38,212 results match your criteria Somatosensory & Motor Research [Journal]


The cellular basis of mechanosensory Merkel-cell innervation during development.

Elife 2019 Feb 22;8. Epub 2019 Feb 22.

Department of Physiology and Cellular Biophysics, Columbia University, New York, United States.

Touch sensation is initiated by mechanosensory neurons that innervate distinct skin structures; however, little is known about how these neurons are patterned during mammalian skin development. We explored the cellular basis of touch-receptor patterning in mouse touch domes, which contain mechanosensory Merkel cell-neurite complexes and abut primary hair follicles. At embryonic stage 16. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7554/eLife.42633DOI Listing
February 2019

Lower limb amputees undergo long-distance plasticity in sensorimotor functional connectivity.

Sci Rep 2019 Feb 21;9(1):2518. Epub 2019 Feb 21.

D'Or Institute for Research and Education (IDOR), Rio de Janeiro, 22281-100, Brazil.

Amputation in adults is associated with an extensive remapping of cortical topography in primary and secondary sensorimotor areas. Here, we used tactile residual limb stimulation and 3T functional magnetic resonance imaging in humans to investigate functional connectivity changes in the sensorimotor network of patients with long-term lower limb traumatic amputations with phantom sensation, but without pain. We found a pronounced reduction of inter-hemispheric functional connectivity between homologous sensorimotor cortical regions in amputees, including the primary (S1) and secondary (S2) somatosensory areas, and primary (M1) and secondary (M2) motor areas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-39696-zDOI Listing
February 2019

Somatosensory Electrical Stimulation Does Not Improve Motor Coordination in Patients with Unilateral Knee Osteoarthritis.

J Clin Med 2019 Feb 19;8(2). Epub 2019 Feb 19.

Human Performance Lab, Schulthess Clinic, 8008 Zurich, Switzerland.

Non-surgical treatment of knee osteoarthritis (KOA) is often focused on the motor component of KOA even though there is evidence that sensory dysfunctions play an important role in the impaired control of the affected joint. Excitation of sensory afferents can increase motor function by exploiting the nervous system's ability to adapt to changing environments (i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcm8020259DOI Listing
February 2019

Beyond binary parcellation of the vestibular cortex - A dataset.

Data Brief 2019 Apr 22;23:103666. Epub 2019 Jan 22.

Department of Neurology, Ludwig-Maximilians Universität, Munich, Germany.

The data-set presented in this data article is supplementary to the original publication, doi:10.1016/j.neuroimage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dib.2019.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369267PMC

Increased cerebral responses to salient transitions between alternating stimuli in chronic migraine with medication overuse headache and during migraine attacks.

Cephalalgia 2019 Feb 20:333102418825359. Epub 2019 Feb 20.

2 Headache Research Unit, Department of Neurology, CHR Citadelle, University of Liège, Liège, Belgium.

Introduction: In a previous study exploring central pain modulation with heterotopic stimuli in healthy volunteers, we found that transitions between sustained noxious and innocuous thermal stimulations on the foot activated the "salience matrix". Knowing that central sensory processing is abnormal in migraine, we searched in the present study for possible abnormalities of these salient transitional responses in different forms of migraine and at different time points of the migraine cycle.

Methods: Participants of both sexes, mostly females, took part in a conditioned pain modulation experiment: Migraineurs between (n = 14) and during attacks (n = 5), chronic migraine patients with medication overuse headache (n = 7) and healthy volunteers (n = 24). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0333102418825359DOI Listing
February 2019

Time-resolved quantification of the dynamic extracellular space in the brain: Study of cortical spreading depression.

J Neurophysiol 2019 Feb 20. Epub 2019 Feb 20.

Multidisciplinary Research Center, Shantou University, China.

Extracellular diffusion in the brain is customarily characterized by two parameters, the extracellular space (ECS) volume fraction α and the diffusion tortuosity λ. How these two parameters are temporarily modified and correlated in a physiological/pathological event remains unclear to date. Using tetramethyl ammonium (TMA) as the ECS ion tracer in a newly updated iontophoretic sinusoidal method, we studied in this work the dynamic α( t) and λ( t) in rat somatosensory cortex during spreading depression (SD). Read More

View Article

Download full-text PDF

Source
https://www.physiology.org/doi/10.1152/jn.00348.2018
Publisher Site
http://dx.doi.org/10.1152/jn.00348.2018DOI Listing
February 2019
1 Read

A Cross-Species Analysis Reveals a General Role for Piezo2 in Mechanosensory Specialization of Trigeminal Ganglia from Tactile Specialist Birds.

