2,315 results match your criteria South American Blastomycosis


Clinical features and genetic background of the sympatric species Paracoccidioides brasiliensis and Paracoccidioides americana.

PLoS Negl Trop Dis 2019 Apr 15;13(4):e0007309. Epub 2019 Apr 15.

Infectious Dermatology Clinical Research Laboratory, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro, Rio de Janeiro, Brazil.

Introduction: The agents of paracoccidioidomycosis, historically identified as Paracoccidioides brasiliensis, are in fact different phylogenetic species. This study aims to evaluate associations between Paracoccidioides phylogenetic species and corresponding clinical data.

Methods: Paracoccidioides strains from INI/Fiocruz patients (1998-2016) were recovered. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0007309DOI Listing

Identification and characterization of Paracoccidioides lutzii proteins interacting with macrophages.

Microbes Infect 2019 Apr 2. Epub 2019 Apr 2.

Laboratório de Biologia Molecular, Instituto de Ciências Biológicas, Universidade Federal de Goiás, 74001-970, Goiânia, Goiás, Brazil. Electronic address:

Paracoccidioidomycosis (PCM), caused by thermodimorphic fungi of the Paracoccidioides genus, is a systemic disorder that involves the lungs and other organs. The adherence of pathogenic microorganisms to host tissues is an essential event in the onset of colonization and spread. The host-pathogen interaction is a complex interplay between the defense mechanisms of the host and the efforts of pathogenic microorganisms to colonize it. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.micinf.2019.03.002DOI Listing
April 2019
1 Read

Metabolic Peculiarities of Dimorphism as Demonstrated by iTRAQ Labeling Proteomics.

Front Microbiol 2019 20;10:555. Epub 2019 Mar 20.

Laboratório de Biologia Molecular, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Brazil.

Paracoccidioidomycosis (PCM), a systemic mycosis with a high incidence in Latin America, is caused by thermodimorphic fungi of the genus. The contact with host occurs by the inhalation of conidia or mycelial propagules which once reaching the pulmonary alveoli differentiate into yeast cells. This transition process is vital in the pathogenesis of PCM allowing the fungus survival in the host. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2019.00555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436475PMC
March 2019
1 Read

Involvement of the Dectin-1 Receptor upon the Effector Mechanisms of Human Phagocytic Cells against .

J Immunol Res 2019 6;2019:1529189. Epub 2019 Feb 6.

São Paulo State University (UNESP), Medical School of Botucatu, Laboratory of Immunopathology and Infectious Agents - LIAI, UNIPEX - Experimental Research Unity, Sector 5, Botucatu SP, Brazil.

Paracoccidioidomycosis (PCM), a systemic mycosis endemic in Latin America, occurs after inhalation of mycelial components of spp. When the fungus reaches the lungs and interacts with the alveolar macrophages and other cells, phagocytic cells such as neutrophils and monocytes are immediately recruited to the injured site. The interaction between surface molecules of pathogens and homologous receptors, present on the surface membrane of phagocytes, modulates the innate immune cell activation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/1529189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381556PMC
February 2019
1 Read

Clinical and microbiological characteristics of paracoccidioidomycosis in patients with AIDS in Buenos Aires, Argentina.

Med Mycol 2019 Mar 15. Epub 2019 Mar 15.

Mycology Unit of the Infectious Diseases Hospital F.J. Muñiz, Reference Center of Mycology of Buenos Aires city, Argentina.

Paracoccidioidomycosis (Pm) is a systemic disease, endemic in the American continent. There are two different clinical forms, the infant-juvenile or subacute form (PmS) and the chronic adult form (PmC). The human immunodeficiency virus (HIV) associated paracoccidioidomycosis (PmHIV) shares characteristics with both of the previously mentioned forms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/mmy/myz021DOI Listing
March 2019
1 Read

Paracoccidioidomycosis in the external ear.

IDCases 2019 14;15:e00504. Epub 2019 Feb 14.

Academic in Medicine of the Federal University of Goiás, Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.idcr.2019.e00504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383324PMC
February 2019

Proteomic Analysis of During Infection of Alveolar Macrophages Primed or Not by Interferon-Gamma.

Front Microbiol 2019 5;10:96. Epub 2019 Feb 5.

Laboratório de Biologia Molecular, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Brazil.

