374,587 results match your criteria Spinal Cord Infections


Ventilation/perfusion SPECT/CT in patients with severe and rigid scoliosis: An evaluation by relationship to spinal deformity and lung function.

Clin Neurol Neurosurg 2018 Dec 6;176:97-102. Epub 2018 Dec 6.

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 37 Guoxue Rd, Chengdu, 610041, China. Electronic address:

Objective: Structural changes of the spine and chest wall associated with SRS result in poor cardiopulmonary function. Comprehensive assessment of pulmonary function is extremely important for patients with SRS before a correction operation. We explore the changes of distribution of lung ventilation and perfusion function in patients with SRS using SPECT/CT and describe the relation between these changes with Cobb angle and FVC%. Read More

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December 2018

Idiopathic toe walking-A follow-up survey of gait analysis assessment.

Gait Posture 2018 Dec 6;68:300-304. Epub 2018 Dec 6.

School of Physiotherapy, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland.

Background: Toe-walking is a normal variant in children up to 3 years of age but beyond this a diagnosis of idiopathic toe-walking (ITW) must be considered. ITW is an umbrella term that covers all cases of toe-walking without any diagnosed underlying medical condition and before assigning these diagnosis potential differential diagnoses such as cerebral palsy, peripheral neuropathy, spinal dysraphism and myopathy must be ruled out. Gait laboratory assessment (GLA) is thought to be useful in the evaluation of ITW, and kinematic, kinetic and electromyography features associated with ITW have been described. Read More

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December 2018

Analgesic and anti-edemic properties of etifoxine in models of inflammatory sensitization.

Eur J Pharmacol 2018 Dec 12. Epub 2018 Dec 12.

Centre National de la Recherche Scientifique and University of Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, 67000 Strasbourg, France. Electronic address:

Inflammatory processes are critical promoting factors of chronic pain states, mostly by inducing peripheral and central sensitization of the nociceptive system. These processes are associated with a massive increase in glutamatergic transmission, sometimes facilitated by spinal disinhibition. In this study, we used etifoxine, a non-benzodiazepine anxiolytic known to amplify inhibition mediated by gamma-aminobutyric acid type A (GABA) receptors in pain processing regions, either directly (through allosteric modulation) or indirectly (through the synthesis of endogenous neurosteroids). Read More

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December 2018

Existence and features of the myodural bridge in Gallus domesticus: indication of its important physiological function.

Anat Sci Int 2018 Dec 14. Epub 2018 Dec 14.

Department of Anatomy, College of Basic Medicine, Dalian Medical University, Dalian, China.

The myodural bridge (MDB) is a dense connective tissue that connects muscles with the cervical spinal dura mater via the posterior atlanto-occipital and atlato-axial interspaces. To date, the physiological function of the MDB has not been fully elucidated. Recent studies have identified the presence of the MDB in mammals, but very little information is available on the existence of the MDB in avifauna. Read More

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December 2018

Using chloroprocaine for spinal anaesthesia in outpatient knee-arthroscopy results in earlier discharge and improved operating room efficiency compared to mepivacaine and prilocaine.

Knee Surg Sports Traumatol Arthrosc 2018 Dec 14. Epub 2018 Dec 14.

Department of Anaesthesiology, Intensive Care and Pain Medicine, BG Klinikum Unfallkrankenhaus Berlin gGmbH, Warener Str. 7, 12683, Berlin, Germany.

Purpose: Knee arthroscopies are regularly carried out in an outpatient setting. The purpose of this retrospective analysis was to investigate the impact of different local anaesthetics for spinal anaesthesia on operating room efficiency (perioperative process times) and postoperative recovery. This study aims to determine the optimal LA for SPA in patients undergoing knee arthroscopy at a day-surgery centre. Read More

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December 2018

[Lumbar fusion-Indications and techniques].

Orthopade 2018 Dec 14. Epub 2018 Dec 14.

Wirbelsäulenzentrum, Schön Klinik München Harlaching, Harlachinger Str. 51, 81547, München, Deutschland.

Background: Lumbar spinal fusion is an established surgical technique in spine surgery. The goal of spinal fusion is a biomechanically lasting interbody union, which can be accomplished through different surgical approaches, implants and grafts.

