Search Our Scientific Publications & Authors

Neurochem Res 2022 Jun 18. Epub 2022 Jun 18.

Département de Biomédecine Vétérinaire, Faculté de Médecine Vétérinaire, Université de Montréal, 3200 Sicotte, Saint-Hyacinthe, QC, J2S 2M2, Canada.

Myocardial infraction (MI) is the principal risk factor for the onset of heart failure (HF). Investigations regarding the physiopathology of MI progression to HF have revealed the concerted engagement of other tissues, such as the autonomic nervous system and the medulla oblongata (MO), giving rise to systemic effects, important in the regulation of heart function. Cardiac sympathetic afferent denervation following application of resiniferatoxin (RTX) attenuates cardiac remodelling and restores cardiac function following MI. Read More

S D Med 2022 Mar;75(3):134-137

Avera McKennan Hospital and University Health Center, Sioux Falls, South Dakota.

White matter changes on MRI can be a diagnostic puzzle as a large group of inflammatory, autoimmune, infectious, and neoplastic conditions can present in this way. An otherwise healthy 36-year-old male presented with his second episode of unilateral weakness, the first episode occurring five years previously. He did not have sensory or cerebellar symptoms with the current or previous episode. Read More

J Vasc Surg 2022 Jun 10. Epub 2022 Jun 10.

Comprehensive Aortic Center, Division of Vascular Surgery and Endovascular Therapy, Keck Medical Center of University of Southern California, Los Angeles, CA. Electronic address:

Introduction: Emergent endovascular repair of suprarenal (SRAAA) and thoracoabdominal aortic aneurysms (TAAA) poses a significant challenge due to the need for branch vessel incorporation, time constraints, and lack of dedicated devices. Techniques to incorporate branch vessels have included parallel grafting (PG), physician modified endografts (PMEG), double-barrel/reversed iliac branch device (DB/rIBE), and in situ fenestration (ISF). This study describes a single-center experience and the associated outcomes when using these techniques for ruptured SRAAA and TAAA. Read More

Transfusion 2022 Jun 6. Epub 2022 Jun 6.

Department of Haematology, Alfred Hospital, Melbourne, Australia.

Mol Neurobiol 2022 May 31. Epub 2022 May 31.

Department of Spine Surgery, Hong Hui Hospital, Xi'an Jiaotong University Health Science Center, No. 555, Youyi East Road, Beilin District, Xi'an, 710054, China.

LncRNA myocardial infarction-associated transcript (MIAT) alleviates acute spinal cord injury (ASCI)-induced neuronal cell apoptosis, but the specific mechanism of it involved in regulating SCI progression needs further exploration. Here, a SCI rat model was established, followed by administration with adenovirus-mediated MIAT overexpression vector (Ad-MIAT) alone or together with Ad-RBFOX2 (RNA binding fox-1 homolog 2). The data indicated that MIAT overexpression promoted motor function recovery, improved morphology of injured tissues, and restrained neuron loss and cell apoptosis in SCI rats. Read More

J Thorac Dis 2022 Apr;14(4):1031-1041

Department of Cardiovascular Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

Background: The frozen elephant trunk technique is useful in aortic arch repair; however, some adverse events are associated with the Frozenix J-graft. We designed a technique to prevent these adverse events and achieve easy anastomosis (Total Exclusion of the Non-Stent part of Frozenix using an Everting anastomosis [TENSE]), and we assessed the outcomes of this technique in the present study.

Methods: From April 2017 to May 2021, 44 patients with aortic arch disease underwent TENSE, in which the proximal stump of the stent part of Frozenix was matched to the distal anastomosis end between the left common carotid and left subclavian arteries. Read More

Case Rep Cardiol 2022 20;2022:2171350. Epub 2022 Apr 20.

Department of Pediatric Cardiology, Hospital de Santa Marta, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal.

In patients with a patent foramen (PFO) who have had a cryptogenic ischemic stroke, percutaneous closure reduces its recurrence risk. However, its role in spinal cord infarction (SCI) is less well-established. A few case reports describe the putative causative role of PFO in SCI. Read More

Cureus 2022 Apr 5;14(4):e23834. Epub 2022 Apr 5.

Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, USA.

A 23-year-old male presented to the hospital with altered mental status (AMS) and hypoglycemia requiring admission to the ICU. He had improvement in AMS after administration of dextrose 50% and naloxone and endorsed the use of alcohol, cocaine, and marijuana that morning. It was confirmed with a positive urine toxicology screen for cocaine and tetrahydrocannabinol (THC). Read More

Front Med (Lausanne) 2022 21;9:792000. Epub 2022 Apr 21.

