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BMJ Case Rep 2020 Jun 30;13(6). Epub 2020 Jun 30.

Cardiology, University of Louisville, Louisville, Kentucky, USA.

Acute ischaemic stroke is a known risk of percutaneous coronary intervention (PCI). The incidence of such complications has increased in frequency over the last decade due to higher comorbidity burden and increased complexity of PCI procedures. The overall incidence of post-PCI ischaemic stroke remains low at 0. Read More

Ann Vasc Dis 2020 Jun;13(2):176-179

Department of Radiology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.

An 80-year-old woman presented with abdominal and right lower limb pain. Radiological examination revealed pelvic arteriovenous malformations (pAVMs). Although transarterial embolization was repeated, dilation of the common iliac vein worsened. Read More

Acta Neurol Belg 2020 Jun 25. Epub 2020 Jun 25.

Department of Neurology, AZ KLINA, Augustijnslei 100, 2930, Brasschaat, Belgium.

JAMA Neurol 2020 Jun 22. Epub 2020 Jun 22.

Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

J Neurosurg Spine 2020 Jun 12:1-8. Epub 2020 Jun 12.

Objective: Degenerative cervical myelopathy (DCM) is the most common cause of spinal cord dysfunction in adults. Multilevel ventral compressive pathology is routinely managed through anterior decompression and reconstruction, but there remains uncertainty regarding the relative safety and efficacy of multiple discectomies, multiple corpectomies, or hybrid corpectomy-discectomy. To that end, using a large national administrative healthcare data set, the authors sought to compare the perioperative outcomes of anterior cervical discectomy and fusion (ACDF), anterior cervical corpectomy and fusion (ACCF), and hybrid corpectomy-discectomy for multilevel DCM. Read More

Ann Thorac Surg 2020 Jun 3. Epub 2020 Jun 3.

Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA. Electronic address:

Background: Contemporary outcomes of open repair of thoracoabdominal aortic (TAAAs) and descending thoracic aortic aneurysms (DTAs) have not been analyzed in an inclusive meta-analysis.

Methods: Following a systematic literature search, studies from 2008 to 2018 reporting outcomes of open repair of descending thoracic aortic aneurysms or thoracoabdominal aortic aneurysms were pooled in a single-arm meta-analysis performed using the generic inverse variance method. The primary outcome was operative mortality. Read More

Vasc Endovascular Surg 2020 Jun 4:1538574420929135. Epub 2020 Jun 4.

Department of Surgery, Robert C. Byrd Health Sciences Center/West Virginia University, Charleston Area Medical Center, Vascular Center of Excellence, WV, USA.

Purpose: Our objective was to determine significant predictors of spinal cord ischemia (SCI) following Thoracic Endovascular Aortic Repair (TEVAR) and to further develop a simple and clinically orientated risk score model.

Methods: A retrospective review of data from the Society of Vascular Surgery/Vascular Quality Initiative national data set was performed for all patients undergoing TEVAR from January, 2014 to June 2018. Preoperative demographics, procedure-related variables, and clinical details related to SCI were examined. Read More

Neuroradiology 2020 Jun 2. Epub 2020 Jun 2.

Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.

Purpose: Endovascular therapy to the spinal dural arteriovenous fistula (SDAVF) with a common origin of the radiculomedullary artery and the feeder of the shunt has the risk of spinal cord infarction. This study aimed to retrospectively assess the detection rate of normal spinal arteries from the feeder of SDAVF.

Methods: We retrospectively collected the angiographic and clinical data of SDAVFs. Read More

Medicine (Baltimore) 2020 May;99(22):e20282

Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University 317-1, Daemyungdong, Namku, Taegu, Republic of Korea.

Introduction: The aberrant pyramidal tract (APT) refers to the collateral pathway of the pyramidal tract (PT) descending through the medial lemniscus in the midbrain and pons. We report on a patient who showed changes of the APT from the early stage to the chronic stage concurrent with motor recovery following an infarct in the cerebral peduncle.

