9,573 results match your criteria Spinal Cord Infections


Botulinum Neurotoxin Light Chains Expressed by Defective Herpes Simplex Virus Type-1 Vectors Cleave SNARE Proteins and Inhibit CGRP Release in Rat Sensory Neurons.

Toxins (Basel) 2019 Feb 19;11(2). Epub 2019 Feb 19.

UMR U1179 INSERM/Université de Versailles Saint Quentin en Yvelines (UVSQ)-Paris Saclay, 78180 Montigny-le-Bretonneux, France.

A set of herpes simplex virus type 1 (HSV-1) amplicon vectors expressing the light chains (LC) of botulinum neurotoxins (BoNT) A, B, C, D, E and F was constructed. Their properties have been assessed in primary cultures of rat embryonic dorsal root ganglia (DRG) neurons, and in organotypic cultures of explanted DRG from adult rats. Following infection of primary cultures of rat embryonic DRG neurons, the different BoNT LC induced efficient cleavage of their corresponding target Soluble N-ethylmaleimide-sensitive-factor Attachment protein Receptor (SNARE) protein (VAMP, SNAP25, syntaxin). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/toxins11020123DOI Listing
February 2019

Intraventricular empyema caused by .

IDCases 2019 5;15:e00503. Epub 2019 Feb 5.

Department of Internal Medicine, Quinnipiac University Frank H. Netter MD School of Medicine/Saint Vincent's Medical Center, Bridgeport, CT, USA.

Meningitis is defined as an inflammation of the protective covering of brain and spinal cord collectively called as meninges. Meningeal infection can be complicated by intraventricular empyema. There are 9 cases of intraventricular empyema described in the literature out of which only three are described to be caused by . Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.idcr.2019.e00503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369236PMC
February 2019

Chinese expert consensus on the treatment of modern combat-related spinal injuries.

Mil Med Res 2019 Feb 20;6(1). Epub 2019 Feb 20.

Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.

The battlefield treatments of spinal and spinal cord injury vary from civilian settings. However, there is no unified battlefield treatment guidelines for spine trauma in PLA. An expert consensus is reached, based on spine trauma epidemiology and the concepts of battlefield treatment combined with the existing levels of military medical care in modern warfare. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40779-019-0196-7DOI Listing
February 2019

Antibiotic prophylaxis prior to urodynamic study in patients with traumatic spinal cord injury. Is there an indication?

Int Braz J Urol 2019 Feb 10;45. Epub 2019 Feb 10.

Serviço de Lesão Medular, Rede Sarah de Hospitais de Reabilitação, Brasília, DF, Brasil.

Study Design: Retrospective cohort of patients with traumatic spinal cord injury (SCI) that have been hospitalized for physical-functional rehabilitation purposes.

Objectives: To compare the incidence of urinary tract infection (UTI) after urodynamic study (UDS) in three hospitals that adopted different protocols with regard to the preparation of patients.

Setting: Sarah Network of Rehabilitation Hospitals, Brazil. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/S1677-5538.IBJU.2018.0574DOI Listing
February 2019

Tetraplegia associated with post-operative syringomyelia in spinal tuberculosis: a result of an epidural compartment syndrome?

Spinal Cord Ser Cases 2019 12;5:18. Epub 2019 Feb 12.

Department of Orthopaedics, Max Smart Super Specialty Hospital, New Delhi, India.

Introduction: The commonly recognized causes of post-operative neurological deterioration in spinal tuberculosis are inadequate decompression, damage to vascular supply of the spinal cord, and multi-drug resistant organisms. There are no known cases of syringomyelia developing after surgical decompression of spinal tuberculosis.

Case Presentation: A teenage girl presented with rapid onset quadriparesis secondary to a tubercular epidural abscess extending from C4-T8. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41394-019-0159-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372701PMC
February 2019

RADIOACTIVE CEMENT OF PMMA AND HAP-Sm-153, Ho-166, OR RE-188 FOR BONE METASTASIS TREATMENT.

Acta Ortop Bras 2019 Jan-Feb;27(1):64-68

Department of Nuclear Engineering, Laboratório Núcleo de Radiações Ionizantes, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.

Polymethylmetacrylte (PMMA) is used in the fields of dentistry and biomedicine as a constituent of bone cements. Hydroxyapatite (HAp) is a bioceramic produced naturally in the bones. PMMA and HAp are fundamental constituents in the preparation of bone cements. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/1413-785220192701190288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362695PMC
February 2019

Comparison of All-Cause and Cause-Specific Mortality of Persons with Traumatic Spinal Cord Injuries to the General Swiss Population: Results from a National Cohort Study.

Neuroepidemiology 2019 Feb 14;52(3-4):205-213. Epub 2019 Feb 14.

Swiss Paraplegic Research, Nottwil, Switzerland.

Background: Traumatic spinal cord injuries (TSCI) are a neurological condition associated with reduced well-being, increased morbidity and reductions in life expectancy. Estimates of all-cause and cause-specific mortality can aid in identifying targets for prevention and management of contributors for premature mortality.

Objectives: To compare all-cause and cause-specific rates of mortality to that of the Swiss general population; to identify differentials in risk of cause-specific mortality according to lesion characteristics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496976DOI Listing
February 2019

Determining Best Practices for Management of Bacteriuria in Spinal Cord Injury: Protocol for a Mixed-Methods Study.

