931 results match your criteria Spinal Cord Injury and Aging


Decrypting the electrophysiological individuality of the human brain: Identification of individuals based on resting-state EEG activity.

Neuroimage 2019 Apr 9. Epub 2019 Apr 9.

Division Neuropsychology, Institute of Psychology, University of Zurich, Switzerland; University Research Priority Program (URPP) "Dynamic of Healthy Aging", University of Zurich, Switzerland. Electronic address:

Biometric identification (BI) of individuals is a fast-growing field of research that is producing increasingly sophisticated applications in several spheres of everyday life. Previous magnetic resonance imaging (MRI) studies have demonstrated that based on the high inter-individual variability of brain structure and function, it is possible to identify individuals with high accuracy. Otherwise, there is the common belief that electroencephalographic (EEG) data recorded at the surface of the scalp are too noisy for identification purposes with a comparably high hit rate. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.04.005DOI Listing
April 2019
2 Reads

Protective Effects of CISD2 and Influence of Curcumin on CISD2 Expression in Aged Animals and Inflammatory Cell Model.

Nutrients 2019 Mar 25;11(3). Epub 2019 Mar 25.

Department of Biotechnology and Animal Science, College of Bioresources, National Ilan University, Yilan 26047, Taiwan.

Background: Inflammation and mitochondrial dysfunction have been linked to trauma, neurodegeneration, and aging. Impairment of CISD2 expression may trigger the aforementioned pathological conditions in neural cells. We previously reported that curcumin attenuates the downregulation of CISD2 in animal models of spinal cord injury and lipopolysaccharide (LPS)-treated neuronal cells. Read More

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http://dx.doi.org/10.3390/nu11030700DOI Listing

Thermal injury to spinal cord, a rare complication of percutaneous microwave spine tumor ablation: Case report.

J Clin Neurosci 2019 Mar 25. Epub 2019 Mar 25.

Department of Neurosurgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Meyer Building 7-109, Baltimore, MD 21287, United States.

Metastatic disease to the spine are becoming increasingly common with an aging population and improvements in systemic cancer therapies. Surgery, radiation, and vertebroplasty are mainstay modalities for treating painful spine metastases. Recently, image-guided percutaneous ablation techniques have emerged a promising therapeutic option. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.03.018DOI Listing
March 2019
1 Read

Transplantation of adult spinal cord grafts into spinal cord transected rats improves their locomotor function.

Sci China Life Sci 2019 Mar 20. Epub 2019 Mar 20.

Key Laboratory for Nano-Bio Interface Research, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123, China.

Grafted embryonic central neural tissue pieces can recover function of hemisected spinal cord in neonatal rats and promote axonal growth in adults. However, spinal cord segments from adults have not been used as donor segments for allogeneic transplantation. Here, we utilized adult spinal cord tissue grafts (aSCGs) as donor constructs for repairing complete spinal cord injury (SCI). Read More

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http://dx.doi.org/10.1007/s11427-019-9490-8DOI Listing

Impact of secondary health conditions on social role participation for a long-term physical disability cohort.

Psychol Health Med 2019 Mar 25:1-12. Epub 2019 Mar 25.

a Department of Rehabilitation Medicine , University of Washington Department of Rehabilitation Medicine , Seattle, WA , USA.

For people living with long-term physical disability (LTPD) social participation may involve managing physical impairments and secondary health conditions (SHCs) that are not due to the pathophysiology of the LTPD diagnosis itself. Prior research found a negative relationship between SHCs and participation in social roles in people with spinal cord injury (SCI). We expand on this research by investigating the influence of SHCs on participation in social roles for people with one of four LTPDs, controlling for co-variates. Read More

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http://dx.doi.org/10.1080/13548506.2019.1595684DOI Listing

Silencing of lncRNA PKIA-AS1 Attenuates Spinal Nerve Ligation-Induced Neuropathic Pain Through Epigenetic Downregulation of CDK6 Expression.

Front Cell Neurosci 2019 20;13:50. Epub 2019 Feb 20.

Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Xiangya Hospital, Central South University, Changsha, China.

Neuropathic pain (NP) is among the most intractable comorbidities of spinal cord injury. Dysregulation of non-coding RNAs has also been implicated in the development of neuropathic pain. Here, we identified a novel lncRNA, PKIA-AS1, by using lncRNA array analysis in spinal cord tissue of spinal nerve ligation (SNL) model rats, and investigated the role of PKIA-AS1 in SNL-mediated neuropathic pain. Read More

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https://www.frontiersin.org/article/10.3389/fncel.2019.00050
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http://dx.doi.org/10.3389/fncel.2019.00050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401634PMC
February 2019
5 Reads

Age-related Changes in the Global DNA Methylation Profile of Oligodendrocyte Progenitor Cells Derived from Rat Spinal Cords.

Curr Med Sci 2019 Feb 13;39(1):67-74. Epub 2019 Mar 13.

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Demyelination of axons plays an important role in the pathology of many spinal cord diseases and injuries. Remyelination in demyelinated lesions is primarily performed by oligodendrocyte progenitor cells (OPCs), which generate oligodendrocytes in the developing and mature central nervous system. The efficiency of remyelination decreases with age. Read More

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http://dx.doi.org/10.1007/s11596-019-2001-yDOI Listing
February 2019
2 Reads

[Comparison of three different posterior cervical approaches for treating cervical spine trauma with ossification of posterior longitudinal ligament].

Zhonghua Wai Ke Za Zhi 2019 Mar;57(3):176-181

Department of Spine Surgery, Changzheng Hospital, Naval Military Medical University, Shanghai 200003, China.

To investigate the clinical application value of using laminoplasty combine with short-segment pedicle screw fixation in the treatment of cervical spine trauma patients with ossification of posterior longitudinal ligament (OPLL). Fifty-four cervical spine trauma patients with OPLL from June 2014 to June 2016 were retrospectively analyzed of Department of Spine Surgery, Changzheng Hospital, Naval Military Medical University. There were 31 males and 23 females, aging (68. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5815.2019.03.004DOI Listing

Does engagement in productive activities affect mental health and well-being in older adults with a chronic physical disability? Observational evidence from a Swiss cohort study.

