37,974 results match your criteria Somatosensory & Motor Research [Journal]


Multimodal approach for neurologic prognostication of out-of-hospital cardiac arrest patients undergoing targeted temperature management.

Resuscitation 2018 Dec 15. Epub 2018 Dec 15.

Department of Emergency Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

Aim: Since the introduction of targeted temperature management (TTM), the accuracy and timing of prognostic tests for post-cardiac arrest patients have changed. Although previous studies have demonstrated the effectiveness of a multimodal approach in assessing the prognosis of TTM patients, few studies have investigated an optimised strategy that sequentially combines different prognostic modalities. This study identified an optimal sequential combination of prognostic modalities to predict poor neurologic outcomes in patients undergoing TTM. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2018.11.007DOI Listing
December 2018

Embodied Precision: Intranasal Oxytocin Modulates Multisensory Integration.

J Cogn Neurosci 2018 Dec 18:1-15. Epub 2018 Dec 18.

University College London.

Multisensory integration processes are fundamental to our sense of self as embodied beings. Bodily illusions, such as the rubber hand illusion (RHI) and the size-weight illusion (SWI), allow us to investigate how the brain resolves conflicting multisensory evidence during perceptual inference in relation to different facets of body representation. In the RHI, synchronous tactile stimulation of a participant's hidden hand and a visible rubber hand creates illusory body ownership; in the SWI, the perceived size of the body can modulate the estimated weight of external objects. Read More

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http://dx.doi.org/10.1162/jocn_a_01366DOI Listing
December 2018

Reversible conduction failure on the deep tendon reflex response recording in early Guillain-Barré syndrome.

Clin Neurophysiol Pract 2018 3;3:159-163. Epub 2018 Nov 3.

Service of Neurology, University Hospital "Marqués de Valdecilla (IDIVAL)", University of Cantabria and "Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED)", Santander, Spain.

Objective: To describe the case of a patient with Guillain-Barré syndrome (GBS) showing early reversible conduction failure (RCF) detected by means of serial deep tendon reflex response (T-reflex) study.

Methods: A 36-year-old woman had a 5-day history of foot and hand paresthesias ascending to thighs and arms, throbbing interscapular and neck pain, mild to moderate tetraparesis, and areflexia. Nerve conduction studies (NCS) were performed on days 7 and 33 after onset. Read More

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http://dx.doi.org/10.1016/j.cnp.2018.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247394PMC
November 2018

Optimization of Proprioceptive Stimulation Frequency and Movement Range for fMRI.

Front Hum Neurosci 2018 3;12:477. Epub 2018 Dec 3.

Department of Neuroscience and Biomedical Engineering (NBE), Aalto University, Espoo, Finland.

For vision, audition and tactile sense, the optimal stimulus frequency for fMRI is somewhat known. For proprioception, i.e. Read More

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http://dx.doi.org/10.3389/fnhum.2018.00477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286983PMC
December 2018

Vascular Gap Junctions Contribute to Forepaw Stimulation-Induced Vasodilation Differentially in the Pial and Penetrating Arteries in Isoflurane-Anesthetized Rats.

Front Mol Neurosci 2018 3;11:446. Epub 2018 Dec 3.

Department of Autonomic Neuroscience, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.

Somatosensory stimulation causes dilation of the pial and penetrating arteries and an increase in cerebral blood flow (CBF) in the representative region of the somatosensory cortex. As an underlying mechanism for such stimulation-induced increases in CBF, cerebral artery dilation has been thought to propagate in the vascular endothelium from the parenchyma to the brain surface. Vascular gap junctions may propagate vasodilation. Read More

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http://dx.doi.org/10.3389/fnmol.2018.00446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286957PMC
December 2018

Effect of sleep restriction on somatosensory sensitivity including occlusal sensation in the orofacial area.

J Prosthodont Res 2018 Dec 14. Epub 2018 Dec 14.

Division of Oral Function and Rehabilitation, Department of Oral Health Science, Nihon University School of Dentistry at Matsudo, Matsudo, Japan.

Purpose: To investigate the effect of sleep restriction on somatosensory sensitivity related to occlusion.

Methods: Twelve healthy participants participated in an experimental voluntary total sleep restriction (SR) study. In a study design, they were invited to sleep as usual, normal sleep (NS) or to restrict their sleep for four nights. Read More

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http://dx.doi.org/10.1016/j.jpor.2018.11.005DOI Listing
December 2018

Peripheral sensory information and postural control in children with strabismus.

Gait Posture 2018 Sep 23;65:197-202. Epub 2018 Jul 23.

School of Physiotherapy, University of Otago, Dunedin, New Zealand.

