665,643 results match your criteria South African Journal of Surgery Suid-Afrikaanse tydskrif vir chirurgie [Journal]


Microbial Intervention as a Novel Target in Treatment of Non-Alcoholic Fatty Liver Disease Progression.

Cell Physiol Biochem 2018 Dec 6;51(5):2123-2135. Epub 2018 Dec 6.

Department of Gastroenterology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, the Second Affiliated Hospital of South China University of Technology, Guangzhou,

Background/aims: Emerging evidence suggests a close link between gut microbiota and non-alcoholic fatty liver disease (NAFLD). In this study, we aimed to investigate the association between gut microbiota and the DNA methylation of adiponectin (an adipocyte-specific adipocytokine) in rats, following diet-induced NAFLD.

Methods: 50 male SD rats were randomly divided into five groups with or without a high fat diet (HFD), antibiotics, and probiotics, in order to establish an imbalanced gut microbiota and probiotic treatment model in NAFLD rats. Read More

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December 2018
2 Reads

The appropriateness of coronary investigation in myocardial injury and type 2 myocardial infarction (ACT-2): A randomized trial design.

Am Heart J 2018 Oct 25;208:11-20. Epub 2018 Oct 25.

Department of Cardiology, Flinders Medical Centre, Adelaide, Australia; College of Medicine and Public Health, Flinders University of South Australia, Adelaide, Australia. Electronic address:

Background: Elevated troponin level findings among patients presenting with suspected acute coronary syndrome (ACS) or another intercurrent illness undeniably identifies patients at increased risk of mortality. Whilst enhancing our capacity to discriminate risk, the use of high-sensitivity troponin assays frequently identifies patients with myocardial injury (i.e. Read More

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October 2018
2 Reads

Submuscular gluteal abcess: An unusual presentation of rare sacral tuberculosis.

Int J Surg Case Rep 2018 Nov 24;54:55-59. Epub 2018 Nov 24.

Department of Orthopaedic and Traumatology, Cipto Mangunkusumo General Hospital - Faculty of Medicine Universitas, Jl. Pangeran Diponegoro No. 71, Salemba, Central Jakarta, 10430, Indonesia. Electronic address:

Introduction: Both gluteal abscess and sacral tuberculosis are rare entities in spinal tuberculosis cases. Even in endemic country, this atypical presentation may be the cause of delayed diagnosis and treatment.

Presentation Of Case: A 51-year-old woman was admitted with painless massive lump on both of her thighs that have been enlarging for the past 6 months. Read More

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November 2018
3 Reads

Tobacco and cannabis co-use and interrelatedness among adults.

Addict Behav 2018 Nov 27;90:354-361. Epub 2018 Nov 27.

Medical University of South Carolina, Department of Psychiatry and Behavioral Sciences, Charleston, SC, USA.

Cannabis and tobacco co-use is prevalent, but consensus regarding the reasons for co-use among adults and the degree of interrelatedness between these substances is lacking. Reasons for co-use have been explored with younger users, but little data exists for more experienced users with entrenched patterns of co-use. The goal of this study was to examine characteristics and patterns of cannabis-tobacco co-use among adults in the Southeastern United States (US), where there is a legal landscape of generally restrictive cannabis legislation coupled with more permissive tobacco control compared to other US regions. Read More

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November 2018
1 Read

Synergistic Activity of Paclitaxel, Sorafenib, and Radiation Therapy in advanced Renal Cell Carcinoma and Breast Cancer.

Transl Oncol 2018 Dec 3;12(2):381-388. Epub 2018 Dec 3.

Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 120-752, South Korea; Department of Surgery, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of Korea. Electronic address:

Advanced cancer has been shown to be associated with a higher percentage of epigenetic changes than with genetic mutations. Preclinical models have shown that the combination of paclitaxel, sorafenib, and radiation therapy (RT) plays a crucial role in renal cell carcinoma (RCC) and breast cancer. This study aimed to investigate the involvement of mitochondrial cytochrome c-dependent apoptosis in the mechanism of action of a combination of paclitaxel, sorafenib, and RT in RCC and breast cancer. Read More

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December 2018
1 Read

An environmental flow determination method for integrating multiple-scale ecohydrological and complex ecosystem processes in estuaries.

Sci Total Environ 2018 Nov 22;656:482-494. Epub 2018 Nov 22.

