2,609 results match your criteria Spasmodic Dysphonia

Effects of nerol on paracetamol-induced liver damage in Wistar albino rats.

Biomed Pharmacother 2021 Jun 12;140:111732. Epub 2021 Jun 12.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Nerol, a monoterpene is evident to possess diverse biological activities, including antioxidant, anti-microbial, anti-spasmodic, anthelmintic, and anti-arrhythmias. This study aims to evaluate its hepatoprotective effect against paracetamol-induced liver toxicity in a rat model. Five groups of rats (n = 7) were orally treated (once daily) with 0. Read More

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HNO 2021 Jun 14. Epub 2021 Jun 14.

Klinik für HNO-Heilkunde/Plastische Operationen, SRH Wald-Klinikum Gera, Straße des Friedens 122, 07548, Gera, Deutschland.

Neurological and neurophysiological knowledge of neuromuscular diseases is combined in neurolaryngology with experience from laryngology. Laryngeal electromyography (LEMG) is the most important diagnostic and prognostic tool in neurolaryngology. It can be combined with diagnostic electrostimulation. Read More

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Behavioral Therapy for Tremor or Dystonia Affecting Voice in Speakers with Hyperkinetic Dysarthria: A Systematic Review.

J Voice 2021 Jun 7. Epub 2021 Jun 7.

Department of Physical Medicine & Rehabilitation, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; Think + Speak Lab, Shirley Ryan AbilityLab, Chicago, Illinois.

Introduction: Hyperkinetic dysarthria is characterized by atypical involuntary movements within the speech mechanism that may affect the respiratory, laryngeal, pharyngeal-oral, or velopharyngeal-nasal subsystems and may alter speech production. Although articulatory impairments are commonly considered in hyperkinetic dysarthria, speakers with hyperkinetic dysarthria may also present with changes in voice quality, pitch, and loudness. In approximately 70% of speakers with hyperkinetic dysarthria, these voice alterations are associated with tremor or dystonia. Read More

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Deep Learning Application for Vocal Fold Disease Prediction Through Voice Recognition: Preliminary Development Study.

J Med Internet Res 2021 Jun 8;23(6):e25247. Epub 2021 Jun 8.

Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Background: Dysphonia influences the quality of life by interfering with communication. However, a laryngoscopic examination is expensive and not readily accessible in primary care units. Experienced laryngologists are required to achieve an accurate diagnosis. Read More

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Non-motor symptoms in spasmodic dysphonia: A case control-study.

Auris Nasus Larynx 2021 Jun 3. Epub 2021 Jun 3.

Institut d'Investigació Biomèdica Agustí Pi Sunyer (IDIBAPS), Barcelona, Spain; CIBERNED: CB06/05/0018-ISCIII, ERN-RND (ID No 739510), Barcelona, Spain; Parkinson's disease and Movement Disorders Unit, Neurology Service, Hospital Clinic Barcelona, Universitat de Barcelona.

Objective: Non-motor symptoms (NMS) have been identified in some focal adult-onset dystonia. In the present study we aimed to evaluate the presence of NMS in patients with spasmodic dysphonia (SD), a focal action-induced dystonia that affects intrinsic laryngeal muscle control.

Methods: Seventeen SD patients and 17 control subjects not significantly different in age and sex were evaluated for the presence of NMS. Read More

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Functional dystonia in the foot and ankle.

Bone Joint J 2021 Jun;103-B(6):1127-1132

Foot and Ankle Unit, The Royal National Orthopaedic Hospital, London, UK.

Aims: To assess the characteristic clinical features, management, and outcome of patients who present to orthopaedic surgeons with functional dystonia affecting the foot and ankle.

Methods: We carried out a retrospective search of our records from 2000 to 2019 of patients seen in our adult tertiary referral foot and ankle unit with a diagnosis of functional dystonia.

Results: A total of 29 patients were seen. Read More

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Anti-inflammatory, and Anti-arthritic Effects by the Twigs of Cinnamomum cassia on Complete Freund's Adjuvant-induced Arthritis in Rats.