Patient Concerns: An 84-year-old female patient presented with moderate motor weakness of her upper and lower extremities (2/2) due to cerebral infarct on the right cerebral peduncle of midbrain. Read More

J Artif Organs 2020 May 30. Epub 2020 May 30.

Hopital Universitaire Pitie Salpetriere, Paris, France.

Spinal cord infarction (SCI) is a rare disease among central nervous system vascular diseases. Only a little is known about venoarterial extracorporeal membrane oxygenation (VA-ECMO)-related SCI. Retrospective observational study conducted, from 2006 to 2019, in a tertiary referral center on patients who developed VA-ECMO-related neurovascular complications, focusing on SCI. Read More

J Clin Neurosci 2020 Jul 11;77:222-224. Epub 2020 May 11.

Department of Neurology, Rouen University Hospital and University of Rouen, 76031 Rouen Cedex, France. Electronic address:

Fibrocartilaginous embolism (FCE) is a rare and probably under diagnosed cause of spinal cord infarction presumably due to acute embolization of nucleus pulposus fragments into the spinal circulation. Concomitant cerebral involvement is much rarer and often asymptomatic. Although the definitive diagnosis is histologic, certain criteria have been proposed to support the diagnosis in living patients, such as absence of vascular risk factors, acute onset or antecedent of valsalva maneuver before the episode and the exclusion of potential differential diagnoses. Read More

Spine (Phila Pa 1976) 2020 May;45(10):673-678

Mumbai Spine Scoliosis and Disc Replacement Centre, Bombay Hospital and Medical Research Center, Mumbai, India.

Study Design: Cohort.

Objective: To evaluate perioperative morbidity in patients undergoing minimally invasive spine surgery of the lumbar spine while continuing the antiplatelet drug (APD) perioperatively as compared with those not continuing these drugs and those not on these drugs.

Summary Of Background Data: While discontinuation of antiplatelet drugs carries with it the risk of thrombosis of the cardiac stents, myocardial infarction, peripheral vascular occlusion, cerebro-vascular events and other thrombotic complications, continuation of these drugs has the risk of intra spinal bleeding and the serious consequences of subsequent epidural hematoma with associated spinal cord compression. Read More

R I Med J (2013) 2020 May 1;103(4):52-54. Epub 2020 May 1.

Department of Neurosurgery, The Warren Alpert Medical School of Brown University, Providence.

The authors report the case of an 82-year-old woman with a spinal epidural hematoma following attempted catheter-directed thrombolysis of a large femoral- popliteal deep venous thrombosis. The patient rapidly developed acute motor and sensory paralysis below the level of T7 within hours of the thrombectomy procedure. Computed tomography imaging revealed that the catheter had perforated the wall of the right inferior vena cava and magnetic resonance imaging subsequently demonstrated an extensive T1-S1 dorsal epidural hematoma with compression of the thoracic spinal cord, conus medullaris, and cauda equina. Read More

J Vasc Surg 2020 Apr 23. Epub 2020 Apr 23.

Sanford Health - Vascular Surgery, 1305 W 18(th)Street Sioux Falls, SD USA 57117. Electronic address:

Objective: To review the 30-day and one-year clinical results of the use of the investigational Unitary Manifold (UM) Stent Graft System for the repair of Crawford type IV, pararenal, paravisceral, juxtarenal, and short-neck infrarenal aneurysms (<10 mm).

Methods: A single-center, multi-arm, prospective review of the first 44 patients who underwent repair of Crawford type IV, pararenal, juxtarenal, and short-neck infrarenal aneurysms (<10 mm) using the physician-modified UM under a physician-sponsored investigational device exemption. The primary endpoint was freedom from major adverse events at 30 days, including all-cause mortality, myocardial infarction, stroke, paraplegia, bowel ischemia, respiratory failure, and renal failure. Read More

Medicine (Baltimore) 2020 Apr;99(16):e19835

Department of Physical Therapy, College of Health Sciences, Dankook University.