Nelson Mandela University, PO Box 77000, Port Elizabeth 6031, South Africa. Electronic address:

This paper presents an environmental flow methodology that was developed to accommodate shallow, highly dynamic micro-tidal estuaries found along the wave-dominated coast of South Arica. This method differs to most other approaches that primarily focus on larger permanently open systems having unrestricted inlets. Following an adaptive, design science research approach, the 7-step method adopted both ecohydrological and ecosystem-based concepts, encapsulating key hydrologicalhydrodynamic-biogeochemical processes, as well as biotic responses. Read More

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November 2018
2 Reads

TroCCL4, a CC chemokine of Trachinotus ovatus, is involved in the antimicrobial immune response.

Fish Shellfish Immunol 2018 Dec 3. Epub 2018 Dec 3.

State Key Laboratory of Marine Resource Utilization in South China Sea, Hainan University, PR China.

CC chemokines are a large subfamily of chemokines that play an important role in the innate immune system. To date, several CC chemokines have been identified in fish species; however, the activities and functions of these putative chemokines remain ambiguous in teleosts, especially in the golden pompano, Trachinotus ovatus. Here, we characterized CC chemokine ligand 4 from T. Read More

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December 2018
2 Reads

Daily energy expenditure of males following alternative reproductive tactics: Solitary roamers spend more energy than group-living males.

Physiol Behav 2018 Dec 3. Epub 2018 Dec 3.

School of Animal, Plant & Environmental Sciences, University of the Witwatersrand, Private Bag 3, WITS, 2050 Johannesburg, South Africa; IPHC, UNISTRA, CNRS, 23 rue du Loess, 67200 Strasbourg, France.

In many species, males follow alternative reproductive tactics (ARTs), where one tactic (called bourgeois) has much higher reproductive success than alternative tactics followed by males with lower competitive ability. The extent to which ARTs differ in energetic costs is unknown, but it is important to understand the fitness payoffs of ARTs. We studied male African striped mice (Rhabdomys pumilio) which follow one of three ARTs: heavy bourgeois males defend harems of females and have 10 times higher reproductive success than smaller roamers, which have ten times higher reproductive success than philopatric males, which remain in their natal group and are the smallest males. Read More

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December 2018
1 Read

Violence and aggression in young women: The importance of psychopathy and neurobiological function.

Physiol Behav 2018 Dec 3. Epub 2018 Dec 3.

Institute for Drug and Alcohol Studies, Departments of Psychiatry, Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, United States.

Psychopathy is one of the most researched risk factors for violence. Yet, research in women is sparse. The present study aimed to test if the link between the four-facet structure of psychopathy and interpersonal violence and aggression was moderated by neurobiological function (indexed by resting respiratory sinus arrhythmia; RSA). Read More

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December 2018

Optimal control applied to a temperature dependent schistosomiasis model.

Biosystems 2018 Dec 3. Epub 2018 Dec 3.

School of Life Sciences, College of Agriculture, Engineering and Science, Westville Campus, University of KwaZulu-Natal, Durban, South Africa.

Schistosomiasis, the most common water-borne infection worldwide, continues to pose a serious public health challenge in developing nations and to travellers who visit these endemic regions. We apply optimal control on a temperature dependent schistosomiasis model. Our optimal control aims to minimize the pre-patent and patent human population at minimal costs. Read More

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December 2018
1 Read

A new automated device for quantifying mechanical nociceptive responses.

J Neurosci Methods 2018 Dec 3. Epub 2018 Dec 3.

Department of Anesthesiology, Perioperative Care and Pain Medicine, New York University School of Medicine, New York, NY, USA; Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY, USA. Electronic address:

Background: Traditional methods to assess pain in rodents depend on measures of nociceptive responses, most commonly from the hind paws. While these measures can quantify nociceptive responses to allow pharmacologic testing, they typically have high inter-experimenter variability and are not time-sensitive enough to correct with neural processes that occur on millisecond scales.

New Method: We have invented a pain detection device that uses changes in skin conductance to measure nocifensive withdrawal responses. Read More

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December 2018
4 Reads

Racial Disparities in Incidence of Young-onset Colorectal Cancer and Patient Survival.

Gastroenterology 2018 Dec 3. Epub 2018 Dec 3.

