11,434 results match your criteria Spina Bifida


Interrater Reliability of the Pediatric Neuromuscular Recovery Scale in Children with Spina Bifida.

Dev Neurorehabil 2019 Apr 23:1-6. Epub 2019 Apr 23.

a University of St. Augustine for Health Sciences , Austin , TX , USA.

Purpose: The purpose of this study was to examine the interrater reliability of the Pediatric Neuromuscular Recovery Scale (Peds NRS) to classify motor capacity in children with myelomeningocele (MMC) form of spina bifida.

Methods: Twenty-one children with MMC (1.5-10 years of age) were each scored on the Peds NRS three times: two live testing sessions and one video recorded session. Read More

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http://dx.doi.org/10.1080/17518423.2019.1604581DOI Listing

"If Everyone Else Is Having This Talk With Their Doctor, Why Am I Not Having This Talk With Mine?": The Experiences of Sexuality and Sexual Health Education of Young Women With Spina Bifida.

J Sex Med 2019 Apr 19. Epub 2019 Apr 19.

University of Michigan, Department of Urology, Ann Arbor, MI, USA; University of Michigan, Department of Urology, Dow Division of Health Services Research, Ann Arbor, MI, USA.

Introduction: Women with spina bifida are sexually active, but most never discuss this topic with providers.

Aim: To determine what women with spina bifida understand about their sexual health, how they learned about it, what questions they have, and their experiences with their sexuality.

Methods: For this qualitative study, women with spina bifida ages 16 and older without marked developmental delay were individually interviewed. Read More

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http://dx.doi.org/10.1016/j.jsxm.2019.03.012DOI Listing

Maternal periconceptional body mass index and risk for neural tube defects: results from a large cohort study in China.

J Matern Fetal Neonatal Med 2019 Apr 22:1-7. Epub 2019 Apr 22.

a Institute of Reproductive and Child Health , Peking University/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China , Beijing , P. R. China.

Background: Case-control studies have consistently suggested an association between pre- or periconceptional maternal obesity and an increased risk for neural tube defects (NTDs). Few studies have examined the association between body mass index (BMI) and NTDs using measured weight and height. We examined this association in a large cohort study in China. Read More

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http://dx.doi.org/10.1080/14767058.2019.1606192DOI Listing

Dorsal Spinal Intradural Intramedullary Epidermoid Cyst: A Rare Case Report and Review of Literature.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):352-354

Department of Pathology, Osmania Medical College, Hyderabad, Telangana, India.

Epidermoid cysts are commonly seen intracranial lesions but their occurrence in the spine is rare. They account for <1% of all the benign tumors of the spine. These are benign epithelial-lined cysts filled with keratin. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_304_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454963PMC

Applicability of histopathological osteomyelitis evaluation score (HOES) in chronic osteomyelitis of the foot - A feasibility study.

Foot Ankle Surg 2019 Apr 2. Epub 2019 Apr 2.

Dept. of Orthopaedics, Sri Sathya Sai Institute of Higher Medical Sciences - Prasanthigram, Puttaparthi, Andhra Pradesh, 515134 India. Electronic address:

Background: Diagnosis and classification of chronic osteomyelitis is not based on any objective criteria. None of the available methods for this is completely reliable. Tienmann et al. Read More

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http://dx.doi.org/10.1016/j.fas.2019.03.008DOI Listing

Cutaneous markers of occult spinal dysraphism.

Pediatr Neonatol 2019 Mar 27. Epub 2019 Mar 27.

Department of Paediatrics, Hospital Garcia de Orta, EPE, Almada, Portugal.

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https://linkinghub.elsevier.com/retrieve/pii/S18759572183071
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http://dx.doi.org/10.1016/j.pedneo.2019.03.010DOI Listing
March 2019
1 Read

A case-control analysis of maternal diet and risk of neural tube defects in Bangladesh.

Birth Defects Res 2019 Apr 15. Epub 2019 Apr 15.

Department of Neurology, Boston Children's Hospital, Boston, Massachusetts.

Objectives: Mothers need a nutrient-rich diet for healthy neural tube development. Neural tube defect risk can be reduced through fortifying grain products with folic acid and taking folic acid supplements. Fortification is not required in Bangladesh. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/bdr2.1505
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http://dx.doi.org/10.1002/bdr2.1505DOI Listing
April 2019
2 Reads

Cystoscopically Guided Repair of a Posterior Perforation of Augmented Bladder.