Rationale: Pusher syndrome is a disorder of postural control. It is associated with unilateral lesions on central vestibular system. In the current study, we attempted to identify and investigate neural connectivity of the parieto-insular vestibular cortex in a patient with pusher syndrome, using diffusion tensor imaging. Read More

World Neurosurg 2020 Apr 17;139:151-157. Epub 2020 Apr 17.

Department of Neurological Surgery, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.

Objective: Paralysis (paraplegia or quadriplegia) after posterior fossa surgery is a rare but devastating complication. We investigated previous reports of this complication to examine similarities among patients, risk factors, and methods by which it may be prevented.

Methods: A systematic review was completed according to PRISMA guidelines. Read More

Curr Pharm Biotechnol 2020 Apr 16. Epub 2020 Apr 16.

Shobhaben Pratapbhai Patel School Pharmacy and Technology Management SVKM'S NMIMS, V.L Mehta Road, Vile Parle(W), Mumbai. India.

Background: Stem cells are of two types: embryonic and adult stem cells and they act as a repair system by replenishing body tissue. Stem cells differentiate into different types of cells, such as neural, hematopoietic, adipose, etc. and are used for the treatment of various conditions like myocardial infarction, spinal cord injury, Parkinson's disease and diabetes. Read More

Spine Deform 2020 Apr 9. Epub 2020 Apr 9.

Nicklaus Children's Hospital, 3100 SW 62nd Ave., Miami, FL, 33165, USA.

Study Design: A multicenter retrospective IRB exempt case series analyzing clinical and radiographical data of patients treated by three surgeons over the past two decades was conducted.

Objective: To examine the factors involved in the development of quadriparesis in patients who underwent posterior spinal fusion for scoliosis. Delayed spinal cord infarcts usually present at the region of instrumentation according to reports from the Scoliosis Research Society. Read More

J Vasc Surg 2020 Apr 4. Epub 2020 Apr 4.

Division of Vascular Surgery, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Background: In thoracic endovascular aortic repair (TEVAR), covering the celiac artery (CA) is sometimes necessary to secure the distal seal. We report the outcomes of planned CA coverage in our experience with TEVAR.

Methods: Cases requiring CA coverage during TEVAR from October 2008 to September 2018 were retrospectively reviewed. Read More

Tidsskr Nor Laegeforen 2020 Mar 30;140(5). Epub 2020 Mar 30.

Background: Fibrocartilaginous embolism (FCE) is a rare cause of spinal cord infarction. Most spinal cord infarctions are due to aortic pathologies and aortic surgeries. One theory is that material from the intervertebral discs follows a retrograde route to the anterior spinal artery. Read More

Neurol Neurochir Pol 2020 27;54(2):209-210. Epub 2020 Mar 27.

Department of Neurology, Medical University of Bialystok, Bialystok, Poland.

J Neurosurg 2020 Mar 27:1-10. Epub 2020 Mar 27.

10Department of Neurosurgery, Geisinger Health System, Danville, Pennsylvania; and.

Objective: Coverage of the anterior spinal artery (ASA) ostia is a source of considerable consternation regarding flow diversion (FD) in vertebral artery (VA) aneurysms due to cord supply. The authors sought to assess the association between coverage of the ASA, posterior spinal artery (PSA), or lateral spinal artery (LSA) ostia when placing flow diverters in distal VAs and clinical outcomes, with emphasis on cord infarction.

Methods: A multicenter retrospective study of 7 institutions in which VA aneurysms were treated with FD between 2011 and 2019 was performed. Read More

Am J Case Rep 2020 Mar 12;21:e920213. Epub 2020 Mar 12.

Department of Neurosurgery, Agia Sophia, Pediatric Hospital, Athens, Greece.