Cell Rep 2019 Feb;26(8):1979-1987.e3

Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar St., New Haven, CT 06510, USA. Electronic address:

A major challenge in biology is to link cellular and molecular variations with behavioral phenotypes. Here, we studied somatosensory neurons from a panel of bird species from the family Anatidae, known for their tactile-based foraging behavior. We found that tactile specialists exhibit a proportional expansion of neuronal mechanoreceptors in trigeminal ganglia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.01.100DOI Listing
February 2019

Contemporary Dance Practice Improves Motor Function and Body Representation in Huntington's Disease: A Pilot Study.

J Huntingtons Dis 2019 ;8(1):97-110

Brain and Spine Institute (ICM), Sorbonne Université, Pitié-Salpêtrière University Hospital, Paris, France.

Background: Physical exercise improves neurological conditions, but adherence is hard to establish. Dance might be a promising alternative; however, since patients with Huntington's disease (HD) suffer from rhythmic movement execution deficits, any metric dance practice must be avoided.

Objective: Here we asked, if contemporary dance, a lyrical dance form, practiced for two hours per week over five months, might improve motor function, neuropsychiatric variables, cognition and brain volume of HD patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JHD-180315DOI Listing
January 2019

Do theta oscillations explain the somatosensory change detection mechanism?

Biol Psychol 2019 Feb 13. Epub 2019 Feb 13.

Intelligent Robotics Institute, School of Mechatronical Engineering, Beijing Institute of Technology, Beijing, China; Key Laboratory of Biomimetic Robots and Systems, Ministry of Education, Beijing, China.

Recent research has indicated that the mismatch negativity (MMN) is elicited in response to a discernible small change of a somatosensory stimulus applied on the hand. However, the neural mechanism for detecting small change of somatosensory stimulus remains unknown. In the present study, we developed a novel pressure stimulation device using air jet applied on the index finger pad, and determined the just noticeable differences (JNDs) of pressure discrimination for each subject. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biopsycho.2019.02.001DOI Listing
February 2019
2 Reads
3.403 Impact Factor

Treatment of neurotrophic keratopathy with minimally invasive corneal neurotisation: long-term clinical outcomes and evidence of corneal reinnervation.

Br J Ophthalmol 2019 Feb 15. Epub 2019 Feb 15.

Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

Aim: To report clinical outcomes and evidence of corneal innervation in patients with neurotrophic keratopathy (NK) treated with minimally invasive corneal neurotisation (MICN) using a sural nerve graft and donor sensory nerves from the face.

Methods: Patients undergoing MICN at The Hospital for Sick Children, Toronto, Canada were prospectively recruited. Data on central corneal sensation (CCS, measured with Cochet-Bonnet aesthesiometer), best-corrected visual acuity (BCVA) and corneal epithelial integrity were collected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313042DOI Listing
February 2019

Cortical inhibitory dysfunction in epilepsia partialis continua: A high frequency oscillation somatosensory evoked potential study.

Clin Neurophysiol 2019 Jan 25;130(4):439-444. Epub 2019 Jan 25.

Neurology, Neurophysiology and Neurobiology Unit, Department of Medicine, Università Campus Bio-Medico di Roma, Rome, Italy. Electronic address:

Objective: The pathophysiology of epilepsia partialis continua (EPC) is still unclear, a thalamo-cortical circuit dysfunction has been hypothesized. The aim of present study is the functional evaluation of the thalamo-cortical network in EPC by means of the study of low- and high-frequency somatosensory evoked potentials (LF-SEP and HF-SEP).

Methods: Median LF-SEP and HF-SEP were recorded in 3 patients with EPC and in 2 patients with rolandic lesions without EPC (non-EPC). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clinph.2019.01.005DOI Listing
January 2019

Regional specificity of cortico-thalamic coupling strength and directionality during waxing and waning of spike and wave discharges.

Sci Rep 2019 Feb 14;9(1):2100. Epub 2019 Feb 14.

Institute of Physiology I, Westfälische Wilhelms-Universität Münster, Münster, Germany.

Spike-wave discharges (SWDs) on the EEG during absence epilepsy are waxing and waning stages of corticothalamic hypersynchrony. While the somatosensory cortex contains an epileptic focus, the role of thalamic nuclei in SWD generation is debated. Here we assess the contribution of distinct thalamic nuclei through multiple-site unit recordings in a genetic rat model of absence epilepsy and cross-correlation analysis, revealing coupling strength and directionality of neuronal activity at high temporal resolution. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-37985-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375974PMC
February 2019

The Membrane Proximal Domain of TRPV1 and TRPV2 Channels Mediates Protein⁻Protein Interactions and Lipid Binding In Vitro.

Int J Mol Sci 2019 Feb 5;20(3). Epub 2019 Feb 5.

Biophysics Unit, Department of Biochemistry and Molecular Biology, School of Medicine, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallés, Catalonia, Spain.

