2,377 results match your criteria Spasmodic Dysphonia


Methicillin-resistant Staphylococcus aureus Meningitis as a Complication of Facial Nerve Decompression for Vertebrobasilar Dolichoectasia.

Cureus 2018 Oct 1;10(10):e3392. Epub 2018 Oct 1.

Radiology, VA Medical Center, Riviera Beach, USA.

We present a case of a 55-year-old lady with intermittent twitching of the left side of her face, involving her left eyelid and the angle of the mouth, ongoing for two years. She failed multiple trials of botulinum toxin injections as well as oral anti-spasmodic medications. The patient was diagnosed with an ectatic left vertebral artery, causing a compression of cranial nerve VII on the same side on magnetic resonance imaging (MRI) of the brain. Read More

View Article
October 2018
8 Reads

Treatment of psychiatric disturbances in common hyperkinetic movement disorders.

Expert Rev Neurother 2018 Dec 1. Epub 2018 Dec 1.

b Department of Human Neurosciences , Sapienza University of Rome , Rome.

Introduction: This paper reviews studies that have assessed the treatment of psychiatric disturbances in dystonia, tic disorders, Tourette syndrome, Huntington's disease and essential tremor. Areas covered: We searched for papers in English in Pubmed using the following keywords: blepharospasm, cervical dystonia, arm dystonia, laryngeal dystonia, spasmodic dysphonia, tic disorders, Tourette syndrome, Huntington's chorea, essential tremor, depression, anxiety, obsessive compulsive disorders, attention deficit hyperactivity disorders, psychosis, apathy. Expert commentary: Although psychiatric disturbances are frequent in hyperkinetic movement disorders, few controlled studies have assessed the treatment of psychiatric disturbances in such disorders. Read More

View Article
December 2018
4 Reads

Saffron petal as a new pharmacological target: a review.

Iran J Basic Med Sci 2018 Nov;21(11):1091-1099

Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Saffron petal is the main by-product of saffron processing which produced at high level but it is not applied and thrown out. Saffron petal is containing of several compounds such as mineral agents, anthocyanins, flavonoids, glycosides, alkaloids and kaempferol. As saffron petal is cheaper and produces in large amounts compared to saffron stigma, so, it can be considered as an appropriate source for different purposes. Read More

View Article
November 2018
3 Reads

A Randomized Control Trial Comparing Outcome after Stented and Nonstented Anderson-Hynes Dismembered Pyeloplasty.

J Indian Assoc Pediatr Surg 2018 Oct-Dec;23(4):186-191

Department of General Surgery, Government Medical College, Nagpur, Maharashtra, India.

Aim: The aim of the study was to compare the efficacy and postoperative complications of stented and nonstented open pediatric dismembered pyeloplasty for ureteropelvic junction (UPJ) obstruction.

Settings And Design: A balanced, parallel group, prospective randomized controlled trial comparing stented and nonstented Anderson-Hynes Dismembered Pyeloplasty.

Subjects And Methods: It included 42 children who required Anderson-Hynes dismembered pyeloplasty for UPJ obstruction (UPJO). Read More

View Article
November 2018
3 Reads

Defining differences in patient characteristics between spasmodic dysphonia and laryngeal tremor.

Laryngoscope 2018 Nov 13. Epub 2018 Nov 13.

Division of Otolaryngology, Wisconsin Surgical Outcomes Research, Department of Surgery, University of Wisconsin, Madison, Wisconsin, U.S.A.

Objective: To compare presenting characteristics of patients with adductor spasmodic dysphonia (ADSD), ADSD with laryngeal tremor (ADSD + LT), and laryngeal tremor without ADSD (LT).

Design: Cross-sectional analysis.

Methods: Patients treated for laryngeal movement disorders (1990-2016) were included. Read More

View Article
November 2018
7 Reads

Deep Brain Stimulation Versus Peripheral Denervation for Cervical Dystonia: A Systematic Review and Meta-Analysis.

World Neurosurg 2018 Nov 10. Epub 2018 Nov 10.

Department of Neurosurgery, Vanderbilt University Medical Center School, Nashville, Tennessee, USA. Electronic address:

Background: Cervical dystonia is a disabling medical condition that drastically decreases quality of life. Surgical treatment consists of peripheral nerve denervation procedures with or without myectomies or deep brain stimulation (DBS). The current objective was to compare the efficacy of peripheral denervation versus DBS in improving the severity of cervical dystonia through a systematic review and meta-analysis. Read More

View Article
November 2018
1 Read
2.417 Impact Factor

Possible Sertraline-Induced Hiccups in a Boy With Obsessive-Compulsive Disorder and Attention-Deficit/Hyperactivity Disorder.

