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Front Surg 2022 9;9:886391. Epub 2022 May 9.

Instituto Nacional de Neurología y Neurocirugía, Neuroendovascular Therapy, Mexico City, Mexico.

Background: Stereotactic and functional neurosurgery (SFN) is a rapidly evolving field and some emerging countries, especially Mexico, have made significant contributions to this discipline. A bibliometric analysis has never been performed in Latin America, and this would be particularly important to show the areas that remain poorly studied, and design research strategies for the future.

Methods: Scopus was queried using keywords pertaining to functional neurosurgery, restricting the affiliation country to Mexico, and considering documents published after 1949. Read More

Am J Physiol Cell Physiol 2022 May 25. Epub 2022 May 25.

Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.

The brain and spinal cord constitute the central nervous system (CNS), which when injured, can be exceedingly devastating. The mechanistic roles of proteoglycans (PGs) and their glycosaminoglycan (GAG) side chains in such injuries have been extensively studied. CNS injury immediately alters endothelial and extracellular matrix (ECM) PGs and GAGs. Read More

Physiol Rep 2022 May;10(10):e15266

Research Service, Birmingham VA Medical Center, Birmingham, Alabama, USA.

Spinal cord injury (SCI) leads to major reductions in function, independent living, and quality of life. Disuse and paralysis from SCI leads to rapid muscle atrophy, with chronic muscle loss likely playing a role in the development of the secondary metabolic disorders often seen in those with SCI. Muscle disuse is associated with mitochondrial dysfunction. Read More

Spinal Cord Ser Cases 2022 May 24;8(1):57. Epub 2022 May 24.

Neuro-Urology, Schweizer Paraplegiker Zentrum, Nottwil, Switzerland.

Study Design: This study is a retrospective chart analysis.

Objectives: Surgical treatment of stress urinary incontinence (SUI) in women with neurogenic lower urinary tract dysfunction (NLUTD) is a challenge, as minimally invasive procedures do not seem to be effective, whereas synthetic implants are associated with substantial risks. Thus, we evaluated the results of an autologous sling procedure in this group of patients SETTING: This study was performed at a spinal cord injury rehabilitation center in Switzerland. Read More

J Spinal Cord Med 2022 May;45(3):325-326

Beaumont Hospital, Royal Oak Campus, Royal Oak, MI.

J Neurotrauma 2022 May 24. Epub 2022 May 24.

Hospital Nacional de Paraplejicos, Laboratory of Neuroinflammation, Finca la Peraleda, s/n, Toledo, Spain, 45071;

Patients with spinal cord injury (SCI) frequently develop infections that may affect quality of life, be life-threatening, and impair their neurological recovery in the acute and subacute injury phase. Therefore, identifying SCI patients at risk for developing infections in this stage is of utmost importance. We determined the systemic levels of immune cell populations, cytokines, chemokines and growth factors in 81 patients with traumatic SCI at 4 weeks after injury and compared them with those of 26 age-matched healthy control subjects. Read More

A A Pract 2022 May 1;16(5):e01595. Epub 2022 May 1.

From the Department of Anesthesiology, the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

A 31-year-old G2P1 (gravida 2 para 1) woman at 34 weeks of gestation presented after a motor vehicle collision with an incomplete cervical spinal cord injury. The patient underwent emergent anterior cervical decompression and fusion (ACDF), immediately followed by cesarean delivery. We discuss the clinical decision making to perform ACDF first, weighing risks and benefits to both mother and baby. Read More

Disabil Rehabil 2022 May 21:1-14. Epub 2022 May 21.

Department of Clinical Neurosciences, Division of Physical Medicine and Rehabilitation, University of Calgary, Calgary, AB, Canada.

Purpose: Spinal cord injury (SCI) has lifelong implications requiring treatment for outcomes including respiratory function, voice, pain, mood, and gait, among others. Music therapy (MT) and music-based interventions may be useful in the treatment of several outcomes. This review describes the use of MT and music-based interventions in individuals with SCI for rehabilitation and health and highlights future research priorities. Read More

J Caring Sci 2022 Mar 15;11(1):1-6. Epub 2022 Jan 15.

Department of Critical Care Nursing, Nursing and Midwifery Care Research Center, School of Nursing and Midwifery, Tehran.

There are numerous dressings used to treat pressure ulcers (PUs), depending on their advantages to achieve optimum patient outcomes. This study aimed to compare hydrocolloid dressings and silver nanoparticles in treating PUs among patients with spinal cord injury (SCI). This randomized clinical trial was conducted on 70 patients with SCI in Iran. Read More

Cureus 2022 Apr 20;14(4):e24314. Epub 2022 Apr 20.

Neurological Surgery, University of Alabama at Birmingham, Birmingham, USA.