Department of Epidemiology and Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Background & Aims: Increasing rates of young-onset colorectal cancer (CRC) have attracted substantial research and media attention, but we know little about racial disparities among younger adults with CRC. We examined racial disparities in young-onset CRC by comparing CRC incidence and relative survival among younger (age <50 years) adults, in 2 time periods.

Methods: Using data from the Surveillance, Epidemiology, and End Results program of cancer registries, we estimated CRC incidence rates (per 100,000 persons ages 20 - 54 years) from 1992 through 2014, for different time periods (1992-1996 vs 2010-2014) and races (white vs black). Read More

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December 2018
4 Reads

A risk-scoring model for the prediction of delayed bleeding after colorectal endoscopic submucosal dissection.

Gastrointest Endosc 2018 Dec 3. Epub 2018 Dec 3.

Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. Electronic address:

Background And Aims: Delayed bleeding is an important adverse event after colorectal endoscopic submucosal dissection (ESD). We aimed to investigate the incidence and risk factors of delayed bleeding after colorectal ESD, and to develop a risk scoring model for predicting delayed bleeding.

Methods: This retrospective multicenter study was performed at 5 centers. Read More

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December 2018
1 Read

Intensive versus standard multifactorial cardiovascular risk factor control in screen-detected type 2 diabetes: 5 year and longer-term modelled outcomes of the ADDITION-Leicester study.

Diabetes Metab Res Rev 2018 Dec 6:e3111. Epub 2018 Dec 6.

Leicester Diabetes Centre, University of Leicester, Leicester, UK.

Aims: Diabetes treatment algorithms recommend intensive intervention in those with a shorter duration of disease. Screening provides opportunities for earlier multifactorial cardiovascular risk factor control. Using data from the ADDITION-Leicester study (NCT00318032), we estimated the effects of this approach on modelled risk of diabetes related complications in screen-detected patients. Read More

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December 2018
1 Read

Acupuncture and related interventions for the treatment of symptoms associated with carpal tunnel syndrome.

Cochrane Database Syst Rev 2018 Dec 2;12:CD011215. Epub 2018 Dec 2.

School of Korean Medicine, Pusan National University, Beom-eu, Meulgeum, Yangsan, Korea, South, 626-870.

Background: Carpal tunnel syndrome (CTS) is a compressive neuropathic disorder at the level of the wrist. Acupuncture and other methods that stimulate acupuncture points, such as electroacupuncture, auricular acupuncture, laser acupuncture, moxibustion, and acupressure, are used in treating CTS. Acupuncture has been recommended as a potentially useful treatment for CTS, but its effectiveness remains uncertain. Read More

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December 2018
3 Reads

Early experience of transoral thyroidectomy: Comparison of robotic and endoscopic procedures.

Head Neck 2018 Dec 6. Epub 2018 Dec 6.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Background: The aim of this study was to evaluate the feasibility, safety, and early surgical outcomes of transoral thyroidectomy and to compare robotic and endoscopic procedures.

Methods: A total of 37 patients underwent robotic (23 cases) or endoscopic (14 cases) transoral thyroidectomy. We compared the outcomes of the two procedures. Read More

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December 2018
3 Reads

Rapid and substantial increases in anticoagulant use and expenditure in Australia following the introduction of new types of oral anticoagulants.

PLoS One 2018 6;13(12):e0208824. Epub 2018 Dec 6.

National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australia.

Objectives: To quantify changes in anticoagulant use in Australia since the introduction of Non-vitamin K antagonist anticoagulants (NOACs) and to estimate government expenditure.

Design: Interrupted-time-series analysis quantifying anticoagulant dispensing, before and after first Pharmaceutical Benefits Scheme (PBS) NOAC listing in August 2009 for venous thromboembolism prevention; and expanded listing for stroke prevention in non-valvular atrial fibrillation (AF) in August 2013, up to June 2016. Estimated government expenditure on PBS-listed anticoagulants. Read More

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December 2018

The genetic diversity and relationships of cauliflower (Brassica oleracea var. botrytis) inbred lines assessed by using SSR markers.

PLoS One 2018 6;13(12):e0208551. Epub 2018 Dec 6.

Key Laboratory of Ministry of Education for Genetics, Breeding and Multiple Utilization of Crops, College of Crop Science, Fujian Agriculture and Forestry University, Fuzhou, P.R. China.