Authors:
Ayhan Bilgiç

Clin Neuropharmacol 2018 Nov 5. Epub 2018 Nov 5.

Department of Child and Adolescent Psychiatry, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey.

Hiccup is a sudden-onset repeated involuntary and spasmodic contraction of the diaphragm and intercostal muscle accompanied by laryngeal closure, generating the characteristic inspiratory sound and discomfort. Various factors including drugs may trigger the hiccups. There are some reports regarding the possible links between psychotropic agents that can affect the dopaminergic system and the triggering of hiccup; however, to our knowledge, there are no data regarding sertraline-induced hiccup. Read More

View Article
November 2018
4 Reads

Hyperphysiological F-18 Fludeoxyglucose Uptake of Masticator Muscles in a Case of Awake Bruxism.

Indian J Nucl Med 2018 Oct-Dec;33(4):342-344

Department of Nuclear Medicine and PET CT, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.

F-18 FDG is a tracer of glucose metabolism, which is commonly used in PET/CT for oncological diagnosis and staging. F-18 FDG uptake represents the glycolytic activity in the cell. Physiological FDG concentration may be noted often in the muscles of head and neck, tongue, muscles on mastication, extra ocular muscles due to eye movements, cricopharyngeus and posterior cricoarytenoid muscles on phonation, etc. Read More

View Article
November 2018
3 Reads

Genuine and Sequestered Natural Products from the Genus Orobanche (Orobanchaceae, Lamiales).

Molecules 2018 Oct 30;23(11). Epub 2018 Oct 30.

Pharmazeutisches Institut, Abteilung Pharmazeutische Biologie, Christian-Albrechts-Universität zu Kiel, Gutenbergstraße 76, 24118 Kiel, Germany.

The present review gives an overview about natural products from the holoparasitic genus (Orobanchaceae). We cover both genuine natural products as well as compounds sequestered by taxa from their host plants. However, the distinction between these two categories is not always easy. Read More

View Article
October 2018
2 Reads

[Hardware- software complex for the differential diagnosis and evaluation of the effictiveness of treatment of extrapyramidal diseases].

Authors:
O E Khutorskaya

Zh Nevrol Psikhiatr Im S S Korsakova 2018 ;118(6. Vyp. 2):99-104

Trapeznikov Institute of Control Sciences of Russian Academy of Sciences, Moscow, Russia.

The hardware-software system of differential diagnosis and evaluation of the efficacy of treatment of a number of extrapyramidal diseases (Parkinson's disease, essential tremor, idiopathic cervical dystonia) is based on the methodology of special processing of the electrical activity of muscles (EMG). The system defines the diagnosis for each investigated muscle, and determine various forms of extrapyramidal diseases including early preclinical ones. The system allows viewing the dynamics of changes in the patient's state, both in numerical characteristics and in the graphic interpretation, and evaluates the efficacy of various forms of treatment (medicament, surgical, etc. Read More

View Article
January 2018
1 Read

OnabotulinumtoxinA for adductor spasmodic dysphonia (ADSD): Functional results and the role of dosage.

Toxicon 2018 Dec 10;155:38-42. Epub 2018 Oct 10.

Department of Aging, Neuroscience, Orthopedics and Head and Neck Sciences, UOC of Otorhinolaryngology, Istituto di Otorinolaringoiatria "Fondazione Policlinico Univeristario A. Gemelli IRCCS, Roma - Università Cattolica del Sacro Cuore", Italy.

Objective: To report the results of functional outcome, dose trend and relationship between onabotulinumtoxinA (onabotA) dosage and the severity of disease or time between therapy sessions in patients affected by adductor spasmodic dysphonia (ADSD).

Patients And Methods: Thirty-two patients underwent 193 EMG-guided intracordal injections of a starting dose of 2 MU of onabotA. At enrollment, each subject was administered the VHI. Read More

View Article
December 2018
2 Reads

Validation of the OMNI vocal effort scale in the treatment of adductor spasmodic dysphonia.

Laryngoscope 2018 Oct 12. Epub 2018 Oct 12.