Constitutive or regulated membrane protein trafficking is a key cell biology process. Transient receptor potential channels are somatosensory proteins in charge of detecting several physical and chemical stimuli, thus requiring fine vesicular trafficking. The membrane proximal or pre-S1 domain (MPD) is a highly conserved domain in transient receptor potential channels from the vanilloid (TRPV) subfamily. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20030682DOI Listing
February 2019

Volume alterations of brainstem subregions in migraine with aura.

Neuroimage Clin 2019 Feb 4;22:101714. Epub 2019 Feb 4.

Faculty of Medicine, University of Belgrade, Serbia; Center for Headaches, Neurology Clinic, Clinical Center of Serbia, Serbia.

Background: The brainstem plays a significant role in migraine pathogenesis, but a relationship between volume alterations of brainstem subregions and migraine aura characteristics has not been sufficiently investigated. The aim of this study is to compare the volume of the brainstem, and its subregions, between patients with a migraine with aura (MwA) and healthy controls (HC), and also to correlate characteristics of MwA and the volume of the brainstem subregions.

Methods: Forty-two MwA and 42 HCs, balanced by sex and age, were selected for this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nicl.2019.101714DOI Listing
February 2019

Functional and neurochemical disruptions of brain hub topology in chronic pain.

Pain 2019 Jan 16. Epub 2019 Jan 16.

Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI, United States.

A critical component of brain network architecture is a robust hub structure, wherein hub regions facilitate efficient information integration by occupying highly connected and functionally central roles in the network. Across a wide range of neurological disorders, hub brain regions seem to be disrupted, and the character of this disruption can yield insights into the pathophysiology of these disorders. We applied a brain network-based approach to examine hub topology in fibromyalgia, a chronic pain condition with prominent central nervous system involvement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001480DOI Listing
January 2019
2 Reads

Proprioceptive Localization of the Fingers: Coarse, Biased, and Context-Sensitive.

IEEE Trans Haptics 2019 Feb 14. Epub 2019 Feb 14.

The proprioceptive sense provides somatosensory information about positions of parts of the body, information that is essential for guiding behavior and monitoring the body. Few studies have investigated the perceptual localization of individual fingers, despite their importance for tactile exploration and fine manipulation. We present two experiments assessing the performance of proprioceptive localization of multiple fingers, either alone or in combination with visual cues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1109/TOH.2019.2899302DOI Listing
February 2019

Neuropathic Pain in Pediatric Oncology: A Clinical Decision Algorithm.

Paediatr Drugs 2019 Feb 14. Epub 2019 Feb 14.

Division of Anesthesia, Department of Pediatric Medicine, St. Jude Children's Research Hospital, Mail Stop 130, 262 Danny Thomas Place, Memphis, TN, 38105-3678, USA.

Neuropathic pain in pediatric oncology can be caused by distinct lesions or disease processes affecting the somatosensory system, including chemotherapy-related neuronal injury, solid tumor-related involvement of neural structures, post-surgical neuropathic pain-including phantom limb pain and pain after limb-sparing surgery-and the complex circumstances of neuropathic pain at the end of life. Treatment algorithms reflect the general treatment principles applied for adult neuropathic pain, but the dose regimens applied in children are modest and rarely escalated to the maximum doses to optimize analgesic efficacy. Pharmacological management of neuropathic pain should be based on a stepwise intervention strategy, as combinations of medications are the most effective approach. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40272-018-00324-4DOI Listing
February 2019

Functional Network-Based Statistics Reveal Abnormal Resting-State Functional Connectivity in Minimal Hepatic Encephalopathy.

Front Neurol 2019 29;10:33. Epub 2019 Jan 29.

Department of Radiology, Fujian Medical University Union Hospital, Fuzhou, China.

Whole-brain functional network analysis is an emerging methodology for exploring the mechanisms underlying hepatic encephalopathy (HE). This study aimed to identify the brain subnetwork that is significantly altered within the functional connectome in minimal HE (MHE), the earliest stage of HE. The study enrolled 19 cirrhotic patients with MHE and 19 controls who underwent the resting-state functional magnetic resonance imaging and cognitive assessment based on the Psychometric Hepatic Encephalopathy Score (PHES). Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fneur.2019.00033
Publisher Site
http://dx.doi.org/10.3389/fneur.2019.00033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362410PMC
January 2019
3 Reads

Increased Anxiety-Related Behavior, Impaired Cognitive Function and Cellular Alterations in the Brain of Cend1-deficient Mice.

Front Cell Neurosci 2018 29;12:497. Epub 2019 Jan 29.

Laboratory of Cellular and Molecular Neurobiology-Stem Cells, Department of Neurobiology, Hellenic Pasteur Institute, Athens, Greece.

