13,227 results match your criteria Spider Envenomation Redback
Proteomics 2018 Dec 5:e1800302. Epub 2018 Dec 5.
Department of Entomology, Nanjing Agricultural University, Nanjing, Jiangsu, 210095, China.
The spider mite Tetranychus evansi has a remarkable ability to suppress and manipulate plant defenses, which makes it an ideal model to investigate plant-herbivores interactions. In this study, we performed a de novo assembly of the transcriptome of T. evansi, and characterized the proteins in its secreted saliva by Liquid Chromatography-Mass Spectrometry/Mass Spectrometry (LC-MS/MS). Read More
PeerJ 2018 29;6:e6049. Epub 2018 Nov 29.
Department of Biogeography, Trier University, Trier, Germany.
The orb-weaver spider Simon 1922 (Araneae: Tetragnathidae) is one of the most common cave predators occurring in the Mediterranean basin. Although the congeneric represented the model species in several studies, our knowledge of is only founded on observations performed on a handful of populations. In this study spiders were studied in caves of Monte Albo (Sardinia, Italy) over a year. Read More
Proc Biol Sci 2018 Dec 5;285(1892). Epub 2018 Dec 5.
School of Earth Sciences, University of Bristol, Queen's Road, Bristol, UK
Colour vision is known to have arisen only twice-once in Vertebrata and once within the Ecdysozoa, in Arthropoda. However, the evolutionary history of ecdysozoan vision is unclear. At the molecular level, visual pigments, composed of a chromophore and a protein belonging to the opsin family, have different spectral sensitivities and these mediate colour vision. Read More
ACS Chem Biol 2018 Dec 3. Epub 2018 Dec 3.
Gating modifier toxins (GMTs) from spider venom can inhibit voltage gated sodium channels (NaVs) involved in pain signal transmission, including the NaV1.7 subtype. GMTs have a conserved amphipathic structure that allow them to interact with membranes and also with charged residues in regions of NaV that are exposed at the cell surface. Read More
J Dtsch Dermatol Ges 2018 Dec 3. Epub 2018 Dec 3.
Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany.
Eur J Neurosci 2018 Dec 1. Epub 2018 Dec 1.
Institute for Biomagnetism and Biosignal Analysis, University of Muenster, D-48149, Muenster, Germany.
Biased motivated attention towards phobia-relevant pictures is a typical finding in specific phobia. In the visual system, the allocation of motivated attention is indexed by two event-related potential components - the Early Posterior Negativity and the Late Positive Potential. Enhanced Early Posterior Negativity and Late Positive Potential amplitudes are reliably observed in specific phobia such as, for instance, snake, spider or blood-injection-injury phobia and to some extent also in dental phobia. Read More
Zookeys 2018 19(797):71-85. Epub 2018 Nov 19.
Zoological Museum, Center of Natural History, Universität Hamburg, Martin-Luther-King-Platz 3, 20146 Hamburg, Germany.
Three species from the family Oonopidae are newly described from leaf litter habitats in Sumatra, Indonesia based on male and female morphology. All three species belong to the genus Thoma, 2014: , , and Read More
Sex Med Rev 2018 Nov 28. Epub 2018 Nov 28.
Department of Urology, Tulane University, New Orleans, LA, USA. Electronic address:
Background: Priapism has been linked to many commonly prescribed medications, as well as recreational drugs and toxins. Although the incidence of priapism as a result of medication is small, the increasing use of antidepressants, antipsychotics, and recreational drugs may lead to more cases of pharmacologically-induced priapism in the future.
Aim: To provide a comprehensive, up-to-date review of the most common causes of pharmacologically induced priapism and discuss incidence, pathophysiology, and basic management strategies. Read More
Syst Biol 2018 Dec 4. Epub 2018 Dec 4.
Department of Entomology and Nematology, University of California Davis, 1 Shields Drive, Davis, CA, USA.
Instances of sexual size dimorphism (SSD) provide the context for rigorous tests of biological rules of size evolution, such as Cope's Rule (phyletic size increase), Rensch's Rule (allometric patterns of male and female size), as well as male and female body size optima. In certain spider groups, such as the golden orbweavers (Nephilidae), extreme female-biased SSD (eSSD, female:male body length ≥ 2) is the norm. Nephilid genera construct webs of exaggerated proportions, which can be aerial, arboricolous, or intermediate (hybrid). Read More
Sci Total Environ 2018 Nov 26;656:297-306. Epub 2018 Nov 26.