BACKGROUND Various factors have been implicated in the pathogenesis of infarction after posterior fossa surgery such as venous air embolism, patient's position (seated or prone), hyperflexion of the neck, excessive spinal cord traction, cervical canal stenosis, and systemic arterial hypotension. The main aim of this case report was to elucidate a case in which hydrogen peroxide was implicated in a major and systemic complication after a neurosurgical procedure. CASE REPORT We describe the case of a 5-year-old female patient who was admitted to our hospital because of a cerebellar hemispheric astrocytoma associated with obstructive hydrocephalus and accompanied by 2 syringomyelic cavities in the cervicothoracic portion of the spinal cord. Read More

Acta Neurochir (Wien) 2020 Jun 10;162(6):1445-1453. Epub 2020 Mar 10.

Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Topeliuksenkatu 5, PO. Box 266, 00029, Helsinki, Finland.

Background: Blunt cerebrovascular injuries (BCVIs) and cervical spinal injuries (CSIs) are not uncommon injuries in patients with severe head injury and may affect patient recovery. We aimed to assess the independent relationship between BCVI, CSI, and outcome in patients with severe head injury.

Methods: We identified patients with severe head injury from the Helsinki Trauma Registry treated during 2015-2017 in a large level 1 trauma hospital. Read More

Zhen Ci Yan Jiu 2020 Feb;45(2):141-7

Department of Traditional Chinese Medicine, People's Hospital of Peking University, Beijing 100044, China.

Objective: To observe the intervention effect of acupuncture at the anterior oblique parietotemporal line on gray matter remodeling in patients with hemiplegia of cerebral infarction based on voxel-based morphology (VBM), and to reveal the advantages and central effect sites of scalp acupuncture for hemiplegia of cerebral infarction.

Methods: A total of 18 patients with hemiplegia of cerebral infarction in the right basal ganglia and 18 healthy subjects were enrolled and T1 structural scan was performed. The patients were randomly divided into scalp acupuncture group and non-scalp acupuncture group, with 9 patients in each group. Read More

World Neurosurg 2020 Mar;135:375-376

Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan; Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA; Center for Neuroscience and Regeneration Research, VA Connecticut Healthcare System, West Haven, Connecticut, USA.

J Neurosci Rural Pract 2020 Jan 5;11(1):191-195. Epub 2019 Dec 5.

3rd Cardiology Department, Hippokrateio University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Spontaneous spinal epidural hematoma (SSEH) is a rare, albeit well-documented complication following thrombolysis treatment in ST elevation myocardial infarction (STEMI). A SSEH usually manifests with cervical pain and neurologic deficits and may require surgical intervention. In this case report, we present the first reported SSEH to occur following thrombolysis with reteplase. Read More

Clin Anat 2020 Mar 2. Epub 2020 Mar 2.

Cardiovascular Surgery, Heart Center Freiburg University, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Introduction: Spinal cord ischemia after cardiovascular interventions continues to be a devastating problem in modern surgery. The role of intraspinal vascular networks and anterior radiculomedullary arteries (ARMA) in preventing spinal cord ischemia is poorly understood.

Materials And Methods: Landrace pigs (n = 30, 35. Read More

Acta Chir Belg 2020 Feb 13:1-4. Epub 2020 Feb 13.

Division of Gastroenterology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Transarterial chemoembolisation (TACE) is considered standard treatment for intermediate-stage hepatocellular carcinoma (HCC). Although TACE is viewed as a safe and effective procedure, it may still present with various complications, including spinal cord injury, though very rarely. A 74-year-old male was diagnosed with non-B, non-C HCC, segment 4, cT2N0M0, AJCC stage II, BCLC stage B. Read More

Medicine (Baltimore) 2020 Jan;99(4):e18865

Department of Emergency, Jining NO.1 People's Hospital, Jining, Shandong, China.

