA-494 (miR-494) in the proliferation of astrocytes and in the synaptic remodeling in the spinal cord of a rat model of chronic spinal cord injury (SCI) by regulating the Nogo/NgR signaling pathway.

Methods: A rat model of chronic, compressive SCI was established, and the spinal cord state, blood supply changes, and astrocyte apoptosis were observed. Read More

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http://dx.doi.org/10.1159/000491959DOI Listing
September 2018
28 Reads

Astrocyte Neuroprotection and Dehydroepiandrosterone.

Vitam Horm 2018 19;108:175-203. Epub 2018 Feb 19.

Laboratório de Interação Neuro-Humoral, ICBS, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.

Dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) are the most abundant steroid hormones in the systemic circulation of humans. Due to their abundance and reduced production during aging, these hormones have been suggested to play a role in many aspects of health and have been used as drugs for a multiple range of therapeutic actions, including hormonal replacement and the improvement of aging-related diseases. In addition, several studies have shown that DHEA and DHEAS are neuroprotective under different experimental conditions, including models of ischemia, traumatic brain injury, spinal cord injury, glutamate excitotoxicity, and neurodegenerative diseases. Read More

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http://dx.doi.org/10.1016/bs.vh.2018.01.004DOI Listing
November 2018
3 Reads

Isolated nociceptors reveal multiple specializations for generating irregular ongoing activity associated with ongoing pain.

Pain 2018 Nov;159(11):2347-2362

Department of Integrative Biology and Pharmacology, McGovern Medical School at UTHealth, Houston, TX, United States.

Ongoing pain has been linked to ongoing activity (OA) in human C-fiber nociceptors, but rodent models of pain-related OA have concentrated on allodynia rather than ongoing pain, and on OA generated in non-nociceptive Aβ fibers rather than C-fiber nociceptors. Little is known about how ongoing pain or nociceptor OA is generated. To define neurophysiological alterations underlying nociceptor OA, we have used isolated dorsal root ganglion neurons that continue to generate OA after removal from animals displaying ongoing pain. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193853PMC
November 2018
10 Reads

Evaluation of the Capabilities of Upper Extremity Test (CUE-T) in Children With Tetraplegia.

Top Spinal Cord Inj Rehabil 2018 ;24(3):239-251

Department of Occupational Therapy, Jefferson College of Health Professions, Jefferson (Philadelphia University + Thomas Jefferson University), Philadelphia, Pennsylvania.

The Capabilities of Upper Extremity Test (CUE-T) is a spinal cord injury (SCI)-specific instrument based on the CUE Questionnaire (CUE-Q). To evaluate the psychometric properties of CUE-T in children with cervical SCI and determine the lowest age appropriate for test administration. In this repeated measures multicenter study, 39 youths, mean age 12. Read More

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http://dx.doi.org/10.1310/sci2403-239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037325PMC
October 2018
18 Reads