USC Voice Center, Department of Otolaryngology Head and Neck Surgery, University of Southern California, Los Angeles, California, U.S.A.

Objectives: To establish the validity of the OMNI Vocal Effort Scale (OMNI-VES) for resistance exercise, a single-question pictorial scale, in voice-related perceived exertion. Additionally, the study aimed to assess the role of the OMNI-VES as an outcome measurement in the treatment of adductor spasmodic dysphonia (ADSD).

Methods: A prospective validation study was conducted on 226 participants. Read More

View Article
October 2018
3 Reads

Pharmacological and nutritive potential of Euphorbia granulata.

J Complement Integr Med 2018 Oct 12. Epub 2018 Oct 12.

University College of Conventional Medicine, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.

Background Euphorbia granulata is herb of family Euphorbiaceae having several traditional uses. The aim of the study is to summarize reported nutritional and medicinal value along with ethnomedical records. Methods The papers on nutritional and medicinal value of E. Read More

View Article
October 2018
6 Reads

A randomized comparative study of herbal decoction of Cassia fistula Linn pod's pericarp and Myristica fragrans Houtt arils vs. mefenamic acid in spasmodic dysmenorrhoea.

J Complement Integr Med 2018 Oct 12. Epub 2018 Oct 12.

Dept of Ilmul Qabalat wa Amraze Niswan (OBG), National Institute of Unani Medicine, Bengaluru, India.

Background To compare the efficacy and safety of herbal decoction (pods of Cassia fistula Linn. and Arils of Myristica fragrans Houtt) with mefenamic acid in spasmodic dysmenorrhoea. Methods In this single-blind, prospective, parallel, standard controlled study, dysmenorrheic patients (n=64) were randomly allocated to receive herbal decoction (n=31) or mefenamic acid (n=33) for two consecutive menstrual cycles. Read More

View Article
October 2018
14 Reads

Task-specificity in focal dystonia is shaped by aberrant diversity of a functional network kernel.

Mov Disord 2018 Sep 27. Epub 2018 Sep 27.

Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.

Objectives: Task-specific focal dystonia selectively affects the motor control during skilled and highly learned behaviors. Recent data suggest the role of neural network abnormalities in the development of the pathophysiological dystonic cascade.

Methods: We used resting-state functional MRI and analytic techniques rooted in network science and graph theory to examine the formation of abnormal subnetwork of highly influential brain regions, the functional network kernel, and its influence on aberrant dystonic connectivity specific to affected body region and skilled motor behavior. Read More

View Article
September 2018

Botulinum Toxin Injection for Lower Face and Oral Cavity Raynaud Phenomenon After Mandibulectomy, Free Fibula Reconstruction, and Radiation Therapy.

Ann Plast Surg 2019 Jan;82(1):53-54

Department of Plastic Surgery, MD Anderson Cancer Center, Houston, TX.

Isolated lingual and lower face Raynaud phenomenon without primary Raynaud of the digits is a very rare condition associated with chemoradiation therapy (RT) in previous reports. The condition, which more commonly presents in patients with a history of Raynaud disease, is often self-limiting, but vasodilating agents and steroids have been suggested as possible treatment options. Spasmodic torticollis is a different, more common entity, also associated with history of RT or previous head and neck surgery. Read More

View Article
January 2019
6 Reads

Botulinum neurotoxin for the treatment of movement disorders.

Aust J Gen Pract 2018 Sep;47(9):598-601

MD (Med), DM (Neuro), FRACP, Neurologist, Staff Specialist, Canberra Hospital.

Background: Botulinum neurotoxin (BoNT) is an exotoxin that causes neuromuscular weakness. BoNT serotypes A and B have been used for decades for the safe and effective treatment of various movement disorders, including some forms of focal dystonia. These conditions, such as cervical dystonia, hemifacial spasm, blepharospasm and spasmodic dysphonia, can have a substantial impact on patients' quality of life, but are often under-recognised. Read More

View Article
September 2018

Anatomical Course of the Thyroarytenoid Branch of the Recurrent Laryngeal Nerve.

Laryngoscope 2018 Sep 12. Epub 2018 Sep 12.

Bombay Hospital Voice and Swallowing Centre, Bombay Hospital and Medical Research Centre, Mumbai, India.

