2,144 results match your criteria Spinal Cord Infarction


Thrombolysis for atlantoaxial dislocation mimicking acute ischemic stroke: Case report and review.

Am J Emerg Med 2019 Mar 27. Epub 2019 Mar 27.

Stroke Center and Department of Neurology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taiwan; School of Medicine, Tzu Chi University, Hualien, Taiwan. Electronic address:

The frequency of stroke mimics among stroke patients has been reported to be up to 30%, and that in patients who receive thrombolytic therapy ranges between 1% and 16%. Atlantoaxial dislocation with myelopathy mimicking stroke is extremely rare. An 83-year-old man with a history of old cerebellar infarction presented to the emergency department with acute left hemiplegia after a chiropractic manipulation of the neck and back several hours before symptom onset. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajem.2019.03.044DOI Listing
March 2019
2 Reads

Spinal Cord Infarction due to Fibrocartilaginous Embolism: A Report of 3 Cases.

J Stroke Cerebrovasc Dis 2019 Mar 28. Epub 2019 Mar 28.

Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois. Electronic address:

Fibrocartilaginous embolism (FCE) is an uncommon cause of spinal cord infarction often misdiagnosed as transverse myelitis. The mechanism of ischemia is suspected to be due to retrograde embolization of nucleus pulposus material originating from Schmorl's nodes to the spinal vessels following acute disk herniation. We describe the clinical and imaging findings of FCE in 3 healthy young women with history of trivial spinal cord trauma, and recommend that FCE should be considered in the differential diagnosis of acute myelopathy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.03.012DOI Listing
March 2019
1 Read

Spinal cord infarction after tumor removal surgery of the thoracic region - a case report.

Pol Merkur Lekarski 2019 Mar;46(273):142-145

Department of Neuroorthopedics, Mazovian Centre of Rehabilitation STOCER, Konstancin-Jeziorna, Poland.

Spinal cord infarction is very rare condition and usually occurs in the thoracic region of the spine. The etiology is often unknown and patophysiology can be diverse. The stroke may occur while performing a surgical procedure, but it is also found in vascular diseases, for example dissecting aneurysms, vasculitis and vascular malformations. Read More

View Article

Download full-text PDF

Source
March 2019
1 Read

Acute Aortic Dissection in Young Adult Patients: Clinical Characteristics, Management, and Perioperative Outcomes.

J Invest Surg 2019 Mar 25:1-7. Epub 2019 Mar 25.

f Department of Cardiovascular Surgery , Beijing Anzhen Hospital of Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, and Beijing Engineering Research Center of Vascular Prostheses , Beijing , China.

Background: Acute aorta dissection (AD) is a fatal emergency, however, studies addressing the clinical characteristics, management, and outcome of acute AD in young adult patients aged under 45 years in China are very few.

Methods: A retrospective study including 490 patients with acute AD as the final diagnosis was conducted. Patients' demographics, clinical characteristics, medical history, and laboratory and diagnostic imaging findings were retrieved from medical records. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08941939.2018.1489916DOI Listing
March 2019
1 Read

Safety of CT-guided cervical nerve root corticosteroid injections.

J Med Imaging Radiat Oncol 2019 Mar 12. Epub 2019 Mar 12.

Department of Radiology, Alfred Health, Melbourne, Victoria, Australia.

Introduction: Computed tomography-guided cervical nerve root corticosteroid injections are a commonly performed procedure for cervical radiculopathy. There have been major complications such as spinal cord infarction and posterior circulation stroke reported mostly with X-ray fluoroscopic-guided methods, however, there is relatively little data on the safety of newer CT-guided methods. The purpose of this study was to identify any major complications and evaluate the rate of minor complications from CT-guided cervical nerve root corticosteroid injections performed in a tertiary public hospital. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1754-9485.12870DOI Listing
March 2019
2 Reads

A Case of Paradoxical Embolism Causing Anterior Spinal Cord Syndrome and Acute Myocardial Infarction Following the Intradiscal Oxygen-Ozone Therapy.

Front Neurol 2019 22;10:137. Epub 2019 Feb 22.

Hunan Clinical Research Center of Cerebrovascular Disease, Changsha, China.