Background: Sensory feedback from the visual system along with the vestibular and somatosensory systems is essential for the regulation of normal postural control. Children with strabismus and, therefore, with abnormal binocular vision, may have an altered perception of space and use different sets of cues to determine depth perception when compared with children without strabismus.

Objective: To explore the postural control of children with and without strabismus, when the three sensory systems are challenged. Read More

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http://dx.doi.org/10.1016/j.gaitpost.2018.07.173DOI Listing
September 2018

Effect of force magnitude of touch on the components of postural sway.

Gait Posture 2018 Sep 28;65:15-19. Epub 2018 Jun 28.

Graduate Program in Physical Therapy, São Paulo City University, Brazil; Department of Kinesiology, The Pennsylvania State University, University Park, PA, USA; Department of Neurology, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, PA, USA. Electronic address:

Background: Lightly touching the tip of the index finger on an external surface reduces the postural sway during upright standing due to the additional somatosensory information provided by the touch to the postural control system. But when the individuals apply more force, it provides more mechanical support. However, because most of the studies investigated only two levels of force, whether the control mechanisms of postural sway are affected by the different force levels was unknown. Read More

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http://dx.doi.org/10.1016/j.gaitpost.2018.06.164DOI Listing
September 2018

Towards a supervised classification of neocortical interneuron morphologies.

BMC Bioinformatics 2018 Dec 17;19(1):511. Epub 2018 Dec 17.

Departamento de Inteligencia Artificial, Universidad Politécnica de Madrid, Boadilla del Monte, 28660, Spain.

Background: The challenge of classifying cortical interneurons is yet to be solved. Data-driven classification into established morphological types may provide insight and practical value.

Results: We trained models using 217 high-quality morphologies of rat somatosensory neocortex interneurons reconstructed by a single laboratory and pre-classified into eight types. Read More

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http://dx.doi.org/10.1186/s12859-018-2470-1DOI Listing
December 2018

Menthol-induced facilitation of cerebrocortical excitatory propagation induced by air puff stimulation of the nasal cavity in the rat: An optical imaging study.

Neurosci Lett 2018 Dec 13. Epub 2018 Dec 13.

Department of Pharmacology, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-8310, Japan; Division of Oral and Craniomaxillofacial Research, Dental Research Center, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-8310, Japan; Molecular Dynamics Imaging Unit, RIKEN Center for Life Science Technologies, 6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.

Temperature plays a critical role in the sensation of airflow in the nasal mucosa. Neural activities of the ethmoidal nerve, a trigeminal afferent, responding to airflow are suppressed by warm airflow, whereas cold airflow enhances the ethmoidal nerve activities, which is mimicked by application of menthol, a cold-sensitive TRPM8 receptor agonist. However, it has been an open issue how menthol modulates the spatiotemporal profiles of neural activities of somatosensory cortical neurons. Read More

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http://dx.doi.org/10.1016/j.neulet.2018.12.018DOI Listing
December 2018

A neural substrate of early response capture during conflict tasks in sensory areas.

Neuropsychologia 2018 Dec 13. Epub 2018 Dec 13.

Integrative Model-based Cognitive Neuroscience Research Unit, University of Amsterdam, 1018 WS, the Netherlands.

Studies that aim to understand the neural correlates of response conflicts commonly probe frontal brain areas associated with controlled inhibition and decision processes. However, untimely fast conflict errors happen even before these top-down processes are engaged. The dual-route model proposes that during conflict tasks, as soon as the stimulus is presented, two early processes are immediately at play. Read More

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http://dx.doi.org/10.1016/j.neuropsychologia.2018.12.009DOI Listing
December 2018

Physical exercise enhances adult cortical plasticity in a neonatal rat model of hypoxic-ischemic injury: Evidence from BOLD-fMRI and electrophysiological recordings.

Neuroimage 2018 Dec 12. Epub 2018 Dec 12.

Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, 06351, South Korea; Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 06351, South Korea; Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, South Korea; Animal Research and Molecular Imaging, Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, 06351, South Korea; Department of Global Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea. Electronic address:

Neuroplasticity is considered essential for recovery from brain injury in developing brains. Recent studies indicate that it is especially effective during early postnatal development and during the critical period. The current study used functional magnetic resonance imaging (fMRI) and local field potential (LFP) electrophysiological recordings in rats that experienced neonatal hypoxic-ischemic (HI) injury during the critical period to demonstrate that physical exercise (PE) can improve cortical plasticity even when performed during adulthood, after the critical period. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2018.12.019DOI Listing
December 2018
1 Read

Power and phase coherence in sensorimotor mu and temporal lobe alpha components during covert and overt syllable production.

Exp Brain Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Hearing, Speech, and Language Sciences, Gallaudet University, 800 Florida Ave, Washington, DC, USA.

