2,401 results match your criteria South American Blastomycosis


Endemic mycoses: epidemiology and diagnostic strategies.

Expert Rev Anti Infect Ther 2020 Jul 3. Epub 2020 Jul 3.

Dermatology service. Hospital General de México "Dr. Eduardo Liceaga".

Introduction: The global frequency of endemic mycoses has considerably increased, mainly due to environmental changes, population growth in endemic areas, and the increase in HIV-related immunosuppressed status. Among the most frequent endemic mycoses are coccidioidomycosis in semi-desert climates, and paracoccidioidomycosis, and histoplasmosis in tropical climates. The inoculum can enter the host through the airway or directly through the skin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14787210.2020.1792774DOI Listing

Propionate metabolism in a human pathogenic fungus: proteomic and biochemical analyses.

IMA Fungus 2020 5;11. Epub 2020 May 5.

Laboratório de Biologia Molecular, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Brazil.

Fungi of the complex spp. are thermodimorphic organisms that cause Paracoccidioidomycosis, one of the most prevalent mycoses in Latin America. These fungi present metabolic mechanisms that contribute to the fungal survival in host tissues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s43008-020-00029-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324963PMC

First report of paracoccidioidomycosis reactivation as a complication of immunosuppressive therapy for acute severe colitis in a caving enthusiast.

BMJ Case Rep 2020 Jul 2;13(7). Epub 2020 Jul 2.

Department of Gastroenterology, Weston Area Health NHS Trust, Weston-super-Mare, England, UK.

Treatment for ulcerative colitis often requires the administration of immunosuppressive therapy. Shortly after rescue therapy with infliximab for acute severe colitis, a patient who was also taking corticosteroids, azathioprine and adalimumab became rapidly unwell with atypical pneumonia, which did not respond to conventional antimicrobials. Re-examining the travel history revealed a prior caving trip to Costa Rica. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2019-234125DOI Listing

[Pulmonary mycosis in patients with diabetes mellitus. Clinical characteristics and risk factors].

Rev Iberoam Micol 2020 Jun 29. Epub 2020 Jun 29.

Dirección de Investigación, Hospital General de México "Dr. Eduardo Liceaga", Ciudad de México, México.

Background: Diabetes mellitus is a public health problem in Mexico, and the trend of the disease is increasing. From 2000 to 2017, 7.32 million new cases were diagnosed, with pulmonary mycoses being one of the most serious complications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.riam.2020.04.002DOI Listing

Hippocampal sclerosis in paracoccidioidomycosis.

Arq Neuropsiquiatr 2020 Jun;78(6):384

Universidade Federal do Espírito Santo, Hospital Universitário Cassiano Antônio de Moraes, Departamento de Doenças Infecciosas, Vitória ES, Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/0004-282X20200015DOI Listing

Metabolomics and Machine Learning Approaches Combined in Pursuit for More Accurate Paracoccidioidomycosis Diagnoses.

mSystems 2020 Jun 30;5(3). Epub 2020 Jun 30.

Innovare Biomarkers Laboratory, School of Pharmaceutical Sciences, University of Campinas, Campinas, SP, Brazil

Brazil and many other Latin American countries are areas of endemicity for different neglected diseases, and the fungal infection paracoccidioidomycosis (PCM) is one of them. Among the clinical manifestations, pneumopathy associated with skin and mucosal lesions is the most frequent. PCM definitive diagnosis depends on yeast microscopic visualization and immunological tests, but both present ambiguous results and difficulty in differentiating PCM from other fungal infections. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/mSystems.00258-20DOI Listing

Nitrogen Catabolite Repression in members of Paracoccidioides complex.

Microb Pathog 2020 Jun 22:104281. Epub 2020 Jun 22.

Laboratório de Biologia Molecular, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Goiás, Brazil. Electronic address:

Paracoccidioides complex is a genus that comprises pathogenic fungi which are responsible by systemic disease Paracoccidioidomycosis. In host tissues, pathogenic fungi need to acquire nutrients in order to survive, making the uptake of nitrogen essential for their establishment and dissemination. Nitrogen utilization is employed by the alleviation of Nitrogen Catabolite Repression (NCR) which ensures the use of non-preferential or alternative nitrogen sources when preferential sources are not available. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.micpath.2020.104281DOI Listing

Effect of Nitrosative Stress on the -Nitroso-Proteome of .