This study aimed to explore the risk factors for severity of white matter lesions and its correlation with in the elderly with lacunar infarction.Patients (range, 70-85 years) with lacunar infarction treated in a hospital in China from 2016 to 2017were enrolled. Fazekas rating scale (0-6 points) was used to assess severity of white matter lesions. Read More

PLoS One 2020 21;15(1):e0221851. Epub 2020 Jan 21.

Department of Physiology Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.

Background: There is currently no effective treatment for promoting regeneration of injured nerves in patients who have sustained injury to the central nervous system such as spinal cord injury. Chondroitinase ABC is an enzyme, which promotes neurite outgrowth and regeneration. It has shown considerable promise as a therapy for these conditions. Read More

J Spinal Cord Med 2020 Jan 16:1-4. Epub 2020 Jan 16.

Neurology Department, Hospital Clínic de Barcelona, Barcelona, Spain.

Spinal cord infarction is a rare condition that develops as a result of insufficient vascular perfusion, sometimes related to procedures involving the aorta and vertebral arteries. We present the case of a 66-year-old woman who developed weakness on all four extremities and thermalgesic sensory deficit following an elective endovascular embolization of an incidentally diagnosed aneurysm in the posterior circulation. The procedure involved the cathetherization of both vertebral arteries, but was unremarkable and the flow into the anterior spinal artery was preserved. Read More

Ann Vasc Dis 2019 Dec;12(4):524-529

Department of Surgery, Division of Vascular Surgery, Tohoku University Hospital, Sendai, Miyagi, Japan.

: The optimal surgical management for primary infected abdominal aortic aneurysm (IAAA) is controversial. Here, we report the early and long-term results of surgical treatments with the resection of the IAAA and in situ graft reconstruction with pedicled omental coverage that was performed at out hospital. : Between 2010 and 2017, 27 consecutive patients (26 males, 1 female, median age 69 years) with IAAA were surgically treated with the resection of the IAAA, in situ graft reconstruction and covered with a pedicled omental flap. Read More

J Thorac Cardiovasc Surg 2019 Nov 22. Epub 2019 Nov 22.

Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY.

Objective: To discern the impact of depressed left ventricular ejection fraction (LVEF) on the outcomes of open descending thoracic aneurysm (DTA) and thoracoabdominal aneurysms (TAAA) repair.

Methods: Restricted cubic spline analysis was used to identify a threshold of LVEF, which corresponded to an increase in operative mortality and major adverse events (MAE: operative death, myocardial infarction, stroke, spinal cord injury, need for tracheostomy or dialysis). Logistic and Cox regression were performed to identify independent predictors of MAE, operative mortality, and survival. Read More

Nihon Yakurigaku Zasshi 2020 ;155(1):16-19

Department of Urology, Graduate School of Medicine, University of the Ryukyus.

Stress urinary incontinence (SUI) is a common and bothersome problem among middle-aged women. However, there are few useful drugs for SUI. Urethral hypermobility and intrinsic sphincter deficiency are two main causes of SUI. Read More

J Vasc Surg 2019 Dec 24. Epub 2019 Dec 24.

Division of Vascular and Endovascular Surgery, University of Washington, Seattle, Wash.

Objective: The objective of this study was to analyze outcomes of fenestrated-branched endovascular aneurysm repair (F/BEVAR) for treatment of postdissection and degenerative thoracoabdominal aortic aneurysms (TAAAs).

Methods: We reviewed the clinical data of 240 patients with extent I to extent III TAAAs enrolled in seven prospective physician-sponsored investigational device exemption studies from 2014 to 2017. All patients had manufactured off-the-shelf or patient-specific fenestrated-branched stent grafts used to target 888 renal-mesenteric arteries with a mean of 3. Read More

J Neurosurg Spine 2019 Dec 20:1-7. Epub 2019 Dec 20.

Departments of1Neurosurgery and.

