3,101 results match your criteria Solitary Pulmonary Nodule Imaging


Management of the solitary pulmonary nodule.

Curr Opin Pulm Med 2019 Apr 9. Epub 2019 Apr 9.

Department of Pulmonary Medicine, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Purpose Of Review: We review the categorization and management of solitary pulmonary nodules.

Recent Findings: The National Comprehensive Cancer Network guidelines were updated in 2018 and the revised Fleischner Society guidelines were published in 2017. The revised Fleischner Society guidelines published in 2017 have less frequent follow-up recommendations for incidentally detected pulmonary nodules with longer intervals between subsequent CT scans. Read More

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http://dx.doi.org/10.1097/MCP.0000000000000586DOI Listing
April 2019
3 Reads

Symptomatic pulmonary sclerosing hemangioma: a rare case of a solitary pulmonary nodule in a woman of advanced age.

J Int Med Res 2019 Apr 10:300060519840898. Epub 2019 Apr 10.

1 Department of Respiratory Medicine, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Hubei, China.

Background: Pulmonary sclerosing hemangioma (PSH) is a rare tumor that usually develops in middle-aged Asian women. PSH has four histological types (hemorrhagic, sclerotic, solid, and papillary) and often grows slowly in a lower lobe of the lung. Preoperative misdiagnosis frequently occurs because of the absence of specific clinical manifestations and imaging findings. Read More

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http://dx.doi.org/10.1177/0300060519840898DOI Listing
April 2019
1 Read
1.095 Impact Factor

Evaluation of the solitary pulmonary nodule.

Intern Med J 2019 Mar;49(3):306-315

Department of Respiratory Medicine, Ipswich General Hospital, Brisbane, Queensland, Australia.

The solitary pulmonary nodule represents a common diagnostic challenge for clinicians. While most are benign, a significant number represent early, potentially curable lung cancers. With the increased utilisation of chest computed tomography, solitary pulmonary nodules are increasingly being identified and with lung cancer screening programmes now on the horizon globally, it is crucial clinicians are familiar with the evaluation and management of solitary pulmonary nodules. Read More

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http://dx.doi.org/10.1111/imj.14219DOI Listing
March 2019
3 Reads

Correlation study between dual source CT perfusion imaging and the microvascular composition of solitary pulmonary nodules.

Lung Cancer 2019 Apr 16;130:115-120. Epub 2019 Feb 16.

Department of Radiology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou Province, China. Electronic address:

Objective: To explore the correlation between dual source computed tomography perfusion imaging (CTPI) and microvascular parameters, and evaluate the value of CTPI in the differential diagnosis of solitary pulmonary nodule (SPN).

Methods: 65 consecutive patients with SPN who successfully underwent pre-operative CT perfusion imaging with dual source CT and received a final diagnosis by postoperative pathology. The cases were divided into malignant, benign and inflammatory groups according to the pathological results. Read More

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http://dx.doi.org/10.1016/j.lungcan.2019.02.013DOI Listing
April 2019
1 Read

The value of 18F-FDG PET/CT in the diagnosis of different size of solitary pulmonary nodules.

Medicine (Baltimore) 2019 Mar;98(11):e14813

The First Affiliated Hospital of Soochow University, Suzhou.

This study aimed to evaluate the diagnostic value of F-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) for solitary pulmonary nodules (SPNs) with different diameters.One hundred eighty two consecutive patients with SPN who underwent F-FDG PET/CT examination were retrospectively studied. Patients were categorized into 3 groups according to the diameter of nodules: Group A with the diameter of greater than or equal to 6 mm and less than or equal to 10 mm; Group B with diameter greater than 10 mm and less than or equal to 20 mm; Group C with diameter greater than 20 mm and less than or equal to 30 mm. Read More

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http://dx.doi.org/10.1097/MD.0000000000014813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426628PMC
March 2019
1 Read

Safety and efficacy of computed tomography-guided dye localization using patent blue V for single lung nodule for video-assisted thoracoscopic surgery: a retrospective study.

Ann Transl Med 2019 Jan;7(2):28

Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, Taichung, Taiwan.

Background: For invisible or impalpable lung nodules, video-assisted thoracoscopic surgery (VATS) has some limitations; some preoperative localization has been developed to overcome this limitation. This study aimed to assess the safety and efficacy of preoperative computed tomography (CT)-guided localization with patent blue V dye.

Methods: In this retrospective study, we examined patients with solitary pulmonary nodule undergoing preoperative CT-guided patent blue V dye localization from 2013 to 2015. Read More

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http://dx.doi.org/10.21037/atm.2019.01.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381270PMC
January 2019
2 Reads

[Health economics analysis for 18F-fluorodeoxyglucose positron-emission tomography compared with computed tomography in lung cancer].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2019 Feb;44(2):216-221

PET-CT Center, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Compared with conventional imaging, 18F-fluorodeoxyglucose positron-emission tomography compared with computed tomography (18F-FDG PET/CT) possesses higher sensitivity and specificity in the diagnosis of solitary pulmonary nodule (SPN) and lung cancer. From the perspective of health economics, PET/CT is more suitable strategy for diagnose of SPN with intermediate probability of malignancy, and has good health economics value in preoperative staging diagnosis and follow-up after radiotherapy and chemotherapy of lung cancer. The evaluation method, effect index and comparison method used in the health economics research of PET/CT for lung cancer diagnosis and treatment are cost-effect analysis, life year and incremental cost-effect ratio, respectively. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2019.02.015DOI Listing
February 2019
2 Reads

Lung nodules are reliably detectable on ultra-low-dose CT utilising model-based iterative reconstruction with radiation equivalent to plain radiography.