Front Microbiol 2020 4;11:1184. Epub 2020 Jun 4.

Department of Microbiology, Immunology and Parasitology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.

The fungi and are the causative agents of paracoccidioidomycosis (PCM), a systemic mycosis endemic to Latin America. This fungus is considered a facultative intracellular pathogen that is able to survive and replicate inside macrophages. The survival of the fungus during infection depends on its adaptability to various conditions, such as nitrosative/oxidative stress produced by the host immune cells, particularly alveolar macrophages. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2020.01184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287035PMC

Copper overload in Paracoccidioides lutzii results in the accumulation of ergosterol and melanin.

Microbiol Res 2020 Jun 11;239:126524. Epub 2020 Jun 11.

Laboratório de Biologia Molecular, Instituto de Ciências Biológicas II, Campus II, Universidade Federal de Goiás, Goiânia, Goiás, Brazil. Electronic address:

Paracoccidioidomycosis is a highly prevalent systemic mycosis in Latin America, caused by fungi of the genus Paracoccidioides. Copper is essential for eukaryotes and bacteria. This micronutrient is used in many vital biochemical processes, although metal excess levels can be toxic for organisms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.micres.2020.126524DOI Listing

Synthesis and antifungal activity of new hybrids pyrimido[4,5-d]pyridazinone-N-acylhydrazones.

Bioorg Med Chem Lett 2020 Jul 7;30(14):127244. Epub 2020 May 7.

Department of Chemistry, State University of Maringá, Maringá, PR, Brazil. Electronic address:

Paracoccidioidomycosis is an endemic mycosis in Latin America for which there is a high mortality rate and limited treatment options. There are no specific drugs to treat the systemic disease. Thus, there is a need for further studies focused on the development of specific drugs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2020.127244DOI Listing

Characterization of a Paracoccidioides spp. strain from southeastern Brazil genotyped as Paracoccidioides restrepiensis (PS3) and review of this phylogenetic species.

Genet Mol Biol 2020 29;43(2):e20190201. Epub 2020 May 29.

Universidade de São Paulo (USP), Faculdade de Medicina de Ribeirão Preto (FMRP), Departamento de Clínica Médica, Ribeirão Preto, SP, Brazil.

Phylogenetic species of Paracoccidioides brasiliensis complex (S1a and S1b, PS2, PS3, and PS4) and Paracoccidioides lutzii are agents of paracoccidioidomycosis, an endemic fungal disease in Latin America. P. restrepiensis (PS3 genotype) was classified as monophyletic and geographically restricted to Colombia and neighboring territories. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/1678-4685-GMB-2019-0201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268198PMC

Adrenal paracoccidioidomycosis

Biomedica 2020 05 1;40(Supl. 1):20-22. Epub 2020 May 1.

Departamento de Patología, Universidad de Antioquia, Medellín, Colombia.

Primary adrenal insufficiency is a defect in glucocorticoid, mineralocorticoid and sexual androgens production. Patients with this disorder have low cortisol levels and aldosterone deficiency with concomitant hyponatremia and hyperkalemia. The most common etiology of this disease is the production of antibodies against the enzyme 21 hydroxylase. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7705/biomedica.4844DOI Listing

Prostatic involvement in disseminated paracoccidioidomycosis: An unusual presentation mimicking malignant neoplasm.

Med Mycol Case Rep 2020 Jun 4;28:46-48. Epub 2020 May 4.

University Center of Maringá, Guedner Avenue, 1610, Maringá, Paraná, 87.050-390, Brazil.

Paracoccidioidomycosis is a granulomatous fungal infection, endemic to Latin America, which has great economic impact. Prostatic involvement is rare and can simulate other conditions, which poses a diagnostic challenge for the clinician. This article describes the report of a case of disseminated paracoccidioidomycosis with prostatic involvement, initially confused with prostatic adenocarcinoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mmcr.2020.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225591PMC

Paracoccidiodomycosis lung reactivation in a patient with signet-ring cell gastric adenocarcinoma after chemotherapy: Case report.