Aging Ment Health 2019 Feb 21:1-8. Epub 2019 Feb 21.

a Swiss Paraplegic Research , Guido A. Zäch Institute , Nottwil , Switzerland.

Objectives: To investigate type and load of productive activities as potential determinants of mental health and well-being in elderly persons with a physical disability.

Methods: We used data from a Swiss population-based sample of 314 adults at or past the legal retirement age (65 for men, 64 for women) who live with a chronic physical disability, spinal cord injury. Engagement in housework, volunteering, and paid work were dichotomized (no; some engagement) and three groups of engagement types were constructed (none; housework only; volunteering and/or paid work). Read More

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http://dx.doi.org/10.1080/13607863.2019.1576158DOI Listing
February 2019
1 Read

Understanding the Changing Health Care Needs of Individuals Aging With Spinal Cord Injury.

Top Spinal Cord Inj Rehabil 2019 ;25(1):62-73

Department of Physical Therapy, Thomas Jefferson University, Philadelphia, Pennsylvania.

Individuals over age 65 are projected to account for over 20% of the general population by 2030. This trend is reflected in an increase in the age of individuals sustaining traumatic spinal cord injury (SCI). Based on current evidence, there is concern regarding the needs of older individuals aging with SCI and current health care services. Read More

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http://dx.doi.org/10.1310/sci2501-62DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368105PMC
April 2019
2 Reads

Use of a combination strategy to improve neuroprotection and neuroregeneration in a rat model of acute spinal cord injury.

Neural Regen Res 2019 Jun;14(6):1060-1068

Centro de Investigación en Ciencias de la Salud (CICSA), Facultad de Ciencias de la Salud, Universidad Anáhuac México Campus Norte, Huixquilucan, Edo. de México, México; Centro de Investigación del Proyecto CAMINA A.C.; Ciudad de México, México.

Spinal cord injury is a very common pathological event that has devastating functional consequences in patients. In recent years, several research groups are trying to find an effective therapy that could be applied in clinical practice. In this study, we analyzed the combination of different strategies as a potential therapy for spinal cord injury. Read More

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http://dx.doi.org/10.4103/1673-5374.250627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404491PMC
June 2019
1 Read

Tau drives translational selectivity by interacting with ribosomal proteins.

Acta Neuropathol 2019 Apr 13;137(4):571-583. Epub 2019 Feb 13.

Department of Neuroscience and Center for Translational Research in Neurodegenerative Disease, University of Florida, 1275 Center Drive, BOX 100159, Gainesville, FL, 32610, USA.

There is a fundamental gap in understanding the consequences of tau-ribosome interactions. Tau oligomers and filaments hinder protein synthesis in vitro, and they associate strongly with ribosomes in vivo. Here, we investigated the consequences of tau interactions with ribosomes in transgenic mice, in cells, and in human brain tissues to identify tau as a direct modulator of ribosomal selectivity. Read More

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http://dx.doi.org/10.1007/s00401-019-01970-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426815PMC
April 2019
9 Reads

An epidemiological study of traumatic spinal cord injuries in the fastest aging area in Japan.

Spinal Cord 2019 Feb 7. Epub 2019 Feb 7.

Department of Orthopedic Surgery, Akita Red Cross Hospital, Akita, Japan.

Study Design: Retrospective epidemiological study.

Objective: To investigate the epidemiology of traumatic spinal cord injury (TSCI) in the fastest aging area in Japan.

Setting: Hospitals in Akita Prefecture, Japan. Read More

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http://dx.doi.org/10.1038/s41393-019-0255-7DOI Listing
February 2019

C7 transfer in a posterior intradural approach for treating hemiplegic upper-limbs: hypothesis and a cadaver feasibility study.

Br J Neurosurg 2019 Jan 25:1-5. Epub 2019 Jan 25.

a Department of Hand Surgery , Huashan Hospital, Shanghai Medical College, Fudan University , Shanghai , China.

Objective: Contralateral C7 nerve root transfer surgery has been successfully applied to rescue motor function of a hemiplegic upper extremity in patients with central neurological injury. This surgical technique is challenging, and limited anatomical space makes it difficult to manipulate tissues and may lead to higher complication rates. The authors hypothesis a new surgical route in which cervical nerve roots of both donor and recipient sides are exposed from a posterior intradural approach and neurorrhaphy is performed easily and clearly. Read More

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http://dx.doi.org/10.1080/02688697.2018.1552754DOI Listing
January 2019
3 Reads

Elevated Serum Melatonin under Constant Darkness Enhances Neural Repair in Spinal Cord Injury through Regulation of Circadian Clock Proteins Expression.

J Clin Med 2019 Jan 23;8(2). Epub 2019 Jan 23.

Department of Physical Therapy, College of Healthcare Medical Science & Engineering, Inje University, Gimhae 50834, Korea.

We investigated the effects of environmental lighting conditions regulating endogenous melatonin production on neural repair, following experimental spinal cord injury (SCI). Rats were divided into three groups randomly: the SCI + L/D (12/12-h light/dark), SCI + LL (24-h constant light), and SCI + DD (24-h constant dark) groups. Controlled light/dark cycle was pre-applied 2 weeks before induction of spinal cord injury. Read More

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http://dx.doi.org/10.3390/jcm8020135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406284PMC
January 2019

Tensiomyography detects early hallmarks of bed-rest-induced atrophy before changes in muscle architecture.

J Appl Physiol (1985) 2019 Apr 24;126(4):815-822. Epub 2019 Jan 24.

School of Healthcare Science, Manchester Metropolitan University , Manchester , United Kingdom.

In young and older people, skeletal muscle mass is reduced after as little as 7 days of disuse. The declines in muscle mass after such short periods are of high clinical relevance, particularly in older people who show a higher atrophy rate and a slower or even a complete lack of muscle mass recovery after disuse. Ten men (24. Read More

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https://www.physiology.org/doi/10.1152/japplphysiol.00880.20
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http://dx.doi.org/10.1152/japplphysiol.00880.2018DOI Listing
April 2019
27 Reads

Myokines in Home-Based Functional Electrical Stimulation-Induced Recovery of Skeletal Muscle in Elderly and Permanent Denervation.