Inbred lines are important germplasm in cauliflower breeding programs. To understand the genetic diversity and relationships of cauliflower inbred lines, the use of simple sequence repeat (SSR) markers will be of great value for parental line selection and breeding strategy design. In this study, the genetic diversity and relationships of 165 cauliflower inbred lines primarily derived from southeast China were assessed using SSR markers. Read More

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December 2018

Identifying missed clinical opportunities for the earlier diagnosis of HIV in Australia, a retrospective cohort data linkage study.

PLoS One 2018 6;13(12):e0208323. Epub 2018 Dec 6.

Infectious Diseases, Prince of Wales Hospital, Sydney, NSW, Australia.

Background: Treatment as prevention approaches for HIV require optimal HIV testing strategies to reduce undiagnosed HIV infections. In most settings, HIV testing strategies still result in unacceptably high rates of missed and late diagnoses. This study aimed to identify clinical opportunities for targeted HIV testing in persons at risk to facilitate earlier HIV diagnosis in New South Wales, Australia; and to assess the duration between the diagnosis of specific conditions and HIV diagnosis. Read More

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December 2018

E4orf1: A protein for enhancing glucose uptake despite impaired proximal insulin signaling.

PLoS One 2018 6;13(12):e0208427. Epub 2018 Dec 6.

Department of Nutritional Sciences, Texas Tech University, Lubbock, Texas, United States of America.

Background: Type 2 diabetes is often linked with impaired proximal insulin signaling. Hence, a therapeutic agent that enhances cellular glucose uptake without requiring proximal insulin signaling would be desirable for improving glycemic control. The E4orf1 peptide (E4) derived from human adenovirus 36 (Ad36) promotes cellular glucose uptake in vitro and in vivo, independent of insulin. Read More

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December 2018
2 Reads

A comparison of maternal and newborn health services costs in Sindh Pakistan.

PLoS One 2018 6;13(12):e0208299. Epub 2018 Dec 6.

Division of Women & Child Health, Aga Khan University, Karachi, Pakistan.

Pakistani women suffer the highest rate of maternal mortality in South Asia. A lack of comprehensive knowledge about maternal and newborn health (MNH) services costs impedes policy decisions to maximize the benefit from existing, as well as emerging, MNH interventions in Pakistan. We compared MNH service costs at different levels of care. Read More

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December 2018
2 Reads

Performance of GPS units for deployment on semiaquatic animals.

PLoS One 2018 6;13(12):e0207938. Epub 2018 Dec 6.

Faculty of Technology, Natural Sciences, and Maritime Sciences, Department of Natural Sciences and Environmental Health, University of South-Eastern Norway, Bø i Telemark, Norway.

Global Positioning System (GPS) technology is widely used in wildlife research to study animal movement and habitat use. In order to evaluate the quality and reliability of GPS data, the factors influencing the performance of these devices must be known, especially for semiaquatic species, because terrestrial and aquatic habitat might affect GPS performance differently. We evaluated the location error and fix success rate of three GPS receiver models in stationary tests and on a semi-aquatic mammal, the Eurasian beaver (Castor fiber). Read More

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December 2018

Pseudomonas coronafaciens sp. nov., a new phytobacterial species diverse from Pseudomonas syringae.

PLoS One 2018 6;13(12):e0208271. Epub 2018 Dec 6.

Department of Plant Pathology, Physiology and Weed Science, Tidewater Agricultural Research and Extension Center, Virginia Tech, Suffolk, VA, United States of America.

We propose Pseudomonas coronafaciens sp. nov. as a new species in genus Pseudomonas, which is diverse from P. Read More

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December 2018
1 Read

Atypical and severe manifestations of chikungunya virus infection in French Guiana: A hospital-based study.

PLoS One 2018 6;13(12):e0207406. Epub 2018 Dec 6.

Tropical and Infectious Diseases Department, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana.

Background: French Guiana (FG) was the first country in South America to declare chikungunya virus infection (CHIKV). The outbreak affected about 16,000 persons between February 2014 and October 2015, with several atypical cases, but only two fatal cases. We aimed to describe the clinical presentation of patients hospitalized for CHIKV infection, to estimate and identify risk factors of unusual and severe forms in adult patients. Read More

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December 2018

Cluster randomized trial of comprehensive gender-based violence programming delivered through the HIV/AIDS program platform in Mbeya Region, Tanzania: Tathmini GBV study.

PLoS One 2018 6;13(12):e0206074. Epub 2018 Dec 6.

United States Agency for International Development, Washington, DC, United States of America.