The sensorimotor dorsal stream is known to activate in both overt and covert speech production. However, overt production produces sensory consequences that are absent during covert production. Thus, the purpose of the current study is to investigate differences in dorsal stream activity between these two production conditions across the time course of utterances. Read More

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http://dx.doi.org/10.1007/s00221-018-5447-4DOI Listing
December 2018

Cold evoked potentials: Acquisition from cervical dermatomes.

Neurophysiol Clin 2018 Dec 11. Epub 2018 Dec 11.

Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Forchstrasse 340, 8008 Zurich, Switzerland. Electronic address:

Introduction: Cold evoked potentials (CEPs) represent a novel technique to assess the integrity of cold-specific pathways within the somatosensory system. So far an objective assessment of these pathways has not been implemented into the clinical routine. Specifically, CEPs may help to elucidate the pathophysiological underpinnings of altered cold processing in neurological diseases. Read More

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http://dx.doi.org/10.1016/j.neucli.2018.11.003DOI Listing
December 2018
1 Read

Anomalous Bodily Maps of Emotions in Schizophrenia.

Schizophr Bull 2018 Dec 14. Epub 2018 Dec 14.

Department of Psychology, Vanderbilt University, Nashville, TN.

Objective: Embodied emotions arise from interoceptive and somatosensory processes, and are essential to the development of a stable sense of self. Emotional embodiment is therefore inherently interwoven with our sense of bodily self-awareness, and allows us to navigate complex social situations. Given that the core feature of schizophrenia (SZ) is characterized by the presence of bodily self-disturbances and social-emotional deficits, we hypothesized that embodiment of emotion would be disrupted in SZ. Read More

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https://academic.oup.com/schizophreniabulletin/advance-artic
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http://dx.doi.org/10.1093/schbul/sby179DOI Listing
December 2018
2 Reads

Synaptic potentiation and rapid antidepressant response to ketamine in treatment-resistant major depression: A replication study.

Psychiatry Res Neuroimaging 2018 Sep 12;283:64-66. Epub 2018 Sep 12.

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.

Preclinical and clinical evidence has demonstrated that ketamine has rapid antidepressant effects. Studies using pre-treatment with an AMPA inhibitor suggest that enhancing AMPA throughput is crucial to ketamine's effects, including increases in both basal and evoked gamma power. This study sought to replicate previous findings of increased gamma response to a somatosensory stimulus at 230 min and Day 1 in ketamine responders versus non-responders in 31 depressed subjects and 25 healthy controls. Read More

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http://dx.doi.org/10.1016/j.pscychresns.2018.09.001DOI Listing
September 2018
1 Read

Somatosensory evoked potential changes and decompression timing for spinal cord function recovery and evoked potentials in rats with spinal cord injury.

Brain Res Bull 2018 Dec 11;146:7-11. Epub 2018 Dec 11.

Department of Anesthesiology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, China. Electronic address:

Objective: The study aimed to evaluate changes of somatosensory evoked potentials and the effects of decompression timing on spinal cord recovery and evoked potentials by measuring the somatosensory evoked potentials of rats with spinal cord injury at different time points.

Methods: A total of 70 SD rats were divided into the control group (group A) and the experimental group. The experimental groups included group B-D according to the severity of spinal cord injury. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2018.12.003DOI Listing
December 2018
2.718 Impact Factor

Cervical Spinal Cord Stimulation for the Vegetative State: A Preliminary Result of 12 Cases.

Neuromodulation 2018 Dec 13. Epub 2018 Dec 13.

Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, China.

Objectives: Data on the treatment of the vegetative state (VS) with cervical spinal cord stimulation (cSCS) are limited and prognostic factors are inconclusive. In this study, we present our experience of treating 12 VS patients with cSCS and discuss the prognostic factors.

Methods: Twelve VS patients were enrolled. Read More

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http://dx.doi.org/10.1111/ner.12903DOI Listing
December 2018

Sensory coding is impaired in rat absence epilepsy.

J Physiol 2018 Dec 13. Epub 2018 Dec 13.

Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, F-38000, Grenoble, France.

Key Points: Absence epilepsy is characterized by the occurrence of spike-and-wave discharges concomitant with an alteration of consciousness and associated with cognitive comorbidities. In a genetic model of absence epilepsy in the rat, the GAERS, we showed that spike-and-wave discharges are initiated in the barrel field primary somatosensory cortex that codes whisker-related information therefore playing an essential role in rodents' interactions with their environment. Sensory-information processing is impaired in the epileptic barrel field primary somatosensory cortex of GAERS with a delayed sensory-evoked potential and a duplicated neuronal response to whisker-stimulation in in vivo extracellular recordings. Read More

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http://dx.doi.org/10.1113/JP277297DOI Listing
December 2018

MISC: missing imputation for single-cell RNA sequencing data.