J Endourol Case Rep 2019 18;5(1):22-24. Epub 2019 Mar 18.

Department of Urology, San Antonio Military Medical Center, San Antonio, Texas.

Augmentation cystoplasty for the management of neurogenic bladder is one of the mainstays of pediatric urology. This procedure has multiple well-known complications. The most dangerous of these complications is bladder perforation, which has a mortality rate of 23% to 25% in large part caused by delayed presentation and sepsis. Read More

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https://www.liebertpub.com/doi/10.1089/cren.2018.0065
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http://dx.doi.org/10.1089/cren.2018.0065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461056PMC
March 2019
2 Reads

Camp-based psychosocial intervention dosage and changes in independence in young people with spina bifida.

Dev Med Child Neurol 2019 Apr 13. Epub 2019 Apr 13.

Psychology Department, Loyola University Chicago, Chicago, IL, USA.

Aim: To examine associations between camp-based intervention dosage and changes in independence-related skills for young people with spina bifida.

Method: Participants were 110 individuals (mean age [SD] 14y 7mo [6y 1mo], range 6-32y; 66 females, 54 males) who attended a summer camp for individuals with spina bifida between 2 to 6 times (mean 2.40; operationalized as 'dosage'). Read More

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http://dx.doi.org/10.1111/dmcn.14250DOI Listing

Health behaviors and disordered eating in adolescents and young adults with spina bifida: results from a national survey.

Disabil Rehabil 2019 Apr 12:1-7. Epub 2019 Apr 12.

a Department of Psychology , Loyola University Chicago , Chicago , IL , USA.

Purpose: Youth with disabilities are at higher risk for obesity, disordered eating, and poor body image but are often excluded from research on these domains. The current study is the first to characterize health behaviors, body mass index, and disordered eating cognitions and behaviors in a national sample of adolescent and young adult males and females with spina bifida.

Methods: Participants were recruited nationally through the support of a national spina bifida-related organization to complete an anonymous survey assessing health behaviors and disordered eating. Read More

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http://dx.doi.org/10.1080/09638288.2019.1575483DOI Listing
April 2019
1 Read

Crash sign: a new first-trimester sonographic marker of spina bifida.

Ultrasound Obstet Gynecol 2019 Apr 11. Epub 2019 Apr 11.

Fetal Medicine Unit, Elizabeth Garrett Anderson Wing, University College London Hospital, 235 Euston Road, London, NW1 2BU.

Objectives: To describe a new first trimester sonographic sign associated with open fetal spina bifida ("crash sign") where there is posterior displacement and deformation of the mesencephalon against the occipital bone in the axial view, and to evaluate its clinical usefulness in the first trimester diagnosis of spina bifida.

Methods: This was a retrospective review of patients referred to three fetal medicine centres in the first trimester (11-13+6 weeks) with suspected spina bifida. Spina bifida was confirmed by direct visualisation of the spinal defect by two experts and, where possible, examined at fetal post-mortem. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/uog.20285
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http://dx.doi.org/10.1002/uog.20285DOI Listing
April 2019
7 Reads
3.853 Impact Factor

Spinal Angulation: A Limitation of the Fetal Lamb Model of Myelomeningocele.

Fetal Diagn Ther 2019 Apr 10:1-9. Epub 2019 Apr 10.

Department of Surgery, University of California Davis, Sacramento, California, USA.

Introduction: The surgically induced fetal lamb model is the most commonly used large animal model of myelomeningocele (MMC) but is subject to variation due to surgical technique during defect creation.

Material And Methods: Thirty-one fetal lambs underwent creation of the MMC defect, followed by defect repair with either an extracellular matrix (ECM) patch (n = 10) or ECM seeded with placental mesenchymal stromal cells (n = 21). Postnatal hindlimb function was assessed using the Sheep Locomotor Rating (SLR) scale. Read More

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http://dx.doi.org/10.1159/000496201DOI Listing
April 2019
2 Reads

LONG-TERM OUTCOME OF RENAL TRANSPLANTATION IN PATIENTS WITH CONGENITAL LOWER URINARY TRACT MALFORMATIONS: A MULTICENTER STUDY.

Transplantation 2019 Apr 4. Epub 2019 Apr 4.

Urology and renal transplantation, Montpellier University hospital, France.

