3,068 results match your criteria Solitary Pulmonary Nodule Imaging


Changes in quantitative parameters of pulmonary nonsolid nodule induced by lung inflation according to paired inspiratory and expiratory computed tomography imaging.

Eur Radiol 2019 Jan 28. Epub 2019 Jan 28.

Department of Radiology, Changzheng Hospital, Second Military Medical University, No. 415 Fengyang Road, Shanghai, 200003, China.

Objective: To evaluate quantitative parameters of nonsolid nodules on paired inspiratory and expiratory computed tomography (CT) and to examine whether these parameters are sensitive to lung inflation reflected by lung volume.

Methods: Thirty-three patients with 41 nonsolid nodules were included in this prospective study. Paired inspiratory and low-dose respiratory plain chest CT were performed. Read More

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http://link.springer.com/10.1007/s00330-018-5970-5
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http://dx.doi.org/10.1007/s00330-018-5970-5DOI Listing
January 2019
9 Reads

Invasive Pulmonary Adenocarcinoma with Lepidic Growth Pattern in a Pregnant Patient.

Case Rep Oncol 2018 Sep-Dec;11(3):822-834. Epub 2018 Dec 11.

University of Groningen, University Medical Center Groningen, Department of Neurology, Groningen, The Netherlands.

Among the differential diagnoses that should be considered in acute respiratory failure (ARF) are infectious processes, autoimmune diseases, interstitial pulmonary fibrosis, and pulmonary neoplasia. Timely diagnosis of lung neoplasia is complicated in the early stages. An opportune diagnosis, as well as the specific treatment, decrease mortality. Read More

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http://dx.doi.org/10.1159/000495460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341323PMC
December 2018
6 Reads

[Treatment principle and surgical technique of pulmonary ground glass nodules].

Zhonghua Zhong Liu Za Zhi 2019 Jan;41(1):6-9

Department of thoracic surgery, Zhongshan hospital, Fudan university, Shanghai 200032, China.

Pulmonary ground glass nodule (GGN) is a term of radiological manifestation, which may be malignant or benign. GGN's imaging performance is diverse, and the management for pulmonary GGN remains controversial. Numerous clinical studies have clarified the safety of GGN follow-up and longer follow-up intervals, stricter surgical or biopsy indications are recommended. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2019.01.002DOI Listing
January 2019

Is 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography useful to discriminate metachronous lung cancer from metastasis in patients with oncological history?

Q J Nucl Med Mol Imaging 2019 Jan 17. Epub 2019 Jan 17.

Nuclear Medicine Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy -

Background: Solitary pulmonary nodules detected during follow-up in patients with previous cancer history have a high probability of malignancy being either a metachronous lung cancer or a metastasis. This distinction represents a crucial issue in the perspective of "personalized medicine", implying different treatments and prognosis. Aim - to evaluate the role of 18F-Fluorodeoxyglucose (18F-FDG) Positron Emission Tomography/Computed Tomography (PET/CT) in distinguishing whether solitary pulmonary nodules are metachronous cancers or metastases and the relationship between the nodule's characteristics and their nature. Read More

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http://dx.doi.org/10.23736/S1824-4785.19.03140-6DOI Listing
January 2019
1 Read

PET Counting Response Variability Depending on Tumor Location, Activity, and Patient Obesity: A Feasibility Study of Solitary Pulmonary Nodule Using Monte Carlo.

IEEE Trans Med Imaging 2019 Jan 10. Epub 2019 Jan 10.

We aim to investigate the counting response variations of Positron Emission Tomography (PET) scanners with different detector configurations in the presence of Solitary Pulmonary Nodule (SPN). Using experimentally validated Monte Carlo simulations, the counting performance of four different scanner models with varying tumor activity, location, and patient obesity is represented using NECR (Noise Equivalent Count Rate). NECR is a well-established quantitative metric which has positive correlation with clinically perceived image quality. Read More

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http://dx.doi.org/10.1109/TMI.2019.2891578DOI Listing
January 2019
1 Read

Primary Pulmonary Chordoid Meningioma.

Korean J Thorac Cardiovasc Surg 2018 Dec 5;51(6):410-414. Epub 2018 Dec 5.

Department of Pathology, Hanyang University Seoul Hospital, Hanyang University College of Medicine.

Primary pulmonary meningioma is a rare disease, and chordoid meningioma is an uncommon variant of meningioma in the central nervous system (CNS) with a high recurrence rate. We report a case of primary pulmonary chordoid meningioma that presented as a solitary pulmonary nodule (SPN). The SPN was resected by thoracoscopic wedge resection and was revealed to have characteristics of chordoid meningioma. Read More

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http://dx.doi.org/10.5090/kjtcs.2018.51.6.410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301318PMC
December 2018
2 Reads

Can spectral computed tomography imaging improve the differentiation between malignant and benign pulmonary lesions manifesting as solitary pure ground glass, mixed ground glass, and solid nodules?