Department of Anesthesiology, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.

Acute kidney injury (AKI) has been found to be a serious clinical problem with high morbidity and mortality, and is associated with acute inflammatory response and sympathetic activation that subsequently play an important role in the development of AKI. It is well known that the sympathetic nervous system (SNS) and immune system intensely interact and mutually control each other in order to maintain homeostasis in response to stress or injury. Evidence has shown that the superior cervical sympathetic ganglion (SCG) participates in the bidirectional network between the immune and the SNS, and that the superior cervical ganglionectomy has protective effect on myocardial infarction, however, the role of the SCG in the setting of renal ischemic reperfusion injury has not been studied. Read More

Vascular 2022 May 4:17085381221094411. Epub 2022 May 4.

Department of Cardiovascular Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Despite advancements in surgical and postoperative management, spinal cord injury has been a persistent complication of both open and endovascular repair of thoracoabdominal and descending thoracic aortic aneurysm. Spinal cord injury can be explained with an ischemia-infarction model which results in local edema of the spinal cord, damaging its structure and leading to reversible or irreversible loss of its function. Perfusion of the spinal cord during aortic procedures can be enhanced by several adjuncts which have been described with a broad variety of evidence in their support. Read More

Pract Neurol 2022 May 2. Epub 2022 May 2.

Department of Neurology, Gosford Hospital, Gosford, New South Wales, Australia.

Fibrocartilaginous embolism is a rarely reported cause of spinal cord infarction. Seemingly innocuous activities may be associated with nucleus pulposus material embolising to the spinal cord vasculature. We describe a 36-year-old woman presenting with bilateral arm paraesthesia and chest pain that evolved into an acute cord syndrome. Read More

Joint Bone Spine 2022 Apr 28;89(5):105384. Epub 2022 Apr 28.

Neurosurgery department, Sainte-Anne Military Teaching Hospital, 2, boulevard Sainte-Anne, 83800 Toulon cedex 9, France; École du Val-de-Grâce, French Military Health Service Academy, 1, place Alphonse-Laveran, 75230 Paris cedex 5, France. Electronic address:

Eur J Vasc Endovasc Surg 2022 Apr 25. Epub 2022 Apr 25.

Vascular Surgery Department, Ludwig Maximilian University Hospital, Munich, Germany.

Objective: Perform a systematic review and meta-analysis of the outcomes of physician modified endografts (PMEG) for treatment of thoraco-abdominal (TAAA) and complex abdominal aortic aneurysm (C-AAA) repair.

Methods: We searched MEDLINE, CENTRAL, Web of Science Core Collection, Scielo and Open Grey databases from inception to July 2021 for studies reporting on outcomes of PMEGs for TAAA or C-AAA repair. A systematic review was conducted (protocol CRD42021267856) and data were pooled using a random-effects model of proportions. Read More

J Affect Disord 2022 07 14;309:141-150. Epub 2022 Apr 14.

Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Department of Psychiatry, Medical University of Plovdiv, Plovdiv, Bulgaria; IMPACT Strategic Research Center, Deakin University, Geelong, Australia.

Objectives: To delineate the effects of white matter hyperintensities (WMHs) as measured by Fluid-attenuated inversion recovery (FLAIR) and infarction volume as measured by Diffusion-weighted imaging (DWI) on post-stroke depression symptoms.

Methods: Baseline National Institutes of Health Stroke Score (NIHSS) and Modified Rankin Scale (mRS) scores, and FLAIR and DWI MRIs to assess WMHs and acute infarct volumes, respectively, were assessed in 47 patients (≥55 years) with acute ischemic stroke and 17 normal controls. The Montgomery-Åsberg Depression Rating Scale (MDRS) was assessed three months after the stroke. Read More

Neurohospitalist 2022 Apr 10;12(2):318-322. Epub 2022 Feb 10.

Division of Neurology, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.

We present the case of a 73-year-old woman with a 3-month history of non-traumatic thoracic myelopathy. Initial MRI showed a T6-conus T2 signal hyperintensity. Based on this presentation, and given a personal and family history of autoimmune disease, our patient was first managed as an inflammatory transverse myelitis. Read More

Cells 2022 04 2;11(7). Epub 2022 Apr 2.

