58 results match your criteria Somogyi Phenomenon

New strategies of diagnostic and therapeutic approach to emergencies in the evolution of patients with diabetes mellitus (Review).

Exp Ther Med 2022 Feb 28;23(2):178. Epub 2021 Dec 28.

Department of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.

Diabetes mellitus, known as the most widespread disease in the world, along with four other chronic diseases, involves major expenditures and significant human resources for care, thus representing a burden on any type of health care system especially due to its rapid evolution of acute and chronic complications. For the emergency department (ED), the requirements of patients with acute complications of diabetes, determine expenses which are three times higher than those for non-diabetic patients and their hospitalizations are four times more frequent. The acute complications for which patients with diabetes most frequently require the ED are hypoglycemic, hyperosmolar, or ketoacidosis coma as well as alterations of the general condition that is typical of hypoglycemia, diabetic ketoacidosis (DKA), hyperglycemic hyperosmolar state and new-onset hyperglycemia. Read More

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February 2022

Suspecting unwitnessed hypoglycaemia.

Pract Neurol 2021 Apr 13. Epub 2021 Apr 13.

Department of Neurology and Stroke Medicine, St George's Hospital Atkinson Morley Regional Neuroscience Centre, London, Greater London, UK.

Hypoglycaemic coma can present with acute neurological dysfunction mimicking stroke. It may be masked by normoglycaemia due to physiological compensatory mechanisms (Somogyi phenomenon). Specific MR brain scan changes should alert the clinician to consider this alternative to stroke in the acute setting in patients with a history of recurrent hypoglycaemia, even when the blood glucose is not low at presentation. Read More

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Photomorphogenesis in the Picocyanobacterium Includes Increased Phycobilisome Abundance Under Blue Light, Phycobilisome Decoupling Under Near Far-Red Light, and Wavelength-Specific Photoprotective Strategies.

Front Plant Sci 2021 18;12:612302. Epub 2021 Mar 18.

Balaton Limnological Institute, Centre for Ecological Research, Tihany, Hungary.

Photomorphogenesis is a process by which photosynthetic organisms perceive external light parameters, including light quality (color), and adjust cellular metabolism, growth rates and other parameters, in order to survive in a changing light environment. In this study we comprehensively explored the light color acclimation of , a common cyanobacterium in turbid freshwater shallow lakes, using nine different monochromatic growth lights covering the whole visible spectrum from 435 to 687 nm. According to incident light wavelength, cells performed great plasticity in terms of pigment composition, antenna size, and photosystem stoichiometry, to optimize their photosynthetic performance and to redox poise their intersystem electron transport chain. Read More

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[Pre-programmed genes].

János Szabad

Orv Hetil 2017 Aug;158(34):1323-1330

Orvosi Biológiai Intézet, Szegedi Tudományegyetem, Általános Orvostudományi Kar Szeged, Somogyi u. 4., 6720.

Cells feel good and carry on perfect functions when they contain the right types of proteins in the right concentration, at the right time and sites. There are mechanisms that ensure the right level of gene expression in the different cell types: the formation of protein molecules based on the DNA-encoded genetic information. Gene expression can also be regulated through the compactness of chromatin, i. Read More

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Rebound hyperglycaemia in diabetic cats.

J Feline Med Surg 2016 08 4;18(8):587-96. Epub 2015 Jun 4.

School of Veterinary Science, The University of Queensland, Queensland, Australia

Objectives: Rebound hyperglycaemia (also termed Somogyi effect) is defined as hyperglycaemia caused by the release of counter-regulatory hormones in response to insulin-induced hypoglycaemia, and is widely believed to be common in diabetic cats. However, studies in human diabetic patients over the past quarter century have rejected the common occurrence of this phenomenon. Therefore, we evaluated the occurrence and prevalence of rebound hyperglycaemia in diabetic cats. Read More

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Pituitary adenylate cyclase activating polypeptide (PACAP) signalling exerts chondrogenesis promoting and protecting effects: implication of calcineurin as a downstream target.

PLoS One 2014 18;9(3):e91541. Epub 2014 Mar 18.

Department of Anatomy, Histology and Embryology, University of Debrecen, Faculty of Medicine, Debrecen, Hungary.

