752,342 results match your criteria Spectroscopy [Journal]


A 12-wk whole-grain wheat intervention protects against hepatic fat: the Graandioos study, a randomized trial in overweight subjects.

Am J Clin Nutr 2018 Dec;108(6):1264-1274

Wageningen University, Division of Human Nutrition, Wageningen, The Netherlands.

Background: Whole-grain wheat (WGW) is described as nutritionally superior to refined wheat (RW) and thus advocated as the healthy choice, although evidence from intervention studies is often inconsistent. The liver, as the central organ in energy metabolism, might be an important target organ for WGW interventions.

Objective: The aim of this study was to investigate the potential benefits of WGW consumption compared with RW consumption on liver health and associated parameters. Read More

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December 2018

Scattering characteristics of an exciton-plasmon nanohybrid made by coupling a monolayer graphene nanoflake to a carbon nanotube.

J Phys Condens Matter 2018 Dec 12. Epub 2018 Dec 12.

Advanced Computing and Simulation Laboratory, Monash University, Clayton,, Victoria 3800, Melbourne, Victoria, 3800, AUSTRALIA.

A hybrid nanostructure where a graphene nanoflake (GNF) is optically coupled to a carbon nanotube (CNT) could potentially possess enhanced sensing capabilities compared to the individual constituents whilst inheriting their high biocompatibility, favourable electrical, mechanical and spectroscopic properties. Therefore, in this paper, we investigate the scattering characteristics of an all-carbon exciton-plasmon nanohybrid which was made by coupling an elliptical GNF resonator to a semiconducting CNT gain element. We analytically model the nanohybrid as an open quantum system using cavity quantum electrodynamics. Read More

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December 2018

Coherent optical and acoustic phonons generated at lattice-matched GaP/Si(001) heterointerfaces.

J Phys Condens Matter 2018 Dec 12. Epub 2018 Dec 12.

Department of Physics, University of Florida, P.O. Box 118440, Gainesville, Florida, 32611, UNITED STATES.

Thin GaP films can be grown on an exact Si(001) substrate with nearly perfect lattice match. We perform all-optical pump-probe measurements to investigate the ultrafast electron-phonon coupling at the buried interface of GaP/Si. Above-bandgap excitation with a femtosecond laser pulse can induce coherent longitudinal optical (LO) phonons both in the GaP opverlayer and in the Si substrate. Read More

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December 2018

A fistulating oropharyngeal lesion.

Ear Nose Throat J 2018 Dec;97(12):E15-E17

Department of Otorhinolaryngology-Head and Neck Surgery, Mayo Clinic Arizona, 5777 E. Mayo Blvd., Phoenix, AZ 85084, USA.

Post-transplant lymphoproliferative disorder (PTLD) is a unifying term for a spectrum of lymphoid expansion entities brought about by immunosuppression. It can present throughout the head and neck, and tonsillar involvement is not limited to children. We report the case of a 67-year-old woman who developed odynophagia associated with putrid halitosis 4 months after she had undergone renal transplantation. Read More

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December 2018

Assessing the potential of sputtered gold nanolayers in mass spectrometry imaging for metabolomics applications.

PLoS One 2018 12;13(12):e0208908. Epub 2018 Dec 12.

Department of Electronic Engineering, Universitat Rovira i Virgili, Tarragona, Spain.

Mass spectrometry imaging (MSI) is a molecular imaging technique that maps the distribution of molecules in biological tissues with high spatial resolution. The most widely used MSI modality is matrix-assisted laser desorption/ionization (MALDI), mainly due to the large variety of analyte classes amenable for MALDI analysis. However, the organic matrices used in classical MALDI may impact the quality of the molecular images due to limited lateral resolution and strong background noise in the low mass range, hindering its use in metabolomics. Read More

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December 2018

Effects of Mirror-Box Therapy on Modulation of Sensorimotor EEG Oscillatory Rhythms: A Single-Case Longitudinal Study.

J Neurophysiol 2018 Dec 12. Epub 2018 Dec 12.

3Pacific Development and Technology, LLC.

We provide direct electrophysiological evidence that Mirror Therapy (MT) can change brain activity and aid in recovery of motor function after stroke. In this longitudinal single-case study, the subject was a 58-year-old man with right-hand hemiplegia due to ischemic stroke. Over a nine-month period we treated him with MT twice a week and measured electroencephalograms (EEG) before, during, and after each therapy session. Read More

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December 2018

Kinetics and mechanism of pyrrolidine buffer-catalyzed fulvene formation.