Introduction: Renal insufficiency can occur in patients with congenital lower urinary tract malformations (LUTM) even when managed during infancy. Data in the current literature concerning this subject remain sparse. The aim of this study was to report the feasibility and long-term results of renal transplantation during adulthood in patients with a congenital LUTM. Read More

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http://dx.doi.org/10.1097/TP.0000000000002746DOI Listing
April 2019
1 Read

Cervical intradural extramedullary epidermoid cyst at the background of congenital scoliosis with a semi-segmented C6 hemivertebra.

Childs Nerv Syst 2019 Apr 5. Epub 2019 Apr 5.

School of Medicine, Department of Physical Medicine and Rehabilitation, Bahçeşehir University, Istanbul, Turkey.

In the present case study, we present a female adolescent patient harboring a rare clinical presentation of spinal intradural extramedullary epidermoid cyst concomitant with congenital scoliosis. A 17-year-old female patient was admitted to the clinic with long-lasting neck pain. She was neurologically intact yet had cervicothoracic scoliosis. Read More

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http://dx.doi.org/10.1007/s00381-019-04144-wDOI Listing

[Preoperative Diagnosis of Spinal Immature Teratoma Associated with Cerebrospinal Fluid Leakage from the Congenital Dermal Sinus Tract in a 0-Day-Old Infant:A Case Report].

No Shinkei Geka 2019 Mar;47(3):337-342

Department of Neurosurgery, Iwate Medical University School of Medicine.

We report the case of a patient with spinal immature teratoma and cerebrospinal fluid leakage from the congenital dermal sinus tract. A 0-day-old female infant presented with a subcutaneous soft mass with a dimple in the lumbosacral region at birth. Magnetic resonance imaging revealed a mixed low-intensity mass located in the extraspinal and intraspinal canal with a sinus tract. Read More

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http://dx.doi.org/10.11477/mf.1436203940DOI Listing

Human Tail: A Benign Condition Hidden Out of Social Stigma and Shame in Young Adult - A Case Report and Review.

Asian J Neurosurg 2019 Jan-Mar;14(1):1-4

Department of Neurosurgery, Super Speciality Hospital and Government Medical College, Nagpur, Maharashtra, India.

A human tail is a rare congenital anomaly which mostly presents immediately after birth or in early childhood. Here, we are presenting a case of 17-year-old male who presented with 18-cm long tail, which was hidden till this age because of social stigma and shame. This is longest human tail reported of our knowledge. Read More

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http://www.asianjns.org/text.asp?2019/14/1/1/231028
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http://dx.doi.org/10.4103/ajns.AJNS_209_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417348PMC
April 2019
13 Reads

Atypical presentation of currarino syndrome: A case report.

Int J Surg Case Rep 2019 Mar 18;57:102-105. Epub 2019 Mar 18.

Department of Pediatric Surgery, Saint George Hospital University Medical Center, Balamand University, Beirut, Lebanon.

Introduction: Currarino syndrome is a rare congenital disorder characterized by a triad of anorectal malformation, a sacral bone defect, and a presacral mass. It results of an abnormal separation of the ectoderm from the endoderm caused by HLXB9 mutation in chromosome 7q36 in 50% of cases. The disorder is mostly hereditary as it can also be sporadic with a variable expression spectrum. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.02.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441767PMC
March 2019
1 Read

Correlation Between Neurologic Impairment Grade and Ambulation Status in the Adult Spina Bifida Population.

Am J Phys Med Rehabil 2019 Mar 29. Epub 2019 Mar 29.

Department of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, PA.

Objective: This study's purpose was to identify which neurologic impairment scales correlate with ambulation status in adults with spina bifida.

Design: A retrospective chart review was performed on patients seen at the UPMC Adult Spina Bifida Clinic. Findings were graded using several neurologic impairment scales: two versions of the National Spina Bifida Patient Registry (NSBPR) classification, the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) motor level, and the Broughton Neurologic Impairment Scale. Read More

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http://dx.doi.org/10.1097/PHM.0000000000001188DOI Listing

Awareness of risk factors and preventive measures for neural tube defects and the Saudi population perception towards pregnancy termination as a possible option.

J Neonatal Perinatal Med 2019 Mar 29. Epub 2019 Mar 29.

College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, National Guard Hospital, Jeddah, Saudi Arabia.

Background: Neural tube defects (NTDs) are among the most common congenital anomalies worldwide with an incidence of 300,000/year. Spina bifida, which is the most prevalent NTD, has an incidence of 1.2/1000 live births in Saudi Arabia. Read More

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http://dx.doi.org/10.3233/NPM-17165DOI Listing
March 2019
2 Reads

Prevalence of selected birth defects by maternal nativity status, United States, 1999-2007.

