919 results match your criteria Spinal Cord Injury and Aging


Use of a combination strategy to improve neuroprotection and neuroregeneration in a rat model of acute spinal cord injury.

Neural Regen Res 2019 Jun;14(6):1060-1068

Centro de Investigación en Ciencias de la Salud (CICSA), Facultad de Ciencias de la Salud, Universidad Anáhuac México Campus Norte, Huixquilucan, Edo. de México, México; Centro de Investigación del Proyecto CAMINA A.C.; Ciudad de México, México.

Spinal cord injury is a very common pathological event that has devastating functional consequences in patients. In recent years, several research groups are trying to find an effective therapy that could be applied in clinical practice. In this study, we analyzed the combination of different strategies as a potential therapy for spinal cord injury. Read More

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http://dx.doi.org/10.4103/1673-5374.250627DOI Listing

Tau drives translational selectivity by interacting with ribosomal proteins.

Acta Neuropathol 2019 Feb 13. Epub 2019 Feb 13.

Department of Neuroscience and Center for Translational Research in Neurodegenerative Disease, University of Florida, 1275 Center Drive, BOX 100159, Gainesville, FL, 32610, USA.

There is a fundamental gap in understanding the consequences of tau-ribosome interactions. Tau oligomers and filaments hinder protein synthesis in vitro, and they associate strongly with ribosomes in vivo. Here, we investigated the consequences of tau interactions with ribosomes in transgenic mice, in cells, and in human brain tissues to identify tau as a direct modulator of ribosomal selectivity. Read More

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http://dx.doi.org/10.1007/s00401-019-01970-9DOI Listing
February 2019

An epidemiological study of traumatic spinal cord injuries in the fastest aging area in Japan.

Spinal Cord 2019 Feb 7. Epub 2019 Feb 7.

Department of Orthopedic Surgery, Akita Red Cross Hospital, Akita, Japan.

Study Design: Retrospective epidemiological study.

Objective: To investigate the epidemiology of traumatic spinal cord injury (TSCI) in the fastest aging area in Japan.

Setting: Hospitals in Akita Prefecture, Japan. Read More

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http://dx.doi.org/10.1038/s41393-019-0255-7DOI Listing
February 2019

C7 transfer in a posterior intradural approach for treating hemiplegic upper-limbs: hypothesis and a cadaver feasibility study.

Br J Neurosurg 2019 Jan 25:1-5. Epub 2019 Jan 25.

a Department of Hand Surgery , Huashan Hospital, Shanghai Medical College, Fudan University , Shanghai , China.

Objective: Contralateral C7 nerve root transfer surgery has been successfully applied to rescue motor function of a hemiplegic upper extremity in patients with central neurological injury. This surgical technique is challenging, and limited anatomical space makes it difficult to manipulate tissues and may lead to higher complication rates. The authors hypothesis a new surgical route in which cervical nerve roots of both donor and recipient sides are exposed from a posterior intradural approach and neurorrhaphy is performed easily and clearly. Read More

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http://dx.doi.org/10.1080/02688697.2018.1552754DOI Listing
January 2019
2 Reads

Elevated Serum Melatonin under Constant Darkness Enhances Neural Repair in Spinal Cord Injury through Regulation of Circadian Clock Proteins Expression.

J Clin Med 2019 Jan 23;8(2). Epub 2019 Jan 23.

Department of Physical Therapy, College of Healthcare Medical Science & Engineering, Inje University, Gimhae 50834, Korea.

We investigated the effects of environmental lighting conditions regulating endogenous melatonin production on neural repair, following experimental spinal cord injury (SCI). Rats were divided into three groups randomly: the SCI + L/D (12/12-h light/dark), SCI + LL (24-h constant light), and SCI + DD (24-h constant dark) groups. Controlled light/dark cycle was pre-applied 2 weeks before induction of spinal cord injury. Read More

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http://dx.doi.org/10.3390/jcm8020135DOI Listing
January 2019

Myokines in Home-Based Functional Electrical Stimulation-Induced Recovery of Skeletal Muscle in Elderly and Permanent Denervation.

Eur J Transl Myol 2018 Nov 16;28(4):7905. Epub 2018 Nov 16.

Istituto di Istologia ed Embriologia, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Neuromuscular disorders, disuse, inadequate nutrition, metabolic diseases, cancer and aging produce muscle atrophy and this implies that there are different types of molecular triggers and signaling pathways for muscle wasting. Exercise and muscle contractions may counteract muscle atrophy by releasing a group of peptides, termed myokines, to protect the functionality and to enhance the exercise capacity of skeletal muscle. In this review, we are looking at the role of myokines in the recovery of permanent denervated and elderly skeletal muscle tissue. Read More

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http://dx.doi.org/10.4081/ejtm.2018.7905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317133PMC
November 2018
2 Reads

Scaffold-facilitated locomotor improvement post complete spinal cord injury: Motor axon regeneration versus endogenous neuronal relay formation.

Biomaterials 2019 Mar 7;197:20-31. Epub 2019 Jan 7.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China. Electronic address:

Complete transected spinal cord injury (SCI) severely influences the quality of life and mortality rates of animals and patients. In the past decade, many simple and combinatorial therapeutic treatments have been tested in improving locomotor function in animals with this extraordinarily challenging SCI. The potential mechanism for promotion of locomotor function relies either on direct motor axon regeneration through the lesion gap or indirect neuronal relay bridging to functionally reconnect transected spinal stumps. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.012DOI Listing
March 2019
1 Read
8.557 Impact Factor

The Differentiation of Spinal Cord Motor Neurons is Associated with Changes of the Mitochondrial Phospholipid Cardiolipin.

Neuroscience 2019 Feb 11;400:169-183. Epub 2019 Jan 11.

Department of Pathological Biochemistry, Medical Faculty, University of Magdeburg, Magdeburg, Germany.

Motor neuron damage caused by diseases, traumatic insults or de-afferentation of the spinal cord is often incurable due to the poor intrinsic regenerative capacity. Moreover, regenerated peripheral nerves often do not reach normal functionality. Here, we investigated cardiolipin in the process of neuro-differentiation, since cardiolipin is closely linked to the mitochondrial energy supply in cells. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2019.01.005DOI Listing
February 2019

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.