Although members of the complex are not obligate intracellular pathogens, they present the ability to survive and multiply inside epithelial cells and phagocytes of mammals, which may favor the spread of the fungus in host tissues. Macrophages resident in the lung are the first line of defense against paracoccidioidomycosis (PCM), presenting mechanisms to control the pathogen dissemination through the granuloma formation or eliminating the fungus through phagocytosis. Phagocytosis triggers an oxidative burst, in which there is an increase in the production of toxic elements, derived from oxygen and nitrogen. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fmicb.2019.00096
Publisher Site
http://dx.doi.org/10.3389/fmicb.2019.00096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371752PMC
February 2019
7 Reads

Cross-talk between the Ras GTPase and the Hog1 survival pathways in response to nitrosative stress in Paracoccidioides brasiliensis.

Nitric Oxide 2019 May 14;86:1-11. Epub 2019 Feb 14.

Department of Pharmaceutical Sciences, Universidade Federal de São Paulo, Campus Diadema, SP, Brazil; Department of Microbiology, Immunology and Parasitology, Escola Paulista de Medicina, Universidade Federal de São Paulo, SP, Brazil. Electronic address:

Paracoccidioides brasiliensis is a temperature-dependent dimorphic fungus that cause paracoccidioidomycosis (PCM), the major systemic mycosis in Latin America. The capacity to evade the innate immune response of the host is due to P. brasiliensis ability to respond and to survive the nitrosative stress caused by phagocytic cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.niox.2019.02.002DOI Listing
May 2019
1 Read

TLR3 Is a Negative Regulator of Immune Responses Against .

Front Cell Infect Microbiol 2018 10;8:426. Epub 2019 Jan 10.

Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas da Universidade de São Paulo, São Paulo, Brazil.

Toll-like receptors (TLRs) comprise the best-characterized pattern-recognition receptor (PRR) family able to activate distinct immune responses depending on the receptor/adaptor set assembled. TLRs, such as TLR2, TLR4 and TLR9, and their signaling were shown to be important in infections. However, the role of the endosomal TLR3 in experimental paracoccidioidomycosys remains obscure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fcimb.2018.00426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335947PMC
January 2019

Endemic pulmonary fungal diseases in immunocompetent patients: an emphasis on thoracic imaging.

Expert Rev Respir Med 2019 Mar 31;13(3):263-277. Epub 2019 Jan 31.

a Department of Radiology , Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.

Introduction: Systemic endemic mycoses are prevalent in specific geographical areas of the world and are responsible for high rates of morbidity and mortality in these populations, and in immigrants and travelers returning from endemic regions. The most common fungal infections that can affect the lungs of immunocompetent patients include histoplasmosis, coccidioidomycosis, paracoccidioidomycosis, blastomycosis, sporotrichosis, aspergillosis, and cryptococcosis. Diagnosis and management of these diseases remain challenging, especially in non-endemic areas due to the lack of experience. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2019.1571914DOI Listing
March 2019
4 Reads

New 4-methoxy-naphthalene derivatives as promisor antifungal agents for paracoccidioidomycosis treatment.

Future Microbiol 2019 Feb 21;14:235-245. Epub 2019 Jan 21.

Department of Chemistry, State University of Maringá, Maringá, PR, Brazil.

Aim: Novel 4-methoxy-naphthalene derivatives were synthesized based on hits structures in order to evaluate the antifungal activity against Paracoccidioides spp.

Methods: Antifungal activity of compounds was evaluated against P. brasiliensis and most promising compounds 2 and 3 were tested against eight clinically important fungal species. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/fmb-2018-0276DOI Listing
February 2019
4 Reads

Oral Biopsy for Early Diagnosis of Paracoccidioidomycosis.

Mycopathologia 2019 Feb 17;184(1):193-194. Epub 2019 Jan 17.

Centro São Lucas, School of Dentistry, Porto Velho, RO, Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11046-018-0311-4DOI Listing
February 2019

Natural history of experimental arthritis induced by Paracoccidioides brasiliensis in wistar rats.

Rev Soc Bras Med Trop 2019 Jan 14;52:e20180043. Epub 2019 Jan 14.

Instituto de Pesquisa e Desenvolvimento, Universidade do Vale do Paraíba, São José dos Campos, SP, Brasil.

Introduction: Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis in Latin America. This study aimed to evaluate the natural history of Paracoccidioides brasiliensis-induced experimental arthritis of the knee joints in Wistar rats.

Methods: Rats were randomly allocated to either an absolute control group, or 15-day, 45-day, or 90-day experimental (fungus-inoculated) groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/0037-8682-0043-2018DOI Listing
January 2019
2 Reads

Effects of metaperiodate and urea solutions on the serological diagnosis of human sporotrichosis using an indirect ELISA test.