Clin Radiol 2019 May 1;74(5):409.e17-409.e22. Epub 2019 Mar 1.

General Medicine, Monash Health, Clayton, Victoria, Australia; Monash Imaging, Monash Health, Clayton, Victoria, Australia.

Aim: To determine if ultra-low-dose (ULD) computed tomography (CT) utilising model-based iterative reconstruction (MBIR) with radiation equivalent to plain radiography allows the detection of lung nodules.

Materials And Methods: Ninety-nine individuals undergoing surveillance of solid pulmonary nodules undertook a low-dose (LD) and ULD CT during the same sitting. Image pairs were read blinded, in random order, and independently by two experienced thoracic radiologists. Read More

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http://dx.doi.org/10.1016/j.crad.2019.02.001DOI Listing
May 2019
1 Read

Solitary Nodular Invasive Mucinous Adenocarcinoma of the Lung: Imaging Diagnosis Using the Morphologic-Metabolic Dissociation Sign.

Korean J Radiol 2019 Mar;20(3):513-521

Department of Radiology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea.

Objective: To evaluate the efficacy of the morphologic-metabolic (M-M) dissociation sign based on computed tomography (CT) and fluorine-18-fluorodeoxyglucose positron emission tomography (PET)/CT in discriminating invasive mucinous adenocarcinoma (IMA) from invasive non-mucinous adenocarcinomas (ADCs) of the lung.

Materials And Methods: The Institutional Review Board approved this retrospective study. Among surgically resected solitary pulmonary nodule (SPN)-type ADCs (< 3 cm in diameter), 35 patients with IMAs and 329 with invasive non-mucinous ADCs were included. Read More

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http://dx.doi.org/10.3348/kjr.2018.0409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389819PMC

Usefulness of virtual bronchoscopic navigation combined with endobronchial ultrasound guided transbronchial lung biopsy for solitary pulmonary nodules.

Medicine (Baltimore) 2019 Feb;98(7):e14248

Department of Respiratory Medicine, Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

Background: The aim of this study was to evaluate the diagnostic utility of virtual bronchoscopic navigation (VBN) combined with endobronchial ultrasound (EBUS) guided transbronchial lung biopsy for solitary pulmonary nodules (SPN).

Methods: A total of 115 patients with suspected SPN who underwent transbronchial lung biopsy were evaluated. The patients were randomly divided into an EBUS (EBUS) group and a virtual bronchoscopic navigation combined with endobronchial ultrasound (VBN+EBUS) group. Read More

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http://dx.doi.org/10.1097/MD.0000000000014248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408138PMC
February 2019
1 Read

Changes in quantitative parameters of pulmonary nonsolid nodule induced by lung inflation according to paired inspiratory and expiratory computed tomography imaging.

Eur Radiol 2019 Jan 28. Epub 2019 Jan 28.

Department of Radiology, Changzheng Hospital, Second Military Medical University, No. 415 Fengyang Road, Shanghai, 200003, China.

Objective: To evaluate quantitative parameters of nonsolid nodules on paired inspiratory and expiratory computed tomography (CT) and to examine whether these parameters are sensitive to lung inflation reflected by lung volume.

Methods: Thirty-three patients with 41 nonsolid nodules were included in this prospective study. Paired inspiratory and low-dose respiratory plain chest CT were performed. Read More

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http://link.springer.com/10.1007/s00330-018-5970-5
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http://dx.doi.org/10.1007/s00330-018-5970-5DOI Listing
January 2019
19 Reads

Invasive Pulmonary Adenocarcinoma with Lepidic Growth Pattern in a Pregnant Patient.

Case Rep Oncol 2018 Sep-Dec;11(3):822-834. Epub 2018 Dec 11.

University of Groningen, University Medical Center Groningen, Department of Neurology, Groningen, The Netherlands.

Among the differential diagnoses that should be considered in acute respiratory failure (ARF) are infectious processes, autoimmune diseases, interstitial pulmonary fibrosis, and pulmonary neoplasia. Timely diagnosis of lung neoplasia is complicated in the early stages. An opportune diagnosis, as well as the specific treatment, decrease mortality. Read More

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http://dx.doi.org/10.1159/000495460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341323PMC
December 2018
14 Reads

[Treatment principle and surgical technique of pulmonary ground glass nodules].

Zhonghua Zhong Liu Za Zhi 2019 Jan;41(1):6-9

Department of thoracic surgery, Zhongshan hospital, Fudan university, Shanghai 200032, China.