Objectives/hypothesis: To determine the position and anatomic variability of the thyroarytenoid (TA) branch of the recurrent laryngeal nerve (RLN) in an Indian population. This study is specifically targeted to aid in identifying the nerve for reinnervation procedures for unilateral and bilateral vocal fold paralysis, as well as denervation surgeries such as TA myoneurectomy and Selective Laryngeal Adductor Denervation and Reinnervation (SLAD-R) for adductor spasmodic dysphonia.

Methods: We dissected 46 fresh-frozen adult larynges (92 sides) without pathology. Read More

View Article
September 2018
10 Reads
2.032 Impact Factor

Bilateral Posterior Cricoarytenoid Myoneurectomy for Abductor Spasmodic Dysphonia.

J Voice 2018 Aug 30. Epub 2018 Aug 30.

Drexel University College of Medicine, Department of Otolaryngology - Head & Neck Surgery, Philadelphia, Pennsylvania. Electronic address:

Objective: To discuss the utility and outcomes of bilateral myoneurectomy for treatment of abductor spasmodic dysphonia.

Methods: Bilateral myoneurectomy is a known treatment option for patients with adductor spasmodic dysphonia. Its use for treatment of abductor spasmodic dysphonia, however, has not been documented previously. Read More

View Article
August 2018
1 Read

Quality of life improvements in patients with cervical dystonia following treatment with a liquid formulation of abobotulinumtoxinA (Dysport ).

Eur J Neurol 2018 Aug 31. Epub 2018 Aug 31.

Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.

Background And Purpose: In patients with cervical dystonia, abobotulinumtoxinA solution for injection (ASI) has been shown to be similarly effective to freeze-dried abobotulinumtoxinA in reducing Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) total scores. In this secondary analysis, quality of life data as evaluated with the Cervical Dystonia Impact Profile (CDIP-58) are presented.

Methods: This was a double-blind, randomized, active and placebo-controlled study followed by an open-label extension (NCT01261611). Read More

View Article
August 2018
4 Reads

Acupuncture as Adjuvant Therapy for the Management of Cervical Dystonia.

Med Acupunct 2018 Aug;30(4):198-203

Osher Center for Integrative Medicine. Northwestern University, Chicago, IL.

There are no curative treatments for cervical dystonia (CD), therefore conventional management is aimed at pain relief and muscle relaxation. Many patients with CD use complementary and integrative medicine interventions to manage symptoms, yet there are limited data on the use of acupuncture for CD. The aim of the current study was to determine the feasibility, safety, and efficacy of adjuvant acupuncture. Read More

View Article
August 2018
7 Reads

Effect of Artemisia herba-alba consumption during pregnancy on fertility, morphological and behaviors of mice offspring.

J Ethnopharmacol 2018 Nov 16;226:105-110. Epub 2018 Aug 16.

Laboratory of Pharmacology, Neurobiology and Behavior, Semlalia Faculty of Sciences, Cadi Ayyad University, Marrakech, Morocco. Electronic address:

Ethnopharmacological Relevance: Pregnant women prefer herbal medicines more than pharmaceutical drugs due to the cultural belief that herbs are more suffer during pregnancy for an accurate foetus development. Artemisia herba-alba (Asteraceae) is one of the most used plants in the Mediterranean region to treat various diseases including diabetes, hypertension, spasmodic dysphonia and some bacterial infection.

Aim Of The Study: The present study aimed to investigate the effect of Artemisia herba-alba consumption during pregnancy on fertility, physical and behavior developments of mice offspring from birth-to-weaning days. Read More

View Article
November 2018
5 Reads

Impact of Hyoscine Bromide Use on Polyp Detection Rate During Colonoscopy: A Systematic Review and Meta-Analysis.

Gastroenterology Res 2018 Aug 8;11(4):295-304. Epub 2018 Feb 8.

Department of Medicine, Drexel University College of Medicine, Philadelphia, PA, USA.

Background: Colorectal cancer (CRC) is a leading cause of death worldwide. Polyp detection rate (PDR) and adenoma detection rate (ADR) are key focus in endoscopic research for CRC screening and prevention. Use of anti-spasmodic agents during colonoscopy to help identify adenomas and polyps has remained a controversial topic. Read More

View Article
August 2018
7 Reads

Anxiety and depression in spasmodic dysphonia patients.

World J Otorhinolaryngol Head Neck Surg 2018 Jun 18;4(2):110-116. Epub 2018 Jun 18.