Authors:
Clotilde Théry Kenneth W Witwer Elena Aikawa Maria Jose Alcaraz Johnathon D Anderson Ramaroson Andriantsitohaina Anna Antoniou Tanina Arab Fabienne Archer Georgia K Atkin-Smith D Craig Ayre Jean-Marie Bach Daniel Bachurski Hossein Baharvand Leonora Balaj Shawn Baldacchino Natalie N Bauer Amy A Baxter Mary Bebawy Carla Beckham Apolonija Bedina Zavec Abderrahim Benmoussa Anna C Berardi Paolo Bergese Ewa Bielska Cherie Blenkiron Sylwia Bobis-Wozowicz Eric Boilard Wilfrid Boireau Antonella Bongiovanni Francesc E Borràs Steffi Bosch Chantal M Boulanger Xandra Breakefield Andrew M Breglio Meadhbh Á Brennan David R Brigstock Alain Brisson Marike Ld Broekman Jacqueline F Bromberg Paulina Bryl-Górecka Shilpa Buch Amy H Buck Dylan Burger Sara Busatto Dominik Buschmann Benedetta Bussolati Edit I Buzás James Bryan Byrd Giovanni Camussi David Rf Carter Sarah Caruso Lawrence W Chamley Yu-Ting Chang Chihchen Chen Shuai Chen Lesley Cheng Andrew R Chin Aled Clayton Stefano P Clerici Alex Cocks Emanuele Cocucci Robert J Coffey Anabela Cordeiro-da-Silva Yvonne Couch Frank Aw Coumans Beth Coyle Rossella Crescitelli Miria Ferreira Criado Crislyn D'Souza-Schorey Saumya Das Amrita Datta Chaudhuri Paola de Candia Eliezer F De Santana Olivier De Wever Hernando A Del Portillo Tanguy Demaret Sarah Deville Andrew Devitt Bert Dhondt Dolores Di Vizio Lothar C Dieterich Vincenza Dolo Ana Paula Dominguez Rubio Massimo Dominici Mauricio R Dourado Tom Ap Driedonks Filipe V Duarte Heather M Duncan Ramon M Eichenberger Karin Ekström Samir El Andaloussi Celine Elie-Caille Uta Erdbrügger Juan M Falcón-Pérez Farah Fatima Jason E Fish Miguel Flores-Bellver András Försönits Annie Frelet-Barrand Fabia Fricke Gregor Fuhrmann Susanne Gabrielsson Ana Gámez-Valero Chris Gardiner Kathrin Gärtner Raphael Gaudin Yong Song Gho Bernd Giebel Caroline Gilbert Mario Gimona Ilaria Giusti Deborah Ci Goberdhan André Görgens Sharon M Gorski David W Greening Julia Christina Gross Alice Gualerzi Gopal N Gupta Dakota Gustafson Aase Handberg Reka A Haraszti Paul Harrison Hargita Hegyesi An Hendrix Andrew F Hill Fred H Hochberg Karl F Hoffmann Beth Holder Harry Holthofer Baharak Hosseinkhani Guoku Hu Yiyao Huang Veronica Huber Stuart Hunt Ahmed Gamal-Eldin Ibrahim Tsuneya Ikezu Jameel M Inal Mustafa Isin Alena Ivanova Hannah K Jackson Soren Jacobsen Steven M Jay Muthuvel Jayachandran Guido Jenster Lanzhou Jiang Suzanne M Johnson Jennifer C Jones Ambrose Jong Tijana Jovanovic-Talisman Stephanie Jung Raghu Kalluri Shin-Ichi Kano Sukhbir Kaur Yumi Kawamura Evan T Keller Delaram Khamari Elena Khomyakova Anastasia Khvorova Peter Kierulf Kwang Pyo Kim Thomas Kislinger Mikael Klingeborn David J Klinke Miroslaw Kornek Maja M Kosanović Árpád Ferenc Kovács Eva-Maria Krämer-Albers Susanne Krasemann Mirja Krause Igor V Kurochkin Gina D Kusuma Sören Kuypers Saara Laitinen Scott M Langevin Lucia R Languino Joanne Lannigan Cecilia Lässer Louise C Laurent Gregory Lavieu Elisa Lázaro-Ibáñez Soazig Le Lay Myung-Shin Lee Yi Xin Fiona Lee Debora S Lemos Metka Lenassi Aleksandra Leszczynska Isaac Ts Li Ke Liao Sten F Libregts Erzsebet Ligeti Rebecca Lim Sai Kiang Lim Aija Linē Karen Linnemannstöns Alicia Llorente Catherine A Lombard Magdalena J Lorenowicz Ákos M Lörincz Jan Lötvall Jason Lovett Michelle C Lowry Xavier Loyer Quan Lu Barbara Lukomska Taral R Lunavat Sybren Ln Maas Harmeet Malhi Antonio Marcilla Jacopo Mariani Javier Mariscal Elena S Martens-Uzunova Lorena Martin-Jaular M Carmen Martinez Vilma Regina Martins Mathilde Mathieu Suresh Mathivanan Marco Maugeri Lynda K McGinnis Mark J McVey David G Meckes Katie L Meehan Inge Mertens Valentina R Minciacchi Andreas Möller Malene Møller Jørgensen Aizea Morales-Kastresana Jess Morhayim François Mullier Maurizio Muraca Luca Musante Veronika Mussack Dillon C Muth Kathryn H Myburgh Tanbir Najrana Muhammad Nawaz Irina Nazarenko Peter Nejsum Christian Neri Tommaso Neri Rienk Nieuwland Leonardo Nimrichter John P Nolan Esther Nm Nolte-'t Hoen Nicole Noren Hooten Lorraine O'Driscoll Tina O'Grady Ana O'Loghlen Takahiro Ochiya Martin Olivier Alberto Ortiz Luis A Ortiz Xabier Osteikoetxea Ole Østergaard Matias Ostrowski Jaesung Park D Michiel Pegtel Hector Peinado Francesca Perut Michael W Pfaffl Donald G Phinney Bartijn Ch Pieters Ryan C Pink David S Pisetsky Elke Pogge von Strandmann Iva Polakovicova Ivan Kh Poon Bonita H Powell Ilaria Prada Lynn Pulliam Peter Quesenberry Annalisa Radeghieri Robert L Raffai Stefania Raimondo Janusz Rak Marcel I Ramirez Graça Raposo Morsi S Rayyan Neta Regev-Rudzki Franz L Ricklefs Paul D Robbins David D Roberts Silvia C Rodrigues Eva Rohde Sophie Rome Kasper Ma Rouschop Aurelia Rughetti Ashley E Russell Paula Saá Susmita Sahoo Edison Salas-Huenuleo Catherine Sánchez Julie A Saugstad Meike J Saul Raymond M Schiffelers Raphael Schneider Tine Hiorth Schøyen Aaron Scott Eriomina Shahaj Shivani Sharma Olga Shatnyeva Faezeh Shekari Ganesh Vilas Shelke Ashok K Shetty Kiyotaka Shiba Pia R-M Siljander Andreia M Silva Agata Skowronek Orman L Snyder Rodrigo Pedro Soares Barbara W Sódar Carolina Soekmadji Javier Sotillo Philip D Stahl Willem Stoorvogel Shannon L Stott Erwin F Strasser Simon Swift Hidetoshi Tahara Muneesh Tewari Kate Timms Swasti Tiwari Rochelle Tixeira Mercedes Tkach Wei Seong Toh Richard Tomasini Ana Claudia Torrecilhas Juan Pablo Tosar Vasilis Toxavidis Lorena Urbanelli Pieter Vader Bas Wm van Balkom Susanne G van der Grein Jan Van Deun Martijn Jc van Herwijnen Kendall Van Keuren-Jensen Guillaume van Niel Martin E van Royen Andre J van Wijnen M Helena Vasconcelos Ivan J Vechetti Tiago D Veit Laura J Vella Émilie Velot Frederik J Verweij Beate Vestad Jose L Viñas Tamás Visnovitz Krisztina V Vukman Jessica Wahlgren Dionysios C Watson Marca Hm Wauben Alissa Weaver Jason P Webber Viktoria Weber Ann M Wehman Daniel J Weiss Joshua A Welsh Sebastian Wendt Asa M Wheelock Zoltán Wiener Leonie Witte Joy Wolfram Angeliki Xagorari Patricia Xander Jing Xu Xiaomei Yan María Yáñez-Mó Hang Yin Yuana Yuana Valentina Zappulli Jana Zarubova Vytautas Žėkas Jian-Ye Zhang Zezhou Zhao Lei Zheng Alexander R Zheutlin Antje M Zickler Pascale Zimmermann Angela M Zivkovic Davide Zocco Ewa K Zuba-Surma