We report a case of a 66-year-old female who burst into flaccid paralysis of the lower extremities, accompanied by loss of pain and temperature sensation below T4 level, during an oxygen-ozone injection for disc herniation. Half an hour later, she suffered from chest pain. Magnetic resonance imaging (MRI) showed long segment hyperintensity in the thoracic spinal cord from T2 to 10 level on sagittal T2-weighted images (T2WI). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fneur.2019.00137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395432PMC
February 2019

Clinical Potential and Current Progress of Dental Pulp Stem Cells for Various Systemic Diseases in Regenerative Medicine: A Concise Review.

Int J Mol Sci 2019 Mar 6;20(5). Epub 2019 Mar 6.

Department of Oral Implantology, Osaka Dental University, 1-5-17 Otemae Chuo-ku, Osaka 540-0008, Japan.

Dental pulp stem cells (DPSCs) are mesenchymal stem cells (MSCs) that have multipotent differentiation and a self-renewal ability. They have been useful not only for dental diseases, but also for systemic diseases. Extensive studies have suggested that DPSCs are effective for various diseases, such as spinal cord injuries, Parkinson's disease, Alzheimer's disease, cerebral ischemia, myocardial infarction, muscular dystrophy, diabetes, liver diseases, eye diseases, immune diseases, and oral diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20051132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429131PMC

Man With Sudden Paralysis: Insidious Spinal Cord Infarction due to a Non-Ruptured Abdominal Aortic Aneurysm.

J Emerg Med 2019 Apr 26;56(4):413-416. Epub 2019 Feb 26.

Thomas Jefferson University, Philadelphia, Pennsylvania.

Background: Acute infarctions of the spinal cord are rare events characterized by sudden paralysis or sensory deficits below the level of injury. Etiologies include spinal cord trauma, vascular injury, arterial dissection, thromboembolic disease, chronic inflammatory conditions, or mass effect on the spinal cord.

Case Report: A 63-year-old male presented to the emergency department with sudden-onset bilateral leg numbness and weakness. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jemermed.2018.12.038DOI Listing
April 2019
1 Read

Atlanto-occipital dislocation in a patient presenting with out-of-hospital cardiac arrest: a case report and literature review.

J Med Case Rep 2019 Feb 26;13(1):44. Epub 2019 Feb 26.

Division of General Anaesthesiology, Emergency and Intensive Care Medicine, Medical University of Graz, Auenbruggerplatz 5, 8036, Graz, Austria.

Background: Atlanto-occipital dislocation is a rare and severe injury of the upper spine associated with a very poor prognosis.

Case Presentation: We report the case of a 59-year-old European man who suffered from out-of-hospital cardiac arrest following a motor vehicle accident. Cardiopulmonary resuscitation was initiated immediately by bystanders and continued by emergency medical services. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13256-018-1926-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390378PMC
February 2019
2 Reads

Atypical complications of aortic intramural hematoma: Paraplegia resulting from spinal cord infarction.

Int J Cardiol Heart Vasc 2019 Mar 8;22:154-155. Epub 2019 Feb 8.

Division of Cardiology, Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijcha.2019.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369244PMC
March 2019
2 Reads

Interdisciplinary, Intensive, Activity-Based Treatment for Intrauterine Spinal Cord Infarct: A Case Report.

Top Spinal Cord Inj Rehabil 2019 12;25(1):97-103. Epub 2018 Dec 12.

International Center for Spinal Cord Injury, Hugo W. Moser Research Institute at Kennedy Krieger Institute, Baltimore, Maryland.

Intrauterine spinal cord infarcts (IUSCI) with resulting tetraplegia are extremely rare, and there is minimal evidence describing outcomes in this population. This case describes the functional progress of a 3-year-old girl born with IUSCI who participated in activity-based therapies (ABT). Children have developing nervous systems and are particularly suited to benefit from ABT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1310/sci18-00025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368103PMC
April 2019
1 Read

Acute Aortic Occlusion With Spinal Cord Infarction.

Fed Pract 2018 Aug;35(8):32-35

is an Associate Professor and an Associate Residency Director at the University of Arkansas for Medical Sciences (South Central). is a Physician at Baptist Medical Center in North Little Rock and is a Physician at Jefferson Regional Medical Center in Pine Bluff, all in Arkansas. Dr Over is affiliated with the Central Arkansas Veterans Healthcare System Pine Bluff Community-Based Outpatient Clinic.

Abrupt onset bilateral leg pain, sphincter dysfunction, and stigmata of vascular compromise with lower extremity mottling and cool skin should alert providers to the possible presence of acute aortic occlusion in a patient. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263443PMC
August 2018
1 Read

Spinal cord watershed infarction: Novel findings on magnetic resonance imaging.

