2,574 results match your criteria South American Blastomycosis


Iron Deprivation Modulates the Exoproteome in .

Front Cell Infect Microbiol 2022 3;12:903070. Epub 2022 Jun 3.

Laboratório de Biologia Molecular, Instituto de Ciências Biológicas, ICB II, Campus II, Universidade Federal de Goiás, Goiânia, Brazil.

Fungi of the genus are the etiological agents of the systemic mycosis paracoccidioidomycosis and, when in the host, they find a challenging environment that is scarce in nutrients and micronutrients, such as Fe, which is indispensable for the survival of the pathogen. Previous studies have shown that fungi of this genus, in response to Fe deprivation, are able to synthesize and capture siderophores (Fe chelators), use Fe-containing host proteins as a source of the metal, and use a non-canonical reductive pathway for Fe assimilation. Despite all of these findings, there are still gaps that need to be filled in the pathogen response to metal deprivation. Read More

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Paracoccidioidomycosis in people living with HIV/AIDS: A historical retrospective cohort study in a national reference center for infectious diseases, Rio de Janeiro, Brazil.

PLoS Negl Trop Dis 2022 Jun 15;16(6):e0010529. Epub 2022 Jun 15.

Clinical Research Laboratory on Infectious Dermatology, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro, Brazil.

Paracoccidioidomycosis (PCM) is one of the main endemic systemic mycoses in Latin America, usually occurring in rural areas. When PCM occurs simultaneously with underlying immunosuppressive conditions, it can present as an opportunistic disease. Between 2000 and 2017, literature reported around 200 PCM cases in people living with HIV/AIDS (PLWHA). Read More

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Paracoccidioidomycosis: Endobronchial Involvement in a Rare Disease in Europe.

Arch Bronconeumol 2021 09;57(9):590

Anatomical Pathology Department, Hospital Central do Funchal, Portuga.

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September 2021

Disseminated paracoccidioidomycosis with skull and mandible involvement in a heart transplant recipient.

Rev Soc Bras Med Trop 2022 6;55:e0110. Epub 2022 Jun 6.

Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Departamento de Radiologia, Campinas, SP, Brasil.

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Seroprevalences Against Paracoccidioides cetii: A Causative Agent for Paracoccidiomycosis Ceti (PCM-C) and Coccidioides posadasii; for Coccidioidomycosis (CCM) in Dall's Porpoise (Phocoenoides dalli) and Harbor Porpoise (Phocoena phocoena) Stranded at Hokkaido, Japan.

Mycopathologia 2022 Jun 8. Epub 2022 Jun 8.

Department of Pathological Sciences, CCB, State University of Londrina, P.O. Box 6001, Londrina, Paraná, 86051-970, Brazil.

Paracoccidiodomycosis ceti (PCM-C) is a zoonotic mycosis characterized by chronic granulomatous cutaneous lesions in cetaceans. It is distributed worldwide and is caused by an unculturable fungus; Paracoccidioides cetii. On the other hand, coccidioidomycosis (CCM), caused by Coccidioides spp. Read More

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Disseminated paracoccidioidomycosis associated with lymph node tuberculosis in a non immunocompromised child.

IDCases 2022 20;29:e01507. Epub 2022 May 20.

Hospital Regional Materno Infantil El Carmen, Huancayo, Peru.

The association of paracoccidioidomycosis (PCM) and tuberculosis (TB) produces an uncommon hyperinflammatory syndrome, causing multiorgan dysfunction. TB associated PCM is a rare condition, but it is fatal if not treated. Herein, we present a immunocompetent child who is admitted for fever and painful lymphadenopathy, with evidence of acid-alcohol-resistant bacillus (AARB) in cervical lymph node biopsy, antituberculous treatment was started with partial clinical improvement and is given discharge from hospital. Read More

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Clinical and Eco-Epidemiological Aspects of a Novel Hyperendemic Area of Paracoccidioidomycosis in the Tocantins-Araguaia Basin (Northern Brazil), Caused by sp.

J Fungi (Basel) 2022 May 12;8(5). Epub 2022 May 12.

Núcleo de Medicina Tropical, Faculty of Medicine, University of Brasília, Campus Universitário Darcy Ribeiro, Brasília 70910-900, DF, Brazil.

Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis in Brazil. The disease is caused by dimorphic fungi nested within the Paracoccidioides genus. We described 106 PCM cases (47. Read More

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The Multifaceted Role of Mating Type of the Fungus and Sex of the Host in Studies of Fungal Infections in Humans.