Techniques: The mainly surgical techniques used are: posterior lumbar fusion (PLF), posterior interbody lumbar fusion (PLIF), transforaminal lumbar interbody fusion (TLIF), anterior lumbar interbody fusion (ALIF), oblique lumbar interbody fusion (OLIF) and extreme lateral interbody fusion (XLIF). Read More

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December 2018

Spasticity and preservation of skeletal muscle mass in people with spinal cord injury.

Spinal Cord 2018 Dec 14. Epub 2018 Dec 14.

Department of Rehabilitation Medicine, College of Medicine, Seoul National University, Seoul, Korea.

Study Design: Cross-sectional OBJECTIVE: To investigate the association between skeletal muscle mass and spasticity in people with spinal cord injury (SCI).

Setting: Tertiary level hospital in Seoul, Korea METHODS: Spasticity was evaluated in 69 participants with SCI using the spasticity sum score (SSS), Penn Spasm Frequency Scale (PSFS), and Spinal Cord Assessment Tool for Spastic Reflexes (SCATS). Skeletal muscle mass was measured using a dual-energy X-ray absorptiometry scanner, and skeletal muscle index was calculated by dividing skeletal muscle mass by height squared. Read More

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December 2018

Global mapping for the epidemiology of paediatric spinal cord damage: towards a living data repository.

Spinal Cord 2018 Dec 14. Epub 2018 Dec 14.

Kids Rehab, The Children's Hospital at Westmead, Westmead, NSW, Australia.

Study Design: Literature review.

Objectives: Globally map key paediatric spinal cord damage epidemiological measures and provide a framework for an ongoing repository of data.

Setting: Worldwide, initiative of ISCoS Prevention Committee. Read More

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December 2018

Validation of the short version of the Van Lieshout Test in an Italian population with cervical spinal cord injuries: a cross-sectional study.

Spinal Cord 2018 Dec 14. Epub 2018 Dec 14.

Department of Public Health and Infection Disease, Sapienza University of Rome, Rome, Italy.

Study Design: Psychometric study.

Objective: To validate the Italian version of the Van Lieshout Test Short Version (VLT-SV) with a spinal cord injury population.

Setting: Three Italian spinal units. Read More

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December 2018

Non-traumatic spinal cord injury in Norway 2012-2016: analysis from a national registry and comparison with traumatic spinal cord injury.

Spinal Cord 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurology, Haukeland University Hospital, Bergen, Norway.

Study Design: Registry-based cross-sectional study.

Objectives: To describe and analyze epidemiological and demographic characteristics of non-traumatic spinal cord injury (NTSCI) and to compare persons with NTSCI and traumatic spinal cord injury (TSCI).

Setting: A total of 225 non-traumatic and 349 traumatic SCI patients were admitted for primary rehabilitation at one of the three specialized SCI departments in Norway (located in Bergen, Trondheim, and Oslo) from 2012 to 2016. Read More

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December 2018

Miniscule differences between sex chromosomes in the giant genome of a salamander.

Sci Rep 2018 Dec 14;8(1):17882. Epub 2018 Dec 14.

Department of Biology, University of Kentucky, Lexington, KY, USA.

In the Mexican axolotl (Ambystoma mexicanum), sex is determined by a single Mendelian factor, yet its sex chromosomes do not exhibit morphological differentiation typical of many vertebrate taxa that possess a single sex-determining locus. As sex chromosomes are theorized to differentiate rapidly, species with undifferentiated sex chromosomes provide the opportunity to reconstruct early events in sex chromosome evolution. Whole genome sequencing of 48 salamanders, targeted chromosome sequencing and in situ hybridization were used to identify the homomorphic sex chromosome that carries an A. Read More

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December 2018

Understanding cauda equina syndrome: protocol for a UK multicentre prospective observational cohort study.

BMJ Open 2018 Dec 14;8(12):e025230. Epub 2018 Dec 14.

Department for Clinical Neurosciences, Western General Hospital, Edinburgh, UK.

