Infect Genet Evol 2016 Sep 17;43:245-51. Epub 2016 May 17.
Department of Infectious and Parasitic Diseases, Faculdade de Medicina, Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 470 (IMT1, 1°. andar), 05403-000 São Paulo, SP, Brazil; Laboratory of Medical Investigation in Immunology (LIM-48), Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 470 (IMT2, térreo, sala 12), 05403-000 São Paulo, SP, Brazil. Electronic address:
Paracoccidioidomycosis (PCM) is a systemic chronic mycosis, endemic in Latin America, especially Brazil, and is the eighth leading cause of death among chronic and recurrent infectious diseases. PCM infection is characterized by the presence of Th1 immune response; the acute form, by a mixed Th2/Th9, while the chronic form is characterized by Th17/Th22 profiles. The occurrence and severity of human PCM may also be associated with genetic factors such as single nucleotide polymorphisms (SNP) on cytokines encoding genes. Read More