Clin Imaging 2019 Jan 31;55:71-75. Epub 2019 Jan 31.

Department of Radiology, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32611, USA. Electronic address:

Spinal cord watershed ischemia is a rare phenomenon often associated with cardiac arrest, prolonged hypotension, and atherosclerotic disease. It can manifest as central necrosis with peripheral sparing in the transverse axis, and central lesion with rostral and caudal sparing in the longitudinal axis. Few reports provide detailed imaging findings of spinal cord watershed ischemia lesions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clinimag.2019.01.023DOI Listing
January 2019
1 Read

Imaging of Vascular Disorders of the Spine.

Radiol Clin North Am 2019 Mar 15;57(2):307-318. Epub 2018 Nov 15.

Neuroradiology Division, Department of Radiology and Imaging Sciences, University of Utah Health Sciences Center, 30 North, 1900 East, #1A071, Salt Lake City, UT 84132-2140, USA.

Vascular disorders of the spine are more rare than cerebral vascular entities but can result in significant morbidity. These lesions frequently demonstrate distinguishing characteristics by imaging that are imperative for the radiologist to recognize to properly guide diagnosis and treatment. We review distinguishing imaging characteristics for spinal vascular malformations, spinal emergencies, and spinal vascular masses. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00338389183012
Publisher Site
http://dx.doi.org/10.1016/j.rcl.2018.09.005DOI Listing
March 2019
9 Reads

Spinal cord ischemia following EVAR of a unilateral Iliac artery dissecting aneurysm: a case report.

Ann Vasc Surg 2019 Jan 23. Epub 2019 Jan 23.

Department of Vascular Surgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Purpose: Spinal cord ischemia is a rare complication of endovascular repair of abdominal aortic aneurysm (AAA) that is attributed to the variable anatomy of the artery of Adamkiewicz, embolization of the collateral circulation, or hypoperfusion of cord structures secondary to hypotension.

Case Report: A hypertensive 83-year-old male with chronic obstructive pulmonary disease presented with a 2.3 cm right iliac artery dissecting aneurysm. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.avsg.2018.09.034DOI Listing
January 2019
4 Reads

The phagocytic state of brain myeloid cells after ischemia revealed by superresolution structured illumination microscopy.

J Neuroinflammation 2019 Jan 16;16(1). Epub 2019 Jan 16.

Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, via G. La Masa 19, 20156, Milan, Italy.

Background: Phagocytosis is a key function of myeloid cells and is highly involved in brain ischemic injury. It has been scarcely studied in vivo, thus preventing a deep knowledge of the processes occurring in the ischemic environment. Structured illumination microscopy (SIM) is a superresolution technique which helps study phagocytosis, a process involving the recruitment of vesicles sized below the resolution limits of standard confocal microscopy. Read More

View Article

Download full-text PDF

Source
https://jneuroinflammation.biomedcentral.com/articles/10.118
Publisher Site
http://dx.doi.org/10.1186/s12974-019-1401-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335825PMC
January 2019
10 Reads

Association Between Motor-Evoked Potentials and Spinal Cord Damage Diagnosed With Magnetic Resonance Imaging After Thoracoabdominal and Descending Aortic Aneurysm Repair.

J Cardiothorac Vasc Anesth 2018 Dec 5. Epub 2018 Dec 5.

National Cerebral and Cardiovascular Center, Osaka, Japan.

Objectives: The authors investigated the association between intraoperative motor-evoked potential (MEP) changes and the severity of spinal cord infarction diagnosed with magnetic resonance imaging (MRI) to clarify the discrepancy between them, which was observed in patients with postoperative motor deficits after thoracic and thoracoabdominal aortic surgery.

Design: A multicenter retrospective study.

Setting: Motor-evoked potential <25% of control values was deemed positive for spinal cord ischemia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.jvca.2018.12.004DOI Listing
December 2018
9 Reads

Delayed Paraplegia Triggered by Gastrointestinal Bleeding 8 Months after TEVAR: Persistent Vulnerability of Spinal Cord.

Ann Vasc Dis 2018 Dec;11(4):562-564

Department of Cardiovascular Surgery, KKR Sapporo Medical Center, Sapporo, Hokkaido, Japan.