Introduction: Cauda equina syndrome (CES) is a potentially devastating condition caused by compression of the cauda equina nerve roots. This can result in bowel, bladder and sexual dysfunction plus lower limb weakness, numbness and pain. CES occurs infrequently, but has serious potential morbidity and medicolegal consequences. Read More

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December 2018

Ten-year trends in traumatic brain injury: a retrospective cohort study of California emergency department and hospital revisits and readmissions.

BMJ Open 2018 Dec 14;8(12):e022297. Epub 2018 Dec 14.

Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.

Objective: To describe visits and visit rates of adults presenting to emergency departments (EDs) with a diagnosis of traumatic brain injury (TBI). TBI is a major cause of death and disability in the USA; yet, current literature is limited because few studies examine longer-term ED revisits and hospital readmission patterns of TBI patients across a broad spectrum of injury severity, which can help inform potential unmet healthcare needs.

Design: We performed a retrospective cohort study. Read More

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December 2018

A Notch-regulated proliferative stem cell zone in the developing spinal cord is an ancestral vertebrate trait.

Development 2018 Dec 14. Epub 2018 Dec 14.

Department of Zoology, University of Oxford, 11a Mansfield Road, Oxford, OX1 3SZ, UK

Vertebrates have evolved the most sophisticated nervous systems we know. These differ from the nervous systems of invertebrates in several ways, including the evolution of new cell types, and the emergence and elaboration of patterning mechanisms to organise cells in time and space. Vertebrates also generally have many more cells in their central nervous systems than invertebrates, and an increase in neural cell number may have contributed to the sophisticated anatomy of the brain and spinal cord. Read More

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December 2018

HDAC inhibitor valproic acid protects heart function through Foxm1 pathway after acute myocardial infarction.

EBioMedicine 2018 Dec 11. Epub 2018 Dec 11.

Department of Cardiac Surgery, Cardiovascular Center, The University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

Background: Epigenetic histone acetylation is a major event controlling cell functions, such as metabolism, differentiation and repair. Here, we aim to determine whether Valproic acid (VPA), a FDA approved inhibitor of histone deacetylation for bipolar disease, could protect heart against myocardial infarction (MI) injury and elucidate key molecular pathways.

Methods: VPA was administrated to MI rats at different time points, onset and after MI injury. Read More

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December 2018

The novel small-molecule antagonist of PAC1 receptor attenuates formalin-induced inflammatory pain behaviors in mice.

J Pharmacol Sci 2018 Dec 1. Epub 2018 Dec 1.

Department of Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.

We recently developed PA-8, a novel small-molecule antagonist of PACAP type 1 (PAC1) receptor. In the present study, we examined whether PA-8 was effective against formalin-induced inflammatory pain in mice. Both intrathecal and oral administration of PA-8 resulted in the dose-dependent attenuation of the second phase of formalin-induced nociceptive responses. Read More

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December 2018

Cold evoked potentials: Acquisition from cervical dermatomes.

Neurophysiol Clin 2018 Dec 11. Epub 2018 Dec 11.

Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Forchstrasse 340, 8008 Zurich, Switzerland. Electronic address:

Introduction: Cold evoked potentials (CEPs) represent a novel technique to assess the integrity of cold-specific pathways within the somatosensory system. So far an objective assessment of these pathways has not been implemented into the clinical routine. Specifically, CEPs may help to elucidate the pathophysiological underpinnings of altered cold processing in neurological diseases. Read More

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December 2018
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Modified external fixator in pediatric multilevel noncontiguous cervical spinal fracture dislocation: A case report.

J Orthop Sci 2018 Dec 11. Epub 2018 Dec 11.

Orthopedics and Trauma Surgery Department of Grand-Yoff General Hospital, Cheikh Anta Diop University of Dakar, Senegal.

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December 2018

Inhibition of TREM1 reduces inflammation and oxidative stress after spinal cord injury (SCI) associated with HO-1 expressions.

Biomed Pharmacother 2019 Jan 26;109:2014-2021. Epub 2018 Nov 26.