BMC Syst Biol 2018 Dec 14;12(Suppl 7):114. Epub 2018 Dec 14.

Joint Bioinformatics Program, University of Arkansas Little Rock George Washington Donaghey College of Engineering & IT and University of Arkansas for Medical Sciences, Little Rock, AR, 72204, USA.

Background: Single-cell RNA sequencing (scRNA-seq) technology provides an effective way to study cell heterogeneity. However, due to the low capture efficiency and stochastic gene expression, scRNA-seq data often contains a high percentage of missing values. It has been showed that the missing rate can reach approximately 30% even after noise reduction. Read More

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http://dx.doi.org/10.1186/s12918-018-0638-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293493PMC
December 2018
1 Read

Deficits in Behavioral Functions of Intact Barrel Cortex Following Lesions of Homotopic Contralateral Cortex.

Front Syst Neurosci 2018 22;12:57. Epub 2018 Nov 22.

National Brain Research Centre, Manesar, India.

Focal unilateral injuries to the somatosensory whisker barrel cortex have been shown cause long-lasting deficits in the activity and experience-dependent plasticity of neurons in the intact contralateral barrel cortex. However, the long-term effect of these deficits on behavioral functions of the intact contralesional cortex is not clear. In this study, we used the "Gap-crossing task" a barrel cortex-dependent, whisker-sensitive, tactile behavior to test the hypothesis that unilateral lesions of the somatosensory cortex would affect behavioral functions of the intact somatosensory cortex and degrade the execution of a bilaterally learnt behavior. Read More

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http://dx.doi.org/10.3389/fnsys.2018.00057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262316PMC
November 2018

Dendritic spines in early postnatal Fragile X mice are insensitive to novel sensory experience.

J Neurosci 2018 Dec 6. Epub 2018 Dec 6.

Departments of Neurology

Autism spectrum disorders (ASD) are often associated with atypical sensory processing and sensory hypersensitivity, which can lead to maladaptive behaviors, such as tactile defensiveness. Such altered sensory perception in ASD could arise from disruptions in experience-dependent maturation of circuits during early brain development. Here, we tested the hypothesis that synaptic structures of primary somatosensory cortex (S1) neurons in Fragile X syndrome (FXS), which is a common inherited cause of autism, are not modulated by novel sensory information during development. Read More

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http://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.1734-1
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http://dx.doi.org/10.1523/JNEUROSCI.1734-18.2018DOI Listing
December 2018
1 Read

Machine learning-based prediction of clinical pain using multimodal neuroimaging and autonomic metrics.

Pain 2018 Oct 17. Epub 2018 Oct 17.

Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States.

Although self-report pain ratings are the gold standard in clinical pain assessment, they are inherently subjective in nature and significantly influenced by multidimensional contextual variables. Although objective biomarkers for pain could substantially aid pain diagnosis and development of novel therapies, reliable markers for clinical pain have been elusive. In this study, individualized physical maneuvers were used to exacerbate clinical pain in patients with chronic low back pain (N = 53), thereby experimentally producing lower and higher pain states. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001417DOI Listing
October 2018
2 Reads

From anatomy to function: the role of the somatosensory cortex in emotional regulation.

Braz J Psychiatry 2018 Dec 6. Epub 2018 Dec 6.

Mood Disorders Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Canada.

 : Since the pioneering work of Penfield and his colleagues in the 1930s, the somatosensory cortex, which is located on the postcentral gyrus, has been known for its central role in processing sensory information from various parts of the body. More recently, a converging body of literature has shown that the somatosensory cortex also plays an important role in each stage of emotional processing, including identification of emotional significance in a stimulus, generation of emotional states, and regulation of emotion. Importantly, studies conducted in individuals suffering from mental disorders associated with abnormal emotional regulation, such as major depression, bipolar disorder, schizophrenia, post-traumatic stress disorder, anxiety and panic disorders, specific phobia, obesity, and obsessive-compulsive disorder, have found structural and functional changes in the somatosensory cortex. Read More

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http://dx.doi.org/10.1590/1516-4446-2018-0183DOI Listing
December 2018
1 Read

An Investigation and Suggestions for the Improvement of Brain Death Determination in China.

Chin Med J (Engl) 2018 Dec;131(24):2910-2914

Department of Neurology, Xuanwu Hospital, Capital Medical University, National Health Commission of the People's Republic of China/Brain Injury Evaluation Quality Control Centre, Beijing 100053, China.