Department of Animal Physiology and Ecotoxicology, Faculty of Biology and Environmental Protection, University of Silesia, Bankowa 9, Katowice 40-007, Poland.
The study aimed at comparing the effects of short- and long-term exposure of Steatoda grossa female spiders to cadmium on the web's architecture, its energy content, and ultrastructure of ampullate glands. Simple food chain model (medium with 0.25 mM CdCl → Drosophila hydei flies → spider (for 4 weeks or 12 months) was used for the exposure. Read More
Oecologia 2018 Dec 3. Epub 2018 Dec 3.
Centre for Ecology, Evolution and Environmental Changes (cE3c), Faculdade de Ciências da Universidade de Lisboa, Edificio C2, 3º Piso Campo Grande, 1749-016, Lisbon, Portugal.
To fight infection, arthropods rely on the deployment of an innate immune response but also upon physical/chemical barriers and avoidance behaviours. However, most studies focus on immunity, with other defensive mechanisms being relatively overlooked. We have previously shown that the spider mite Tetranychus urticae does not mount an induced immune response towards systemic bacterial infections, entailing very high mortality rates. Read More
J Therm Biol 2018 Dec 29;78:298-303. Epub 2018 Oct 29.
Departamento de Ciencias Ecológicas, Facultad de Ciencias, Universidad de Chile, Chile; Instituto de Ecología y Evolución (IEB), Facultad de Ciencias, Universidad de Chile, Santiago, Chile.
Temperature is one of the most important environmental variables for organisms, especially for ectothermic animals. In fact, ectotherms must move within a relatively narrow range of temperatures where they are able to maximize their performance. We assessed the thermal ecology of female sand spiders (Sicarius thomisoides) in Chile from separate populations along an environmental gradient and different macro habitats (coast vs. Read More
FASEB J 2018 Dec 3:fj201801909R. Epub 2018 Dec 3.
Toxicology and Pharmacology, Katholieke Universiteit (KU) Leuven, Campus Gasthuisberg, Leuven, Belgium.
A 13 aa residue voltage-gated sodium channel (Na) inhibitor peptide, Pn, containing 2 disulfide bridges was designed by using a chimeric approach. This approach was based on a common pharmacophore deduced from sequence and secondary structural homology of 2 Na inhibitors: Conus kinoshitai toxin IIIA, a 14 residue cone snail peptide with 3 disulfide bonds, and Phoneutria nigriventer toxin 1, a 78 residue spider toxin with 7 disulfide bonds. As with the parent peptides, this novel Na channel inhibitor was active on Na1. Read More
Chemosphere 2018 Nov 27;218:758-766. Epub 2018 Nov 27.
Wrocław University of Science and Technology, Department of Environmental Protection, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland. Electronic address:
Fifteen polycyclic aromatic hydrocarbons (PAHs) were measured in the spider webs prepared in the laboratory and exposed to indoor air pollution in a defined period of time. We have selected homes differing in location (rural area vs. city), type of room (living room, kitchen, basement), inhabitants' habits (smoking cigarettes vs. Read More
Science 2018 11;362(6418):1052-1055
Center for Integrative Conservation, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Yunnan, 666303, China.
Lactation is a mammalian attribute, and the few known nonmammal examples have distinctly different modalities. We document here milk provisioning in a jumping spider, which compares functionally and behaviorally to lactation in mammals. The spiderlings ingest nutritious milk droplets secreted from the mother's epigastric furrow until the subadult stage. Read More
Toxicon 2018 Nov 26. Epub 2018 Nov 26.
Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia. Electronic address:
The millions of extant arthropod species are testament to their evolutionary success that can at least partially be attributed to venom usage, which evolved independently in at least 19 arthropod lineages. While some arthropods primarily use venom for predation (e.g. Read More
PLoS One 2018 29;13(11):e0208123. Epub 2018 Nov 29.
Department of Ecology and Evolutionary Biology, University of Kansas, Lawrence, Kansas, United States of America.