Braz J Microbiol 2019 Jan 13;50(1):139-145. Epub 2018 Dec 13.

Departamento de Microbiologia e Imunologia, Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Rua Gabriel Monteiro da Silva, 700 - Centro, Alfenas, MG, CEP 37130-001, Brazil.

Sporotrichosis is an infection of the skin caused by traumatic inoculation of the fungus Sporothrix schenckii. Definitive diagnosis relies on direct visualization of the fungus or its isolation on culture medium, although both have low sensitivity. Alternatively, the detection of the antibody response offers a more rapid alternative for diagnosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s42770-018-0005-6DOI Listing
January 2019
2 Reads

Photodynamic Antimicrobial Chemotherapy (PACT), using Toluidine blue (TBO) inhibits both growth and dimorphism in Paracoccidioides brasiliensis by a mechanism involving reactive oxygen species (ROS) production.

Photodiagnosis Photodyn Ther 2019 Mar 3;25:421-424. Epub 2019 Jan 3.

Instituto de Pesquisa e Desenvolvimento - IP&D, Universidade do Vale do Paraíba - UNIVAP, Av. Shishima Hifumi, 2911, São José dos Campos, SP, Brazil. Electronic address:

Background: The thermo-dimorphic fungus Paracoccidioides brasiliensis is the pathogen of Paracoccidioidomycosis, an important public health problem in Latin American with prevalence in Brazil. Photodynamic Antimicrobial Chemotherapy (PACT) is a process that combines a photosensitizer and light, producing reactive oxygen species (ROS) that can promote damages to treated cells.

Methods: In this work was study the effect of PACT, using Toluidine blue (TBO) on both yeast and mycelial cells of P. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15721000183037
Publisher Site
http://dx.doi.org/10.1016/j.pdpdt.2019.01.003DOI Listing
March 2019
3 Reads

Paracoccidioides spp. in Soil from the Pampa Biome in Southern Brazil.

Curr Microbiol 2019 Feb 2;76(2):258-262. Epub 2019 Jan 2.

Post-Graduation Program in Health Science, Federal University of Rio Grande (FURG), Rio Grande, Brazil.

High rates of paracoccidioidomycosis disease and infection have been recently reported in southern Brazil. However, the knowledgment about the ecoepidemiology of Paracoccidioides spp. in the region is limited, therefore, this study aimed to evaluate the presence of Paracoccidioides spp. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00284-018-1621-yDOI Listing
February 2019
1 Read

Biliary Paracoccidioidomycosis: An Unusual Infection Simulating Malignant Neoplasm.

Ann Hepatol 2018 Dec;18(1):258-262

Hepatobiliary Surgery, Bonsucesso Federal Hospital, Health Ministry, Rio de Janeiro, Brazil.

Paracoccidioidomycosis is a systemic granulomatous disease caused by the dimorphic fungus Paracoccidioides brasiliensis and is restricted to Latin America. It normally affects lungs, skin and lymph nodes. Abdominal organs are usually not involved. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5604/01.3001.0012.7935DOI Listing
December 2018
3 Reads

Paracoccidioidomycosis in Immunocompromised Patients: A Literature Review.

J Fungi (Basel) 2018 12 26;5(1). Epub 2018 Dec 26.

Department of Medicine, Division of Infectious Diseases, Escola Paulista de Medicina, Universidade Federal de São Paulo, CEP 04039-032 São Paulo, Brazil.

(PCM) is an endemic mycosis found in Latin America that causes systemic disease mostly in immunocompetent hosts. A small percentage of PCM occurs in immunocompromised patients where low clinical suspicion of the infection, late diagnosis, and uncertainties about its management are factors that negatively impact their outcomes. We conducted a literature review searching reports on PCM associated to HIV, cancer, maligned hemopathies, solid organ transplantation, and immunotherapies, in order to check for peculiarities in terms of natural history and challenges in the clinical management of PCM in this population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jof5010002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463037PMC
December 2018
1 Read

Quantitation of pulmonary fungal burden in Paracoccidioides brasiliensis-infected mice by real-time PCR.

Rev Inst Med Trop Sao Paulo 2018 Dec 20;61:e2. Epub 2018 Dec 20.

Universidade de São Paulo, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Departamento de Biologia, Ribeirão Preto, São Paulo, Brazil.