We report a rare case of delayed paraplegia triggered by gastrointestinal (GI) bleeding 8 months after thoracic endovascular aortic repair (TEVAR). A 78-year-old male underwent TEVAR of a descending thoracic aortic aneurysm without a postoperative neurological deficit and was discharged. Magnetic resonance image showed spinal cord infarction from Th8 to L1, and enhanced computed tomography showed a patent Adamkiewicz artery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3400/avd.cr.18-00090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326056PMC
December 2018
5 Reads

Technical aspects and 30-day outcomes of the prospective early feasibility study of the GORE EXCLUDER Thoracoabdominal Branched Endoprosthesis (TAMBE) to treat pararenal and extent IV thoracoabdominal aortic aneurysms.

J Vasc Surg 2019 Jan 3. Epub 2019 Jan 3.

W. L. Gore & Associates, Inc, TAMBE Team, Flagstaff, Ariz.

Objective: This study reports the technical aspects and 30-day outcomes of the prospective, multicenter early feasibility study designed to evaluate the GORE EXCLUDER Thoracoabdominal Branch Endoprosthesis (TAMBE; W. L. Gore & Associates, Flagstaff, Ariz). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jvs.2018.10.103DOI Listing
January 2019
3 Reads

MiR-34c Ameliorates Neuropathic Pain by Targeting NLRP3 in a Mouse Model of Chronic Constriction Injury.

Neuroscience 2019 02 26;399:125-134. Epub 2018 Dec 26.

Department of Critical Care Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301 Middle Yanchang Road, Jing'an District, Shanghai 200072, China. Electronic address:

MicroRNAs have been reported to be an important pathophysiological factor in neuropathic pain. However, the potential mechanism through which miRNAs function in neuropathic pain remains unclear. The purpose of this study was to explore the potential role of mir-34c in neuropathic pain in a mouse model of chronic constriction injury (CCI). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuroscience.2018.12.030DOI Listing
February 2019
4 Reads

Outcomes and complications after fenestrated-branched endovascular aortic repair.

J Vasc Surg 2018 Dec 24. Epub 2018 Dec 24.

Division of Vascular Surgery, Department of Surgery, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC. Electronic address:

Objective: To report the outcomes of patients enrolled in a physician-sponsored investigational device exemption trial for endovascular treatment of complex thoracoabdominal aortic aneurysms with fenestrated and/or branched devices.

Methods: This study represents a retrospective analysis of a prospectively maintained database of patients enrolled in a physician-sponsored investigational device exemption trial for endovascular treatment of complex thoracoabdominal aneurysms between July 2012 and July 2017. Subjects included high-risk patients for open repair and patients with unsuitable anatomy for either standard endovascular aneurysm repair or Zenith (Cook Medical, Bloomington, Ind) fenestrated device. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jvs.2018.10.052DOI Listing
December 2018
4 Reads

Age and recurrent stroke are related to the severity of white matter hyperintensities in lacunar infarction patients with diabetes.

Clin Interv Aging 2018 7;13:2487-2494. Epub 2018 Dec 7.

Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People's Republic of China,

Background And Purpose: White matter hyperintensities (WMH) is identified as a marker of cerebral small vessel diseases and is a major contributor to cognitive impairment, depression, gait disturbance, and urinary incontinence. However, the risk factors for WMH in patients with type 2 diabetes mellitus (T2DM) has not been well explored. Thus, in this study, we aimed to investigate the relationship between the severity of WMH and vascular risk factors in lacunar infarction patients with T2DM. Read More

View Article

Download full-text PDF

Source
https://www.dovepress.com/age-and-recurrent-stroke-are-relat
Publisher Site
http://dx.doi.org/10.2147/CIA.S184463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290865PMC
February 2019
15 Reads

Cardioprotection via the skin: nociceptor-induced conditioning against cardiac MI in the NIC of time.

Am J Physiol Heart Circ Physiol 2019 Mar 21;316(3):H543-H553. Epub 2018 Dec 21.

Department of Molecular Pharmacology and Therapeutics, Loyola University Chicago, Mawood, Illinois.

Timely reperfusion is still the most effective approach to limit infarct size in humans. Yet, despite advances in care and reduction in door-to-balloon times, nearly 25% of patients develop heart failure postmyocardial infarction, with its attendant morbidity and mortality. We previously showed that cardioprotection results from a skin incision through the umbilicus in a murine model of myocardial infarction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpheart.00094.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415820PMC
March 2019
18 Reads
3.838 Impact Factor

Study on the incidence and risk factor of silent cerebrovascular disease in young adults with first-ever stroke.