Department of Orthopaedic Surgery, Tohoku Medical and Pharmaceutical University, Sendai 983-8536, Japan.

Autophagy is an important function that mediates the degradation of intracellular proteins and organelles. Chaperone-mediated autophagy (CMA) degrades selected proteins and has a crucial role in cellular proteostasis under various physiological and pathological conditions. CMA dysfunction leads to the accumulation of toxic protein aggregates in the central nervous system (CNS) and is involved in the pathogenic process of neurodegenerative diseases, including Parkinson's disease and Alzheimer's disease. Read More

Ann Med Surg (Lond) 2022 Mar 5;75:103344. Epub 2022 Feb 5.

Departement of Neurosurgery, Medical Faculty of Mataram University, West Nusa Tenggara General Hospital, Mataram, Indonesia.

Background: Damaged neural tissue caused by SCI could induce vascular endothelial growth factor (VEGF) that can worsen the condition in the late phase by increasing vascular permeability, thus inducing tissue oedema, which can worsen the infarction. MLC 901 has been widely used in Asia for stroke patients because its mechanism is known to down-regulate VEGF levels in ischemic tissue.

Methods: Ten Sprague-Dawley rats were used in this experiment. Read More

Comput Math Methods Med 2022 23;2022:3812509. Epub 2022 Mar 23.

Department of Neurology, Shandong Provincial Third Hospital, Shandong University, Jinan, 250031 Shandong, China.

White matter hyperintensities (WMH), also known as white matter osteoporosis, have been clinically proven to be associated with cognitive decline, the risk of cerebral infarction, and dementia. The existing computer automatic measurement technology for the segmentation of patients' WMH does not have a good visualization and quantitative analysis. In this work, the author proposed a new WMH quantitative analysis and 3D reconstruction method for 3D reconstruction of high signal in white matter. Read More

Case Rep Neurol 2022 Jan-Apr;14(1):31-37. Epub 2022 Feb 7.

Department of Radiology, Vaasa Central Hospital, Vaasa, Finland.

When used appropriately, buprenorphine and oxycodone are safe drugs. They are, however, widely abused in combination with other drugs. Here we describe a case series of 8 patients with cervical myelopathy and rhabdomyolysis of the adjacent deep neck muscles after using an opioid in combination with other drugs. Read More

Perm J 2021 06 9;25. Epub 2021 Jun 9.

California Northstate University College of Medicine, Elk Grove, CA.

Background: Spontaneous spinal cord infarctions are rare, especially in the conus medullaris (CM). They are a particularly uncommon presentation in patients with familial Mediterranean fever (FMF).

Case Description: Our patient is a 50-year-old man with FMF, controlled with colchicine for 20 years, who presented to the emergency department when he developed the inability to ambulate without assistance. Read More

J Cardiothorac Vasc Anesth 2022 Feb 12. Epub 2022 Feb 12.

Department of Anesthesiology at the Wexner Medical Center at the Ohio State University in Columbus, Columbus, OH.

Spinal Cord Ser Cases 2022 03 21;8(1):33. Epub 2022 Mar 21.

National Spinal Injuries Centre, Stoke Mandeville Hospital, Aylesbury, UK.

Introduction: Spinal cord injury is a devastating complication, though rare but possible following the intramuscular injection of the Penicillin. The spinal cord injury can be permanent, leaving the patient with paralysis, bowel and bladder incontinence, and with other associated morbidities.

Case Presentation: We report a 25-year-old gentleman who developed anterior spinal cord syndrome following the benzathine benzylpenicillin injection. Read More

Ther Adv Neurol Disord 2022 11;15:17562864221076321. Epub 2022 Mar 11.

Department of Neurology, Landesklinikum Mistelbach-Gänserndorf, Liechtensteinstr. 67, 2130 Mistelbach, Austria.

Background: Spinal cord infarction (SCI) is a neurological emergency associated with high rates of persistent neurological deficits. Knowledge about this rare but potentially treatable condition needs to be expanded.

Objective: To describe the characteristics of spontaneous SCI in a large retrospective series of patients treated at two tertiary care centers in Austria. Read More

Cureus 2022 Feb 4;14(2):e21916. Epub 2022 Feb 4.

Department of Neurosurgery and Neuroendovascular Therapy Center, Soseikai General Hospital, Kyoto, JPN.