Although colony-forming unit (CFU) counting is widely used to quantify fungal load in tissue from animal experimentally infected with Paracoccidioides brasiliensis, several technical disadvantages have been described. Here we developed highly accurate quantitative PCR (qPCR) assays to determine the relative P brasiliensis load in lungs from infected mice. SYBR Green- and TaqMan-based assays using primers and probe for the 43-kDa glycoprotein (gp43) gene detected as little as 270 gene copies (about 2 fg of DNA) per reaction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/S1678-9946201961002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300791PMC
December 2018
2 Reads

Repurposing approach identifies new treatment options for invasive fungal disease.

Bioorg Chem 2019 Mar 19;84:87-97. Epub 2018 Nov 19.

LORIA, Lorraine University, Nancy, France.

Drug repositioning is the process of discovery, validation and marketing of previously approved drugs for new indications. Our aim was drug repositioning, using ligand-based and structure-based computational methods, of compounds that are similar to two hit compounds previously selected by our group that show promising antifungal activity. Through the ligand-based method, 100 compounds from each of three databases (MDDR, DrugBank and TargetMol) were selected by the Tanimoto coefficient, as similar to LMM5 or LMM11. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bioorg.2018.11.019DOI Listing
March 2019
15 Reads

Paracoccidioidomycosis manifested by sarcoidosis-like cutaneous lesions and caused by Paracoccidioides brasiliensis sensu stricto (S1a).

An Bras Dermatol 2018 Nov/Dec;93(6):902-904

Laboratory of Medical Mycology, Departamento de Microbiologia e Imunologia, Instituto de Biociências de Botucatu, Universidade Estadual Paulista, Botucatu (SP), Brazil.

Molecular studies have shown more than one species of the genus Paracoccidioides to be the causal agent of paracoccidioidomycosis. Efforts have been made to correlate the identified species with epidemiological and clinical data of patients, aiming to determine the real meaning and impact of new species. Bearing this objective in mind, the authors report a clinical case of paracoccidioidomycosis, from São Paulo state, Brazil, that manifested as uncommon sarcoid-like cutaneous lesions and was caused by Paracoccidioides brasiliensis sensu stricto (S1a). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/abd1806-4841.20188293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256202PMC
February 2019
14 Reads

Paracoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine model.

Med Mycol 2018 Nov 24. Epub 2018 Nov 24.

Universidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Campus Araraquara, Departamento de Análises Clínicas, Laboratório de Micologia Clinica, Araraquara, São Paulo, Brasil.

The Paracoccidioides brasiliensis strain downregulated the expression of adhesin Pb14-3-3 (Pb14-3-3 aRNA) was evaluated in a murine model of paracoccidioidomycosis (PCM). Pb14-3-3 aRNA displays attenuated virulence and triggered the formation of fewer granulomas by lowering the fungal burden in the lungs. Additionally, the Pb14-3-3 aRNA showed more elongated yeast cells and less ability to induce pneumocytes apoptosis in vitro. Read More

View Article

Download full-text PDF

Source
http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
Publisher Site
http://dx.doi.org/10.1093/mmy/myy112DOI Listing
November 2018
15 Reads
2.335 Impact Factor

Differentiation of mucosal lesions in mucocutaneous leishmaniasis and paracoccidioidomycosis.

PLoS One 2018 26;13(11):e0208208. Epub 2018 Nov 26.

Department of Social Medicine, Health Sciences Center, Federal University of Espírito Santo, Vitória, Espírito Santo State, Brazil.

Mucocutaneous leishmaniasis and paracoccidioidomycosis are infectious diseases with similar epidemiological and clinical aspects. Cases of both diseases may manifest similar lesions in the mucosa. Therefore, the determination of distinguishing characteristics for the purpose of differential diagnosis is critical for better management of the diseases. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208208PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258372PMC
November 2018
2 Reads

Schinus molle essential oil as a potential source of bioactive compounds: antifungal and antibacterial properties.

J Appl Microbiol 2019 Feb 26;126(2):516-522. Epub 2018 Dec 26.

Department of Microbiology and Immunology - Institute of Biosciences, UNESP - São Paulo State University, Botucatu, São Paulo, Brazil.

Aims: The study was focused on the evaluation of antimicrobial activity in vitro of the essential oil (EO) of leaves from Schinus molle against bacteria and fungi of clinical importance in the search for the discovery of new active compounds.