Thorac Cancer 2019 Feb 23;10(2):234-242. Epub 2018 Dec 23.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiology, Peking University Cancer Hospital & Institute, Beijing, China.

Background: This study quantitatively assessed the efficacy of spectral computed tomography (CT) imaging parameters for differentiating the malignancy and benignity of solitary pulmonary nodules (SPNs) manifesting as ground glass nodules (GGNs) and solid nodules (SNs).

Methods: The study included 114 patients with SPNs (61 GGNs, and 53 SNs) who underwent CT plain and enhanced scans in the arterial (a) and venous (v) phases using the spectral imaging mode. The spectral CT imaging parameters included: iodine concentrations (IC) of lesions in the arterial (ICLa) and venous (ICLv) phases; normalized IC (NICa/NICv, normalized to the IC in the aorta); the slope of the spectral Hounsfield unit (HU) curve (λHUa/λHUv); and monochromatic CT number (CT40keVa/v, CT70keVa/v) enhancement on 40 and 70 keV images. Read More

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http://dx.doi.org/10.1111/1759-7714.12937DOI Listing
February 2019
1 Read

Update on radioguided surgery: from international consensus on sentinel node in head and neck cancer to the advances on gynaecological tumors and localization of non-palpable lesions.

Rev Esp Med Nucl Imagen Mol 2018 Dec 19. Epub 2018 Dec 19.

Servicio de Medicina Nuclear, Complejo Hospitalario de Navarra , Pamplona, Navarra, España. Electronic address:

The aim of this review is to provide an updated perspective on different fields of radioguided surgery. With reference to the sentinel lymph node biopsy in oral squamous cell carcinoma, we present the results of the interactive debate held at the recent Congress of our specialty about the more relevant aspects of the London Consensus. Drainage peculiarities and indications according to the current guidelines on gynaecological tumours, endometrial and cervical cancer, are detailed and new scenarios for nuclear medicine physicians are presented; robotic surgery and hybrid tracers, for instance. Read More

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http://dx.doi.org/10.1016/j.remn.2018.10.007DOI Listing
December 2018
1 Read

Erythroderma and a Pulmonary Nodule.

N Engl J Med 2018 Dec;379(24):e41

University Hospital of Parma, Parma, Italy

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http://dx.doi.org/10.1056/NEJMicm1802572DOI Listing
December 2018
1 Read

F-FDG PET/CT diagnostic performance in solitary and multiple pulmonary nodules detected in patients with previous cancer history: reports of 182 nodules.

Eur J Nucl Med Mol Imaging 2019 02 8;46(2):429-436. Epub 2018 Dec 8.

Nuclear Medicine Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Francesco Vito, 1, 00168, Roma, Italia.

Purpose: In oncological patients, F-FDG PET/CT performance for pulmonary nodules' characterization is not well-established. Thus, the purpose of this study was to evaluate the F-FDG PET/CT diagnostic performance in pulmonary nodules detected during follow-up in oncological patients and the relationship between malignancy and nodules' characteristics.

Methods: We retrospectively evaluated 182 pulmonary nodules (121 solitary, 61 multiple; mean size = 16. Read More

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http://dx.doi.org/10.1007/s00259-018-4226-6DOI Listing
February 2019
3 Reads

[Comparative analysis of computed tomography texture features between pulmonary inflammatory nodules and lung cancer].

Zhonghua Zhong Liu Za Zhi 2018 Nov;40(11):847-850

Department of Radiology, Shanxi Dayi Hospital, Taiyuan 030032, China.

To investigate the value of computed tomography (CT) texture analysis in differential diagnosis of inflammatory and malignant pulmonary nodules. The image data of 54 patients with lung cancer and 36 patients with pulmonary inflammatory nodules were retrospectively collected in our hospital. All the patients received chest CT scan. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2018.11.010DOI Listing
November 2018
9 Reads

Incidental Pulmonary Nodules Detected on CT Images.

JAMA 2018 Dec;320(21):2260-2261

University of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1001/jama.2018.16336DOI Listing
December 2018
1 Read

Outcome of untreated lung nodules with histological but no microbiological evidence of tuberculosis.

BMC Infect Dis 2018 Oct 23;18(1):530. Epub 2018 Oct 23.

Division of Thoracic Surgery, Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

Background: The outcome of lung nodule(s) with histopathological findings suggestive of tuberculosis (TB) but lack of microbiologic confirmation remains unclear. Whether these patients require anti-TB treatment remains unknown. The aim of the study was to compare the risk of active TB within 4 years in untreated patients with histological findings but no microbiological evidences suggestive of TB. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3442-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199800PMC
October 2018
7 Reads

Comparison of Various Parameters of DWI in Distinguishing Solitary Pulmonary Nodules.

Curr Med Sci 2018 Oct 20;38(5):920-924. Epub 2018 Oct 20.

Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

In order to prospectively assess various parameters of diffusion weighted imaging (DWI) in differential diagnosis of benign and malignant solitary pulmonary nodules (SPNs), 58 patients (40 men and 18 women, and mean age of 48.1±10.4 years old) with SPNs undergoing conventional MR, DWI using b=500 s/mm on a 1. Read More

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http://link.springer.com/10.1007/s11596-018-1963-5
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http://dx.doi.org/10.1007/s11596-018-1963-5DOI Listing
October 2018
18 Reads

Single-view 2D CNNs with fully automatic non-nodule categorization for false positive reduction in pulmonary nodule detection.

Comput Methods Programs Biomed 2018 Oct 31;165:215-224. Epub 2018 Aug 31.

School of Electrical Engineering, Korea Advanced Institute of Science and Technology, Republic of Korea. Electronic address:

Background And Objective: In pulmonary nodule detection, the first stage, candidate detection, aims to detect suspicious pulmonary nodules. However, detected candidates include many false positives and thus in the following stage, false positive reduction, such false positives are reliably reduced. Note that this task is challenging due to 1) the imbalance between the numbers of nodules and non-nodules and 2) the intra-class diversity of non-nodules. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01692607183074
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http://dx.doi.org/10.1016/j.cmpb.2018.08.012DOI Listing
October 2018
8 Reads

The "solid" component within subsolid nodules: imaging definition, display, and correlation with invasiveness of lung adenocarcinoma, a comparison of CT histograms and subjective evaluation.

Eur Radiol 2018 Oct 15. Epub 2018 Oct 15.

Department of Radiology, Changzheng Hospital, Second Military Medical University, No. 415 Fengyang Road, Shanghai, 200003, China.

Objective: To validate three proposed definitions of the "solid" component of subsolid nodules, as compared to CT histograms and the use of different window settings, for discriminating the invasiveness of adenocarcinomas in a manner that facilitates routine clinical assessment.

Methods: We retrospectively analyzed 328 pathologically confirmed lung adenocarcinomas, manifesting as subsolid nodules. Three-dimensional CT histograms were generated by setting 11 CT attenuation intervals from - 400 to 50 HU, at 50 HU intervals, and the voxel percentage within each CT attenuation interval was generated automatically. Read More

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http://link.springer.com/10.1007/s00330-018-5778-3
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http://dx.doi.org/10.1007/s00330-018-5778-3DOI Listing
October 2018
10 Reads
4.014 Impact Factor

Primary pulmonary meningioma mimicking lung metastatic tumor: a case report.

J Cardiothorac Surg 2018 Oct 1;13(1):99. Epub 2018 Oct 1.

Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.

Background: Primary pulmonary meningioma (PPM) is an extremely rare benign tumor. Previous reports indicated that CT features of PPM are single, solid, well-demarcated, homogeneous mass. In this study, we report a case of PPM with atypical CT features. Read More

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http://dx.doi.org/10.1186/s13019-018-0787-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167906PMC
October 2018
5 Reads

Influence of radiologic expertise in detecting lung tumors on chest radiographs.

Diagn Interv Imaging 2019 Feb 25;100(2):95-107. Epub 2018 Sep 25.

University of Tsukuba, Faculty of Medicine, Department of Diagnostic and Interventional Radiology, Ibaraki, Japan.

Purpose: To analyze the influence of radiologic expertise in detecting lung tumors on chest radiographs.

Materials And Methods: We retrieved posteroanterior chest radiographs and CT examination obtained from 283 patients with solitary primary malignant lung tumors who underwent surgical resection. There were 176 men and 107 women with a mean age of 67. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22115684183022
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http://dx.doi.org/10.1016/j.diii.2018.08.015DOI Listing
February 2019
5 Reads

CT characterization of different pathological types of subcentimeter pulmonary ground-glass nodular lesions.

Br J Radiol 2019 Feb 9;92(1094):20180204. Epub 2018 Oct 9.

1 Department of Radiology, Huadong Hospital affiliated with Fudan University , Shanghai , China.

Objective: To explore the CT characteristics of small lung nodules and improve the diagnosis of pulmonary ground-glass nodules less than 10  mm in size.

Methods: We retrospectively analyzed CT images of 161 pulmonary nodules (less than 10  mm in size) with spiculation, lobulation, vacuoles, and pleural indentation and compared these images with pathological results or follow-up CT images. The relationships between the ground-glass nodules (GGNs) and blood vessels were observed. Read More

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https://www.birpublications.org/doi/10.1259/bjr.20180204
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http://dx.doi.org/10.1259/bjr.20180204DOI Listing
February 2019
2 Reads

Differentiating between malignant and benign solid solitary pulmonary lesions: are intravoxel incoherent motion and diffusion kurtosis imaging superior to conventional diffusion-weighted imaging?

Eur Radiol 2019 Mar 25;29(3):1607-1615. Epub 2018 Sep 25.

Department of Radiology, The First Affiliated Hospital of Guangzhou Medical University, Yanjiangxilu No 151., Guangzhou, China.