J Org Chem 2018 Dec 12. Epub 2018 Dec 12.

Rapid synthesis of fulvenes is achieved using pyrrolidinium/pyrrolidine buffers in anhydrous acetonitrile. Time-dependent UV-Vis absorption and NMR spectroscopy reveal that the rate and yield of fulvene formation depend strongly on both the presence of acid in the medium and the choice of solvent, and are negatively affected by water. Kinetic data have been collected for various substrates, and the synthetic benefits of the adjusted reaction conditions are showcased. Read More

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December 2018

Energy-Degeneracy-Driven Covalency in Actinide Bonding.

J Am Chem Soc 2018 Dec 12. Epub 2018 Dec 12.

Los Alamos National Laboratory , P.O. Box 1663, Los Alamos , New Mexico 87545 , United States.

Evaluating the nature of chemical bonding for actinide elements represents one of the most important and long-standing problems in actinide science. We directly address this challenge and contribute a Cl K-edge X-ray absorption spectroscopy and relativistic density functional theory study that quantitatively evaluates An-Cl covalency in AnCl (An = Th, U, Np, Pu). The results showed significant mixing between Cl 3p- and An 5f- and 6d-orbitals (t*/t* and t*/e *), with the 6d-orbitals showing more pronounced covalent bonding than the 5f-orbitals. Read More

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December 2018

Solvent welding and imprinting cellulose nanofiber films using ionic liquids.

Biomacromolecules 2018 Dec 12. Epub 2018 Dec 12.

Cellulose nanofiber films (CNFF), were treated via a welding process using ionic liquids (ILs). Acid-base conjugated ILs derived from 1,5-diazabicyclo[4.3. Read More

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December 2018
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Fundamentally Different Distance Dependences of Electron-Transfer Rates for Low and High Driving Forces.

Inorg Chem 2018 Dec 12. Epub 2018 Dec 12.

Department of Chemistry , University of Basel , St. Johanns-Ring 19 , 4056 Basel , Switzerland.

The distance dependences of electron-transfer rates ( k) in three homologous series of donor-bridge-acceptor compounds with reaction free energies (Δ G) of ca. -1.2, -1. Read More

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December 2018

Refluxed Esterification of Fullerenes Conjugated P25 TiO2 Promotes Free Radical Scavenging Capacity and Facilitates Anti-aging Potentials in Human Cells.

ACS Appl Mater Interfaces 2018 Dec 12. Epub 2018 Dec 12.

Titanium dioxide nanomaterials have good capability to prevent human cells from damage under UV irradiation. However, some studies indicated that the nanoscale of titanium dioxide could potentially cause harmful effects such as free radicals generation under UV irradiation and thereby accelerate the progress of cell aging. Fullerenes can scavenge large amounts of free radicals due to the fact that fullerenes contain enormous amount of π electrons with low lying lowest unoccupied molecular orbital (LUMO), but its adverse properties, such as the poor solubility in water, restricted the applicability. Read More

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December 2018

How the methyl group position influences the ultrafast deactivation in aromatic radicals.

Phys Chem Chem Phys 2018 Dec 12. Epub 2018 Dec 12.

Paul Scherrer Institute, CH-5232 Villigen-PSI, Switzerland.

Excited xylyl (methyl-benzyl) radical isomers have been studied by femtosecond time-resolved photoelectron spectroscopy and mass spectrometry. Depending on the substitution we find different deactivation channels after excitation into the D3(2A'') state (310 nm, 4 eV). While the ortho and para isomer exhibit deactivation rates similar to the benzyl radical, meta-xylyl sticks out and depletes twice as fast into the vibrationally hot ground state. Read More

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December 2018

Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association.

Elife 2018 Dec 12;7. Epub 2018 Dec 12.

Department of Cell Biology, Yale University School of Medicine, New Haven, United States.

Sec1/Munc18-family (SM) proteins are required for SNARE-mediated membrane fusion, but their mechanism(s) of action remain controversial. Using single-molecule force spectroscopy, we found that the SM protein Munc18-1 catalyzes step-wise zippering of three synaptic SNAREs (syntaxin, VAMP2, and SNAP-25) into a four-helix bundle. Catalysis requires formation of an intermediate template complex in which Munc18-1 juxtaposes the N-terminal regions of the SNARE motifs of syntaxin and VAMP2, while keeping their C-terminal regions separated. Read More

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December 2018
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Changes in cerebral oxygenation and cerebral blood flow during hemodialysis - A simultaneous near-infrared spectroscopy and positron emission tomography study.