JMIR Res Protoc 2019 Feb 14;8(2):e12272. Epub 2019 Feb 14.

Center for Innovations in Quality, Effectiveness and Safety, Houston, TX, United States.

Background: Bacteriuria, either asymptomatic (ASB) or symptomatic, urinary tract infection (UTI), is common in persons with spinal cord injury (SCI). Current Veterans Health Administration (VHA) guidelines recommend a screening urinalysis and urine culture for every veteran with SCI during annual evaluation, even when asymptomatic, which is contrary to other national guidelines. Our preliminary data suggest that a positive urine culture (even without signs or symptoms of infection) drives antibiotic use. Read More

View Article

Download full-text PDF

Source
https://www.researchprotocols.org/2019/2/e12272/
Publisher Site
http://dx.doi.org/10.2196/12272DOI Listing
February 2019
3 Reads

Brain and Spinal Cord Lesions in Leprosy: A Magnetic Resonance Imaging-Based Study.

Am J Trop Med Hyg 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India.

Neurotropism and infiltration by of peripheral nerves causing neuropathy are well established, but reports of central nervous system (CNS) damage are exceptional. We report CNS magnetic resonance imaging (MRI) abnormalities of the brain and spinal cord as well as lesions in nerve roots and plexus in leprosy patients. Eight patients aged between 17 and 41 years underwent detailed clinical, histopathological, and MRI evaluation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4269/ajtmh.17-0945DOI Listing
February 2019
3 Reads
2.699 Impact Factor

Continuous Bilateral Erector of Spine Plane Block at T8 for Extensive Lumbar Spine Fusion Surgery: Case report.

Pain Pract 2019 Feb 13. Epub 2019 Feb 13.

Tondela Viseu Hospital Centre, Anesthesiology Service.Address: Centro Hospitalar Tondela Viseu, Anesthesiology Service, Serviço de Anestesiologia Rua Rei Dom Duarte, 3504-509, Viseu, Portugal.

Supplementary strategies, in combination with conventional analgesia, for pain control after lumbar fusion surgery remain limited. Here, we describe a 79-year-old woman who experienced pain (10/10 on a numerical rating scale) on post-operative day 1 after undergoing L2 to S1 spine fusion. Erector spinae plane (ESP) blocks were performed at T8 and, after a bolus of ropivacaine 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/papr.12774DOI Listing
February 2019
1 Read

Acute idiopathic spinal subdural hematoma: What to do in an emergency?

Neurochirurgie 2019 Feb 8. Epub 2019 Feb 8.

Department of neurosurgery, Sainte Anne Military Hospital, France. Electronic address:

Acute spinal cord compression usually results from trauma, infection, or cancer. Spinal subdural hematoma is an uncommon cause of spinal cord compression that occurs after spine trauma or spinal invasive procedure, especially in context of coagulopathy. In the following reported case, an 82-year-old woman with a history of rapidly progressive paraparesis after a sudden middle back pain, with no previous trauma or coagulopathy, due to an acute spontaneous spinal subdural hematoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuchi.2018.10.009DOI Listing
February 2019
1 Read

Infliximab biosimilar for treating neurosarcoidosis: tolerance and efficacy in a retrospective study including switch from the originator and initiation of treatment.

J Neurol 2019 Feb 9. Epub 2019 Feb 9.

Sorbonne Université, Assistance Publique-Hôpitaux de Paris, Service de Médecine Interne 2, Centre National de Référence Maladies Systémiques Rares, Hôpital Pitié-Salpêtrière, 47-83 Boulevard de l'hôpital, 75651, Paris Cedex 13, France.

Objectives: Infliximab is increasingly used to treat neurosarcoidosis. We aimed to determine the efficacy and tolerance of an infliximab biosimilar for treating neurosarcoidosis.

Methods: We conducted a retrospective single-center study to describe the efficacy, safety and immunogenicity of an infliximab biosimilar in neurosarcoidosis patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00415-019-09234-yDOI Listing
February 2019
2 Reads

Finegoldia magna causing intramedullary thoracic spinal cord abscess in an infant.

Anaerobe 2019 Feb 7;56:57-60. Epub 2019 Feb 7.

Pediatric Infectious Diseases Unit, Department of Pediatric, King Saud University Medical City, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Spinal intramedullary abscesses are rare and potentially devastating lesions. Infection is mostly caused by staphylococci. Anaerobes are rare and often polymicrobial. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.anaerobe.2019.02.002DOI Listing
February 2019

Astrocytes in Flavivirus Infections.

Int J Mol Sci 2019 Feb 6;20(3). Epub 2019 Feb 6.

Laboratory of Neuroendocrinology-Molecular Cell Physiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Zaloška 4, 1000 Ljubljana, Slovenia.

Virus infections of the central nervous system (CNS) can manifest in various forms of inflammation, including that of the brain (encephalitis) and spinal cord (myelitis), all of which may have long-lasting deleterious consequences. Although the knowledge of how different viruses affect neural cells is increasing, understanding of the mechanisms by which cells respond to neurotropic viruses remains fragmented. Several virus types have the ability to infect neural tissue, and astrocytes, an abundant and heterogeneous neuroglial cell type and a key element providing CNS homeostasis, are one of the first CNS cell types to get infected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20030691DOI Listing
February 2019
1 Read

MRI reveals segmental distribution of enterovirus lesions in the central nervous system: a probable clinical evidence of retrograde axonal transport of EV-A71.