Medicine (Baltimore) 2018 Nov;97(48):e13311

Department of Neurology, Beijing Chaoyang Hospital Affiliated to Capital Medical University.

Silent cerebrovascular diseases, including silent brain infarcts (SBI), white matter hyperintensity (WMH), and cerebral microbleed, are closely correlated with stroke progression. The purpose of this study was to investigate the prevalence and potential risk factors of SBI and WMH in young patients with first-ever stroke.A total of 400 young patients with first-ever stroke were included in this study and received magnetic resonance imaging test. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000013311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283195PMC
November 2018
6 Reads

[Lumbosacral radiculoplexus neuropathy with a small intramedullary lesion in posterior spinal cord: a case report].

Authors:
Motomi Arai

Rinsho Shinkeigaku 2018 Dec 29;58(12):745-749. Epub 2018 Nov 29.

Department of Neurology, Seirei Mikatahara General Hospital.

We present the unique case of a patient with lumbosacral radiculoplexus neuropathy (LRPN) and a small intramedullary lesion, probably an infarction, in the spinal cord. A previously healthy 58-year-old female developed acute severe pain involving the entire right lower limb, followed by weakness of the right lower limb a few hours later. The patient could not walk and was referred to our clinic. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5692/clinicalneurol.cn-001213DOI Listing
December 2018
2 Reads

[Surgical Experience of Total Arch Replacement Using Frozen Elephant Trunk, for Type B Acute Aortic Dissection].

Kyobu Geka 2018 11;71(12):989-994

Department of Cardiovascular Surgery, Yokohama Rosai Hospital, Yokohama, Japan.

Recently, advanced technique and device of thoracic endovascular aortic repair (TEVAR) enabled surgical intervention for type B acute aortic dissection (BAD). However, BAD have often serious complications;cerebral infarction, spinal cord infarction, multi-organ ischemia or necrosis, and retrograde type A acute aortic dissection. TEVAR is performed for complicated BAD for the aim of life saving in such a failure case of conservative treatment. Read More

View Article

Download full-text PDF

Source
November 2018
10 Reads

Alterations in the spinal cord and ventral root after cerebral infarction in non-human primates.

Restor Neurol Neurosci 2018 ;36(6):729-740

Department of Neurology and Stroke Center, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Backgrounds: Cerebral infarction does not only cause focal injury in the ischemic site, but also secondary non-ischemic damage at the remote areas of nervous system associated with the primary focus.

Objective: This study investigated the changes in the spinal cord and ventral root after middle cerebral artery occlusion (MCAO) in cynomolgus monkeys (Macaca fascicularis).

Methods: Adult male cynonolgus monkeys (4-5 years, 5. Read More

View Article

Download full-text PDF

Source
http://www.medra.org/servlet/aliasResolver?alias=iospress&am
Publisher Site
http://dx.doi.org/10.3233/RNN-180854DOI Listing
April 2019
23 Reads

Paraplegia After Basketball Play: A Case of Spinal Cord Infarction Secondary to Fibrocartilaginous Embolization.

Pediatr Emerg Care 2018 Nov 5. Epub 2018 Nov 5.

Departments of Medical Education and Pediatrics, Section of General Pediatrics, West Virginia University School of Medicine, Morgantown, WV.

Pediatric emergency medicine providers must be astute at generating the differential diagnosis and performing the appropriate evaluation to promptly determine the underlying cause of new onset paraplegia. Spinal cord infarction (SCI) is a potential etiology of paraplegia in children, and fibrocartilaginous embolization is a rare underlying cause of SCI. We present an illustrative case of SCI secondary to fibrocartilaginous embolization in an otherwise healthy adolescent who developed symptoms of spinal cord dysfunction after basketball play. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PEC.0000000000001666DOI Listing
November 2018

Delayed-Onset Paraplegia Due to Spinal Cord Infarction After Repeated Tumor Excision Surgeries of the Thoracic Spine.

Orthopedics 2019 Jan 29;42(1):e131-e134. Epub 2018 Oct 29.