J Cereb Blood Flow Metab 2018 Dec 12:271678X18818652. Epub 2018 Dec 12.

1 Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Near-infrared spectroscopy (NIRS) is used to monitor cerebral tissue oxygenation (rSO) depending on cerebral blood flow (CBF), cerebral blood volume and blood oxygen content. We explored whether NIRS might be a more easy applicable proxy to [O]HO positron emission tomography (PET) for detecting CBF changes during hemodialysis. Furthermore, we compared potential determinants of rSO and CBF. Read More

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December 2018

Higher physiological vulnerability to hypoxic exposure with advancing age in the human brain.

J Cereb Blood Flow Metab 2018 Dec 12:271678X18818291. Epub 2018 Dec 12.

1 Functional Imaging Unit, Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital Rigshospitalet, Glostrup, Denmark.

The aging brain is associated with atrophy along with functional and metabolic changes. In this study, we examined age-related changes in resting brain functions and the vulnerability of brain physiology to hypoxic exposure in humans in vivo. Brain functions were examined in 81 healthy humans (aged 18-62 years) by acquisitions of gray and white matter volumes, cerebral blood flow, cerebral oxygen consumption, and concentrations of lactate, N-acetylaspartate, and glutamate+glutamine using magnetic resonance imaging and spectroscopy. Read More

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December 2018

Cation Exchange at the Interfaces of Ultrathin Films of Fluorous Ionic Liquids on Ag(111).

Langmuir 2018 Dec 12. Epub 2018 Dec 12.

In the context of applications with thin ionic liquid (IL) films on solid supports, we studied the ion distribution within mixed thin IL films by angle-resolved X-ray photoelectron spectroscopy. After deposition of 1-methyl-3-octylimidazolium hexafluorophosphate, [CCIm][PF], on top of a wetting layer (WL) of 3-methyl-1-(3,3,4,4,4-pentafluorobutyl)imidazolium hexafluorophosphate, [PFBMIm][PF], on Ag(111) at room temperature (RT), we find a preferential enrichment of the [PFBMIm] cation at the IL/vacuum interface. In a similar deposition experiment at 82 K, this cation exchange at the IL/solid interface does not occur. Read More

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December 2018

TiO2 Nanoparticles Catalyze Oxidation of Huntingtin Exon 1-Derived Peptides Impeding Aggregation: a Quantitative NMR Study of Binding and Kinetics.

J Am Chem Soc 2018 Dec 12. Epub 2018 Dec 12.

Polyglutamine expansion within the N-terminal region of the huntingtin protein results in the formation of intracel-lular aggregates responsible for Huntington's disease, a fatal neurodegenerative condition. The interaction be-tween TiO2 nanoparticles and huntingtin peptides com-prising the N-terminal amphiphilic domain without (httNT) or with (httNTQ10) a ten-residue C-terminal polyglutamine tract, is investigated by NMR spectroscopy. TiO2 nanopar-ticles decrease aggregation of httNTQ10 by catalyzing the oxidation of Met7 to a sulfoxide, resulting in an aggrega-tion-incompetent peptide. Read More

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December 2018

A Novel Near-infrared Hyperspectral Absorption/Scattering Imaging Method using Multiple Ground Plates for Evaluating Polymer Composites.

Anal Chem 2018 Dec 12. Epub 2018 Dec 12.

This paper proposes a nondestructive method of evaluating polymer composites using near-infrared (NIR) diffuse reflection spectroscopy with multiple ground plates. Wavelength-dependent absorption and reduced scattering coefficients were acquired to evaluate the chemical structure and the concentration of the substances from absorption and to determine the size and the dispersity of filler in the polymer domain from scattering. NIR spectra of the sample were measured on multiple ground plates, namely, "ground-plate-dependent" diffuse reflection spectra. Read More

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December 2018

Distinct Binding Characteristics of Pathogenic Anti-Platelet Factor-4/Polyanion Antibodies to Antigens Coated on Different Substrates: A Perspective on Clinical Application.

ACS Nano 2018 Dec 12. Epub 2018 Dec 12.

Institute for Immunology and Transfusion Medicine , University Medicine Greifswald , 17475 Greifswald , Germany.