Pituitary adenylate cyclase activating polypeptide (PACAP) is an important neurotrophic factor influencing differentiation of neuronal elements and exerting protecting role during traumatic injuries or inflammatory processes of the central nervous system. Although increasing evidence is available on its presence and protecting function in various peripheral tissues, little is known about the role of PACAP in formation of skeletal components. To this end, we aimed to map elements of PACAP signalling in developing cartilage under physiological conditions and during oxidative stress. Read More

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December 2014

Mechanical loading stimulates chondrogenesis via the PKA/CREB-Sox9 and PP2A pathways in chicken micromass cultures.

Cell Signal 2014 Mar 12;26(3):468-82. Epub 2013 Dec 12.

Department of Anatomy, Histology and Embryology, University of Debrecen, Medical and Health Science Centre, Nagyerdei krt. 98, H-4032 Debrecen, Hungary. Electronic address:

Biomechanical stimuli play important roles in the formation of articular cartilage during early foetal life, and optimal mechanical load is a crucial regulatory factor of adult chondrocyte metabolism and function. In this study, we undertook to analyse mechanotransduction pathways during in vitro chondrogenesis. Chondroprogenitor cells isolated from limb buds of 4-day-old chicken embryos were cultivated as high density cell cultures for 6 days. Read More

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Progressive retinal degeneration and glial activation in the CLN6 (nclf) mouse model of neuronal ceroid lipofuscinosis: a beneficial effect of DHA and curcumin supplementation.

PLoS One 2013 4;8(10):e75963. Epub 2013 Oct 4.

Institute of Human Genetics, University of Regensburg, Regensburg, Germany ; Department of Ophthalmology, University of Cologne, Cologne, Germany.

Neuronal ceroid lipofuscinosis (NCL) is a group of neurodegenerative lysosomal storage disorders characterized by vision loss, mental and motor deficits, and spontaneous seizures. Neuropathological analyses of autopsy material from NCL patients and animal models revealed brain atrophy closely associated with glial activity. Earlier reports also noticed loss of retinal cells and reactive gliosis in some forms of NCL. Read More

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[Morning hyperglycemia in children and adolescents with type 1 diabetes and different modes of therapy: an evaluation of the DPV data pool].

Klin Padiatr 2012 Nov 22;224(7):471-5. Epub 2012 Aug 22.

Klinik für Kinder- und Jugendmedizin, St. Vincenz-Krankenhaus, Paderborn.

Early morning hyperglycemia is frequent among children and adolescents with type 1 diabetes. Reasons are a dawn phenomenon, a Somogyi phenomenon or a lack of insulin in the morning hours. Only few studies are published regarding incidence and relation to different modes of basal insulin treatment in this population. Read More

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November 2012

The dawn phenomenon and the Somogyi effect - two phenomena of morning hyperglycaemia.

Endokrynol Pol 2011 ;62(3):276-84

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

Morning hyperglycaemia in diabetic subjects may be caused by the dawn phenomenon, or the Somogyi effect, or poor glycaemic control. The dawn phenomenon occurs when endogenous insulin secretion decreases or when the effect of the exogenous insulin administered to the patient the day before disappears, together with a physiological increase in insulin-antagonistic hormones. The Somogyi effect is present in the case of excessive amounts of exogenous insulin. Read More

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Adoptive transfer of peripheral immune cells potentiates allodynia in a graded chronic constriction injury model of neuropathic pain.

Brain Behav Immun 2011 Mar 4;25(3):503-13. Epub 2010 Dec 4.

Discipline of Pharmacology, School of Medical Sciences, University of Adelaide, Adelaide 5005, Australia.

Recent evidence demonstrates that peripheral immune cells contribute to the nociceptive hypersensitivity associated with neuropathic pain by infiltrating the central nervous system (CNS). We have recently developed a rat model of graded chronic constriction injury (CCI) by varying the exposure of the sciatic nerve and control non-nerve tissue to surgical placement of chromic gut. We demonstrate that splenocytes can contribute significantly to CCI-induced allodynia, as adoptive transfer of these cells from high pain donors to low pain recipients potentiates allodynia (P<0. Read More

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[Elevated serum dipeptidyl peptidase-4 activity in type 1 diabetes mellitus: a direct comparison].

Orv Hetil 2010 May;151(22):899-902

Semmelweis Egyetem, Altalános Orvostudományi Kar II. Belgyógyászati Klinika Budapest Szentkirályi utca 46. 1088.

Unlabelled: Dipeptidyl peptidase-4 (DPP-4) has an important role in the carbohydrate metabolism with the degradation of incretin hormones.

Aim: We assessed the serum DPP-4 activity both in fasting and postprandial condition in patients with type 1-, type 2 diabetes and healthy controls.