Ice hockey is a high-speed sport with a high rate of associated injury, including spinal cord injury (SCI). The incidence of hockey-related SCI has increased significantly in more recent years. A comprehensive literature search was conducted with the PubMed, Medline, Google Scholar, and Web of Science databases using the phrases "hockey AND spinal cord injuries" to identify relevant studies pertaining to hockey-related SCIs, equipment use, anatomy, and biomechanics of SCI, injury recognition, and return-to-play guidelines. Read More

Comput Intell Neurosci 2022 11;2022:7619797. Epub 2022 May 11.

Department of Orthopaedics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250014, Shandong, China.

Spinal cord reperfusion injury as a secondary damage after primary spinal cord injury is an important factor causing nerve cell damage. In this study, we aim to investigate the effects and mechanisms of tanshinone (TAE) in the rabbit spinal cord during ischemia-reperfusion. New Zealand white rabbits were randomly divided into 3 groups: sham-operated group (5 rabbits), ischemia-reperfusion group (0. Read More

Oxid Med Cell Longev 2022 13;2022:8659587. Epub 2022 May 13.

Department of Anesthesiology, Zhongnan Hospital of Wuhan University, China.

Objective: Inflammation and oxidative stress are implicated in the pathogenesis of spinal cord injury (SCI). The present study is aimed at investigating the function and molecular basis of microRNA-299a-5p (miR-299a-5p) during SCI in mice.

Methods: Mice were exposed to SCI surgery and then intrathecally injected with the agomir, antagomir, or matched negative controls of miR-299a-5p to overexpress or silence miR-299a-5p. Read More

Spinal Cord Ser Cases 2022 May 21;8(1):56. Epub 2022 May 21.

Department of Spinal Cord Injury, Veterans Affairs New Jersey Health Care System, East Orange, NJ, 07018, USA.

Introduction: Oral baclofen is commonly used for spasticity management, especially with neurogenic bladder in spinal cord injury (SCI). A less common side effect of baclofen is transient alterations of consciousness, which can easily be confused for altered mental status secondary to orthostatic hypotension in SCI.

Case Presentation: A 43-year-old man with an acute SCI secondary to an aortic dissection was found to have episodes of confusion after titrating oral baclofen from 5 mg three times per day to 10 mg three times per day at an acute rehabilitation facility. Read More

Am J Phys Med Rehabil 2022 Jun 3;101(6):e95-e97. Epub 2022 Feb 3.

From the Division of Physical Medicine and Rehabilitation, Department of Orthopaedics, Washington University School of Medicine, St Louis, Missouri (GD); and Washington University School of Medicine, St Louis, Missouri (AL).

Abstract: An otherwise healthy 21-yr-old female hockey player sustained a cervical whiplash injury during competition after being checked and falling backward onto the ice. Initial assessment revealed right-sided hemiparesis and sensory abnormalities. Magnetic resonance imaging and computed tomography of the brain and spine were unremarkable. Read More

Clin Transl Med 2022 May;12(5):e884

Emerging Innovations Unit, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, UK.

Sensors (Basel) 2022 May 7;22(9). Epub 2022 May 7.

Graduate Program in Neuroengineering, Edmond and Lily Safra International Institute of Neuroscience, Santos Dumont Institute, Av. Alberto Santos Dumont, 1560, Zona Rural, Macaiba 59280-000, RN, Brazil.

The most used approach in the motor rehabilitation of spinal cord injury is functional electrical stimulation. However, current devices do not provide real-time feedback, work in the closed-loop, and became remotely operable. In this scenario, this paper presents the development of an open access 4-channel IoT electrostimulator device with an inertial sensor. Read More

Biotechnol Adv 2022 May 16;59:107983. Epub 2022 May 16.

Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel. Electronic address:

In recent years, extracellular vesicles (EVs), specifically exosomes, have emerged as a promising strategy for treating a wide spectrum of pathologies, such as cancer and COVID-19, as well as promoting tissue regeneration in various conditions, including cardiomyopathies and spinal cord injuries. Despite the great potential of EV-based therapies, poor yield and unscalable production of EVs remain big challenges to overcome to translate these types of treatment to clinical practices. Here, we review different strategies for enhancing EV yield by physical, biological or chemical means. Read More

Arch Phys Med Rehabil 2022 May 16. Epub 2022 May 16.

Center for Rehabilitation Outcomes Research, Shirley Ryan AbilityLab, Chicago, IL 60611, USA, and Departments of Physical Medicine & Rehabilitation and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address:

Objectives: This study aimed to describe the process of adapting an evidence-based patient engagement intervention, Enhanced Medical Rehabilitation (E-MR), for inpatient spinal cord injury/disease (SCI/D) rehabilitation using an implementation science framework.

Design: We applied the Collaborative Intervention Planning Framework (CIPF) and included a community advisory board (CAB) in an intervention mapping process.

Setting: A rehabilitation hospital. Read More

Rehabil Psychol 2022 May 19. Epub 2022 May 19.

Department of Rehabilitation Medicine.

Objective: To explore health care professionals' perceptions of ideal strategies for providers to use in care provision to help individuals with spinal cord injuries (SCI) deal with injury-related grief and loss.