Eur J Transl Myol 2018 Nov 16;28(4):7905. Epub 2018 Nov 16.

Istituto di Istologia ed Embriologia, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Neuromuscular disorders, disuse, inadequate nutrition, metabolic diseases, cancer and aging produce muscle atrophy and this implies that there are different types of molecular triggers and signaling pathways for muscle wasting. Exercise and muscle contractions may counteract muscle atrophy by releasing a group of peptides, termed myokines, to protect the functionality and to enhance the exercise capacity of skeletal muscle. In this review, we are looking at the role of myokines in the recovery of permanent denervated and elderly skeletal muscle tissue. Read More

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http://dx.doi.org/10.4081/ejtm.2018.7905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317133PMC
November 2018
3 Reads

Scaffold-facilitated locomotor improvement post complete spinal cord injury: Motor axon regeneration versus endogenous neuronal relay formation.

Biomaterials 2019 Mar 7;197:20-31. Epub 2019 Jan 7.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China. Electronic address:

Complete transected spinal cord injury (SCI) severely influences the quality of life and mortality rates of animals and patients. In the past decade, many simple and combinatorial therapeutic treatments have been tested in improving locomotor function in animals with this extraordinarily challenging SCI. The potential mechanism for promotion of locomotor function relies either on direct motor axon regeneration through the lesion gap or indirect neuronal relay bridging to functionally reconnect transected spinal stumps. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.012DOI Listing
March 2019
2 Reads
8.557 Impact Factor

The Differentiation of Spinal Cord Motor Neurons is Associated with Changes of the Mitochondrial Phospholipid Cardiolipin.

Neuroscience 2019 Feb 11;400:169-183. Epub 2019 Jan 11.

Department of Pathological Biochemistry, Medical Faculty, University of Magdeburg, Magdeburg, Germany.

Motor neuron damage caused by diseases, traumatic insults or de-afferentation of the spinal cord is often incurable due to the poor intrinsic regenerative capacity. Moreover, regenerated peripheral nerves often do not reach normal functionality. Here, we investigated cardiolipin in the process of neuro-differentiation, since cardiolipin is closely linked to the mitochondrial energy supply in cells. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2019.01.005DOI Listing
February 2019

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.