Paraplegia after posterior fossa surgery is a rare and devastating complication. The authors reviewed a case of paraplegia following Chiari decompression and surveyed the literature to identify strategies to reduce the occurrence of such events.An obese 44-year-old woman had progressive left arm pain, weakness, and numbness and tussive headaches. Read More

BMC Neurol 2019 Dec 17;19(1):328. Epub 2019 Dec 17.

Department of Neurology, Chang Gung Memorial Hospital at Linkou Medical Center, Taoyuan, Taiwan.

Background: Spontaneous conus medullaris infarction is a rare disease. We describe two patients with spontaneous conus medullaris infarction presenting as acute cauda equina syndrome and their unique electromyography (EMG) findings.

Case Presentation: Two patients developed acute low back pain with mild asymmetric paraparesis, loss of perianal sensation and sphincter dysfunction. Read More

A A Pract 2020 Feb;14(3):79-82

Department of Intensive Care Medicine, St Georges Hospital, London, United Kingdom.

We describe a hepatic laceration and subsequent anterior spinal artery syndrome in a 21-year-old man, secondary to prolonged cardiopulmonary resuscitation with a Lund University Cardiac Assist System (LUCAS2) mechanical cardiac compression device. We briefly review the current literature pertaining to hepatic injury from trauma due to cardiopulmonary resuscitation. The etiology of the anterior spinal artery syndrome in this patient is discussed. Read More

J Neurosurg Spine 2019 Dec 13:1-4. Epub 2019 Dec 13.

3Department of Radiology, Bahcesehir University School of Medicine, Istanbul, Turkey.

The evaluation of spinal cord vascular malformations in neuroradiology departments remains valid for both diagnosis and endovascular embolization, and for adjuvant as well as definitive treatment. The most commonly encountered complications of endovascular approaches are the recurrence or the incomplete embolization of the lesion and accidental damage to the medullary arteries, which leads to spinal cord infarction. Failure to remember a microcatheter in the abdominal aorta after catheterization is an underestimated complication. Read More

ACG Case Rep J 2019 Oct 15;6(10):e00238. Epub 2019 Oct 15.

Department of Pathology, Thomas Jefferson University Hospital, Philadelphia, PA.

Epstein-Barr virus (EBV) is a member of the herpesvirus family that is associated with various disease manifestations, including EBV-associated colitis. There are few case reports describing hemorrhage associated with EBV colitis. We report a 61-year-old woman with acute gastrointestinal bleeding due to EBV colitis after initiation of methylprednisolone and enoxaparin for spinal cord infarction. Read More

BMC Neurol 2019 Dec 12;19(1):321. Epub 2019 Dec 12.

Department of Radiology, the First Hospital of JiLin University, Xinmin St. #71, Changchun, 130021, China.

Background: Spinal cord infarction (SCI) is rarely caused by vertebral artery dissection (VAD), which is an important cause of posterior circulation stroke in young and middle-aged patients. We report the case of a middle-aged patient without obvious risk factors for atherosclerosis who had SCI from right VAD.

Case Presentation: An otherwise healthy 40-year-old man presented with acute right-sided body weakness. Read More

Eur J Pharmacol 2020 Jan 4;867:172836. Epub 2019 Dec 4.

Department of Gerontology, Yijishan Hospital of Wannan Medical College, Wuhu, 241001, PR China; Department of Physiology and Neurobiology, Zhengzhou University School of Medicine, Zhengzhou, 450001, PR China; Department of Pharmacology & Therapeutics and Institute of Neuroscience, Trinity College, Dublin 2, Ireland. Electronic address:

Excessive sympathetic activity is associated with heart failure and ventricular arrhythmias, which regulated by enhanced cardiac sympathetic afferent reflex, which can be blunted by resiniferatoxin, a selective receptor agonist of transient vanilloid potential 1 (TRPV1) + primary sensory afferents. The present study is aimed to determine whether intrathecal resiniferatoxin application affect cardiac sympathetic tone and electrophysiology, furtherly create a new effective strategy to prevent lethal arrhythmias in chronic heart failure. Four weeks after coronary artery occlusion to induce heart failure in rats, RTX (2μg/10 μl) or vehicle was injected intrathecally into the T2/T3 interspace. Read More

Neurology 2020 01 2;94(1):e87-e96. Epub 2019 Dec 2.

