54,707 results match your criteria Spinal Cord Injuries


Three-Dimensional Magnetic Resonance Imaging (MRI) of Mouse Facial Nerve Regeneration.

Front Neurol 2019 2;10:310. Epub 2019 Apr 2.

Institute of Physiological Chemistry, Ulm University, Ulm, Germany.

MRI (magnetic resonance imaging) is an indispensable tool in the diagnosis of centrals nervous system (CNS) disorders such as spinal cord injury and multiple sclerosis (MS). In contrast, diagnosis of peripheral nerve injuries largely depends on clinical and electrophysiological parameters. Thus, currently MRI is not regularly used which in part is due to small nerve calibers and isointensity with surrounding tissue such as muscles. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2019.00310
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http://dx.doi.org/10.3389/fneur.2019.00310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454117PMC
April 2019
1 Read

Is cast an option in the treatment of thoracolumbar vertebral fractures?

J Craniovertebr Junction Spine 2019 Jan-Mar;10(1):51-56

Orthopaedic and Trauma Centre, Spine Surgery Unit, Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy.

Background: Thoracolumbar vertebral fractures are common in high-energy trauma and often are associated to other concomitant injuries. Currently, brace and Closed Reduction and Casting (CRC) are the two conservative treatments proposed by literature. Despite CRC was widely used in the past, today brace is preferred. Read More

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http://www.jcvjs.com/text.asp?2019/10/1/51/255732
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http://dx.doi.org/10.4103/jcvjs.JCVJS_8_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469317PMC
April 2019
1 Read

Patient-level resource use for injury admissions in Canada: A multicentre retrospective cohort study.

Injury 2019 Mar 28. Epub 2019 Mar 28.

Institut national d'excellence en santé et en services sociaux (INESSS), Québec, QC, Canada; Department of Surgery, Université Laval, Québec, QC, Canada.

Background: Variations in adjusted costs have been observed among trauma centres in the United States but patient outcomes were not better in centres with higher costs. Attempts to improve injury care efficiency are hampered by insufficient patient-level information on resource use and on the drivers of resource use intensity.

Objectives: To estimate patient-level resource use for injury admissions, identify determinants of resource use intensity, and evaluate inter-hospital variations in resource use. Read More

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http://dx.doi.org/10.1016/j.injury.2019.03.038DOI Listing

Uro-Vaxom® versus placebo for the prevention of recurrent symptomatic urinary tract infections in participants with chronic neurogenic bladder dysfunction: a randomised controlled feasibility study.

Trials 2019 Apr 16;20(1):223. Epub 2019 Apr 16.

National Spinal Injuries Centre, Stoke Mandeville Hospital, Buckinghamshire Healthcare NHS Trust, Aylesbury, HP21 8AL, UK.

Background: Patients with lower neurogenic bladder dysfunction are at an increased risk of suffering from recurrent urinary tract infections. Recurrent symptomatic urinary tract infection is occasionally treated with antibiotics as a prophylactic prevention strategy. This risks increasing the frequency of antibiotic resistance. Read More

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https://trialsjournal.biomedcentral.com/articles/10.1186/s13
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http://dx.doi.org/10.1186/s13063-019-3275-xDOI Listing
April 2019
2 Reads

Current strategies for therapeutic drug delivery after traumatic CNS injury.

Ther Deliv 2019 Apr;10(4):251-263

Department of Neurology, University of Mississippi Medical Center, 2500 North, State Street, Jackson, MS 39216, USA.

Therapeutic strategies for traumatic injuries in the central nervous system (CNS) are largely limited to the efficiency of drug delivery. Despite the disrupted blood-CNS barrier during the early phase after injury, the drug administration faces a variety of obstacles derived from homeostatic imbalance at the injury site. In the late phase after CNS injury, the restoration of the blood-CNS barrier integrity varies depending on the injury severity resulting in inconsistent delivery of therapeutics. Read More

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https://www.future-science.com/doi/10.4155/tde-2019-0006
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http://dx.doi.org/10.4155/tde-2019-0006DOI Listing
April 2019
1 Read

Real-Time Performance of a Tactile Neuroprosthesis on Awake Behaving Rats.

IEEE Trans Neural Syst Rehabil Eng 2019 Apr 11. Epub 2019 Apr 11.

With the advancement of electrode and equipment technology, neuroprosthetics have become a promising alternative to partially compensate for the loss of sensorimotor function in amputees and patients with neurological diseases. Cortical neural interfaces are suitable especially for spinal cord injuries and amyotrophic lateral sclerosis. Although considerable success has been achieved in the literature by spike decoding of motor signáis from the human brain, somatosensory feedback is essential for better motor control, interaction with objects, and the embodiment of prosthetic devices. Read More

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https://ieeexplore.ieee.org/document/8688479/
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http://dx.doi.org/10.1109/TNSRE.2019.2910320DOI Listing
April 2019
2 Reads

Mental imagery training for treatment of central neuropathic pain: a narrative review.