Cend1 is a neuronal-lineage specific modulator involved in coordination of cell cycle exit and differentiation of neuronal precursors. We have previously shown that Cend1 mice show altered cerebellar layering caused by increased proliferation of granule cell precursors, delayed radial granule cell migration and compromised Purkinje cell differentiation, leading to ataxic gait and deficits in motor coordination. To further characterize the effects of Cend1 genetic ablation we determined herein a range of behaviors, including anxiety and exploratory behavior in the elevated plus maze (EPM), associative learning in fear conditioning, and spatial learning and memory in the Morris water maze (MWM). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fncel.2018.00497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361865PMC
January 2019
4.289 Impact Factor

Intraoperative evoked potential monitoring for detecting cerebral injury during adult aneurysm clipping surgery: a systematic review and meta-analysis of diagnostic test accuracy.

BMJ Open 2019 Feb 12;9(2):e022810. Epub 2019 Feb 12.

Department of Anesthesia and Perioperative Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.

Objectives: We aim to evaluate the diagnostic test accuracy (DTA) of intraoperative evoked potential (EP) monitoring to detect cerebral injury during clipping of cerebral aneurysms.

Design: Systematic review.

Data Sources: Major electronic databases including MEDLINE, EMBASE, LILACS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-022810DOI Listing
February 2019

Noninvasive vagus nerve stimulation alters neural response and physiological autonomic tone to noxious thermal challenge.

PLoS One 2019 13;14(2):e0201212. Epub 2019 Feb 13.

VA Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, La Jolla, CA, United States of America.

The mechanisms by which noninvasive vagal nerve stimulation (nVNS) affect central and peripheral neural circuits that subserve pain and autonomic physiology are not clear, and thus remain an area of intense investigation. Effects of nVNS vs sham stimulation on subject responses to five noxious thermal stimuli (applied to left lower extremity), were measured in 30 healthy subjects (n = 15 sham and n = 15 nVNS), with fMRI and physiological galvanic skin response (GSR). With repeated noxious thermal stimuli a group × time analysis showed a significantly (p < . Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0201212PLOS
February 2019

Estimation of the Balance-Keeping Control Law Applied by a Human Being Upon a Sudden Sagittal Tilt Perturbation.

J Biomech Eng 2019 Apr;141(4)

Mechanical Engineering Department, Middle East Technical University, Ankara 06800, Turkey e-mail: .

This study aims to estimate the control law employed by the central nervous system (CNS) to keep a person in balance after a sudden disturbance. For this aim, several experiments were carried out, in which the subjects were perturbed sagittally by using a single-axis tilt-platform and their motions were recorded with appropriate sensors. The analysis of the experimental results leads to the contribution of this paper as a conjecture that the CNS commands the muscular actuators of the joints according to an adaptive proportional-derivative (PD) control law such that its gains and set points are updated continuously. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1115/1.4042683DOI Listing

Decoding neural activity to predict rat locomotion using intracortical and epidural arrays.

J Neural Eng 2019 Feb 12. Epub 2019 Feb 12.

Biomedical Engineering Department, Northwestern University, Chicago, Illinois, UNITED STATES.

Objective: Recovery of voluntary gait after spinal cord injury (SCI) requires the restoration of effective motor cortical commands, either by means of a mechanical connection to the limbs, or by restored functional connections to muscles. The latter approach might use functional electrical stimulation (FES), driven by cortical activity, to restore voluntary movements. Moreover, there is evidence that this peripheral stimulation, synchronized with patients' voluntary effort, can strengthen descending projections and recovery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1741-2552/ab0698DOI Listing
February 2019

Fibromyalgia and the concept of resilience.

Clin Exp Rheumatol 2019 Jan-Feb;37 Suppl 116(1):105-113. Epub 2019 Feb 8.

Clinical and Oncological Psychology, Città della Salute e della Scienza Hospital of Turin, Turin, Italy.

The concept of resilience varies according to the context in which it is used. Resilience is broadly defined as a protective factor that makes people less vulnerable to future adverse life events, in this implying the previous occurrence of an adverse event that has to be confronted before individual equilibrium can be restored. This definition can be applied to fibromyalgia and other chronic pain situations. Read More

View Article

Download full-text PDF

Source
February 2019
6 Reads

Estrus-Cycle Regulation of Cortical Inhibition.

Curr Biol 2019 Feb 7;29(4):605-615.e6. Epub 2019 Feb 7.

Bernstein Center for Computational Neuroscience Berlin, Humboldt-Universität zu Berlin, Philippstraße 13, Haus 6, 10115 Berlin, Germany; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Neuroscience Research Center, NeuroCure Cluster of Excellence, Charitéplatz 1, 10117 Berlin, Germany. Electronic address:

Female mammals experience cyclical changes in sexual receptivity known as the estrus cycle. Little is known about how estrus affects the cortex, although alterations in sensation, cognition and the cyclical occurrence of epilepsy suggest brain-wide processing changes. We performed in vivo juxtacellular and whole-cell recordings in somatosensory cortex of female rats and found that the estrus cycle potently altered cortical inhibition. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cub.2019.01.045DOI Listing
February 2019

Neural Substrates of Drosophila Larval Anemotaxis.