IDCases 2020 23;20:e00769. Epub 2020 Apr 23.

Infectious Diseases Unit, Guillermo Almenara Irigoyen National Hospital - EsSalud, Lima, Peru.

Although the relationship between paracoccidioidomycosis (PCM) and solid tumors has been described more than 80 years ago, reports of PCM and gastric cancer are rare. PCM can present before or concomitantly with the diagnosis of cancer, and its clinical presentation may rise the suspicion of malignancies or be part of reactivation by immunosuppression. We present the case of a 52-year-old Peruvian man with a signet-ring cell (SRC) gastric adenocarcinoma who after 6 chemotherapy sessions with FLOT (docetaxel, oxaliplatin, leucovorin, 5-fluorouracil) presented rapidly growing lung nodules. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.idcr.2020.e00769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215172PMC

Expression of Hsp60 and its cell location in Paracoccidioides brasiliensis.

Rev Inst Med Trop Sao Paulo 2020 11;62:e29. Epub 2020 May 11.

Departamento de Biologia, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.

Paracoccidioides species cause paracoccidioidomycosis (PCM), a systemic mycosis highly prevalent in Brazil. Therapy of PCM has some issues that make studies for new therapeutic and vaccine targets relevant, such as the P. brasiliensis 60-kDa-heat-shock protein (PbHsp60), an immunogenic antigen that induces protection in experimental mice infection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/s1678-9946202062029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232959PMC

Genomic diversity of the human pathogen Paracoccidioides across the South American continent.

Fungal Genet Biol 2020 Jul 20;140:103395. Epub 2020 Apr 20.

Universidad Nacional del Nordeste, Resistencia, Chaco, Argentina. Electronic address:

Paracoccidioidomycosis (PCM) is a life-threatening systemic mycosis widely reported in the Gran Chaco ecosystem. The disease is caused by different species from the genus Paracoccidioides, which are all endemic to South and Central America. Here, we sequenced and analyzed 31 isolates of Paracoccidioides across South America, with particular focus on isolates from Argentina and Paraguay. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fgb.2020.103395DOI Listing

Paracoccin: Purification and Validation of Its Lectin and Enzymatic Properties.

Methods Mol Biol 2020 ;2132:139-149

Laboratory of Immunochemistry and Glycobiology, Department of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto School of Medicine University of São Paulo (FMRP/USP), Ribeirão Preto, SP, Brazil.

Studies on the effects of components derived from the human pathogenic fungi Paracoccidioides brasiliensis have identified paracoccin (PCN), as a bifunctional protein with lectin (GlcNAc-binding) and enzymatic (chitinase) activities, able to induce modulation of host immune response. Endogenous PCN acts as a fungal virulence factor, whereas exogenous purified PCN, administered to the host, confers protective immunity in a murine model of paracoccidioidomycosis. The immunomodulation induced by purified-PCN injection has characterized it as an agent applicable in the therapy and vaccine against paracoccidioidomycosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-0716-0430-4_14DOI Listing
January 2020

Opportunistic tropical infections in immunosuppressed patients.

Best Pract Res Clin Rheumatol 2020 Apr 13:101509. Epub 2020 Apr 13.

Programa de Pós-graduação em Ciências Médicas, Programa de Pós-Graduação em Medicina Tropical, SGAN 605. Av. L2 Norte, CEP: 70910-900, Brasília, Distrito Federal, Brazil. Electronic address:

Autoimmune and autoinflammatory diseases are associated with severe morbidity, and represent an impactful health and economic burden worldwide. The treatment of these diseases can include a course with detrimental side effects. Immunosuppression increases the risk of opportunistic infections, but in some cases, the abrupt discontinuation of these medications can result in immune reconstitution inflammatory syndrome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.berh.2020.101509DOI Listing

A Brazilian male with typical oral and pulmonary paracoccidioidomycosis.

Med J Islam Repub Iran 2019 21;33:145. Epub 2019 Dec 21.

State University of Health Sciences of Alagoas, Brazil.