The Tathmini GBV study was a cluster randomized trial to assess the impact of a comprehensive health facility- and community-based program delivered through the HIV/AIDS program platform on reduction in gender-based violence and improved care for survivors. Twelve health facilities and surrounding communities in the Mbeya Region of Tanzania were randomly assigned to intervention or control arms. Population-level effects were measured through two cross-sectional household surveys of women ages 15-49, at baseline (n = 1,299) and at 28 months following program scale-out (n = 1,250). Read More

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December 2018
1 Read

Reinvestigating the status of malaria parasite (Plasmodium sp.) in Indian non-human primates.

PLoS Negl Trop Dis 2018 Dec 6;12(12):e0006801. Epub 2018 Dec 6.

TE-11, Centre for Ecological Sciences, Indian Institute of Sciences, Bangalore, India.

Many human parasites and pathogens have closely related counterparts among non-human primates. For example, non-human primates harbour several species of malaria causing parasites of the genus Plasmodium. Studies suggest that for a better understanding of the origin and evolution of human malaria parasites it is important to know the diversity and evolutionary relationships of these parasites in non-human primates. Read More

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December 2018

Carols by glow sticks: a retrospective analysis of Poisons Information Centre data.

Med J Aust 2018 Dec;209(11):505-508

University of Sydney, Sydney, NSW.

Objective: To win a Christmas hamper. We also devised a study of our most festive seasonal poisoning, to demonstrate how hard we are working while everyone else is partying.

Design: Retrospective analysis of the New South Wales Poisons Information Centre database, which we searched for exposures to the substance code "Cyalume light sticks/glow toys" from 1 July 2013 to 30 June 2017. Read More

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December 2018
1 Read

The emergence and characteristics of the Australian Mamil.

Med J Aust 2018 Dec;209(11):490-494

University of Sydney, Sydney, NSW.

Background: The Mamil (middle-aged man in Lycra) appears to be an emergent cycling-focused species.

Objectives: To explore the nature and distribution of the Mamilian species; to determine whether rates of cycling by middle-aged men in Australia have changed since the pre-Mamilian era.

Setting: Secondary analysis of representative population-based datasets. Read More

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December 2018
1 Read

The MJA-Lancet Countdown on health and climate change: Australian policy inaction threatens lives.

Med J Aust 2018 Dec;209(11):474

School of Public Health, University of Sydney, Sydney, NSW.

Climate plays an important role in human health and it is well established that climate change can have very significant impacts in this regard. In partnership with The Lancet and the MJA, we present the inaugural Australian Countdown assessment of progress on climate change and health. This comprehensive assessment examines 41 indicators across five broad sections: climate change impacts, exposures and vulnerability; adaptation, planning and resilience for health; mitigation actions and health co-benefits; economics and finance; and public and political engagement. Read More

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December 2018
1 Read

Reflex response to airway occlusion in human inspiratory muscles when recruited for breathing and posture.

J Appl Physiol (1985) 2018 Dec 6. Epub 2018 Dec 6.

Neuroscience Research Australia and The University of New South Wales, Sydney, Australia.

Briefly occluding the airway during inspiration produces a short-latency reflex inhibition in human inspiratory muscles. This occlusion reflex seems specific to respiratory muscles; however, it is not known whether the reflex inhibition has a uniform effect across a motoneurone pool when a muscle is recruited concurrently for breathing and posture. In this study, participants were seated and breathed through a mouthpiece that occluded inspiratory airflow for 250 ms at a volume threshold of 0. Read More

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December 2018
2 Reads

Global Development of Anticancer Therapies for Rare Cancers, Pediatric Cancers, and Molecular Subtypes of Common Cancers.

J Glob Oncol 2018 Dec(4):1-11

H. Kim Lyerly, Duke University, Durham, NC; Jun Ren, Capital University Medical Center; Zhimin Yang, China Food and Drug Administration, Beijing, People's Republic of China; Gi Hyun Kim, Korea Ministry of Food and Drug Safety, Seoul, South Korea; Sumimasa Nagai, University of Tokyo; Sumimasa Nagai, Tomohiro Yamaguchi, and Ken Hatogai, Pharmaceuticals and Medical Devices Agency; Hiroshi Katayama, National Cancer Center Hospital, Tokyo, Japan; Silvy Da Rocha Dias, European Medicines Agency, London, United Kingdom; Daniel McManus and Kathy Soltys, Health Canada, Ottawa, Ontario, Canada; Olufumilayo Olopade, University of Chicago, Chicago, IL; Nancy Goodman, Kids V Cancer, Washington, DC; Greg Reaman, US Food and Drug Administration; Thomas Gross, US National Cancer Institute, Bethesda, MD, and Renzo Canetta, Independent Consultant.