Curr Biol 2019 Feb 7;29(4):554-566.e4. Epub 2019 Feb 7.

Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA; Department of Zoology, Cambridge University, Cambridge, UK. Electronic address:

Animals use sensory information to move toward more favorable conditions. Drosophila larvae can move up or down gradients of odors (chemotax), light (phototax), and temperature (thermotax) by modulating the probability, direction, and size of turns based on sensory input. Whether larvae can anemotax in gradients of mechanosensory cues is unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cub.2019.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380933PMC
February 2019

Initial absence of N20 waveforms from median nerve somatosensory evoked potentials in a patient with cardiac arrest and good outcomes.

Clin Exp Emerg Med 2019 Feb 12. Epub 2019 Feb 12.

Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

A 34-year-old male was brought to the hospital with a chest gunshot wound. Pulseless upon arrival, blood pressure was absent for 10 minutes. A thoracotomy resulted in return of spontaneous circulation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15441/ceem.18.015DOI Listing
February 2019
1 Read

Imbalance between Excitatory and Inhibitory Synaptic Transmission in the Primary Somatosensory Cortex Caused by Persistent Nociception in rats.

J Pain 2019 Feb 8. Epub 2019 Feb 8.

Institute for Biomedical Sciences of Pain and Institute for Functional Brain Disorders, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, PR China. Electronic address:

There is substantial evidence supporting the notion that the primary somatosensory (S1) cortex is an important structure involved in the perceptional component of pain. However, investigations have mainly focused on other pain-related formations, and few reports have been provided to investigate the synaptic plasticity in the S1 cortex in response to persistent pain. In the present study, we report that bee venom (BV) injection triggered an imbalance between excitatory and inhibitory synaptic transmission in the S1 cortex in rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpain.2018.11.014DOI Listing
February 2019

The deep biology of cognition: Moving toward a comprehensive neurodevelopmental model of Turner syndrome.

Am J Med Genet C Semin Med Genet 2019 Feb 11. Epub 2019 Feb 11.

Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Individuals with Turner syndrome (TS) often exhibit specific deficits in visual-spatial functions, arithmetical abilities, social cognition, and executive functions with preserved general intelligence and preserved or enhanced verbal skills. This unique pattern of cognitive strengths and weaknesses is accompanied by a well-described neuroanatomical phenotype characterized by decreased gray matter volumes in premotor, somatosensory, and parietal-occipital cortex, and increased volumes of the amygdala and orbitofrontal cortex. Why the absence of the second sex chromosome should produce these effects remains poorly understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ajmg.c.31679DOI Listing
February 2019

High-order thalamic inputs to primary somatosensory cortex are stronger and longer lasting than cortical inputs.

Elife 2019 Feb 11;8. Epub 2019 Feb 11.

Department of Neuroscience, Columbia University, New York, United States.

Layer (L) 2/3 pyramidal neurons in the primary somatosensory cortex (S1) are sparsely active, spontaneously and during sensory stimulation. Long-range inputs from higher areas may gate L2/3 activity. We investigated their in vivo impact by expressing channelrhodopsin in three main sources of feedback to rat S1: primary motor cortex, secondary somatosensory cortex, and secondary somatosensory thalamic nucleus (the posterior medial nucleus, POm). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7554/eLife.44158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370338PMC
February 2019

Impaired Postural Control and Altered Sensory Organization During Quiet Stance Following Neurotoxic Chemotherapy: A Preliminary Study.

Integr Cancer Ther 2019 Jan-Dec;18:1534735419828823

2 The Ohio State University, Columbus, OH, USA.

Individuals diagnosed with chemotherapy-induced peripheral neuropathy (CIPN) demonstrate impaired balance and carry an increased risk of falling. However, prior investigations of postural instability have only compared these individuals against healthy controls, limiting the understanding of impairments associated with CIPN. Therefore, the purpose of this study was to better isolate postural control impairments that are associated with CIPN. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1534735419828823DOI Listing
February 2019

Neurological Prognostication After Cardiac Arrest in the Era of Target Temperature Management.

Curr Neurol Neurosci Rep 2019 Feb 9;19(2):10. Epub 2019 Feb 9.

Department of Neurology, Mayo Clinic, Rochester, MN, USA.

Purpose Of Review: The purpose of this study is to provide an updated review on neurological prognostication in comatose patients after cardiac arrest in light of current targeted temperature management (TTM) strategies.