The polyanion heparin, which is frequently used in patients, complexes with the platelet-derived cationic chemokine platelet factor (PF4, CXCL4). This results in the formation of anti-PF4/heparin antibodies (anti-PF4/H Abs). Anti-PF4/H Abs are classified into three groups: (i) nonpathogenic Abs (group 1) with no clinical relevance; (ii) pathogenic heparin-dependent Abs (group 2), which activate platelets and can cause the severe adverse drug effect heparin-induced thrombocytopenia (HIT); and (iii) pathogenic autoimmune-HIT Abs (group 3), in which group 3 anti-PF4/H Abs causes a HIT-like autoimmune disease in the absence of heparin. Read More

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December 2018
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Frontal hypoactivation and alterations in the reward-system during humor processing in patients with schizophrenia spectrum disorders.

Schizophr Res 2018 Dec 30;202:149-157. Epub 2018 Jun 30.

Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Rudolf-Bultmann-Straße 8, 35039 Marburg, Germany.

Humor is a ubiquitous human ability with important implications for both social and emotional functioning. Patients with neuropsychiatric disorders, such as schizophrenia, experience difficulties in the comprehension and appreciation of humor. However, the specific neural mechanisms underlying these deficits are unknown. Read More

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December 2018

Sustainable Barrier System via Self-assembly of Colloidal Montmorillonite and Crosslinking Resins on Nanocellulose Interfaces.

ACS Appl Mater Interfaces 2018 Dec 12. Epub 2018 Dec 12.

Cellulose nanofibrils (CNFs) are able to form strong oxygen-barrier films suitable for food packaging but lack the needed water resistance in comparison to plastics. Desired water barrier quality can be achieved by applying mineral additives within the nanofibrils network. In current contribution, a sustainable hybrid system with improved water-barrier function is proposed by incorporating colloidal montmorillonite nano-clay (MMT) and two crosslinking agents namely; polyamidoamine epichlorohydrin (PAE) and Acrodur® thermoset acrylic resin (ACR) into CNF interfaces. Read More

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December 2018

Synthesis and Evaluation of Novel Neamine-Nucleoside Conjugates as Potential Antibiotic Targets for Escherichia coli 16S Ribosomal RNA.

Methods Mol Biol 2019 ;1870:151-163

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.

Based on the nucleobase rich character of the binding pocket of A-site 16S ribosomal RNA of Escherichia coli, it was proposed that the neamine moiety of synthesized Neamine-nucleoside conjugates could bind to the groove of RNA while the nucleobase moiety would bind specifically to the sequence of the 16S rRNA A-site fragment. Thus the designed conjugate compound 5 was found to have the same dissociation constant as neamine for binding to 16S rRNA and the neamine-amino acid substituted nucleoside conjugate 8 and 9 showed 6.3 and 4. Read More

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January 2019

Hydrothermal carbonization of arecanut husk biomass: fuel properties and sorption of metals.

Environ Sci Pollut Res Int 2018 Dec 11. Epub 2018 Dec 11.

Department of Bioenergy, Tamil Nadu Agricultural University, Coimbatore, Tamil Nadu, 641003, India.

In this study, hydrothermal carbonization of arecanut husk and its potential application as an alternate solid fuel and heavy metal sorption (adsorbent) was attempted. Arecanut husk (AH) treated with citric acid for 9 h resulted in the hydrochar yield of 58.7% with increased fixed carbon from 17 to 39. Read More

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December 2018

Chemical fractionation of heavy metals in fine particulate matter and their health risk assessment through inhalation exposure pathway.

Environ Geochem Health 2018 Dec 11. Epub 2018 Dec 11.

Department of Chemistry, Dayalbagh Educational Institute, Agra, U.P., 282005, India.

Samples of PM were collected from an urban area close to a national highway in Agra, India and sequentially extracted into four different fractions: water soluble (F1), reducible (F2), oxidizable (F3) and residual fraction (F4) for chemical fractionation of arsenic (As), cadmium (Cd), cobalt (Co), chromium (Cr), nickel (Ni) and lead (Pb). The metals were analyzed by inductively coupled plasma optical emission spectroscopy in each fraction. The average mass concentration of PM was 93 ± 24 μg m. Read More

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December 2018
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Synthesis, characterization and catalytic epoxidation properties of a new tellurotungstate(iv)-supported rhenium carbonyl derivative.

Dalton Trans 2018 Dec 12. Epub 2018 Dec 12.

Henan Key Laboratory of Polyoxometalate Chemistry, Institute of Molecular and Crystal Engineering, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, Henan 475004, P. R. China.