Orthopedics Department, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Pudong, Shanghai, 201399, China. Electronic address:

Spinal cord injury (SCI) is a devastating event, leading to the progression of chronic neuropathic pain syndrome. Triggering receptor expressed on myeloid cells 1 (TREM1) is an innate immune receptor expressed on neutrophils and monocytes/macrophages. TREM1 enhances inflammatory response in various models of diseases, but its significance in SCI remains unclear. Read More

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January 2019

Ankylosing spondylitis and mesenchymal stromal/stem cell therapy: a new therapeutic approach.

Biomed Pharmacother 2019 Jan 6;109:1196-1205. Epub 2018 Nov 6.

Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Ankylosing spondylitis (AS) is an inflammatory rheumatoid disease categorized within spondyloarthropathies (SpA) and manifested by chronic spinal arthritis. Several innate and adaptive immune cells and secreted-mediators have been indicated to play a role in AS pathogenesis. Considering the limitations of current therapeutic approaches (NSAIDs, glucocorticoids, DMARDs and biologic drugs), finding new treatments with fewer side effects and high therapeutic potentials are required in AS. Read More

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January 2019

Partial Costotransversectomy and Corpectomy for Thoracic Spinal Metastatic Disease: Operative Technique and Nuances: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurologic Surgery, Mayo Clinic Florida, Jacksonville, Florida.

We describe the operative approach and management for thoracic metastatic disease in a 78-yr-old man with worsening mechanical lower back and left-sided thoracic radicular pain. Imaging of the thoracic spine revealed an osteolytic T11 mass with destruction of the left T11 pedicle and transverse process. Biopsy confirmed spinal metastasis from the liver. Read More

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December 2018

Just the Tip: Resection of a Narcotic Catheter-Tip Granuloma: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurosurgery, University of Miami, Jackson Memorial Hospital, Miami, Florida.

The catheter tip "granuloma" is a rare inflammatory mass that forms in about 3% of patients with an intradural catheter, most commonly from a morphine pump. It has also been seen with other narcotic pumps, narcotic-non-narcotic combinations, and baclofen pumps. Mass formation is associated with increased opioid dose and concentration. Read More

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December 2018

Multi-segment spine kinematics: Relationship with dance training and low back pain.

Gait Posture 2018 Dec 4;68:274-279. Epub 2018 Dec 4.

Centre for Sport Research, School of Exercise and Nutrition Sciences, Deakin University, 221 Burwood Highway, Burwood, VIC 3125, Australia; Sport Performance Research Institute New Zealand, Auckland University of Technology, 17 Antares Place, Rosedale, Auckland 0632, New Zealand. Electronic address:

Background: Spine posture, range of motion (ROM) and movement asymmetry can contribute to low back pain (LBP). These variables may have greater impact in populations required to perform repetitive spine movements, such as dancers; however, there is limited evidence to support this.

Research Question: What is the influence of dance and LBP on spinal kinematics?

Methods: In this cross-sectional study, multi-segment spinal kinematics were examined in 60 female participants, including dancers (n = 21) and non-dancers (n = 39) with LBP (n = 33) and without LBP (n = 27). Read More

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December 2018
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Syngeneic, in contrast to allogeneic, mesenchymal stem cells have superior therapeutic potential following spinal cord injury.

J Neuroimmunol 2018 Nov 16;328:5-19. Epub 2018 Nov 16.

Department of Neurology and Neurosurgery, Karolinska University Hospital, BioClinicum, Solnavägen 30, Solna, Stockholm 17176, Sweden; Center for Molecular Medicine, Karolinska Institutet, Solna 17176, Stockholm, Sweden; Department of Clinical Neuroscience, Karolinska Institutet, Solna 17176, Stockholm, Sweden. Electronic address:

We evaluated the importance of histocompatibility of transplanted MSCs in terms of therapeutic potential. Mouse syngeneic MSCs or allogeneic MSCs were transplanted following SCI in mouse. In this study we found that syngeneic, but not allogeneic, MSCs alternatively activated macrophages resulting in a down-regulation of pro-inflammation. Read More

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November 2018
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Lysophosphatidic acid receptor type 2 activation contributes to secondary damage after spinal cord injury in mice.

Brain Behav Immun 2018 Dec 11. Epub 2018 Dec 11.