Authors:
Clotilde Théry Kenneth W Witwer Elena Aikawa Maria Jose Alcaraz Johnathon D Anderson Ramaroson Andriantsitohaina Anna Antoniou Tanina Arab Fabienne Archer Georgia K Atkin-Smith D Craig Ayre Jean-Marie Bach Daniel Bachurski Hossein Baharvand Leonora Balaj Shawn Baldacchino Natalie N Bauer Amy A Baxter Mary Bebawy Carla Beckham Apolonija Bedina Zavec Abderrahim Benmoussa Anna C Berardi Paolo Bergese Ewa Bielska Cherie Blenkiron Sylwia Bobis-Wozowicz Eric Boilard Wilfrid Boireau Antonella Bongiovanni Francesc E Borràs Steffi Bosch Chantal M Boulanger Xandra Breakefield Andrew M Breglio Meadhbh Á Brennan David R Brigstock Alain Brisson Marike Ld Broekman Jacqueline F Bromberg Paulina Bryl-Górecka Shilpa Buch Amy H Buck Dylan Burger Sara Busatto Dominik Buschmann Benedetta Bussolati Edit I Buzás James Bryan Byrd Giovanni Camussi David Rf Carter Sarah Caruso Lawrence W Chamley Yu-Ting Chang Chihchen Chen Shuai Chen Lesley Cheng Andrew R Chin Aled Clayton Stefano P Clerici Alex Cocks Emanuele Cocucci Robert J Coffey Anabela Cordeiro-da-Silva Yvonne Couch Frank Aw Coumans Beth Coyle Rossella Crescitelli Miria Ferreira Criado Crislyn D'Souza-Schorey Saumya Das Amrita Datta Chaudhuri Paola de Candia Eliezer F De Santana Olivier De Wever Hernando A Del Portillo Tanguy Demaret Sarah Deville Andrew Devitt Bert Dhondt Dolores Di Vizio Lothar C Dieterich Vincenza Dolo Ana Paula Dominguez Rubio Massimo Dominici Mauricio R Dourado Tom Ap Driedonks Filipe V Duarte Heather M Duncan Ramon M Eichenberger Karin Ekström Samir El Andaloussi Celine Elie-Caille Uta Erdbrügger Juan M Falcón-Pérez Farah Fatima Jason E Fish Miguel Flores-Bellver András Försönits Annie Frelet-Barrand Fabia Fricke Gregor Fuhrmann Susanne Gabrielsson Ana Gámez-Valero Chris Gardiner Kathrin Gärtner Raphael Gaudin Yong Song Gho Bernd Giebel Caroline Gilbert Mario Gimona Ilaria Giusti Deborah Ci Goberdhan André Görgens Sharon M Gorski David W Greening Julia Christina Gross Alice Gualerzi Gopal N Gupta Dakota Gustafson Aase Handberg Reka A Haraszti Paul Harrison Hargita Hegyesi An Hendrix Andrew F Hill Fred H Hochberg Karl F Hoffmann Beth Holder Harry Holthofer Baharak Hosseinkhani Guoku Hu Yiyao Huang Veronica Huber Stuart Hunt Ahmed Gamal-Eldin Ibrahim Tsuneya Ikezu Jameel M Inal Mustafa Isin Alena Ivanova Hannah K Jackson Soren Jacobsen Steven M Jay Muthuvel Jayachandran Guido Jenster Lanzhou Jiang Suzanne M Johnson Jennifer C Jones Ambrose Jong Tijana Jovanovic-Talisman Stephanie Jung Raghu Kalluri Shin-Ichi Kano Sukhbir Kaur Yumi Kawamura Evan T Keller Delaram Khamari Elena Khomyakova Anastasia Khvorova Peter Kierulf Kwang Pyo Kim Thomas Kislinger Mikael Klingeborn David J Klinke Miroslaw Kornek Maja M Kosanović Árpád Ferenc Kovács Eva-Maria Krämer-Albers Susanne Krasemann Mirja Krause Igor V Kurochkin Gina D Kusuma Sören Kuypers Saara Laitinen Scott M Langevin Lucia R Languino Joanne Lannigan Cecilia Lässer Louise C Laurent Gregory Lavieu Elisa Lázaro-Ibáñez Soazig Le Lay Myung-Shin Lee Yi Xin Fiona Lee Debora S Lemos Metka Lenassi Aleksandra Leszczynska Isaac Ts Li Ke Liao Sten F Libregts Erzsebet Ligeti Rebecca Lim Sai Kiang Lim Aija Linē Karen Linnemannstöns Alicia Llorente Catherine A Lombard Magdalena J Lorenowicz Ákos M Lörincz Jan Lötvall Jason Lovett Michelle C Lowry Xavier Loyer Quan Lu Barbara Lukomska Taral R Lunavat Sybren Ln Maas Harmeet Malhi Antonio Marcilla Jacopo Mariani Javier Mariscal Elena S Martens-Uzunova Lorena Martin-Jaular M Carmen Martinez Vilma Regina Martins Mathilde Mathieu Suresh Mathivanan Marco Maugeri Lynda K McGinnis Mark J McVey David G Meckes Katie L Meehan Inge Mertens Valentina R Minciacchi Andreas Möller Malene Møller Jørgensen Aizea Morales-Kastresana Jess Morhayim François Mullier Maurizio Muraca Luca Musante Veronika Mussack Dillon C Muth Kathryn H Myburgh Tanbir Najrana Muhammad Nawaz Irina Nazarenko Peter Nejsum Christian Neri Tommaso Neri Rienk Nieuwland Leonardo Nimrichter John P Nolan Esther Nm Nolte-'t Hoen Nicole Noren Hooten Lorraine O'Driscoll Tina O'Grady Ana O'Loghlen Takahiro Ochiya Martin Olivier Alberto Ortiz Luis A Ortiz Xabier Osteikoetxea Ole Østergaard Matias Ostrowski Jaesung Park D Michiel Pegtel Hector Peinado Francesca Perut Michael W Pfaffl Donald G Phinney Bartijn Ch Pieters Ryan C Pink David S Pisetsky Elke Pogge von Strandmann Iva Polakovicova Ivan Kh Poon Bonita H Powell Ilaria Prada Lynn Pulliam Peter Quesenberry Annalisa Radeghieri Robert L Raffai Stefania Raimondo Janusz Rak Marcel I Ramirez Graça Raposo Morsi S Rayyan Neta Regev-Rudzki Franz L Ricklefs Paul D Robbins David D Roberts Silvia C Rodrigues Eva Rohde Sophie Rome Kasper Ma Rouschop Aurelia Rughetti Ashley E Russell Paula Saá Susmita Sahoo Edison Salas-Huenuleo Catherine Sánchez Julie A Saugstad Meike J Saul Raymond M Schiffelers Raphael Schneider Tine Hiorth Schøyen Aaron Scott Eriomina Shahaj Shivani Sharma Olga Shatnyeva Faezeh Shekari Ganesh Vilas Shelke Ashok K Shetty Kiyotaka Shiba Pia R-M Siljander Andreia M Silva Agata Skowronek Orman L Snyder Rodrigo Pedro Soares Barbara W Sódar Carolina Soekmadji Javier Sotillo Philip D Stahl Willem Stoorvogel Shannon L Stott Erwin F Strasser Simon Swift Hidetoshi Tahara Muneesh Tewari Kate Timms Swasti Tiwari Rochelle Tixeira Mercedes Tkach Wei Seong Toh Richard Tomasini Ana Claudia Torrecilhas Juan Pablo Tosar Vasilis Toxavidis Lorena Urbanelli Pieter Vader Bas Wm van Balkom Susanne G van der Grein Jan Van Deun Martijn Jc van Herwijnen Kendall Van Keuren-Jensen Guillaume van Niel Martin E van Royen Andre J van Wijnen M Helena Vasconcelos Ivan J Vechetti Tiago D Veit Laura J Vella Émilie Velot Frederik J Verweij Beate Vestad Jose L Viñas Tamás Visnovitz Krisztina V Vukman Jessica Wahlgren Dionysios C Watson Marca Hm Wauben Alissa Weaver Jason P Webber Viktoria Weber Ann M Wehman Daniel J Weiss Joshua A Welsh Sebastian Wendt Asa M Wheelock Zoltán Wiener Leonie Witte Joy Wolfram Angeliki Xagorari Patricia Xander Jing Xu Xiaomei Yan María Yáñez-Mó Hang Yin Yuana Yuana Valentina Zappulli Jana Zarubova Vytautas Žėkas Jian-Ye Zhang Zezhou Zhao Lei Zheng Alexander R Zheutlin Antje M Zickler Pascale Zimmermann Angela M Zivkovic Davide Zocco Ewa K Zuba-Surma

J Extracell Vesicles 2018 23;7(1):1535750. Epub 2018 Nov 23.

Jagiellonian University, Faculty of Biochemistry, Biophysics and Biotechnology, Department of Cell Biology, Kraków, Poland.

The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles ("MISEV") guidelines for the field in 2014. Read More

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https://www.tandfonline.com/doi/full/10.1080/20013078.2018.1
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http://dx.doi.org/10.1080/20013078.2018.1535750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322352PMC
November 2018
54 Reads

Associations between leisure time physical activity and cardiovascular risk factors among older adults with long-term spinal cord injury.

Spinal Cord 2019 Jan 8. Epub 2019 Jan 8.

Department of Health Sciences, Lund University, Lund, Sweden.

Study Design: This is a cross-sectional study.

Objectives: To describe the association between cardiovascular risk factors (body mass index (BMI), waist circumference (WC), blood pressure, blood glucose and lipids) and leisure time physical activity (LTPA) in older adults with long-term spinal cord injury (SCI).