Methods: Serum DPP-4 activities were determined at fasting sate and at 60 and 180 minutes after test meal. Read More

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Sessile hemocytes as a hematopoietic compartment in Drosophila melanogaster.

Proc Natl Acad Sci U S A 2009 Mar 4;106(12):4805-9. Epub 2009 Mar 4.

Institute of Genetics, Biological Research Center of the Hungarian Academy of Sciences, PO Box 521, H-6701, Szeged, Hungary.

The blood cells, or hemocytes, in Drosophila participate in the immune response through the production of antimicrobial peptides, the phagocytosis of bacteria, and the encapsulation of larger foreign particles such as parasitic eggs; these immune reactions are mediated by phylogenetically conserved mechanisms. The encapsulation reaction is analogous to the formation of granuloma in vertebrates, and is mediated by large specialized cells, the lamellocytes. The origin of the lamellocytes has not been formally established, although it has been suggested that they are derived from the lymph gland, which is generally considered to be the main hematopoietic organ in the Drosophila larva. Read More

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Different reactivities of amphetamines with N-methyl-bis(trifluoroacetamide) in heated gas chromatographic injectors.

Pharmazie 2008 Mar;63(3):233-4

National Institute of Forensic Toxicology, Budapest, Hungary.

A fast gas chromatographic mass spectrometric method has been developed earlier for the determination of amphetamine derivatives in human serum and urine. For derivatization, N-methyl-bis(trifluoroacetamide) (MBTFA) was used. Derivatization was performed using an on-line mode, since 1 microl of MBTFA and 1 microl sample extract, dissolved in toluene were injected simultaneously. Read More

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Nocturnal hypoglycaemias in type 1 diabetic patients: what can we learn with continuous glucose monitoring?

Diabetes Metab 2007 Nov 24;33(5):360-5. Epub 2007 Jul 24.

Service of Endocrinology, Diabetology and Metabolism,Centre Hospitalier Universitaire Vaudois, 1011, Lausanne, Switzerland.

Aim: In type 1 diabetic patients (T1DM), nocturnal hypoglycaemias (NH) are a serious complication of T1DM treatment; self-monitoring of blood glucose (SMBG) is recommended to detect them. However, the majority of NH remains undetected on an occasional SMBG done during the night. An alternative strategy is the Continuous glucose monitoring (CGMS), which retrospectively shows the glycaemic profile. Read More

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November 2007

Stereoselective quantification of methadone and a d(6)-labeled isotopomer using high performance liquid chromatography-atmospheric pressure chemical ionization mass-spectrometry: application to a pharmacokinetic study in a methadone maintained subject.

Ther Drug Monit 2006 Aug;28(4):559-67

Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide 5005, Australia.

There is evidence that the apparent oral clearance of rac-methadone is induced during the early phase of methadone maintenance treatment. However, it is not known if this is due to changes in bioavailability or if this phenomenon is stereoselective. This knowledge can be obtained by administering a dose of stable-labeled methadone at selected times during ongoing treatment. Read More

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Fasting hyperglycemia: etiology, diagnosis, and treatment.

John P Sheehan

Diabetes Technol Ther 2004 Aug;6(4):525-33

Case Western Reserve University, Cleveland, Ohio, USA.

Suboptimal glycemic control in individuals with type 1 and type 2 diabetes mellitus is associated with an increased risk of microvascular and macrovascular complications. Even brief periods of hyperglycemia increase the risk of complications. Fasting hyperglycemia is a phenomenon that has been observed in essentially all individuals with diabetes and may be due to dysregulation of the normal circadian hormonal patterns resulting in increased hepatic glucose output. Read More

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[Continuous glucose monitoring system, as a valuable tool in the care of children and adolescents with diabetes mellitus].

Orv Hetil 2004 Jun;145(24):1265-70

Semmelweis Egyetem, Altalános Orvostudományi Kar, I. Gyermekklinika, Budapest.

Introduction: Good metabolic control of diabetic patients is mainly based on the results of self measured blood glucose levels. Important excursions of blood glucose may, however, be hidden in the usual case of 4-5 daily determinations. The aim of this paper was to give detailed information about this new diagnostic tool and to report the first Hungarian pediatric experiences with continuous glucose monitoring. Read More

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[Blood pressure volatility--a new parameter for determining blood pressure variability in type-1 diabetes mellitus].

Orv Hetil 2003 Sep;144(36):1779-84

Semmelweis Egyetem, Altalános Orvostudományi Kar, II. Belgyógyászati Klinika, Budapest.