An autochthonous case of paracoccidioidomycosis was reported in a city of north Iran. This condition is a well-known endemic fungal infection highly prevalent in Latin American countries, with an incidence of 1 to 3.7 cases per 100. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.34171/mjiri.33.145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137875PMC
December 2019

Delayed Relapse of Paracoccidioidomycosis in the Central Nervous System: A Case Report.

Open Forum Infect Dis 2020 Apr 2;7(4):ofaa077. Epub 2020 Mar 2.

Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Paracoccidioidomycosis is a dimorphic fungal infection endemic in Latin America. We report a patient with a history of pulmonary paracoccidioidomycosis who presented with relapsed disease in the central nervous system 4 years after initial treatment. We review current treatment strategies for paracoccidioidomycosis and neuroparacoccidioidomycosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ofid/ofaa077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112725PMC

Frequency of Invasive Fungal Disease in Adults: Experience of a Specialized Laboratory in Medellín, Colombia (2009-2015).

J Fungi (Basel) 2020 Mar 20;6(1). Epub 2020 Mar 20.

Medical and Experimental Mycology Unit, Corporación para Investigaciones Biológicas (CIB), Medellín 050036, Colombia.

Invasive fungal diseases (IFD) contribute significantly to worldwide morbidity and mortality, but their frequency is not well-described in some countries. The present work describes the frequency of IFD in a specialized laboratory in Colombia. A retrospective, descriptive study was implemented between March 2009 and December 2015. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jof6010039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151061PMC

Diagnosis and treatment of primary paracoccidioidomycosis in oral mucosa.

Dermatol Ther 2020 May 8;33(3):e13314. Epub 2020 Apr 8.

Dental School, University Brasil, Fernandópolis, São Paulo, Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dth.13314DOI Listing

Paracoccidioidomycosis: Endobronchial Involvement in a Rare Disease in Europe.

Arch Bronconeumol 2020 Mar 6. Epub 2020 Mar 6.

Anatomical Pathology Department, Hospital Central do Funchal, Portuga.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arbres.2020.01.017DOI Listing

Medication association and immunomodulation: An approach in fungal diseases and in particular in the treatment of paracoccidioidomycosis.

Acta Trop 2020 Jun 2;206:105412. Epub 2020 Mar 2.

Microbiology and Immunology Department, Biomedical Sciences Institute, Federal University of Alfenas, Alfenas, MG, Brazil. Electronic address:

Fungal infections have been increasing in recent decades, mainly affecting immunocompromised individuals, although certain mycoses, such as paracoccidioidomycosis (PCM), infect immunologically competent individuals. The major problems observed regarding fungal diseases are inadequate diagnosis, prolonged treatment time, the reduced number of drugs available for treatment, in addition to the fact that there are no vaccines for clinical use. Drug combination in order to immunomodulate the immune response is a new strategy used for the treatment of mycoses, since it is difficult to develop new antifungal drugs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.actatropica.2020.105412DOI Listing

Immunoproteomic Approach of Extracellular Antigens From Species Reveals Exclusive B-Cell Epitopes.

Front Microbiol 2019 28;10:2968. Epub 2020 Jan 28.

Laboratório de Biologia Molecular, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Brazil.

Fungi of the genus are the etiological agents of paracoccidioidomycosis (PCM), a systemic mycosis restricted to the countries of Latin America. Currently, the complex is represented by , , , , and . Even with advances in techniques used for diagnosing fungal diseases, high rates of false-positive results for PCM are still presented. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2019.02968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015227PMC
January 2020

Minimum concentration of Amphotericin B in serum according to the formulation, dose, and daily or prolonged intermittent therapeutic regimen.

Rev Soc Bras Med Trop 2020 7;53:e20180463. Epub 2020 Feb 7.

Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Clínica Médica, Ribeirão Preto, SP, Brasil.

Introduction: The therapeutic efficacy of daily amphotericin B infusion is related to its maximum concentration in blood; however, trough levels may be useful in intermittent regimens of this antifungal drug.

Methods: : High performance liquid chromatography (HPLC) was used to determine the minimum concentration (Cmin) of amphotericin B in the serum of patients receiving deoxycholate (D-Amph) or liposomal amphotericin B (L-AmB) for the treatment of cryptococcal meningitis (n=28), histoplasmosis (n=8), paracoccidioidomycosis (n=1), and leishmaniasis (n=1).

