1,693 results match your criteria Speckled Lentiginous Nevus


Sp140 is a multi-SUMO-1 target and its PHD finger promotes SUMOylation of the adjacent Bromodomain.

Biochim Biophys Acta Gen Subj 2018 Nov 19. Epub 2018 Nov 19.

Biomolecular NMR Unit c/o IRCCS S. Raffaele, Via Olgettina 58, 20132 Milano, Italy. Electronic address:

Background: Human Sp140 protein is a leukocyte-specific member of the speckled protein (Sp) family (Sp100, Sp110, Sp140, Sp140L), a class of multi-domain nuclear proteins involved in intrinsic immunity and transcriptional regulation. Sp140 regulates macrophage transcriptional program and is implicated in several haematologic malignancies. Little is known about Sp140 structural domains and its post-translational modifications. Read More

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November 2018

Mixed connective tissue disease complicated by heart failure in Ile-Ife, Nigeria: management challenges in a resource-limited economy.

Int Med Case Rep J 2018 2;11:307-312. Epub 2018 Nov 2.

Department of Cardiology,

Background: Mixed connective tissue disease (MCTD; also known as Sharp's syndrome) is a rare autoimmune inflammatory disorder characterized by high titer of U1 ribonucleoprotein (U1RNP) antibody and clinical and serological overlap of systemic lupus erythematosus, systemic sclerosis, and polymyositis. The diagnosis is based on clinical and serological factors in criteria such as Alarcon-Segovia, Khan, Kusakawa, and Sharps. Cardiac disease can be a complication of connective tissue disease (CTD). Read More

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November 2018
5 Reads

Dinosaur egg colour had a single evolutionary origin.

Nature 2018 Nov 31;563(7732):555-558. Epub 2018 Oct 31.

Division of Vertebrate Paleontology, American Museum of Natural History, New York, NY, USA.

Birds are the only living amniotes with coloured eggs, which have long been considered to be an avian innovation. A recent study has demonstrated the presence of both red-brown protoporphyrin IX and blue-green biliverdin-the pigments responsible for all the variation in avian egg colour-in fossilized eggshell of a nonavian dinosaur. This raises the fundamental question of whether modern birds inherited egg colour from their nonavian dinosaur ancestors, or whether egg colour evolved independently multiple times. Read More

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November 2018
13 Reads

Initial presentation determines clinical entity in patients with anti-centromere antibody positivity.

Int J Rheum Dis 2018 Nov 14. Epub 2018 Nov 14.

Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.

Aim: Anti-centromere antibody (ACA) is often detected in patients with autoimmune diseases, including limited cutaneous systemic sclerosis (SSc), Sjögren's syndrome (SS), and primary biliary cholangitis (PBC). The association between autoimmune disease and ACA positivity remains unclear. We sought to clarify the clinical features of ACA-positive patients and their association with autoantibodies. Read More

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November 2018
2 Reads

Ventricular-subventricular zone fractones are speckled basement membranes that function as a neural stem cell niche.

Mol Biol Cell 2018 Oct 31:mbcE18050286. Epub 2018 Oct 31.

Laboratory of Extracellular Matrix Biochemistry, Institute for Protein Research, Osaka University, Suita, Osaka 565-0871, Japan.

Neural stem cells (NSCs) are retained in the adult ventricular-subventricular zone (V-SVZ), a specialized neurogenic niche with a unique cellular architecture. It currently remains unclear whether or how NSCs utilize basement membranes (BMs) in the niche. Here, we examined the molecular compositions and functions of BMs in the adult mouse V-SVZ. Read More

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October 2018
5 Reads

Seventeen New Cases of Chronic Ulcerative Stomatitis with Literature Review.

Head Neck Pathol 2018 Oct 29. Epub 2018 Oct 29.

College of Dentistry, University of Florida, Gainesville, FL, USA.

Chronic ulcerative stomatitis (CUS) is a poorly understood disease with clinical and histologic overlap with lichen planus (LP). Unlike classic LP, direct immunofluorescence (DIF) studies in cases of CUS exhibit a granular pattern of IgG in nuclei of basal and parabasal cells. This study assesses the demographic, clinical, histologic, and DIF features of CUS. Read More

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October 2018
2 Reads

On the influence of surface coating on tissue biomechanics - effects on rat bones under routine conditions with implications for image-based deformation detection.

BMC Musculoskelet Disord 2018 Oct 27;19(1):387. Epub 2018 Oct 27.

Department of Anatomy, University of Otago, Lindo Ferguson Building, 270 Great King St, Dunedin, 9016, New Zealand.

