J Neurosci 2013 Oct;33(43):17138-49
Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, Veterans Administration Medical Center, San Diego, California 92161, Spinal Cord Injury Center, Heidelberg University Hospital, D-69118 Heidelberg, Germany, Spinal Cord Research Center, Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129.
High-level spinal cord injury can lead to cardiovascular dysfunction, including disordered hemodynamics at rest and autonomic dysreflexia during noxious stimulation. To restore supraspinal control of sympathetic preganglionic neurons (SPNs), we grafted embryonic brainstem-derived neural stem cells (BS-NSCs) or spinal cord-derived neural stem cells (SC-NSCs) expressing green fluorescent protein into the T4 complete transection site of adult rats. Animals with injury alone served as controls. Read More