Results: Daily use of D-Amph 30 to 50 mg or L-AmB 50 mg resulted in a similar Cmin, but a significant increase ocurred with L-AmB 100 mg/day. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/0037-8682-0463-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083383PMC

Antifungal activity of 2'-hydroxychalcone loaded in nanoemulsion against spp.

Future Microbiol 2020 Jan 11;15:21-33. Epub 2020 Feb 11.

Universidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquara, Proteomics Center, Mycology Laboratory, Araraquara, SP, Brazil.

This study aimed to evaluate the activity of 2'-hydroxychalcone-loaded in nanoemulsion (NLS + 2'chalc), the cytotoxic effect and toxicity against and using a zebrafish model. Preparation and physical-chemical characterization of nanoemulsion (NLS) and NLS + 2'chalc were performed. MIC and minimum fungicide concentration, cytotoxicity and toxicity were also evaluated in the model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/fmb-2019-0095DOI Listing
January 2020

ACUTE PULMONARY PARACOCCIDIOIDOMYCOSIS IN A TRAVELER TO MEXICO.

J Travel Med 2020 Feb 10. Epub 2020 Feb 10.

National Referral Centre for Tropical Diseases, Infectious Diseases Department, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jtm/taaa018DOI Listing
February 2020

Thinking in paracoccidioidomycosis: a delayed diagnosis of a neglected tropical disease, case report and review of clinical reports and eco-epidemiologic data from Colombia since the 2000.

BMC Infect Dis 2020 Feb 10;20(1):119. Epub 2020 Feb 10.

Universidad Tecnológica de Pereira, Pereira, Colombia.

Background: Paracoccidioidomycosis is a neglected tropical disease, endemic in several countries of South America including Colombia. We report a case of a patient with Chronic Multifocal Paracoccidioidomycosis with long-standing symptoms and a delayed diagnosis caused by several barriers to achieve it. We did a review of the papers published in Colombia about this disease, focusing in clinical data and eco-epidemiology with the finding of a lack of new information on this topic since the 2000 in our region. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12879-020-4864-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011283PMC
February 2020

Re-drawing the Maps for Endemic Mycoses.

Mycopathologia 2020 Feb 10. Epub 2020 Feb 10.

Division of Infectious Diseases, Department of Internal Medicine, University of Kansas, Kansas City, KS, USA.

Endemic mycoses such as histoplasmosis, coccidioidomycosis, blastomycosis, paracoccidioidomycosis, and talaromycosis are well-known causes of focal and systemic disease within specific geographic areas of known endemicity. However, over the past few decades, there have been increasingly frequent reports of infections due to endemic fungi in areas previously thought to be "non-endemic." There are numerous potential reasons for this shift such as increased use of immune suppressive medications, improved diagnostic tests, increased disease recognition, and global factors such as migration, increased travel, and climate change. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11046-020-00431-2DOI Listing
February 2020

New Insights on Pulmonary Paracoccidioidomycosis.

Semin Respir Crit Care Med 2020 02 30;41(1):53-68. Epub 2020 Jan 30.

Section of Infectious Diseases, Department of Medicine, Hospital Universitário Cassiano Antônio de Moraes, Federal University of Espírito Santo, Espírito Santo, Brazil.

Paracoccidioidomycosis (PCM) is one of the most relevant systemic endemic mycoses in Latin American countries, especially in South American countries, with endemic and hyperendemic areas. The real burden of PCM may be underestimated because of a lack of compulsory case notification. Recent phylogenetic data revealed that comprises several cryptic species including and . Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0039-3400544DOI Listing
February 2020

ADRENAL INSUFFICIENCY CAUSED BY PARACOCCIDIOIDOMYCOSIS: THREE CASE REPORTS AND REVIEW.

AACE Clin Case Rep 2019 Jul-Aug;5(4):e238-e243. Epub 2019 Mar 13.

Objective: Fungal infections can affect the adrenal glands, causing primary adrenal insufficiency (PAI). Although endemic to South America, paracoccidioidomycosis (PCM), which can lead to PAI, has gained global relevance with the increase in international travel and migration.

