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Zh Nevrol Psikhiatr Im S S Korsakova 2022 ;122(6):55-62

Pirogov Russian National Research Medical University, Moscow, Russia.

Objective: Determination of the dose-dependent effect of the Teraligen for various nosological forms of disorders in psychiatric practice and general medicine.

Material And Methods: Analysis of 98 publications included in the database of the RISC (2012-2021) with the identification of disorders (according to ICD-10) in which Teraligen is prescribed or can be used (in adults and children from the age of 7).

Results: Despite a rather long and successful history use, research work on the study drug Teraligen continues. Read More

Psychoneuroendocrinology 2022 Jun 17;143:105842. Epub 2022 Jun 17.

Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany; Charité Center for Internal Medicine and Dermatology, Department of Psychosomatic Medicine, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany; Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen, Germany. Electronic address:

Background: Nesfatin-1 has been described as an anorexigenic peptide. Comprehensive evidence also points towards an involvement of nesfatin-1 in the modulation of emotional pathways with a sex-specific regulation of nesfatin-1 in association with anxiety. Although the implication of nesfatin-1 in the regulation of food intake is well-established in animals, data in humans are lacking. Read More

Int J Environ Res Public Health 2022 Jun 16;19(12). Epub 2022 Jun 16.

Department of Psychology, Clinical Psychology with Focus on Psychotherapy Research, University of Zurich, Binzmühlestrasse 14, 8050 Zurich, Switzerland.

Cognitive behavioral therapy is an effective treatment for body dysmorphic disorder (BDD), but many patients do not receive appropriate treatment due to several treatment barriers and psychosocial care structures. Low-threshold interventions, including those from the field of e-mental health, could improve access to psychotherapy. In addition to internet-administered therapy, telephone-administered therapy may reduce treatment barriers, especially during the COVID-19 pandemic. Read More

Int J Environ Res Public Health 2022 Jun 10;19(12). Epub 2022 Jun 10.

Institute for Occupational, Social, and Environmental Medicine, Medical Faculty, RWTH Aachen University, Pauwelsstrasse 30, 52070 Aachen, Germany.

Unwelcome environmental changes can lead to psychological distress, known as "solastalgia". In Germany, the open-pit mining of brown coal results in environmental changes as well as in the resettlement of adjacent villages. In this study, we investigated the risk of open-pit mining for solastalgia and psychological disorders (e. Read More

Soc Psychiatry Psychiatr Epidemiol 2022 Jun 23. Epub 2022 Jun 23.

Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK.

Purpose: The COVID-19 pandemic may have exacerbated ethnic health inequalities, particularly in people with multiple long-term health conditions, the interplay with mental health is unclear. This study investigates the impact of the pandemic on the association of ethnicity and multimorbidity with mortality/service use among adults, in people living with severe mental illnesses (SMI).

Methods: This study will utilise secondary mental healthcare records via the Clinical Record Interactive Search (CRIS) and nationally representative primary care records through the Clinical Practice Interactive Research Database (CPRD). Read More

Turk Psikiyatri Derg 2022 ;33(2):133-138

Functional movement disorders (FMD) are abnormal involuntary movements that are not attributable to known neurological and neuroanatomical causes. In the past decade, FMD diagnoses have been based on positive factors that are inconsistent with neurological disorders and not on the exclusion of neurological disorders. In this report, we presented the case of a female patient who had been followed up for 4 years in multiple health centers with the diagnosis of a neurological disorder which was suspected in the previous 1 year to be of psychogenic origin. Read More

Nat Rev Dis Primers 2022 Jun 16;8(1):40. Epub 2022 Jun 16.

Orthod Craniofac Res 2022 Jun 11. Epub 2022 Jun 11.

Pediatric Dentistry and Orthodontics, Institute of Dentistry, University of Turku, Turku, Finland.

Objectives: To analyse the prevalence and distribution of craniofacial microsomia (CFM) cases in Finland and their most frequent comorbidities. The second aim was to analyse the patients' need for specialized healthcare services.