Group-living behavior is taxonomically widespread but rare in spiders. The conventional view is that the main pathways to group-living in spiders are either sub-social, where extended maternal care leads to prolonged sibling association; or communal living, where individuals aggregate to exploit a common resource. Female egg-sac guarding behavior occurs throughout kleptoparasitic spiders in the subfamily Argyrodinae (Theridiidae), while individuals in group-living species cohabit in the resource rich webs of their host spiders. Read More
Syst Rev 2018 Nov 28;7(1):211. Epub 2018 Nov 28.
Department of Pharmacology and Therapeutics, Mbarara University of Science and Technology, Mbarara, Uganda.
Background: The objective of the review was to synthesize evidence of barriers and facilitators to the integration of mental health services into PHC from existing literature. The structure of the review was guided by the SPIDER framework which involves the following: Sample or population of interest-primary care providers (PCPs); Phenomenon of Interest-integration of mental health services into primary health care (PHC); Design-influenced robustness and analysis of the study; Evaluation-outcomes included subjective outcomes (views and attitudes); and Research type-qualitative, quantitative, and mixed methods studies.
Methods: Studies that described mental health integration in PHC settings, involved primary care providers, and presented barriers/facilitators of mental health integration into PHC were included in the review. Read More
Cogn Emot 2018 Nov 28:1-12. Epub 2018 Nov 28.
b Baskent University , Department of Psychology , Ankara , Turkey.
Popular culture has many examples of evil characters having vertically pupilled eyes. Humans have a long evolutionary history of rivalry with snakes and their visual systems were evolved to rapidly detect snakes and snake-related cues. Considering such evolutionary background, we hypothesised that humans would perceive vertical pupils, which are characteristics of ambush predators including some of the snakes, as threatening. Read More
Zootaxa 2018 Nov 5;4513(1):1-90. Epub 2018 Nov 5.
The State Key Laboratory of Biocatalysis and Enzyme Engineering of China, Centre for Behavioural Ecology and Evolution, College of Life Sciences, Hubei University, Wuhan 430062, Hubei, China.
The genus Neriene Blackwall, 1833 from China is reviewed. Two new species are described: Neriene lushanensis n. sp. Read More
Zootaxa 2018 Nov 8;4514(3):301-331. Epub 2018 Nov 8.
Laboratório Especial de Coleções Zoológicas, Instituto Butantan. Av. Vital Brasil, 1500, CEP 05503-900, São Paulo, SP, Brazil..
Paracymbiomma gen. nov. is proposed to include six new species from Brazil: P. Read More
Zootaxa 2018 Nov 12;4518(1):1-76. Epub 2018 Nov 12.
Australian Centre for Evolutionary Biology and Biodiversity, and School of Biological Sciences, The University of Adelaide, Adelaide, SA 5005, Australia..
A combined molecular and morphological approach was used to revise the Australian spiny trapdoor spiders of the genus Blakistonia Hogg. Where possible, our molecular approach used sequence data from the COI barcoding gene, which were analysed using Bayesian, RAxML and neighbour-joining approaches. These molecular data were combined with morphology to describe and diagnose the genus, to redescribe the type (and only previously valid) species, B. Read More
Zootaxa 2018 Nov 13;4521(2):294-300. Epub 2018 Nov 13.
Laboratorio de Aracnología & Miriapodología (LAM-UN), Instituto de Ciencias Naturales, Departamento de Biología, Universidad Nacional de Colombia, Sede Bogotá, Colombia..
The huntsman spider genus Anaptomecus was proposed by Simon (1903) to include the type species, A. longiventris Simon, 1903, described from a juvenile male collected in Cayambé (San Pedro de Cayambé), Pichincha, Ecuador. Mello-Leitão (1940) described a second species, A. Read More
Zootaxa 2018 Nov 21;4524(2):245-250. Epub 2018 Nov 21.
A.N. Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, Leninsky prospekt 33, Moscow 119071, Russia..
Erigomicronus new genus is erected for Oreonetides longembolus Wunderlich Li, 1995 (the type species) and Maro lautus Saito, 1984. The genitalia of both species are studied in detail and illustrated. Based to the male palp conformation, the new genus seems to belong to the subfamily Erigoninae, but the epigynum resembles that of some "micronetine" genera, e. Read More
Zootaxa 2018 Nov 21;4524(2):174-186. Epub 2018 Nov 21.
Laboratório de Diversidade e Sistemática de Arachnida (LaDiSA). Universidade do Vale do Rio dos Sinos (UNISINOS). Av. Unisinos, 950, Cristo Rei, 93022-000 São Leopoldo, Rio Grande do Sul, Brazil..