Acta Neurol Belg 2019 Apr 15. Epub 2019 Apr 15.

Amity Institute of Neuropsychology and Neurosciences (AINN), Amity University UP, Room No. 222A, J1 Block, Sector 125, Noida, 201303, India.

Mental imagery is a quasi-perceptual experience in the absence of external stimuli. This concept has intrigued psychologists, sportspersons, neurologists and other scientists for over a decade now. Imagery has been used in rehabilitation and the results have been promising. Read More

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http://link.springer.com/10.1007/s13760-019-01139-x
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http://dx.doi.org/10.1007/s13760-019-01139-xDOI Listing
April 2019
2 Reads

Role of the BDNF-TrkB pathway in KCC2 regulation and rehabilitation following neuronal injury: A mini review.

Neurochem Int 2019 Apr 12;128:32-38. Epub 2019 Apr 12.

Department of Rehabilitation Sciences, Graduate School of Medicine, Nagoya University, 1-1-20, Daiko-minami Higashi-ku, Nagoya-shi, Aichi, 461-8673, Japan. Electronic address:

In most mature neurons, low levels of intracellular Cl concentrations ([Cl]) are maintained by channels and transporters, particularly the K-Cl cotransporter 2 (KCC2), which is the only Cl extruder in most neurons. Recent studies have implicated KCC2 expression in the molecular mechanisms underlying neuronal disorders, such as spasticity, epilepsy and neuropathic pain. Alterations in KCC2 expression have been associated with brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase B (TrkB). Read More

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http://dx.doi.org/10.1016/j.neuint.2019.04.003DOI Listing
April 2019
1 Read

Mechanisms of noradrenergic modulation of synaptic transmission and neuronal excitability in ventral horn neurons of the rat spinal cord.

Neuroscience 2019 Apr 13. Epub 2019 Apr 13.

Division of Anesthesiology, Niigata University Graduate School of Medical and Dental Sciences, Asahimachidori 1-757, Chuo-ku, Niigata-city, 951-8510, Japan; Department of Anesthesiology, Tohoku Medical and Pharmaceutical University, Fukumuro 1-12-1, Miyagino-ku, Sendai-city, 983-8512, Japan. Electronic address:

Noradrenaline (NA) modulates the spinal motor networks for locomotion and facilitates neuroplasticity, possibly assisting neuronal network activation and neuroplasticity in the recovery phase of spinal cord injuries. However, neither the effects nor the mechanisms of NA on synaptic transmission and neuronal excitability in spinal ventral horn (VH) neurons are well characterized, especially in rats aged 7 postnatal days or older. To gain insight into NA regulation of VH neuronal activity, we used a whole-cell patch-clamp approach in late neonatal rats (postnatal day 7-15). Read More

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http://dx.doi.org/10.1016/j.neuroscience.2019.03.026DOI Listing

Spinal Subarachnoid Hemorrhage Induced Intractable Miotic Pupil: A reminder of Ciliospinal Sympathetic Center Ischemia Based Miosis: Experimental Study.

Turk Neurosurg 2018 Oct 27. Epub 2018 Oct 27.

Ataturk University, Faculty of Medicine.

Aim: Although basic pupillodilatatory function of ciliospinal center is well known, neuropathological mechanism of permanent miosis has not been adequately investigated in ciliospinal center pathologies. In this study, ischemic neurodegeneration of ciliospinal center on permanent miosis examined following SAH.

Material And Methods: 19 rabbits were examined in this study. Read More

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http://dx.doi.org/10.5137/1019-5149.JTN.24446-18.1DOI Listing
October 2018
1 Read

The effect of family-centered education on the quality of life of adolescents with spinal cord injuries.

J Family Med Prim Care 2019 Feb;8(2):711-716

Department of Biostatistics, School of Management and Medical Informatics, Iran University of Medical Sciences, Tehran, Iran.

Background And Purpose: Spinal injury is a destructive complication creating huge changes in the teen health and lifestyle, depending on its extent and severity. Although most of the complications of this disease are treatable, they impose huge costs on the healthcare system, the patient, and his family. The present study was conducted to investigate the effect of family-centered education on the quality of life and self-esteem of adolescents with spinal cord injuries. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_305_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436315PMC
February 2019

Multimodality Intraoperative Neuromonitoring in Severe Thoracic Deformity PVCR Correction.

World Neurosurg 2019 Apr 11. Epub 2019 Apr 11.

Spine Center, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China. Electronic address:

Background: Multimodal intraoperative neuromonitoring (IONM) has been proposed as an effective way to reduce permanent neurologic injury during spinal deformity surgery. However, few studies have reported evoked potential changes at different surgical stages of thoracic posterior vertebral column resection (PVCR).