Endovascular trapping of vertebral artery dissecting aneurysm (VADA) can lead to ischemic complications, including medullary infarction due to obstruction of perforating arteries, and cervical spinal cord infarction caused by ischemia of spinal arteries branching from the affected vertebral artery (VA). This report describes a rare case of concomitant medullary and spinal cord infarction following internal trapping of ruptured VADA. A 47-year-old male presented with severe subarachnoid hemorrhage and neurological pulmonary edema, and a vertebral angiogram demonstrated VADA. Read More

BMJ Case Rep 2022 Mar 9;15(3). Epub 2022 Mar 9.

Hemoptysis and Pulmonary-Circulation Center, Eishinkai Kishiwada Rehabilitation Hospital, Kishiwada, Osaka, Japan.

A 41-year-old woman presented with spinal cord infarction and paraplegia after acute thoracoabdominal aortic dissection. Clinical evaluation revealed the American Spinal Injury Association (ASIA) lower limb exercise score of 0 points and the Functional Assessment for Control of Trunk (FACT) score of 0 points. Conventional physical therapy for 60 days did not significantly improve the paraplegia or FACT score; therefore, belt electrode skeletal muscle electrical stimulation (B-SES) and virtual reality (VR)-guided sitting balance training were introduced for 30 days. Read More

Asia Pac J Ophthalmol (Phila) 2022 Mar-Apr 01;11(2):168-176. Epub 2022 Feb 23.

Department of Neurology, Mayo Clinic College of Medicine and Science, Scottsdale, AZ, US.

Abstract: Transient ischemic attack (TIA) is defined as a transient episode of neurological dysfunction resulting from focal brain, spinal cord, or retinal ischemia, without associated infarction. Consequently, a TIA encompasses amaurosis fugax (AF) that is a term used to denote momentary visual loss from transient retinal ischemia. In this review, we use the word TIA to refer to both cerebral TIAs (occurring in the brain) and AF (occurring in the retina). Read More

ACS Chem Neurosci 2022 03 14;13(5):688-699. Epub 2022 Feb 14.

Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon 97239, United States.

Chondroitin sulfate proteoglycans (CSPGs) prevent sympathetic nerve regeneration in the heart after myocardial infarction and prevent central nerve regrowth after traumatic brain injury and spinal cord injury. Currently, there are no small-molecule therapeutics to promote nerve regeneration through CSPG-containing scars. CSPGs bind to monomers of receptor protein tyrosine phosphatase sigma (PTPσ) on the surface of neurons, enhancing the ability of PTPσ to bind and dephosphorylate tropomyosin receptor kinases (Trks), inhibiting their activity and preventing axon outgrowth. Read More

J Cardiovasc Surg (Torino) 2022 Jun 10;63(3):317-327. Epub 2022 Feb 10.

Department of Thoracic and Vascular Surgery, Ghent University Hospital, Ghent, Belgium.

Background: Endovascular aortic aneurysm repair (EVAR) has become the most popular technique to treat infrarenal abdominal aortic aneurysms. In aneurysms with unsuitable anatomy open surgical repair remains the golden standard but fenestrated EVAR (FEVAR) or branched EVAR (BEVAR) may be an alternative to treat juxtarenal or thoracoabdominal aneurysms. The aim of this study was to report our results and to evaluate its safety and feasibility. Read More

N Am Spine Soc J 2021 Dec 28;8:100080. Epub 2021 Sep 28.

Carle Illinois College of Medicine, University of Illinois Urbana Champaign, Champaign, IL, 61820, USA.

Background: We seek to characterize the features of iatrogenic spinal ischemia, determine which spinal levels are affected, and evaluate the efficacy of management strategies.

Methods: We performed a meta-analysis of case reports and series of spinal ischemia in the past 10 years. 343 full-length case reports and case series were screened against predefined inclusion/exclusion criteria. Read More

Neuroimage Clin 2022 4;33:102953. Epub 2022 Feb 4.

Department of Neurology, University Hospital, LMU Munich, Germany; German Centre for Vertigo and Balance Disorders (DSGZ), University Hospital, LMU Munich, Germany; Munich Centre of Neuroscience, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.

Objective: The integration of somatosensory, ocular motor and vestibular signals is necessary for self-location in space and goal-directed action. We aimed to detect remote changes in the cerebral cortex after thalamic infarcts to reveal the thalamo-cortical connections necessary for multisensory processing and ocular motor control.

Methods: Thirteen patients with unilateral ischemic thalamic infarcts presenting with vestibular, somatosensory, and ocular motor symptoms were examined longitudinally in the acute phase and after six months. Read More