Methods And Results: The chemical composition of the S. molle EO was determined by gas chromatography/mass spectrometry and its antimicrobial effect was verified by broth microdilution method. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/jam.14157
Publisher Site
http://dx.doi.org/10.1111/jam.14157DOI Listing
February 2019
4 Reads

Insulin Modulates -Induced Inflammation by Restoring the Populations of NK Cells, Dendritic Cells, and B Lymphocytes in Lungs.

J Diabetes Res 2018 22;2018:6209694. Epub 2018 Oct 22.

Laboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences of University Sao Paulo (FCF/USP), São Paulo, Brazil.

Paracoccidioidomycosis, a key issue for Brazilian health service, can be aggravated in patients with impaired immunological responses, such as diabetic patients. We evaluated the role of insulin in inflammatory parameters in diabetic and nondiabetic mice using a systemic mycosis (Pb) model. Diabetic C57BL-6 mice and controls were infected with Pb18 and treated with insulin for 12 days prior to experiments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2018/6209694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217756PMC
March 2019
13 Reads

Paracoccidioidomycosis: characterization of subpopulations of macrophages and cytokines in human mucosal lesions.

Med Mycol 2018 Nov 9. Epub 2018 Nov 9.

Universidade de São Paulo, Faculdade de Medicina, Departamento de Patologia, São Paulo, SP, Brazil.

Mucosal lesions of paracoccidioidomycosis (PCM) are frequently described and clinically important. Macrophages are classified as M1 or M2. M1 are proinflammatory and M2 are related to chronicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/mmy/myy120DOI Listing
November 2018

Depletion of regulatory T cells in ongoing paracoccidioidomycosis rescues protective Th1/Th17 immunity and prevents fatal disease outcome.

Sci Rep 2018 Nov 8;8(1):16544. Epub 2018 Nov 8.

Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brazil.

In human paracoccidioidomycosis (PCM), a primary fungal infection typically diagnosed when the disease is already established, regulatory T cells (Treg) cells are associated with disease severity. Experimental studies in pulmonary PCM confirmed the detrimental role of these cells, but in most studies, Tregs were depleted prior to or early during infection. These facts led us to study the effects of Treg cell depletion using a model of ongoing PCM. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41598-018-35037-8
Publisher Site
http://dx.doi.org/10.1038/s41598-018-35037-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224548PMC
November 2018
18 Reads

Therapy of Non-Dermatophytic Mycoses in Animals.

Authors:
Daniel Elad

J Fungi (Basel) 2018 Oct 30;4(4). Epub 2018 Oct 30.

Department of Clinical Bacteriology and Mycology, The Kimron Veterinary Institute, P.O. Box 12, Bet Dagan 50250, Israel.

This review focuses on aspects of antimycotic therapy specific to veterinary medicine. In the first part, drug availability, limited mostly by economic consideration but also by clinical applicability and specific adverse effects, is described for polyenes, 5 fluorocytosine, azoles, echinocandins and terbinafine. In the second part, current knowledge and experience in the treatment of selected fungal infections are overviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jof4040120DOI Listing
October 2018
3 Reads

Tomographic assessment of thoracic fungal diseases: a pattern and signs approach.

Radiol Bras 2018 Sep-Oct;51(5):313-321

Department of Radiology, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.

Pulmonary fungal infections, which can be opportunistic or endemic, lead to considerable morbidity and mortality. Such infections have multiple clinical presentations and imaging patterns, overlapping with those of various other diseases, complicating the diagnostic approach. Given the immensity of Brazil, knowledge of the epidemiological context of pulmonary fungal infections in the various regions of the country is paramount when considering their differential diagnoses. Read More

View Article

Download full-text PDF

Source
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
Publisher Site
http://dx.doi.org/10.1590/0100-3984.2017.0223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198837PMC
October 2018
22 Reads

DC-SIGN and VDR polymorphisms are associated with chronic form of paracoccidioidomycosis with oral manifestations.

Mycoses 2019 Feb 19;62(2):186-192. Epub 2018 Nov 19.

Departamento de Microbiologia e Imunologia, Universidade Federal de Alfenas, Alfenas, MG, Brazil.

Paracoccidioidomycosis (PCM) is a granulomatous disease caused by fungi of the species complex of the Paracoccidioides genus. One of the main clinical manifestations of PCM is the presence of oral lesions with the presence of epithelioid granulomas. In this work, we aimed to evaluate the frequency of SNPs in the TNF-α, JAK1, VDR, DC-SIGN and FcγRIIa genes in patients with chronic PCM and verify possible association of these SNPs with the organisation pattern of the granulomas in the oral lesions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.12866DOI Listing
February 2019
3 Reads

Ceruloplasmin, transferrin and apolipoprotein A-II play important role in treatment's follow-up of paracoccidioidomycosis patients.