Background: Brain death is the irreversible cessation of the function of the brain including the brainstem. In 2013, the Brain Injury Evaluation Quality Control Centre (BQCC) of the National Health and Family Planning Commission issued criteria and practical guidelines for the determination of brain death. This study aimed to evaluate whether the institutions have adopted these guidelines and to make suggestions for the improvement of the current criteria and practical guidelines for brain death determination in China. Read More

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http://www.cmj.org/text.asp?2018/131/24/2910/247193
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http://dx.doi.org/10.4103/0366-6999.247193DOI Listing
December 2018
1 Read

Critical Role of Somatosensation in Postural Control Following Spaceflight: Vestibularly Deficient Astronauts Are Not Able to Maintain Upright Stance During Compromised Somatosensation.

Front Physiol 2018 27;9:1680. Epub 2018 Nov 27.

Human Research Program, Johnson Space Center, National Aeronautics and Space Administration, Houston, TX, United States.

The free-fall of orbital spaceflight effectively removes the gravitational vector used as a primary spatial orientation reference on Earth. Sustained absence of this reference drives adaptive changes in the internal perception-action models of the central nervous system (CNS), most notably in the processing of the vestibular otolith inputs. Upon landing, the return of the gravitational signal triggers a re-adaptation that restores terrestrial performance; however, during this period, the individual suffers from a functional vestibular deficiency. Read More

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http://dx.doi.org/10.3389/fphys.2018.01680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277541PMC
November 2018

Visual-Somatosensory Integration and Quantitative Gait Performance in Aging.

Front Aging Neurosci 2018 27;10:377. Epub 2018 Nov 27.

Division of Cognitive and Motor Aging, Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, United States.

The ability to integrate information across sensory modalities is an integral aspect of mobility. Yet, the association between visual-somatosensory (VS) integration and gait performance has not been well-established in aging. A total of 333 healthy older adults (mean age 76. Read More

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http://dx.doi.org/10.3389/fnagi.2018.00377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277592PMC
November 2018

Long-Term Effects of Early Life Seizures on Endogenous Local Network Activity of the Mouse Neocortex.

Front Synaptic Neurosci 2018 27;10:43. Epub 2018 Nov 27.

Biomedical Research Foundation of the Academy of Athens, Athens, Greece.

Understanding the long term impact of early life seizures (ELS) is of vital importance both for researchers and clinicians. Most experimental studies of how seizures affect the developing brain have drawn their conclusions based on changes detected at the cellular or behavioral level, rather than on intermediate levels of analysis, such as the physiology of neuronal networks. Neurons work as part of networks and network dynamics integrate the function of molecules, cells and synapses in the emergent properties of brain circuits that reflect the balance of excitation and inhibition in the brain. Read More

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http://dx.doi.org/10.3389/fnsyn.2018.00043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277496PMC
November 2018

Prospective study of clinical, neurophysiological and urodynamic findings in multiple scleosis patients undergoing percutaneous transluminal venous angioplasty.

Clin Neurophysiol 2018 Nov 26;130(1):138-144. Epub 2018 Nov 26.

Department of Medicine, Surgery and Neuroscience, Unit of Neurology and Clinical Neurophysiology, University of Siena, Italy. Electronic address:

Objective: Verify whether Percutaneous Transluminal Angioplasty (PTA) may affect neural conduction properties in Multiple Sclerosis (MS) patients, thereby modifying patients' disability, with prospective neurophysiological, urodynamic, clinical and subjective well-being evaluations.

Methods: In 55 out of 72 consecutively screened MS patients, the following procedures were carried out before (T0), at 2-6 months (T1) and at 6-15 months (T2) after a diagnostic phlebography, eventually followed by the PTA intervention if chronic cerebrospinal venous insufficiency (CCSVI) was diagnosed: clinical/objective evaluation (Expanded Disability Status Scale, EDSS), ratings of subjective well-being, evaluation of urodynamic functions and multimodal EPs (visual, acoustic, upper and lower limbs somatosensory and motor evoked potentials).

Results: The number of dropouts was relatively high, and a complete set of neurophysiological and clinical data remained available for 37 patients (19 for urological investigations). Read More

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http://dx.doi.org/10.1016/j.clinph.2018.10.015DOI Listing
November 2018

Brain MRI Lesions are Related to Bowel Incontinence in Multiple Sclerosis.

J Neuroimaging 2018 Dec 11. Epub 2018 Dec 11.

Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

Background And Purpose: Bowel incontinence in multiple sclerosis might be associated with specific lesion sites. This study intended to determine associations between bowel incontinence and cerebral multiple sclerosis lesions using a voxel-wise lesion symptom mapping analysis.

Methods: We conducted a retrospective study of multiple sclerosis patients with self-reported bowel incontinence and matched controls. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jon.12589
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http://dx.doi.org/10.1111/jon.12589DOI Listing
December 2018
1 Read

Emergence of Coordinated Activity in the Developing Entorhinal-Hippocampal Network.

Cereb Cortex 2018 Dec 7. Epub 2018 Dec 7.

INMED, Aix-Marseille University, INSERM, Marseille, France.