Tumor excision surgeries of the spine present a distinct challenge regarding the maintenance of spinal cord blood supply because they often require preoperative embolization of segmental arteries, ligation of the corresponding nerve roots, and circumferential exposure of the dural sac. The authors present a case of delayed-onset spinal cord infarction after repeated tumor excision surgeries of the thoracic spine. A 49-year-old man had undergone a left nephrectomy for renal cell carcinoma, 2 pulmonary metastasectomies, and excision of a left sixth rib metastasis before referral to the authors' institution. Read More

View Article

Download full-text PDF

Source
https://www.healio.com/doiresolver?doi=10.3928/01477447-2018
Publisher Site
http://dx.doi.org/10.3928/01477447-20181023-07DOI Listing
January 2019
5 Reads

Anterior spinal cord syndrome as a rare complication of acute bacterial meningitis in an adult.

BMJ Case Rep 2018 Oct 24;2018. Epub 2018 Oct 24.

Department of Medicine (Neurology), School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

Acute bacterial meningitis is not an uncommon central nervous system infection. In severe cases, it can be associated with various neurological or systemic complications. However, acute spinal cord dysfunction rarely occurs. Read More

View Article

Download full-text PDF

Source
http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22608
Publisher Site
http://dx.doi.org/10.1136/bcr-2018-226082DOI Listing
October 2018
9 Reads

Spinal Cord Infarction Because of Spontaneous Vertebral Artery Dissection.

Stroke 2018 Nov;49(11):e314-e317

From the Department of Neurology, Warren Alpert Medical School of Brown University, Providence, RI (M.M., A.B., I.A., L.K., S.Y.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/STROKEAHA.118.022333DOI Listing
November 2018
4 Reads

Sudden Collapse due to Medullary and Cervical Cord Infarction-An Unusual Presentation of Hepatocellular Carcinoma.

J Forensic Sci 2018 Oct 23. Epub 2018 Oct 23.

Department of Anatomical Pathology, Singapore General Hospital, 20 College Road, Singapore, 169856, Singapore.

Hepatocellular carcinoma (HCC) is a common cancer worldwide with a great potential for metastatic spread. Hepatocellular carcinoma often arises in people with underlying viral hepatitides or liver cirrhosis and may present in various ways including abdominal pain, liver mass, and signs of hepatocellular decompensation. Many tumors may have metastasized to other organs such as the lungs, lymph nodes, bone, and adrenal glands at the time of diagnosis. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/1556-4029.13929
Publisher Site
http://dx.doi.org/10.1111/1556-4029.13929DOI Listing
October 2018
10 Reads

Leukemia inhibitory factor modulates the peripheral immune response in a rat model of emergent large vessel occlusion.

J Neuroinflammation 2018 Oct 15;15(1):288. Epub 2018 Oct 15.

Department of Neurology, University of Kentucky, 741 S. Limestone BBSRB B457, Lexington, KY, 40536-0905, USA.

Background: The migration of peripheral immune cells and splenocytes to the ischemic brain is one of the major causes of delayed neuroinflammation after permanent large vessel stroke. Other groups have demonstrated that leukemia inhibitory factor (LIF), a cytokine that promotes neural cell survival through upregulation of antioxidant enzymes, promotes an anti-inflammatory phenotype in several types of immune cells. The goal of this study was to determine whether LIF treatment modulates the peripheral immune response after stroke. Read More

View Article

Download full-text PDF

Source
https://jneuroinflammation.biomedcentral.com/articles/10.118
Publisher Site
http://dx.doi.org/10.1186/s12974-018-1326-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190542PMC
October 2018
21 Reads

Spinal cord infarction with ipsilateral segmental neuropathic pain and flaccid paralysis. A functional role for human afferent ventral root small sensory fibres.

J Neurol Sci 2018 12 1;395:84-87. Epub 2018 Oct 1.

Faculad de Medicina, Universidad de Chile, Chile; Imperial College, London, UK.

This paper illustrates the cases of two patients with an acute onset of right brachial neuropathic pain, flaccid paralysis and contralateral thermal and thermal pain hypoesthesia, without posterior column impairment nor pyramidal signs below the segmental lesion. MRI showed right sided spinal cord infarction, in the anterior spinal artery territory between C1 and C5 in one patient and between C3 and C7 in the other. Contact Heat Evoked Potentials and Quantitative Thermal Sensory testing are consistent with contralateral, but not ipsilateral, spinothalamic tract involvement. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0022510X183039
Publisher Site
http://dx.doi.org/10.1016/j.jns.2018.09.037DOI Listing
December 2018
3 Reads

Cerebrospinal fluid drainage and blood pressure elevation to treat acute spinal cord infarct.