Birth Defects Res 2019 Mar 28. Epub 2019 Mar 28.

Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, Texas.

Objectives: We investigated differences in prevalence of major birth defects by maternal nativity within racial/ethnic groups for 27 major birth defects.

Methods: Data from 11 population-based birth defects surveillance systems in the United States including almost 13 million live births (approximately a third of U.S. Read More

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http://dx.doi.org/10.1002/bdr2.1489DOI Listing
March 2019
1 Read

Association of maternal risk factors with the recent rise of neural tube defects in Canada.

Paediatr Perinat Epidemiol 2019 03;33(2):145-153

Department of Obstetrics and Gynaecology and the School of Population and Public Health, University of British Columbia and the Children's and Women's Hospital of British Columbia, Vancouver, British Columbia, Canada.

Background: We sought to assess the recent trend in NTD prevalence at birth in the post-folic acid food fortification era and to identify the maternal risk factors associated with that trend.

Methods: We carried out a population-based study of all livebirths and stillbirths (including late pregnancy terminations) delivered in hospitals in Canada (excluding Quebec) from 2004 to 2015 (n = 3 439 330). We examined NTD birth prevalence by year, multiple pregnancy, maternal age, parity, pregestational diabetes, chronic illness, and problematic substance use. Read More

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http://dx.doi.org/10.1111/ppe.12543DOI Listing
March 2019
1 Read

Randomized Clinical Trial Using Sterile Single Use and Reused Polyvinylchloride Catheters for Intermittent Catheterization with a Clean Technique in Spina Bifida: Short-Term Urinary Tract Infection Outcomes.

J Urol 2019 Mar 27:101097JU0000000000000244. Epub 2019 Mar 27.

Urology Residency Program, Universidad Autónoma de Nuevo León , Monterrey , Mexico.

Purpose: Urinary tract infections are common and severe complications in patients with spina bifida. Management includes intermittent bladder catheterization with single use or reused sterile catheters. There is insufficient evidence to set a standard among the different techniques. Read More

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http://dx.doi.org/10.1097/JU.0000000000000244DOI Listing
March 2019
1 Read

Low level myelomeningoceles: do they need prenatal surgery?

Childs Nerv Syst 2019 Mar 27. Epub 2019 Mar 27.

Department of Pediatric Neurosurgery, Hôpital Femme Mère Enfant, 32 Avenue du Doyen Jean Lépine, 69677, Lyon Cedex, France.

Background: Postnatal closure of a myelomeningocele remains the standard of care in many countries. The prenatal closure has given hope for decreasing the damage to the neural placode and has challenged classic management. However, this technique presents potential sources of complications. Read More

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http://dx.doi.org/10.1007/s00381-019-04123-1DOI Listing
March 2019
1 Read

Commentary on "Cardiopulmonary Exercise Test Using Arm Ergometry in Children With Spina Bifida: A Prediction Model for O2peak.

Pediatr Phys Ther 2019 04;31(2):191

Netherlands Institute for Healthcare Services Research (NIVEL) and HU University of Applied Sciences Utrecht, the Netherlands De Hoogstraat Rehabilitation and HU University of Applied Sciences Utrecht, the Netherlands.

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http://dx.doi.org/10.1097/PEP.0000000000000600DOI Listing
April 2019
2 Reads

Cardiopulmonary Exercise Test Using Arm Ergometry in Children With Spina Bifida: A Prediction Model for O2peak.

Pediatr Phys Ther 2019 04;31(2):185-190

Department of Physiology (Ms Tuijtelaars), Radboud Universiteit, Nijmegen, the Netherlands; Departments of Health Sciences (Ms Leonardi-Figuiredo and Dr Mattiello-Sverzut), Cardiology (Drs Crescencio and Gallo), and Social Medicine (Dr Martinez), Ribeirão Preto Medical School, University of Sao Paulo, Sao Paulo, SP, Brazil; Child Development & Exercise Center (Drs Bloemen and Takken), Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands; Research Group Lifestyle and Health (Dr Bloemen) and Master Program Pediatric Physical Therapy (Dr Bloemen), HU University of Applied Sciences Utrecht, Utrecht, the Netherlands.

Purpose: This study aimed to develop a prediction model for peak oxygen uptake ((Equation is included in full-text article.)O2peak) in children with spina bifida (SB), considering peak workload (Wpeak), peak heart rate, age, sex, anthropometric measures, walking level, physical activity level, and level of the lesion.