Objective: To quantitatively compare the diagnostic values of various diffusion parameters obtained from mono- and biexponential diffusion-weighted imaging (DWI) models and diffusion kurtosis imaging (DKI) in differentiating between benign and malignant solitary pulmonary lesions (SPLs).

Methods: Multiple b-value DWIs and DKIs were performed in 89 patients with SPL by using a 3-T magnetic resonance (MR) imaging unit. The apparent diffusion coefficient (ADC) of various b-value sets, true diffusivity (D), pseudo-diffusion coefficient (D*), perfusion fraction (f), apparent diffusional kurtosis (K), and kurtosis-corrected diffusion coefficient (D) were calculated and compared between the malignant and benign groups using a Mann-Whitney U test. Read More

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http://dx.doi.org/10.1007/s00330-018-5714-6DOI Listing
March 2019
16 Reads

Alpha-fetoprotein (AFP) as tumor marker in a patient with urothelial cancer with exceptional response to anti-PD-1 therapy and an escape lesion mimic.

J Immunother Cancer 2018 Sep 12;6(1):89. Epub 2018 Sep 12.

Division of Hematology and Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA.

The development of a new lesion in a patient with a complete remission to anti-PD-1 therapy is highly concerning for a drug resistant escape lesion. Here, we present a case of a 62-year-old patient with chemotherapy-resistant metastatic urothelial cancer who had a complete remission to pembrolizumab. The patient's disease burden tracked closely to serum levels of alpha-fetoprotein (AFP) expressed by the tumor and served as an accurate tumor marker. Read More

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https://jitc.biomedcentral.com/articles/10.1186/s40425-018-0
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http://dx.doi.org/10.1186/s40425-018-0394-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134551PMC
September 2018
14 Reads

Updated Fleischner Society Guidelines for Managing Incidental Pulmonary Nodules: Common Questions and Challenging Scenarios.

Radiographics 2018 Sep-Oct;38(5):1337-1350

From the Department of Radiology and Medical Imaging, University of Virginia Medical Center, 1215 Lee St, PO Box 800170, Charlottesville, VA 22908 (J.B.); and Department of Radiology, University of Chicago, Chicago, Ill (L.L., J.H.C.).

The new guidelines for managing incidental pulmonary nodules published by the Fleischner Society in 2017 reflect an improved understanding of the risk factors and biologic features of lung cancer. Specific topics emphasized in the updated guidelines include a new threshold size for follow-up, the importance of the morphologic features of nodules, accurate nodule measurements, recognition of subsolid components, understanding interval growth or change in nodule morphology, and knowledge of patient risk factors. The updated guidelines enable greater personal flexibility in the decision-making process and encourage individualized management of pulmonary nodules. Read More

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http://pubs.rsna.org/doi/10.1148/rg.2018180017
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http://dx.doi.org/10.1148/rg.2018180017DOI Listing
December 2018
3 Reads

The plasma glutamate concentration as a complementary tool to differentiate benign PET-positive lung lesions from lung cancer.

BMC Cancer 2018 Sep 3;18(1):868. Epub 2018 Sep 3.

Applied and Analytical Chemistry, Institute for Materials Research, Hasselt University, Agoralaan Building D, B-3590, Diepenbeek, Belgium.

Background: Pulmonary imaging often identifies suspicious abnormalities resulting in supplementary diagnostic procedures. This study aims to investigate whether the metabolic fingerprint of plasma allows to discriminate between patients with lung inflammation and patients with lung cancer.

Methods: Metabolic profiles of plasma from 347 controls, 269 cancer patients and 108 patients with inflammation were obtained by H-NMR spectroscopy. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-018-4755-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122613PMC
September 2018
18 Reads

The value of the air bronchogram sign on CT image in the identification of different solitary pulmonary consolidation lesions.

Medicine (Baltimore) 2018 Aug;97(35):e11985

Shandong Medical Imaging Research Institute Affiliated to Shandong University.

The aim of the present study is to investigate the value of air bronchogram sign on computed tomography (CT) image in the differential diagnosis of solitary pulmonary consolidation lesions (SPLs).A total of 105 patients (including 39 cases of lung cancer, 43 cases of tuberculosis, and 23 cases of pneumonia) with SPLs were evaluated for the CT features of air bronchogram sign in this retrospective study. The shape and lumen of the bronchi with air bronchogram sign, the length of the involved bronchus with air bronchogram sign, the length of lesion on the same plane and direction, and the ratio between the length of the involved bronchus and that of the lesion were evaluated. Read More

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http://dx.doi.org/10.1097/MD.0000000000011985DOI Listing
August 2018
3 Reads
5.723 Impact Factor

Ultralow dose CT for follow-up of solid pulmonary nodules: A pilot single-center study using Bland-Altman analysis.

Medicine (Baltimore) 2018 Aug;97(34):e12019

Department of Radiology.