J Neurovirol 2019 Feb 7. Epub 2019 Feb 7.

Guangzou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, China.

Enterovirus 71 (EV-A71) is a major causative agent for hand, foot, and mouth disease (HFMD), especially severe HFMD characterized by neurologic involvement. The objective of this study is to investigate the relationship between the distribution of neurologic infection and the outcomes of severe HFMD. A total of 139 suspected severe HFMD cases (92 were confirmed as EV-A71 infection) underwent clinical and laboratory diagnosis as well as magnetic resonance imaging (MRI) scans of the nervous system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13365-019-00724-3DOI Listing
February 2019
2 Reads

Pregnancy outcomes in women with spinal cord injuries: a population-based study.

PM R 2019 Feb 6. Epub 2019 Feb 6.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Background: Pregnant women with congenital or acquired spinal cord injury face challenges due to compromised neurological function and mobility; factors that may also affect fetal/infant health. Few studies have examined pregnancy course and longer-term outcomes in this population.

Objective: To assess pregnancy outcomes among women with spinal cord injury, paralysis, or spina bifida using population-based data. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/pmrj.12122
Publisher Site
http://dx.doi.org/10.1002/pmrj.12122DOI Listing
February 2019
2 Reads

Proximal femoral resection and Tensor Fascia Lata flap for recalcitrant trochanteric pressure ulcers.

Spinal Cord Ser Cases 2019 5;5:15. Epub 2019 Feb 5.

2Department of Anaesthesiology and Critical Care, Pt. B.D. Sharma PGIMS, Rohtak-124001 Haryana, India.

Introduction: Trochanteric pressure ulcers (PrUs) are difficult to treat and are often complicated by infection spreading to the hip joint. We review three cases from India where proximal femoral resection and pedicled Tensor Fascia Lata (TFL) flapping was used in the management of infected deep trochanteric ulcers communicating to the hip joint.

Case Presentation: Three patients had a total of four trochanteric PrUs communicating to the hip joint. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41394-019-0157-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363780PMC
February 2019

[Acute myeloid leukemia with sudden onset bilateral lower extremity paralysis caused by disseminated mucormycosis following unrelated bone marrow transplantation].

Rinsho Ketsueki 2019 ;60(1):17-21

Division of Hematology, Ehime Prefectural Central Hospital.

A 63-year-old woman was admitted to our hospital with relapsed acute myeloid leukemia. On day10 after reinduction therapy, she became febrile. Computed tomography on day15 revealed right upper lobe consolidation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.11406/rinketsu.60.17DOI Listing
January 2019
1 Read

From Poly(Alkyl Cyanoacrylate) to Squalene as Core Material to Design Nanomedicines.

J Drug Target 2019 Feb 5:1-54. Epub 2019 Feb 5.

a Institut Galien Paris-Sud, UMR 8612, CNRS, Univ. Paris-Sud, Université Paris-Saclay, Faculté de Pharmacie , 5 rue JB Clément , 92296 Châtenay-Malabry , France.

The present review article covers the most important steps of the pioneering work of Patrick Couvreur and tries to shed light on his outstanding career that has been a source of inspiration for many decades. His discovery of the biodegradable poly(alkyl cyanoacrylate) (PACA) nanoparticles has opened large perspectives in nanomedicine. Indeed, nanoparticles made from different types of PACA monomers have been used in different applications such as the treatment of intracellular infections or the treatment of multidrug resistant hepatocarcinoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1061186X.2019.1579822DOI Listing
February 2019
16 Reads

Imaging of Acute Low Back Pain.

Radiol Clin North Am 2019 Mar 5;57(2):397-413. Epub 2018 Dec 5.

Department of Radiology and Imaging Sciences, University of Utah, 30 North 1900 East, Room 1A71, Salt Lake City, UT 84132, USA. Electronic address:

Acute low back pain, defined as less than 6 weeks in duration, does not require imaging in the absence of "red flags" that may indicate a cause, such as fracture, infection, or malignancy. When imaging is indicated, it is important to rule out a host of abnormalities that may be responsible for the pain and any associated symptoms. A common mnemonic VINDICATE can help ensure a thorough consideration of the possible causes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.rcl.2018.10.001DOI Listing
March 2019
1 Read

Infection Prevention Considerations for Complex Penile Prosthesis Recipients.

Curr Urol Rep 2019 Feb 1;20(3):12. Epub 2019 Feb 1.

Section of Urology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.

Purpose Of Review: The purpose of this review is to critically analyze and summarize recent studies in the area of penile prosthesis surgery outcomes with a focus on infection prevention in high-risk patients.

Recent Findings: Reduction of surgical time in complex prosthesis surgery may reduce infection risk. Concomitant implant surgery is not associated with increased infection risk. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11934-019-0875-7DOI Listing
February 2019
1 Read

Recurrent Encephalopathy with Spinal Cord Involvement: An Atypical Manifestation of Aicardi-Goutières Syndrome.