Methods: Data of 26 participants with SB performing a graded arm crank test were used to develop the prediction model. Read More

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http://dx.doi.org/10.1097/PEP.0000000000000590DOI Listing
April 2019
1 Read

Outcomes of Intradetrusor OnabotulinumtoxinA Injection in Adults with Congenital Spinal Dysraphism in Tertiary Transitional Urology Clinic.

Urol Pract 2019 Mar 4;6(2):112-116. Epub 2018 Jul 4.

Department of Urology, Houston Methodist Hospital, Houston, TX.

Purpose: Published data regarding intradetrusor injection of onabotulinumtoxinA in adults with congenital spinal dysraphism are scarce. In this study, we retrospectively investigated the outcomes of intradetrusor injection of onabotulinumtoxinA in this setting.

Materials And Methods: Billing codes were used to identify 149 patients who underwent onabotulinumtoxinA injection between 2012-2016 at our tertiary transitional urology clinic. Read More

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http://dx.doi.org/10.1016/j.urpr.2018.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428434PMC

Spina bifida in pregnancy: A review of the evidence for preconception, antenatal, intrapartum and postpartum care.

Obstet Med 2019 Mar 17;12(1):14-21. Epub 2018 May 17.

Department of Obstetrics, Maternal and Fetal Medicine, St Thomas' Hospital, London, UK.

Women with spina bifida in pregnancy require complex multi-disciplinary management. Most women have uncomplicated pregnancies; however, complications are more frequent than in 'low risk' pregnancies. Careful antenatal planning and management of the complications can optimise outcome. Read More

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http://journals.sagepub.com/doi/10.1177/1753495X18769221
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http://dx.doi.org/10.1177/1753495X18769221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416695PMC
March 2019
14 Reads

Subsequent Pregnancy Outcomes After Open Maternal-Fetal Surgery for Myelomeningocele.

Am J Obstet Gynecol 2019 Mar 15. Epub 2019 Mar 15.

Colorado Fetal Care Center, Denver, CO.

Background: Open maternal-fetal surgery (OMFS) for fetal myelomeningocele (fMMC) results in reduction in neonatal morbidity related to spina bifida but may be associated with fetal, neonatal, and maternal complications in subsequent pregnancies.

Objective: The objective of this study was to ascertain obstetric risk in subsequent pregnancies after OMFS for fMMC closure.

Study Design: An international multicenter prospective observational registry created to track and report maternal, obstetric, fetal/neonatal and subsequent pregnancy outcomes following OMFS for fMMC, was evaluated for subsequent pregnancy outcome variables. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029378193048
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http://dx.doi.org/10.1016/j.ajog.2019.03.008DOI Listing
March 2019
9 Reads

A de novo mutation in DHD domain of SKI causing spina bifida with no craniofacial malformation or intellectual disability.

Am J Med Genet A 2019 Mar 18. Epub 2019 Mar 18.

Department of orthopaedic Surgery, Spine Center, Changzheng Hospital, Second Military Medical Univerisity, Shanghai 20003, People's Republic of China.

Shprintzen-Goldberg syndrome (SGS) is a rare systemic connective tissue disorder characterized by craniofacial, skeletal, and cardiovascular manifestations. It is associated with a significant risk of intellectual disability, a feature which distinguishes it from Marfan and Loeys-Dietz syndromes. SGS is mainly caused by mutations in the SKI gene, a repressor of TGF-β activity. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ajmg.a.61088
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http://dx.doi.org/10.1002/ajmg.a.61088DOI Listing
March 2019
3 Reads
2.159 Impact Factor

Role of Neurocognitive Factors in Academic Fluency for Children and Adults With Spina Bifida Myelomeningocele.

J Int Neuropsychol Soc 2019 Mar;25(3):249-265

3Program in Neuroscience and Mental Health,The Hospital for Sick Children,Toronto,Canada.

Objectives: Fluency is a major problem for individuals with neurodevelopmental disorders, including fluency deficits for academic skills. The aim of this study was to determine neurocognitive predictors of academic fluency within and across domains of reading, writing, and math, in children and adults, with and without spina bifida. In addition to group differences, we expected some neurocognitive predictors (reaction time, inattention) to have similar effects for each academic fluency outcome, and others (dexterity, vocabulary, nonverbal reasoning) to have differential effects across outcomes. Read More

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https://www.cambridge.org/core/product/identifier/S135561771
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http://dx.doi.org/10.1017/S1355617718001200DOI Listing
March 2019
9 Reads

Sacral neuromodulation in congenital lumbo-sacral and traumatic spinal cord defects with neurogenic lower urinary tract symptoms: a single-center experience in children and adolescents.