Solid pulmonary nodules are a common finding requiring serial computed tomography (CT) imaging. We sought to explore the detection and measurement accuracy of an ultralow-dose CT (ULDCT) protocol compared with our standard low-dose CT (LDCT) nodule follow-up protocol.In this pragmatic single-center pilot prospective cohort study, patients scheduled for clinically indicated CT surveillance of 1 or more known solid pulmonary nodules >2 mm underwent ULDCT immediately after routine LDCT. Read More

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http://dx.doi.org/10.1097/MD.0000000000012019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112944PMC
August 2018
9 Reads

Noninvasive pulmonary nodule characterization using transcutaneous bioconductance: Preliminary results of an observational study.

Medicine (Baltimore) 2018 Aug;97(34):e11924

Division of Radiology.

We sought to assess the use of an electro pulmonary nodule (EPN) scanner (FreshMedx, Salt Lake City, UT) in the noninvasive characterization of pulmonary nodules using transcutaneous bioconductance.Monocentric prospective study including patients with a pulmonary nodule identified on a chest computed tomography scan. Study protocol approved by the institutional review board and written consent was obtained for every patient. Read More

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http://Insights.ovid.com/crossref?an=00005792-201808240-0005
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http://dx.doi.org/10.1097/MD.0000000000011924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113006PMC
August 2018
5 Reads

[Minimally invasive resection of nonpalpable pulmonary nodules after wire- and isotope-guided localization].

Orv Hetil 2018 Aug;159(34):1399-1404

Mellkassebészeti Osztály, Országos Onkológiai Intézet Budapest, Ráth Gy. u. 7-9., 1122.

Introduction: Nowadays ever smaller, sub-centimetre lung nodules are screened and diagnosed. For these, minimally invasive resection is strongly recommended both with diagnostic and therapeutic purpose.

Aim: Despite many advantages of minimally invasive thoracic surgery, thorough palpation of the lung lobes and thus the localization of lung nodules are still limited. Read More

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http://dx.doi.org/10.1556/650.2018.31148DOI Listing
August 2018
1 Read

Intraoperative fluorescence imaging in thoracic surgery.

J Surg Oncol 2018 Aug 11;118(2):344-355. Epub 2018 Aug 11.

Department of Surgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania.

Intraoperative fluorescence imaging (IFI) can improve real-time identification of cancer cells during an operation. Phase I clinical trials in thoracic surgery have demonstrated that IFI with second window indocyanine green (TumorGlow ) can identify subcentimeter pulmonary nodules, anterior mediastinal masses, and mesothelioma, while the use of a folate receptor-targeted near-infrared agent, OTL38, can improve the specificity for diagnosing tumors with folate receptor expression. Here, we review the existing preclinical and clinical data on IFI in thoracic surgery. Read More

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http://dx.doi.org/10.1002/jso.25149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146026PMC
August 2018
4 Reads

A novel CT-guided technique using medical adhesive for localization of small pulmonary ground-glass nodules and mixed ground-glass nodules (≤20 mm) before video-assisted thoracoscopic surgery.

Diagn Interv Radiol 2018 Jul;24(4):209-212

Department of Radiology, Beijing Hospital, National Center of Gerontology, Beijing, China.

Purpose: We aimed to evaluate the success rate and complication occurrence of CT-guided localization of small pure ground-glass nodules (pGGNs) and mixed ground-glass nodules (mGGNs) with medical adhesive injection before video-assisted thoracoscopic surgery (VATS).

Methods: From March 2015 to May 2017, 41 patients with 44 small pGGNs and mGGNs underwent CT-guided percutaneous localization with medical adhesive prior to wedge resection by VATS.

Results: Localization with medical adhesive was successful in all patients (100%). Read More

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http://dx.doi.org/10.5152/dir.2018.17315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045517PMC
July 2018
7 Reads

Combination of positron emission tomography/computed tomography and chest thin-layer high-resolution computed tomography for evaluation of pulmonary nodules: Correlation with imaging features, maximum standardized uptake value, and pathology.

Medicine (Baltimore) 2018 Aug;97(31):e11640

Department of Nuclear Medicine, Tianjin Medical University General Hospital.

This study aimed to analyze the imaging findings of F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) and chest thin-layer high-resolution computed tomography (HRCT), correlate the maximum standardized uptake value (SUVmax), and the pathological type of benign or malignant pulmonary nodules (PNs), and assess the diagnostic accuracy in differentiating malignant from benign PNs.A retrospective review of F-FDG PET/CT scans from 88 patients with PNs confirmed by pathology or clinical follow-up were included. They both accepted PET/CT and HRCT scan conventional. Read More

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http://dx.doi.org/10.1097/MD.0000000000011640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081071PMC
August 2018
6 Reads

Observer variability for Lung-RADS categorisation of lung cancer screening CTs: impact on patient management.

Eur Radiol 2019 Feb 31;29(2):924-931. Epub 2018 Jul 31.

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Geert Grooteplein 10, 6525, GA, Nijmegen, the Netherlands.