Departament de Biologia Cel·lular, Fisiologia i Immunologia, Institut de Neurociències, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Universitat Autònoma de Barcelona, Bellaterra, Catalonia, 08193, Spain. Electronic address:

Lysophosphatidic acid (LPA) is an extracellular lipid mediator involved in many physiological functions by signaling through six known G-protein-coupled receptors (LPA-LPA). In the central nervous system (CNS), LPA mediates a wide range of effects, including neural progenitor cell physiology, astrocyte and microglia activation, neuronal cell death, axonal retraction, and contributions to pain, schizophrenia and hydrocephalus. We recently reported that LPA-LPA signaling mediates functional deficits and myelin loss after spinal cord injury (SCI). Read More

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December 2018

Osteocytes reflect a pro-inflammatory state following spinal cord injury in a rodent model.

Bone 2018 Dec 11. Epub 2018 Dec 11.

Department of Neuroscience and Experimental Therapeutics, Texas A&M Health Science Center, Bryan, TX, United States of America.

Profound bone loss occurs following spinal cord injury (SCI) resulting in a high incidence of fractures. While likely caused in part by loss of weight-bearing, there is greater bone loss following SCI when compared to that observed in other disuse animal models. Patients with SCI have a protracted inflammatory response, with elevated circulating levels of pro-inflammatory markers. Read More

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December 2018

Somatosensory Evoked Potential Changes and Decompression Timing for Spinal Cord Function Recovery and Evoked Potentials in Rats with Spinal Cord Injury.

Brain Res Bull 2018 Dec 11. Epub 2018 Dec 11.

Department of Anesthesiology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, China. Electronic address:

Objective: The study aimed to evaluate changes of somatosensory evoked potentials and the effects of decompression timing on spinal cord recovery and evoked potentials by measuring the somatosensory evoked potentials of rats with spinal cord injury at different time points.

Methods: A total of 70 SD rats were divided into the control group (group A) and the experimental group. The experimental groups included group B, C and D according to the severity of spinal cord injury. Read More

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December 2018

Musculoskeletal injuries and absenteeism among healthcare professionals-ICD-10 characterization.

PLoS One 2018 14;13(12):e0207837. Epub 2018 Dec 14.

Department of Occupational Health, Centro Hospitalar Universitário São João, Porto, Portugal.

Introduction: Healthcare workers account for 10% of the EU's total workforce, with a significant proportion of those employed in hospitals. Musculoskeletal injuries are the predominant group of injuries in healthcare professionals due to the physical demands of their work, such as the mobilization and positioning of the dependent patients. The management of this type of problem should take into account direct and indirect costs, such as periods of incapacity for work due to illness, hiring and training of new employees during periods of absence, reduced levels of productivity and the effects on production and quality of work. Read More

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December 2018
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Comparative study between Plate-Graff, Plate-Cage and peek cage in cervical spine fusion.

Acta Ortop Mex 2018 Jul-Aug;32(4):203-208

Spine Surgery Service. National Institute of Rehabilitation Luis Guillermo Ibarra Ibarra. Mexico City. Mexico.

Objective: To compare results of Plate-Graff, Plate-Cage and PEEK cage in patients with cervical stenosis.

Material And Methods: Prospective, with before and after intervention and comparative study. From January 2005 to October 2011 we included 37 patients (male: 48. Read More

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December 2018

Open Microsurgical Dorsal Root Ganglion Lead Placement.

Neuromodulation 2018 Dec 14. Epub 2018 Dec 14.

Department of Stereotactic and Functional Neurosurgery, Heinrich-Heine University, Düsseldorf, Germany.

Introduction: Dorsal root ganglion stimulation (DRG) is a new but well-established neuromodulation technique allowing new indications and superiority to pre-existing stimulation techniques such as spinal cord stimulation in selected pain etiologies. Previous surgical procedures in the implantation area pose a challenge for the percutaneous technique and are therefore considered contraindications for DRG stimulation surgery. We describe the successful open DRG electrode placement in two patients with previous surgeries suffering from severe radiculopathy due to foraminal stenosis. Read More

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December 2018

Acid Sensing Ion Channel 2: a new potential player in the pathophysiology of multiple sclerosis.