Method: This study used a descriptive qualitative design using semistructured interviews with 15 SCI health providers and thematic analysis.

Results: The sample included interprofessional health providers who provided SCI care for an average of 10. Read More

Anal Bioanal Chem 2022 May 19. Epub 2022 May 19.

Institute of Chemistry of Organometallic Compounds, ICCOM-CNR-Pisa, Pisa, Italy.

Raman spectroscopy is an emerging tool in the research and diagnosis of different diseases, including neurodegenerative disorders. In this work, blood serum samples collected from healthy controls and dementia patients were analysed by Raman spectroscopy to develop a classification model for the diagnosis of dementia of Alzheimer's type (DAT). Raman spectra were processed by means of multivariate tools for multivariate analysis. Read More

IBRO Neurosci Rep 2022 Jun 14;12:366-376. Epub 2022 Apr 14.

Neuroanatomy Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.

In the acute phase of spinal cord injury, the initial injury triggers secondary damage due to neuroinflammation, leading to the formation of cavities and glial scars that impair nerve regeneration. Following injuries to the central nervous system, early mobilization promotes the recovery of physical function. Therefore, in the present study, we investigated the effects of early mobilization on motor function recovery and neuroinflammation in rats. Read More

N Am Spine Soc J 2022 Jun 30;10:100119. Epub 2022 Apr 30.

Department of Neurosurgery, Oslo University Hospital, Oslo, Norway.

Background: Bicyclists are vulnerable road users. The aim of this paper was to describe all bicycle-related traumatic cervical spine injuries (CSIs) in the South-East region of Norway (2015-2019), and to investigate whether certain types of CSIs are typical for bicyclists.

Methods: Retrospective cohort study of prospectively collected registry data of all CSIs in the South-East region of Norway (3. Read More

JAMA Surg 2022 May 18. Epub 2022 May 18.

Surgical Outcomes Quality Improvement Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Importance: Differences in time to diagnostic and therapeutic measures can contribute to disparities in outcomes. However, whether there is an association of timeliness by sex for trauma patients is unknown.

Objective: To investigate whether sex-based differences in time to definitive interventions exist for trauma patients in the US and whether these differences are associated with outcomes. Read More

Brain 2022 May 18. Epub 2022 May 18.

Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland.

Severe spinal cord injuries result in permanent paraparesis in spite of the frequent sparing of small portions of white matter. Spared fiber tracts are often incapable of maintaining and modulating the activity of lower spinal motor centers. Effects of rehabilitative training thus remain limited. Read More

FASEB J 2022 Jun;36(6):e22294

Department of Orthopedics, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Excessive neuroinflammation and neuronal loss contribute to mechanisms of spinal cord injury (SCI). Accumulating evidence has suggested that topoisomerase 1 (Top1) inhibition can suppress exacerbated immune responses and protect against lethal inflammation. Pyroptosis is a recently identified pro-inflammatory programmed mode of cell death. Read More

Curr Med Chem 2022 May 9. Epub 2022 May 9.

Department of Orthopedics, The Fourth Affiliated Hospital of China Medical University, No.4 Chongshan Dong Street, Huanggu District, Shenyang 110032, Liaoning Province, PR China.

Background Recent studies have indicated that epigallocatechin gallate (EGCG) benefits a variety of neurological insults. This study was performed to investigate the neuroprotective effect of EGCG after brachial plexus root avulsion in SD rats. Methods One hundred twenty SD rats were randomized into the following three groups: an EGCG group, an Avulsion group, and a Sham group. Read More

OTJR (Thorofare N J) 2022 May 14:15394492221097355. Epub 2022 May 14.

Karolinska Institutet, Huddinge, Sweden.

Understanding the process of return-to-work is key to supporting people's social participation and health after a disability. This phenomenographic study aimed to explore the expectations and ways of understanding return-to-work from the perspectives of three stakeholder types: three workers with spinal cord injuries, their employers, and an occupational therapist coordinator. Participants were interviewed twice, at 6 and 12 months, after having participated in a research-based return-to-work intervention in Sweden. Read More

Front Cell Neurosci 2022 28;16:885245. Epub 2022 Apr 28.

Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden.

Peripheral nerves have a propensity for axon growth and regeneration that the central nervous system lacks (CNS). However, CNS axons can also grow long distances if introduced to a graft harvested from a peripheral nerve (PNGs), which is the rationale for using PNGs as repair strategy for injuries of the spinal cord. From a clinical perspective, PNGs provide interesting possibilities with potential to repair the injured spinal cord. Read More

Arch Acad Emerg Med 2022 27;10(1):e31. Epub 2022 Apr 27.

Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: The mortality of burn injury is a serious health problem among older people. The present study aimed to determine the epidemiological characteristics of burn mortality and Years of Life Lost (YLLs) among people aged ≥ 60.

Methods: The National and Subnational Burden of Disease (NASBOD) study includes population-based cross-sectional data from the death registration system of Iran and those recorded by the cemeteries of Tehran and Esfahan were used in this study. Read More