Department of Otolaryngology - Head & Neck Surgery, University of Washington, Seattle, WA, USA.

Objective/hypothesis: Experts used to believe that spasmodic dysphonia (SD) was a psychogenic disorder. Although SD is now established as a neurological disorder, the rates of co-morbid anxiety and depression range from 7.1% to 62%. Read More

View Article
June 2018
1 Read

Moutan Cortex Radicis inhibits the nigrostriatal damage in a 6-OHDA-induced Parkinson's disease model.

Chin J Nat Med 2018 Jul;16(7):490-498

Research Group of Pain and Neuroscience, WHO Collaborating Center for Traditional Medicine, East-West Medical Research Institute, Kyung Hee University, Seoul 02447, Republic of Korea; Department of Applied Korean Medicine, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea. Electronic address:

The traditionally used oriental herbal medicine Moutan Cortex Radicis [MCR; Paeonia Suffruticosa Andrews (Paeoniaceae)] exerts anti-inflammatory, anti-spasmodic, and analgesic effects. In the present study, we investigated the therapeutic effects of differently fractioned MCR extracts in a 6-hydroxydopamine (OHDA)-induced Parkinson's disease model and neuro-blastoma B65 cells. Ethanol-extracted MCR was fractionated by n-hexane, butanol, and distilled water. Read More

View Article

Objective Indices of Perceived Vocal Strain.

J Voice 2018 Jul 28. Epub 2018 Jul 28.

Department of Communication Sciences and Disorders, University of South Florida, Tampa, Florida.

Background: A limited number of experiments have investigated the perception of strain compared to the voice qualities of breathiness and roughness despite its widespread occurrence in patients who have hyperfunctional voice disorders, adductor spasmodic dysphonia, and vocal fold paralysis among others.

Objective: The purpose of this study is to determine the perceptual basis of strain through identification and exploration of acoustic and psychoacoustic measures.

Methods: Twelve listeners evaluated the degree of strain for 28 dysphonic phonation samples on a five-point rating scale task. Read More

View Article
July 2018
1 Read

Stroke-induced resolution of primary blepharospasm: evidence for the lenticular nucleus as a control candidate.

BMJ Case Rep 2018 Jul 25;2018. Epub 2018 Jul 25.

Department of Oculoplastics, Moorfields Eye Hospital, London, UK.

Primary blepharospasm is an adult-onset focal dystonia characterised by involuntary contractions of the orbicularis oculi, leading to bilateral spasmodic closure of the eyelids. While spasms of this muscle constitute the hallmark of disease, other motor manifestations include increased spontaneous blinking and apraxia of eyelid opening. Originally misdiagnosed as a psychiatric condition, blepharospasm is now well established as being of neurological origin although questions remain as to its pathophysiological mechanisms. Read More

View Article
July 2018
5 Reads

Mini-Review- A mini-review of therapeutic potential of Mangifera indica L.

Pak J Pharm Sci 2018 Jul;31(4):1441-1448

Depertment of Botany, Pir Mehr Ali Shah Arid Agriculture University, Rawalpindi, Pakistan.

Among known species of 69 Mangifera, Mangifera indica L. is a medicinal plant being used in tropical regions by indigenous people. It has been a main plant species being used in Ayurvedic as well as indigenous medical systems form 4000 years. Read More

View Article
July 2018
8 Reads

Isolated focal dystonia phenotypes are associated with distinct patterns of altered microstructure.

Neuroimage Clin 2018 5;19:805-812. Epub 2018 Jun 5.

Department of Radiology, University of Colorado School of Medicine, Aurora, CO, United States; Department of Radiology, University of Florida, Gainesville, FL, United States.

Objective: Isolated adult-onset focal dystonia is considered a network disorder with disturbances to the motor basal ganglia and cerebellar circuits playing a pathophysiological role, but why specific body regions become affected remains unknown. We aimed to use diffusion tensor imaging to determine if the two most common phenotypes of focal dystonia are associated with distinguishing microstructural changes affecting the motor network.

Methods: Fifteen blepharospasm patients, 20 cervical dystonia patients, and 30 age- and sex-matched healthy controls were recruited. Read More

View Article
June 2018
14 Reads

Injectable DaxibotulinumtoxinA in Cervical Dystonia: A Phase 2 Dose-Escalation Multicenter Study.