Setting: Community settings, southern Sweden. Read More

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http://www.nature.com/articles/s41393-018-0233-5
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http://dx.doi.org/10.1038/s41393-018-0233-5DOI Listing
January 2019
7 Reads

Deletion Promotes Recovery From Spinal Cord Injury by Neuroprotection and Reduces Macrophage/Microglia Proliferation.

Front Neurol 2018 13;9:1059. Epub 2018 Dec 13.

Department of Orthopaedics, The Affiliated Southeast Hospital of Xiamen University, Orthopaedic Center of People's Liberation Army, Zhangzhou, China.

Sorting nexin 27 (SNX27) is an endosome-associated cargo adaptor that is involved in various pathologies and development of neurological diseases. However, the role of SNX27 in spinal cord injury (SCI) remains unclear. In this study, we found that SNX27 was up-regulated in injured mice spinal cords by western blot and immunofluorescence. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2018.01059
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http://dx.doi.org/10.3389/fneur.2018.01059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300502PMC
December 2018
9 Reads

Manganese-Enhanced Magnetic Resonance Imaging: Overview and Central Nervous System Applications With a Focus on Neurodegeneration.

Front Aging Neurosci 2018 13;10:403. Epub 2018 Dec 13.

Department of Physiology, University of Kentucky, Lexington, KY, United States.

Manganese-enhanced magnetic resonance imaging (MEMRI) rose to prominence in the 1990s as a sensitive approach to high contrast imaging. Following the discovery of manganese conductance through calcium-permeable channels, MEMRI applications expanded to include functional imaging in the central nervous system (CNS) and other body systems. MEMRI has since been employed in the investigation of physiology in many animal models and in humans. Read More

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https://www.frontiersin.org/article/10.3389/fnagi.2018.00403
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http://dx.doi.org/10.3389/fnagi.2018.00403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300587PMC
December 2018
10 Reads

Neuroplastic Changes in Older Adults Performing Cooperative Hand Movements.

Front Hum Neurosci 2018 13;12:488. Epub 2018 Dec 13.

Spinal Cord Injury Center, Balgrist University Hospital, Zürich, Switzerland.

The aim of this study was to examine whether older adults use the same task-specific brain activation patterns during two different bimanual hand movement tasks as younger adults. Functional magnetic resonance brain imaging was performed in 18 younger (mean age: 30.3 ± 3. Read More

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http://dx.doi.org/10.3389/fnhum.2018.00488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300783PMC
December 2018

Individual variations of the human corticospinal tract and its hand-related motor fibers using diffusion MRI tractography.

Brain Imaging Behav 2019 Jan 8. Epub 2019 Jan 8.

Department of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

The corticospinal tract (CST) is one of the most well studied tracts in human neuroanatomy. Its clinical significance can be demonstrated in many notable traumatic conditions and diseases such as stroke, spinal cord injury (SCI) or amyotrophic lateral sclerosis (ALS). With the advent of diffusion MRI and tractography the computational representation of the human CST in a 3D model became available. Read More

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http://link.springer.com/10.1007/s11682-018-0006-y
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http://dx.doi.org/10.1007/s11682-018-0006-yDOI Listing
January 2019
4 Reads

The Role of Nocturnal Penile Tumescence and Rigidity (NPTR) Monitoring in the Diagnosis of Psychogenic Erectile Dysfunction: A Review.

Sex Med Rev 2019 Jan 3. Epub 2019 Jan 3.

Division of Urology, Department of Surgery, University of Texas McGovern Medical School at Houston, Houston, Texas, USA; University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Electronic address:

Introduction: Nocturnal penile tumescence and rigidity (NPTR) monitoring with RigiScan was considered one of the most reliable methods to differentiate psychogenic erectile dysfunction (pED) from organic ED. However, its reliability has been questioned because of some limitations in the practice.

Aim: To present contemporary views on the role of NPTR monitoring in the diagnosis of pED. Read More

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http://dx.doi.org/10.1016/j.sxmr.2018.10.005DOI Listing
January 2019
3 Reads

Time is spine: a review of translational advances in spinal cord injury.

J Neurosurg Spine 2018 Dec;30(1):1-18

1Division of Neurosurgery, Department of Surgery, and.

Acute traumatic spinal cord injury (SCI) is a devastating event with far-reaching physical, emotional, and economic consequences for patients, families, and society at large. Timely delivery of specialized care has reduced mortality; however, long-term neurological recovery continues to be limited. In recent years, a number of exciting neuroprotective and regenerative strategies have emerged and have come under active investigation in clinical trials, and several more are coming down the translational pipeline. Read More

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http://dx.doi.org/10.3171/2018.9.SPINE18682DOI Listing
December 2018
5 Reads

The IASP classification of chronic pain for ICD-11: chronic neuropathic pain.

Pain 2019 Jan;160(1):53-59

Department of Neurophysiology, CBTM, Medical Faculty Mannheim of Heidelberg University, Mannheim, Germany.

The upcoming 11th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD) of the World Health Organization (WHO) offers a unique opportunity to improve the representation of painful disorders. For this purpose, the International Association for the Study of Pain (IASP) has convened an interdisciplinary task force of pain specialists. Here, we present the case for a reclassification of nervous system lesions or diseases associated with persistent or recurrent pain for ≥3 months. Read More

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http://Insights.ovid.com/crossref?an=00006396-201901000-0000
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http://dx.doi.org/10.1097/j.pain.0000000000001365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310153PMC
January 2019
22 Reads
5.213 Impact Factor

Ageing, Disability, and Spinal Cord Injury: Some Issues of Analysis.

Curr Gerontol Geriatr Res 2018 19;2018:4017858. Epub 2018 Nov 19.

Department of Education Psychology and Philosophy, State University of Cagliari, Italy.