Ann Indian Acad Neurol 2019 Jan-Mar;22(1):111-115

Division of Neuroradiology and Pediatric Radiology, University of Arkansas For Medical Sciences, Little Rock, Arkansas, USA.

Aicardi-Goutières syndrome (AGS) is a rare, genetic inflammatory disease due to mutations in any of the seven genes discovered to date (, and ). Clinical onset is seen most commonly or in infancy; irritability, feeding difficulties, jitteriness, microcephaly, abnormal movements, seizures, bone marrow suppression, and liver dysfunction are seen either during the neonatal age group or within the first few months of life with abrupt onset of neurologic regression and slowing of head growth. Diffusely abnormal white matters with swelling of frontal or temporal lobes, cerebral atrophy, and intracranial calcification are typical neuroradiologic abnormalities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/aian.AIAN_12_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327704PMC
January 2019
2 Reads

Community acquired Stenotrophomonas maltophilia discitis: Diagnosis aided by shotgun metagenomic sequencing.

Int J Infect Dis 2019 Jan 23;81:1-3. Epub 2019 Jan 23.

Zhejiang-California International Nanosystems Institute, Zhejiang University, Hangzhou, China; Department of Pathology and Laboratory Medicine, UCLA School of Medicine, Los Angeles, CA, USA. Electronic address:

We report a rare case of culture negative L4-L5 discitis and epidural abscess in an immunocompetent child who had dry cupping therapy performed to treat low back strain. The causative pathogen was identified as Stenotrophomonas maltophilia by shotgun metagenomic sequencing of spinal cord aspirate after more than one month of unsuccessful empirical treatment with 6 different antibiotics. The patient was successfully treated with Sulfamethoxazole-trimethoprim and minocycline. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S12019712193004
Publisher Site
http://dx.doi.org/10.1016/j.ijid.2019.01.032DOI Listing
January 2019
6 Reads

coenurosis in Tanzania: a major and under-recognised livestock disease problem in pastoral communities.

Vet Rec 2019 Feb 25;184(6):191. Epub 2019 Jan 25.

Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

A neurological syndrome of small ruminants, known locally as '', has been reported among pastoralist livestock keepers in Tanzania. This study was carried out in four affected pastoral communities to determine the prevalence and associated risk factors, characterise the clinical signs and investigate the aetiology of the syndrome. Questionnaires were administered at all households (n=480) within four study villages. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/vr.105186DOI Listing
February 2019

Acute flaccid myelitis: Case report.

MSMR 2019 Jan;26(1):17-19

In August 2018, the U.S. Centers for Disease Control and Prevention (CDC) noted an increased number of reports of patients in the U. Read More

View Article

Download full-text PDF

Source
January 2019

Hospital based care at home; study protocol for a mixed epidemiological and randomized controlled trial.

Trials 2019 Jan 24;20(1):77. Epub 2019 Jan 24.

Department of Neurology, Haukeland University Hospital, Jonas Lies vei 71, 5053, Bergen, Norway.

Background: Individuals with spinal cord injuries (SCI) are prone to pressure ulcers (PUs) because of the loss of sensorimotor function involved as well as increased skin moisture. Treatment of PU after SCI is complicated, involving different specialties and with need for long-lasting follow-up. This study should identify risk factors for PU after SCI, and find an effective and less time-consuming treatment for the condition among different available methods for follow-up. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13063-019-3185-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346520PMC
January 2019
2 Reads

Acute flaccid myelitis caused by enterovirus D68: Case definitions for use in clinical practice.

Eur J Paediatr Neurol 2019 Jan 11. Epub 2019 Jan 11.

Paediatric Neurosciences, Royal Hospital for Sick Children, Edinburgh, UK; Child Life and Health, University of Edinburgh, Edinburgh, UK.

Acute flaccid myelitis (AFM) was increasingly detected in recent years, coinciding with upsurges of enterovirus D68 (EV-D68) infections. We reviewed the evidence for a causal relationship between both. Based on reported cases, we provide case definitions for AFM caused by EV-D68 infections to enable a standard procedure for affected patients. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10903798183028
Publisher Site
http://dx.doi.org/10.1016/j.ejpn.2019.01.001DOI Listing
January 2019
5 Reads

Facets of Theiler's Murine Encephalomyelitis Virus-Induced Diseases: An Update.

Int J Mol Sci 2019 Jan 21;20(2). Epub 2019 Jan 21.

Department of Pathology, University of Veterinary Medicine, Bünteweg 17, 30559 Hannover, Germany.

Theiler's murine encephalomyelitis virus (TMEV), a naturally occurring, enteric pathogen of mice is a Cardiovirus of the Picornaviridae family. Low neurovirulent TMEV strains such as BeAn cause a severe demyelinating disease in susceptible mice following intracerebral infection. Furthermore, TMEV infections of mice cause acute polioencephalitis initiating a process of epileptogenesis that results in spontaneous recurrent epileptic seizures in approximately 50% of affected mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20020448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358740PMC
January 2019
3 Reads

Virus envelope tissue factor promotes infection in mice.

J Thromb Haemost 2019 Jan 19. Epub 2019 Jan 19.

Canadian Blood Services, Center for Innovation, Vancouver, Canada.