Pulmonary ground glass nodule (GGN) is a term of radiological manifestation, which may be malignant or benign. GGN's imaging performance is diverse, and the management for pulmonary GGN remains controversial. Numerous clinical studies have clarified the safety of GGN follow-up and longer follow-up intervals, stricter surgical or biopsy indications are recommended. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2019.01.002DOI Listing
January 2019
1 Read

[Combination of CT mulitplane 3D reconstruction, radial endobronchial ultrasound and rapid on-site evaluation for diagnosing peripheral solitary pulmonary nodules].

Zhonghua Yi Xue Za Zhi 2019 Jan;99(2):93-98

Department of Respiratory Medicine, General Hospital of Eastern Theater Command, the Institute of Respiratory Diseases of Nanjing University, Nanjing 210002, China.

To evaluate the diagnostic efficiency of combination of CT multiplane 3D reconstruction (CT-3DR), radial endobronchial ultrasound (R-EBUS), and rapid on-site evaluation (ROSE) for peripheral solitary pulmonary nodules (SPN). A total of 176 patients with peripheral solitary pulmonary nodule were included from the Nanjing Chest Hospital from March 2016 to March 2017. According to different methods, all the patients were divided into four groups: EG (i. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.02.004DOI Listing
January 2019
10 Reads

Is 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography useful to discriminate metachronous lung cancer from metastasis in patients with oncological history?

Q J Nucl Med Mol Imaging 2019 Jan 17. Epub 2019 Jan 17.

Nuclear Medicine Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy -

Background: Solitary pulmonary nodules detected during follow-up in patients with previous cancer history have a high probability of malignancy being either a metachronous lung cancer or a metastasis. This distinction represents a crucial issue in the perspective of "personalized medicine", implying different treatments and prognosis. Aim - to evaluate the role of 18F-Fluorodeoxyglucose (18F-FDG) Positron Emission Tomography/Computed Tomography (PET/CT) in distinguishing whether solitary pulmonary nodules are metachronous cancers or metastases and the relationship between the nodule's characteristics and their nature. Read More

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http://dx.doi.org/10.23736/S1824-4785.19.03140-6DOI Listing
January 2019
2 Reads

PET Counting Response Variability Depending on Tumor Location, Activity, and Patient Obesity: A Feasibility Study of Solitary Pulmonary Nodule Using Monte Carlo.

IEEE Trans Med Imaging 2019 Jan 10. Epub 2019 Jan 10.

We aim to investigate the counting response variations of Positron Emission Tomography (PET) scanners with different detector configurations in the presence of Solitary Pulmonary Nodule (SPN). Using experimentally validated Monte Carlo simulations, the counting performance of four different scanner models with varying tumor activity, location, and patient obesity is represented using NECR (Noise Equivalent Count Rate). NECR is a well-established quantitative metric which has positive correlation with clinically perceived image quality. Read More

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http://dx.doi.org/10.1109/TMI.2019.2891578DOI Listing
January 2019
9 Reads

Clinical application of planar puncture template-assisted computed tomography-guided percutaneous biopsy for small pulmonary nodules.

J Cancer Res Ther 2018 ;14(7):1632-1637

Department of Radiation Oncology, Peking University Third Hospital, Beijing; China Northern Radioactive Brachytherapy Group, Tangshan People's Hospital, Tangshan, Hebei, China.

Aims: The aims of this study were to evaluate the clinical application of planar puncture template (PPT) in computed tomography (CT)-guided percutaneous needle lung biopsy.

Subjects And Methods: A total of 56 patients with small pulmonary nodules who received CT-guided percutaneous lung biopsy assisted by PPT were included in the study. Five steps were included in the study: fixing position, CT scanning and designing needle pathway, installing navigation system and template, puncturing fixation needle, and performing biopsy needle insertion and biopsy. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_1017_17DOI Listing
February 2019
3 Reads

Application value of coaxial biopsy system in needle cutting biopsy for focal ground glass-like density nodule.

J Cancer Res Ther 2018 ;14(7):1509-1514

Department of Radiology, The Affiliated Hospital of Qingdao University, 266101, Shandong, China.

Objective: The objective of the study is to evaluate the clinical efficacy and accuracy of coaxial biopsy puncture applied to make a diagnosis in 76 patients diagnosed with focal ground-glass density nodule (GGN).

Materials And Methods: In total, 76 patients were diagnosed with pure GGN (pGGN), 24 males and 52 females, aged (52 ± 1.2) years on average (range: 47-72 years). Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_382_18DOI Listing
February 2019
2 Reads

Primary Pulmonary Chordoid Meningioma.

Korean J Thorac Cardiovasc Surg 2018 Dec 5;51(6):410-414. Epub 2018 Dec 5.

Department of Pathology, Hanyang University Seoul Hospital, Hanyang University College of Medicine.

Primary pulmonary meningioma is a rare disease, and chordoid meningioma is an uncommon variant of meningioma in the central nervous system (CNS) with a high recurrence rate. We report a case of primary pulmonary chordoid meningioma that presented as a solitary pulmonary nodule (SPN). The SPN was resected by thoracoscopic wedge resection and was revealed to have characteristics of chordoid meningioma. Read More

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http://dx.doi.org/10.5090/kjtcs.2018.51.6.410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301318PMC
December 2018
4 Reads

Can spectral computed tomography imaging improve the differentiation between malignant and benign pulmonary lesions manifesting as solitary pure ground glass, mixed ground glass, and solid nodules?