Mov Disord Clin Pract 2018 May-Jun;5(3):273-282. Epub 2018 Apr 26.

Rush University Medical Center Chicago IL.

Background: Injectable daxibotulinumtoxinA (an investigational botulinum toxin, RT002) may offer a more prolonged duration of response-and therefore less frequent dosing-than onabotulinumtoxinA.

Objectives: To perform a phase 2, open-label, dose-escalation study to assess the efficacy and safety of daxibotulinumtoxinA in cervical dystonia.

Methods: Subjects with moderate-to-severe isolated cervical dystonia were enrolled in sequential cohorts to receive a single open-label, intramuscular dose of injectable daxibotulinumtoxinA of up to 200 U ( 12), 200-300 U ( 12), or 300-450 U ( 13; https://clinicaltrials. Read More

View Article
April 2018
9 Reads

A case report of pediatric calciphylaxis-a rare and potentially fatal under diagnosed condition.

Medicine (Baltimore) 2018 Jul;97(27):e11300

University of Medicine and Pharmacy Grigore T. Popa Iasi.

Rationale: Though to be rare, calcific uremic arteriolophathy (CUA) is an ectopic calcification entity causing pain and disabilities in patients with chronic renal insufficiency, thus increasing the morbidity and mortality.

Patient Concern: We report a case of four years old boy admitted with acute respiratory failure. Physical examination revealed: irritability, purple subcutaneous hard nodules, tachypnea, dry spasmodic cough, respiratory rate 45/min, heart rate 110/min, blood pressure 100/60 mmHg, with normal heart sounds, no murmurs, hepatomegaly with hepato-jugular reflux. Read More

View Article
July 2018
2 Reads

Oropharyngeal Dysphagia in Adults With Dyskinetic Cerebral Palsy and Cervical Dystonia: A Preliminary Study.

Arch Phys Med Rehabil 2018 Jun 26. Epub 2018 Jun 26.

Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea. Electronic address:

Objectives: To investigate the characteristics of oropharyngeal dysphagia in adults with dyskinetic cerebral palsy (DCP) and cervical dystonia (CD).

Design: Exploratory observational cross-sectional study.

Setting: University hospital. Read More

View Article
June 2018
16 Reads

The effects of a relaxation program featuring aquatic therapy and autogenic training among people with cervical dystonia (a pilot study).

Physiother Theory Pract 2018 Jun 25:1-10. Epub 2018 Jun 25.

c Center for Social and Cognitive Neuroscience(CSCN), School of Psychology , Universidad Adolfo Ibáñez , Santiago , Chile.

Classic physical interventions for cervical dystonia (CD) have focused on treating motor components or, on motor components and relaxation programs. However, no CD treatment study has focused on a relaxation program alone. We developed a pilot study to assess whether a therapy completely based on a relaxation program could improve the physical and mental symptomatologies of patients with CD. Read More

View Article
June 2018
18 Reads

Botulinum toxin-B injection into the lacrimal gland and posterior cricoarytenoid muscle for the treatment of epiphora and abductor spasmodic dysphonia secondary to Parkinson's disease.

Orbit 2018 Jun 25:1-4. Epub 2018 Jun 25.

a Department of Ophthalmology , Hereford County Hospital, Wye Valley NHS Trust , Hereford , United Kingdom.

In ophthalmology, there have been few reports of botulinum toxin type-A (BTX-A) injection into the lacrimal gland to treat epiphora. In ENT, adductor and abductor (ABSD) spasmodic dysphonia are often treated with BTX-A injections into the respective overacting vocal cord muscles. We describe a 53-year old male with Parkinson's disease who did not respond to BTX-A injections to either the lacrimal gland, for epiphora secondary to Parkinsonian-related blink lagophthalmos, or posterior cricoarytenoid (PCA) muscles for ABSD. Read More

View Article

Consensus-Based Attributes for Identifying Patients With Spasmodic Dysphonia and Other Voice Disorders.

JAMA Otolaryngol Head Neck Surg 2018 Aug;144(8):657-665

Department of Neurological Sciences, Rush Medical College, Chicago, Illinois.

Importance: A roadblock for research on adductor spasmodic dysphonia (ADSD), abductor SD (ABSD), voice tremor (VT), and muscular tension dysphonia (MTD) is the lack of criteria for selecting patients with these disorders.