From the Department of Neurology (Y.-C. Lee, C.-P.C., S.-J.W., Y.-C. Liao), Taipei Veterans General Hospital; Department of Neurology (Y.-C. Lee, C.-P.C., M.-H.C., S.-J.W., Y.-C. Liao) and Brain Research Center (Y.-C. Lee, S.-J.W., Y.-C. Liao), National Yang-Ming, University School of Medicine, Taipei; and Department of Neurology (M.-H.C.), Taichung Veterans General Hospital, Taiwan.

Objective: To test the hypothesis that the prevalence and clinical effect of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) have been underestimated in Asian populations.

Methods: The Taiwan Biobank, containing 1,517 Taiwanese genome sequences, was queried for pathogenic cysteine-altering mutations. mutations identified in the reference population were genotyped in 7,038 stroke- and dementia-free individuals and 800 patients with ischemic stroke. Read More

J Thorac Cardiovasc Surg 2019 Nov 25. Epub 2019 Nov 25.

Division of Cardiovascular Surgery, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Objective: We sought to determine the early and late outcomes of endovascular versus open thoracoabdominal aortic aneurysm repair.

Methods: We performed a multicenter population-based study across the province of Ontario, Canada, from 2006 to 2017. The primary end point was mortality. Read More

Biochem Pharmacol 2020 01 18;171:113720. Epub 2019 Nov 18.

Jiangsu Key Laboratory of Neuro-Psychiatry Research and Institute of Neuroscience, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China; Key Laboratory of Molecular Pharmacology and Drug Evaluation, School of Pharmacy, Yantai University, Yantai, China. Electronic address:

Stroke is the leading cause of adult disability. Spontaneous functional recovery occurs after ischemic stroke, but it is very limited. Therefore, it is urgent to find a strategy to promote functional recovery after stroke in clinical setting. Read More

Ann Neurol 2020 01 27;87(1):52-62. Epub 2019 Nov 27.

Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö.

Objective: To investigate whether midlife atherosclerosis is associated with different dementia subtypes and related underlying pathologies.

Methods: Participants comprised the cardiovascular cohort of the Swedish prospective population-based Malmö Diet and Cancer Study (N = 6,103). Carotid plaques and intima media thickness (IMT) were measured at baseline (1991-1994). Read More

Spinal Cord Ser Cases 2019 5;5:92. Epub 2019 Nov 5.

2Stoke Mandeville Hospital, Buckinghamshire Healthcare NHS Trust, Aylesbury, UK.

Introduction: Ganglion impar block (GIB) is a well-recognised treatment for chronic coccydynia. Several side effects have previously been described with this procedure, including transient motor dysfunction, bowel, bladder, and sexual dysfunction, neuritis, rectal perforation, impingement of the sciatic nerve, cauda equina syndrome, and infection.

Case Presentation: We describe the first report of imaging-documented conus infarction after an unguided-GIB performed in theatre using particulate steroids for a 17-year-old patient with coccydynia. Read More

Stroke 2020 01 4;51(1):149-153. Epub 2019 Nov 4.

From the Department of Neurology, Peking University First Hospital, Beijing, China (H.J., S.L., Y.S.).

Background and Purpose- Studies on the prevalence and risk factors of white matter lesions (WMLs) in Tibetans living at high altitudes are scarce. We conducted this study to determine the prevalence and risks of WMLs in Tibetan patients without or with nonacute stroke. Methods- We undertook a retrospective analysis of medical records of patients treated at the People's Hospital of Tibetan Autonomous Region and identified a total of 301 Tibetan patients without acute stroke. Read More