Essentials The coagulation initiator, tissue factor (TF), is on the herpes simplex virus 1 (HSV1) surface. HSV1 surface TF was examined in mice as an antiviral target since it enhances infection in vitro. HSV1 surface TF facilitated infection of all organs evaluated and anticoagulants were antiviral. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jth.14389DOI Listing
January 2019
6 Reads

The association of adelmidrol with sodium hyaluronate displays beneficial properties against bladder changes following spinal cord injury in mice.

PLoS One 2019 17;14(1):e0208730. Epub 2019 Jan 17.

University of Messina, Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, Messina, Italy.

The disruption of coordinated control between the brain, spinal cord and peripheral nervous system caused by spinal cord injury (SCI) leads to several secondary pathological conditions, including lower urinary tract dysfunction. In fact, urinary tract dysfunction associated with SCI is urinary dysfunction could be a consequence of a lack of neuroregeneration of supraspinal pathways that control bladder function. The object of the current research was to explore the effects of adelmidrol + sodium hyaluronate, on bladder damage generated after SCI in mice. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208730PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336272PMC
January 2019
1 Read

Retrospective analysis of complications associated with dorsal root ganglion stimulation for pain relief in the FDA MAUDE database.

Reg Anesth Pain Med 2019 Jan;44(1):100-106

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.

Background And Objectives: Dorsal root ganglion stimulation is an emerging therapy in the treatment of chronic pain. Compared with traditional spinal cord stimulation, it allows a discretely targeted stimulation profile and may act via differing mechanisms of action. Despite these advantages, little is known about the complications associated with this new modality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/rapm-2018-000007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363531PMC
January 2019
2 Reads

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.