World J Urol 2019 Mar 12. Epub 2019 Mar 12.

Shahid Labbafinejad Medical Center, Urology Nephrology Research Center, Shahid Beheshti University of Medical Sciences, No. 103, Boostan 9th St, Pasdaran Ave, Tehran, 1666663111, Iran.

Purpose: This study evaluated sacral neuromodulation's effectiveness for managing refractory neuropathic lower urinary tract dysfunction in children and adolescents.

Methods: Twenty-five children and adolescents underwent peripheral nerve evaluation test phase of sacral neuromodulation at our center. Thirteen (seven boys and six girls) cases suffered from neuropathic lower urinary tract dysfunction refractory to the maximum medical treatment. Read More

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http://dx.doi.org/10.1007/s00345-019-02721-xDOI Listing
March 2019
2 Reads

Examination of the prescription of antiepileptic drugs to prenatal and postpartum women in Japan from a health administrative database.

Pharmacoepidemiol Drug Saf 2019 Mar 10. Epub 2019 Mar 10.

Laboratory of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.

Purpose: To evaluate the prevalence and patterns of prescriptions of antiepileptic drugs (AEDs) to prenatal and postpartum women in Japan using a large administrative database.

Methods: The dates of pregnancy onset and delivery were estimated using published algorithms and infant birth months. The prevalence of prescribed AEDs, the maximum dose of some AEDs, and the frequency of potential combination therapy with AEDs were evaluated for the 180 days before pregnancy onset, during pregnancy, and at 180-day postpartum. Read More

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http://doi.wiley.com/10.1002/pds.4749
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http://dx.doi.org/10.1002/pds.4749DOI Listing
March 2019
4 Reads

Vitamin B-12 and liver activity and expression of methionine synthase are decreased in fetuses with neural tube defects.

Am J Clin Nutr 2019 Mar 6. Epub 2019 Mar 6.

Inserm UMRS 954, Nutrition-Genetics-Environmental Risk Exposure, Inserm and University of Lorraine, Nancy, France.

Background: The risk of neural tube defects (NTDs) is influenced by nutritional factors and genetic determinants of one-carbon metabolism. A key pathway of this metabolism is the vitamin B-12- and folate-dependent remethylation of homocysteine, which depends on methionine synthase (MS, encoded by MTR), methionine synthase reductase, and methylenetetrahydrofolate reductase. Methionine, the product of this pathway, is the direct precursor of S-adenosylmethionine (SAM), the universal methyl donor needed for epigenetic mechanisms. Read More

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http://dx.doi.org/10.1093/ajcn/nqy340DOI Listing
March 2019
4 Reads

Ectopic immature renal tissue presenting as a pedunculated sacral mass in a neonate.

Pediatr Dermatol 2019 Mar 6. Epub 2019 Mar 6.

University of Toronto, Toronto, Ontario.

Ectopic immature renal tissue (EIRT) has been reported in a variety of tissues of mesodermal origin, including the dermis of the skin. We report a case of a newborn with a congenital lumbosacral mass with pathologic findings consistent with EIRT. This report highlights the clinical and pathologic considerations of EIRT, including associations with spinal dysraphism, teratoma, and Wilm's tumor. Read More

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http://dx.doi.org/10.1111/pde.13809DOI Listing

Children and Teens in Charge of their Health (CATCH): A protocol for a feasibility randomised controlled trial of solution-focused coaching to foster healthy lifestyles in childhood disability.

BMJ Open 2019 Mar 4;9(3):e025119. Epub 2019 Mar 4.

Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada.

Introduction: Children with physical disabilities are rarely included in interventions to promote healthy lifestyles, despite being at higher risk for suboptimal dietary and physical activity behaviours. The Children and Teens in Charge of their Health study explores the feasibility and acceptability of conducting a randomised controlled trial (RCT) of a strengths-based, solution-focused coaching intervention for improving and sustaining physical activity and healthy dietary habits in children and young people with physical disabilities.

Methods And Analysis: Thirty children aged 10-18 years with a diagnosis of spina bifida or cerebral palsy who are able to set healthy lifestyle goals will be recruited from two children's rehabilitation hospitals in Ontario, Canada. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02511
Publisher Site
http://dx.doi.org/10.1136/bmjopen-2018-025119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429893PMC
March 2019
10 Reads

Complex spinal dysraphism: myelomenigocele associated with dorsal bony spur, split cord malformation type I, syringomyelia, lipoma and tethered cord.