Methods: The present report describes 3 patients with PAI caused by PCM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4158/ACCR-2018-0632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873835PMC

Association between IL-27 and Tr1 cells in severe form of paracoccidioidomycosis.

Cytokine 2020 Mar 2;127:154962. Epub 2020 Jan 2.

Department of Clinical Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil. Electronic address:

Interleukin-27, a cytokine of the IL-12 family, is secreted by antigen-presenting cells such as macrophages and dendritic cells (DCs). Recent studies suggest an anti-inflammatory role for IL-27 by inducing IL-10 producing Tr1 cells capable of inhibiting Th1 and Th17 type responses. Our study aimed to investigate the involvement of IL-27 and Tr1 cells in the immunomodulation of paracoccidioidomycosis (PCM), the most prevalent systemic mycosis in Brazil. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cyto.2019.154962DOI Listing
March 2020
2.664 Impact Factor

43 kDa Glycoprotein (gp43) from Induced IL-17A and PGE2 Production by Human Polymorphonuclear Neutrophils: Involvement of TLR2 and TLR4.

J Immunol Res 2019 26;2019:1790908. Epub 2019 Nov 26.

Laboratory of Immunopathology and Infectious Agents (LIAI), Experimental Research Unit (UNIPEX), Medical School of Botucatu (FMB), São Paulo State University (UNESP), Av. Professor Montenegro, s/n, Distrito de Rubião Júnior, 18618-687 Botucatu, São Paulo, Brazil.

The glycoprotein gp43 is the major antigenic/diagnostic component of , one of the etiologic agents of paracoccidioidomycosis (PCM). Gp43 has protective roles in mice, but due to adhesive properties, this glycoprotein has also been associated with immune evasion mechanisms. The present study evaluated gp43 interaction in vitro with Toll-like receptors 2 and 4 (TLR2 and TLR4) present in polymorphonuclear neutrophils (PMNs) from healthy human individuals and the consequent modulation of the immune response through the expression and release of cytokines and eicosanoids. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/1790908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899308PMC

Dynamics of plasma micronutrient concentrations and their correlation with serum proteins and thyroid hormones in patients with paracoccidioidomycosis.

PLoS One 2019 26;14(12):e0226609. Epub 2019 Dec 26.

Faculty of Medicine- FAMED, Center for Biological and Health Sciences- CCBS, Federal University of Mato Grosso do Sul, Mato Grosso do Sul, Campo Grande, Brazil.

Minerals, such as zinc, copper, and iron are reported to play roles in chronic infectious diseases; however, their role in paracoccidioidomycosis (PCM) remains unknown. This study aimed to examine the micronutrient dynamics and their correlation with serum proteins and thyroid hormones in patients with PCM. In 14 patients with PCM and 10 healthy subjects, we evaluated the body mass index (BMI) along with serum levels of hemoglobin, iron, ferritin, zinc, copper, magnesium, albumin, globulin, thyroid stimulating hormone (TSH), thyroxine (free T4), and triiodothyronine (T3). Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0226609PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932777PMC

Antifungal Activity, Toxicity, and Membranolytic Action of a Mastoparan Analog Peptide.

Front Cell Infect Microbiol 2019 6;9:419. Epub 2019 Dec 6.

Department of Clinical Analysis, School of Pharmaceutical Sciences, São Paulo State University-UNESP, Araraquara, Brazil.

Invasive fungal infections, such as cryptococcosis and paracoccidioidomycosis are associated with significant rates of morbidity and mortality. Cryptococcosis, caused by , is distributed worldwide and has received much attention as a common complication in patients with HIV. Invasive fungal infections are usually treated with a combination of amphotericin B and azoles. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fcimb.2019.00419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908851PMC
December 2019

Chronic progressive pulmonary paracoccidioidomycosis in a female immigrant from Venezuela.

Ther Adv Respir Dis 2019 Jan-Dec;13:1753466619894913

Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany.

Paracoccidioidomycosis (PCM) is a fungal infection caused by and . It is endemic to South and Central America. While PCM frequently remains latent, the disease can reactivate years after the initial infection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1753466619894913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918496PMC

Antifungal activity of Copaíba resin oil in solution and nanoemulsion against Paracoccidioides spp.

