Front Cell Infect Microbiol 2022 3;12:903070. Epub 2022 Jun 3.
Laboratório de Biologia Molecular, Instituto de Ciências Biológicas, ICB II, Campus II, Universidade Federal de Goiás, Goiânia, Brazil.
Fungi of the genus are the etiological agents of the systemic mycosis paracoccidioidomycosis and, when in the host, they find a challenging environment that is scarce in nutrients and micronutrients, such as Fe, which is indispensable for the survival of the pathogen. Previous studies have shown that fungi of this genus, in response to Fe deprivation, are able to synthesize and capture siderophores (Fe chelators), use Fe-containing host proteins as a source of the metal, and use a non-canonical reductive pathway for Fe assimilation. Despite all of these findings, there are still gaps that need to be filled in the pathogen response to metal deprivation. Read More