A monomeric tellurotungstate(iv)-supported rhenium carbonyl derivative: Na2H2[(CH3)4N]6[Te2W20O70{Re(CO)3}2]·20H2O (1) has been successfully isolated and structurally characterized by single crystal X-ray diffraction crystallography, IR and UV-Vis spectroscopy, thermogravimetric analysis, etc. In particular, complex 1 could act as a efficient and reusable heterogeneous catalyst for selective epoxidation of various alkenes including different cycloalkenes, styrene derivatives, internal and long-chain alkenes. For example, cis-cyclooctene undergoes up to 98. Read More

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December 2018
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Swelling behaviour of core-shell microgels in HO, analysed by temperature-dependent FTIR spectroscopy.

Phys Chem Chem Phys 2018 Dec 12. Epub 2018 Dec 12.

Physical and Biophysical Chemistry, Department of Chemistry, Bielefeld University, Universitätsstr. 25, 33615 Bielefeld, Germany.

Stimuli-responsive microgels are colloidal particles and promising candidates for applications such as targeted drug delivery, matrices for catalysts, nanoactuators and smart surface coatings. To tailor the response, the architecture of microgels is of paramount importance with respect to these applications. Statistical copolymer microgels based on N-isopropylmethacrylamide (NiPMAM) and N-n-propylacrylamide (NnPAM) show a cooperative phase transition leading to a collapse at a specific temperature. Read More

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December 2018

Dynamic thermal emission control with InAs-based plasmonic metasurfaces.

Sci Adv 2018 Dec 7;4(12):eaat3163. Epub 2018 Dec 7.

Geballe Laboratory for Advanced Materials, Stanford University, Stanford, CA 94305, USA.

Thermal emission from objects tends to be spectrally broadband, unpolarized, and temporally invariant. These common notions are now challenged with the emergence of new nanophotonic structures and concepts that afford on-demand, active manipulation of the thermal emission process. This opens a myriad of new applications in chemistry, health care, thermal management, imaging, sensing, and spectroscopy. Read More

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December 2018

Comparison of speed versus complexity effects on the hemodynamic response of the trail making test in block designs.

Neurophotonics 2018 Oct 8;5(4):045007. Epub 2018 Dec 8.

University Hospital Tuebingen, Department of Psychiatry and Psychotherapy, Tuebingen, Germany.

The use of functional near-infrared spectroscopy (fNIRS) in block designs provides measures of cortical activity in ecologically valid environments. However, in some cases, the use of block designs may be problematic when data are not corrected for performance in a time-restricted block. We sought to investigate the effects of task complexity and processing speed on hemodynamic responses in an fNIRS block design. Read More

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October 2018

Antimicrobial Fatty Acids from Green Alga (Chlorophyta).

Biomed Res Int 2018 13;2018:3069595. Epub 2018 Nov 13.

Laboratory of Blue Biotechnology and Aquatic Bioproduction (B3 Aqua), National Institute of Marine Sciences and Technologies (INSTM), 28, 2 march street 1934 -2035 Salammbô, Tunisia.

This study deals with the antimicrobial potential assessment of in regard to collection period and sampling site. Besides, we assess the chemical composition of bioactive compounds. For this purpose, was seasonally collected from two northern sites in Tunisia, Cap Zebib rocky shore (CZ) and Ghar El Melh lagoon (GEM). Read More

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November 2018

Evaluation of the Starch Quantification Methods of and Using Factorial Experiments.

Int J Food Sci 2018 13;2018:5901930. Epub 2018 Nov 13.

Universidad de Cartagena, Cartagena de Indias, Colombia.

Background: Starch and its products are used in a variety of ways for both the food and nonfood industries. A factorial experiment is carried out with two factors to explain the behavior of the percentage of starch, where the factors correspond to the extraction method and to the raw material.

Method: Three methods were used in triplicate: the first followed the official technique of the Association of Official Analytical Chemists (AOAC), to perform acid hydrolysis and quantification of starch by Titulation; the second method involved the colorful reaction with iodine using the UV equipment to measure the absorbance and calculate the percentage of starch; as a third method the FTIR was used, through which the concentration of the starch was calculated by the area under the curve obtained from the spectrum. Read More

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November 2018

Solid Contact Potentiometric Sensors Based on a New Class of Ionic Liquids on Thiacalixarene Platform.

Front Chem 2018 27;6:594. Epub 2018 Nov 27.

Department of Organic Chemistry, A. M. Butlerov' Chemistry Institute, Kazan Federal University, Kazan, Russia.