Introduction: In diabetes the heart rate variability is decreased because of the autonomic neuropathy and parallel with this phenomenon the overnight blood pressure fall is lost. Presumably this change in the hemodynamic parameters is connected with the fact that the cardiovascular complications in type 1 diabetic patients are 2-4 times more frequent than in healthy patients. The volatility, as a new factor, is the dispersion of the proportion of the blood pressure values following each other. Read More

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September 2003

Stable myocardial performance at clamped aorta based solely on the internal mammary artery graft flow: a functional test.

F Tarr A Somogyi

Acta Chir Hung 1994 ;34(1-2):29-42

Haynal Imre Medical University, Department of Cardiovascular Surgery, Budapest, Hungary.

Authors report their experiences with arterial revascularization of the heart using the internal mammary artery (IMA). A method of intraoperative measurement of the free cut end and the effective graft flow of the IMA after meticulous anatomical dissection is described. Free cut end IMA flow was measured both at systemic and extracorporeal pump perfusion pressure and was found as 145+/-26 ml/min and 135+/-16 ml, respectively. Read More

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Nocturnal blood glucose control in type I diabetes mellitus.

Diabetes Care 1993 Dec;16 Suppl 3:71-89

Department of Internal Medicine and Endocrine and Metabolism and Sciences, University of Perugia, Italy.

A major problem in replacing insulin in type I diabetes mellitus is that currently no depot preparation exists that is capable of mimicking the background insulin secretion of the healthy pancreas. Because all of the currently available intermediate- or long-acting insulin preparations have a peaked-action profile, excess insulin action at midnight and insulin waning at dawn occur whenever such an insulin preparation is given at supper time. If the target fasting plasma glucose is the ambitious near-normoglycemia of intensive insulin therapy, intermediate-acting insulin at suppertime easily results in hypoglycemia in the early evening hours and hyperglycemia in the fasting state. Read More

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December 1993

Fasting hyperglycemia in type I diabetes mellitus.

J Am Osteopath Assoc 1993 Jul;93(7):769-74

Division of Endocrinology, Shadyside Hospital, Pittsburgh, PA 15232.

The differential diagnosis of fasting hyperglycemia in type I diabetes includes the Somogyi effect, the dawn phenomenon, and insufficient insulin administration. To determine the causes of fasting hyperglycemia and their effect on subsequent daytime blood glucose control, the authors retrospectively reviewed blood glucose profiles of 126 patients with type I diabetes. The Somogyi effect accounted for 12. Read More

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Evaluation of criteria contributions for the classification of systemic lupus erythematosus.

Scand J Rheumatol 1993 ;22(2):58-62

Department of Physiology, School of Medicine, Zagreb, Croatia.

The American Rheumatism Association (ACR) preliminary and revised criteria for classification of systemic lupus erythematosus (SLE) were evaluated for sensitivity and specificity in a population of 100 patients with SLE and 100 patients with other rheumatic diseases. Bayes' theorem was applied for evaluation of ARA criteria for the classification of SLE and a scoring system was developed which allows simple determination of the probability of SLE. The evaluation revealed considerable differences in values of the ARA criteria. Read More

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[The dawn or Somogyi phenomenon? High morning fasting blood sugar values in young type-1 diabetics].

R W Holl E Heinze

Dtsch Med Wochenschr 1992 Oct;117(40):1503-7

Abteilung Pädiatrie I, Universitäts-Kinderklinik Ulm.

High blood sugar levels in the morning in juvenile type 1 diabetics may be caused by a Somogyi phenomenon (counter-regulation after nocturnal hypoglycaemia) or insulin resistance in the morning hours (dawn phenomenon). To enable differentiation between the two, 1,562 blood sugar profiles (24 h, 3 h, 6 h) were determined in 161 children and juveniles (74 boys, 87 girls; mean age 10.8 [1. Read More

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October 1992

Renal tubular transport of morphine, morphine-6-glucuronide, and morphine-3-glucuronide in the isolated perfused rat kidney.

Drug Metab Dispos 1991 Nov-Dec;19(6):1087-92

Department of Clinical and Experimental Pharmacology, University of Adelaide, Australia.

The isolated perfused rat kidney was used to examine the renal handling of morphine and its inactive metabolite morphine-3-glucuronide (M3G), and active metabolite morphine-6-glucuronide (M6G). The kidneys were perfused with Krebs-Henseleit buffer (pH 7.4) containing albumin, glucose, and amino acids, and drug concentrations were measured by high performance liquid chromatography. Read More

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