Methods: A total of 82 cases with severe thoracic deformity (Yang's A type) treated by PVCR in a single institution between January 2010 and March 2015 were reviewed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193081
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http://dx.doi.org/10.1016/j.wneu.2019.03.140DOI Listing
April 2019
2 Reads

Evaluation of MoPyC-prosthesis implantation and the use of angular stable plates in the treatment of comminuted radial head fractures.

J Orthop 2019 Jul-Aug;16(4):288-293. Epub 2019 Mar 21.

ATORG - Aschaffenburg Trauma and Orthopaedic Research Group, Center for Trauma Surgery, Orthopaedics and Sports Medicine, Hospital Aschaffenburg-Alzenau, Am Hasenkopf 1, D-63739, Aschaffenburg, Germany.

Objective: Comminuted radial head fractures are disproportionately often accompanied by injuries of the bone or ligaments and can be treated in different ways.

Methods: 15 patients with a comminuted radial head fracture were treated with an angular stable plate (=G1) and 8 with a MoPyC-prosthesis (=G2).

Results: G1 shows an average Morrey-score of 83,87 points. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0972978X193016
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http://dx.doi.org/10.1016/j.jor.2019.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441677PMC
March 2019
2 Reads

Evaluation of MoPyC-prosthesis implantation and the use of angular stable plates in the treatment of comminuted radial head fractures.

J Orthop 2019 Jul-Aug;16(4):269-274. Epub 2019 Mar 25.

ATORG - Aschaffenburg Trauma and Orthopaedic Research Group, Center for Trauma Surgery, Orthopaedics and Sports Medicine, Hospital Aschaffenburg-Alzenau, Am Hasenkopf 1, D-63739 Aschaffenburg, Germany.

Objective: Comminuted radial head fractures are disproportionately often accompanied by injuries of the bone or ligaments and can be treated in different ways.

Methods: 15 patients with a comminuted radial head fracture were treated with an angular stable plate (=G1) and 8 with a MoPyC-prosthesis (=G2)

Results: G1 shows an average Morrey-score of 83,87 points. Complications occurred in 5/15 patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0972978X183056
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http://dx.doi.org/10.1016/j.jor.2019.02.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441706PMC
March 2019
1 Read

Labour market attachment after mild traumatic brain injury: nationwide cohort study with 5-year register follow-up in Denmark.

BMJ Open 2019 Apr 11;9(4):e026104. Epub 2019 Apr 11.

Department of Psychology, University of Copenhagen, Copenhagen, Denmark.

Objectives: Sickness absence after mild traumatic brain injury (mTBI) is frequent due to postconcussive symptoms. We examined labour market attachment following mTBI up to 5 years postinjury.

Design And Setting: Nationwide cohort study with register follow-up. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026104DOI Listing
April 2019
1 Read

SponDT (Spondylodiscitis Diagnosis and Treatment): spondylodiscitis scoring system.

J Orthop Surg Res 2019 Apr 11;14(1):100. Epub 2019 Apr 11.

Clinic of Trauma Hand- und Reconstructive Surgery, Friedrich-Schiller-University Jena, Jena, Germany.

Background: Spondylodiscitis is a chameleon among infectious diseases due to the lack of specific symptoms with which it is associated. It is nevertheless a serious infection, with 7% mortality of hospitalized patients, in large part because of delayed diagnosis. The aim of this study was to develop a diagnosis and course-of-disease index to optimize its treatment. Read More

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http://dx.doi.org/10.1186/s13018-019-1134-9DOI Listing

Progression of local kyphosis after conservative treatment for compressive cervical spine fracture with spinal cord injury.

J Orthop Surg Res 2019 Apr 11;14(1):98. Epub 2019 Apr 11.

Departments of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashiku, Fukuoka, 812-8582, Japan.

Introduction: Compressive-flexion type cervical spine fracture is typically accompanied by apparent dislocation of the facet joints, undesirable cervical alignment, and devastating neurological dysfunction, which provides strong rationale for rendering prompt operative treatment. However, the validity of conservative treatment for compressive-flexion cervical spine injury in cases with preserved congruity of the facet joints has yet to be elucidated. The purpose of this study is to evaluate the long-term outcome of cervical alignment following conservative treatment for compressive-flexion cervical spine injury with preserved congruity of the facet joints. Read More

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http://dx.doi.org/10.1186/s13018-019-1115-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458645PMC

Fibroadhesive scarring of grafted collagen scaffolds interferes with implant-host neural tissue integration and bridging in experimental spinal cord injury.

Regen Biomater 2019 Mar 4;6(2):75-87. Epub 2019 Feb 4.

Institute of Neuropathology, RWTH Aachen University Hospital, Aachen, Germany.