Materials And Methods: Data were gathered from two complementary registers: The Register of Congenital Malformations and the Care Register for Social Welfare and Health Care (Hilmo) of the Finnish Institute for Health and Welfare (THL). Read More

BMJ Case Rep 2022 Jun 7;15(6). Epub 2022 Jun 7.

Department of Internal Medicine, Regional Hospital of Bellinzona and Valleys, Ente Ospedaliero Cantonale, Bellinzona, Ticino, Switzerland.

Burning mouth syndrome (BMS) is a rare but serious medical condition with important psychiatric comorbidity and specific psychological correlates. Psychopathology related with BMS represents a real challenge for clinical decision-making. In this case, depression is the leading psychiatric diagnosis associated with patient's BMS somatic pain and is driven by anxiety and a dissociative functioning. Read More

Prog Brain Res 2022 14;272(1):143-151. Epub 2022 May 14.

Department of Neurosurgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX, United States. Electronic address:

Patients who display the neurological phenomena variously referred to as pseudoseizures, dissociative seizures, or psychogenic non-epileptic seizures present an important problem in the treatment of epilepsy. Their convulsive or non-convulsive episodes show no epileptiform activity on electroencephalography but are distressing and debilitating to patients so afflicted, and can be difficult to distinguish from classical epilepsy. It is important to make this distinction, as the treatment for pseudoseizures is typically cognitive behavioral therapy rather than anticonvulsant medication. Read More

Prog Brain Res 2022 18;272(1):105-123. Epub 2022 May 18.

Department of Neurosurgery, Research Center of Neurology, Moscow, Russian Federation.

Classification of pain syndromes is quite multifaceted. However, pathogenetic classification by which chronic pain syndromes are usually divided into nociceptive, neuropathic and psychogenic, is crucial in choosing treatment tactics. In modern classifications, psychogenic pain is distinguished from nociceptive pain (associated with direct tissue injury or damage) and neuropathic pain (in which lesion can only be determined morphologically). Read More

Birth Defects Res 2022 Jun 4. Epub 2022 Jun 4.

Institute of Medical Statistics and Computational Biology, University of Cologne, Cologne, Germany.

Background: As individuals with thalidomide embryopathy now reaching their 60's they undergo long-term sequelae of their prenatal damage and experience a wide range of secondary health problems, in particular chronic musculoskeletal pain, movement restrictions, and mental disorders. These health problems are having a negative impact on their life circumstances and their health-related quality of life (HRQOL).

Objective: The aim of this study was to determine the HRQOL in individuals with thalidomide embryopathy in comparison to individuals of the age-adjusted general population in Germany with and without chronic disease conditions (primary outcome). Read More

Int J Soc Psychiatry 2022 Jun 2:207640221097509. Epub 2022 Jun 2.

Department of Psychiatry, National Hospital Organization Shimofusa Psychiatric Medical Center, Chiba, Japan.

Background: The coronavirus disease 2019 (COVID-19) pandemic has resulted in a total upending of our daily lives. While anxiety and depression were frequently reported among the general population, the pandemic's impact on patients with mental health problems remains unknown.

Methods: A cross-sectional questionnaire survey involving 1,166 patients was conducted at one psychiatric hospital and one mental health clinic. Read More

Actas Esp Psiquiatr 2022 May 1;50(3):160-162. Epub 2022 May 1.

CS Martín de Vargas (Madrid).

Astasia-abasia was described by Paul Blocq as a psychogenic condition; later, several brain injuries have been described for its explanation too. Read More

J Psychosom Res 2022 Jul 19;158:110921. Epub 2022 Apr 19.

King's College London, Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, UK. Electronic address:

Objective: We explored moderators of cognitive behavioural therapy (CBT) treatment effects and predictors of outcome at 12-month follow-up in the CODES Trial (N = 368) comparing CBT plus standardised medical care (SMC) vs SMC-alone for dissociative seizures (DS).

Methods: We undertook moderator analyses of baseline characteristics to determine who had benefited from being offered CBT 12 months post-randomisation. Outcomes included: monthly DS frequency, psychosocial functioning (Work and Social Adjustment Scale - WSAS), and health-related quality of life (Mental Component Summary (MCS) and Physical Component Summary (PCS) SF-12v2 scores). Read More

Brain Nerve 2022 May;74(5):559-564

Department of Neurology, Hirosaki University Graduate School of Medicine.