Eur J Neurosci 2018 Dec 14. Epub 2018 Dec 14.

Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.

Acid Sensing Ion Channel (ASICs) are proton-gated channels involved in multiple biological functions such as: pain modulation, mechanosensation, neurotransmission and neurodegeneration. Earlier, we described the genetic association, within the Nuoro population, between multiple sclerosis (MS) and rs28936, located in ASIC2 3'UTR. Here we investigated the potential involvement of ASIC2 in MS inflammatory process. Read More

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December 2018
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Injecting RNA interference lentiviruses targeting the muscarinic 3 receptor gene into the bladder wall inhibits neurogenic detrusor overactivity in rats with spinal cord injury.

Neurourol Urodyn 2018 Dec 14. Epub 2018 Dec 14.

Department of Urology, Xuanwu Hospital Capital Medical University, Xuanwu District, Beijing, China.

Aims: To investigate the effects of injecting RNA interference (RNAi) lentiviruses targeting the muscarinic 3 (M ) receptor gene into the bladder wall on bladder activity in rats with spinal cord injury (SCI).

Methods: Four M RNAi lentiviruses were constructed and used to infect primary cultured bladder smooth muscle cells (BSMCs). Western blotting and quantitative reverse transcription polymerase chain reaction (qRT-PCR) were performed to determine the optimal RNAi lentivirus with the highest interference efficiency. Read More

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December 2018

Synapse preservation and decreased glial reactions following ventral root crush (VRC) and treatment with 4-hydroxy-tempo (TEMPOL).

J Neurosci Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil.

Astrogliosis and microglial reactions are correlated with the formation of scar tissue and synapse loss. 4-hydroxy-tempo (TEMPOL) is a reactive oxygen species scavenger with proven neuroprotective efficacy in experimental models of traumatic injury and cerebral ischemia. TEMPOL has not, however, been applied following ventral root lesions, which are particularly correlated with the degeneration of spinal motoneurons following brachial plexus injuries. Read More

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December 2018
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Cervical Spinal Cord Stimulation for the Vegetative State: A Preliminary Result of 12 Cases.

Neuromodulation 2018 Dec 13. Epub 2018 Dec 13.

Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, China.

Objectives: Data on the treatment of the vegetative state (VS) with cervical spinal cord stimulation (cSCS) are limited and prognostic factors are inconclusive. In this study, we present our experience of treating 12 VS patients with cSCS and discuss the prognostic factors.

Methods: Twelve VS patients were enrolled. Read More

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December 2018

To sit or not to sit? A systematic review and meta-analysis of seated exercise for older adults.

Australas J Ageing 2018 Dec 13. Epub 2018 Dec 13.

Eastern Health - Allied Health Clinical Research Office, Melbourne, Victoria, Australia.

Objective: To determine the effect of seated exercise on impairment, activity and participation levels of older adults living with a health condition or impairment.

Methods: A systematic search of health databases combined concepts of seated exercise and controlled trials. Selected trials were appraised for quality and results synthesised by calculating standardised mean differences (SMD) and conducting meta-analyses where appropriate. Read More

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December 2018

PREDICTION ALGORITHM OF THE CAT SPINAL SEGMENTS LENGTHS AND POSITIONS IN RELATION TO THE VERTEBRAE.

Anat Rec (Hoboken) 2018 Dec 12. Epub 2018 Dec 12.

Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, Saint-Petersburg, 199034, Russia.

Detailed knowledge of the topographic organization and precise access to the spinal cord segments is crucial for the neurosurgical manipulations as well as in vivo neurophysiological investigations of the spinal networks involved in sensorimotor and visceral functions. Because of high individual variability, accurate identification of particular portion of the lumbosacral enlargement is normally possible only during postmortem dissection. Yet, it is often necessary to determine the precise location of spinal segments prior to in vivo investigation, targeting spinal cord manipulations, neurointerface implantations, and neuronal activity recordings. Read More

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December 2018
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Use of electromyographic signals for characterization of voluntary coughing in humans with and without spinal cord injury-A systematic review.

Physiother Res Int 2018 Dec 13:e1761. Epub 2018 Dec 13.