Severe traumatic spinal cord injury (SCI) results in a devastating and permanent loss of function, and is currently an incurable condition. It is generally accepted that future intervention strategies will require combinational approaches, including bioengineered scaffolds, to support axon growth across tissue scarring and cystic cavitation. Previously, we demonstrated that implantation of a microporous type-I collagen scaffold into an experimental model of SCI was capable of supporting functional recovery in the absence of extensive implant-host neural tissue integration. Read More

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http://dx.doi.org/10.1093/rb/rbz006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447003PMC
March 2019
1 Read

The Overlooked Outcome Measure for Spinal Cord Injury: Use of Assistive Devices.

Front Neurol 2019 22;10:272. Epub 2019 Mar 22.

Spinal Cord Unit, IRCCS Fondazione Santa Lucia, Rome, Italy.

Although several outcome measures are used to assess various areas of interest regarding spinal cord injuries (SCIs), little is known about the frequency of their use, and the ways in which they transform shared knowledge into implemented practices. Herein, 800 professionals from the International Spinal Cord Society, especially trained for caring in patients with SCI, were invited to respond to an Internet survey collecting information on the use of standardized measures in daily clinical practices. We asked both clinicians and researchers with different areas of interest about their use of functional outcome measures, and, in particular, which scales they habitually use to assess various aspects of clinical practice and rehabilitation. Read More

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http://dx.doi.org/10.3389/fneur.2019.00272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438886PMC
March 2019
1 Read

Results of interviews with families of non-heart-beating donor candidates.

Emergencias 2019 Abr;31(2):143-144

Oficina Regional de Coordinación de Trasplantes. Consejería de Sanidad. Comunidad de Madrid, España.

Objectives: To measure cervical spine movement during removal of a motorcycle helmet by health care professionals.

Material And Methods: Observational study using biomechanical inertial sensors to detect movement in the spinal column during removal of helmets.

Results: Thirty-four emergency medicine specialists and nurses participated. Read More

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April 2019
1 Read

Effect of corporal suspension and pendulum exercises on neuromuscular properties and functionality in patients with medullar thoracic injury.

Clin Biomech (Bristol, Avon) 2019 Mar 23;63:214-220. Epub 2019 Feb 23.

Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.

Background: Traumatic spinal cord injury (TSCI) is one of the most devastating injuries that has a physical impact on patients. The CHORDATA® method involves suspension and pendulous exercises and has been clinically used to treat patients with TSCI. Although empirically used to treat neurological patients, there is no scientific evidence of the efficacy of this method. Read More

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http://dx.doi.org/10.1016/j.clinbiomech.2019.02.012DOI Listing
March 2019
8 Reads

Development of a Traumatic Cervical Dislocation Spinal Cord Injury Model with Residual Compression in the Rat.

J Neurosci Methods 2019 Apr 2. Epub 2019 Apr 2.

Orthopaedic and Injury Biomechanics Group, Departments of Orthopaedics and Mechanical Engineering, International Collaboration on Repair Discoveries, University of British Columbia, 818 West 10th Avenue, Vancouver, BC, V5Z 1M9, Canada. Electronic address:

Background: Pre-clinical spinal cord injury models do not represent the wide range of biomechanical factors seen in human injuries, such as spinal level, injury mechanism, velocity of spinal cord impact, and residual compression. These factors may be responsible for differences observed between experimental and clinical study results, especially related to the controversial issue of timing of surgical decompression.

New Method: Somatosensory Evoked Potentials were used to: a) characterize residual compression depths in a dislocation model, and b) evaluate the physiological effect of whether or not the spinal cord was decompressed following the initial injury, prior to the application of residual compression. Read More

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http://dx.doi.org/10.1016/j.jneumeth.2019.03.010DOI Listing
April 2019
1 Read

Neuroprotective effects of allopurinol on spinal cord injury in rats: a biochemical and immunohistochemical study.

Folia Morphol (Warsz) 2019 Apr 5. Epub 2019 Apr 5.

Department of Histology and Embryology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.

Lesion in spinal cord causes a cascade of events such as the apoptosis of neurons and eventually, neurological dysfunction. Neurologic damage developing after acute spinal cord injury is also related with necrosis and free radical formation. Allopurinol a xanthine oxidase inhibitor, was shown to have protective effects in several studies. Read More

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http://dx.doi.org/10.5603/FM.a2019.0036DOI Listing
April 2019
3 Reads

The Effect of Non-Gabapentinoid Anticonvulsants on Sensorimotor Recovery After Human Spinal Cord Injury.

CNS Drugs 2019 Apr 4. Epub 2019 Apr 4.

School of Kinesiology, University of British Columbia, Vancouver, BC, Canada.

Background: Recent observational studies have shown an association between gabapentinoid anticonvulsants and greater motor recovery after spinal cord injury. There is preclinical evidence to suggest that other anticonvulsants, such as sodium channel blockers, may also confer beneficial effects.