Br J Neurosurg 2019 Mar 5:1-3. Epub 2019 Mar 5.

a Govind Ballabh Pant Institute of Postgraduate Medical Education and Research (GIPMER) , Neurosurgery , New Delhi , India.

Variations in split cord malformation (SCM) are known. However, association of SCM type I with myelomeningocele along with same level dorsal bony spur has not been described previously. We report a 1-year old male child who presented with these findings with associated syringomyelia, lipoma and tethered cord. Read More

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http://dx.doi.org/10.1080/02688697.2019.1584660DOI Listing
March 2019
7 Reads
0.947 Impact Factor

Management of prenatally diagnosed spina bifida: how do we move ahead?

Authors:
M Bebbington

Ultrasound Obstet Gynecol 2019 03;53(3):287-289

The Fetal Care Center, Department of Obstetrics & Gynecology, Washington University in St Louis School of Medicine, 660 South Euclid Ave, Campus Box 8064-37-1005, St. Louis, MO, 63110, USA.

Linked Comment: Ultrasound Obstet Gynecol 2018; 53: 293-301 Linked Comment: Ultrasound Obstet Gynecol 2018; 53: 302-308 Linked Comment: Ultrasound Obstet Gynecol 2018; 53: 309-313. Read More

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http://dx.doi.org/10.1002/uog.20226DOI Listing
March 2019
1 Read

[Empyema in Left Ureteral Stump Following Bilateral Nephrectomy and Living Renal Transplant-Case Report].

Hinyokika Kiyo 2019 Jan;65(1):19-22

The Department of Urology, Hyogo Prefectural Nishinomiya Hospital.

A 34-year-old male came to us with congenital spina bifida, vesicoureteral reflux and scoliosis. He had been on hemodialysis for chronic renal failure caused by reflux nephropathy since the age of 23 years. At the age of 24, he received bilateral nephrectomy and underwent living renal transplantation from his mother. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_65_1_19DOI Listing
January 2019
2 Reads

Ben W. Lichtenstein (1908-2003) and his contributions to our knowledge of spinal dysraphism.

Childs Nerv Syst 2019 Mar 2. Epub 2019 Mar 2.

Department of Anatomical Sciences, St. George's University, St. George's, Grenada.

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http://dx.doi.org/10.1007/s00381-019-04106-2DOI Listing

Radiographic abnormalities, bladder interventions, and bladder surgery in the first decade of life in children with spina bifida.

Pediatr Nephrol 2019 Mar 3. Epub 2019 Mar 3.

Division of Pediatric Urology, Indiana University School of Medicine, 535 Barnhill Drive, Suite 150, Indianapolis, IN, 46202, USA.

Background: Spina bifida (SB) patients are at increased risk for hydronephrosis, bladder storage and emptying problems, and renal failure that may require multiple bladder surgeries.

Methods: We retrospectively reviewed patients born with SB 2005-2009, presenting to our institution within 1 year of birth. Outcomes at 8-11 years old included final renal/bladder ultrasound (RBUS) results, clean intermittent catheterization (CIC) use, anticholinergic use, surgical interventions, and final renal function. Read More

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http://dx.doi.org/10.1007/s00467-019-04222-wDOI Listing
March 2019
1 Read

[Long-term follow-up of continent cystostomy with the Mitrofanoff procedure: 5 years later].

Prog Urol 2019 Mar 26;29(3):147-155. Epub 2019 Feb 26.

Service d'urologie, CHU de Grenoble, BP 217, 38043 Grenoble cedex 9, France.

Introduction: This study analyzed long-term functional outcome of continent catheterizable channels with the Mitrofanoff procedure, their continence, complications and the satisfaction of the patients.

Material And Method: Data from patients who underwent a Mitrofanoff procedure at our institution from June 1997 to March 2015 were retrospectively collected. All patients were contacted at the end of the study, a survey was submitted to them. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S11667087183068
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http://dx.doi.org/10.1016/j.purol.2018.12.006DOI Listing
March 2019
8 Reads

Association of maternal chronic arsenic exposure with the risk of neural tube defects in Northern China.

Environ Int 2019 May 23;126:222-227. Epub 2019 Feb 23.

Institute of Reproductive and Child Health, Department of Epidemiology and Biostatistics, School of Public Health, Peking University/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Beijing 100191, PR China.