The spider genus Stemmops O. Pickard-Cambridge, 1894, currently comprises 22 described species. Spiders of this genus are mainly known from the Neotropical Region, but are poorly studied in Brazil. Read More
Zootaxa 2018 Oct 16;4500(2):151-178. Epub 2018 Oct 16.
College of Life Science, Jinggangshan University, Ji'an 343009, Jiangxi, China College of Life Science, Hunan Normal University, Changsha 410081, Hunan, China.
Dictynidae spiders were collected from Jinggang Mountain National Nature Reserve, Jiangxi Province, China in the past four years. Five new species are described and illustrated with photographs, SEMs and line drawings: Lathys adunca Liu spec. nov. Read More
Zootaxa 2018 Oct 29;4508(1):141-150. Epub 2018 Oct 29.
The Key Laboratory of Invertebrate Systematics and Application, College of Life Sciences, Hebei University, Baoding, Hebei 071002, P. R. China.
In this paper, two new Paratus species are described from southern China from both sexes: Paratus hamatus sp. n. from Yunnan Province and P. Read More
Zootaxa 2018 Oct 31;4508(3):446-450. Epub 2018 Oct 31.
Museu Paraense Emílio Goeldi, Departamento de Zoologia, Laboratório de Aracnologia. Av. Perimetral, n° 1901, CEP 66077-830, Belém, Pará, Brazil.
At the time the genus Attacobius Mello-Leitão, 1925 was first acknowledged as a member of the subfamily Corinninae, Corinnidae, by Platnick Baptista (1995), only three species were recognized. Since then, that number has increased to 15 currently valid species (Bonaldo Brescovit 1998; 2005; Pereira-Filho et al. 2018). Read More
Zootaxa 2018 Oct 31;4508(3):431-434. Epub 2018 Oct 31.
Museum of Natural History, University of Wrocław, Sienkiewicza 21, 50-335 Wrocław, Poland..
The genus Plaumanniola Costa Lima, 1962 was a subject of several taxonomical and morphological studies. It is one of very few scydmaenines originally placed not only in a different beetle family, but even a superfamily. The first species of Plaumanniola, P. Read More
Zootaxa 2018 Nov 5;4514(1):1-22. Epub 2018 Nov 5.
Department of Biological Sciences, Graduate School of Science and Engineering, Tokyo Metropolitan University, Hachioji, Tokyo, Japan..
The systematics of the subgenus Stigmatodipogon Ishikawa of the genus Dipogon Fox is revised. Six species are listed. Two new species, Dipogon (Stigmatodipogon) kurokawai Shimizu, sp. Read More
An Bras Dermatol 2018 Nov/Dec;93(6):938-939
Department of Clinical and Surgical Dermatology and Venereology, Hospital Universitario de Fuenlabrada, Madrid, Spain.
Behav Res Ther 2018 Nov 20;112:28-35. Epub 2018 Nov 20.
University of North Carolina at Chapel Hill, Davie Hall, Campus Box 3270, Chapel Hill, NC, 27599-3270, United States.
Safety behaviors-actions performed to prevent, escape from, or reduce the severity of perceived threat-are typically eliminated during exposure therapy for clinical anxiety. Yet some experts have called for the strategic and "judicious use" of safety behaviors during exposure to improve treatment acceptability/tolerability without diminishing its efficacy. Empirical findings regarding this debate are mixed and existing work is subject to several methodological limitations. Read More
J Venom Anim Toxins Incl Trop Dis 2018 21;24:31. Epub 2018 Nov 21.
1Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av Antônio Carlos, 6627, 2nd Floor, Room 2031, Pampulha, Belo Horizonte, Minas Gerais 31270-901 Brazil.
Background: The great diversity of molecules found in spider venoms include amino acids, polyamines, proteins and peptides, among others. Some of these compounds can interact with different neuronal receptors and ion channels including those present in the ocular system. To study potential toxicity and safety of intravitreal injection in rabbits of LyeTx I b, a synthetic peptide derived from the toxin LyeTx I found in venom from the spider and to evaluate the angiogenic activity on a CAM model. Read More
Sci Rep 2018 Nov 27;8(1):17425. Epub 2018 Nov 27.
Nicolaus Copernicus University in Toruń, Department of Ecology and Biogeography, Lwowska 1, 87-100, Toruń, Poland.
