7 results match your criteria Spectroscopy [Journal]

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Fourier Transform Infrared Spectroscopic Imaging of Fracture Healing in the Normal Mouse.

J Spectrosc (Hindawi) 2015 Jan;2015

Hospital for Special Surgery, 535 E. 70th Street, New York, NY 10021, USA.

Fourier transform infrared spectroscopic imaging (FTIRI) was used to study bone healing with spatial analysis of various callus tissues in wild type mice. Femoral fractures were produced in 28 male C57BL mice by osteotomy. Animals were sacrificed at 1, 2, 4, and 8 weeks to obtain callus tissue at well-defined healing stages. Read More

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http://dx.doi.org/10.1155/2015/659473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448139PMC
January 2015
8 Reads

Application of Paper Strip Extraction in Combination with LC-MS-MS in Pharmacokinetics.

Spectroscopy (Springf) 2013 Oct;39(10):s18-s25

Linus Pauling Institute and the College of Pharmacy at Oregon State University in Corvallis, Oregon.

Recent advances in sampling techniques in the pharmaceutical industry sparked significant interest in applying improvements to extraction methods for greater analyte detection and quantitation. In particular, the dried blood spot (DBS) sampling technique has numerous advantages compared to traditional methods such as liquid-liquid extraction, including the use of small sample volumes, less sample processing, and less exposure to toxic solvents (ether, methyl -butyl ether [MTBE], and dichloromethane). In this article, we discuss the adaptation of DBS technology to develop and validate a novel paper strip extraction method for the analysis of natural product metabolites in biological samples obtained from a human pharmacokinetic study of xanthohumol, a hop prenylflavonoid. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201118PMC
October 2013
9 Reads

Rapid bacterial diagnostics via surface enhanced Raman microscopy.

Spectroscopy (Springf) 2012 Jun;27(6):s8-31

Department of Chemistry, 590 Commonwealth Ave., Boston University, Boston MA 02215 ; Photonics Center, 15 Saint Mary's St., Boston University, Boston MA 02215.

There is a continuing need to develop new techniques for the rapid and specific identification of bacterial pathogens in human body fluids especially given the increasing prevalence of drug resistant strains. Efforts to develop a surface enhanced Raman spectroscopy (SERS) based approach, which encompasses sample preparation, SERS substrates, portable Raman microscopy instrumentation and novel identification software, are described. The progress made in each of these areas in our laboratory is summarized and illustrated by a spiked infectious sample for urinary tract infection (UTI) diagnostics. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872130PMC
June 2012
7 Reads

Sample Preparation Problem Solving for Inductively Coupled Plasma-Mass Spectrometry with Liquid Introduction Systems I. Solubility, Chelation, and Memory Effects.

Authors:
R Steven Pappas

Spectroscopy (Springf) 2012 May;27(5):20-31

Division of Laboratory Sciences, National Center for Environmental Health, U.S. Centers for Disease Control and Prevention, Atlanta, GA, USA 30341-3717,

This tutorial was adapted from the first half of a course presented at the 7th International Conference on Sector Field Inductively Coupled Plasma Mass Spectrometry in 2008 and the 2012 Winter Conference on Plasma Spectrochemistry on sample preparation for liquid introduction systems. Liquid introduction in general and flow injection specifically are the most widely used sample introduction methods for inductively coupled plasma-mass spectrometry. Nevertheless, problems persist in determination of analytes that are commonly investigated, as well as in specialty applications for those seldom considered by most analysts. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550584PMC
May 2012
19 Reads

The Role of Naturally Occurring Stable Isotopes in Mass Spectrometry, Part III: Small Gas Molecule Calculations.

Spectroscopy (Springf) 2009 Sep;24(9):34

Medical Research Council Human Nutrition Research, Cambridge, UK.

In the third instalment of this tutorial, the authors explain the determination of the isotopic composition of a sample from a mass spectrometric measurement, and the methods of calculation as well as the units used. This tutorial outlines the practices in common usage, so that researchers new to this field can obtain a good understanding of the fundamentals involved. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678118PMC
September 2009
11 Reads

The Role of Naturally Occurring Stable Isotopes in Mass Spectrometry, Part I: The Theory.

Spectroscopy (Springf) 2009 Mar;23(10):36

Medical Research Council Human Nutrition Research, Cambridge, UK.

In this tutorial, the authors explain how naturally occurring stable isotopes are contributing to experimentally determined mass spectra and how this information can be exploited in quantitative experiments, structural elucidation studies and tracer methodologies. The first instalment of this two part series focuses on the theoretical aspects of stable isotopes and the calculation of their distribution patterns. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679491PMC
March 2009
24 Reads

The Role of Naturally Occurring Stable Isotopes in Mass Spectrometry, Part II: The Instrumentation.

Spectroscopy (Springf) 2009 Feb;24(2):50

Medical Research Council Human Nutrition Research, Cambridge, UK.

In the second instalment of this tutorial, the authors explain the instrumentation for measuring naturally occurring stable isotopes, specifically the magnetic sector mass spectrometer. This type of instrument remains unrivalled in its performance for isotope ratio mass spectrometry (IRMS) and the reader is reminded of its operation and its technical advantages for isotope measurements. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679492PMC
February 2009
6 Reads
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