Authors:
Clotilde Théry Kenneth W Witwer Elena Aikawa Maria Jose Alcaraz Johnathon D Anderson Ramaroson Andriantsitohaina Anna Antoniou Tanina Arab Fabienne Archer Georgia K Atkin-Smith D Craig Ayre Jean-Marie Bach Daniel Bachurski Hossein Baharvand Leonora Balaj Shawn Baldacchino Natalie N Bauer Amy A Baxter Mary Bebawy Carla Beckham Apolonija Bedina Zavec Abderrahim Benmoussa Anna C Berardi Paolo Bergese Ewa Bielska Cherie Blenkiron Sylwia Bobis-Wozowicz Eric Boilard Wilfrid Boireau Antonella Bongiovanni Francesc E Borràs Steffi Bosch Chantal M Boulanger Xandra Breakefield Andrew M Breglio Meadhbh Á Brennan David R Brigstock Alain Brisson Marike Ld Broekman Jacqueline F Bromberg Paulina Bryl-Górecka Shilpa Buch Amy H Buck Dylan Burger Sara Busatto Dominik Buschmann Benedetta Bussolati Edit I Buzás James Bryan Byrd Giovanni Camussi David Rf Carter Sarah Caruso Lawrence W Chamley Yu-Ting Chang Chihchen Chen Shuai Chen Lesley Cheng Andrew R Chin Aled Clayton Stefano P Clerici Alex Cocks Emanuele Cocucci Robert J Coffey Anabela Cordeiro-da-Silva Yvonne Couch Frank Aw Coumans Beth Coyle Rossella Crescitelli Miria Ferreira Criado Crislyn D'Souza-Schorey Saumya Das Amrita Datta Chaudhuri Paola de Candia Eliezer F De Santana Olivier De Wever Hernando A Del Portillo Tanguy Demaret Sarah Deville Andrew Devitt Bert Dhondt Dolores Di Vizio Lothar C Dieterich Vincenza Dolo Ana Paula Dominguez Rubio Massimo Dominici Mauricio R Dourado Tom Ap Driedonks Filipe V Duarte Heather M Duncan Ramon M Eichenberger Karin Ekström Samir El Andaloussi Celine Elie-Caille Uta Erdbrügger Juan M Falcón-Pérez Farah Fatima Jason E Fish Miguel Flores-Bellver András Försönits Annie Frelet-Barrand Fabia Fricke Gregor Fuhrmann Susanne Gabrielsson Ana Gámez-Valero Chris Gardiner Kathrin Gärtner Raphael Gaudin Yong Song Gho Bernd Giebel Caroline Gilbert Mario Gimona Ilaria Giusti Deborah Ci Goberdhan André Görgens Sharon M Gorski David W Greening Julia Christina Gross Alice Gualerzi Gopal N Gupta Dakota Gustafson Aase Handberg Reka A Haraszti Paul Harrison Hargita Hegyesi An Hendrix Andrew F Hill Fred H Hochberg Karl F Hoffmann Beth Holder Harry Holthofer Baharak Hosseinkhani Guoku Hu Yiyao Huang Veronica Huber Stuart Hunt Ahmed Gamal-Eldin Ibrahim Tsuneya Ikezu Jameel M Inal Mustafa Isin Alena Ivanova Hannah K Jackson Soren Jacobsen Steven M Jay Muthuvel Jayachandran Guido Jenster Lanzhou Jiang Suzanne M Johnson Jennifer C Jones Ambrose Jong Tijana Jovanovic-Talisman Stephanie Jung Raghu Kalluri Shin-Ichi Kano Sukhbir Kaur Yumi Kawamura Evan T Keller Delaram Khamari Elena Khomyakova Anastasia Khvorova Peter Kierulf Kwang Pyo Kim Thomas Kislinger Mikael Klingeborn David J Klinke Miroslaw Kornek Maja M Kosanović Árpád Ferenc Kovács Eva-Maria Krämer-Albers Susanne Krasemann Mirja Krause Igor V Kurochkin Gina D Kusuma Sören Kuypers Saara Laitinen Scott M Langevin Lucia R Languino Joanne Lannigan Cecilia Lässer Louise C Laurent Gregory Lavieu Elisa Lázaro-Ibáñez Soazig Le Lay Myung-Shin Lee Yi Xin Fiona Lee Debora S Lemos Metka Lenassi Aleksandra Leszczynska Isaac Ts Li Ke Liao Sten F Libregts Erzsebet Ligeti Rebecca Lim Sai Kiang Lim Aija Linē Karen Linnemannstöns Alicia Llorente Catherine A Lombard Magdalena J Lorenowicz Ákos M Lörincz Jan Lötvall Jason Lovett Michelle C Lowry Xavier Loyer Quan Lu Barbara Lukomska Taral R Lunavat Sybren Ln Maas Harmeet Malhi Antonio Marcilla Jacopo Mariani Javier Mariscal Elena S Martens-Uzunova Lorena Martin-Jaular M Carmen Martinez Vilma Regina Martins Mathilde Mathieu Suresh Mathivanan Marco Maugeri Lynda K McGinnis Mark J McVey David G Meckes Katie L Meehan Inge Mertens Valentina R Minciacchi Andreas Möller Malene Møller Jørgensen Aizea Morales-Kastresana Jess Morhayim François Mullier Maurizio Muraca Luca Musante Veronika Mussack Dillon C Muth Kathryn H Myburgh Tanbir Najrana Muhammad Nawaz Irina Nazarenko Peter Nejsum Christian Neri Tommaso Neri Rienk Nieuwland Leonardo Nimrichter John P Nolan Esther Nm Nolte-'t Hoen Nicole Noren Hooten Lorraine O'Driscoll Tina O'Grady Ana O'Loghlen Takahiro Ochiya Martin Olivier Alberto Ortiz Luis A Ortiz Xabier Osteikoetxea Ole Østergaard Matias Ostrowski Jaesung Park D Michiel Pegtel Hector Peinado Francesca Perut Michael W Pfaffl Donald G Phinney Bartijn Ch Pieters Ryan C Pink David S Pisetsky Elke Pogge von Strandmann Iva Polakovicova Ivan Kh Poon Bonita H Powell Ilaria Prada Lynn Pulliam Peter Quesenberry Annalisa Radeghieri Robert L Raffai Stefania Raimondo Janusz Rak Marcel I Ramirez Graça Raposo Morsi S Rayyan Neta Regev-Rudzki Franz L Ricklefs Paul D Robbins David D Roberts Silvia C Rodrigues Eva Rohde Sophie Rome Kasper Ma Rouschop Aurelia Rughetti Ashley E Russell Paula Saá Susmita Sahoo Edison Salas-Huenuleo Catherine Sánchez Julie A Saugstad Meike J Saul Raymond M Schiffelers Raphael Schneider Tine Hiorth Schøyen Aaron Scott Eriomina Shahaj Shivani Sharma Olga Shatnyeva Faezeh Shekari Ganesh Vilas Shelke Ashok K Shetty Kiyotaka Shiba Pia R-M Siljander Andreia M Silva Agata Skowronek Orman L Snyder Rodrigo Pedro Soares Barbara W Sódar Carolina Soekmadji Javier Sotillo Philip D Stahl Willem Stoorvogel Shannon L Stott Erwin F Strasser Simon Swift Hidetoshi Tahara Muneesh Tewari Kate Timms Swasti Tiwari Rochelle Tixeira Mercedes Tkach Wei Seong Toh Richard Tomasini Ana Claudia Torrecilhas Juan Pablo Tosar Vasilis Toxavidis Lorena Urbanelli Pieter Vader Bas Wm van Balkom Susanne G van der Grein Jan Van Deun Martijn Jc van Herwijnen Kendall Van Keuren-Jensen Guillaume van Niel Martin E van Royen Andre J van Wijnen M Helena Vasconcelos Ivan J Vechetti Tiago D Veit Laura J Vella Émilie Velot Frederik J Verweij Beate Vestad Jose L Viñas Tamás Visnovitz Krisztina V Vukman Jessica Wahlgren Dionysios C Watson Marca Hm Wauben Alissa Weaver Jason P Webber Viktoria Weber Ann M Wehman Daniel J Weiss Joshua A Welsh Sebastian Wendt Asa M Wheelock Zoltán Wiener Leonie Witte Joy Wolfram Angeliki Xagorari Patricia Xander Jing Xu Xiaomei Yan María Yáñez-Mó Hang Yin Yuana Yuana Valentina Zappulli Jana Zarubova Vytautas Žėkas Jian-Ye Zhang Zezhou Zhao Lei Zheng Alexander R Zheutlin Antje M Zickler Pascale Zimmermann Angela M Zivkovic Davide Zocco Ewa K Zuba-Surma

J Extracell Vesicles 2018 23;7(1):1535750. Epub 2018 Nov 23.