Braz J Microbiol 2020 Mar 12;51(1):125-134. Epub 2019 Dec 12.

Laboratory of Molecular Biology, Institute of Biological Sciences, Federal University of Goiás, Goiânia, Goiás, 74690-900, Brazil.

Paracoccidioidomycosis (PCM) is a disease caused by fungi of the genus Paracoccidioides. The disease is responsible for high rates of premature deaths and socioeconomic repercussions. The limitations of antifungal agents against PCM have motivated the search for new compounds. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s42770-019-00201-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058720PMC

[Skin lesion, dysphonia and micronodulillary infiltrates in a rural worker].

Medicina (B Aires) 2019 ;79(6):526

VI Cátedra de Medicina Interna, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Argentina. E-mail:

View Article

Download full-text PDF

Source

First report of Paracoccidioides brasiliensis infection in fish.

Med Mycol 2019 Nov 27. Epub 2019 Nov 27.

Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, PR 445 Km 380, Londrina, Paraná, Brazil.

The thermodimorphic fungus Paracoccidioides brasiliensis is the etiological agent of paracoccidioidomycosis (PCM), a deep mycosis endemic in Latin American countries that affects mainly male rural workers. Infection by P. brasiliensis has also been reported in several species of terrestrial animals; however, the capacity of the fungus to infect aquatic organisms is poorly known. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/mmy/myz120DOI Listing
November 2019

Enhanced expression of NLRP3 inflammasome components by monocytes of patients with pulmonary paracoccidioidomycosis is associated with smoking and intracellular hypoxemia.

Microbes Infect 2020 04 23;22(3):137-143. Epub 2019 Nov 23.

São Paulo State University (UNESP), Medical School, Botucatu, SP, Brazil; Federal University of Mato Grosso do Sul (UFMS), Medical School, Campo Grande, MS, Brazil. Electronic address:

Paracoccidioidomycosis (PCM) is a systemic mycosis caused by thermally dimorphic fungi of the genus Paracoccidioides that affects predominantly 30-60-year-old male rural workers. The main clinical forms of the disease are acute/subacute, chronic (CF); almost all CF patients develop pulmonary fibrosis, and they also exhibit emphysema due to smoke. An important cytokine in this context, IL-1β, different from the others, is produced by an intracellular multimolecular complex called inflammasome that is activated by pathogens and/or host signs of damage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.micinf.2019.11.001DOI Listing

Down-regulation of TUFM impairs host cell interaction and virulence by Paracoccidioides brasiliensis.

Sci Rep 2019 11 20;9(1):17206. Epub 2019 Nov 20.

Faculdade de Ciências Farmacêuticas, UNESP - Univ Estadual Paulista, Campus Araraquara, Departamento de Análises Clínicas, Laboratório de Micologia Clinica, São Paulo, Brazil.

The genus Paracoccidioides consist of dimorphic fungi geographically limited to the subtropical regions of Latin America, which are responsible for causing deep systemic mycosis in humans. However, the molecular mechanisms by which Paracoccidioides spp. causes the disease remain poorly understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-51540-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868139PMC
November 2019
5.078 Impact Factor

Paracoccidioides species present distinct fungal adherence to epithelial lung cells and promote different IL-8 secretion levels.

Med Microbiol Immunol 2020 Feb 31;209(1):59-67. Epub 2019 Oct 31.

Department of Microbiology, Immunology, and Parasitology, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Botucatu, 862-Ed. Antônio C. M. Paiva-6 andar, São Paulo, SP, 04023-062, Brazil.

Fungi that belong to the genus Paracoccidioides are the etiologic agents of paracoccidioidomycosis, a human systemic mycosis, which occurs in Latin America. Epithelial cell is one of the first cells that interact with these fungi and responds by secreting inflammatory mediators such as cytokines. In the present study, we demonstrate that yeasts of different isolates of Paracoccidioides brasiliensis (Pb18 and Pb03) and Paracoccidioides lutzii (Pb01) distinctly promoted interleukin (IL)-8 secretion by the lung epithelial cell line A549. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00430-019-00639-0DOI Listing
February 2020
1 Read

New inhibitors of homoserine dehydrogenase from Paracoccidioides brasiliensis presenting antifungal activity.