Correlated activity in the entorhinal-hippocampal neuronal networks, supported by oscillatory and intermittent population activity patterns is critical for learning and memory. However, when and how correlated activity emerges in these networks during development remains largely unknown. Here, we found that during the first postnatal week in non-anaesthetized head-restrained rats, activity in the superficial layers of the medial entorhinal cortex (MEC) and hippocampus was highly correlated, with intermittent population bursts in the MEC followed by early sharp waves (eSPWs) in the hippocampus. Read More

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https://academic.oup.com/cercor/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/cercor/bhy309DOI Listing
December 2018
4 Reads

Somatosensory Plasticity in Pediatric Cerebral Palsy following Constraint-Induced Movement Therapy.

Neural Plast 2018 8;2018:1891978. Epub 2018 Nov 8.

Department of Hearing and Speech Sciences & Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN, USA.

Cerebral palsy (CP) is predominantly a disorder of movement, with evidence of sensory-motor dysfunction. CIMT is a widely used treatment for hemiplegic CP. However, effects of CIMT on somatosensory processing remain unclear. Read More

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http://dx.doi.org/10.1155/2018/1891978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250030PMC
November 2018

Identifying the pathways required for coping behaviours associated with sustained pain.

Nature 2018 Dec 10. Epub 2018 Dec 10.

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

Animals and humans display two types of response to noxious stimuli. The first includes reflexive defensive responses that prevent or limit injury; a well-known example of these responses is the quick withdrawal of one's hand upon touching a hot object. When the first-line response fails to prevent tissue damage (for example, a finger is burnt), the resulting pain invokes a second-line coping response-such as licking the injured area to soothe suffering. Read More

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http://www.nature.com/articles/s41586-018-0793-8
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http://dx.doi.org/10.1038/s41586-018-0793-8DOI Listing
December 2018
57 Reads
42.351 Impact Factor

Correlates of Residual Limb Pain: from Residual Limb Length and Usage to Metabolites and Activity in Secondary Somatosensory Cortex.

IEEE Trans Neural Syst Rehabil Eng 2018 Dec 5. Epub 2018 Dec 5.

Most recent studies attribute residual limb pain to peripheral pathological changes of the stump. However, in this study, we focus on its associations with the residual limb length, usage as well as the metabolic and functional alterations of the brain. The secondary somatosensory cortex (S2), one important area involved in pain intensity discrimination, was selected as the region of interest. Read More

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http://dx.doi.org/10.1109/TNSRE.2018.2885146DOI Listing
December 2018

Transcranial alternating current stimulation at 10 Hz modulates response bias in the Somatic Signal Detection Task.

Int J Psychophysiol 2018 Dec 6;135:106-112. Epub 2018 Dec 6.

School of Psychology, University of Leeds, Leeds LS2 9JT, UK. Electronic address:

Ongoing, pre-stimulus oscillatory activity in the 8-13 Hz alpha range has been shown to correlate with both true and false reports of peri-threshold somatosensory stimuli. However, to directly test the role of such oscillatory activity in behaviour, it is necessary to manipulate it. Transcranial alternating current stimulation (tACS) offers a method of directly manipulating oscillatory brain activity using a sinusoidal current passed to the scalp. Read More

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http://dx.doi.org/10.1016/j.ijpsycho.2018.12.001DOI Listing
December 2018

Somatosensory temporal discrimination is impaired in fibromyalgia.

J Clin Neurosci 2018 Oct 24. Epub 2018 Oct 24.

Gazi University, Faculty of Medicine, Department of Neurology, Motor Control Laboratory, Besevler, 06510 Ankara, Turkey.

Objective: Fibromyalgia is the prototypical central sensitivity syndrome which is associated with increased sensitivity to pain and other stimuli. In this study, we aimed to evaluate whether somatosensory temporal discrimination ability, which provides information about central processing of sensory stimuli, was impaired in patients with fibromyalgia.

Methods: Fifteen patients with fibromyalgia and 15 healthy subjects participated in the study. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.10.067DOI Listing
October 2018

The diagnostic accuracy of somatosensory evoked potentials in evaluating neurological deficits during 1057 lumbar interbody fusions.

J Clin Neurosci 2018 Dec 4. Epub 2018 Dec 4.

Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

Background: Lumbar interbody spinal fusion (LIF) surgeries are performed to treat or prevent back pain in patients with degenerated intervertebral discs and a variety of spinal diseases. However, post-operative neurological complications may ensue. Intraoperative monitoring techniques have been used to predict and potentially reduce the risk of complications. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.10.140DOI Listing
December 2018

Space counts! Brain correlates of spatial and numerical representations in synaesthesia.

Cortex 2018 Nov 20. Epub 2018 Nov 20.