Surg Neurol Int 2018 21;9:195. Epub 2018 Sep 21.

Cerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Background: Current management of acute spinal cord infarction (SCI) is limited. Lumbar cerebrospinal fluid drainage (CSFD) with blood pressure augmentation is utilized in the thoracic/thoracoabdominal aortic repair and thoracic endovascular aortic repair (TEVAR) populations to increase spinal perfusion pressure.

Case Description: We identified 3 patients who sustained acute SCI and underwent CSFD and maintenance of elevated mean arterial pressure (MAP) within 24 hours of injury. Read More

View Article

Download full-text PDF

Source
http://surgicalneurologyint.com/surgicalint-articles/cerebro
Publisher Site
http://dx.doi.org/10.4103/sni.sni_2_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169349PMC
September 2018
5 Reads

Characteristics of Spontaneous Spinal Cord Infarction and Proposed Diagnostic Criteria.

JAMA Neurol 2019 Jan;76(1):56-63

Department of Neurology, Mayo Clinic, Rochester, Minnesota.

Importance: Spinal cord infarction (SCI) is often disabling, and the diagnosis can be challenging without an inciting event (eg, aortic surgery). Patients with a spontaneous SCI are often misdiagnosed as having transverse myelitis. Diagnostic criteria for SCI are lacking, hindering clinical care and research. Read More

View Article

Download full-text PDF

Source
http://archneur.jamanetwork.com/article.aspx?doi=10.1001/jam
Publisher Site
http://dx.doi.org/10.1001/jamaneurol.2018.2734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440254PMC
January 2019
14 Reads

Microsurgical Management of a Spinal Dural Arteriovenous Fistula With Shared Blood Supply to the Artery of Adamkiewicz: 3-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2018 Sep 24. Epub 2018 Sep 24.

Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia.

The presented case is of a 65-yr-old gentleman referred for thoracic myelopathy. He developed bilateral, nondermatomal foot dysesthesia 14 mo prior to presentation, which progressed to numbness below the L3 level. He reported progressive gait instability, bilateral lower extremity weakness, and required a cane for ambulation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ons/opy293DOI Listing
September 2018
7 Reads

[Effect of spinal cord stimulation on myocardial ischemia/infarction].

Zhejiang Da Xue Xue Bao Yi Xue Ban 2018 May;47(2):201-206

Department of Cardiology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

Fatal arrhythmias, heart failure, and sudden cardiac death after myocardial ischemia/infarction are serious threats to human health. In recent years, studies have shown that spinal cord stimulation (SCS) can balance autonomic activity, inhibit myocardial structural remodeling, improve blood flow to ischemic myocardium, effectively reduce the incidence of arrhythmia, heart failure and sudden cardiac death after myocardial ischemia/infarction, but its specific mechanism has not yet been fully elucidated. The effect of SCS on cardiac function may be achieved by inhibiting neural remodeling, or by ameliorating structural remodeling and electrical remodeling. Read More

View Article

Download full-text PDF

Source

Towards rationally designed biomanufacturing of therapeutic extracellular vesicles: impact of the bioproduction microenvironment.

Biotechnol Adv 2018 12 12;36(8):2051-2059. Epub 2018 Sep 12.

Fischell Department of Bioengineering, University of Maryland, 3102 A. James Clark Hall, College Park, MD 20742, United States; Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, Baltimore, MD 21201, United States; Program in Molecular and Cell Biology, University of Maryland, College Park, MD 20742, United States. Electronic address:

Extracellular vesicles (EVs), including exosomes, microvesicles, and others, have emerged as potential therapeutics for a variety of applications. Pre-clinical reports of EV efficacy in treatment of non-healing wounds, myocardial infarction, osteoarthritis, traumatic brain injury, spinal cord injury, and many other injuries and diseases demonstrate the versatility of this nascent therapeutic modality. EVs have also been demonstrated to be effective in humans, and clinical trials are underway to further explore their potential. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07349750183015
Publisher Site
http://dx.doi.org/10.1016/j.biotechadv.2018.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250573PMC
December 2018
40 Reads

Methods for Assessing Serpins as Neuroprotective Therapeutics.

Authors:
Jacek M Kwiecien

Methods Mol Biol 2018 ;1826:223-235

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.