Objectives: Lung-RADS represents a categorical system published by the American College of Radiology to standardise management in lung cancer screening. The purpose of the study was to quantify how well readers agree in assigning Lung-RADS categories to screening CTs; secondary goals were to assess causes of disagreement and evaluate its impact on patient management.

Methods: For the observer study, 80 baseline and 80 follow-up scans were randomly selected from the NLST trial covering all Lung-RADS categories in an equal distribution. Read More

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http://dx.doi.org/10.1007/s00330-018-5599-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302878PMC
February 2019
6 Reads

Age, comorbidity, life expectancy, and pulmonary nodule follow-up in older veterans.

PLoS One 2018 25;13(7):e0200496. Epub 2018 Jul 25.

Division of Geriatrics, University of California, San Francisco and San Francisco Veterans Affairs Medical Center, San Francisco, CA, United States of America.

Background: Pulmonary nodule guidelines do not indicate how to individualize follow-up according to comorbidity or life expectancy.

Objectives: To characterize comorbidity and life expectancy in older veterans with incidental, symptom-detected, or screen-detected nodules in 2008-09 compared to 2013-14. To determine the impact of these patient factors on four-year nodule follow-up among the 2008-09 subgroup. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200496PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059441PMC
January 2019
1 Read

Atypical CT findings of pulmonary sarcoidosis: A case report.

Medicine (Baltimore) 2018 Jul;97(29):e11456

Department of Rheumatology, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Korea.

Rationale: Pulmonary involvement occurs in about 90% of patients with sarcoidosis. However, delayed diagnosis sometimes occurs due to atypical thoracic imaging findings.

Patient Concerns: A 52-year-old woman presented with recurrent uveitis and fever of unknown origin. Read More

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http://dx.doi.org/10.1097/MD.0000000000011456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086523PMC
July 2018
14 Reads

Diagnosis of human bovine tuberculosis aided by PET/CT scanning and EBUS-TBNA.

BMJ Case Rep 2018 Jul 16;2018. Epub 2018 Jul 16.

Department of Radiology, South Tees Hospitals NHS Foundation Trust, Middlesbrough, UK.

Human bovine tuberculosis is a rare zoonotic infection in developed countries which has been achieved predominantly by effective eradication programmes in cattle. The principal modes of transmission are consumption of unpasteurised dairy products and close contact with infected cattle. The clinical and radiological presentation is indistinguishable from tuberculosis caused by The diagnosis should be considered in individuals with relevant risk factors who present with intra/extrathoracic pathology. Read More

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http://dx.doi.org/10.1136/bcr-2018-225351DOI Listing
July 2018
9 Reads

Is F-FDG PET/CT useful for the differential diagnosis of solitary pulmonary nodules in patients with idiopathic pulmonary fibrosis?

Ann Nucl Med 2018 Aug 4;32(7):492-498. Epub 2018 Jul 4.

Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.

Objective: Idiopathic pulmonary fibrosis (IPF) is associated with an increased incidence of lung cancer, but patients with IPF often have poor pulmonary function and are vulnerable to pneumothorax and so using an invasive procedure to diagnose a single nodule detected on chest CT risks a critical adverse outcome. F-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) is recognized to be useful for differentiating between benign and malignant solitary pulmonary nodules (SPN) in patients without IPF, but its diagnostic accuracy has not been investigated in patients with IPF. In this study, therefore, we investigated whether F-FDG PET/CT is useful for the differential diagnosis of SPNs in patients with IPF. Read More

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http://dx.doi.org/10.1007/s12149-018-1273-9DOI Listing
August 2018
12 Reads
1.507 Impact Factor

Radiomics signature: a biomarker for the preoperative discrimination of lung invasive adenocarcinoma manifesting as a ground-glass nodule.

Eur Radiol 2019 Feb 2;29(2):889-897. Epub 2018 Jul 2.

Department of Radiology, Changzheng Hospital, Second Military Medical University, No. 415 Fengyang Road, Shanghai, 200003, China.

Objectives: To identify the radiomics signature allowing preoperative discrimination of lung invasive adenocarcinomas from non-invasive lesions manifesting as ground-glass nodules.

Methods: This retrospective primary cohort study included 160 pathologically confirmed lung adenocarcinomas. Radiomics features were extracted from preoperative non-contrast CT images to build a radiomics signature. Read More

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http://dx.doi.org/10.1007/s00330-018-5530-zDOI Listing
February 2019
10 Reads

Role of Dual-Energy Computed Tomography in Thoracic Oncology.

Radiol Clin North Am 2018 Jul;56(4):535-548

Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. Electronic address:

Dual-energy CT (DECT) is an emerging technology that has potential to enhance diagnostic performance and radiologists' confidence in the evaluation of thoracic malignancies. DECT clinical applications include characterization of solitary pulmonary nodule, lung masses and mediastinal tumors. DECT-derived iodine uptake quantification may assist in characterization of tumor differentiation and gene expression. Read More

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http://dx.doi.org/10.1016/j.rcl.2018.03.011DOI Listing
July 2018
3 Reads

Combined Hookwire and Methylene Blue Localization of Pulmonary Nodules: Analysis of 74 Patients.