Recent Findings: With improved pre-hospital and hospital care, death due to cardiac arrest is decreasing. Yet, most survivors have poor neurological outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11910-019-0922-2DOI Listing
February 2019
1 Read

Haptic perception is altered in children with developmental coordination disorder.

Neuropsychologia 2019 Feb 7;127:29-34. Epub 2019 Feb 7.

Human Sensorimotor Control Laboratory of School of Kinesiology, University of Minnesota, USA.

Developmental coordination disorder (DCD) is a neurodevelopmental disorder affecting the motor system, but it may also present with signs of somatosensory dysfunction. This study examined whether haptic perception, which relies on somatosensory afferents, is impaired in children with DCD. Haptic sensitivity and acuity were systematically quantified in children with DCD and contrasted to the performance of typically developing (TD) children and young adults (each group N = 20). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuropsychologia.2019.02.004DOI Listing
February 2019

Vibrotactile piezoelectric stimulation system with precise and versatile timing control for somatosensory research.

J Neurosci Methods 2019 Feb 7;317:29-36. Epub 2019 Feb 7.

Division of Newborn Medicine, Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

Background: Tactile stimulations systems are useful for studying the somatosensory system in children because they are innocuous and safe. Stimulators based on piezoelectric actuator are useful, but there is still a need for such systems capable of providing accurate and versatile control of timing and pattern of activation.

New Method: We have implemented a vibrotactile stimulating system useful for behavioral and electroencephalography (EEG) and magnetoencephalography (MEG) research. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01650270193004
Publisher Site
http://dx.doi.org/10.1016/j.jneumeth.2019.02.002DOI Listing
February 2019
5 Reads

Cerebral F-FDG metabolism alteration in a neuropathic pain model following brachial plexus avulsion: a PET/CT study in rats.

Brain Res 2019 Feb 6. Epub 2019 Feb 6.

School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Department of Rehabilitation Medicine, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address:

The present study aimed to investigate cerebral metabolic changes in a neuropathic pain model following deafferentation. A total of 24 Sprague-Dawley rats were included for modeling of right brachial plexus avulsion (BPA) through the posterior approach. As nerve injury would cause central sensitization and facilitate pain sensitivity in other parts of the body, thermal withdrawal latency (TWL) of the intact forepaw was assessed to investigate the level of pain perception following BPA-induced neuropathic pain. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00068993193007
Publisher Site
http://dx.doi.org/10.1016/j.brainres.2019.02.005DOI Listing
February 2019
6 Reads

The impact of dihydropyridine derivatives on the cerebral blood flow response to somatosensory stimulation and spreading depolarization.

Br J Pharmacol 2019 Feb 9. Epub 2019 Feb 9.

Department of Medical Physics and Informatics, Faculty of Medicine and Faculty of Science and Informatics, University of Szeged; Koranyi fasor 9, H-6721, Szeged, Hungary.

Background And Purpose: A new class of heat shock protein co-inducer dihydropyridine derivatives devoid of calcium channel antagonist and vasodilator effects have been recently developed with the purpose to target neurodegeneration selectively. Here we set out to evaluate the action of one of these novel compounds LA1011 on neurovascular coupling in the ischemic rat cerebral cortex. As a reference, we applied nimodipine, a well-known calcium channel antagonist, vasodilator dihydropyridine compound. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bph.14611DOI Listing
February 2019
1 Read

Dunn's Model of Sensory Processing: An Investigation of the Axes of the Four-Quadrant Model in Healthy Adults.

Brain Sci 2019 Feb 7;9(2). Epub 2019 Feb 7.

Occupational Therapy Doctoral Program, School of Exercise & Rehabilitation Sciences, College of Health & Human Services, University of Toledo, Toledo, OH 43606, USA.

We examined the behavioral response (BR) and threshold (T) axes of Dunn's four-quadrant model of sensory processing (1997). We assessed whether they are ordinal ranges and if variation is associated with other similarly described characteristics: Introversion/Extraversion (I/E) of Eysenck's personality model (Sato, 2005), and somatosensory event related potentials (SERP) and their gating (Davies & Gavin, 2007). From healthy adults ( = 139), we obtained: Adult/Adolescent Profile (A/ASP, Brown & Dunn, 2002) and Eysenck's Personality Questionnaire, Brief Version (Sato, 2005) scores and peak amplitude and gating factor of SERP P50. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/brainsci9020035DOI Listing
February 2019

Functional Reorganization in the Primary Somatosensory Cortex of Rat Following Hind-Paw Amputation: A Study of Functional Imaging with 1.5 Tesla MRI.

Turk Neurosurg 2019 Jan 24. Epub 2019 Jan 24.

Acibadem Mehmet Ali Aydinlar University, School of Medicine, Department of Neurosurgery, Istanbul, Turkey.