Authors:
Nada Kraševec

J Fungi (Basel) 2022 Apr 29;8(5). Epub 2022 Apr 29.

Department of Molecular Biology and Nanobiotechnology, National Institute of Chemistry, SI-1000 Ljubljana, Slovenia.

This review discusses the inclusion of sex and gender variables in studies of fungal infections in humans at the pathogen, host, and antifungal trial levels. The mating type of some fungi, or perhaps more likely the absence of the other, appears to be associated with some infections. Sexual and parasexual reproduction of some fungi is an important mechanism for the development of antifungal drug resistance. Read More

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Paracoccidioidomycosis screening diagnosis by FTIR spectroscopy and multivariate analysis.

Photodiagnosis Photodyn Ther 2022 May 19:102921. Epub 2022 May 19.

Optics and Photonics Group, Institute of Physics, Federal University of Mato Grosso do Sul - UFMS, Brazil. Electronic address:

Paracoccidioidomycosis (PCM) is a systemic mycosis with high incidence in Latin America, caused by species of the genus Paracoccidioides spp. Brazil is considered to be the endemic center of this disease, which is identified as the eighth cause of mortality from chronic infectious disease in the country. There are several specific diagnostic methods in PCM, such as microbiological, immunological, histopathological, and molecular. Read More

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Head and neck manifestations of paracoccidioidomycosis: A retrospective study of histopathologically diagnosed cases in two medical centers in southern Brazil.

J Mycol Med 2022 May 3;32(3):101292. Epub 2022 May 3.

Postgraduate Program in Medicine: Medical Sciences, Universidade Federal do Rio Grande do Sul. Porto Alegre RS, Brazil; Department of Microbiology, Immunology and Parasitology, Universidade Federal do Rio Grande do Sul. Porto Alegre RS, Brazil. Electronic address:

Background: Paracoccidoidomycosis (PCM) is a granulomatous systemic mycosis endemic in southern Brazil.

Objectives: Analyze the clinical and epidemiological characteristics of cases of PCM with head and neck manifestations in southern Brazil.

Material And Methods: Retrospective study of histopathologically diagnosed cases of PCM with head and neck manifestations referred to two medical centers in the municipality of Santa Cruz do Sul, state of Rio Grande do Sul, Brazil, during a 10-year period (2011-2020). Read More

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Editorial: Immunological Memory to Fungal Infections and Vaccine Development.

Front Immunol 2022 27;13:880037. Epub 2022 Apr 27.

MRC Centre for Medical Mycology, University of Exeter, Exeter, United Kingdom.

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Paracoccidioidomycosis Simulating Eyelid Carcinoma.

Arch Iran Med 2022 03 1;25(3):194-195. Epub 2022 Mar 1.

Department of Dermatology, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.

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[Systemic paracoccidioidomycosis with compromise of the cecal appendix in a child: case report].

Rev Peru Med Exp Salud Publica 2021 Oct-Dec;38(4):660-663. Epub 2022 Apr 1.

Instituto Nacional de Salud del Niño San Borja, Lima, Perú.

Paracoccidioidomycosis, the most prevalent systemic mycosis in Latin America. In children the most common clinical presentation is the juvenile or acute/subacute form, which mainly involves the lymph nodes and in a lesser proportion the gastrointestinal organs. We present the case of a 10-year-old patient, without comorbidities, who presented acute right iliac fossa pain; in addition to a history of 1 month of evolution of diarrhea, fever, weight loss, and hypereosinophilia. Read More

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Extracellular Vesicles From Can Induce the Expression of Fungal Virulence Traits and Enhance Infection in Mice.

Front Cell Infect Microbiol 2022 28;12:834653. Epub 2022 Feb 28.

Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina-Universidade Federal de São Paulo (EPM-UNIFESP), São Paulo, Brazil.

Extracellular vesicles (EVs) are cellular components involved in cargo delivery to the extracellular environment, including the fungal cell wall. Their importance in cell-cell communication, cell wall remodeling, and fungal virulence is starting to be better explored. In the human pathogenic spp. Read More

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Lobomycosis and paracoccidioidomycosis meet again.

Rev Iberoam Micol 2022 Mar 10. Epub 2022 Mar 10.