Innovations (Phila) 2018 May/Jun;13(3):184-189

Department of Cardiothoracic Surgery, Tower Health System, Reading, PA USA.

Objective: Because of decreased tactile sensation with thoracoscopic approaches to biopsy, localization preoperatively and intraoperatively is important for successful biopsy. Our study evaluated the technique of combined computed tomography-guided hookwire and methylene blue localization.

Methods: Seventy-five patients from November 2007 to August 2013 who underwent combined Hawkins hookwire and methylene blue localization of 76 total pulmonary nodules before video-assisted thoracic surgery-guided wedge resection were retrospectively reviewed. Read More

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http://dx.doi.org/10.1097/IMI.0000000000000498DOI Listing
December 2018
1 Read

Improved lung nodule diagnosis accuracy using lung CT images with uncertain class.

Comput Methods Programs Biomed 2018 Aug 18;162:197-209. Epub 2018 May 18.

Sino-Dutch Biomedical & Information Engineering School, Northeastern University, China.

Background And Objective: Among all malignant tumors, lung cancer ranks in the top in mortality rate. Pulmonary nodule is the early manifestation of lung cancer, and plays an important role in its discovery, diagnosis and treatment. The technology of medical imaging has encountered a rapid development in recent years, thus the amount of pulmonary nodules can be discovered are on the raise, which means even tiny or minor changes in lung can be recorded by the CT images. Read More

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http://dx.doi.org/10.1016/j.cmpb.2018.05.028DOI Listing
August 2018
20 Reads

Convolutional neural network-based PSO for lung nodule false positive reduction on CT images.

Comput Methods Programs Biomed 2018 Aug 9;162:109-118. Epub 2018 May 9.

Pontifical Catholic University of Rio de Janeiro - PUC - Rio R. São Vicente, 225, Gávea, Rio de Janeiro, RJ 22453-900, Brazil. Electronic address:

Background And Objective: Detection of lung nodules is critical in CAD systems; this is because of their similar contrast with other structures and low density, which result in the generation of numerous false positives (FPs). Therefore, this study proposes a methodology to reduce the FP number using a deep learning technique in conjunction with an evolutionary technique.

Method: The particle swarm optimization (PSO) algorithm was used to optimize the network hyperparameters in the convolutional neural network (CNN) in order to enhance the network performance and eliminate the requirement of manual search. Read More

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http://dx.doi.org/10.1016/j.cmpb.2018.05.006DOI Listing
August 2018
3 Reads

A rare case of human pulmonary dirofilariasis with nodules mimicking malignancy: approach to diagnosis and treatment.

J Cardiothorac Surg 2018 Jun 11;13(1):65. Epub 2018 Jun 11.

Department for the Treatment and Study of Cardiothoracic Diseases and Cardiothoracic Transplantation, IRCCS ISMETT, Via Tricomi 5, Palermo, Italy.

Background: Human pulmonary dirofilariasis is a rare zoonosis caused by the dog worm Dirofilaria spp., a parasite transmitted by mosquitos and resulting in peripheral lung nodules. The filarial nematode enters the subcutaneous tissue, travels to the right ventricle and dies causing a small pulmonary infarction that may embolize through the pulmonary vessels and may appear as a solitary nodule. Read More

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http://dx.doi.org/10.1186/s13019-018-0750-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996523PMC
June 2018
3 Reads
1.020 Impact Factor

[Diagnostic value of endobronchial ultrasonography with guide-sheath combined with virtual bronchoscopy navigation in peripheral lung cancer].

Zhonghua Jie He He Hu Xi Za Zhi 2018 Jun;41(6):473-477

Department of Respiratory Medicine, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.

To explore the diagnostic value and safety of endobronchial ultrasonography with guide-sheath (EBUS-GS) combined with virtual bronchoscopy navigation (VBN) in peripheral lung cancer. Between Dec. 2015 to Dec. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-0939.2018.06.008DOI Listing
June 2018
13 Reads

The utilisation of convolutional neural networks in detecting pulmonary nodules: a review.

Br J Radiol 2018 Oct 19;91(1090):20180028. Epub 2018 Jun 19.

4 Department of Radiology, University of Melbourne , Parkville, VIC , Australia.

Lung cancer is one of the leading causes of cancer-related fatality in the world. Patients display few or even no signs or symptoms in the early stages, resulting in up to 75% of patients diagnosed in the later stages of the disease. Consequently, there has been a call for lung cancer screening amongst at-risk populations. Read More

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http://dx.doi.org/10.1259/bjr.20180028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350496PMC
October 2018
1 Read

Assessing the inter-observer variability of Computer-Aided Nodule Assessment and Risk Yield (CANARY) to characterize lung adenocarcinomas.

PLoS One 2018 1;13(6):e0198118. Epub 2018 Jun 1.

Department of Internal Medicine, Division of Allergy, Pulmonary and Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.