Numerous animal studies have shown that high arsenic exposure can induce neural tube defect (NTD) formation. However, epidemiological evidence related to this finding is scarce. The key objective of our study is to evaluate whether maternal arsenic exposure is associated with NTD risk in Northern China. Read More

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http://dx.doi.org/10.1016/j.envint.2019.02.016DOI Listing
May 2019
2 Reads

Scorecard for spina bifida research, prevention, and policy: Score analysis by Human Development Index and WHO region.

Prev Med 2019 Feb 11;123:1-7. Epub 2019 Feb 11.

March of Dimes Inc., USA.

The People and Organizations United for Spina Bifida and Hydrocephalus (PUSH!) Global Alliance created scorecards to rate country-level performance on spina bifida, including folate status among women of reproductive age; birth prevalence and mortality associated with spina bifida; prevention strategies; access to care; and the country's engagement in the UN Convention on the Rights of Persons with Disabilities. A total of 187 countries were examined based on a criteria-based scoring system represented by stars (http://www.pu-sh. Read More

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http://dx.doi.org/10.1016/j.ypmed.2019.02.020DOI Listing
February 2019
3 Reads

Application of quality indicators to data from the National Network of Congenital Anomalies of Argentina.

Birth Defects Res 2019 Apr 13;111(6):333-340. Epub 2019 Feb 13.

National Network of Congenital Anomalies of Argentina (RENAC), National Center of Medical Genetics, National Administration of Health Laboratories and Institutes, National Ministry of Health, Buenos Aires, Argentina.

Background: In Argentina, birth defects are a leading cause of infant deaths. In 2009, the National Network for Congenital Anomalies of Argentina (RENAC) was established as a hospital-based surveillance system of major structural birth defects. To assess and enhance the system's data quality, we previously developed data quality indicators (DQI). Read More

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http://dx.doi.org/10.1002/bdr2.1472DOI Listing
April 2019
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Neuroprotective effect of placenta-derived mesenchymal stromal cells: role of exosomes.

FASEB J 2019 Feb 12:fj201800972R. Epub 2019 Feb 12.

Surgical Bioengineering Laboratory, Department of Surgery, University of California-Davis, Sacramento, California, USA.

We have established early-gestation chorionic villus-derived placenta mesenchymal stromal cells (PMSCs) as a potential treatment for spina bifida (SB), a neural tube defect. Our preclinical studies demonstrated that PMSCs have the potential to cure hind limb paralysis in the fetal lamb model of SB via a paracrine mechanism. PMSCs exhibit neuroprotective function by increasing cell number and neurites, as shown by indirect coculture and direct addition of PMSC-conditioned media to the staurosporine-induced apoptotic human neuroblastoma cell line, SH-SY5Y. Read More

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http://dx.doi.org/10.1096/fj.201800972RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463921PMC
February 2019
3 Reads

Guidelines for Care of People with Spina Bifida.

J Pediatr Nurs 2019 Mar - Apr;45:81-82. Epub 2019 Feb 10.

Minnesota State University, Mankato, MN, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.pedn.2019.01.007DOI Listing
February 2019

Impact of neurological level and spinal curvature on pulmonary function in adults with spina bifida.

J Pediatr Rehabil Med 2018 ;11(4):243-254

Human Engineering Research Laboratories, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, USA.

Purpose: To describe pulmonary function and determine the impact of neurological level, scoliosis, and obesity on pulmonary function in people with spina bifida (SB).

Methods: Participants with SB (N= 29) (15 females; age, 30 ± 12 years) completed spirometry and body plethysmographic lung volume testing. Univariate and multivariate regression analyses were used to describe the factors associated with pulmonary function in people with SB. Read More

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http://dx.doi.org/10.3233/PRM-179451DOI Listing
January 2018
6 Reads

Dermoid sinus type VI associated with spina bifida and tethered cord syndrome in a French Bulldog.

J Vet Diagn Invest 2019 Mar 8;31(2):294-297. Epub 2019 Feb 8.

School of Veterinary Science, Massey University, Palmerston North, New Zealand.

A 4-mo-old French bulldog was presented with acute onset pain and reluctance to move. A tubular structure arising in the dorsal thoracic midline and extending from a cutaneous orifice into deeper tissues was palpated on physical examination. Computed tomography with sinography revealed a dermoid sinus associated with spina bifida at the level of T3-T4. Read More

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http://dx.doi.org/10.1177/1040638719827626DOI Listing