Aim: Trauma and diabetes with concomitant vascular pathologies are leading causes of limb amputations. Functionality following amputation procedures is very important for social re-integration of the patients. In this study, we aimed to learn how rat primary somatosensory cortex (pSSC) responses to the loss of inputs from hind-paw, using fMRI of an inferior magnetic power (1. Read More

View Article

Download full-text PDF

Source
http://www.turkishneurosurgery.org.tr/summary_en_doi.php3?do
Publisher Site
http://dx.doi.org/10.5137/1019-5149.JTN.25595-18.2DOI Listing
January 2019
3 Reads
0.529 Impact Factor

Neuronal correlates of label facilitated tactile perception.

Sci Rep 2019 Feb 7;9(1):1606. Epub 2019 Feb 7.

Brain Language Laboratory, Department of Philosophy and Humanities, WE4, Freie Universität Berlin, 14195, Berlin, Germany.

It is a long-standing question in neurolinguistics, to what extent language can have a causal effect on perception. A recent behavioural study reported that participants improved their discrimination ability of Braille-like tactile stimuli after one week of implicit association training with language stimuli being co-presented redundantly with the tactile stimuli. In that experiment subjects were exposed twice a day for 1 h to the joint presentation of tactile stimuli presented to the fingertip and auditorily presented pseudowords. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-37877-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367477PMC
February 2019

Somatosensory stimulation treatments for postoperative analgesia of mixed hemorrhoids: Protocol for a systematic review and network meta-analysis.

Medicine (Baltimore) 2019 Feb;98(6):e14441

The 3rd Teaching Hospital/Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine.

Background: Pain after hemorrhoidal surgery bothers both clinicians and patients. Somatosensory stimulation treatments have shown promising effect on the pain after hemorrhoidal surgery, but the comparative effectiveness between them has not been studied. We aim to determine the relative effectiveness among these treatments on pain relief after hemorrhoidal surgery by using network meta-analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000014441DOI Listing
February 2019
2 Reads
5.723 Impact Factor

Changes in the Organization of the Secondary Somatosensory Cortex While Processing Lumbar Proprioception and the Relationship With Sensorimotor Control in Low Back Pain.

Clin J Pain 2019 Feb 5. Epub 2019 Feb 5.

KU Leuven Department of Rehabilitation Sciences, Tervuursevest 101, box 1501, 3001 Leuven, Belgium.

Objectives: Patients with non-specific low back pain (NSLBP) rely more on ankle compared to lower back proprioception during standing, perform sit-to-stand-to-sit (STSTS) movements slower, and exhibit perceptual impairments at the lower back. However, no studies investigated whether these sensorimotor impairments relate to a reorganization of the primary and secondary somatosensory cortices (S1 and S2) and primary motor cortex (M1) during proprioceptive processing.

Methods: Proprioceptive stimuli were applied at lower back and ankle muscles during functional magnetic resonance imaging (fMRI) in 15 patients with NSLBP and 13 controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/AJP.0000000000000692DOI Listing
February 2019

Probing the Link Between Perception and Oscillations: Lessons from Transcranial Alternating Current Stimulation.

Neuroscientist 2019 Feb 7:1073858419828646. Epub 2019 Feb 7.

3 Department of Cognitive Neurology, University Medicine Göttingen, Göttingen, Germany.

Brain oscillations are regarded as important for perception as they open and close time windows for neural spiking to enable the effective communication within and across brain regions. In the past, studies on perception primarily relied on the use of electrophysiological techniques for probing a correlative link between brain oscillations and perception. The emergence of noninvasive brain stimulation techniques such as transcranial alternating current stimulation (tACS) provides the possibility to study the causal contribution of specific oscillatory frequencies to perception. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1073858419828646DOI Listing
February 2019

Motor and cognitive performances in pre-lingual cochlear implant adolescents, related with vestibular function and auditory input.

Acta Otolaryngol 2019 Feb 7:1-6. Epub 2019 Feb 7.

a Laboratory of Otoneurology , British Hospital , Montevideo , Uruguay.

Background: Information about the role of auditory input and motor control is limited.

Objectives: Assessment the relationship between auditory and vestibular information with specific motor and cognitive functions.

Methods: Posturography in 17 Pre-lingual Cochlear Implant Adolescents, (PCIA) age 14. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/00016489.2018.1549750DOI Listing
February 2019

Early-life sleep disruption increases parvalbumin in primary somatosensory cortex and impairs social bonding in prairie voles.

Sci Adv 2019 Jan 30;5(1):eaav5188. Epub 2019 Jan 30.

VA Portland Healthcare System, Portland, OR, USA.