J Ethnopharmacol 2021 May 17:114209. Epub 2021 May 17.

: Research Group of Pain and Neuroscience, East-West Medical Research Institute, WHO collaborating center, Kyung Hee University, Seoul 02447, Korea. Electronic address:

Ethnopharmacological Relevance: The young branches of C. cassia Blume (Cinnamomi Ramulus; Guizhi; ; C. cassia twigs) have long been used as an anti-pyretic, anti-rheumatic, anti-spasmodic and stomachic in traditional medicine. Read More

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[Summary on 's experience in clinical treatment of spasmodic torticollis].

Zhongguo Zhen Jiu 2021 May;41(5):537-40

Nanning Institute of Acupuncture and Moxibustion/Seventh People's Hospital of Nanning Municipal, Nanning 530012, Guangxi Zhuang Autonomous Region, China.

The thinking and experience of professor - in the treatment of spasmodic torticollis under the guidance of 's academic thoughts are introduced. In pathogenesis, spasmodic torticollis is related to the obstruction of circulation and malnutrition of tendons and vessels. "Promoting and benefiting " is considered as the main treating principle. Read More

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Does Intravenous Ondansetron Affect the Intestinal Motility Pattern in Healthy Donkeys (Equus asinus)?

J Equine Vet Sci 2021 Jun 25;101:103427. Epub 2021 Feb 25.

Department of Internal Medicine, Infectious and Fish Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt. Electronic address:

The current study was undertaken to investigate the effect of intravenous administration of ondansetron on the small and large intestinal motility in donkeys (Equus asinus) using non-invasive transabdominal ultrasonography. The current prospective, randomized, placebo-controlled, crossover study was conducted on thirty healthy donkeys (15 males and 15 females). The selected donkeys underwent two trials; the first was performed by intravenous administration of saline solution as a placebo, while the second was carried out by intravenous administration of ondansetron hydrochloride. Read More

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Effect of high frequency transcutaneous electrical nerve stimulation at root level menstrual pain in primary dysmenorrhea.

J Bodyw Mov Ther 2021 Apr 28;26:108-112. Epub 2020 Dec 28.

Department of Sports Science, Punjabi University, Patiala, India.

Introduction: Primary dysmenorrhea (PD) is a painful menstruation due to contractions in the uterus that induce ischemic pain associated with normal pelvic anatomy.

Objective: The purpose of the study is to evaluate the effect of High TENS application (root level) among adolescent girls of PD.

Methodology: 140 adolescent girls were included with 14-19 years of age and randomly allocated into two groups of Experimental and Control group. Read More

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Dynamic Study of Oesophageal Function during Phonation: Simple but Effective.

ORL J Otorhinolaryngol Relat Spec 2021 May 5:1-6. Epub 2021 May 5.

ENT Section, Department of Medical, Surgical and Advanced Technologies G.F. Ingrassia, University of Catania, Catania, Italy.

Secondary aphonia significantly affects the quality of life of the laryngectomy patient despite the excellent success of the operation. Vocal rehabilitation often does not achieve the desired results, given the innumerable prognostic variables. Tracheo-oesophageal speech is considered the standard gold method of voice restoration, but a possible spasm of pharyngo-oesophageal segment is the prominent cause of rehabilitation failure. Read More

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[Treatment satisfaction in patients with cervical dystonia : Subgroup analysis of INTEREST-IN-CD-2].

Nervenarzt 2021 May 3. Epub 2021 May 3.

Universitätsklinik für Neurologie, Medizinische Universität Wien, Wien, Österreich.

Background: Even though treatment guidelines recommend botulinum neurotoxin A (BoNT-A) as first line treatment for primary cervical dystonia (CD), there are only limited data on how BoNT-A-injections are administered in routine clinical practice.

Objective: This subgroup analysis evaluated patient satisfaction and symptom control under consideration of BoNT‑A treatment modalities in German and Austrian CD patients (DE/AT, n = 79) compared to the full international cohort (n = 995).