In recent years, the term "functional" is starting to replace "psychogenic" when referring to a specific group of movement disorders, with an increasing emphasis being placed on the role of neurologists in the management of these disorders. These conditions are common and disabling, and sometimes difficult to diagnose. History taking and physical examination may highlight positive signs suggestive of diagnosis, which should not be based on exclusion. Read More

Brain Nerve 2022 May;74(5):553-558

Jichiidai Station Brain Clinic.

The most important factor in the treatment of functional movement disorders is the initial discussion between the doctor and the patient, wherein the doctor must inform the patient regarding their diagnosis and obtain their consent. To obtain consent, explanations must be tailored to the patient's knowledge. To do so, it is important to know the patient. Read More

Epilepsy Behav 2022 Jul 14;132:108710. Epub 2022 May 14.

Neurosciences Research Centre, St George's University of London, London, UK; Atkinson Morley Regional Neuroscience Centre, St George's Hospital, London, UK; Department of Clinical and Experimental Epilepsy, Institute of Neurology, UCL, National Hospital for Neurology and Neurosurgery, UCLH, Epilepsy Society, UK. Electronic address:

Background: Functional seizures (FS), otherwise known as psychogenic nonepileptic seizures (PNES), are a common symptom presenting to neurology and epilepsy clinics. There is a pressing need for further research to understand the neurobiology of FS to develop mechanistically targeted treatments. Joint hypermobility is an expression of variation in connective tissue structure along a spectrum, and it has received increasing attention in functional neurological disorders, but there is lack of evidence of its relevance in FS. Read More

Gen Hosp Psychiatry 2022 Jul-Aug;77:92-101. Epub 2022 Apr 18.

Department of Psychology, University of Delhi, New Delhi, India.

Objective: Individuals seeking treatment for physical symptoms having unknown etiology are common in the primary healthcare setup. Factors such as biomedical, environmental, social, and psychological ones are expected to play an important role in the treatment of Medically Unexplained Physical Symptoms (MUPS). Therefore, this systematic review and meta-analysis aimed to investigate the efficacy of psychological interventions for the treatment of MUPS. Read More

J Neuropsychiatry Clin Neurosci 2022 May 17:appineuropsych21080213. Epub 2022 May 17.

Neuropsychiatry Research and Education Group, Institute of Psychiatry, Psychology and Neuroscience, King's College London (Butler, Pick, Nicholson); Institute of Psychiatry, Psychology and Neuroscience, King's College London (Seynaeve, Bao, Rucker); independent patient researcher (Bradley-Westguard); National Health Service Foundation Trust (Crawshaw) and Department of Neurology (Edwards), St. George's University Hospitals, London; Institute of Molecular and Clinical Sciences, St. George's University of London (Crawshaw, Edwards); and Sobell Department of Motor Neurosciences and Movement Disorders, Queen Square Institute of Neurology, University College London (Edwards).

Objective: Functional neurological disorder (FND) causes a high burden of disability and distress. Although it is a common disorder, there is a pressing need for improved access to evidence-based treatments. With difficulties in finding effective treatment, some people with FND may seek alternative means of symptom relief, such as legal and illicit psychoactive substances, although the prevalence and nature of such self-management strategies are currently unclear. Read More

Emerg Med Australas 2022 May 15. Epub 2022 May 15.

Emergency Department, St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia.

Objective: To quantify the attitude ED clinicians hold towards patients presenting with different medical conditions, including a novel pandemic condition.

Methods: A cross-sectional study of emergency doctors and nurses utilising the Medical Condition Regard Scale (MCRS); a validated tool used to capture the bias and emotions of clinicians towards individual medical conditions. The five conditions presented to participants each represent a classical medical, complex medical, psychiatric/substance use, somatoform and a novel medical condition. Read More

Psychiatr Pol 2022 Feb 27;56(1):63-75. Epub 2022 Feb 27.