PLoS One 2018 25;13(10):e0206051. Epub 2018 Oct 25.

Universidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu, Botucatu, São Paulo-Brazil.

Paracoccidioidomycosis (PCM) is a systemic disease caused by thermodymorphic fungi of the Paracoccidioides brasiliensis complex, (Paracoccidioides spp.). Patients with PCM reveal specific cellular immune impairment. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206051PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201901PMC
April 2019
14 Reads

Promising New Antifungal Treatment Targeting Chorismate Synthase from .

Antimicrob Agents Chemother 2019 Jan 21;63(1). Epub 2018 Dec 21.

Department of Clinical Analysis and Biomedicine, Universidade Estadual de Maringá, Maringá, Paraná, Brazil

Paracoccidioidomycosis (PCM), caused by , is a systemic mycosis with granulomatous character and a restricted therapeutic arsenal. The aim of this work was to search for new alternatives to treat largely neglected tropical mycosis, such as PCM. In this context, the enzymes of the shikimate pathway constitute excellent drug targets for conferring selective toxicity because this pathway is absent in humans but essential for the fungus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.01097-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325199PMC
January 2019
15 Reads

Computer-aided identification of novel anti-paracoccidioidomycosis compounds.

Future Microbiol 2018 10 12;13:1523-1535. Epub 2018 Oct 12.

Laboratory of Molecular Biology, Universidade Federal de Goiás, Goiânia, Goiás, 74690-900, Brazil.

Aim: The shape-based virtual screening was used for the identification of new compounds anti-paracoccidioidomycosis (PCM).

Materials & Methods: The study was performed according to the following steps: collection and curation of a dataset of quinolinyl N-oxide chalcones with anti-PCM activity, development and validation of shape-based models, application of the best model for virtual screening, and experimental validation.

Results & Conclusion: Among 31 computational hits, eight compounds showed potent antifungal activity and low cytotoxicity for mammalian cells. Read More

View Article

Download full-text PDF

Source
https://www.futuremedicine.com/doi/10.2217/fmb-2018-0175
Publisher Site
http://dx.doi.org/10.2217/fmb-2018-0175DOI Listing
October 2018
4 Reads

Infection by Histoplasma capsulatum, Cryptococcus spp. and Paracoccidioides brasiliensis in bats collected in urban areas.

Transbound Emerg Dis 2018 Dec 16;65(6):1797-1805. Epub 2018 Sep 16.

Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Science, UNESP Univ Estadual Paulista, Botucatu, Brazil.

Epidemiological studies on endemic mycosis can be improved using molecular biology techniques to elucidate the role of bats as reservoirs and vectors of pathogenic fungi for infection of other animals and humans. The objective of this study was to explore the presence of Histoplasma capsulatum, Cryptococcus spp. and Paracoccidioides brasiliensis in insectivorous, frugivorous and nectarivorous bats collected in urban areas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/tbed.12955DOI Listing
December 2018
1 Read

Paracoccidioides spp. and Histoplasma capsulatum: Current and New Perspectives for Diagnosis and Treatment.

Curr Top Med Chem 2018 ;18(15):1333-1348

Department of Microbiology, Immunology and Parasitology, Federal University of Sao Paulo, Sao Paulo, SP, Brazil.

The thermally-dimorphic systemic fungal group includes several important human pathogens: Blastomyces dermatitides, Coccidioides immitis and C. posadasii, Histoplasma capsulatum, Paracoccidioides brasiliensis, P. lutzii, and Talaromyces (Penicillium) marneffei. Read More

View Article

Download full-text PDF

Source
http://www.eurekaselect.com/165829/article
Publisher Site
http://dx.doi.org/10.2174/1568026618666181002112231DOI Listing
February 2019
4 Reads

Secreted aspartyl proteinase (PbSap) contributes to the virulence of Paracoccidioides brasiliensis infection.

PLoS Negl Trop Dis 2018 09 27;12(9):e0006806. Epub 2018 Sep 27.