Material And Methods: The INTEREST-IN-CD2 was a prospective, multicenter, longitudinal observational study. Read More

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The Dystonia Coalition: A Multicenter Network for Clinical and Translational Studies.

Front Neurol 2021 8;12:660909. Epub 2021 Apr 8.

Department of Neurology, Emory University School of Medicine, Atlanta, GA, United States.

Dystonia is a movement disorder characterized by sustained or intermittent muscle contractions causing abnormal postures, repetitive movements, or both. Research in dystonia has been challenged by several factors. First, dystonia is uncommon. Read More

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Laryngeal spasm and tracheostomy after hydroxyapatite injection laryngoplasty.

Eur Ann Otorhinolaryngol Head Neck Dis 2021 Apr 15. Epub 2021 Apr 15.

Service ORL et chirurgie cervico-faciale, CHU de Strasbourg, 1 avenue Molière, 67098 Strasbourg cedex, France.

Introduction: Adductor spasmodic dysphonia (Ad-SD) is usually treated by botulinum toxin injection into the thyroarytenoid muscles. In older patients, atrophy of these muscles is responsible for glottic leak, causing presbyphonia and is managed by vocal fold medialization using autologous fat or hydroxyapatite (HA). We report the first case of uncontrollable laryngeal spasm requiring tracheostomy after hydroxyapatite injection laryngoplasty in a patient with spasmodic dysphonia and presbyphonia. Read More

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Thalamic Deep Brain Stimulation for Spasmodic Dysphonia: A Phase I Prospective Randomized Double-Blind Crossover Trial.

Neurosurgery 2021 Jun;89(1):45-52

Division of Otolaryngology, University of British Columbia, Vancouver, Canada.

Background: Adductor spasmodic dysphonia (SD) is a dystonia of the vocal folds causing difficulty with speech. The current standard of care is repeated botulinum toxin injections to weaken the adductor muscles. We sought to ameliorate the underlying neurological cause of SD with a novel therapy-deep brain stimulation (DBS). Read More

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Laryngeal Dystonia: Multidisciplinary Update on Terminology, Pathophysiology, and Research Priorities.

Neurology 2021 05 15;96(21):989-1001. Epub 2021 Apr 15.

From the Department of Otolaryngology-Head and Neck Surgery (K.S.), Harvard Medical School and Massachusetts Eye and Ear, Boston, MA, Department of Neurology (K.S., L.J.O., N.S.), Massachusetts General Hospital, Boston, MA; Division of Otolaryngology (J.B.-K.), University of Utah, Salt Lake City, UT; New York Center for Voice and Swallowing Disorders and Department of Neurology (A.B.), Icahn School of Medicine at Mount Sinai, New York, NY; Human Motor Control Section (M.H.), National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD; Department of Otolaryngology-Head and Neck Surgery (J.H.), University of California San Francisco, San Francisco, CA; School of Rehabilitation and Health Sciences (T.J.K.), Massachusetts General Hospital Institute of Health Professions, Boston, MA; Department of Otolaryngology-Head and Neck Surgery (M.J.P.), Columbia University Irving Medical Center, New York, NY; Department of Neurosurgery (R.M.R.), Massachusetts General Hospital, Boston, MA; and Department of Communication Disorders (K.T.), Brigham Young University, Provo, UT.

Objective: To delineate research priorities for improving clinical management of laryngeal dystonia, the NIH convened a multidisciplinary panel of experts for a 1-day workshop to examine the current progress in understanding its etiopathophysiology and clinical care.

Methods: The participants reviewed the current terminology of disorder and discussed advances in understanding its pathophysiology since a similar workshop was held in 2005. Clinical and research gaps were identified, and recommendations for future directions were delineated. Read More

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Botulinum toxin type A versus anticholinergics for cervical dystonia.

Cochrane Database Syst Rev 2021 04 14;4:CD004312. Epub 2021 Apr 14.