Advances in genetic sequencing and other diagnostic technologies have enabled the use of precision medicine in clinical cancer care, as well as the development of novel therapies that are targeted to specific molecular drivers of cancer. Developing these new agents and making them accessible to patients requires global clinical studies and regulatory review and approval by different national regulatory agencies. Whereas these global trials present challenges for drug developers who conduct them and regulatory agencies who oversee them, they also raise practical issues about patients with low-frequency cancers who need these therapies. Read More

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December 2018
1 Read

Asymmetric Synthesis of Chiral Flavan-3-Ols.

Nat Prod Res 2018 Dec 6:1-16. Epub 2018 Dec 6.

a Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China , Hengyang , Hunan , PR China.

Flavan-3-ols are a series of natural products widely present in plants and show versatile biological activities. The structures of such compounds are characterized by owing two adjacent chiral centers and three rings. Their interesting structures and promising biological activities have driven increasing research developments toward the preparation of enantioenriched flavan-3-ols. Read More

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December 2018
1 Read

Infection control in the community.

Authors:
Ray Higginson

Br J Community Nurs 2018 Dec;23(12):590-595

Senior Lecturer in Critical Care Physiology, University of South Wales.

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December 2018

Roles of CD133 in microvesicle formation and oncoprotein trafficking in colon cancer.

FASEB J 2018 Dec 6:fj201802018R. Epub 2018 Dec 6.

Division of Life Sciences, Korea University, Seoul, South Korea.

Extracellular vesicles contain various cellular components that are involved in tumor growth, metastasis, and immune escape. Extracellular vesicles are classified into 2 groups, namely, exosomes and microvesicles (MV). Although the formation and roles of exosomes have been studied, the exact functions of MVs and mechanisms underlying MV release are not fully understood. Read More

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December 2018
2 Reads

Hatching success and survival of fish early life stages in a chronic exposure to nevirapine: a case study of the Mozambique tilapia.

Int J Environ Health Res 2018 Dec 6:1-16. Epub 2018 Dec 6.

a Department of Zoology , University of Johannesburg , Johannesburg , South Africa.

The anti-retroviral nevirapine has been detected in surface waters throughout South Africa and its effects on non-target aquatic animals are still unknown. The aim was to investigate the potential effects of nevirapine on the hatching success and survival of Oreochromis mossambicus early life stages through a chronic exposure. The exposer started with newly fertilized O. Read More

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December 2018
1 Read

Improving the Electrochemical Properties of the Manganese-Based P3 Phase by Multiphasic Intergrowth.

Inorg Chem 2018 Dec 6. Epub 2018 Dec 6.

State Key Laboratory of Powder Metallurgy , Central South University , Changsha , Hunan 410083 , P. R. China.

Layered transition-metal oxides are one kind of the most promising cathode materials for sodium-ion batteries. In this study, we propose a strategy to enhance the electrochemical properties of P3-type manganese-based layered oxide cathode by introducing a small amount of layered P2 and Li-O'3 phases. Powder X-ray diffraction (PXRD) structural refinement and aberration-corrected scanning transmission electron microscopy (STEM) are performed to confirm the microstructures of different samples. Read More

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December 2018

Tolerance and efficacy of BRAF plus MEK inhibition in patients with melanoma who previously have received programmed cell death protein 1-based therapy.

Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

Background: Combined BRAF and MEK inhibition (BRAF-MEK) is a standard therapy for patients with BRAF V600-mutant melanoma, but to the authors' knowledge, the tolerance, adverse event (AE) profile, and efficacy have not been well defined in the post-programmed cell death protein 1 (PD-1) setting.

Methods: Patients with BRAF V600-mutant melanoma who received combined BRAF-MEK after prior PD-1-based therapy were assembled from 4 tertiary care centers in the United States and Australia. Dose modification was defined as a treatment break, dose reduction, or intermittent dosing. Read More

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December 2018

Early surveillance is associated with less incidence and severity of breast cancer-related lymphedema compared with a traditional referral model of care.