New solid-contact potentiometric sensors have been developed for hydrogen phosphate recognition on the basis of ionic liquids containing tetrasubstituted derivatives of thiacalix[4]arene in and conformations with trimethyl- and triethylammonium fragments at the lower rim substituents. The recognition of selected anions including carbonate, hydrogen phosphate, perchlorate, oxalate, picrate, and EDTA was conducted using electrochemical impedance spectroscopy with ferricyanide redox probe. For the potentiometric sensor assembling, the ionic liquids were stabilized by multiwalled carbon nanotubes and carbon black deposited on the glassy carbon electrode. Read More

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November 2018

Social Thinking®, Pseudoscientific, Not Empirically Supported, and Non-Evidence Based: a Reply to Crooke and Winner.

Behav Anal Pract 2018 Dec 8;11(4):456-466. Epub 2018 Mar 8.

Autism Partnership Foundation, 200 Marina Drive, Seal Beach, CA 90740 USA.

J. B. Leaf et al. Read More

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December 2018

Toward an Understanding of the Essential Components of Behavior Analytic Service Plans.

Behav Anal Pract 2018 Dec 20;11(4):436-444. Epub 2018 Apr 20.

3Western Michigan Univesity, Kalamazoo, MI USA.

Baer, Wolf, and Risley (1968) indicated "technological" was one of seven core dimensions of applied behavior analysis (ABA). They described this dimension as being met if interventions were described well enough to be implemented correctly. Often in the applied settings, a behavior plan is the method by which interventions are communicated to staff and parents for implementation. Read More

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December 2018

Procyanidins Extracted from Lotus Seedpod Ameliorate Amyloid--Induced Toxicity in Rat Pheochromocytoma Cells.

Oxid Med Cell Longev 2018 28;2018:4572893. Epub 2018 Oct 28.

Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Alzheimer's disease (AD) is a progressive neurodegenerative disease, which is characterized by extracellular senile plaque deposits, intracellular neurofibrillary tangles, and neuronal apoptosis. Amyloid- (A) plays a critical role in AD that may cause oxidative stress and downregulation of CREB/BDNF signaling. Anti-A effect has been discussed as a potential therapeutic strategy for AD. Read More

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October 2018

A Single Common Assay for Robust and Rapid Fragile X Mental Retardation Syndrome Screening From Dried Blood Spots.

Front Genet 2018 27;9:582. Epub 2018 Nov 27.

Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

CGG trinucleotide repeat hyper-expansions are observed in 99% of individuals with fragile X mental retardation syndrome (FXS). We evaluated the reliability of a rapid single-step gender-neutral molecular screen for FXS when performed on DNA isolated from dried blood spots. DNA was extracted from dried blood spots of 151 individuals with intellectual disability or autism spectrum disorder, whose repeat genotypes are known. Read More

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November 2018

Short Symmetric-End Antimicrobial Peptides Centered on β-Turn Amino Acids Unit Improve Selectivity and Stability.

Front Microbiol 2018 27;9:2832. Epub 2018 Nov 27.

The Laboratory of Molecular Nutrition and Immunity, Institute of Animal Nutrition, Northeast Agricultural University, Harbin, China.

Antimicrobial peptides (AMPs) are excellent candidates to combat the increasing number of multi- or pan-resistant pathogens worldwide based on their mechanism of action, which is different from that of antibiotics. In this study, we designed short peptides by fusing an α-helix and β-turn sequence-motif in a symmetric-end template to promote the higher cell selectivity, antibacterial activity and salt-resistance of these structures. The results showed that the designed peptides PQ and PP tended to form an α-helical structure upon interacting with a membrane-mimicking environment. Read More

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November 2018

Dimethyl 2,2'-[2,2'-(ethane-1,1-diyl)bis(1-indole-3,2-diyl)]-diacetate: a small molecule capable of nano-scale assembly, inhibiting venous thrombosis and inducing no bleeding side effect.

Int J Nanomedicine 2018 22;13:7835-7844. Epub 2018 Nov 22.

Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China,

Background: Due to the discovery that deep venous thrombosis (DVT) inhibitor is of chemotherapeutic importance, the nano-property of dimethyl 2,2'-[2,2'-(ethane-1,1-diyl) bis(1-indole-3,2-diyl)]-diacetate (DEBIC), a recently reported antitumor agent, is worthy of characterization.