Spinal cord injury is a disabling disorder, worldwide spread, with important consequences on functioning and health conditions and impacts on physical, psychological, and social well-being. The consequences are related to the lesion itself and to other complications related to the lesion. In the last decades, there have been an increasing of the mean ages of onset and also an increase in life expectancy after the lesion. Read More

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https://www.hindawi.com/journals/cggr/2018/4017858/
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http://dx.doi.org/10.1155/2018/4017858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276527PMC
November 2018
14 Reads

Mitochondrial health and muscle plasticity after spinal cord injury.

Eur J Appl Physiol 2019 Feb 11;119(2):315-331. Epub 2018 Dec 11.

James J. Peters VA Medical Center, Bronx, NY, USA.

Mitochondria are responsible for aerobic respiration and large-scale ATP production in almost all cells of the body. Their function is decreased in many neurodegenerative and cardiovascular disease states, in metabolic disorders such as type II diabetes and obesity, and as a normal component of aging. Disuse of skeletal muscle from immobilization or unloading triggers alterations of mitochondrial density and activity. Read More

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http://link.springer.com/10.1007/s00421-018-4039-0
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http://dx.doi.org/10.1007/s00421-018-4039-0DOI Listing
February 2019
23 Reads

Chronic Intermittent Hypoxia Induces Robust Astrogliosis in an Alzheimer's Disease-Relevant Mouse Model.

Neuroscience 2019 02 7;398:55-63. Epub 2018 Dec 7.

Spinal Cord & Brain Injury Research Center, University of Kentucky, Lexington, KY, United States; Department of Neuroscience, University of Kentucky, Lexington, KY, United States. Electronic address:

Sleep disturbances are a common early symptom of neurodegenerative diseases, including Alzheimer's disease (AD) and other age-related dementias, and emerging evidence suggests that poor sleep may be an important contributor to development of amyloid pathology. Of the causes of sleep disturbances, it is estimated that 10-20% of adults in the United States have sleep-disordered breathing (SDB) disorder, with obstructive sleep apnea accounting for the majority of the SBD cases. The clinical and epidemiological data clearly support a link between sleep apnea and AD; yet, almost no experimental research is available exploring the mechanisms associated with this correlative link. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2018.11.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402802PMC
February 2019
1 Read

Biomaterials and Gene Manipulation in Stem Cell-Based Therapies for Spinal Cord Injury.

Stem Cells Dev 2019 Feb 28;28(4):239-257. Epub 2019 Jan 28.

1 Regenerative Medicine Center, the First Affiliated Hospital of Dalian Medical University, Dalian, China.

Spinal cord injury (SCI), a prominent health issue, represents a substantial portion of the global health care burden. Stem cell-based therapies provide novel solutions for SCI treatment, yet obstacles remain in the form of low survival rate, uncontrolled differentiation, and functional recovery. The application of engineered biomaterials in stem cell therapy provides a physicochemical microenvironment that mimics the stem cell niche, facilitating self-renewal, stem cell differentiation, and tissue reorganization. Read More

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http://dx.doi.org/10.1089/scd.2018.0169DOI Listing
February 2019
3 Reads

Spinal Cord Injury From Spinal Tumors: Prevalence, Management, and Outcomes.

World Neurosurg 2019 Feb 22;122:e1551-e1556. Epub 2018 Nov 22.

Department of Orthopaedic Surgery, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA. Electronic address:

Background: With the aging population in the United States, it can be anticipated that the prevalence of spinal cord injuries (SCIs) and cancer will increase. Primary or metastatic spine tumors sit at a unique intersection of these 2 realms. Our objective was to evaluate the prevalence, outcomes, and complications after the management of SCI arising from spinal tumors. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.11.099DOI Listing
February 2019
2 Reads

Reducing age-dependent monocyte-derived macrophage activation contributes to the therapeutic efficacy of NADPH oxidase inhibition in spinal cord injury.

Brain Behav Immun 2019 Feb 16;76:139-150. Epub 2018 Nov 16.

Spinal Cord and Brain Injury Research Center (SCoBIRC), Department of Physiology, University of Kentucky, Lexington, KY 40536, United States. Electronic address:

Objective: The average age at the time of spinal cord injury (SCI) has increased to 43 years old. Middle-aged mice (14 months old, MO) exhibit impaired recovery after SCI with age-dependent increases in reactive oxygen species (ROS) production through NADPH oxidase (NOX) along with pro-inflammatory macrophage activation. Despite these aging differences, clinical therapies are being examined in individuals regardless of age based upon preclinical data generated primarily using young animals (∼4 MO). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08891591183034
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http://dx.doi.org/10.1016/j.bbi.2018.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348135PMC
February 2019
10 Reads
5.889 Impact Factor

Efficacy of leukemia inhibitory factor as a therapeutic for permanent large vessel stroke differs among aged male and female rats.

Brain Res 2019 Mar 13;1707:62-73. Epub 2018 Nov 13.

Department of Neurology, University of Kentucky, 741 S. Limestone, Lexington, KY 40536, United States; Department of Neuroscience, University of Kentucky, 800 Rose St., Lexington, KY 40536, United States. Electronic address:

Preclinical studies using rodent models of stroke have had difficulty in translating their results to human patients. One possible factor behind this inability is the lack of studies utilizing aged rodents of both sexes. Previously, this lab showed that leukemia inhibitory factor (LIF) promoted recovery after stroke through antioxidant enzyme upregulation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00068993183057
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http://dx.doi.org/10.1016/j.brainres.2018.11.017DOI Listing
March 2019
11 Reads

Motor Recovery after Chronic Spinal Cord Transection in Rats: A Proof-of-Concept Study Evaluating a Combined Strategy.

CNS Neurol Disord Drug Targets 2019 ;18(1):52-62

Centro de Investigacion en Ciencias de la Salud (CICSA), Universidad Anahuac Mexico Campus Norte, Huixquilucan Estado de Mexico, Mexico.

Background: The chronic phase of Spinal Cord (SC) injury is characterized by the presence of a hostile microenvironment that causes low activity and a progressive decline in neurological function; this phase is non-compatible with regeneration. Several treatment strategies have been investigated in chronic SC injury with no satisfactory results. OBJECTIVE- In this proof-of-concept study, we designed a combination therapy (Comb Tx) consisting of surgical glial scar removal plus scar inhibition, accompanied with implantation of mesenchymal stem cells (MSC), and immunization with neural-derived peptides (INDP). Read More

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http://dx.doi.org/10.2174/1871527317666181105101756DOI Listing
January 2019
15 Reads

Aging Is Associated With Impaired Activation of Protein Homeostasis-Related Pathways After Cardiac Arrest in Mice.