Contrasting trophic theories of island biogeography try to link spatial patterns in species distribution and richness with dietary preferences, arguing that the spatial turnover of species among habitat patches changes with trophic rank causing a systematic change in the proportion of plants, herbivores, and predators across habitats of different size. Here we test these predictions using quantitative surveys of plants, spiders, and herbivores as well as of omnivorous and predatory ground beetles on undisturbed Polish lake islands. We found decreased proportions of predators and habitat generalists on larger islands. Read More
Oecologia 2018 Nov 26. Epub 2018 Nov 26.
Department of Integrative Biology, Oklahoma State University, 501 Life Sciences West, Stillwater, OK, 74075, USA.
Predators often feed on a wide range of prey that can vary in behavior, morphology, and physiology. The net benefits that predators gain from prey are likely related to both prey nutrient content and prey morphology or defenses. For invertebrates, the exoskeleton is a morphological trait that varies widely among species and during ontogeny and could affect nutrient extraction by predators. Read More
Emotion 2018 Nov 26. Epub 2018 Nov 26.
Swiss Center for Affective Sciences, University of Geneva.
Recent behavioral observations suggest an influence of prior expectancies on attention to neutral targets, whereas the detection of threatening targets remains comparably immune to these expectancies. The origin of this asymmetry, however, remains unclear. Here, therefore, we investigated its neural basis by using fMRI. Read More
Appl Plant Sci 2018 Nov 9;6(11):e01192. Epub 2018 Nov 9.
Institute of Fundamental Sciences Massey University Palmerston North 4442 New Zealand.
Premise Of The Study: Microsatellite markers were developed for New Zealand species of (Orchidaceae) to investigate population genetics and species delimitation.
Methods And Results: From sequencing a total genomic DNA library (using Illumina MiSeq), we developed 22 microsatellite markers for . The di- and trinucleotide repeat loci were initially trialed on individuals representing seven taxa (. Read More
Pak J Pharm Sci 2018 Nov;31(6):2537-2543
School of Biological Sciences, Universiti Sains Malaysia, Minden, Penang, Malaysia.
Spider lily (Hymenocallis littoralis) belongs to Amaryllidaceae family is a well-known plant species for its medicinal properties. The inhibitory effects of H. littoralis methanol sonication extracts were evaluated for wound healing activity. Read More
Toxins (Basel) 2018 Nov 22;10(12). Epub 2018 Nov 22.
Neurobiology and Venoms Laboratory (LNP), Department of Biology, College of Philosophy, Sciences and Literature of Ribeirão Preto, University of São Paulo, Av. Bandeirantes, 3900, Ribeirão Preto, 14040-901 São Paulo, Brazil.
Epilepsy is considered as one of the major disabling neuropathologies. Almost one third of adult patients with temporal lobe epilepsy (TLE) do not respond to current antiepileptic drugs (AEDs). Additionally, most AEDs do not have neuroprotective effects against the inherent neurodegenerative process underlying the hippocampal sclerosis on TLE. Read More
Ecol Evol 2018 Nov 13;8(21):10384-10394. Epub 2018 Oct 13.
Institute of Biodiversity and Ecosystem Dynamics University of Amsterdam Amsterdam The Netherlands.
When predators commonly overexploit local prey populations, dispersal drives the dynamics in local patches, which together form a metapopulation. Two extremes in a continuum of dispersal strategies are distinguished: the "Killer" strategy, where predators only start dispersing when all prey are eliminated, and the "Milker" strategy, in which predator dispersal occurs irrespective of prey availability. Theory shows that the Milker strategy is not evolutionarily stable if local populations are well connected by dispersal. Read More
JMIR Res Protoc 2018 Nov 21;7(11):e183. Epub 2018 Nov 21.
Universitat Jaume I, Castellon, Spain.
Background: Given the rise of internet-based treatments as an effective therapeutic tool for psychological disorders, it is necessary to carry out research that examines clients' experiences with this type of intervention. The qualitative methodology has been found to be useful for analyzing clients' perceptions in terms of facilitators and barriers, acceptability, and negative effects of internet-based treatments. However, a lack of integration of these primary studies has prevented their findings from being applied to new research and in clinical practice. Read More
Biochim Biophys Acta Biomembr 2019 Jan 12;1861(1):151-160. Epub 2018 Aug 12.
Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182-1030, USA. Electronic address:
Spider venom contains a number of small peptides that can control the gating properties of a wide range of ion channels with high affinity and specificity. These ion channels are responsible for coordination and control of many bodily functions such as transducing signals into sensory functions, smooth muscle contractions as well as serving as sensors in volume regulation. Hence, these peptides have been the topic of many research efforts in hopes that they can be used as biomedical therapeutics. Read More
Hum Resour Health 2018 11 21;16(1):63. Epub 2018 Nov 21.
Child and Adolescent Health Service, Health Department, Government of Western Australia, 189 Royal Street, East Perth, WA, 6004, Australia.
Background: Community-based health workers and volunteers are not just low-level health workforce; their effectiveness is also due to their unique relationship with the community and is often attributed to social capital, an area not well studied or acknowledged in the literature.
Methods: A qualitative meta-synthesis was conducted using the SPIDER framework and based on critical interpretive synthesis. The protocol was registered with PROSPERO, ID = CRD42018084130. Read More
Front Plant Sci 2018 6;9:1603. Epub 2018 Nov 6.
Laboratory of Plant and Environmental Biotechnology, Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece.
Beneficial microorganisms are known to promote plant growth and confer resistance to biotic and abiotic stressors. Soil-borne beneficial microbes in particular have shown potential in protecting plants against pathogens and herbivores via the elicitation of plant responses. In this study, we evaluated the role of strain K (FsK) in altering plant responses to the two spotted spider mite in tomato. Read More
J Comp Neurol 2018 Nov 20. Epub 2018 Nov 20.
Laboratory of Neuroethology, SOKENDAI (The Graduate University for Advanced Studies), Shonan Village, Hayama 240-0115, Japan.
Jumping spiders have four pairs of eyes (ocelli) of which only the principal eyes (PEs) are used to detect features of objects. Photoreceptors in the retina of the PEs form four layers (PL1-4) and terminate in the first optic ganglion (FOG). Here we focus on Hasarius adansoni because it has unique depth vision besides color vision and its FOG appears to contribute to the initial processing of these visual modalities. Read More
Biomacromolecules 2018 Nov 20. Epub 2018 Nov 20.
Oligonucleotide-spider silk conjugates can be placed on silicon wafers by complementary DNA strands, which are coupled chemically to the surface. Such specific immobilization of spider silk proteins allows, the nucleation and guided growth of β-sheet-rich nanofibrils in the presence of phosphate ions on the surface. Adjustment of the concentration of the immobilized conjugate, phosphate concentration and time of the assembly reaction enables control over fibril surface density and length. Read More
Sci Rep 2018 Nov 19;8(1):16990. Epub 2018 Nov 19.
MTA Centre for Ecological Research, Institute of Ecology and Botany, Vácrátót, Hungary.
There are only few studies that explore the ecological consequences of forest management on several organism groups. We studied the short-term effects of four forestry treatments including preparation cutting, clear-cutting, retention tree group and gap-cutting in a temperate managed forest on the assemblage structure of understory plants, enchytraeid worms, spiders and ground beetles. Here we show, that the effect of treatments on the different facets of assemblage structure was taxon-specific. Read More
Basic Clin Pharmacol Toxicol 2018 Nov 17. Epub 2018 Nov 17.
Laboratory of Toxicological Genetics, Lutheran University of Brazil (ULBRA), Farroupilha Avenue, 8001, 2425-900, Canoas, RS, Brazil.
Phα1β peptide isolated from the venom of the Phoneutria nigriventer spider has shown higher analgesic action in pre-clinical studies than ω-conotoxin MVIIA peptide used to treat severe chronic pain. In view of the great potential for the development of a new Phα1β-based drug, a Phα1β recombinant form (CTK 01512-2) has been studied for efficacy and safety. The aim of this study was to evaluate cytotoxic, genotoxic and mutagenic effects of a Phα1β recombinant form and compare it with native Phα1β and ω-conotoxin MVIIA. Read More
Amino Acids 2018 Nov 17. Epub 2018 Nov 17.
Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Antimicrobial peptides present a broad spectrum of therapeutic applications, including their use as anticancer peptides. These peptides have as target microbial, normal, and cancerous cells. The oncological properties of these peptides may occur by membranolytic mechanisms or non-membranolytics. Read More