Purpose: The aim of the current study was to determine if non-gabapentinoid anticonvulsants were associated with neurological recovery after acute, traumatic spinal cord injury. Read More

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http://dx.doi.org/10.1007/s40263-019-00622-6DOI Listing

Expression of miR-210 mediated by adeno-associated virus performed neuroprotective effects on a rat model of acute spinal cord injury.

Tissue Cell 2019 Apr 10;57:22-33. Epub 2019 Feb 10.

Department of Orthopaedics, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157, Xiwu Road, Xi'an, Shaanxi, 710004, China. Electronic address:

Acute spinal cord injuries (ASCI) are common neural disorders in traumatology medicine. MicroRNA-210 (miR-210) plays a crucial role in cell survival, endothelial cell migration and cell regeneration. This paper is aim to validate the pathophysiological function of miR-210 on ASCI. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00408166183033
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http://dx.doi.org/10.1016/j.tice.2019.02.004DOI Listing
April 2019
4 Reads

Burn on the buttocks caused by gel wheelchair cushion left on driver's seat of hand control car.

J Spinal Cord Med 2019 Apr 4:1-3. Epub 2019 Apr 4.

a Department of Plastic and Reconstructive Surgery , Ogaki Municipal Hospital , Ogaki City , Japan.

Context: Nowadays, people with paraplegia and quadriplegia have greater opportunities to venture into the general public. However, there is also an increased risk of associated hazards.

Findings: This report describes a 42-year-old man with paraplegia, who was insensate below the T7 level and sustained burns from sitting on a gel wheelchair cushion that had been left on the driver-side seat of a hand control car on a sunny day. Read More

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http://dx.doi.org/10.1080/10790268.2019.1599540DOI Listing
April 2019
1 Read

Correction: A Multidisciplinary Model to Guide Employment Outcomes Among People Living With Spinal Cord Injuries in South Africa: A Mixed Methods Study Protocol.

JMIR Res Protoc 2019 Apr 3;8(4):e13026. Epub 2019 Apr 3.

Department of Public Health Medicine, School of Nursing and Public Health, University of KwaZulu-Natal, Durban, South Africa.

[This corrects the article DOI: 10.2196/resprot.5887. Read More

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http://dx.doi.org/10.2196/13026DOI Listing
April 2019
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Motor demands of cognitive testing may artificially reduce executive function scores in individuals with spinal cord injury.

J Spinal Cord Med 2019 Apr 3:1-9. Epub 2019 Apr 3.

a Department of Physical Therapy and Rehabilitation Science , Roy J. and Lucille A. Carver College of Medicine, University of Iowa , Iowa City , Iowa , USA.

Objective: To determine whether the motor demands of cognitive tests contribute to differences in cognitive function scores in participants with and without spinal cord injury (SCI).

Design: Cohort study.

Setting: Rehabilitation research laboratory. Read More

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http://dx.doi.org/10.1080/10790268.2019.1597482DOI Listing
April 2019
1 Read

Traumatic vs non-traumatic spinal cord injury: A comparison of primary rehabilitation outcomes and complications during hospitalization.

J Spinal Cord Med 2019 Apr 3:1-7. Epub 2019 Apr 3.

c Department of Neurology , Haukeland University Hospital , Bergen , Norway.

Objective: To compare outcome for patients with traumatic (TSCI) and non-traumatic spinal cord injuries (NTSCI) after primary rehabilitation regarding neurological improvement measured by the American Spinal Injury Association Impairment Scale (AIS), length of stay and complications.

Design: Retrospective comparative cohort study on patients with TSCI and NTSCI, hospitalized during a ten-year period at Haukeland University Hospital, Norway. Impairment, length of stay and complications during first in-patient rehabilitation period were analyzed. Read More

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http://dx.doi.org/10.1080/10790268.2019.1598698DOI Listing
April 2019
1 Read

The Application of Omics Technologies to Study Axon Regeneration and CNS Repair.

F1000Res 2019 20;8. Epub 2019 Mar 20.

Center for Brain and Spinal Cord Repair, Institute for Behavioral Medicine Research, Ohio State University, Columbus, Ohio, 43210, USA.

Traumatic brain and spinal cord injuries cause permanent disability. Although progress has been made in understanding the cellular and molecular mechanisms underlying the pathophysiological changes that affect both structure and function after injury to the brain or spinal cord, there are currently no cures for either condition. This may change with the development and application of multi-layer omics, new sophisticated bioinformatics tools, and cutting-edge imaging techniques. Read More

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http://dx.doi.org/10.12688/f1000research.17084.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429978PMC
March 2019
1 Read

Development of a Multimodal Apparatus to Generate Biomechanically Reproducible Spinal Cord Injuries in Large Animals.

Front Neurol 2019 19;10:223. Epub 2019 Mar 19.