Department of Microbiology, Immunology and Parasitology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Paracoccidioidomycosis (PCM) is the most prevalent deep mycosis in Latin America and is caused by fungi from the Paracoccidioides genus. Virulence factors are important fungal characteristics that support the development of disease. Aspartyl proteases (Saps) are virulence factors in many human fungal pathogens that play an important role in the host invasion process. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0006806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177206PMC
September 2018
5 Reads

[Clinical and epidemiological characteristics of patients with paracoccidioidomycosis diagnosed in a hospital of Resistencia, Chaco].

Rev Argent Microbiol 2018 Sep 19. Epub 2018 Sep 19.

Hospital Dr. Julio C. Perrando, Resistencia, Chaco, Argentina.

In order to describe the clinical and epidemiological characteristics of paracoccidioidomycosis, a descriptive study of all the cases diagnosed by the Clinical Microbiology Service at Dr. Julio C. Perrando hospital in the city of Resistencia (Chaco Province, Argentina) was conducted. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ram.2018.06.001DOI Listing
September 2018
4 Reads

Immunohistochemical Cross-Reactivity Between Paracoccidioides sp. from Dolphins and Histoplasma capsulatum.

Mycopathologia 2018 Oct 30;183(5):793-803. Epub 2018 Aug 30.

Ryukyu Animal Medical Center, Yone 5-27, Tomigusuku, Okinawa, 901-0224, Japan.

Paracoccidioidomycosis ceti is a cutaneous disease of cetaceans caused by uncultivated Paracoccidioides brasiliensis or Paracoccidioides spp. Serological cross-reactions between paracoccidioidomycosis ceti and paracoccidioidomycosis, paracoccidioidomycosis and histoplasmosis, and paracoccidioidomycosis and coccidioidomycosis have been reported before. The present study aimed to detect immunohistochemical cross-reaction between antibodies to Paracoccidioides sp. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11046-018-0295-0DOI Listing
October 2018
3 Reads

Serological proteomic biomarkers to identify Paracoccidioides species and risk of relapse.

PLoS One 2018 29;13(8):e0202804. Epub 2018 Aug 29.

Universidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu, Botucatu, São Paulo, Brazil.

The sensitivity of the double agar gel immunodiffusion test is about 90% in patients with untreated paracoccidioidomycosis (PCM), but it is much lower in cases of relapse. In addition, serum from patients with PCM caused by Paracoccidioides lutzii, frequent in the Midwest region of Brazil, do not react with the classical antigen obtained from Pb B-339. These findings showed the need for alternative diagnostic methods, such as biological markers through proteomics. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202804PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114792PMC
February 2019
4 Reads

Argentilactone Molecular Targets in Paracoccidioides brasiliensis Identified by Chemoproteomics.

Antimicrob Agents Chemother 2018 Nov 24;62(11). Epub 2018 Oct 24.

Laboratório de Biologia Molecular, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Goiás, Brazil

Paracoccidioidomycosis (PCM) is the cause of many deaths from systemic mycoses. The etiological agents of PCM belong to the genus, which is restricted to Latin America. The infection is acquired through the inhalation of conidia that primarily lodge in the lungs and may disseminate to other organs and tissues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.00737-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201122PMC
November 2018
21 Reads

Chemoproteomic identification of molecular targets of antifungal prototypes, thiosemicarbazide and a camphene derivative of thiosemicarbazide, in Paracoccidioides brasiliensis.

PLoS One 2018 27;13(8):e0201948. Epub 2018 Aug 27.

Laboratório de Biologia Molecular, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.

Paracoccidioidomycosis (PCM) is a neglected human systemic disease caused by species of the genus Paracoccidioides. The disease attacks the host's lungs and may disseminate to many other organs. Treatment involves amphotericin B, sulfadiazine, trimethoprim-sulfamethoxazole, itraconazole, ketoconazole, or fluconazole. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0201948PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110461PMC
February 2019
16 Reads

Acute paracoccidioidomycosis with duodenal and cutaneous involvement and obstructive jaundice.

Med Mycol Case Rep 2018 Jun 12;20:21-25. Epub 2018 Jan 12.

AIDS Division, Carlos Tortelly Municipal Hospital, Ministry of Health, Niterói 24070-090, Rio de Janeiro, Brazil.

Paracoccidioidomycosis (PCM) is the most widespread endemic mycosis in LatinAmerica. If PCM is not diagnosed and treated early and adequately, the endemic fungal infection could result in serious sequelae. We report a case of PCM with duodenal and cutaneous involvement simulating cholangitis that was initially misdiagnosed as a lymphoproliferative disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mmcr.2018.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105911PMC
June 2018
12 Reads

Autophagy in Paracoccidioides brasiliensis under normal mycelia to yeast transition and under selective nutrient deprivation.