Background: Biomechanical testing using image-based deformation detection techniques such as digital image correlation (DIC) offer optical contactless methods for strain and displacement measurements of biological tissues. However, given the need of most samples to be speckled for image correlation using sprays, chemical alterations with impact on tissue mechanicals may result. The aim of this study was to assess the impact of such surface coating on the mechanical properties of rat bones, under routine laboratory conditions including multiple freeze-thaw cycles. Read More

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October 2018

Relationships among Antibodies against Extractable Nuclear Antigens, Antinuclear Antibodies, and Autoimmune Diseases in a Brazilian Public Hospital.

Autoimmune Dis 2018 30;2018:9856910. Epub 2018 Sep 30.

Laboratory of Applied Immunology, Center of Medical and Pharmaceutical Sciences, Western Parana State University, Cascavel/PR 85819-110, Brazil.

One characteristic of autoimmune diseases (ADs) is the production of autoantibodies for extractable nuclear autoantigens, which may aid in the discrimination of the different types of autoimmune diseases and is related to different antinuclear antibody (ANA) patterns. The present study verified the profile of patient samples tested for extractable nuclear antigens (ENA) antibodies in a public hospital and correlated the ENA results with ANA patterns and patient diagnoses. The study reviewed data in the medical records of patients who underwent anti-ENA tests at a public hospital in the West of the State of Paraná from February 2011 to January 2017. Read More

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September 2018
1 Read

SPECKLED HYPOAUTOFLUORESCENCE AS A SIGN OF RESOLVED SUBRETINAL HEMORRHAGE IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION.

Retina 2018 Oct 22. Epub 2018 Oct 22.

Vitreous Retina Macula Consultants of New York, New York, New York.

Purpose: To describe patterns of hypoautofluorescence in eyes with neovascular age-related macular degeneration occurring after subretinal hemorrhage.

Methods: This was a retrospective descriptive analysis of neovascular age-related macular degeneration eyes presenting with subretinal hemorrhage over the last 5 years that underwent serial multimodal imaging. A review of color fundus photographs, fundus autofluorescence, near-infrared reflectance, and optical coherence tomography was performed at baseline and all available follow-up visits to document the course and evolution of subretinal hemorrhage in these eyes. Read More

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October 2018
5 Reads

Phantom Nodules Detected by Ultrasound Examination of the Neck: The Possibility of Ectopic Cervical Thymic Tissue in Adults.

Ultrasound Int Open 2018 Oct 19;4(4):E119-E123. Epub 2018 Oct 19.

Kuma Hospital, Department of Surgery, Kobe, Japan.

Purpose: The aim of this study was to investigate the ultrasound characteristics and clinical significance of slightly hyperechoic lesions, referred to as phantom nodules, in the perithyroidal area in patients.

Materials And Methods: A total of 128 patients who underwent thyroidectomy with central neck lymph node dissection at Kuma Hospital in Hyogo, Japan were included in the study. We detected 16 phantom nodules during preoperative ultrasound examinations, defined as slightly hyperechoic masses located in the perithyroidal areas, in 13 of these 128 patients (10. Read More

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October 2018
6 Reads

SLE in a Male Patient Presented Initially as Rowell's Syndrome.

J Assoc Physicians India 2018 Jan;66(1):98-99

Professor, Department of Tropical Medicine, School of Tropical Medicine, Kolkata, West Bengal.

A 22 year old male Indian patient presented with high grade fever, multiple joint pain, low back pain, generalized body ache since 6 months and erythematous pruritic rashes and atypical annular target like lesions over face, arm, leg and back and ulcers on hard palate and buccal mucosa for 2 months. Laboratory investigations showed a speckled pattern anti-nuclear antibody with a titer >1:160 and positive SS-A, dsDNA auto-antibodies and Rheumatoid factor. Diagnosis of Rowell's syndrome was made based on clinical and laboratory finding and the patient was treated with oral prednisolone (50 mg/day), hydroxychloroquine (200 mg q12h) and pulse cyclophosphamide (700 mg) chemotherapy. Read More

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January 2018
5 Reads

Spatio-temporal and risk factor analysis of alleles related to Scrapie resistance in sheep in Great Britain before, during and after a national breeding program.

Prev Vet Med 2018 Nov 23;159:12-21. Epub 2018 Aug 23.

Department of Epidemiological Sciences, Animal and Plant Health Agency (APHA-Weybridge), Woodham Lane, New Haw, Addlestone, Surrey, KT15 3NB, UK.