Jagiellonian University, Faculty of Biochemistry, Biophysics and Biotechnology, Department of Cell Biology, Kraków, Poland.

The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles ("MISEV") guidelines for the field in 2014. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/20013078.2018.1
Publisher Site
http://dx.doi.org/10.1080/20013078.2018.1535750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322352PMC
November 2018
35 Reads

Neurogenic stress urinary incontinence: is there a place for Adjustable Continence Therapy (ACT™ and ProACT™, Uromedica, Plymouth, MN, USA)? A retrospective multicenter study.

Spinal Cord 2019 Jan 9. Epub 2019 Jan 9.

Department of Neurological Physical Medicine and Rehabilitation, Saint-Jacques Hospital, Nantes University Hospital, Nantes, France.

Study Design: Retrospective cohort study.

Objectives: To assess the effectiveness and complications of treatment for neurogenic stress urinary incontinence (nSUI) by Adjustable Continence Therapy (ACT™ and ProACT™).

Setting: France. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41393-018-0219-3DOI Listing
January 2019
1 Read

Classical homeopathy for the prophylaxis of recurrent urinary tract infections.

J Spinal Cord Med 2019 Jan 9. Epub 2019 Jan 9.

b Dr DY Patil University , Pune , India.

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10790268.2018.1
Publisher Site
http://dx.doi.org/10.1080/10790268.2018.1558022DOI Listing
January 2019
1 Read

Theiler's Virus-Mediated Immunopathology in the CNS and Heart: Roles of Organ-Specific Cytokine and Lymphatic Responses.

Front Immunol 2018 10;9:2870. Epub 2018 Dec 10.

Department of Microbiology, Kindai University Faculty of Medicine, Osaka, Japan.

Theiler's murine encephalomyelitis virus (TMEV) induces different diseases in the central nervous system (CNS) and heart, depending on the mouse strains and time course, with cytokines playing key roles for viral clearance and immune-mediated pathology (immunopathology). In SJL/J mice, TMEV infection causes chronic TMEV-induced demyelinating disease (TMEV-IDD) in the spinal cord about 1 month post-inoculation (p.i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2018.02870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295469PMC
December 2018
9 Reads

The increasing frequency of intravenous drug abuse-associated spinal epidural abscesses: a case series.

Neurosurg Focus 2019 Jan;46(1):E4

1Department of Neurosurgery, Louisiana State University Health Sciences Center, New Orleans, Louisiana; and.

OBJECTIVEFew studies have been published specifically examining intravenous drug abuse (IVDA)-associated spinal epidural abscesses (SEAs), an unfortunate sequela of the opioid crisis in the United States. Here, the authors examined a series of patients with IVDA-associated SEAs in order to shed light on this challenging disease entity.METHODSThis study is a retrospective chart review of patients presenting with IVDA-associated SEAs at the authors' institution from 2013 to 2018, spanning the statewide implementation of opioid-prescribing restrictions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3171/2018.10.FOCUS18449DOI Listing
January 2019
2 Reads

Parasitic infections of the spine: case series and review of the literature.

Neurosurg Focus 2019 Jan;46(1):E12

OBJECTIVEAlthough parasitic infections are endemic to parts of the developing world and are more common in areas with developing economies and poor sanitary conditions, rare cases may occur in developed regions of the world.METHODSArticles eligible for the authors' literature review were initially searched using PubMed with the phrases "parasitic infections" and "spine." After the authors developed a list of parasites associated with spinal cord infections from the initial search, they expanded it to include individual diagnoses, using search terms including "neurocysticercosis," "schistosomiasis," "echinococcosis," and "toxoplasmosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3171/2018.10.FOCUS18472DOI Listing
January 2019
2 Reads

Microscopic Keyhole Technique for Surgical Removal of Thoracic Spinal Meningiomas.

World Neurosurg 2019 Jan 3. Epub 2019 Jan 3.

Division of Spine Surgery and Electrophysiological Center, Department of Orthopedics, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, Fujian, China.

Objective: The aim of this study was to evaluate the safety and efficacy of the microscopic minimally invasive keyhole technique for surgical resection of thoracic spinal meningiomas.

Methods: Seventeen consecutive patients with thoracic spinal meningiomas were included in the series from May 2015 to August 2017. All patients were treated using a microscopic keyhole technique through a tubular retractor system. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S18788750183292
Publisher Site
http://dx.doi.org/10.1016/j.wneu.2018.12.099DOI Listing
January 2019
7 Reads

The effect of appropriate bladder management on urinary tract infection rate in patients with a new spinal cord injury: a prospective observational study.

World J Urol 2019 Jan 2. Epub 2019 Jan 2.

Victorian Spinal Cord Service, Austin Health, Heidelberg, Vic, Australia.

Purpose: This study aimed to determine the rate of urinary tract infection (UTI) in patients with a new spinal cord injury (SCI) and identify which bladder management technique is associated with the lowest rate of UTI.

Methods: Adults admitted to the Victorian Spinal Cord Service with a new SCI from 2012 to 2014 were enrolled. Data collected included patient characteristics, SCI level, bladder management and diagnosis of UTI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00345-018-02620-7DOI Listing
January 2019
1 Read

Differential Expression of Genes Related to Innate Immune Responses in Ex Vivo Spinal Cord and Cerebellar Slice Cultures Infected with West Nile Virus.