Thorac Cancer 2019 Feb 23;10(2):234-242. Epub 2018 Dec 23.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiology, Peking University Cancer Hospital & Institute, Beijing, China.

Background: This study quantitatively assessed the efficacy of spectral computed tomography (CT) imaging parameters for differentiating the malignancy and benignity of solitary pulmonary nodules (SPNs) manifesting as ground glass nodules (GGNs) and solid nodules (SNs).

Methods: The study included 114 patients with SPNs (61 GGNs, and 53 SNs) who underwent CT plain and enhanced scans in the arterial (a) and venous (v) phases using the spectral imaging mode. The spectral CT imaging parameters included: iodine concentrations (IC) of lesions in the arterial (ICLa) and venous (ICLv) phases; normalized IC (NICa/NICv, normalized to the IC in the aorta); the slope of the spectral Hounsfield unit (HU) curve (λHUa/λHUv); and monochromatic CT number (CT40keVa/v, CT70keVa/v) enhancement on 40 and 70 keV images. Read More

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http://dx.doi.org/10.1111/1759-7714.12937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360238PMC
February 2019
2 Reads

Update on radioguided surgery: from international consensus on sentinel node in head and neck cancer to the advances on gynaecological tumors and localization of non-palpable lesions.

Rev Esp Med Nucl Imagen Mol 2018 Dec 19. Epub 2018 Dec 19.

Servicio de Medicina Nuclear, Complejo Hospitalario de Navarra , Pamplona, Navarra, España. Electronic address:

The aim of this review is to provide an updated perspective on different fields of radioguided surgery. With reference to the sentinel lymph node biopsy in oral squamous cell carcinoma, we present the results of the interactive debate held at the recent Congress of our specialty about the more relevant aspects of the London Consensus. Drainage peculiarities and indications according to the current guidelines on gynaecological tumours, endometrial and cervical cancer, are detailed and new scenarios for nuclear medicine physicians are presented; robotic surgery and hybrid tracers, for instance. Read More

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http://dx.doi.org/10.1016/j.remn.2018.10.007DOI Listing
December 2018
2 Reads

Erythroderma and a Pulmonary Nodule.

N Engl J Med 2018 Dec;379(24):e41

University Hospital of Parma, Parma, Italy

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http://dx.doi.org/10.1056/NEJMicm1802572DOI Listing
December 2018
2 Reads

Cyst-related primary lung malignancies: an important and relatively unknown imaging appearance of (early) lung cancer.

Eur Respir Rev 2018 Dec 19;27(150). Epub 2018 Dec 19.

Dept of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.

It is well known that lung cancer can manifest itself in imaging as solid and subsolid nodules or masses. However, in this era of increased computed tomography use another morphological computed tomography appearance of lung cancer is increasingly being recognised, presenting as a malignancy in relation to cystic airspaces. Despite the fact that it seems to be a relatively common finding in daily practice, literature on this entity is scarce and presumably the overall awareness is limited. Read More

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http://dx.doi.org/10.1183/16000617.0079-2018DOI Listing
December 2018
1 Read

F-FDG PET/CT diagnostic performance in solitary and multiple pulmonary nodules detected in patients with previous cancer history: reports of 182 nodules.

Eur J Nucl Med Mol Imaging 2019 02 8;46(2):429-436. Epub 2018 Dec 8.

Nuclear Medicine Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Francesco Vito, 1, 00168, Roma, Italia.

Purpose: In oncological patients, F-FDG PET/CT performance for pulmonary nodules' characterization is not well-established. Thus, the purpose of this study was to evaluate the F-FDG PET/CT diagnostic performance in pulmonary nodules detected during follow-up in oncological patients and the relationship between malignancy and nodules' characteristics.

Methods: We retrospectively evaluated 182 pulmonary nodules (121 solitary, 61 multiple; mean size = 16. Read More

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http://dx.doi.org/10.1007/s00259-018-4226-6DOI Listing
February 2019
5 Reads

[Comparative analysis of computed tomography texture features between pulmonary inflammatory nodules and lung cancer].

Zhonghua Zhong Liu Za Zhi 2018 Nov;40(11):847-850

Department of Radiology, Shanxi Dayi Hospital, Taiyuan 030032, China.

To investigate the value of computed tomography (CT) texture analysis in differential diagnosis of inflammatory and malignant pulmonary nodules. The image data of 54 patients with lung cancer and 36 patients with pulmonary inflammatory nodules were retrospectively collected in our hospital. All the patients received chest CT scan. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2018.11.010DOI Listing
November 2018
16 Reads

Incidental Pulmonary Nodules Detected on CT Images.

JAMA 2018 Dec;320(21):2260-2261

University of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1001/jama.2018.16336DOI Listing
December 2018
2 Reads

Cascaded classifiers and stacking methods for classification of pulmonary nodule characteristics.

Authors:
Aydin Kaya

Comput Methods Programs Biomed 2018 Nov 3;166:77-89. Epub 2018 Oct 3.