Certain genotypes of sheep have been identified to increase their susceptibility (the VRQ allele) or resistance (the ARR allele) to classical scrapie. This study's aim was to assess the spatio-temporal pattern of the ARR and VRQ alleles in Great Britain (GB) and to explore the risk factors associated to their presence. Data was collected from the GB scrapie active surveillance program, the sheep and goat inventory survey (GB census survey) and the agricultural survey for the period 2002-2015. Read More

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November 2018
1 Read

High-frequency vocalizations in Andean hummingbirds.

Curr Biol 2018 Sep;28(17):R927-R928

Neuroscience Institute, Center for Behavioral Neuroscience, Georgia State University, Atlanta, GA 30302, USA.

Hummingbirds possess a number of unique features. A recent report in Current Biology[1] showed that the Black Jacobin (Florisuga fusca), a Brazilian hummingbird in the Topazes clade, produces high-frequency vocalizations outside the known hearing range of birds. Here, we report that four hummingbird species in the Andean clade [2,3] also exhibit high-frequency vocalizations: the Ecuadorian Hillstar (Oreotrochilus chimborazo), with the highest fundamental frequency (mean F0 = 13. Read More

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September 2018

Estimation of additive and non-additive genetic variances of body weight in crossbreed populations of the Japanese quail.

Poult Sci 2018 Aug 30. Epub 2018 Aug 30.

Animal breeding, Department of Animal Science, Faculty of Agriculture,and Department of Bioinformatics, University of Zabol, Zabol 9861335856, Iran.

A major part of the growth performance in birds is the result of the combined effects of genes, including the general and specific combining ability that requires the design of an optimal mating system. The aim of this study was to fit the best model for each body weight trait from hatch to 45 days and the estimation of the variance components and the genetic parameters for the body weight traits of a crossbred population. This crossbred population was created by 4 strains of Japanese quail, including the Italian Speckled (A), Tuxedo (B), Pharaoh (C), A&M Texas (D), and the body weights of the different combinations were analyzed by 24 models including the direct genetic effect, the non-additive genetic effects including dominance and epistatic effects, the maternal permanent environmental and maternal genetic effects. Read More

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[Analyses of pathogenic factors and clinicopathological characteristics of vocal leukoplakia].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Aug;53(8):581-586

Department of Otorhinolaryngology Head and Neck Surgery, Peking University People's Hospital, Beijing 100044, China.

To investigate the pathogenic factors of vocal leukoplakia and its clinical and pathological features. Eighty-one patients with vocal cord leukoplakia who underwent surgery between February 2010 and December 2016 and 160 volunteers without pharyngeal symptoms designed as controls were included in this case control study. The clinicopathological characteristics of 81 patients were summarized and analyzed synthetically. Read More

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August 2018
13 Reads

Aberration recovery by imaging a weak diffuser.

Opt Express 2018 Aug;26(16):21054-21068

We present a computational method for field-varying aberration recovery in optical systems by imaging a weak (index-matched) diffuser. Using multiple images acquired under plane wave illumination at distinct angles, the aberrations of the imaging system can be uniquely determined up to a sign. Our method is based on a statistical model for image formation that relates the spectrum of the speckled intensity image to the local aberrations at different locations in the field-of-view. Read More

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August 2018
10 Reads

The effect of kidney transplantation on speckled tracking echocardiography findings in patients on hemodialysis.

J Cardiovasc Thorac Res 2018 29;10(2):90-94. Epub 2018 Jun 29.

Cardiovascular Research Center, Department of Cardiovascular Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Cardiac dysfunction is a major cause of morbidity and mortality in patients with end-stage renal disease (ESRD). Previous studies have shown that kidney transplantation can reverse some of the gross changes in the myocardial structure such as left ventricular ejection fraction (LVEF) and volumes. Whether kidney transplantation can reverse the subtle and early myocardial changes in ESRD patients who do not suffer from gross alternations in myocardial function is not yet studied. Read More

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June 2018
7 Reads

Nonmeasurable Speckled Contrast-Enhancing Lesions Appearing During Course of Disease Are Associated With IDH Mutation in High-Grade Astrocytoma Patients.

Int J Radiat Oncol Biol Phys 2018 Jul 31. Epub 2018 Jul 31.