Brain Sci 2018 Dec 24;9(1). Epub 2018 Dec 24.

Departments of Neurology, University of Mississippi Medical Center, Jackson, MS 39216, USA.

West Nile virus (WNV) infection results in a spectrum of neurological symptoms, ranging from a benign fever to severe WNV neuroinvasive disease with high mortality. Many who recover from WNV neuroinvasive infection present with long-term deficits, including weakness, fatigue, and cognitive problems. While neurons are a main target of WNV, other cell types, especially astrocytes, play an important role in promoting WNV-mediated central nervous system (CNS) damage. Read More

View Article

Download full-text PDF

Source
http://www.mdpi.com/2076-3425/9/1/1
Publisher Site
http://dx.doi.org/10.3390/brainsci9010001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356470PMC
December 2018
8 Reads

Low sulfated heparins target multiple proteins for central nervous system repair.

Glia 2019 Apr 26;67(4):668-687. Epub 2018 Dec 26.

Institute of Infection, Immunity, and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

The lack of endogenous repair following spinal cord injury (SCI) accounts for the frequent permanent deficits for which effective treatments are absent. Previously, we demonstrated that low sulfated modified heparin mimetics (LS-mHeps) attenuate astrocytosis, suggesting they may represent a novel therapeutic approach. mHeps are glycomolecules with structural similarities to resident heparan sulfates (HS), which modulate cell signaling by both sequestering ligands, and acting as cofactors in the formation of ligand-receptor complexes. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/glia.23562
Publisher Site
http://dx.doi.org/10.1002/glia.23562DOI Listing
April 2019
4 Reads

Risk of Transverse Myelitis Following Dengue Infection: A Systematic Review of the Literature.

Pharmacy (Basel) 2018 Dec 23;7(1). Epub 2018 Dec 23.

Paediatric Infectious Diseases Research Group, Institute for Infection and Immunity, St. George's, University of London, London SW17 0RE, UK.

Introduction: Dengue virus (DENV) is one of the most common arbovirus diseases, with a wide spectrum of presentation. Spinal cord involvement in dengue infection (DF) is rare. However, the risk of transverse myelitis (TM) following Dengue has not been systematically assessed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/pharmacy7010003DOI Listing
December 2018
8 Reads

Joint-preserving treatment for type 3 sequelae following fracture of the proximal humerus with small head fragments.

J Orthop Sci 2018 Dec 20. Epub 2018 Dec 20.

AUVA Trauma Center Salzburg, Academic Teaching Hospital of the Paracelsus Medical University, Salzburg, Austria. Electronic address:

Background: Although nonunions of the proximal humerus are rare, they cause significant disability to patients. Surgical reconstruction is challenging, especially with small and excavated head fragments. A promising surgical option is open reduction and stabilization using the Humerusblock device along with tension wires. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09492658183036
Publisher Site
http://dx.doi.org/10.1016/j.jos.2018.11.020DOI Listing
December 2018
4 Reads

Thoracic Epidural Abscesses: A Systematic Review.

Global Spine J 2018 Dec 13;8(4 Suppl):68S-84S. Epub 2018 Dec 13.

Cleveland Clinic, Cleveland, OH, USA.

Study Design: Systematic review.

Objectives: Past research has demonstrated increased speed and severity of progression for spinal epidural abscesses (SEAs) of the thoracic level, specifically, when compared with SEAs of other spinal cord levels. Untreated, this infection can result in permanent neurological sequelae with eventual progression to death if inadequately managed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2192568218763324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295817PMC
December 2018
1 Read

Froin's syndrome associated with spinal tuberculosis.

BMJ Case Rep 2018 Dec 19;11(1). Epub 2018 Dec 19.

Oxford University Clinical Research Unit, Patan Hospital, Kathmandu, Nepal.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-228367DOI Listing
December 2018
2 Reads

Surgery for traumatic fractures of the upper thoracic spine (T1-T6).

Surg Neurol Int 2018 19;9:231. Epub 2018 Nov 19.

Department of Neurosurgery, University of Kansas Medical Center, Kansas City, KS, USA.

Background: The management of traumatic upper thoracic spine fractures (T1-T6) is complex due to the unique biomechanical/physiological characteristics of these levels and the nature of the injuries. They are commonly associated with multiple other traumatic injuries and severe spinal cord injuries. We describe the safety and efficacy of surgery for achieving stability and maintaining reduction of upper thoracic T1-T6 spine fractures. Read More

View Article

Download full-text PDF

Source
http://surgicalneurologyint.com/surgicalint-articles/surgery
Publisher Site
http://dx.doi.org/10.4103/sni.sni_273_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262946PMC
November 2018
15 Reads

Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy: A Review of the Literature.

Front Immunol 2018 5;9:2802. Epub 2018 Dec 5.

Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is an autoimmune disease of the nervous system first defined in 2016. GFAP autoantibody, especially IgG that binds to GFAPα, has been reported in the cerebrospinal fluid (CSF) and serum of patients with GFAP astrocytopathy. The positive predictive value of GFAP antibody in the CSF is higher than in the serum. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2018.02802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290896PMC
December 2018