Objective: To determine the agreement among experts not using standard guidelines to classify patients with ABSD, ADSD, VT, and MTD, and develop expert consensus attributes for classifying patients for research.

Design, Setting And Participants: From 2011 to 2016, a multicenter observational study examined agreement among blinded experts when classifying patients with ADSD, ABSD, VT or MTD (first study). Read More

View Article
August 2018
14 Reads

Low Voice, Spasmodic Dysphonia, and Hand Dystonia as Clinical Clues for KMT2B-Associated Early-Onset Dystonia.

Neuropediatrics 2018 Oct 18;49(5):356. Epub 2018 Jun 18.

Department of Pediatric Neurology, University Children's Hospital, Zürich, Switzerland.

View Article
October 2018
3 Reads

Interaction of pirenzepine with bovine serum albumin and effect of β-cyclodextrin on binding: A biophysical and molecular docking approach.

Arch Biochem Biophys 2018 Aug 14;652:27-37. Epub 2018 Jun 14.

Department of Biochemistry, Faculty of Life Sciences, A.M. University, Aligarh, U.P, 202002, India. Electronic address:

Studying the interaction of therapeutic molecules with serum albumin is important to understand their biopharmaceutics, pharmacokinetics and toxicity as well as their relation with the structure and function of protein. The biomolecular interaction of an anti-spasmodic drug, pirenzepine with bovine serum albumin (BSA) was investigated using multi-spectroscopic, calorimetric and docking studies. Fluorescence quenching of BSA on interaction with pirenzepine revealed the static mode of quenching. Read More

View Article
August 2018
3 Reads

Both Deep Brain Stimulation and Thalamotomy in a 13-Year-Old Patient with Primary Dystonia.

World Neurosurg 2018 Sep 8;117:68-73. Epub 2018 Jun 8.

Department of Neurosurgery, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China; Shenzhen Key Laboratory of Neurosurgery, Shenzhen, Guangdong, China; Shenzhen University School of Medicine, Shenzhen, Guangdong, China. Electronic address:

Background: Primary dystonia is a neurologic disease with characteristics of abnormal, involuntary twisting and turning movements, which greatly affect quality of life of patients. Treatments for dystonia consist of oral medications, botulinum neurotoxin injections, physical therapy, and surgery. For medication-refractory dystonia, surgery, especially deep brain stimulation (DBS), is the optimal option. Read More

View Article
September 2018
7 Reads

Quality of Life and Voice Changes After a Single Injection in Patients With ADSD Over Time.

J Voice 2018 Jun 5. Epub 2018 Jun 5.

Center for Spoken Language Understanding (CSLU), Oregon Health & Science University (OHSU), Portland OR, USA.

Introduction: Adductor spasmodic dysphonia (ADSD) is one of the most disabling voice disorders with no permanent cure. Patients with ADSD suffer from poor voice quality and repeated interruption of phonation that leads to limitations in daily communication. Botox (BT) injection, considered the gold standard treatment for ADSD, reduces the amount of voice breaks and improves voice quality for a limited period. Read More

View Article
June 2018
9 Reads

Traditional Uses, Pharmacological Efficacy, and Phytochemistry of (Forssk.) Fiori. -A Review.

Front Pharmacol 2018 11;9:465. Epub 2018 May 11.

Department of Arid Land Agriculture, College of Food and Agriculture, United Arab Emirates University, Al Ain, United Arab Emirates.

is a sole genus of Moringaceae family with 13 species distributed in the tropical and sub-tropical regions. Among them, is one of the species which has wide range of traditional, nutritional, industrial, and medicinal values. The plant parts are used in folk medicine for many human health care purposes including diabetes, wound healing, disinfectant, fever, constipation, muscle pains, slimness, burns, labor pain, hypertension, malaria, stomach disorder, asthma, skin problems, and to expel a retained placenta. Read More

View Article
May 2018
10 Reads

Towards a better understanding of Artemisia vulgaris: Botany, phytochemistry, pharmacological and biotechnological potential.

Food Res Int 2018 Jul 29;109:403-415. Epub 2018 Mar 29.

Health Sciences Graduate Program, Biological & Health Sciences Center, Federal University of Maranhão, São Luís, MA, Brazil. Electronic address:

Artemisia vulgaris is one of the important medicinal plant species of the genus Artemisia, which is usually known for its volatile oils. The genus Artemisia has become the subject of great interest due to its chemical and biological diversity as well as the discovery and isolation of promising anti-malarial drug artemisinin. A. Read More

View Article
July 2018
9 Reads

Neuropsychological consequences of pallidal deep brain stimulation altering brain networks.