Graduate Program on Biomedical Engineering, University of Brasília, Brasília, Brazil.

Introduction: Individuals with spinal cord injury (SCI) frequently have an ineffective cough ability due to dysfunctions in expiratory muscles. In such cases, several articles have reported the occurrence of residual muscular activity in muscles that are accessory to coughing. The knowledge about this activity may be useful for building cough assistance devices. Read More

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December 2018

Health outcomes in spinal muscular atrophy type 1 following AVXS-101 gene replacement therapy.

Pediatr Pulmonol 2018 Dec 12. Epub 2018 Dec 12.

Department of Pediatrics, Ohio State University, Columbus, Ohio.

Background: Spinal Muscular Atrophy type 1 (SMA1) is a rare genetic neuromuscular disease where 75% of SMA1 patients die/require permanent-ventilation by 13.6 months. This study assessed the health outcomes of SMA1 infants treated with AVXS-101 gene replacement therapy. Read More

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December 2018
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Astrocyte progenitor transplantation promotes regeneration of bulbospinal respiratory axons, recovery of diaphragm function, and a reduced macrophage response following cervical spinal cord injury.

Glia 2018 Dec 11. Epub 2018 Dec 11.

Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania.

Stem/progenitor cell transplantation delivery of astrocytes is a potentially powerful strategy for spinal cord injury (SCI). Axon extension into SCI lesions that occur spontaneously or in response to experimental manipulations is often observed along endogenous astrocyte "bridges," suggesting that augmenting this response via astrocyte lineage transplantation can enhance axon regrowth. Given the importance of respiratory dysfunction post-SCI, we transplanted glial-restricted precursors (GRPs)-a class of lineage-restricted astrocyte progenitors-into the C2 hemisection model and evaluated effects on diaphragm function and the growth response of descending rostral ventral respiratory group (rVRG) axons that innervate phrenic motor neurons (PhMNs). Read More

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December 2018

MicroRNA-217 relieved neuropathic pain through targeting toll-like receptor 5 expression.

J Cell Biochem 2018 Dec 11. Epub 2018 Dec 11.

Department of Anesthesiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Neuropathic pain is the most common chronic pain that is caused by nerve injury or disease that influences the nervous system. Increasing evidence suggested that microRNAs (miRNAs) play a crucial role in neuropathic pain and neuroinflammation development. However, the functional role of miR-217 in the development of neuropathic pain remains unknown. Read More

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December 2018

The role of polysomnography in decannulation of children with brain and spinal cord injuries.

Pediatr Pulmonol 2018 Dec 11. Epub 2018 Dec 11.

Department of Pediatric Rehabilitation Medicine, Kennedy Krieger Institute, Baltimore, Maryland.

Objective: The objective of this retrospective review was to determine the utility of polysomnography (PSG) in influencing the decision to decannulate pediatric patients with brain and spinal cord injuries in an inpatient rehabilitation hospital setting.

Methods: Between 2010 and 2016, data were collected on pediatric patients with brain and/or spinal cord injuries who had PSG performed with the goal of decannulation. Patients underwent a decannulation protocol involving toleration of continuous tracheostomy capping and bedside tracheoscopy by otolaryngology. Read More

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December 2018

Effects of Multiple Waveforms on Patient Preferences and Clinical Outcomes in Patients Treated With Spinal Cord Stimulation for Leg and/or Back Pain.

Neuromodulation 2018 Dec 11. Epub 2018 Dec 11.

Neurosurgical Clinic Varese Regional Hospital, Varese, Italy.

Objectives: We present the results of a prospective, randomized, crossover, single-blind, study in which each patient is in control of himself. The aim was to evaluate subperception-based (SP-SCS) waveforms in previously implanted spinal cord stimulation (SCS) patients with leg and/or back pain due to failed back surgery syndrome, who experienced only paresthesia-based stimulation (PB-SCS). Patients with PB-SCS experience in SCS was 4. Read More

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December 2018

[Intramedullary spinal cord tumour as differential diagnosis to bilateral muscle weakness].