Hacettepe University, Computer Engineering Department, 06800 Ankara, Turkey. Electronic address:

Background And Objectives: Detection and classification of pulmonary nodules are critical tasks in medical image analysis. The Lung Image Database Consortium (LIDC) database is a widely used resource for small pulmonary nodule classification research. This dataset is comprised of nodule characteristic evaluations and CT scans of patients. Read More

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http://dx.doi.org/10.1016/j.cmpb.2018.10.009DOI Listing
November 2018
2 Reads

Outcome of untreated lung nodules with histological but no microbiological evidence of tuberculosis.

BMC Infect Dis 2018 Oct 23;18(1):530. Epub 2018 Oct 23.

Division of Thoracic Surgery, Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

Background: The outcome of lung nodule(s) with histopathological findings suggestive of tuberculosis (TB) but lack of microbiologic confirmation remains unclear. Whether these patients require anti-TB treatment remains unknown. The aim of the study was to compare the risk of active TB within 4 years in untreated patients with histological findings but no microbiological evidences suggestive of TB. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3442-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199800PMC
October 2018
8 Reads

Comparison of Various Parameters of DWI in Distinguishing Solitary Pulmonary Nodules.

Curr Med Sci 2018 Oct 20;38(5):920-924. Epub 2018 Oct 20.

Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

In order to prospectively assess various parameters of diffusion weighted imaging (DWI) in differential diagnosis of benign and malignant solitary pulmonary nodules (SPNs), 58 patients (40 men and 18 women, and mean age of 48.1±10.4 years old) with SPNs undergoing conventional MR, DWI using b=500 s/mm on a 1. Read More

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http://link.springer.com/10.1007/s11596-018-1963-5
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http://dx.doi.org/10.1007/s11596-018-1963-5DOI Listing
October 2018
28 Reads

Single-view 2D CNNs with fully automatic non-nodule categorization for false positive reduction in pulmonary nodule detection.

Comput Methods Programs Biomed 2018 Oct 31;165:215-224. Epub 2018 Aug 31.

School of Electrical Engineering, Korea Advanced Institute of Science and Technology, Republic of Korea. Electronic address:

Background And Objective: In pulmonary nodule detection, the first stage, candidate detection, aims to detect suspicious pulmonary nodules. However, detected candidates include many false positives and thus in the following stage, false positive reduction, such false positives are reliably reduced. Note that this task is challenging due to 1) the imbalance between the numbers of nodules and non-nodules and 2) the intra-class diversity of non-nodules. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01692607183074
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http://dx.doi.org/10.1016/j.cmpb.2018.08.012DOI Listing
October 2018
10 Reads

High versus low attenuation thresholds to determine the solid component of ground-glass opacity nodules.

PLoS One 2018 18;13(10):e0205490. Epub 2018 Oct 18.

Department of Radiology and the Research Institute of Radiological Science, Gangnam Severance Hospital, Yonsei University college of Medicine, Seoul, Republic of Korea.

Objectives: To evaluate and compare the diagnostic accuracy of high versus low attenuation thresholds for determining the solid component of ground-glass opacity nodules (GGNs) for the differential diagnosis of adenocarcinoma in situ (AIS) from minimally invasive adenocarcinoma (MIA) and invasive adenocarcinoma (IA).

Methods: Eighty-six pathologically confirmed GGNs < 3 cm observed in 86 patients (27 male, 59 female; mean age, 59.3 ± 11. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205490PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193644PMC
March 2019
1 Read

The "solid" component within subsolid nodules: imaging definition, display, and correlation with invasiveness of lung adenocarcinoma, a comparison of CT histograms and subjective evaluation.

Eur Radiol 2019 Apr 15;29(4):1703-1713. Epub 2018 Oct 15.

Department of Radiology, Changzheng Hospital, Second Military Medical University, No. 415 Fengyang Road, Shanghai, 200003, China.

Objective: To validate three proposed definitions of the "solid" component of subsolid nodules, as compared to CT histograms and the use of different window settings, for discriminating the invasiveness of adenocarcinomas in a manner that facilitates routine clinical assessment.

Methods: We retrospectively analyzed 328 pathologically confirmed lung adenocarcinomas, manifesting as subsolid nodules. Three-dimensional CT histograms were generated by setting 11 CT attenuation intervals from - 400 to 50 HU, at 50 HU intervals, and the voxel percentage within each CT attenuation interval was generated automatically. Read More

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http://link.springer.com/10.1007/s00330-018-5778-3
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http://dx.doi.org/10.1007/s00330-018-5778-3DOI Listing
April 2019
18 Reads
4.014 Impact Factor

A Comparison between Prethoracoscopy Localization of Small Pulmonary Nodules by Means of Medical Adhesive versus Hookwire.

J Vasc Interv Radiol 2018 11 5;29(11):1547-1552. Epub 2018 Oct 5.

Department of Pathology, Shaoxing Hospital, Zhejiang University School of Medicine (Shaoxing People's Hospital) No. 568 Zhongxing North Road, Shaoxing, Zhejiang, People's Republic of China, 312000.