Department of Neurology and Neurooncology Program, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany. Electronic address:

Purpose: Because treatment options at progression are limited for patients with glioma, accuracy in definition of progression is pivotal. Clinically asymptomatic, newly detected, nonmeasurable, speckled contrast-enhancing lesions (SCEs) without immediate relation to prior immune therapy or radiation therapy appear relatively frequently during the course of disease in patients with glioma and challenge the definition of progression based on Response Assessment in Neuro-oncology criteria. Therefore, data characterizing these SCEs are needed for recommendations of subsequent clinical management. Read More

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July 2018
1 Read

A Spectrum of Neural Autoantigens, Newly Identified by Histo-Immunoprecipitation, Mass Spectrometry, and Recombinant Cell-Based Indirect Immunofluorescence.

Front Immunol 2018 9;9:1447. Epub 2018 Jul 9.

Institute of Experimental Immunology, EUROIMMUN AG, Lübeck, Germany.

Background: A plurality of neurological syndromes is associated with autoantibodies against neural antigens relevant for diagnosis and therapy. Identification of these antigens is crucial to understand the pathogenesis and to develop specific immunoassays. Using an indirect immunofluorescence assay (IFA)-based approach and applying different immunoprecipitation (IP), chromatographic and mass spectrometric protocols was possible to isolate and identify a spectrum of autoantigens from brain tissue. Read More

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July 2018
1 Read

The clinical significance of borderline results of the Elia CTD Screen assay.

Clin Chem Lab Med 2018 Nov;56(12):2088-2092

Department of Psychiatry, General Hospital Southwest, Graz, Austria.

Background Data on the clinical relevance of borderline results of solid-phase assays in the screening for antinuclear antibodies (ANA) are sparse. This study aimed to determine the clinical significance of borderline results of the Elia CTD Screen (ECS; Phadia/Thermo Fisher Scientific, Freiburg, Germany), a fluoroenzymeimmunoassay incorporating 17 recombinant human nuclear antigens. Methods We retrospectively examined the medical records of 143 subjects with borderline ECS results for ANA-associated autoimmune disorders (AASARD) and the association with the results of indirect immunofluorescence (IIF) and confirmatory assays for ANA. Read More

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November 2018
7 Reads

Antinuclear antibodies detection: A comparative study between automated recognition and conventional visual interpretation.

J Clin Lab Anal 2018 Jul 20:e22619. Epub 2018 Jul 20.

Department of Clinical Laboratory, Peking University First Hospital, Beijing, China.

Background: The indirect immunofluorescence assay (IIFA) for the detection of antinuclear antibodies (ANA) was firstly described in 1958 and is still considered the reference method for ANA screening. Currently, an automated processing and recognition system for standardized and efficient ANA interpretation by human epithelial (HEp-2) cell-based immunofluorescence (IIF; EUROPattern Suite, Euroimmun) is available in China.

Methods: In this study, the performance of this novel system for positive/negative classification, pattern recognition (including homogenous, speckled, nucleolar, nuclear dots, cytoplasmic, and centromeres patterns) and titers evaluation was evaluated by comparing to visual interpretation. Read More

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Introgression of regulatory alleles and a missense coding mutation drive plumage pattern diversity in the rock pigeon.

Elife 2018 07 17;7. Epub 2018 Jul 17.

School of Biological Sciences, University of Utah, Salt Lake City, United States.

Birds and other vertebrates display stunning variation in pigmentation patterning, yet the genes controlling this diversity remain largely unknown. Rock pigeons () are fundamentally one of four color pattern phenotypes, in decreasing order of melanism: T-check, checker, bar (ancestral), or barless. Using whole-genome scans, we identified as a candidate gene for this variation. Read More

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July 2018
11 Reads

Towards a practical implementation of X-ray ghost imaging with synchrotron light.

IUCrJ 2018 Jul 7;5(Pt 4):428-438. Epub 2018 Jun 7.

School of Physics and Astronomy, Monash University, Victoria 3800, Australia.

An experimental procedure for transmission X-ray ghost imaging using synchrotron light is presented. Hard X-rays from an undulator were divided by a beamsplitter to produce two copies of a speckled incident beam. Both beams were simultaneously measured on an indirect pixellated detector and the intensity correlation between the two copies was used to retrieve the ghost image of samples placed in one of the two beams, without measuring the samples directly. Read More

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Atypical Nevi in a Patient After Toxic Epidermal Necrolysis.