As the systematic work on the pathogenesis of the white matter injury in the spinal cord models progresses, it becomes obvious that a severe and extraordinarily protracted, destructive inflammation follows the initial injury. Appropriate anti-inflammatory therapies of sufficient duration should not only inhibit but also lead to the elimination of this destructive inflammation, thus resulting in neuroprotection of the spinal cord tissue and a greater preservation of the neurologic function. While dexamethasone, a powerful, anti-inflammatory steroid analog administered continuously by subdural infusion for 7 days inhibited severe macrophage infiltration in the cavity of injury, the dose used was remarkably toxic. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-8645-3_15DOI Listing
March 2019
2 Reads

Delayed cerebellar infarction after a slight electric injury.

Am J Emerg Med 2018 Dec 27;36(12):2337.e3-2337.e5. Epub 2018 Aug 27.

ICU, Ningbo Medical Center Lihuili Eastern Hospital, No 1111, Jiangnan Rd, Ningbo 315100, China. Electronic address:

Electrical injury causes direct damage to nerves. It may manifest as peripheral nerve injury, spinal cord damage, cerebellar ataxia, hypoxic encephalopathy, or intracerebral hemorrhage. Various factors determine the severity of electric injury, including type of current, amperage, voltage, tissue resistance, pathway of the current, and duration of contact with the body. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07356757183071
Publisher Site
http://dx.doi.org/10.1016/j.ajem.2018.08.064DOI Listing
December 2018
17 Reads

Deep chronic microvascular white matter ischemic change as an independent predictor of acute brain infarction after thoracic aortic replacement.

J Card Surg 2018 Sep 2;33(9):552-560. Epub 2018 Sep 2.

Department of Neuroradiology, Imaging Institute, Cleveland Clinic, Cleveland, Ohio.

Background: Postoperative brain injury is a cause of mortality and morbidity in patients who undergo thoracic aortic replacement. Chronic microvascular white matter ischemic change (WMIC) has been shown to be associated with acute brain infarction in the general population. WMIC has also been shown to be an independent predictor of non-focal neurocognitive changes, generalized seizures, and temporary neurologic dysfunction in patients who undergo thoracic aortic replacement. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/jocs.13786
Publisher Site
http://dx.doi.org/10.1111/jocs.13786DOI Listing
September 2018
9 Reads
0.890 Impact Factor

Spinal cord infarction during physical exertion due to polycythemia vera and aortoiliac occlusive disease: A case report.

Medicine (Baltimore) 2018 Aug;97(35):e12181

Department of Physical Medicine and Rehabilitation, National Cheng Kung University Hospital.

Rationale: Spinal cord infarction is rarely caused by hypercoagulable states. Polycythemia vera (PV) is a myeloproliferative neoplasm that can contribute to thrombotic events due to increased blood viscosity. We report a case of spinal cord infarction due to extensive aortic thrombosis caused by PV. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000012181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392751PMC
August 2018
5 Reads

Microsurgical Excision of T12-L1 Pial Arteriovenous Malformation: 3-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2019 Mar;16(3):E85

Department of Neurosurgery, University of Washington, Seattle, Washington.

This 29-yr-old man presented with progressive paraparesis, sensory loss, allodynia, bowel, and bladder dysfunction for 9 mo, acutely exacerbated in the preceding 24 h. Magnetic resonance imaging scan showed multiple dilated vessels involving the thoracic cord. Spinal angiogram revealed a T12-L1 pial arteriovenous malformation (AVM)/arteriovenous fistula on the left side. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/ons/advance-article/doi/10.1093/ons
Publisher Site
http://dx.doi.org/10.1093/ons/opy243DOI Listing
March 2019
19 Reads

Towards BCI-actuated smart wheelchair system.

Biomed Eng Online 2018 Aug 20;17(1):111. Epub 2018 Aug 20.

College of Artificial Intelligence, National University of Defense Technology, Deya Road, Changsha, 410000, People's Republic of China.

Background: Electroencephalogram-based brain-computer interfaces (BCIs) represent novel human machine interactive technology that allows people to communicate and interact with the external world without relying on their peripheral muscles and nervous system. Among BCI systems, brain-actuated wheelchairs are promising systems for the rehabilitation of severely motor disabled individuals who are unable to control a wheelchair by conventional interfaces. Previous related studies realized the easy use of brain-actuated wheelchairs that enable people to navigate the wheelchair through simple commands; however, these systems rely on offline calibration of the environment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12938-018-0545-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102906PMC
August 2018
20 Reads