PLoS One 2018 23;13(8):e0202529. Epub 2018 Aug 23.

Laboratório de Biologia Celular e Molecular de Fungos, Instituto de Pesquisa e Desenvolvimento, Universidade do Vale do Paraíba, São José dos Campos, SP, Brazil.

Paracoccidioides spp. is a thermally dimorphic fungus endemic to Latin America and the etiological agent of paracoccidioidomycosis (PCM), a granulomatous disease acquired through fungal propagule inhalation by its mammalian host. The infection is established after successful mycelia to yeast transition in the host pulmonary alveoli. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202529PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107164PMC
February 2019
3 Reads

[Brazilian guidelines for the clinical management of paracoccidioidomycosis].

Epidemiol Serv Saude 2018 08 16;27(spe):e0500001. Epub 2018 Aug 16.

Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto, SP, Brasil.

Paracoccidioidomycosis is a systemic fungal disease associated with agricultural activities. Its incidence and prevalence are underestimated because of the lack of reporting in several Brazilian states. If paracoccidiodomycosis is not diagnosed and treated early and adequately, endemic fungal infection may result in serious sequelae. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5123/S1679-49742018000500001DOI Listing
August 2018
26 Reads

Epidemiological aspects of travel-related systemic endemic mycoses: a GeoSentinel analysis, 1997-2017.

J Travel Med 2018 08;25(1)

Department of Global Health, Boston University School of Public Health, Boston, MA, USA.

Background: International travel has increased in the past few decades, placing more travellers at risk of acquiring systemic endemic mycoses. There are limited published data on systemic endemic mycoses among international travellers. We report epidemiological characteristics of non-migrant, international travellers who acquired systemic endemic mycoses during travel. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/jtm/article/doi/10.1093/jtm/tay055/
Publisher Site
http://dx.doi.org/10.1093/jtm/tay055DOI Listing
August 2018
19 Reads

Regulatory T cells in paracoccidioidomycosis.

Virulence 2018 Aug 1:1-12. Epub 2018 Aug 1.

a Department of Immunology , Institute of Biomedical Sciences, University of São Paulo (USP) , São Paulo , Brazil.

This review addresses the role of regulatory T cells (Tregs), which are essential for maintaining peripheral tolerance and controlling pathogen immunity, in the host response against Paracoccidioides brasiliensis, a primary fungal pathogen. A brief introduction on the general features of Treg cells summarizes their main functions, subpopulations, mechanisms of suppression and plasticity. The main aspects of immunity in the diverse forms of the P. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/21505594.2018.1
Publisher Site
http://dx.doi.org/10.1080/21505594.2018.1483674DOI Listing
August 2018
23 Reads

Effects of cytochalasin E on Paracoccidioides brasiliensis.

J Appl Microbiol 2018 Nov 19;125(5):1296-1307. Epub 2018 Sep 19.

Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Aims: To determine the effects of cytochalasin E, isolated from the extremophile fungus Aspergillus felis, on the cells of Paracoccidioides brasiliensis Pb18.

Methods And Results: Cytochalasin E showed a minimal inhibitory concentration of 3·6 μmol l and minimum fungicidal concentration of 7·2 μmol l on P. brasiliensis by in vitro microdilution and IC >964·0 μmol l on murine macrophages. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jam.14053DOI Listing
November 2018
23 Reads

A physiology-based approach to a patient with hyperkalemic renal tubular acidosis.

J Bras Nefrol 2018 Oct-Dec;40(4):410-417. Epub 2018 Jul 23.

Universidade Federal do Espírito Santo, Departamento de Clínica Médica, Divisão de Nefrologia, Vitória, ES, Brasil.

Hyperkalemic renal tubular acidosis is a non-anion gap metabolic acidosis that invariably indicates an abnormality in potassium, ammonium, and hydrogen ion secretion. In clinical practice, it is usually attributed to real or apparent hypoaldosteronism caused by diseases or drug toxicity. We describe a 54-year-old liver transplant patient that was admitted with flaccid muscle weakness associated with plasma potassium level of 9. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/2175-8239-JBN-3821DOI Listing
July 2018
8 Reads

Systemic paracoccidioidomycosis involving breast.

Breast J 2018 09 22;24(5):831-832. Epub 2018 Jul 22.

Department of Radiology, "Antonio Pedro" University Hospital, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/tbj.13078DOI Listing
September 2018
3 Reads