Purpose: To compare prethoracoscopy localization of small pulmonary nodules (SPNs) by means of medical adhesive versus hookwire.

Materials And Methods: One hundred seven patients who underwent video-assisted thoracoscopic surgery resection for SPNs were consecutively recruited in this retrospective cohort study. Patients were divided into 2 groups according to the material used for localization of the SPNs: the medical adhesive group (n = 88) and the hookwire group (n = 19). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10510443183121
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http://dx.doi.org/10.1016/j.jvir.2018.05.013DOI Listing
November 2018
17 Reads

Primary pulmonary meningioma mimicking lung metastatic tumor: a case report.

J Cardiothorac Surg 2018 Oct 1;13(1):99. Epub 2018 Oct 1.

Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.

Background: Primary pulmonary meningioma (PPM) is an extremely rare benign tumor. Previous reports indicated that CT features of PPM are single, solid, well-demarcated, homogeneous mass. In this study, we report a case of PPM with atypical CT features. Read More

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http://dx.doi.org/10.1186/s13019-018-0787-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167906PMC
October 2018
7 Reads

Influence of radiologic expertise in detecting lung tumors on chest radiographs.

Diagn Interv Imaging 2019 Feb 25;100(2):95-107. Epub 2018 Sep 25.

University of Tsukuba, Faculty of Medicine, Department of Diagnostic and Interventional Radiology, Ibaraki, Japan.

Purpose: To analyze the influence of radiologic expertise in detecting lung tumors on chest radiographs.

Materials And Methods: We retrieved posteroanterior chest radiographs and CT examination obtained from 283 patients with solitary primary malignant lung tumors who underwent surgical resection. There were 176 men and 107 women with a mean age of 67. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22115684183022
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http://dx.doi.org/10.1016/j.diii.2018.08.015DOI Listing
February 2019
7 Reads

CT characterization of different pathological types of subcentimeter pulmonary ground-glass nodular lesions.

Br J Radiol 2019 Feb 9;92(1094):20180204. Epub 2018 Oct 9.

1 Department of Radiology, Huadong Hospital affiliated with Fudan University , Shanghai , China.

Objective: To explore the CT characteristics of small lung nodules and improve the diagnosis of pulmonary ground-glass nodules less than 10  mm in size.

Methods: We retrospectively analyzed CT images of 161 pulmonary nodules (less than 10  mm in size) with spiculation, lobulation, vacuoles, and pleural indentation and compared these images with pathological results or follow-up CT images. The relationships between the ground-glass nodules (GGNs) and blood vessels were observed. Read More

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https://www.birpublications.org/doi/10.1259/bjr.20180204
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http://dx.doi.org/10.1259/bjr.20180204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404830PMC
February 2019
3 Reads

Differentiating between malignant and benign solid solitary pulmonary lesions: are intravoxel incoherent motion and diffusion kurtosis imaging superior to conventional diffusion-weighted imaging?

Eur Radiol 2019 Mar 25;29(3):1607-1615. Epub 2018 Sep 25.

Department of Radiology, The First Affiliated Hospital of Guangzhou Medical University, Yanjiangxilu No 151., Guangzhou, China.

Objective: To quantitatively compare the diagnostic values of various diffusion parameters obtained from mono- and biexponential diffusion-weighted imaging (DWI) models and diffusion kurtosis imaging (DKI) in differentiating between benign and malignant solitary pulmonary lesions (SPLs).

Methods: Multiple b-value DWIs and DKIs were performed in 89 patients with SPL by using a 3-T magnetic resonance (MR) imaging unit. The apparent diffusion coefficient (ADC) of various b-value sets, true diffusivity (D), pseudo-diffusion coefficient (D*), perfusion fraction (f), apparent diffusional kurtosis (K), and kurtosis-corrected diffusion coefficient (D) were calculated and compared between the malignant and benign groups using a Mann-Whitney U test. Read More

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http://dx.doi.org/10.1007/s00330-018-5714-6DOI Listing
March 2019
20 Reads

The Added Value of Computer-aided Detection of Small Pulmonary Nodules and Missed Lung Cancers.

J Thorac Imaging 2018 Nov;33(6):390-395

Department of Radiology, Mount Sinai School of Medicine, New York, NY.

Lung cancer at its earliest stage is typically manifested on computed tomography as a pulmonary nodule, which could be detected by low-dose multidetector computed tomography technology and the use of thinner collimation. Within the last 2 decades, computer-aided detection (CAD) of pulmonary nodules has been developed to meet the increasing demand for lung cancer screening computed tomography with a larger set of images per scan. This review introduced the basic techniques and then summarized the up-to-date applications of CAD systems in clinical and research programs and in the low-dose lung cancer screening trials, especially in the detection of small pulmonary nodules and missed lung cancers. Read More

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http://dx.doi.org/10.1097/RTI.0000000000000362DOI Listing
November 2018
3 Reads

Alpha-fetoprotein (AFP) as tumor marker in a patient with urothelial cancer with exceptional response to anti-PD-1 therapy and an escape lesion mimic.

J Immunother Cancer 2018 Sep 12;6(1):89. Epub 2018 Sep 12.

Division of Hematology and Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA.