Materials And Methods: One-pot reaction was used to prepare DEBIC. Electrospray Ionization (+/-)-Fourier Transform-Ion Cyclotron Resonance-Mass Spectrometer (ESI(+/-)-FT-ICR-MS), quadrupole Collision Induced Dissociation (qCID) and nuclear overhauser effect spectroscopy spectra were used to present the assembly of DEBIC. Read More

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November 2018

Biogenic pentagonal silver nanoparticles for safer and more effective antibacterial therapeutics.

Int J Nanomedicine 2018 21;13:7789-7799. Epub 2018 Nov 21.

Nanomedicine & Nanobiotechnology Lab, Department of Biosciences, Integral University, Dasauli, Lucknow, India,

Background: Biological synthesis of nanomaterials possesses unprecedented potential in the production of nanomaterials due to their ability to produce nanomaterials with improved biocompatibility in addition to eco-friendly synthetic procedures.

Methods: This article reports the isolation of an air-borne fungus from the campus of Integral University, Lucknow, with an exceptional ability to withstand very high concentrations of silver salt. The fungus was found to produce pentagonal silver nanoparticles (AgPgNps) when silver ions were reduced from silver nitrate. Read More

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November 2018

Decapeptide functionalized targeted mesoporous silica nanoparticles with doxorubicin exhibit enhanced apoptotic effect in breast and prostate cancer cells.

Int J Nanomedicine 2018 19;13:7669-7680. Epub 2018 Nov 19.

Nanobioscience Group, Agharkar Research Institute, Pune, India,

Background: Considering the increase in cancer cases and number of deaths per year worldwide, development of potential therapeutics is imperative. Mesoporous silica nanoparticles (MSNPs) are among the potential nanocarriers having unique properties for drug delivery. Doxorubicin (DOX), being the most commonly used drug, can be efficiently delivered to gonadotropin-releasing hormone (GnRH)-overexpressing cancer cells using functionalized MSNPs. Read More

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November 2018

Structural and functional comparability study of anti-CD20 monoclonal antibody with reference product.

Biologics 2018 23;12:159-170. Epub 2018 Nov 23.

Sun Pharmaceutical Industries Limited, Tandalja, Vadodara 390 012, India,

Background: Cell surface protein, CD20, is extensively expressed on the surface of B cells. Antibodies targeting CD20 protein are being used to treat B-cell malignancies and B-cell mediated autoimmune diseases. Considering the cost of therapy with innovator monoclonal antibodies for these diseases, development of biosimilar products for the treatment of such diseases provides affordable solution to rising healthcare costs. Read More

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November 2018

Histone demethylase LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis.

Nat Immunol 2019 Jan 10;20(1):86-96. Epub 2018 Dec 10.

Department of Medicine, Division of Hematology & Medical Oncology, Weill Cornell Medicine, New York, NY, USA.

Germinal center (GC) B cells feature repression of many gene enhancers to establish their characteristic transcriptome. Here we show that conditional deletion of Lsd1 in GCs significantly impaired GC formation, associated with failure to repress immune synapse genes linked to GC exit, which are also direct targets of the transcriptional repressor BCL6. We found that BCL6 directly binds LSD1 and recruits it primarily to intergenic and intronic enhancers. Read More

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January 2019

The soil organic matter decomposition mechanisms in ectomycorrhizal fungi are tuned for liberating soil organic nitrogen.

ISME J 2018 Dec 11. Epub 2018 Dec 11.

Department of Biology, Microbial Ecology Group, Lund University, Ecology Building, SE-223 62, Lund, Sweden.

Many trees form ectomycorrhizal symbiosis with fungi. During symbiosis, the tree roots supply sugar to the fungi in exchange for nitrogen, and this process is critical for the nitrogen and carbon cycles in forest ecosystems. However, the extents to which ectomycorrhizal fungi can liberate nitrogen and modify the soil organic matter and the mechanisms by which they do so remain unclear since they have lost many enzymes for litter decomposition that were present in their free-living, saprotrophic ancestors. Read More

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December 2018

Bioconjugation strategy for cell surface labelling with gold nanostructures designed for highly localized pH measurement.

Nat Commun 2018 12 11;9(1):5278. Epub 2018 Dec 11.

Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho, Kawaramachi-Hirokoji, Kyoto, 602-8566, Japan.

Regulation of intracellular pH is critically important for many cellular functions. The quantification of proton extrusion in different types of cells and physiological conditions is pivotal to fully elucidate the mechanisms of pH homeostasis. Here we show the use of gold nanoparticles (AuNP) to create a high spatial resolution sensor for measuring extracellular pH in proximity of the cell membrane. Read More

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December 2018

Plasma DNA Analysis in Prostate Cancer: Opportunities for Improving Clinical Management.