Laboratory of Clinical Pharmacology and Therapeutics, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal.

Background: This is an update of a Cochrane Review first published in 2005. Cervical dystonia is the most common form of focal dystonia and is a highly disabling movement disorder, characterised by involuntary, usually painful, head posturing. Currently, botulinum toxin type A (BtA) is considered the first line therapy for this condition. Read More

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Reappearance of Symptoms after GPi-DBS Discontinuation in Cervical Dystonia.

Mov Disord Clin Pract 2021 Apr 26;8(3):406-411. Epub 2021 Feb 26.

Clinical Neurosciences University of Turku Turku Finland.

Background: Deep brain stimulation of the globus pallidus interna (GPi-DBS) is a highly efficacious treatment for cervical dystonia. Typically, the treatment response is delayed, appearing and increasing even months after implantation. However, it is not known how fast the symptoms reappear and whether there is a long-term therapeutic effect after the stimulation is discontinued. Read More

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Brainstem Reflexes in Idiopathic Cervical Dystonia: Does Medullary Dysfunction Play a Role?

Mov Disord Clin Pract 2021 Apr 12;8(3):377-384. Epub 2021 Feb 12.

Department of Clinical and Movements Neurosciences, UCL Queen Square Institute of Neurology University College London London United Kingdom.

Background: Neurophysiological markers in dystonia have so far not been sistematically applied in clinical practice due to limited reproducibility of results and low correlations with clinical findings. Exceptions might be represented by the blink reflex (BR), including its recovery cycle (BRRC) and the trigemino-cervical reflex (TCR) which, compared to other neurophysiological methods, have shown more consistent alterations in cervical dystonia (CD). However, a comparison between the two techniques, and their possible correlation with disease symptoms, have not been thoroughly investigated. Read More

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Neurophysiological and ophthalmological findings of SPG7-related spastic ataxia: a phenotype study in an Irish cohort.

J Neurol 2021 Mar 27. Epub 2021 Mar 27.

National Ataxia Clinic, Department of Neurology, Tallaght University Hospital, Tallaght, Dublin 24, Ireland.

Background: Mutations in SPG7 are increasingly identified as a common cause of spastic ataxia. We describe a cohort of Irish patients with recessive SPG7-associated phenotype.

Methods: Comprehensive phenotyping was performed with documentation of clinical, neurophysiological, optical coherence tomography (OCT) and genetic data from individuals with SPG7 attending two academic neurology units in Dublin, including the National Ataxia Clinic. Read More

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Adherence of Doctors to Standard Diarrhoeal Management Guideline During Treatment of Under-Five Diarrhoeal Episodes: A Study From Eastern India.

Cureus 2021 Feb 18;13(2):e13433. Epub 2021 Feb 18.

Community Medicine and Family Medicine, All India Institute of Medical Sciences, Bhubaneswar, Bhubaneswar, IND.

Introduction Diarrhoea is one of the major preventable causes of childhood death in tribal areas of India. Most acute diarrhoea in childhood can be managed with oral rehydration salt (ORS) and zinc. This study aimed to assess the adherence of doctors to standard diarrheal management guidelines while treating under-five diarrhoeal episodes. Read More

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February 2021

Non-aesthetic uses of botulinum toxin in the head and neck.

Eur Arch Otorhinolaryngol 2021 Mar 18. Epub 2021 Mar 18.

Department of Otolaryngology, Lewisham and Greenwich NHS Trust, Lewisham High Street, London, SE13 6LH, UK.

Introduction: The use of botulinum toxin in the specialty of aesthetic surgery in the head and neck is well known. However, it has also been used for other conditions affecting the head and neck, and in recent years its use, as well as the number of relevant applications, has expanded enormously.

Review: This article presents a summary of the current range of uses in the laryngeal, pharyngeal, cervical, oromandibular and facial muscles and salivary glands. Read More

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Predicting Communicative Participation in Adults Across Communication Disorders.