Department of Psychology and Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer Sheva, Israel.

Over-learned semantic representations, such as numbers, are strongly associated with space in normal cognition, and in the phenomenon called number-space synaesthesia. In number-space synaesthesia, numbers are linked to spatial locations in an idiosyncratic way. Synaesthetes report numbers as belonging to a specific location, or feelings that a specific location is the right location for that number. Read More

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http://dx.doi.org/10.1016/j.cortex.2018.11.006DOI Listing
November 2018

Pain characterization and response to palliative care in dogs with naturally-occurring appendicular osteosarcoma: An open label clinical trial.

PLoS One 2018 6;13(12):e0207200. Epub 2018 Dec 6.

GREPAQ (Groupe de recherche en pharmacologie animale du Québec), Department of biomedical sciences, Faculty of Veterinary Medicine, Université de Montréal, Saint-Hyacinthe, Quebec, Canada.

This study aimed to characterize bone cancer pain (quantitative sensory testing (QST), stance asymmetry index, actimetry, scores of pain and quality of life (QoL)) in dogs with appendicular osteosarcoma (OSA), and to evaluate a stepwise palliative analgesic treatment. The pain profile of thirteen client-owned dogs with OSA was compared with seven healthy dogs. Dogs with OSA were then enrolled in a prospective, open-label, clinical trial. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207200PLOS
December 2018
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A databank for intracellular electrophysiological mapping of the adult somatosensory cortex.

Gigascience 2018 Dec 6. Epub 2018 Dec 6.

Department of Neurophysiology, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen - the Netherlands.

Background: Neurons in the supragranular layers of the somatosensory cortex integrate sensory (bottom-up) and cognitive/perceptual (top-down) information as they orchestrate communication across cortical columns. It has been inferred, based on intracellular recordings from juvenile animals, that supragranular neurons are electrically mature by the fourth postnatal week. However, the dynamics of the neuronal integration in the adulthood is largely unknown. Read More

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https://academic.oup.com/gigascience/advance-article/doi/10.
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http://dx.doi.org/10.1093/gigascience/giy147DOI Listing
December 2018
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Individual optimal attentional strategy during implicit motor learning boosts frontoparietal neural processing efficiency: A functional near-infrared spectroscopy study.

Brain Behav 2018 Dec 5:e01183. Epub 2018 Dec 5.

Department of Neurosurgery, Jichi Medical University, Shimotsuke, Japan.

Introduction: Optimal focus of attention is a crucial factor for improving motor learning. Most previous studies have shown that directing attention to movement outcome (external focus; EF) is more effective than directing attention to body movement itself (internal focus; IF). However, our recent studies demonstrated that the optimal attentional strategy in healthy and clinical populations varies depending on individual motor imagery ability. Read More

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http://dx.doi.org/10.1002/brb3.1183DOI Listing
December 2018
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miR-202 modulates the progression of neuropathic pain through targeting RAP1A.

J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.

Department of Anestheiology, Liaocheng People's Hospital, Liaocheng, Shandong, China.

Neuropathic pain is a somatosensory disorder which is caused by disease or nerve injury that affects the nervous system. microRNAs (miRNAs) are proved to play crucial roles in the development of neuropathic pain. However, the role of miR-202 in neuropathic pain is still unknown. Read More

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http://doi.wiley.com/10.1002/jcb.27025
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http://dx.doi.org/10.1002/jcb.27025DOI Listing
December 2018
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A comparison of biological activity of commercially available purified native botulinum neurotoxin serotypes A1 to F1 in vitro, ex vivo, and in vivo.

Pharmacol Res Perspect 2018 12 22;6(6):e00446. Epub 2018 Nov 22.

Ipsen Bioinnovation Abingdon Oxford UK.

Botulinum neurotoxin (BoNT) is a major therapeutic agent. Of seven native BoNT serotypes (A to G), only A and B are currently used in the clinic. Here we compared the potency of commercially available purified native serotypes A1 to F1 across in vitro, ex vivo, and in vivo assays. Read More

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http://dx.doi.org/10.1002/prp2.446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261930PMC
December 2018
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Altered pain processing in people with type I and II diabetes: a protocol for a systematic review and meta-analysis of pain threshold and pain modulation mechanisms.

Syst Rev 2018 Dec 5;7(1):222. Epub 2018 Dec 5.

The Hopkins Centre, Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia.

Background: Peripheral neuropathies are a common complication in patients with diabetes. Changes in nerve function and central pain processing can be quantified by assessing pain thresholds and pain modulation mechanisms.

Aim: To summarise the literature which compares pain thresholds and pain modulation mechanisms in people with diabetes without neuropathies, with non-painful diabetic neuropathies and with painful diabetic neuropathies, and in people without diabetes. Read More

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https://systematicreviewsjournal.biomedcentral.com/articles/
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http://dx.doi.org/10.1186/s13643-018-0895-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280339PMC
December 2018
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Persistent reduction in sialylation of cerebral glycoproteins following postnatal inflammatory exposure.