Warszawski Uniwersytet Medyczny, Katedra i Klinika Psychiatryczna.

Ganser syndrome (GS) is one of afew eponyms that have survived in psychiatry until the present day. GS is a little-known and rare disorder. It is most often described as a response to a stressor (e. Read More

Pediatr Res 2022 May 14. Epub 2022 May 14.

Research and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, Dr. Antoni Pujadas, 42, Sant Boi de Llobregat, Barcelona, Spain.

Background: This study aimed to investigate the prevalence of and the factors associated with post-COVID-2019 condition in COVID-19 children and adolescents in Germany.

Methods: The present retrospective cohort study used data from the Disease Analyzer database (IQVIA), and included patients aged <18 years who were diagnosed with COVID-19 in one of 524 general and 81 pediatric practices in Germany between October 2020 and August 2021 (index date: first COVID-19 diagnosis). Post-COVID-19 condition was assessed between the index date and November 2021. Read More

Med J Aust 2022 Jun 14;216(10):501-503. Epub 2022 May 14.

UNSW Sydney, Sydney, NSW.

Front Psychiatry 2022 26;13:791333. Epub 2022 Apr 26.

Clinic for Psychiatry and Psychotherapy I, Ulm University, Ulm, Germany.

Background: Research in recent years has demonstrated that the use of coercive measures such as seclusion and restraint differs very much between hospitals within a country. In 2015, a central register for all coercive measures in the German federal state of Baden-Wuerttemberg has been established for 32 hospitals treating involuntary patients. The objective of the present study was to identify factors that determine the differences between these hospitals. Read More

Lancet Reg Health West Pac 2022 Apr 2;21:100385. Epub 2022 Feb 2.

Royal Flying Doctor Service, Cairns, Australia.

Background: Understanding cultural differences between geographical regions is essential in delivering culturally appropriate healthcare. We aimed to describe the characteristics and outcomes of diverse clients using the Far North Mental Health and Wellbeing Service (FNS) and the Central West Health and Wellbeing Service (CWS).

Methods: We conducted a cohort study within Queensland, Australia, on all clients who received a mental health therapy session at either the FNS or the CWS. Read More

Psychiatry Res 2022 07 2;313:114593. Epub 2022 May 2.

Department of Primary Care and Clinical Medicine, Sam Houston State University, Texas. Electronic address:

Limitations of a polythetic-categorical classification system has sparked ongoing quantitative efforts to establish a valid and reliable method for diagnosing mental illness. Dimensional methods of classification, such as the Hierarchical Taxonomy of Psychopathology (HiTOP), have been found to ameliorate the limitations of a categorical approach - despite the provisional placement of a Somatoform spectrum. The current investigation sought to elucidate the placement of the Somatoform spectrum within the HiTOP model, and to further corroborate discriminant and convergent validity of the Somatoform spectrum. Read More

Psychiatry Res Neuroimaging 2022 07 29;323:111487. Epub 2022 Apr 29.

Fırat University, Faculty of Medicine, Department of Psychiatry, Elazig, Turkey.

Ned Tijdschr Geneeskd 2022 02 24;166. Epub 2022 Feb 24.

GGZ Breburg, Tilburg.

In 2 cases of men aged 26 and 55 respectively we illustrate the complexity of MUS patients since in both cases a somatic diagnosis was missed. The first patient presented with an inability to walk and persistent pain. Because of his symptoms he lost his job, had depressive moods and used alcohol and cannabis. Read More

Front Public Health 2022 12;10:844874. Epub 2022 Apr 12.

Department of Psychosomatic Medicine and Psychotherapy, Paracelsus Medical Private University, Nuremberg General Hospital, Nuremberg, Germany.

Introduction: Specialized biopsychosocial care concepts are necessary to overcome the dualism between physical and psychosocial treatment in acute care hospitals. For patients with complex and chronic comorbid physical and mental health problems, neither standardized psychiatric/psychosomatic nor somatic care units alone are appropriate to their needs. The " uremberg ntegrated sychosomatic cute Unit" (NIPA) has been developed to integrate treatment of both, psychosocial and physical impairments, in an acute somatic care setting. Read More