J Extracell Vesicles 2018 23;7(1):1535750. Epub 2018 Nov 23.

Jagiellonian University, Faculty of Biochemistry, Biophysics and Biotechnology, Department of Cell Biology, Kraków, Poland.

The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles ("MISEV") guidelines for the field in 2014. Read More

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https://www.tandfonline.com/doi/full/10.1080/20013078.2018.1
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http://dx.doi.org/10.1080/20013078.2018.1535750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322352PMC
November 2018
27 Reads

Associations between leisure time physical activity and cardiovascular risk factors among older adults with long-term spinal cord injury.

Spinal Cord 2019 Jan 8. Epub 2019 Jan 8.

Department of Health Sciences, Lund University, Lund, Sweden.

Study Design: This is a cross-sectional study.

Objectives: To describe the association between cardiovascular risk factors (body mass index (BMI), waist circumference (WC), blood pressure, blood glucose and lipids) and leisure time physical activity (LTPA) in older adults with long-term spinal cord injury (SCI).

Setting: Community settings, southern Sweden. Read More

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http://www.nature.com/articles/s41393-018-0233-5
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http://dx.doi.org/10.1038/s41393-018-0233-5DOI Listing
January 2019
4 Reads

Deletion Promotes Recovery From Spinal Cord Injury by Neuroprotection and Reduces Macrophage/Microglia Proliferation.

Front Neurol 2018 13;9:1059. Epub 2018 Dec 13.

Department of Orthopaedics, The Affiliated Southeast Hospital of Xiamen University, Orthopaedic Center of People's Liberation Army, Zhangzhou, China.

Sorting nexin 27 (SNX27) is an endosome-associated cargo adaptor that is involved in various pathologies and development of neurological diseases. However, the role of SNX27 in spinal cord injury (SCI) remains unclear. In this study, we found that SNX27 was up-regulated in injured mice spinal cords by western blot and immunofluorescence. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2018.01059
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http://dx.doi.org/10.3389/fneur.2018.01059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300502PMC
December 2018
5 Reads

Manganese-Enhanced Magnetic Resonance Imaging: Overview and Central Nervous System Applications With a Focus on Neurodegeneration.

Front Aging Neurosci 2018 13;10:403. Epub 2018 Dec 13.

Department of Physiology, University of Kentucky, Lexington, KY, United States.

Manganese-enhanced magnetic resonance imaging (MEMRI) rose to prominence in the 1990s as a sensitive approach to high contrast imaging. Following the discovery of manganese conductance through calcium-permeable channels, MEMRI applications expanded to include functional imaging in the central nervous system (CNS) and other body systems. MEMRI has since been employed in the investigation of physiology in many animal models and in humans. Read More

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https://www.frontiersin.org/article/10.3389/fnagi.2018.00403
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http://dx.doi.org/10.3389/fnagi.2018.00403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300587PMC
December 2018
5 Reads

Neuroplastic Changes in Older Adults Performing Cooperative Hand Movements.

Front Hum Neurosci 2018 13;12:488. Epub 2018 Dec 13.

Spinal Cord Injury Center, Balgrist University Hospital, Zürich, Switzerland.