Acta Dermatovenerol Croat 2018 Jun;26(2):183-185

Ružica Jurakić Tončić, MD, Department of Dermatovenereology, University Hospital Centre Zagreb, University of Zagreb School of Medicine, Šalata 4, 10000 Zagreb, Croatia;

Dear Editor, There are few literature data about nevi in patients with a history of toxic epidermal necrolysis (TEN) and little recommendations for follow-up and risks of melanoma (MM). Eruptive melanocytic nevi (EMN) is a rare phenomenon that has been associated with bullous disorders, immunosuppression, and immunodeficiency, but in some cases can occur without precipitating factors (1). The etiology is largely unknown, but there is evidence that immunosuppression might play a crucial role in nevogenesis, probably due to the inability of the immune system to inhibit melanocytic (MC) proliferation (2,3). Read More

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June 2018
10 Reads

Torsion of Ovarian Dysgerminoma in a Child: Role of Computed Tomography.

Cureus 2018 Apr 23;10(4):e2522. Epub 2018 Apr 23.

Department of Pathology & Laboratory Medicine, The Aga Khan University, Karachi, PAK.

Dysgerminomas are malignant germ cell tumors of the ovary that most commonly occur in the adolescent population. Ovarian dysgerminoma presenting with complications like torsion is a rare entity in the pediatric age group. Cross-sectional imaging plays a crucial role in diagnosis, tumor staging before surgical resection, and for planning adjuvant chemotherapy. Read More

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April 2018
2 Reads

Antinuclear antibodies in scrub typhus: Transient occurrence during acute illness.

J Vector Borne Dis 2018 Jan-Mar;55(1):52-57

Department of Critical Care, Christian Medical College & Vellore, India.

Background & Objectives: The pathological hallmark of scrub typhus infection is focal or disseminated vasculitis. As with other infections, antinuclear antibodies (ANA) have been previously described in scrub typhus. However, the underlying mechanisms and implications of this immunological phenomenon is not well understood. Read More

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October 2018
15 Reads

Acral speckled hypomelanosis: a novel dermatosis.

Clin Exp Dermatol 2018 Dec 28;43(8):955-957. Epub 2018 May 28.

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research (PGIIMER), Sector 12, Chandigarh, 160012, India.

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December 2018

Case Report: Hydroxychloroquine Retinopathy.

Optom Vis Sci 2018 Jun;95(6):545-549

Montreal Retina Institute, Montreal, Quebec, Canada.

Significance: Hydroxychloroquine retinopathy causes irreversible central visual loss and can progress despite medication discontinuation. Appropriate dosing and recognition of early disease are important to minimize adverse visual sequelae. In 2016, the American Academy of Ophthalmology updated its 2011 recommendations for dosing, screening, and monitoring of hydroxychloroquine retinopathy. Read More

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June 2018
1 Read

New genetically engineered DFS70 knock-out HEp-2 cells enable rapid and specific recognition of anti-DFS70 antibodies.

Autoimmunity 2018 Jun 6;51(4):152-156. Epub 2018 May 6.

b Azienda Sanitaria Universitaria Integrata , Udine , Italy.

Background: The correct identification of anti-dense fine speckled-70 (DFS70) antibodies represents an important issue in the detection of anti-nuclear antibodies (ANAs) as performed by the indirect immunofluorescence (IIF) test on HEp-2 substrates. In this study, we have evaluated a new method for anti-DFS70 antibody detection employing HEp-2 cells knocked-out for the DFS70 antigen.

Methods: We studied 148 sera with a DFS70-like pattern (91 positive and 57 negative when tested for anti-DFS70 antibodies by a specific chemoluminescence [CLIA] method); 116 sera with infectious disease; 100 healthy donors (HDs), 139 samples from patients with a defined diagnosis of autoimmune rheumatic disease (ARD), and 242 consecutive unselected samples screened for ANA during the routine work-up. Read More

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June 2018
12 Reads

Thyroid Nodules in Pediatric Patients: Sonographic Characteristics and Likelihood of Cancer.

Radiology 2018 08 1;288(2):591-599. Epub 2018 May 1.

From the Department of Radiology, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115 (D.M.R., C.B.B., P.M.D., H.E.P., E.A., M.C.F.); and Thyroid Program, Division of Endocrinology, Boston Children's Hospital, Boston, Mass (S.A.H., A.J.W., J.R.S., C.E.C.).

Purpose To determine the relationship between demographic and sonographic characteristics of thyroid nodules and malignancy in a pediatric population. Materials and Methods All thyroid nodules in patients younger than 19 years that underwent ultrasound (US)-guided fine-needle aspiration biopsy between January 2004 and July 2017 were retrospectively identified. Age, sex, and background appearance of the thyroid gland were recorded for each patient, and sonographic characteristics and pathologic diagnosis were recorded for each nodule. Read More

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August 2018
6 Reads

Diagnostic utility of automated indirect immunofluorescence compared to manual indirect immunofluorescence for anti-nuclear antibodies in patients with systemic rheumatic diseases: A systematic review and meta-analysis.