The development of a new lesion in a patient with a complete remission to anti-PD-1 therapy is highly concerning for a drug resistant escape lesion. Here, we present a case of a 62-year-old patient with chemotherapy-resistant metastatic urothelial cancer who had a complete remission to pembrolizumab. The patient's disease burden tracked closely to serum levels of alpha-fetoprotein (AFP) expressed by the tumor and served as an accurate tumor marker. Read More

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https://jitc.biomedcentral.com/articles/10.1186/s40425-018-0
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http://dx.doi.org/10.1186/s40425-018-0394-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134551PMC
September 2018
16 Reads

Updated Fleischner Society Guidelines for Managing Incidental Pulmonary Nodules: Common Questions and Challenging Scenarios.

Radiographics 2018 Sep-Oct;38(5):1337-1350

From the Department of Radiology and Medical Imaging, University of Virginia Medical Center, 1215 Lee St, PO Box 800170, Charlottesville, VA 22908 (J.B.); and Department of Radiology, University of Chicago, Chicago, Ill (L.L., J.H.C.).

The new guidelines for managing incidental pulmonary nodules published by the Fleischner Society in 2017 reflect an improved understanding of the risk factors and biologic features of lung cancer. Specific topics emphasized in the updated guidelines include a new threshold size for follow-up, the importance of the morphologic features of nodules, accurate nodule measurements, recognition of subsolid components, understanding interval growth or change in nodule morphology, and knowledge of patient risk factors. The updated guidelines enable greater personal flexibility in the decision-making process and encourage individualized management of pulmonary nodules. Read More

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http://pubs.rsna.org/doi/10.1148/rg.2018180017
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http://dx.doi.org/10.1148/rg.2018180017DOI Listing
December 2018
10 Reads

Peripheral Lung Nodule Diagnosis and Fiducial Marker Placement Using a Novel Tip-Tracked Electromagnetic Navigation Bronchoscopy System.

J Bronchology Interv Pulmonol 2019 Jan;26(1):41-48

Division of Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill, NC.

Background: Electromagnetic navigation (EMN) has improved bronchoscopic access to peripheral pulmonary nodules. A novel EMN system utilizing novel tip-tracked instruments for endobronchial [electromagnetic navigation bronchoscopy (ENB)] as well as transthoracic lung biopsy [electromagnetic-guided transthoracic needle aspiration (EMTTNA)] has become available. The system provides real-time feedback as well as the ability to biopsy lesions outside of the airway. Read More

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http://dx.doi.org/10.1097/LBR.0000000000000528DOI Listing
January 2019
19 Reads

The plasma glutamate concentration as a complementary tool to differentiate benign PET-positive lung lesions from lung cancer.

BMC Cancer 2018 Sep 3;18(1):868. Epub 2018 Sep 3.

Applied and Analytical Chemistry, Institute for Materials Research, Hasselt University, Agoralaan Building D, B-3590, Diepenbeek, Belgium.

Background: Pulmonary imaging often identifies suspicious abnormalities resulting in supplementary diagnostic procedures. This study aims to investigate whether the metabolic fingerprint of plasma allows to discriminate between patients with lung inflammation and patients with lung cancer.

Methods: Metabolic profiles of plasma from 347 controls, 269 cancer patients and 108 patients with inflammation were obtained by H-NMR spectroscopy. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-018-4755-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122613PMC
September 2018
23 Reads

Video-Assisted Thoracic Surgery Resection without Intraoperative Fluoroscopy after CT-Guided Microcoil Localization of Peripheral Pulmonary Nodules.

J Vasc Interv Radiol 2018 10 31;29(10):1423-1428. Epub 2018 Aug 31.

Department of Thoracic Surgery, Cleveland Clinic, 9500 Euclid Ave., L10, Cleveland, OH 44195.

The aim of this brief report is to determine the safety and reliability of minimally invasive video-assisted thoracic surgery (VATS) resection without the aid of intraoperative fluoroscopy after computed tomography (CT)-guided microcoil localization of small peripheral pulmonary nodules. Twenty patients with peripheral lung nodules underwent percutaneous needle localization with a microcoil that was tagged back to the visceral pleural surface. Same-day VATS resection was performed without the use of intraoperative fluoroscopy. Read More

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http://dx.doi.org/10.1016/j.jvir.2018.01.787DOI Listing
October 2018

The value of the air bronchogram sign on CT image in the identification of different solitary pulmonary consolidation lesions.

Medicine (Baltimore) 2018 Aug;97(35):e11985

Shandong Medical Imaging Research Institute Affiliated to Shandong University.

The aim of the present study is to investigate the value of air bronchogram sign on computed tomography (CT) image in the differential diagnosis of solitary pulmonary consolidation lesions (SPLs).A total of 105 patients (including 39 cases of lung cancer, 43 cases of tuberculosis, and 23 cases of pneumonia) with SPLs were evaluated for the CT features of air bronchogram sign in this retrospective study. The shape and lumen of the bronchi with air bronchogram sign, the length of the involved bronchus with air bronchogram sign, the length of lesion on the same plane and direction, and the ratio between the length of the involved bronchus and that of the lesion were evaluated. Read More

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http://dx.doi.org/10.1097/MD.0000000000011985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392802PMC
August 2018
4 Reads
5.723 Impact Factor

Prediction of the Risk of Malignancy Among Detected Lung Nodules in the National Lung Screening Trial.