The aim of this study was to examine whether older adults use the same task-specific brain activation patterns during two different bimanual hand movement tasks as younger adults. Functional magnetic resonance brain imaging was performed in 18 younger (mean age: 30.3 ± 3. Read More

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http://dx.doi.org/10.3389/fnhum.2018.00488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300783PMC
December 2018

Individual variations of the human corticospinal tract and its hand-related motor fibers using diffusion MRI tractography.

Brain Imaging Behav 2019 Jan 8. Epub 2019 Jan 8.

Department of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

The corticospinal tract (CST) is one of the most well studied tracts in human neuroanatomy. Its clinical significance can be demonstrated in many notable traumatic conditions and diseases such as stroke, spinal cord injury (SCI) or amyotrophic lateral sclerosis (ALS). With the advent of diffusion MRI and tractography the computational representation of the human CST in a 3D model became available. Read More

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http://link.springer.com/10.1007/s11682-018-0006-y
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http://dx.doi.org/10.1007/s11682-018-0006-yDOI Listing
January 2019
2 Reads

The Role of Nocturnal Penile Tumescence and Rigidity (NPTR) Monitoring in the Diagnosis of Psychogenic Erectile Dysfunction: A Review.

Sex Med Rev 2019 Jan 3. Epub 2019 Jan 3.

Division of Urology, Department of Surgery, University of Texas McGovern Medical School at Houston, Houston, Texas, USA; University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Electronic address:

Introduction: Nocturnal penile tumescence and rigidity (NPTR) monitoring with RigiScan was considered one of the most reliable methods to differentiate psychogenic erectile dysfunction (pED) from organic ED. However, its reliability has been questioned because of some limitations in the practice.

Aim: To present contemporary views on the role of NPTR monitoring in the diagnosis of pED. Read More

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http://dx.doi.org/10.1016/j.sxmr.2018.10.005DOI Listing
January 2019
1 Read

Time is spine: a review of translational advances in spinal cord injury.

J Neurosurg Spine 2018 Dec;30(1):1-18

1Division of Neurosurgery, Department of Surgery, and.

Acute traumatic spinal cord injury (SCI) is a devastating event with far-reaching physical, emotional, and economic consequences for patients, families, and society at large. Timely delivery of specialized care has reduced mortality; however, long-term neurological recovery continues to be limited. In recent years, a number of exciting neuroprotective and regenerative strategies have emerged and have come under active investigation in clinical trials, and several more are coming down the translational pipeline. Read More

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http://dx.doi.org/10.3171/2018.9.SPINE18682DOI Listing
December 2018
3 Reads

The IASP classification of chronic pain for ICD-11: chronic neuropathic pain.

Pain 2019 Jan;160(1):53-59

Department of Neurophysiology, CBTM, Medical Faculty Mannheim of Heidelberg University, Mannheim, Germany.

The upcoming 11th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD) of the World Health Organization (WHO) offers a unique opportunity to improve the representation of painful disorders. For this purpose, the International Association for the Study of Pain (IASP) has convened an interdisciplinary task force of pain specialists. Here, we present the case for a reclassification of nervous system lesions or diseases associated with persistent or recurrent pain for ≥3 months. Read More

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http://Insights.ovid.com/crossref?an=00006396-201901000-0000
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http://dx.doi.org/10.1097/j.pain.0000000000001365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310153PMC
January 2019
12 Reads
5.213 Impact Factor

Ageing, Disability, and Spinal Cord Injury: Some Issues of Analysis.

Curr Gerontol Geriatr Res 2018 19;2018:4017858. Epub 2018 Nov 19.

Department of Education Psychology and Philosophy, State University of Cagliari, Italy.

Spinal cord injury is a disabling disorder, worldwide spread, with important consequences on functioning and health conditions and impacts on physical, psychological, and social well-being. The consequences are related to the lesion itself and to other complications related to the lesion. In the last decades, there have been an increasing of the mean ages of onset and also an increase in life expectancy after the lesion. Read More

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https://www.hindawi.com/journals/cggr/2018/4017858/
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http://dx.doi.org/10.1155/2018/4017858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276527PMC
November 2018
8 Reads

Mitochondrial health and muscle plasticity after spinal cord injury.

Eur J Appl Physiol 2019 Feb 11;119(2):315-331. Epub 2018 Dec 11.

James J. Peters VA Medical Center, Bronx, NY, USA.

Mitochondria are responsible for aerobic respiration and large-scale ATP production in almost all cells of the body. Their function is decreased in many neurodegenerative and cardiovascular disease states, in metabolic disorders such as type II diabetes and obesity, and as a normal component of aging. Disuse of skeletal muscle from immobilization or unloading triggers alterations of mitochondrial density and activity. Read More

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http://link.springer.com/10.1007/s00421-018-4039-0
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http://dx.doi.org/10.1007/s00421-018-4039-0DOI Listing
February 2019
15 Reads

Chronic Intermittent Hypoxia Induces Robust Astrogliosis in an Alzheimer's Disease-Relevant Mouse Model.

Neuroscience 2019 02 7;398:55-63. Epub 2018 Dec 7.

Spinal Cord & Brain Injury Research Center, University of Kentucky, Lexington, KY, United States; Department of Neuroscience, University of Kentucky, Lexington, KY, United States. Electronic address:

Sleep disturbances are a common early symptom of neurodegenerative diseases, including Alzheimer's disease (AD) and other age-related dementias, and emerging evidence suggests that poor sleep may be an important contributor to development of amyloid pathology. Of the causes of sleep disturbances, it is estimated that 10-20% of adults in the United States have sleep-disordered breathing (SDB) disorder, with obstructive sleep apnea accounting for the majority of the SBD cases. The clinical and epidemiological data clearly support a link between sleep apnea and AD; yet, almost no experimental research is available exploring the mechanisms associated with this correlative link. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2018.11.040DOI Listing
February 2019

Biomaterials and Gene Manipulation in Stem Cell-Based Therapies for Spinal Cord Injury.

Stem Cells Dev 2019 Jan 28. Epub 2019 Jan 28.