Ugeskr Laeger 2018 Dec;180(50)

Intramedullary spinal cord tumours (IMSCT) are rare neoplasms, which can potentially lead to severe neurologic deficits. In this case report, an 83-year-old man presented with rapidly progressive bilateral muscle weakness developed within few weeks. MRI revealed a spinal cord tumour at the C7/Th1 vertebral level. Read More

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December 2018

Basal ganglia hemorrhage in a case report following spinal surgery.

BMC Neurol 2018 Dec 14;18(1):204. Epub 2018 Dec 14.

Neurosurgery and Radiology, Neurology Department, University of Minnesota, Minneapolis, MN, USA.

Background: Intracranial hemorrhage is a rare but potentially severe complication of spinal surgery. Most reported post-operative ICH cases consist of cerebellar hemorrhage. There are fewer reported cases of supratentorial ICH following spinal surgery. Read More

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December 2018

Posterior cord syndrome associated with postoperative seroma: The case to perform a complete neurologic exam.

J Spinal Cord Med 2018 Dec 14:1-3. Epub 2018 Dec 14.

b Physical Medicine and Rehabilitation Department , Tufts Medical Center , Boston , Massachusetts , USA.

Context: Posterior cord syndrome (PCS) is the least common incomplete spinal cord injury. Findings of posterior cord syndrome include loss of proprioception and vibration, which are not routinely tested with the American Spinal Cord Injury Association's International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) exam and can easily be missed. Seromas may develop after spinal instrumentation and can cause cord compression. Read More

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December 2018

Accelerometer assessment of physical activity in individuals with paraplegia who do and do not participate in physical exercise.

J Spinal Cord Med 2018 Dec 14:1-7. Epub 2018 Dec 14.

d Departament de Fisioteràpia , Universitat de València , València , Spain.

Objective: Our main goal was to measure physical activity (PA) in people with paraplegia. Secondarily, we aimed to establish the relationship between being engaged in physical exercise (PE) and reaching the recommended moderate-to-vigorous physical activity (MVPA) level. We further analyzed the effect of being engaged in PE on the PA levels. Read More

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December 2018

Cardiac consequence of misdiagnosed vascular complication of spinal lumbar surgery: 6 years of diagnosis delay.

J Cardiol Cases 2016 Jan 16;13(1):6-8. Epub 2015 Sep 16.

University Hospital Ibn Rochd, Cardiology Department, Casablanca, Morocco.

Ilio-caval fistula is a rare complication of lumbar disk surgery that may pose a real diagnostic challenge. We report a case of a 50-year-old woman with overlooked massive right ilio-caval fistula complicating lumbar surgery 6 years previously, and who presented with refractory right heart failure misdiagnosed as chronic pericarditis. The combination of right heart failure and a periumbilical murmur should alert clinicians to investigate with the appropriate imaging tests to confirm the diagnosis. Read More

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January 2016

Systemic Rapamycin Attenuates Morphine-Induced Analgesic Tolerance and Hyperalgesia in Mice.

Neurochem Res 2018 Dec 13. Epub 2018 Dec 13.

Department of Cardiovasology, Tianjin Union Medical Center, 190 Jieyuan St., Hongqiao District, Tianjin, 300121, China.

Previous studies showed that repeated intrathecal morphine injection activated the mammalian target of rapamycin complex 1 (mTORC1) in spinal dorsal horn neurons and that blocking this activation by intrathecal infusion of rapamycin, a specific mTORC1 inhibitor, prevented the initiation of morphine-induced tolerance and hyperalgesia. However, in clinic, rapamycin is usually administrated orally. In this study, we examined whether systemic administration of rapamycin had the effect on morphine-induced tolerance and hyperalgesia in mice. Read More

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December 2018
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Editorial on "Lumbar spinal stenosis: comparison of surgical practice variation and clinical outcome in three national spine registries" by Lønne

J Spine Surg 2018 Sep;4(3):684-686

University Spine Center Zurich, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.

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September 2018

Editorial on: "Superion InterSpinous Spacer Treatment of Moderate Spinal Stenosis: 4-year Results".

J Spine Surg 2018 Sep;4(3):666-667

Centro Chirurgico Toscano, Arezzo, Italy.

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September 2018