J Am Heart Assoc 2018 Sep;7(17):e009634

1 Center for Perioperative Organ Protection Department of Anesthesiology Duke University Medical Center Durham NC.

Background The mechanisms underlying worse outcome at advanced age after cardiac arrest ( CA ) and resuscitation are not well understood. Because protein homeostasis (proteostasis) is essential for cellular and organismal health, but is impaired after CA , we investigated the effects of age on proteostasis-related prosurvival pathways activated after CA . Methods and Results Young (2-3 months old) and aged (21-22 months old) male C57Bl/6 mice were subjected to CA and cardiopulmonary resuscitation ( CPR ). Read More

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https://www.ahajournals.org/doi/10.1161/JAHA.118.009634
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http://dx.doi.org/10.1161/JAHA.118.009634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201440PMC
September 2018
10 Reads
2.880 Impact Factor

A Valid and Precise Semiautomated Method for Quantifying INTERmuscular Fat INTRAmuscular Fat in Lower Leg Magnetic Resonance Images.

J Clin Densitom 2018 Sep 22. Epub 2018 Sep 22.

University Health Network, Osteoporosis Program, Toronto General Research Institute, Toronto, Ontario, Canada.

The accumulation of INTERmuscular fat and INTRAmuscular fat (IMF) has been a hallmark of individuals with diabetes, those with mobility impairments such as spinal cord injuries and is known to increase with aging. An elevated amount of IMF has been associated with fractures and frailty, but the imprecision of IMF measurement has so far limited the ability to observe more consistent clinical associations. Magnetic resonance imaging has been recognized as the gold standard for portraying these features, yet reliable methods for quantifying IMF on magnetic resonance imaging is far from standardized. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10946950183013
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http://dx.doi.org/10.1016/j.jocd.2018.09.007DOI Listing
September 2018
15 Reads

Cardiorespiratory fitness and arm bone mineral health in young males with spinal cord injury: the mediator role of lean mass.

J Sports Sci 2019 Apr 13;37(7):717-725. Epub 2018 Oct 13.

a GENUD Toledo Research Group , Universidad de Castilla-La Mancha , Toledo , Spain.

Spinal cord injury (SCI) derives in loss of bone mineral content (BMC) and bone mineral density (BMD). However, physical activity is an important determinant in bone mass acquisition, which is partially mediated through the lean mass (LM). The aim was to examine the effect of cardiorespiratory fitness (CRF) on BMD and BMC arms of adult males with SCI and able-bodied controls using the arm LM as a mediator variable. Read More

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https://www.tandfonline.com/doi/full/10.1080/02640414.2018.1
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http://dx.doi.org/10.1080/02640414.2018.1522948DOI Listing
April 2019
10 Reads

Changes in perceived social support predict changes in depressive symptoms in adults with physical disability.

Disabil Health J 2019 04 5;12(2):214-219. Epub 2018 Oct 5.

Department of Rehabilitation Medicine, University of Washington, Harborview Medical Center, Box 359612, 325 Ninth Avenue, Seattle, WA, 98104-2499, USA.

Background: Perceived social support has been found to be associated with depression, subjective well-being and psychological health in cross-sectional studies in people with physical disabilities. No longitudinal studies have been conducted to examine these associations over time using a comprehensive measure of social support.

Objective/hypothesis: We hypothesized that: (1) the amount of perceived social support would be similar across individuals with different diagnoses often associated with disability (i. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19366574183019
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http://dx.doi.org/10.1016/j.dhjo.2018.09.005DOI Listing
April 2019
1 Read

Chronic Traumatic Encephalopathy Within an Amyotrophic Lateral Sclerosis Brain Bank Cohort.

J Neuropathol Exp Neurol 2018 Dec;77(12):1091-1100

VA Boston Healthcare System, Boston, Massachusetts.

Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disorder linked to repetitive head impacts and has been associated with amyotrophic lateral sclerosis (ALS), a fatal, degenerative neuromuscular disorder. The Department of Veterans Affairs Biorepository Brain Bank (VABBB) is a tissue repository that collects antemortem disease progression data and postmortem central nervous system tissue from veterans with ALS. We set out to determine the frequency of co-morbid ALS and CTE in the VABBB cohort and to characterize the clinical, genetic, and pathological distinctions between participants with ALS only and those with both ALS and CTE (ALS+CTE). Read More

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https://academic.oup.com/jnen/article/77/12/1091/5123933
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http://dx.doi.org/10.1093/jnen/nly092DOI Listing
December 2018
27 Reads

Sex/gender disparities in health outcomes of individuals with long-term disabling conditions.

Rehabil Psychol 2019 May 8;64(2):221-228. Epub 2018 Oct 8.

Department of Rehabilitation Medicine.

Background: Women with disabling conditions experience health disparities relative to nondisabled women, but few studies have compared women and men with disabling conditions.

Objectives: To investigate gender differences in physical functioning and emotional health among individuals with long-term disabling conditions, that is, neuromuscular disease, multiple sclerosis, postpolio syndrome, or spinal cord injury.

Method: From a mailed survey of 1,862 adults with long-term disabling conditions, we used the 12-item Patient-Reported Outcomes Measurement Information System (PROMIS) physical functioning to assess physical limitations in activities and Patient Health Questionnaire-9 (PHQ-9) for emotional health and severity of secondary conditions (rated 0-10). Read More

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http://doi.apa.org/getdoi.cfm?doi=10.1037/rep0000248
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http://dx.doi.org/10.1037/rep0000248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453755PMC
May 2019
12 Reads

Age Influences Microglial Activation After Cuprizone-Induced Demyelination.

Front Aging Neurosci 2018 20;10:278. Epub 2018 Sep 20.

Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria.