1 Regenerative Medicine Center, the First Affiliated Hospital of Dalian Medical University, Dalian, China.

Spinal cord injury (SCI), a prominent health issue, represents a substantial portion of the global health care burden. Stem cell-based therapies provide novel solutions for SCI treatment, yet obstacles remain in the form of low survival rate, uncontrolled differentiation, and functional recovery. The application of engineered biomaterials in stem cell therapy provides a physicochemical microenvironment that mimics the stem cell niche, facilitating self-renewal, stem cell differentiation, and tissue reorganization. Read More

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http://dx.doi.org/10.1089/scd.2018.0169DOI Listing
January 2019
3 Reads

Spinal Cord Injury From Spinal Tumors: Prevalence, Management, and Outcomes.

World Neurosurg 2019 Feb 22;122:e1551-e1556. Epub 2018 Nov 22.

Department of Orthopaedic Surgery, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA. Electronic address:

Background: With the aging population in the United States, it can be anticipated that the prevalence of spinal cord injuries (SCIs) and cancer will increase. Primary or metastatic spine tumors sit at a unique intersection of these 2 realms. Our objective was to evaluate the prevalence, outcomes, and complications after the management of SCI arising from spinal tumors. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.11.099DOI Listing
February 2019
1 Read

Reducing age-dependent monocyte-derived macrophage activation contributes to the therapeutic efficacy of NADPH oxidase inhibition in spinal cord injury.

Brain Behav Immun 2019 Feb 16;76:139-150. Epub 2018 Nov 16.

Spinal Cord and Brain Injury Research Center (SCoBIRC), Department of Physiology, University of Kentucky, Lexington, KY 40536, United States. Electronic address:

Objective: The average age at the time of spinal cord injury (SCI) has increased to 43 years old. Middle-aged mice (14 months old, MO) exhibit impaired recovery after SCI with age-dependent increases in reactive oxygen species (ROS) production through NADPH oxidase (NOX) along with pro-inflammatory macrophage activation. Despite these aging differences, clinical therapies are being examined in individuals regardless of age based upon preclinical data generated primarily using young animals (∼4 MO). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08891591183034
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http://dx.doi.org/10.1016/j.bbi.2018.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348135PMC
February 2019
7 Reads
5.889 Impact Factor

Efficacy of leukemia inhibitory factor as a therapeutic for permanent large vessel stroke differs among aged male and female rats.

Brain Res 2019 Mar 13;1707:62-73. Epub 2018 Nov 13.

Department of Neurology, University of Kentucky, 741 S. Limestone, Lexington, KY 40536, United States; Department of Neuroscience, University of Kentucky, 800 Rose St., Lexington, KY 40536, United States. Electronic address:

Preclinical studies using rodent models of stroke have had difficulty in translating their results to human patients. One possible factor behind this inability is the lack of studies utilizing aged rodents of both sexes. Previously, this lab showed that leukemia inhibitory factor (LIF) promoted recovery after stroke through antioxidant enzyme upregulation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00068993183057
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http://dx.doi.org/10.1016/j.brainres.2018.11.017DOI Listing
March 2019
11 Reads

Motor Recovery after Chronic Spinal Cord Transection: A Proof-of-Concept Study evaluating a Combined Strategy.

CNS Neurol Disord Drug Targets 2018 Nov 4. Epub 2018 Nov 4.

Centro de Investigación en Ciencias de la Salud (CICSA), Universidad Anáhuac México Campus Norte, Huixquilucan Estado de México. Mexico.

BACKROUND- Chronic spinal cord (SC) injury is a hostile phase for regeneration known as a period of low activity with a progressive decline in neurological function. Several strategies have been investigated in this regard with no satisfactory results. OBJECTIVE- In this proof-of-concept study, we combine scar removal plus implantation of fibrin glue impregnated with mesenchymal stem cells, and immunization with neural derived peptides was included as well. Read More

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http://dx.doi.org/10.2174/1871527317666181105101756DOI Listing
November 2018
9 Reads

Aging Is Associated With Impaired Activation of Protein Homeostasis-Related Pathways After Cardiac Arrest in Mice.

J Am Heart Assoc 2018 Sep;7(17):e009634

1 Center for Perioperative Organ Protection Department of Anesthesiology Duke University Medical Center Durham NC.

Background The mechanisms underlying worse outcome at advanced age after cardiac arrest ( CA ) and resuscitation are not well understood. Because protein homeostasis (proteostasis) is essential for cellular and organismal health, but is impaired after CA , we investigated the effects of age on proteostasis-related prosurvival pathways activated after CA . Methods and Results Young (2-3 months old) and aged (21-22 months old) male C57Bl/6 mice were subjected to CA and cardiopulmonary resuscitation ( CPR ). Read More

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https://www.ahajournals.org/doi/10.1161/JAHA.118.009634
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http://dx.doi.org/10.1161/JAHA.118.009634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201440PMC
September 2018
9 Reads
2.880 Impact Factor

A Valid and Precise Semiautomated Method for Quantifying INTERmuscular Fat INTRAmuscular Fat in Lower Leg Magnetic Resonance Images.

J Clin Densitom 2018 Sep 22. Epub 2018 Sep 22.

University Health Network, Osteoporosis Program, Toronto General Research Institute, Toronto, Ontario, Canada.

The accumulation of INTERmuscular fat and INTRAmuscular fat (IMF) has been a hallmark of individuals with diabetes, those with mobility impairments such as spinal cord injuries and is known to increase with aging. An elevated amount of IMF has been associated with fractures and frailty, but the imprecision of IMF measurement has so far limited the ability to observe more consistent clinical associations. Magnetic resonance imaging has been recognized as the gold standard for portraying these features, yet reliable methods for quantifying IMF on magnetic resonance imaging is far from standardized. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10946950183013
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http://dx.doi.org/10.1016/j.jocd.2018.09.007DOI Listing
September 2018
10 Reads

Cardiorespiratory fitness and arm bone mineral health in young males with spinal cord injury: the mediator role of lean mass.

J Sports Sci 2019 Apr 13;37(7):717-725. Epub 2018 Oct 13.

a GENUD Toledo Research Group , Universidad de Castilla-La Mancha , Toledo , Spain.