J Mol Model 2019 Oct 25;25(11):325. Epub 2019 Oct 25.

Department of Technology, Universidade Estadual de Maringá, Campus Umuarama. Av. Ângelo Moreira da Fonseca, 1800, Umuarama, PR, 87506-370, Brazil.

Paracoccidioidomycosis (PCM) is a systemic mycosis caused by fungi of the genus Paracoccidioides spp., which mainly affects workers in rural regions of Latin America. Although the antifungal agents currently available for the treatment of PCM are effective in controlling the disease, many months are needed for healing, making the side effects and drug interactions relevant. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00894-019-4221-2DOI Listing
October 2019
5 Reads

Paracoccidioidomycosis in a child: exuberant presentation due to the inadvertent use of systemic corticosteroids.

An Bras Dermatol 2019 17;94(4):470-472. Epub 2019 Oct 17.

Laboratory of Pathology, Santa Casa de São Paulo - São Paulo, SP, Brazil.

Paracoccidioidomycosis is a fungal infection that occurs in immunocompetent patients and are classified into two forms: the acute-subacute form, predominantly in young patients, and the chronic adult form that may present classic ulcerated lesions to rare sarcoid ones. We present the case of a boy whose infection began with sarcoid lesions but, after being mistakenly diagnosed with cutaneous sarcoidosis and treated (for three years) with prednisone, developed painful ulcerations throughout the body. After the correct diagnosis, with evidence of the fungus in histopathological and mycological examinations, the patient was properly treated with itraconazole for eight months and evolved with total remission of the disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/abd1806-4841.20198355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007017PMC
October 2019
1 Read

Oral paracoccidioidomycosis in a non-endemic region from Brazil: A short case series.

J Clin Exp Dent 2019 Oct 1;11(10):e865-e870. Epub 2019 Oct 1.

DDS, PhD, Professor, School of Dentistry, Oral Pathology Unit, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.

Background: Although the paracoccidioidomycosis (PCM) is endemic in Brazil, the occurrence in most states from the North and Northeastern Brazil is very unusual. The aim of this study was to evaluate the clinicopathologic features of a case series of oral PCM in a non-endemic region from Brazil (Northeastern region), discussing the clinical and histopathological differential diagnoses of the oral manifestations of the disease.

Material And Methods: Between 2000 and 2017, all cases of oral PCM were retrieved from the Oral Pathology Laboratory, Universidade Federal de Pernambuco, located at Northeastern Brazil. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4317/jced.56199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797468PMC
October 2019
2 Reads

Evaluation of a Histoplasma antigen lateral flow assay for the rapid diagnosis of progressive disseminated histoplasmosis in Colombian patients with AIDS.

Mycoses 2020 Feb 27;63(2):139-144. Epub 2019 Nov 27.

Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA.

Background: Progressive disseminated histoplasmosis (PDH) is an important cause of mortality in persons living with HIV (PLHIV), especially in countries where patients have limited access to antiretroviral therapies and diagnostic testing.

Objective: A lateral flow assay (LFA) to detect Histoplasma capsulatum antigen in serum developed by MiraVista was evaluated.

Methods: We tested 75 serum samples: 24 from PLHIV and culture-proven PDH and 51 from PLHIV with other fungal and bacterial infections as well as people without HIV. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.13023DOI Listing
February 2020
1 Read

An autochthonous case of paracoccidioidomycosis in a new area of Ceara State, Northeastern Brazil.

Rev Inst Med Trop Sao Paulo 2019 10;61:e58. Epub 2019 Oct 10.

Hospital São José de Doenças Infecciosas, Fortaleza, Ceará, Brazil.

The largest endemic areas of paracoccidioidomycosis (PCM) in Brazil comprise the humid agricultural regions of the Southeast, South, and, recently, the Midwest and North regions. The Ceara State, located in the Brazilian Northeast region, presents semi-arid climate in most of its territory, characterized by high temperatures, scarce vegetation and low humidity. The objective of the present study was to describe a new autochthonous case of paracoccidioidomycosis from a distinct area of Ceara and review the characteristics of PCM occurrence in Northeastern Brazil. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/S1678-9946201961058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792362PMC
October 2019
3 Reads