Cancer 2018 Dec 6. Epub 2018 Dec 6.

Australian Lymphoedema Education, Research and Treatment (ALERT) Program, Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia.

Background: Bioimpedance spectroscopy (BIS) has enabled the early identification of breast cancer-related lymphedema. In this study, differences in health service metrics and in the incidence of breast cancer-related lymphedema are evaluated in an early surveillance model of care compared with a traditional referral model of care.

Methods: In a retrospective analysis of data from 753 women who underwent BIS measures between January 1, 2007 and December 31, 2016, 188 women were assigned to the "early surveillance" group if they began lymphedema monitoring presurgery (n = 121) or within 90 days postsurgery (n = 67), and 285 women were assigned to the "traditional referral" group if they began monitoring after 90 days postsurgery. Read More

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December 2018
1 Read

Universal screening for Lynch Syndrome in a large consecutive cohort of Chinese colorectal cancer patients: high prevalence and unique molecular features.

Int J Cancer 2018 Dec 6. Epub 2018 Dec 6.

Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.

The prevalence of Lynch syndrome (LS) varies significantly in different populations, suggesting that ethnic features might play an important role. We enrolled 3330 consecutive Chinese patients who had surgical resection for newly diagnosed colorectal cancer. Universal screening for LS was implemented, including immunohistochemistry for mismatch repair (MMR) proteins, BRAF mutation test and germline sequencing. Read More

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December 2018
2 Reads
5.085 Impact Factor

Erratum. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome.

Hum Reprod 2018 Dec 6. Epub 2018 Dec 6.

National Health and Medical Research Council Centre for Research Excellence in PCOS, Monash University, Melbourne, Victoria, Australia.

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December 2018
1 Read

BaiHui: Cross-species Brain-specific Network Built with Hundreds of Hand-curated Datasets.

Bioinformatics 2018 Dec 5. Epub 2018 Dec 5.

Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States.

Motivation: Functional gene networks, representing how likely two genes work in the same biological process, are important models for studying gene interactions in complex tissues. However, a limitation of the current network-building scheme is the lack of leveraging evidence from multiple model organisms as well as the lack of expert curation and quality control of the input genomic data.

Results: Here, we present BaiHui, a brain-specific functional gene network built by probabilistically integrating expertly-hand-curated (by reading original publications) heterogeneous and multi-species genomic data in human, mouse and rat brains. Read More

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December 2018
4 Reads

Reply to Ambrosioni et al.

Clin Infect Dis 2018 Dec 6. Epub 2018 Dec 6.

Veterans Affairs San Diego Healthcare System and University of California San Diego, San Diego, California.

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December 2018
1 Read

Protein-protein interaction sites prediction by ensemble random forests with synthetic minority oversampling technique.

Bioinformatics 2018 Dec 5. Epub 2018 Dec 5.

Bioinformatics and Mathematical Biosciences Lab, Department of Agronomy, Horticulture and Plant Science, South Dakota State University, Brookings, SD, USA.

Motivation: The prediction of protein-protein interaction (PPI) sites is a key to mutation design, catalytic reaction, and the reconstruction of PPI networks. It is a challenging task considering the significant abundant sequences and the imbalance issue in samples.

Results: A new ensemble learning based method, EL-SMURF, was proposed for PPI sites prediction in this study. Read More

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December 2018
1 Read

Impact of HLA allele-KIR pairs on HIV clinical outcome in South Africa.

J Infect Dis 2018 Dec 6. Epub 2018 Dec 6.

Department of Paediatrics, University of Oxford, Oxford, United Kingdom.

Background: HLA class I contributes to HIV immune control through antigen presentation to both cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. However, by contrast with investigations of CTL, studies of NK cells in HIV control through HLA-killer immunoglobulin-like receptor (KIR) interactions remain sparse in African cohorts.

Methods: 312 treatment naïve, chronically HIV-infected adults were recruited from South Africa, and the effects of HLA-KIR pairs on clinical outcome were statistically analyzed. Read More

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December 2018
1 Read

Trastuzumab Therapy for 9 Weeks vs 1 Year for Human Epidermal Growth Factor 2-Positive Breast Cancer-Reply.

JAMA Oncol 2018 Dec 6. Epub 2018 Dec 6.

Department of Oncology, Helsinki University Hospital, Helsinki University, Helsinki, Finland.

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December 2018
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