Am J Speech Lang Pathol 2021 Mar 3:1-13. Epub 2021 Mar 3.

Department of Rehabilitation Medicine, University of Washington, Seattle.

Purpose The purpose of this study was to explore the extent to which communicative participation differs across diagnoses and if there are common predictor variables for communicative participation across diagnoses. Method Survey data on self-report variables including communicative participation were collected from 141 community-dwelling adults with communication disorders due to Parkinson's disease, cerebrovascular accident, spasmodic dysphonia, or vocal fold immobility (VFI). Analysis of covariance was used to determine communicative participation differences between diagnoses, with age, sex, and hearing status as covariates. Read More

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Clinical Improvement After Treatment With IncobotulinumtoxinA (XEOMIN®) in Patients With Cervical Dystonia Resistant to Botulinum Toxin Preparations Containing Complexing Proteins.

Front Neurol 2021 9;12:636590. Epub 2021 Feb 9.

Department of Neurology, University of Düsseldorf, Düsseldorf, Germany.

This study investigated the clinical long-term effect of incobotulinumtoxinA (incoBoNT/A) in 33 cervical dystonia (CD) patients who had developed partial secondary therapy failure (PSTF) under previous long-term botulinum toxin (BoNT) treatment. Patients were treated four times every 12 weeks with incoBoNT/A injections. Physicians assessed treatment efficacy using the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) at the baseline visit, week 12 and 48. Read More

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February 2021

Otolaryngeal and Oropharyngeal Conditions: Dysphonia.

Robert L Gauer

FP Essent 2021 Feb;501:11-16

Uniformed Services University F Edward Hébert School of Medicine Department of Family Medicine, 4301 Jones Bridge Road A1038, Bethesda, MD 20814-4799.

Dysphonia is any alteration of voice quality or vocal effort that impairs communication and affects quality of life. In patients with dysphonia, voice qualities often are described as tremulous, hoarse, strained, or raspy, with altered pitch, breathiness, or vocal fatigue. Dysphonia is a sign of an underlying disease process. Read More

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February 2021

A multicenter, randomized controlled trial of massage in children with pediatric cerebral palsy: Efficacy of pediatric massage for children with spastic cerebral palsy.

Medicine (Baltimore) 2021 Feb;100(5):e23469

First Clinical Medical College, Nanjing University of Chinese Medicine, 282 Hanzhong Road, Gulou, Nanjing, Jiangsu.

Background: Cerebral palsy is 1 of the diseases critically affecting the health of children. The spasmodic type is the most common, characterized by the increased muscular tension. It often leads to lifelong disability, bringing a heavy economic burden to families and society. Read More

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February 2021

"Orofacial Dystonia-A Silent Killer": Mandibular Fractures with Orofacial Dystonia, A Report of a Case and Review.

Case Rep Dent 2021 25;2021:6675961. Epub 2021 Jan 25.

Department of Oral and Maxillofacial Surgery, MCODS, Manipal, India.

Mandibular parasymphysis fracture is very commonly observed especially in old age when there is resorptions of the alveolar ridges. In cervical dystonia, there is centrally mediated disease in which there is uncontrolled and spasmodic contraction of the facial and the masticatory muscles. Due to the application of this sudden and uncontrolled force, there is a tendency of the bone to unfavourably remodel and weaken. Read More

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January 2021

Quality of life in isolated dystonia: non-motor manifestations matter.

J Neurol Neurosurg Psychiatry 2021 Feb 9. Epub 2021 Feb 9.

Department of Neurology, University of Luebeck, Luebeck, Germany

Objective: To evaluate the relationship between health-related quality of life (HR-QoL) and both physical and psychiatric factors in a large, international, multicentre cohort of patients with isolated dystonia, the Dystonia Coalition.

Methods: Natural history data from 603 patients with isolated dystonia (median age 57 years (IQR: 48 to 64 years), 67.0% women) were prospectively acquired and analysed. Read More

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February 2021