J Neuroinflammation 2018 Dec 5;15(1):336. Epub 2018 Dec 5.

Department of Paediatrics, Sainte-Justine Hospital Research Center, Université de Montréal, Montreal, H3T 1C5, QC, Canada.

Background: The extension of sepsis encompassing the preterm newborn's brain is often overlooked due to technical challenges in this highly vulnerable population, yet it leads to substantial long-term neurodevelopmental disabilities. In this study, we demonstrate how neonatal neuroinflammation following postnatal E. coli lipopolysaccharide (LPS) exposure in rat pups results in persistent reduction in sialylation of cerebral glycoproteins. Read More

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http://dx.doi.org/10.1186/s12974-018-1367-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282350PMC
December 2018
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Robot-assisted gait training effectively improved lateropulsion in subacute stroke patients: a single-blinded randomized controlled trial.

Eur J Phys Rehabil Med 2018 Dec 3. Epub 2018 Dec 3.

Department of Rehabilitation Medicine, Wonkwang University School of Medicine, Iksan, Republic of Korea -

Background: Some stroke patients are known to use nonparetic extremities to push toward the paretic side, a movement known as lateropulsion. Lateropulsion impairs postural balance and interferes with rehabilitation.

Aim: The aim of the present study was to investigate the effect of robot-assisted gait training (RAGT) on recovery from lateropulsion compared with conventional physical therapy (CPT). Read More

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http://dx.doi.org/10.23736/S1973-9087.18.05077-3DOI Listing
December 2018

Pioglitazone, a PPARγ agonist, reduces cisplatin-evoked neuropathic pain by protecting against oxidative stress.

Pain 2018 Nov 29. Epub 2018 Nov 29.

Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN.

Painful peripheral neuropathy is a dose-limiting side effect of cisplatin treatment. Using a murine model of cisplatin-induced hyperalgesia, we determined whether a PPARγ synthetic agonist, pioglitazone, attenuated the development of neuropathic pain and identified underlying mechanisms. Cisplatin produced mechanical and cold hyperalgesia and decreased electrical thresholds of Aδ and C-fibers, which were attenuated by co-administration of pioglitazone (10 mg/kg, i. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001448DOI Listing
November 2018
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Effects of Tonic Spinal Cord Stimulation on Sensory Perception in Chronic Pain Patients: A Systematic Review.

Neuromodulation 2018 Dec 2. Epub 2018 Dec 2.

Centre de recherche du CHU de Québec - Université Laval, Axe neurosciences, Quebec city, Quebec, Canada.

Objectives: Even if spinal cord stimulation (SCS) is widely used and effective in treating intractable chronic neuropathic pain conditions, little is known about its possible impacts on sensory perception. Quantitative sensory testing (QST) is a useful tool to assess this issue. The aim of this study was to review the impact of tonic SCS on somatosensory perception quantified by QST in chronic pain patients. Read More

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http://dx.doi.org/10.1111/ner.12893DOI Listing
December 2018

A Single-Blinded Trial Using Resting-State Functional Magnetic Resonance Imaging of Brain Activity in Patients with Type 2 Diabetes and Painful Neuropathy.

Diabetes Ther 2018 Nov 30. Epub 2018 Nov 30.

Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.

About two-thirds of patients with painful diabetic neuropathy (PDN) suffer from anxiety and/or depression disorders. However, the pathogenesis of PDN is unclear, in particular with respect to the mechanism associated with the central nervous system. We used the neuroimaging techniques of fraction amplitude of low-frequency fluctuation (fALFF) and regional homogeneity of resting-state functional magnetic resonance imaging (fMRI) to explore the brain activity in patients with PDN. Read More

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http://dx.doi.org/10.1007/s13300-018-0534-xDOI Listing
November 2018

Paradoxical, causal effects of sensory gain modulation on motor inhibitory control - a tDCS, EEG-source localization study.

Sci Rep 2018 Nov 30;8(1):17486. Epub 2018 Nov 30.

Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Germany.

Response inhibition is a key component of executive functioning, but the role of perceptual processes has only recently been focused. Although the interrelation of incoming information and resulting behavioural (motor) effects is well-known to depend on gain control mechanisms, the causal role of sensory gain modulation for response inhibition is elusive. We investigate it using a somatosensory response inhibition (Go/Nogo) task and examine the effects of parietal (somatosensory) cathodal and sham tDCS stimulation on a behavioural and neurophysiological level. Read More

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http://dx.doi.org/10.1038/s41598-018-35879-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269458PMC
November 2018
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