Veterinary Mycology Group, Department of Animal Health and Anatomy, Veterinary School, Universitat Autònoma de Barcelona, Bellaterra, Spain. Electronic address:

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Mixed infection by and and coinfection with paracoccidioidomycosis in PLHIV.

Med Mycol Case Rep 2022 Mar 27;35:48-50. Epub 2022 Jan 27.

National Institute of Infectious Disease Evandro Chagas, Oswaldo Cruz Foundation, Rio de Janeiro, 21040-900, Brazil.

We present a rare condition of mixed and infection in a person living with HIV with false-negative CrAg LFA in the CSF and co-infection with paracoccidioidomycosis. Signs and symptoms are relative to respiratory tract and skin, confounding with other opportunistic disease. After negatives CrAg LFA and Indian ink staining in CSF, there was isolation of in sputum and in CSF, in addition to reagent serology (double immunodiffusion) for PCM with 1/16 titer. Read More

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Ileum thickening and biliary stenosis in a 26-year-old woman from Brazil.

Gastroenterology 2022 Mar 2. Epub 2022 Mar 2.

Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; D'Or Institute for Research and Education, Rio de Janeiro, Brazil. Electronic address:

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Paracoccidioidomycosis as an opportunistic manifestation of acquired immunodeficiency syndrome.

Rev Soc Bras Med Trop 2022;55:e0536. Epub 2022 Feb 25.

Universidade do Oeste Paulista, Programa de Pós-Graduação Lato Sensu em Dermatologia, Presidente Prudente, SP, Brasil.

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Phototherapies as an adjuvant treatment for oral paracoccidioidomycosis.

Photodiagnosis Photodyn Ther 2022 Jun 18;38:102771. Epub 2022 Feb 18.

Study Group of Laser and Health Institute. São Paulo, SP, Brazil; Graduate Program in Implantology, University of Santo Amaro, School of Dentistry. São Paulo, SP, Brazil. Electronic address:

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A Case of Neuroparacoccidioidomycosis in Houston, Texas.

Cureus 2022 Jan 11;14(1):e21129. Epub 2022 Jan 11.

Internal Medicine, University of Texas Health Science Center at Houston, Houston, USA.

Paracoccidioidomycosis is a systemic fungal disease caused by the dimorphic species endemic to South America. Infection classically presents with pulmonary, mucosal, or reticuloendothelial involvement, though other organs can be involved. Central nervous system involvement is rare, and almost universally reported within the endemic area for the fungus. Read More

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January 2022

Intestinal Paracoccidioidomycosis: Case report and literature review.

Int J Surg Case Rep 2022 Feb 29;91:106801. Epub 2022 Jan 29.

Faculty of Medicine, Universidad del Rosario, Colombia; Hospital Universitario Mayor de Mederi, Colombia.

Introduction And Importance: Paracoccidioidomycosis (PCM) is a systemic fungal infection, primarily affecting the respiratory tract. Extra pulmonary presentation is rare, representing less than 1% of cases (about 1 in every 200 cases).

Case Presentation: We present a case of a 73-year-old male with acute surgical abdomen secondary to Intestinal Paracoccidioidomycosis requiring intestinal resection and postoperative antifungal therapy. Read More

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February 2022

Biochemical characterization and analysis of gene expression of an α-mannosidase secreted by Paracoccidioides brasiliensis.

Med Mycol 2022 Feb;60(2)

Department of Biology, Faculty of Philosophy, Sciences and Letters at Ribeirão Preto, University of São Paulo, 14040-901, Ribeirão Preto, SP, Brazil.

Paracoccidioidomycosis (PCM) is a systemic mycosis caused by fungi of the Paracoccidioides genus, being endemic in Latin America and with the highest number of cases in Brazil. Paracoccidioides spp. release a wide range of molecules, such as enzymes, which may be important for PCM establishment. Read More

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February 2022

Brain paracoccidioidomycosis in an immunosuppressed patient with systemic lupus erythematosus.

Surg Neurol Int 2021 30;12:581. Epub 2021 Nov 30.

Graduate Medical Education, Piedmont Athens Regional Medical Center, Athens, Georgia, United States.

Background: Brain paracoccidioidomycosis (PCM) or neuroparacoccidioidomycosis (NPCM) is a fungal infection of the central nervous system (CNS) caused by , a dimorphic fungus. The CNS involvement is through bloodstream dissemination. The association between NPCM and systemic lupus erythematous (SLE) is rare. Read More

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November 2021

Current Status on Extracellular Vesicles from the Dimorphic Pathogenic Species of Paracoccidioides.