Norwegian Center for Stem Cell Research, Oslo University Hospital, Oslo, Norway.

Rodents are widespread animal models in spinal cord injury (SCI) research. They have contributed to obtaining important information. However, some treatments only tested in rodents did not prove efficient in clinical trials. Read More

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http://dx.doi.org/10.3389/fneur.2019.00223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433700PMC

Development of Clinical Tracheostomy Score to Identify Cervical Spinal Cord Injury Patients Requiring Prolonged Ventilator Support.

J Trauma Acute Care Surg 2019 Apr 1. Epub 2019 Apr 1.

Hahnemann University Hospital, Philadelphia, PA 19102.

Objectives: Cervical spinal cord injuries (CSCI) often necessitate ventilator support (VS). Prolonged endotracheal tube use has conveyed substantial morbidity in prospective study. Tracheostomy is recommended if VS is anticipated to be ≥7 days, which defines prolonged ventilation (PV). Read More

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http://dx.doi.org/10.1097/TA.0000000000002286DOI Listing
April 2019
3 Reads
1.970 Impact Factor

Posterior cord syndrome: Demographics and rehabilitation outcomes.

J Spinal Cord Med 2019 Apr 2:1-6. Epub 2019 Apr 2.

b Department of Biostatistics , Virginia Commonwealth University Health Systems , Richmond , Virginia , USA.

Context/Objectives: To describe demographics, clinical characteristics, and functional outcomes of patients with incomplete spinal cord injuries and posterior cord syndrome (PCS).

Design: Five-year retrospective case series.

Setting: Spinal cord injury (SCI) rehabilitation unit at a Level 1 tertiary university medical center. Read More

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http://dx.doi.org/10.1080/10790268.2019.1585135DOI Listing
April 2019
3 Reads

Breech delivery, rupture of Batson's plexus, T8 epidural hematoma, and paraplegia.

J Neonatal Perinatal Med 2019 Mar 29. Epub 2019 Mar 29.

Creighton University School of Medicine Phoenix Regional Campus, St Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.

A male newborn born by an atraumatic vaginal frank breech delivery was noted to have normal limb movement at birth. However, at 24 hours the neonate developed paraplegia with no evidence of spinal cord injury on radiographic films. Ultrasound and MRI demonstrated an epidural hematoma at the level of T8 and distal cord edema which extended to the conus medullaris. Read More

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http://dx.doi.org/10.3233/NPM-180080DOI Listing
March 2019
2 Reads

[Spanish validation of the Autonomic Standards Assessment Form in spinal cord injuries].

Rehabilitacion (Madr) 2019 Jan - Mar;53(1):20-27. Epub 2018 Dec 7.

Unidad de Lesionados Medulares, Área de Rehabilitación, Hospital Universitario Vall d'Hebron, Universidad Autónoma de Barcelona, Barcelona, España.

Introduction And Objectives: Autonomic nervous system (ANS) dysfunction in patients with spinal cord injury (SCI) severely impacts morbidity and mortality. However, research initiatives aiming to gain insight into the direct impact of ANS dysfunction on health outcomes in persons with SCI are still lacking. Thus, this study had 2main objectives: 1) to translate into Spanish the revised edition of the International Standards on documentation of remaining Autonomic Function after SCI (ISAFSCI), and 2) to describe the impact of ANS dysfunction in a sample of SCI patients. Read More

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http://dx.doi.org/10.1016/j.rh.2018.10.007DOI Listing
December 2018
2 Reads

Aortic reinterventions after the frozen elephant trunk procedure.

J Thorac Cardiovasc Surg 2019 Feb 28. Epub 2019 Feb 28.

Department of Cardiovascular Surgery, University Heart Center Freiburg, Freiburg, Germany; Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Objective: The frozen elephant trunk (FET) procedure has emerged as a potential single-step treatment for pathologies of the thoracic aorta, but the procedure's true potential to be a single-step treatment remains unclear. The aim of this study was to evaluate the need and outcomes of aortic reinterventions after previous FET implantation.

Methods: Patient characteristics and follow-up data of 107 patients following the FET procedure were evaluated and compared between patients with and without aortic reinterventions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00225223193051
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http://dx.doi.org/10.1016/j.jtcvs.2019.02.069DOI Listing
February 2019
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Multifunctionalized hydrogels foster hNSC maturation in 3D cultures and neural regeneration in spinal cord injuries.

Proc Natl Acad Sci U S A 2019 Apr 28;116(15):7483-7492. Epub 2019 Mar 28.

Unità Ingegneria Tissutale, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Casa Sollievo della Sofferenza, 71013 Foggia, Italy;

Three-dimensional cell cultures are leading the way to the fabrication of tissue-like constructs useful to developmental biology and pharmaceutical screenings. However, their reproducibility and translational potential have been limited by biomaterial and culture media compositions, as well as cellular sources. We developed a construct comprising synthetic multifunctionalized hydrogels, serum-free media, and densely seeded good manufacturing practice protocol-grade human neural stem cells (hNSC). Read More

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http://dx.doi.org/10.1073/pnas.1818392116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462084PMC

Racial/Ethnic Differences in Obesity in People with Spinal Cord Injury: The Effects of Disadvantaged Neighborhood.