Spinal cord injury (SCI) derives in loss of bone mineral content (BMC) and bone mineral density (BMD). However, physical activity is an important determinant in bone mass acquisition, which is partially mediated through the lean mass (LM). The aim was to examine the effect of cardiorespiratory fitness (CRF) on BMD and BMC arms of adult males with SCI and able-bodied controls using the arm LM as a mediator variable. Read More

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https://www.tandfonline.com/doi/full/10.1080/02640414.2018.1
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http://dx.doi.org/10.1080/02640414.2018.1522948DOI Listing
April 2019
7 Reads

Changes in perceived social support predict changes in depressive symptoms in adults with physical disability.

Disabil Health J 2018 Oct 5. Epub 2018 Oct 5.

Department of Rehabilitation Medicine, University of Washington, Harborview Medical Center, Box 359612, 325 Ninth Avenue, Seattle, WA, 98104-2499, USA.

Background: Perceived social support has been found to be associated with depression, subjective well-being and psychological health in cross-sectional studies in people with physical disabilities. No longitudinal studies have been conducted to examine these associations over time using a comprehensive measure of social support.

Objective/hypothesis: We hypothesized that: (1) the amount of perceived social support would be similar across individuals with different diagnoses often associated with disability (i. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19366574183019
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http://dx.doi.org/10.1016/j.dhjo.2018.09.005DOI Listing
October 2018
1 Read

Chronic Traumatic Encephalopathy Within an Amyotrophic Lateral Sclerosis Brain Bank Cohort.

J Neuropathol Exp Neurol 2018 Dec;77(12):1091-1100

VA Boston Healthcare System, Boston, Massachusetts.

Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disorder linked to repetitive head impacts and has been associated with amyotrophic lateral sclerosis (ALS), a fatal, degenerative neuromuscular disorder. The Department of Veterans Affairs Biorepository Brain Bank (VABBB) is a tissue repository that collects antemortem disease progression data and postmortem central nervous system tissue from veterans with ALS. We set out to determine the frequency of co-morbid ALS and CTE in the VABBB cohort and to characterize the clinical, genetic, and pathological distinctions between participants with ALS only and those with both ALS and CTE (ALS+CTE). Read More

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https://academic.oup.com/jnen/article/77/12/1091/5123933
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http://dx.doi.org/10.1093/jnen/nly092DOI Listing
December 2018
19 Reads

Sex/gender disparities in health outcomes of individuals with long-term disabling conditions.

Rehabil Psychol 2018 Oct 8. Epub 2018 Oct 8.

Department of Rehabilitation Medicine.

Background: Women with disabling conditions experience health disparities relative to nondisabled women, but few studies have compared women and men with disabling conditions.

Objectives: To investigate gender differences in physical functioning and emotional health among individuals with long-term disabling conditions, that is, neuromuscular disease, multiple sclerosis, postpolio syndrome, or spinal cord injury.

Method: From a mailed survey of 1,862 adults with long-term disabling conditions, we used the 12-item Patient-Reported Outcomes Measurement Information System (PROMIS) physical functioning to assess physical limitations in activities and Patient Health Questionnaire-9 (PHQ-9) for emotional health and severity of secondary conditions (rated 0-10). Read More

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http://doi.apa.org/getdoi.cfm?doi=10.1037/rep0000248
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http://dx.doi.org/10.1037/rep0000248DOI Listing
October 2018
11 Reads

Age Influences Microglial Activation After Cuprizone-Induced Demyelination.

Front Aging Neurosci 2018 20;10:278. Epub 2018 Sep 20.

Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria.

Multiple sclerosis (MS) is a chronic inflammatory CNS disease, which causes demyelinated lesions and damages white and gray matter regions. Aging is a significant factor in the progression of MS, and microglia, the immune cells of the CNS tissue, play an important role in all disease stages. During aging, microglia are functionally altered. Read More

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https://www.frontiersin.org/article/10.3389/fnagi.2018.00278
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http://dx.doi.org/10.3389/fnagi.2018.00278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160739PMC
September 2018
4 Reads

Aging alters glucose uptake in the naïve and injured rodent spinal cord.

Neurosci Lett 2019 01 6;690:23-28. Epub 2018 Oct 6.

Neuroscience Program, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA; Department of Anatomy, Physiology, and Genetics, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA; Center for Neuroscience and Regenerative Medicine, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD, USA. Electronic address:

Aging results in increased activation of inflammatory glial cells and decreased neuronal viability following spinal cord injury (SCI). Metabolism and transport of glucose is also decreased with age, although the influence of age on glucose transporter (GLUT) expression or glucose uptake in SCI is currently unknown. We therefore performed [F]Fluorodeoxyglucose (FDG) PET imaging of young (3 month) and middle-aged (12 month) rats. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03043940183067
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http://dx.doi.org/10.1016/j.neulet.2018.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320289PMC
January 2019
2 Reads

Adult spinal motoneurons change their neurotransmitter phenotype to control locomotion.

Proc Natl Acad Sci U S A 2018 10 1;115(42):E9926-E9933. Epub 2018 Oct 1.

Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden

A particularly essential determinant of a neuron's functionality is its neurotransmitter phenotype. While the prevailing view is that neurotransmitter phenotypes are fixed and determined early during development, a growing body of evidence suggests that neurons retain the ability to switch between different neurotransmitters. However, such changes are considered unlikely in motoneurons due to their crucial functional role in animals' behavior. Read More

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http://www.pnas.org/lookup/doi/10.1073/pnas.1809050115
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http://dx.doi.org/10.1073/pnas.1809050115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196516PMC
October 2018
12 Reads

Magnitude of dural tube compression does not show a predictive value for symptomatic lumbar spinal stenosis for 1-year follow-up: a prospective cohort study in the community.

Clin Interv Aging 2018 13;13:1739-1746. Epub 2018 Sep 13.

Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan,

Background: The North American Spine Society states that lumbar spinal stenosis (LSS) is a clinical syndrome, and there is insufficient evidence to make a recommendation for or against a correlation between clinical symptoms or function and the presence of anatomic narrowing of the spinal canal on MRI. The main purpose of this study was to assess the influence of the magnitude of dural tube compression on MRI on LSS symptoms at the cross-sectional and 1-year follow-up.

Methods: This was a prospective cohort study of 459 participants who were assessed for LSS using a questionnaire and conventional MRI of the lumbar spine. Read More

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https://www.dovepress.com/magnitude-of-dural-tube-compressio
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http://dx.doi.org/10.2147/CIA.S171049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145355PMC
December 2018
1 Read

Brainstem Imaging in Alzheimer's Disease: Potential for Biomarker Development.

Front Aging Neurosci 2018 11;10:266. Epub 2018 Sep 11.

Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, United States.

The dearth of effective treatments for Alzheimer's disease (AD) is one of the largest public health issues worldwide, costing hundreds of billions of dollars per year. From a therapeutic standpoint, research efforts to date have met with strikingly little clinical success. One major issue is that trials begin after substantial pathological change has occurred, and it is increasingly clear that the most effective treatment regimens will need to be administered earlier in the disease process. Read More

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http://dx.doi.org/10.3389/fnagi.2018.00266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141632PMC
September 2018
9 Reads

Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease.

Neurobiol Aging 2018 Dec 9;72:188.e3-188.e12. Epub 2018 Aug 9.

Medical Genomics Research Unit, GIGA-R, University of Liège, Belgium; Walloon Excellence in Life sciences and BIOtechnology (WELBIO), Belgium; Department of Human Genetics, KU Leuven, Leuven, Belgium.

Systematic epistasis analyses in multifactorial disorders are an important step to better characterize complex genetic risk structures. We conducted a hypothesis-free sex-stratified genome-wide screening for epistasis contributing to Alzheimer's disease (AD) susceptibility. We identified a statistical epistasis signal between the single nucleotide polymorphisms rs3733980 and rs7175766 that was associated with AD in males (genome-wide significant p=0. Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.08.001DOI Listing
December 2018
4 Reads

Epidemiological Features of Spinal Cord Injury in China: A Systematic Review.

Front Neurol 2018 22;9:683. Epub 2018 Aug 22.

Department of Orthopaedics, Tianjin Medical University General Hospital, Tianjin, China.

Spinal cord injury (SCI) is a severe condition that disrupts patients' physiological, mental, and social well-being state and exerts great financial burden on patients, their families and social healthcare system. This review intends to compile studies regarding epidemiological features of SCI in China. Searches were conducted on PubMed, EMBASE, Web of Science and Cochrane Library for relevant studies published through January, 2018. Read More

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http://dx.doi.org/10.3389/fneur.2018.00683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113592PMC
August 2018
2 Reads

Early postnatal behavioral, cellular, and molecular changes in models of Huntington disease are reversible by HDAC inhibition.

Proc Natl Acad Sci U S A 2018 09 27;115(37):E8765-E8774. Epub 2018 Aug 27.

Department of Experimental Therapy, Friedrich-Alexander-University, 91054 Erlangen, Germany;

Huntington disease (HD) is an autosomal dominant neurodegenerative disorder caused by expanded CAG repeats in the gene (). Although mutant HTT is expressed during embryonic development and throughout life, clinical HD usually manifests later in adulthood. A number of studies document neurodevelopmental changes associated with mutant , but whether these are reversible under therapy remains unclear. Read More

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http://www.pnas.org/lookup/doi/10.1073/pnas.1807962115
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http://dx.doi.org/10.1073/pnas.1807962115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140493PMC
September 2018
6 Reads
9.810 Impact Factor

Adipose-derived cells improve left ventricular diastolic function and increase microvascular perfusion in advanced age.

PLoS One 2018 24;13(8):e0202934. Epub 2018 Aug 24.

Cardiovascular Innovation Institute, University of Louisville, Louisville, Kentucky, United States of America.

An early manifestation of coronary artery disease in advanced age is the development of microvascular dysfunction leading to deficits in diastolic function. Our lab has previously shown that epicardial treatment with adipose-derived stromal vascular fraction (SVF) preserves microvascular function following coronary ischemia in a young rodent model. Follow-up studies showed intravenous (i. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202934PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108481PMC
February 2019
1 Read

Depression following a traumatic brain injury: uncovering cytokine dysregulation as a pathogenic mechanism.

Neural Regen Res 2018 Oct;13(10):1693-1704

Spinal Cord & Brain Injury Research Center, University of Kentucky; Department of Neuroscience, University of Kentucky, Lexington, KY, USA.

A substantial number of individuals have long-lasting adverse effects from a traumatic brain injury (TBI). Depression is one of these long-term complications that influences many aspects of life. Depression can limit the ability to return to work, and even worsen cognitive function and contribute to dementia. Read More

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http://dx.doi.org/10.4103/1673-5374.238604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128046PMC
October 2018
1 Read

Residential location of people with chronic spinal cord injury: the importance of local health care infrastructure.

BMC Health Serv Res 2018 Aug 22;18(1):657. Epub 2018 Aug 22.

Swiss Paraplegic Research, Nottwil, Switzerland.

Background: People with spinal cord injury (SCI) suffer from complex secondary health conditions and rely on specialized health care services, which are often centralized and difficult to reach for individuals living in remote areas. As a consequence, they might move to regions where they expect better access to care. The aims of this study were: 1) to identify regions where people with SCI live compared with the general population, 2) to examine whether their choice of residence is related to the availability of local health care infrastructure, and 3) to ascertain determinants of their consideration to change residence when aging. Read More

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http://dx.doi.org/10.1186/s12913-018-3449-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106887PMC
August 2018
2 Reads

Doxorubicin-induced elevated oxidative stress and neurochemical alterations in brain and cognitive decline: protection by MESNA and insights into mechanisms of chemotherapy-induced cognitive impairment ("chemobrain").

Oncotarget 2018 Jul 13;9(54):30324-30339. Epub 2018 Jul 13.

Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA.