Lung adenocarcinoma (ADC), the most common lung cancer type, is recognized increasingly as a disease spectrum. To guide individualized patient care, a non-invasive means of distinguishing indolent from aggressive ADC subtypes is needed urgently. Computer-Aided Nodule Assessment and Risk Yield (CANARY) is a novel computed tomography (CT) tool that characterizes early ADCs by detecting nine distinct CT voxel classes, representing a spectrum of lepidic to invasive growth, within an ADC. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198118PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983856PMC
December 2018
3 Reads

Small lung nodules detection based on local variance analysis and probabilistic neural network.

Comput Methods Programs Biomed 2018 Jul 28;161:173-180. Epub 2018 Apr 28.

Specialist Hospital Sz. Starkiewicz in Da̧browa Górnicza, Zagłȩbiowskie Oncology Centre, Szpitalna 13, Da̧browa Górnicza 41-300, Poland. Electronic address:

Background And Objective: In medical examinations doctors use various techniques in order to provide to the patients an accurate analysis of their actual state of health. One of the commonly used methodologies is the x-ray screening. This examination very often help to diagnose some diseases of chest organs. Read More

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http://dx.doi.org/10.1016/j.cmpb.2018.04.025DOI Listing
July 2018
3 Reads

The Asymptomatic Dissecting Aortic Aneurysm: An Incidental Finding on CT.

J Coll Physicians Surg Pak 2018 Jun;28(6):482-484

Department of Radiology, Civil Hospital and Dow University of Health Sciences (DUHS), Karachi.

We report a case of 65-year male patient, a known hypertensive and a chronic smoker, who presented to the Civil Hospital, Karachi with complaints of cough, hemoptysis and shortness of breath for three weeks. The chest radiograph showed left apical solitary pulmonary nodule (SPN) and aneurysmal dilatation of the descending thoracic aorta. He was further investigated with contrast enhanced computed tomography (CECT) scan of chest, which apart from demonstrating malignant pulmonary lesion, surprisingly revealed Stanford type B descending thoracic aortic dissecting aneurysm with intramural hematoma, jeopardising renal and splanchnic circulation. Read More

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https://www.jcpsp.pk/data/view.php?id=2933&type=pdf&
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http://dx.doi.org/10.29271/jcpsp.2018.06.482DOI Listing
June 2018
6 Reads

Evolutionary image simplification for lung nodule classification with convolutional neural networks.

Int J Comput Assist Radiol Surg 2018 Oct 29;13(10):1499-1513. Epub 2018 May 29.

Computational Health Informatics, Leibniz University Hanover, Schloßwender Str. 5, 30159, Hanover, Germany.

Purpose: Understanding decisions of deep learning techniques is important. Especially in the medical field, the reasons for a decision in a classification task are as crucial as the pure classification results. In this article, we propose a new approach to compute relevant parts of a medical image. Read More

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http://dx.doi.org/10.1007/s11548-018-1794-7DOI Listing
October 2018

Management of Incidental Lung Nodules.

Authors:
Jane P Ko Lea Azour

Semin Ultrasound CT MR 2018 Jun 26;39(3):249-259. Epub 2018 Mar 26.

Department of Radiology, NYU Langone Health, New York, NY.

The incidental pulmonary nodule is commonly encountered when interpreting chest CTs. The management of pulmonary nodules requires a multidisciplinary approach entailing integration of nodule size and features, clinical risk factors, and patient preference and comorbidities. Guidelines have been issued for the management of both solid and subsolid nodules, with the Fleischner Society issuing revised guidelines in 2017. Read More

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http://dx.doi.org/10.1053/j.sult.2018.02.006DOI Listing

Growth pattern change of a benign clear cell 'sugar' tumor of the lung: Serial imaging surveillance over seven years.

Oncol Lett 2018 Jun 30;15(6):8652-8654. Epub 2018 Mar 30.

Department of Radiology, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul 05278, Republic of Korea.

Clear cell tumor of the lung is a rare benign mesenchymal tumor and only sporadic cases have been previously reported. The present study reports the case of a 58-year-old man who presented with an incidentally detected solitary pulmonary nodule. Based on comparisons with serial previous chest and spine radiographs, a growth pattern change in the nodule (initial gradual growth over 4. Read More

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http://dx.doi.org/10.3892/ol.2018.8391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5950545PMC
June 2018
7 Reads

The Value of F-FDG PET/CT Mathematical Prediction Model in Diagnosis of Solitary Pulmonary Nodules.

Biomed Res Int 2018 28;2018:9453967. Epub 2018 Mar 28.

Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Purpose: To establish an F-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) mathematical prediction model to improve the diagnosis of solitary pulmonary nodules (SPNs).

Materials And Methods: We retrospectively reviewed 177 consecutive patients who underwent F-FDG PET/CT for evaluation of SPNs. The mathematical model was established by logistic regression analysis. Read More

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http://dx.doi.org/10.1155/2018/9453967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896270PMC
October 2018
35 Reads