Arch Phys Med Rehabil 2019 Mar 25. Epub 2019 Mar 25.

Department of Physical Medicine and Rehabilitation, University of Alabama at Birmingham, Birmingham, AL. Electronic address:

Objective: To examine the role of neighborhood in the relationship between race and obesity in people with spinal cord injury (SCI).

Design: A cross-sectional analysis of survey data from National SCI Database linked with neighborhood data from American Community Survey by census tract.

Setting: 17 SCI Model Systems centers. Read More

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http://dx.doi.org/10.1016/j.apmr.2019.02.008DOI Listing

Implementation and results of a practical grading system for thoracic blunt aortic injury.

J Vasc Surg 2019 Mar 25. Epub 2019 Mar 25.

Division of Vascular Surgery, Department of Surgery, University of Washington, Seattle, Wash.

Objective: We previously proposed a grading system for blunt thoracic aortic injury (BTAI) designed to guide therapy. This study analyzed our outcomes since implementing this system.

Methods: A single-center, retrospective study was conducted of consecutive patients presenting with BTAI between January 2014 and December 2017. Read More

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http://dx.doi.org/10.1016/j.jvs.2019.01.048DOI Listing
March 2019
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Prevention care for secondary health conditions among people living with spinal cord injuries: research protocol.

BMC Res Notes 2019 Mar 28;12(1):179. Epub 2019 Mar 28.

Department of Physiotherapy, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Johannesburg, 2193, South Africa.

Objective: People living with spinal cord injuries are at a high risk to experience preventable secondary health conditions in their lifetime, which can lead to rehospitalisation and death. Given the fact that spinal cord injury is a long term disability requiring on-going care, there is need to strengthen prevention of secondary health conditions. This study aims to establish factors influencing prevention care for secondary health conditions among people living with spinal cord injuries in a metropolitan area in order to develop a prevention model of care. Read More

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http://dx.doi.org/10.1186/s13104-019-4202-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437883PMC

[Anterior versus posterior decompression for the treatment of thoracolumbar fractures with spinal cord injury:a Meta-analysis].

Zhongguo Gu Shang 2019 Mar;32(3):269-277

Department of Orthopaedics, the Second Hospital of Lanzhou University, Lanzhou 730000, Gansu, China;

Objective: To systematically evaluate the efficacy and safety of anterior decompression and posterior decompression in the treatment of thoracolumbar fractures with spinal cord injury, so as to provide a good scientific basis for more effective treatment of thoracolumbar fractures with spinal cord injury.

Methods: A clinical data about comparative study of anterior decompression and posterior decompression in the treatment of thoracolumbar fractures with spinal cord injury was searched and collected. The databases of Pubmed, Embase, Cochrane Library, CNKI, CBM, Wanfang Medical Network were searched by computer. Read More

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http://dx.doi.org/10.3969/j.issn.1003-0034.2019.03.015DOI Listing

Preliminary psychometric analyses of the International Spinal Cord Injury Quality of Life Basic Data Set.

Spinal Cord 2019 Mar 27. Epub 2019 Mar 27.

Center of Excellence for Rehabilitation Medicine, Brain Center, Rudolf Magnus, University Medical Center Utrecht, University Utrecht and De Hoogstraat Rehabilitation, Utrecht, The Netherlands.

Study Design: Secondary psychometric analysis of cross-sectional previously collected data.

Objectives: Explore the floor and ceiling effects, convergent, and divergent validity of the International Spinal Cord Injury Basic Quality of Life Data Set (SCI QoL-BDS) in a sample of people with spinal cord damage (SCD) from different countries, with different causes (both traumatic and non-traumatic), and different settings.

Setting: Community dwellers with SCD in Australia, Brazil, India, The Netherlands, and USA, and inpatient rehabilitation: India. Read More

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http://dx.doi.org/10.1038/s41393-019-0273-5DOI Listing

Cognitive, Emotional, and Physical Functioning as Predictors of Paid Employment in People With Stroke, Traumatic Brain Injury, and Spinal Cord Injury.

Am J Occup Ther 2019 Mar/Apr;73(2):7302205010p1-7302205010p15

Allen W. Heinemann, PhD, ABPP-RP, FACRM, is Professor, Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago, and Director, Center for Rehabilitation Outcomes Research, Shirley Ryan AbilityLab, Chicago.

Objective: Our objective was to examine demographic, cognitive, emotional, and physical factors that predict return to paid employment for people after neurological injury.