Multiple sclerosis (MS) is a chronic inflammatory CNS disease, which causes demyelinated lesions and damages white and gray matter regions. Aging is a significant factor in the progression of MS, and microglia, the immune cells of the CNS tissue, play an important role in all disease stages. During aging, microglia are functionally altered. Read More

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https://www.frontiersin.org/article/10.3389/fnagi.2018.00278
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http://dx.doi.org/10.3389/fnagi.2018.00278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160739PMC
September 2018
5 Reads

Aging alters glucose uptake in the naïve and injured rodent spinal cord.

Neurosci Lett 2019 01 6;690:23-28. Epub 2018 Oct 6.

Neuroscience Program, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA; Department of Anatomy, Physiology, and Genetics, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA; Center for Neuroscience and Regenerative Medicine, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD, USA. Electronic address:

Aging results in increased activation of inflammatory glial cells and decreased neuronal viability following spinal cord injury (SCI). Metabolism and transport of glucose is also decreased with age, although the influence of age on glucose transporter (GLUT) expression or glucose uptake in SCI is currently unknown. We therefore performed [F]Fluorodeoxyglucose (FDG) PET imaging of young (3 month) and middle-aged (12 month) rats. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03043940183067
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http://dx.doi.org/10.1016/j.neulet.2018.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320289PMC
January 2019
3 Reads

Replication and novel analysis of age and sex effects on the neurologic and functional value of each spinal segment in the US healthcare setting.

Spinal Cord 2019 Feb 5;57(2):156-164. Epub 2018 Oct 5.

Department of Physical Medicine and Rehabilitation, MetroHealth Medical Center, Institute for Functional Restoration, Case Western Reserve University, Cleveland, OH, USA.

Study Design: Replication of previously developed prognostic model.

Objectives: In motor complete injuries at admission to rehabilitation, perform; (1) replication analyses of the relationships between ISNCSCI motor level and motor scores and SCIM and (2) novel analyses to determine if age and/or sex moderate relationship between neurological impairment and function.

Setting: Admission to initial inpatient rehabilitation in the United States. Read More

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http://www.nature.com/articles/s41393-018-0206-8
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http://dx.doi.org/10.1038/s41393-018-0206-8DOI Listing
February 2019
10 Reads

Adult spinal motoneurons change their neurotransmitter phenotype to control locomotion.

Proc Natl Acad Sci U S A 2018 10 1;115(42):E9926-E9933. Epub 2018 Oct 1.

Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden

A particularly essential determinant of a neuron's functionality is its neurotransmitter phenotype. While the prevailing view is that neurotransmitter phenotypes are fixed and determined early during development, a growing body of evidence suggests that neurons retain the ability to switch between different neurotransmitters. However, such changes are considered unlikely in motoneurons due to their crucial functional role in animals' behavior. Read More

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http://www.pnas.org/lookup/doi/10.1073/pnas.1809050115
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http://dx.doi.org/10.1073/pnas.1809050115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196516PMC
October 2018
17 Reads

Magnitude of dural tube compression does not show a predictive value for symptomatic lumbar spinal stenosis for 1-year follow-up: a prospective cohort study in the community.

Clin Interv Aging 2018 13;13:1739-1746. Epub 2018 Sep 13.

Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan,

Background: The North American Spine Society states that lumbar spinal stenosis (LSS) is a clinical syndrome, and there is insufficient evidence to make a recommendation for or against a correlation between clinical symptoms or function and the presence of anatomic narrowing of the spinal canal on MRI. The main purpose of this study was to assess the influence of the magnitude of dural tube compression on MRI on LSS symptoms at the cross-sectional and 1-year follow-up.

Methods: This was a prospective cohort study of 459 participants who were assessed for LSS using a questionnaire and conventional MRI of the lumbar spine. Read More

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https://www.dovepress.com/magnitude-of-dural-tube-compressio
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http://dx.doi.org/10.2147/CIA.S171049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145355PMC
December 2018
1 Read

Brainstem Imaging in Alzheimer's Disease: Potential for Biomarker Development.

Front Aging Neurosci 2018 11;10:266. Epub 2018 Sep 11.

Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, United States.

The dearth of effective treatments for Alzheimer's disease (AD) is one of the largest public health issues worldwide, costing hundreds of billions of dollars per year. From a therapeutic standpoint, research efforts to date have met with strikingly little clinical success. One major issue is that trials begin after substantial pathological change has occurred, and it is increasingly clear that the most effective treatment regimens will need to be administered earlier in the disease process. Read More

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http://dx.doi.org/10.3389/fnagi.2018.00266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141632PMC
September 2018
14 Reads

Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease.

Neurobiol Aging 2018 Dec 9;72:188.e3-188.e12. Epub 2018 Aug 9.

Medical Genomics Research Unit, GIGA-R, University of Liège, Belgium; Walloon Excellence in Life sciences and BIOtechnology (WELBIO), Belgium; Department of Human Genetics, KU Leuven, Leuven, Belgium.

Systematic epistasis analyses in multifactorial disorders are an important step to better characterize complex genetic risk structures. We conducted a hypothesis-free sex-stratified genome-wide screening for epistasis contributing to Alzheimer's disease (AD) susceptibility. We identified a statistical epistasis signal between the single nucleotide polymorphisms rs3733980 and rs7175766 that was associated with AD in males (genome-wide significant p=0. Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.08.001DOI Listing
December 2018
6 Reads

Epidemiological Features of Spinal Cord Injury in China: A Systematic Review.

Front Neurol 2018 22;9:683. Epub 2018 Aug 22.

Department of Orthopaedics, Tianjin Medical University General Hospital, Tianjin, China.

Spinal cord injury (SCI) is a severe condition that disrupts patients' physiological, mental, and social well-being state and exerts great financial burden on patients, their families and social healthcare system. This review intends to compile studies regarding epidemiological features of SCI in China. Searches were conducted on PubMed, EMBASE, Web of Science and Cochrane Library for relevant studies published through January, 2018. Read More

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http://dx.doi.org/10.3389/fneur.2018.00683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113592PMC
August 2018
2 Reads