J Clin Neurosci 2018 Aug 22;54:50-56. Epub 2018 May 22.

Department of Neurosurgery, Soonchunhyang University Bucheon Hospital, Soonchunhyang University, Gyeonggi-do Bucheon-si, Republic of Korea. Electronic address:

The purpose of this study was to evaluate postoperative changes in the neuropsychological function of cervical dystonia patients who had undergone deep brain stimulation (DBS) of the internal segment of the globus pallidus (GPi) and to investigate how DBS affects neuropsychological function by altering the neural networks of the brain. In 12 cervical dystonia patients, the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) was used to measure the preoperative and postoperative status of cervical dystonia, and the Seoul Neuropsychological Screening Battery was used to gather neuropsychological data. The data were analyzed using a Wilcoxon signed-rank test. Read More

View Article
August 2018
13 Reads

Botulinum Toxin Type A Injection for Cervical Dystonia in Adults with Dyskinetic Cerebral Palsy.

Toxins (Basel) 2018 May 16;10(5). Epub 2018 May 16.

Department of Rehabilitation Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, Korea.

We aimed to evaluate the efficacy and safety of injecting botulinum toxin A (BoNT-A) into the neck muscles to treat cervical dystonia (CD) in patients with dyskinetic cerebral palsy (CP). This was a randomized, double-blinded, placebo-controlled trial with cross-over design. We prospectively enrolled adults with dyskinetic CP who were over 20 years old and had been clinically diagnosed with CD for more than one year. Read More

View Article
May 2018
8 Reads

Salivary alpha-amylase activity and cortisol in horses with acute abdominal disease: a pilot study.

BMC Vet Res 2018 May 10;14(1):156. Epub 2018 May 10.

Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Veterinary School, Campus of Excellence Mare Nostrum, University of Murcia, 30100, Espinardo, Murcia, Spain.

Background: The aim of this study was to evaluate salivary alpha-amylase (sAA), considered a non-invasive biomarker for sympathetic nervous system (SNS) activity, and salivary cortisol as possible pain-induced stress biomarker, in horses with acute abdominal disease. Therefore, a prospective observational study was performed in which both biomarkers were analyzed in a group of horses with acute abdomen syndrome, and compared with a group of healthy control horses by an unpaired Student's t-test. In addition, the possible relationship between both biomarkers, the score in Equine Acute Abdominal Pain scales version 1 (EAAPS-1 scale), Heart Rate (HR) and Respiratory Rate (RR), plasma lactate, the systemic inflammatory response syndrome (SIRS) score and serum amyloid A (SAA) concentration was assessed by a Spearman correlation test. Read More

View Article
May 2018
8 Reads

Clinical experience with patients with spasmodic dysphonia and primary Meige syndrome.

Acta Otorrinolaringol Esp 2018 Apr 28. Epub 2018 Apr 28.

Departamento de Otorrinolaringología, Hospital Universitario La Paz, Madrid, España.

Introduction: Meige syndrome (MS) is part of the group of segmental cranial dystonias, which affect more than two cranial muscle groups. Specifically, blepharospasm is associated with another cranial dystonia (oromandibular, cervical or laryngeal). The aim of this paper was to report our experience in patients with spasmodic dysphonia (SD) associated with primary MS. Read More

View Article
April 2018
6 Reads

[Dynamic scalp acupuncture combined with PNF therapy for upper limb motor impairment in ischemic stroke spastic hemiplegia].

Zhongguo Zhen Jiu 2018 Mar;38(3):234-8

Department of Neurological Rehabilitation, Shanghai Seventh People Hospital Affiliated to Shanghai University of TCM, Shanghai 200137.

Objective: On the basic therapy, to assess the clinical effects of dynamic scalp acupuncture, scalp acupuncture combined with proprioceptive neuromuscular facilitation (PNF) therapy and simple PNF therapy for upper limb motor impairment in ischemic post-stroke spastic hemiplegia.

Methods: A total of 90 cases were randomly assigned into a PNF group, a dynamic scalp acupuncture group and a scalp acupuncture group, 30 cases in each group. Basic therapy and PNF therapy were applied in the three groups. Read More

View Article
March 2018
1 Read