Semin Arthritis Rheum 2018 Mar 27. Epub 2018 Mar 27.

Department of Laboratory Medicine, Cancer Research Institute, Kosin University College of Medicine, Gamcheon-ro 262, Seo-gu, Busan 49267, Republic of Korea. Electronic address:

Objective: This study aimed to review and compare the analytical and clinical performance of automated indirect immunofluorescence (AIIF) and manual indirect immunofluorescence (MIIF) as anti-nuclear antibody screening assays for patients with systemic rheumatic diseases (SRDs), such as systemic lupus erythematosus (SLE) and systemic sclerosis (SSc).

Methods: A systematic literature search was performed in the Medline, Embase, Cochrane, Web of Science, and Scopus databases for studies published before August 2017. A bivariate random effects model was used to calculate the summary diagnostic values. Read More

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March 2018
6 Reads

Molecular systematics of the North American chub genus Macrhybopsis (Teleostei: Cyprinidae).

Zootaxa 2018 Jan 25;4375(4):537-554. Epub 2018 Jan 25.

Department of Integrative Biology, Oklahoma State University, Stillwater, Oklahoma, 74078 USA..

The North American fish genus Macrhybopsis (Teleostei: Cyprinidae) as presently conceived comprises 12 species and occurs in much of interior eastern North America. Variation in the mitochondrial ND2 gene and the nuclear S7 intron 1 reveal conflicting gene-tree relationships for deeper nodes, which are assumed to represent past introgression and heterospecific mitochondrial fixation. The results support monophyly for the wide-ranging M. Read More

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January 2018

Recognition and Relevance of Anti-DFS70 Autoantibodies in Routine Antinuclear Autoantibodies Testing at a Community Hospital.

Front Med (Lausanne) 2018 9;5:88. Epub 2018 Apr 9.

Lexington Medical Center, West Columbia, SC, United States.

Antinuclear autoantibodies (ANA) displaying a dense fine speckled pattern (DFS, ICAP AC-2) on HEp-2 cells are frequently observed in clinical laboratory referrals, often associated with anti-DFS70 specificity. Anti-DFS70 positive patients rarely develop systemic autoimmune rheumatic disease (SARD), especially in the absence of clinical evidence or additional anti-extractable nuclear antigen (ENA) antibodies, prompting suggestions that an isolated DFS70-specific ENA may be an exclusionary finding for SARD. In this study, the frequency and diagnostic significance of anti-DFS70 autoantibodies was investigated in a community hospital cohort of patients undergoing routine ANA testing. Read More

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April 2018
3 Reads

Dermoscopic features of onychotillomania: A study of 36 cases.

J Am Acad Dermatol 2018 Oct 14;79(4):702-705. Epub 2018 Apr 14.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida.

Background: Onychotillomania is a nail-picking disorder characterized by nail dystrophy and abnormal morphology of the nail plate, nail bed, and periungual skin.

Objective: The purpose of this study was to describe the dermoscopic features of onychotillomania.

Methods: A retrospective study of the dermoscopy images of 36 patients affected by onychotillomania. Read More

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October 2018
7 Reads

Anti-nuclear antibodies in patients with breast cancer.

Clin Exp Immunol 2018 Aug 14;193(2):178-182. Epub 2018 Jun 14.

Medicine Department, Evangelical University, Curitiba, Brazil.

To study the prevalence of anti-nuclear antibodies (ANA) in breast cancer patients and its association with tumour characteristics. Ninety-one patients with breast mass detected by image studies and assigned to conduct diagnostic biopsy and eventual surgical treatment were studied for demographical, tumour data and presence of ANA. Serum of positive ANA patients was screened for the extractable nuclear antigen (ENA) profile. Read More

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Case Report: Dermoscopic features of oral lichen planus - the evolution of mucoscopy.

F1000Res 2018 6;7:284. Epub 2018 Mar 6.

Department of Dermatology, College of Medicine, King Faisal University, Hofuf, Saudi Arabia.

Dermoscopy, a non-invasive technique for cutaneous diagnosis is being increasingly studied in various disorders of the skin, nails and scalp. However, it has been under-utilized for the diagnosis and characterization of mucosal disorders. The dermoscopic characterization of cutaneous lichen planus and its variants has been well documented with Wickham's striae constituting the hallmark of the condition. Read More

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March 2018
14 Reads

Anti-DFS70 autoantibodies in undifferentiated connective tissue diseases subjects: what's on the horizon?