J Am Coll Radiol 2018 Nov 23;15(11):1529-1535. Epub 2018 Aug 23.

School of Management and Medical Informatics, Tabriz University of Medical Sciences, Tabriz, Iran.

Objectives: This study aimed to investigate nodule features and patient-specific characteristics associated with improvement in predictive ability of lung cancer screening while maintaining the sensitivity of low-dose CT intact.

Methods: All authors were approved to use data from the National Lung Screening Trial, a previously conducted randomized clinical trial, through submission of a proposal to the Cancer Data Access System. The National Lung Screening Trial had a multilevel design with nodules nested within rounds and rounds nested within individuals; hence, to incorporate nodule-level features, multilevel logistic regression was used. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15461440183074
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http://dx.doi.org/10.1016/j.jacr.2018.06.009DOI Listing
November 2018
10 Reads

Ultralow dose CT for follow-up of solid pulmonary nodules: A pilot single-center study using Bland-Altman analysis.

Medicine (Baltimore) 2018 Aug;97(34):e12019

Department of Radiology.

Solid pulmonary nodules are a common finding requiring serial computed tomography (CT) imaging. We sought to explore the detection and measurement accuracy of an ultralow-dose CT (ULDCT) protocol compared with our standard low-dose CT (LDCT) nodule follow-up protocol.In this pragmatic single-center pilot prospective cohort study, patients scheduled for clinically indicated CT surveillance of 1 or more known solid pulmonary nodules >2 mm underwent ULDCT immediately after routine LDCT. Read More

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http://dx.doi.org/10.1097/MD.0000000000012019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112944PMC
August 2018
9 Reads

Noninvasive pulmonary nodule characterization using transcutaneous bioconductance: Preliminary results of an observational study.

Medicine (Baltimore) 2018 Aug;97(34):e11924

Division of Radiology.

We sought to assess the use of an electro pulmonary nodule (EPN) scanner (FreshMedx, Salt Lake City, UT) in the noninvasive characterization of pulmonary nodules using transcutaneous bioconductance.Monocentric prospective study including patients with a pulmonary nodule identified on a chest computed tomography scan. Study protocol approved by the institutional review board and written consent was obtained for every patient. Read More

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http://Insights.ovid.com/crossref?an=00005792-201808240-0005
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http://dx.doi.org/10.1097/MD.0000000000011924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113006PMC
August 2018
9 Reads

[Minimally invasive resection of nonpalpable pulmonary nodules after wire- and isotope-guided localization].

Orv Hetil 2018 Aug;159(34):1399-1404

Mellkassebészeti Osztály, Országos Onkológiai Intézet Budapest, Ráth Gy. u. 7-9., 1122.

Introduction: Nowadays ever smaller, sub-centimetre lung nodules are screened and diagnosed. For these, minimally invasive resection is strongly recommended both with diagnostic and therapeutic purpose.

Aim: Despite many advantages of minimally invasive thoracic surgery, thorough palpation of the lung lobes and thus the localization of lung nodules are still limited. Read More

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http://dx.doi.org/10.1556/650.2018.31148DOI Listing
August 2018
2 Reads

Intraoperative fluorescence imaging in thoracic surgery.

J Surg Oncol 2018 Aug 11;118(2):344-355. Epub 2018 Aug 11.

Department of Surgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania.

Intraoperative fluorescence imaging (IFI) can improve real-time identification of cancer cells during an operation. Phase I clinical trials in thoracic surgery have demonstrated that IFI with second window indocyanine green (TumorGlow ) can identify subcentimeter pulmonary nodules, anterior mediastinal masses, and mesothelioma, while the use of a folate receptor-targeted near-infrared agent, OTL38, can improve the specificity for diagnosing tumors with folate receptor expression. Here, we review the existing preclinical and clinical data on IFI in thoracic surgery. Read More

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http://dx.doi.org/10.1002/jso.25149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146026PMC
August 2018
8 Reads

A novel CT-guided technique using medical adhesive for localization of small pulmonary ground-glass nodules and mixed ground-glass nodules (≤20 mm) before video-assisted thoracoscopic surgery.

Diagn Interv Radiol 2018 Jul;24(4):209-212

Department of Radiology, Beijing Hospital, National Center of Gerontology, Beijing, China.

Purpose: We aimed to evaluate the success rate and complication occurrence of CT-guided localization of small pure ground-glass nodules (pGGNs) and mixed ground-glass nodules (mGGNs) with medical adhesive injection before video-assisted thoracoscopic surgery (VATS).

Methods: From March 2015 to May 2017, 41 patients with 44 small pGGNs and mGGNs underwent CT-guided percutaneous localization with medical adhesive prior to wedge resection by VATS.

Results: Localization with medical adhesive was successful in all patients (100%). Read More

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http://dx.doi.org/10.5152/dir.2018.17315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045517PMC
July 2018
10 Reads