Authors:
Rosana Puccia

Curr Top Microbiol Immunol 2021 ;432:19-33

Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina-Universidade Federal de São Paulo (EPM-UNIFESP), São Paulo, SP, Brazil.

Species of the Paracoccidioides brasiliensis complex and P. lutzii cause human paracoccidioidomycosis (PCM). Early interest in Paracoccidioides extracellular vesicles (EVs) resulted in a series of publications that unraveled the EVs protein, carbohydrate, lipid, and RNA cargo from isolates of different phylogenetic groups and distinct virulence degrees. Read More

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January 2022

The Role of Dimorphism Regulating Histidine Kinase (Drk1) in the Pathogenic Fungus Cell Wall.

J Fungi (Basel) 2021 Nov 26;7(12). Epub 2021 Nov 26.

Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo, São Paulo 04023-062, Brazil.

Dimorphic fungi of the genus are the causative agents of paracoccidioidomycosis (PCM), an endemic disease in Latin America with a high incidence in Brazil. This pathogen presents as infective mycelium at 25 °C in the soil, reverting to its pathogenic form when inhaled by the mammalian host (37 °C). Among these dimorphic fungal species, dimorphism regulating histidine kinase (Drk1) plays an essential role in the morphological transition. Read More

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November 2021

Compulsory notification of paracoccidioidomycosis: A 14-year retrospective study of the disease in the state of Paraná, Brazil.

Mycoses 2022 Mar 3;65(3):354-361. Epub 2022 Jan 3.

Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, Brazil.

Background: Paracoccidioidomycosis, caused by fungi of the Paracoccidioides genus, is one of the most important endemic mycoses in Brazil. The disease is not of mandatory reporting in the country; however, some Brazilian states, such as Paraná, have included it on their local lists of public health-reportable diseases.

Objective: Describe the epidemiology of the positive paracoccidioidomycosis cases in the state of Paraná based on analysis of reporting forms and mortality data. Read More

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Exploring genetic diversity, population structure, and phylogeography in species using AFLP markers.

Stud Mycol 2021 Sep 30;100:100131. Epub 2021 Nov 30.

Laboratory of Emerging Fungal Pathogens, Department of Microbiology, Immunology, and Parasitology, Discipline of Cellular Biology, Federal University of São Paulo (UNIFESP), São Paulo, 04023062, Brazil.

Paracoccidioidomycosis (PCM) is a life-threatening systemic fungal infection acquired after inhalation of propagules from the environment. The main agents include members of the complex (phylogenetically-defined species S1, PS2, PS3, and PS4) and . DNA-sequencing of protein-coding loci (e. Read More

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September 2021

A case of paracoccidioidomycosis in a HIV-positive patient.

Indian J Sex Transm Dis AIDS 2021 Jul-Dec;42(2):182-184. Epub 2021 Oct 20.

Department of Pediatrics, Base Hospital Delhi Cantt, New Delhi, India.

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October 2021

Peptides derived from gp43, the most antigenic protein from Paracoccidioides brasiliensis, form amyloid fibrils in vitro: implications for vaccine development.

Sci Rep 2021 12 6;11(1):23440. Epub 2021 Dec 6.

Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro - Centro de Ciências da Saúde, Av. Carlos Chagas Filho 373, Bloco E, sala 42, Ilha do Fundão, Rio de Janeiro, RJ, CEP 21941-902, Brazil.

Fungal infection is an important health problem in Latin America, and in Brazil in particular. Paracoccidioides (mainly P. brasiliensis and P. Read More

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December 2021

PbGP43 Genotyping Using Paraffin-Embedded Biopsies of Human Paracoccidioidomycosis Reveals a Genetically Distinct Lineage in the Paracoccidioides brasiliensis Complex.

Mycopathologia 2022 Jun 6;187(2-3):157-168. Epub 2021 Dec 6.

Departamento de Ciências Farmacêuticas, Universidade Federal de São Paulo, Campus Diadema, São Paulo, SP, Brazil.

Paracoccidioidomycosis (PCM) is a systemic mycosis caused by a group of cryptic species embedded in the Paracoccidioides brasiliensis complex and Paracoccidioides lutzii. Four species were recently inferred to belong to the P. brasiliensis complex, but the high genetic diversity found in both human and environmental samples have suggested that the number of lineages may be higher. Read More

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