Method: Four hundred eighty adults with stroke (n = 149), traumatic brain injury (n = 155), and spinal cord injury (n = 176) completed an occupational outcome questionnaire and physical, emotional, and cognitive assessments at three rehabilitation facilities.

Results: Odds of employment were predicted by being married or partnered, having more education, requiring fewer prompts for task sequencing, and having higher inhibitory control (but were not predicted by specific type of injury). Read More

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http://dx.doi.org/10.5014/ajot.2019.031203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436116PMC

The impact of stenosis and translation on spinal cord injuries in traumatic cervical facet dislocations.

Spine J 2019 Apr 25;19(4):687-694. Epub 2018 Oct 25.

Department of Orthopaedic Surgery and Sports Medicine, Harborview Medical Center, 325 Ninth Avenue, Box 359798, Seattle, WA 98104, USA. Electronic address:

Background Context: Although facet dislocations account for only 6% of cervical trauma, the consequences are often devastating. Cervical facet dislocations are associated with a disproportionate amount of spinal cord injuries; however, neurologic examination of patients is often difficult, as patients commonly present with reduced levels of consciousness. There are limited studies that have investigated the impact of spinal canal diameter and translation on neurologic injury following facet dislocations. Read More

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http://dx.doi.org/10.1016/j.spinee.2018.10.015DOI Listing
April 2019
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Effects of Dopamine on Motor Recovery and Training in Adults and Children With Nonprogressive Neurological Injuries: A Systematic Review.

Neurorehabil Neural Repair 2019 Mar 27:1545968319837289. Epub 2019 Mar 27.

1 National Institutes of Health, Bethesda, MD, USA.

Background: The strong link between dopamine and motor learning has been well-established in the animal literature with similar findings reported in healthy adults and the elderly.

Objective: We aimed to conduct the first, to our knowledge, systematic review of the literature on the evidence for the effects of dopaminergic medications or genetic variations in dopamine transmission on motor recovery or learning after a nonprogressive neurological injury.

Methods: A PubMed search was conducted up until April 2018 for all English articles including participants with nonprogressive neurological injury such as cerebral palsy, stroke, spinal cord injury, and traumatic brain injury; quantitative motor outcomes; and assessments of the dopaminergic system or medications. Read More

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http://dx.doi.org/10.1177/1545968319837289DOI Listing
March 2019
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Scaffold-mediated sequential drug/gene delivery to promote nerve regeneration and remyelination following traumatic nerve injuries.

Adv Drug Deliv Rev 2019 Mar 22. Epub 2019 Mar 22.

School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore. Electronic address:

Neural tissue regeneration following traumatic injuries is often subpar. As a result, the field of neural tissue engineering has evolved to find therapeutic interventions and has seen promising outcomes. However, robust nerve and myelin regeneration remain elusive. Read More

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http://dx.doi.org/10.1016/j.addr.2019.03.004DOI Listing

Media: Facingdisability.com: a unique video library reflecting the experiences of people with spinal cord injuries and their families.

Authors:
Joanne Glinsky

J Physiother 2019 Apr 23;65(2):118. Epub 2019 Mar 23.

John Walsh Centre for Rehabilitation Research, University of Sydney; Kolling Institute, Royal North Shore Hospital, Australia.

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http://dx.doi.org/10.1016/j.jphys.2019.02.009DOI Listing

Does pediatric traumatic brain injury cause adult alcohol misuse: Combining preclinical and epidemiological approaches.

Exp Neurol 2019 Mar 22;317:284-290. Epub 2019 Mar 22.

Department of Physical Medicine and Rehabilitation, Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.

Traumatic brain injury (TBI) is closely interrelated with alcohol use disorders. This is mediated, in part, by the large number of individuals who are intoxicated at the time of their injuries. However, there is also evidence, both preclinically and epidemiologically that TBI, particularly when it occurs early in life can increase the incidence of alcohol use disorders later on. Read More

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http://dx.doi.org/10.1016/j.expneurol.2019.03.012DOI Listing
March 2019
4.696 Impact Factor

Knowledge Gaps in Urologic Care of Female Spinal Cord Injury Patients.

Curr Urol Rep 2019 Mar 23;20(5):21. Epub 2019 Mar 23.

Department of Urology, Sidney Kimmel Medical College, Thomas Jefferson University, 1025 Walnut St, Ste 1100, Philadelphia, PA, 19107, USA.

Purpose Of Review: We highlight the substantial gaps in knowledge on urologic care of female spinal cord injury (SCI) patients.

Recent Findings: Males account for approximately 80% of people living with SCI in developed nations. Although there is a robust body of literature in some aspects of urologic care of individuals with SCI, such as treatments for neurogenic detrusor overactivity, there are relatively few studies focusing specifically on females. Read More

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http://dx.doi.org/10.1007/s11934-019-0884-6DOI Listing
March 2019
1 Read