Rheumatology (Oxford) 2018 Apr 3. Epub 2018 Apr 3.

Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Aviv, Israel.

Objective: The main objective was to determine the prevalence of anti-dense fine speckled (DFS70) antibodies in a stable population of undifferentiated connective tissue disease (UCTD) to better define their potential role.

Methods: Immunological and clinical records of 91 long-standing UCTD patients were studied. DFS pattern was determined using the IIF ANA test on HEp-2 cells and anti-DFS70 antibodies were tested by chemiluminescence assay and by DFS70 line immunoassay. Read More

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April 2018
19 Reads

Paraganglioma: Cytomorphologic features, radiologic and clinical findings in 12 cases.

Diagn Cytopathol 2018 Jun 25;46(6):473-481. Epub 2018 Mar 25.

Department of Pathology, Division of Cytopathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.

Background: The cytologic diagnosis of paraganglioma can be challenging because of its rarity, wide anatomic distribution, and variable cytomorphological features.

Design: The Johns Hopkins Hospital pathology archives were searched for fine-needle aspiration (FNA) specimens confirmed as paraganglioma on histology (2003-2015).

Results: Twelve specimens from 10 patients (6 males and 4 females) with an age range of 16-81 years (mean = 47) were included. Read More

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June 2018
1 Read

Speckled lentiginous nevus: A rare presentation associated with motor neuropathy and muscular atrophy in a child.

Pediatr Dermatol 2018 May 24;35(3):e161-e162. Epub 2018 Mar 24.

Southern California Permanente Medical Group, Pasadena, CA, USA.

Speckled lentiginous nevus syndrome has been described in individuals with a speckled lentiginous nevus with rare associated neurologic deficits. Because speckled lentiginous nevus syndrome almost always affects adults, it is not typically considered when evaluating children. We present the first reported case of speckled lentiginous nevus syndrome presenting in a young child with muscle atrophy and motor deficits affecting muscles along the same distribution as the speckled lentiginous nevus. Read More

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May 2018
8 Reads

ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease.

Sci Rep 2018 Mar 19;8(1):4852. Epub 2018 Mar 19.

Department of Clinical Sciences, Swedish University of Agricultural Sciences, SE-750 07, Uppsala, Sweden.

Dogs can spontaneously develop complex systemic autoimmune disorders, with similarities to human autoimmune disease. Autoantibodies directed at self-antigens are a key feature of these autoimmune diseases. Here we report the identification of interleukin enhancer-binding factors 2 and 3 (ILF2 and ILF3) as autoantigens in canine immune-mediated rheumatic disease. Read More

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March 2018
2 Reads
5.080 Impact Factor

Clinical and imaging features of Kaposiform Hemangioendothelioma.

Br J Radiol 2018 Jun 20;91(1086):20170798. Epub 2018 Mar 20.

3 Department of Radiology, Fudan University Shanghai Cancer Center , Shanghai , China.

Objective: Kaposiform hemangioendothelioma (KHE) is a unique locally aggressive vascular tumor with poor prognosis. The aim of this study is to assess the clinical and imaging features of KHE, and to compare the differences between solitary and diffusive infiltrative subtype further.

Methods: The clinical and radiological findings of a cohort of 25 cases with histologically proven KHE, between June 2011 and June 2016, were reviewed retrospectively. Read More

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June 2018
3 Reads

De novo hotspot variants in CYFIP2 cause early-onset epileptic encephalopathy.

Ann Neurol 2018 Apr;83(4):794-806

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Objective: The cytoplasmic fragile X mental retardation 1 interacting proteins 2 (CYFIP2) is a component of the WASP-family verprolin-homologous protein (WAVE) regulatory complex, which is involved in actin dynamics. An obvious association of CYFIP2 variants with human neurological disorders has never been reported. Here, we identified de novo hotspot CYFIP2 variants in neurodevelopmental disorders and explore the possible involvement of the CYFIP2 mutants in the WAVE signaling pathway. Read More

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April 2018
6 Reads

Ultrasound Imaging From Sparse RF Samples Using System Point Spread Functions.

IEEE Trans Ultrason Ferroelectr Freq Control 2018 Mar;65(3):316-326

Upcoming phased-array 2-D sensors will soon enable fast high-definition 3-D ultrasound imaging. Currently, the communication of raw radio-frequency (RF) channel data from the probe to the computer for digital beamforming is a bottleneck. For reducing the amount of transferred data samples, this paper investigates the design of an adapted sparse sampling technique for image reconstruction inspired by the compressed sensing framework. Read More

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March 2018
2 Reads

Origins and specificity of auto-antibodies in Sm+ SLE patients.