Chemotherapy-induced cognitive impairment (CICI) is now widely recognized as a real and too common complication of cancer chemotherapy experienced by an ever-growing number of cancer survivors. Previously, we reported that doxorubicin (Dox), a prototypical reactive oxygen species (ROS)-producing anti-cancer drug, results in oxidation of plasma proteins, including apolipoprotein A-I (ApoA-I) leading to tumor necrosis factor-alpha (TNF-α)-mediated oxidative stress in plasma and brain. We also reported that co-administration of the antioxidant drug, 2-mercaptoethane sulfonate sodium (MESNA), prevents Dox-induced protein oxidation and subsequent TNF-α elevation in plasma. Read More

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http://dx.doi.org/10.18632/oncotarget.25718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084398PMC
July 2018
4 Reads

The protective effect of microRNA-21 in neurons after spinal cord injury.

Spinal Cord 2019 Feb 8;57(2):141-149. Epub 2018 Aug 8.

Department of Sports Medicine, Research Center of Sports Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.

Study Design: Experimental animal study.

Objectives: To validate the anti-apoptosis effect of microRNA-21 in neurons after spinal cord injury (SCI) and explore the mechanism.

Setting: Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China. Read More

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http://dx.doi.org/10.1038/s41393-018-0180-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358587PMC
February 2019
2 Reads

RNA binding proteins co-localize with small tau inclusions in tauopathy.

Acta Neuropathol Commun 2018 Aug 1;6(1):71. Epub 2018 Aug 1.

Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.

The development of insoluble, intracellular neurofibrillary tangles composed of the microtubule-associated protein tau is a defining feature of tauopathies, including Alzheimer's disease (AD). Accumulating evidence suggests that tau pathology co-localizes with RNA binding proteins (RBPs) that are known markers for stress granules (SGs). Here we used proteomics to determine how the network of tau binding proteins changes with disease in the rTg4510 mouse, and then followed up with immunohistochemistry to identify RNA binding proteins that co-localize with tau pathology. Read More

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http://dx.doi.org/10.1186/s40478-018-0574-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069705PMC
August 2018
9 Reads

Prescription drug claims following a traumatic spinal cord injury for older adults: a retrospective population-based study in Ontario, Canada.

Spinal Cord 2018 Nov 31;56(11):1059-1068. Epub 2018 Jul 31.

Institute for Clinical Evaluative Sciences, Toronto, ON, Canada.

Study Design: Retrospective cohort study.

Objectives: The objectives for this study were to examine the prevalence of polypharmacy for people with traumatic spinal cord injury (SCI) following injury and to determine risk factors.

Setting: Ontario, Canada METHODS: We used provincial-level administrative health services data of publicly funded healthcare encounters housed at the Institute for Clinical Evaluative Sciences, Toronto, Ontario. Read More

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http://dx.doi.org/10.1038/s41393-018-0174-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218396PMC
November 2018
3 Reads

Denervation-activated STAT3-IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis.

Nat Cell Biol 2018 Aug 26;20(8):917-927. Epub 2018 Jul 26.

IRCCS, Fondazione Santa Lucia, Rome, Italy.

Fibro-adipogenic progenitors (FAPs) are typically activated in response to muscle injury, and establish functional interactions with inflammatory and muscle stem cells (MuSCs) to promote muscle repair. We found that denervation causes progressive accumulation of FAPs, without concomitant infiltration of macrophages and MuSC-mediated regeneration. Denervation-activated FAPs exhibited persistent STAT3 activation and secreted elevated levels of IL-6, which promoted muscle atrophy and fibrosis. Read More

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http://dx.doi.org/10.1038/s41556-018-0151-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145844PMC
August 2018
5 Reads

Astrocyte Neuroprotection and Dehydroepiandrosterone.

Vitam Horm 2018 19;108:175-203. Epub 2018 Feb 19.

Laboratório de Interação Neuro-Humoral, ICBS, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.

Dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) are the most abundant steroid hormones in the systemic circulation of humans. Due to their abundance and reduced production during aging, these hormones have been suggested to play a role in many aspects of health and have been used as drugs for a multiple range of therapeutic actions, including hormonal replacement and the improvement of aging-related diseases. In addition, several studies have shown that DHEA and DHEAS are neuroprotective under different experimental conditions, including models of ischemia, traumatic brain injury, spinal cord injury, glutamate excitotoxicity, and neurodegenerative diseases. Read More

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http://dx.doi.org/10.1016/bs.vh.2018.01.004DOI Listing
November 2018
3 Reads

The effect of positive changes during intraoperative monitoring of the functional improvement in patients with cervical compressive myelopathy.

Clin Interv Aging 2018 5;13:1211-1218. Epub 2018 Jul 5.

Department of Rehabilitation Medicine, Jeju National University School of Medicine, Jeju National University Hospital, Jeju, Republic of Korea.

Background: Cervical compressive myelopathy (CCM) is a progressive, degenerative spine disease and the most common cause of spinal cord dysfunction in older individuals. Current clinical guidelines for spinal surgery recommend multimodal intraoperative monitoring (IOM) during spinal surgery as a reliable and valid diagnostic adjunct to assess spinal cord integrity. The aim of this study was to evaluate the effect of positive changes during IOM on the functional status in patients with CCM. Read More

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http://dx.doi.org/10.2147/CIA.S163467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038868PMC
October 2018
4 Reads

Special considerations in the urological management of the older spinal cord injury patient.

World J Urol 2018 Jul 12. Epub 2018 Jul 12.

Department of Medicine, University of Alberta, Edmonton, Canada.

Purpose: This paper reports the key findings of Committee 8 of the Joint SIU-ICUD Consultation on Urologic Management of the Spinal Cord Injured Patient and address issues pertaining to the older person with a SCI and the time-related changes relevant to their urological, gastrointestinal and functional management.

Methods: A literature review using the Pubmed and Ovid search engines was performed examining pertinent literature regarding SCI in the older patient.

Results: There is a rising incidence of both traumatic and non-traumatic spinal cord injury (SCI) in older people and improvements in healthcare and nutrition mean patients with SCI are living longer. Read More

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http://dx.doi.org/10.1007/s00345-018-2326-3DOI Listing
July 2018
14 Reads