Clin Chem 2018 Dec 11. Epub 2018 Dec 11.

University College London Cancer Institute, London, UK

Background: Molecular characterization of tumors could be important for clinical management. Plasma DNA obtained noninvasively as a liquid biopsy could be widely applicable for clinical implementation in biomarker-based treatment strategies.

Content: Prostate cancer is a disease with variable clinical outcomes and molecular features and therefore presents multiple opportunities for biomarker-based treatment optimization. Read More

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December 2018

A quarter of a century of SERF: The progress of an NMR pulse sequence and its application.

Authors:
Stefan Berger

Prog Nucl Magn Reson Spectrosc 2018 Oct 28;108:74-114. Epub 2018 Nov 28.

Institute of Analytical Chemistry, University Leipzig, Johannisallee 29, D-04103 Leipzig, Germany. Electronic address:

SERF, an NMR pulse sequence for selectively measuring a spin coupling constant without interference from other couplings, was published by the current author almost 25 years ago in 1995. Since then, about 35 modifications and extensions of the original have been published by other groups and applied to many chemical problems. This review discusses these modifications and provides pertinent examples. Read More

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October 2018

MR approaches in neurodegenerative disorders.

Authors:
Andrew M Blamire

Prog Nucl Magn Reson Spectrosc 2018 Oct 3;108:1-16. Epub 2018 Nov 3.

Institute of Cellular Medicine and Centre for In Vivo Imaging, Newcastle University, UK. Electronic address:

Neurodegenerative disease is the umbrella term which refers to a range of clinical conditions causing degeneration of neurons within the central nervous system leading to loss of brain function and eventual death. The most prevalent of these is Alzheimer's disease (AD), which affects approximately 50 million people worldwide and is predicted to reach 75 million by 2030. Neurodegenerative diseases can only be fully diagnosed at post mortem by neuropathological assessment of the type and distribution of protein deposits which characterise each different condition, but there is a clear role for imaging technologies in aiding patient diagnoses in life. Read More

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October 2018

Application of atomic force microscopy in cancer research.

J Nanobiotechnology 2018 Dec 11;16(1):102. Epub 2018 Dec 11.

The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health and Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, China.

Atomic force microscopy (AFM) allows for nanometer-scale investigation of cells and molecules. Recent advances have enabled its application in cancer research and diagnosis. The physicochemical properties of live cells undergo changes when their physiological conditions are altered. Read More

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December 2018

Use of thioglycerol on porous polyurethane as an effective theranostic capping agent for bone tissue engineering.

J Biomater Appl 2018 Dec 11:885328218817173. Epub 2018 Dec 11.

Department of Materials Science and Engineering, Seoul National University, Seoul, Republic of Korea.

Thiolated biodegradable polyurethane (TG-DPU) was synthesized using a one-pot reaction with thioglycerol adopted as a functionalized chain extender. After characterization of the chemical structure of TG-DPU using proton nuclear magnetic resonance spectroscopy, bone morphogenetic protein (BMP-2) was loaded in the TG-DPU under oxidative conditions to form disulfides between the free thiol of TG-DPU and BMP-2. The interaction between TG-DPU and BMP-2, so-called bioconjugates, was investigated using X-ray photoelectron spectroscopy analysis; the appearance of disulfide (S-S) linkage indicated the formation of a polymer/growth factor conjugate system. Read More

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December 2018

Terahertz spectroscopy of individual carbon nanotube quantum dots.

Nano Lett 2018 Dec 12. Epub 2018 Dec 12.

We have investigated the electronic structures of metallic carbon nanotube quantum dots (CNT QDs) by terahertz-induced photocurrent spectroscopy. Sharp peaks due to intersublevel transitions in the CNT QDs are observed at the sublevel energy spacings expected from the linear band dispersion. The linewidth of the photocurrent peak is as narrow as 0. Read More

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December 2018

High Hole Mobility and Nonsaturating Giant Magnetoresistance in the New 2D Metal NaCu4Se4 Synthesized by a Unique Pathway.

J Am Chem Soc 2018 Dec 11. Epub 2018 Dec 11.

The new compound NaCu4Se4 forms by the reaction of CuO and Cu in a molten sodium polyselenide flux, with the existence of CuO being unexpectedly critical to its synthesis. It adopts a layered hexagonal structure (space group P63/mmc with cell parameters a = 3.9931(6) Å and c = 25. Read More

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December 2018
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