J Autoimmun 2018 Jun 1;90:94-104. Epub 2018 Mar 1.

Gwen Knapp Center for Lupus and Immunology Research, Department of Pathology, University of Chicago, Chicago, IL, 60637, USA.

Systemic lupus erythematosus (SLE) is a complex autoimmune disease accompanied by production of autoantibodies directed to a variety of self-proteins and nucleic acids. The genetic basis of SLE is also complex with at least 40 susceptibility loci identified. This complexity suggests that there are a variety of SLE manifestations; nevertheless, SLE is treated as a single disease clinically. Read More

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June 2018
4 Reads

Agent-based computational models to explore diffusion of medical innovations among cardiologists.

Int J Med Inform 2018 Apr 10;112:158-165. Epub 2018 Feb 10.

Health Economics and Technology Assessment Unit, Medical Education and Clinical Investigation Center (CEMIC) University Institute, Argentina.

Background: Diffusion of medical innovations among physicians rests on a set of theoretical assumptions, including learning and decision-making under uncertainty, social-normative pressures, medical expert knowledge, competitive concerns, network performance effects, professional autonomy or individualism and scientific evidence.

Objectives: The aim of this study was to develop and test four real data-based, agent-based computational models (ABM) to qualitatively and quantitatively explore the factors associated with diffusion and application of innovations among cardiologists.

Methods: Four ABM were developed to study diffusion and application of medical innovations among cardiologists, considering physicians' network connections, leaders' opinions, "adopters' categories", physicians' autonomy, scientific evidence, patients' pressure, affordability for the end-user population, and promotion from companies. Read More

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April 2018
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Thermodynamic compatibility and interactions between Speckled Sugar bean protein and xanthan gum for production of multilayer O/W emulsion.

J Food Sci Technol 2018 Mar 25;55(3):1143-1153. Epub 2018 Jan 25.

Department of Food Nanotechnology, Research Institute of Food Science and Technology, Mashhad, Iran.

Thermodynamic compatibility and probable interactions between Speckled Sugar been protein (SSBP) and xanthan gum for production of multilayer O/W emulsion (30% oil) were investigated. Different interactions were observed between SSBP and xanthan at different pH (3-7) including electrostatic interactions and hydrogen bonding. These interactions were predominant at pH 3. Read More

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March 2018
2 Reads

Case of combined nevus showing a speckled distribution pattern.

J Dermatol 2018 Aug 22;45(8):e232-e233. Epub 2018 Feb 22.

Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan.

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August 2018
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Desmoplastic transformation of a nodular melanoma arising from a speckled lentiginous nevus.

J Dermatol 2018 Aug 21;45(8):e230-e231. Epub 2018 Feb 21.

Department of Plastic and Reconstructive Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

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August 2018
3 Reads

Drug-induced Rowell syndrome, a rare and difficult to manage disease: A case report.

Exp Ther Med 2018 Jan 23;15(1):785-788. Epub 2017 Nov 23.

Department of Ophthalmology, Grigore T. Popa University of Medicine and Pharmacy, 700715 Iași, Romania.

Rowell syndrome is defined as the association between lupus erythematosus, erythema multiforme-like lesions and characteristic immunological changes including positive tests for rheumatoid factor, speckled antinuclear antibody, positive anti-Ro or anti-La antibodies. The present report presents the case of a 45-year-old female patient who was previously diagnosed in January 2010 with terbinafine-induced subacute cutaneous lupus erythematosus and was admitted for a skin eruption consisting of erythematous-papular erythema multiforme-like lesions, primarily on the trunk and limbs. The associated symptoms consisted of fatigability, myalgia and gonalgia. Read More

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January 2018
7 Reads

Phacomatosis pigmentokeratotica: a case of HRAS mosaicism causing rhabdomyosarcoma.

Br J Dermatol 2018 Nov 9;179(5):1163-1167. Epub 2018 May 9.

Department of Pathology, Hospital Universitario 12 de Octubre, I+12 Research Institute, Universidad Complutense, Madrid, Spain.

A 17-year-old male presented with a large sebaceous naevus (SN) comprising part of his right face and scalp and a speckled lentiginous naevus (SLN) on his left trunk, hip, neck and scalp with a checkerboard pattern. His right oral hemimucosa showed extensive papillomatous lesions, which were contiguous with the upper-lip SN lesions. He also showed extracutaneous manifestations including cardiac, musculoskeletal and ocular alterations. Read More

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November 2018
1 Read