Across mammals, juveniles sleep more than adults, with rapid eye movement (REM) sleep at a lifetime maximum early in life. One function of REM sleep may be to facilitate brain development of complex behaviors. Here, we applied 1 week of early-life sleep disruption (ELSD) in prairie voles (), a highly social rodent species that forms lifelong pair bonds. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/sciadv.aav5188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353622PMC
January 2019

The Localization Research of Brain Plasticity Changes after Brachial Plexus Pain: Sensory Regions or Cognitive Regions?

Neural Plast 2019 8;2019:7381609. Epub 2019 Jan 8.

School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Objective: Neuropathic pain after brachial plexus injury remains an increasingly prevalent and intractable disease due to inadequacy of satisfactory treatment strategies. A detailed mapping of cortical regions concerning the brain plasticity was the first step of therapeutic intervention. However, the specific mapping research of brachial plexus pain was limited. Read More

View Article

Download full-text PDF

Source
https://www.hindawi.com/journals/np/2019/7381609/
Publisher Site
http://dx.doi.org/10.1155/2019/7381609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341257PMC
January 2019
2 Reads

Somatosensory system integrity explains differences in treatment response after stroke.

Neurology 2019 Feb 6. Epub 2019 Feb 6.

From the Departments of Anatomy and Neurobiology (M.L.I., D.J.R., S.C.C.), Biomedical Engineering (J.R.R., D.J.R.), Neurology (V.C. , S.C.C.), Mechanical and Aerospace Engineering (D.J.R.), and Physical Medicine and Rehabilitation (D.J.R. , S.C.C.), University of California at Irvine; and Department of Mechanical Engineering (E.T.W.), University of Idaho, Moscow.

Objective: To test the hypothesis that, in the context of robotic therapy designed to enhance proprioceptive feedback via a Hebbian model, integrity of both somatosensory and motor systems would be important in understanding interparticipant differences in treatment-related motor gains.

Methods: In 30 patients with chronic stroke, behavioral performance, neural injury, and neural function were quantified for somatosensory and motor systems. Patients then received a 3-week robot-based therapy targeting finger movements with enhanced proprioceptive feedback. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000007041DOI Listing
February 2019

Brain-State-Dependent Modulation of Neuronal Firing and Membrane Potential Dynamics in the Somatosensory Thalamus during Natural Sleep.

Cell Rep 2019 Feb;26(6):1443-1457.e5

Integrated Physiology of Brain Arousal Systems, Lyon Neuroscience Research Center, INSERM U1028-CNRS UMR5292, Université Claude-Bernard-Lyon 1, 69372 Lyon, France.

The thalamus plays a central role in sleep rhythms in the mammalian brain and, yet, surprisingly little is known about its function and interaction with local cortical oscillations during NREM sleep (NREM). We investigated the neuronal correlates of cortical barrel activity in the two corresponding thalamic nuclei, the ventral posterior medial (VPM), and the posterior medial (Pom) nuclei during natural NREM in mice. Our data reveal (1) distinct modulations of VPM and Pom activity throughout NREM episodes, (2) a thalamic nucleus-specific phase-locking to cortical slow and spindle waves, (3) cell-specific subthreshold spindle oscillations in VPM neurons that only partially overlap with cortical spindles, and (4) that spindle features evolve throughout NREM episodes and vary according to the post-NREM state. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.01.038DOI Listing
February 2019

Mapping Alterations of the Functional Structure of the Cerebral Cortex in Obsessive-Compulsive Disorder.

Cereb Cortex 2019 Feb 4. Epub 2019 Feb 4.

Centro Investigación Biomédica en Red de Salud Mental, CIBERSAM, Barcelona, Spain.

We mapped alterations of the functional structure of the cerebral cortex using a novel imaging approach in a sample of 160 obsessive-compulsive disorder (OCD) patients. Whole-brain functional connectivity maps were generated using multidistance measures of intracortical neural activity coupling defined within isodistant local areas. OCD patients demonstrated neural activity desynchronization within the orbitofrontal cortex and in primary somatosensory, auditory, visual, gustatory, and olfactory areas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cercor/bhz008DOI Listing
February 2019
4 Reads
8.665 Impact Factor

Corticobasal Syndrome: Neuroimaging and Neurophysiological Advances.

Eur J Neurol 2019 Feb 5. Epub 2019 Feb 5.

IRCCS Neuromed Institute, Pozzilli, IS.

Corticobasal degeneration (CBD) is a neurodegenerative condition characterized by 4R-tau protein deposition in several brain regions that clinically manifests itself as a heterogeneous atypical parkinsonism typically expressing in the adulthood. The prototypical clinical phenotype of CBD is corticobasal syndrome (CBS). Important insights into the pathophysiological mechanisms underlying motor and higher cortical symptoms in CBS have been gained by using advanced neuroimaging and neurophysiological techniques. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ene.13928DOI Listing
February 2019