3,336 results match your criteria Solitary Pulmonary Nodule Imaging


Approaches to lung nodule risk assessment: clinician intuition versus prediction models.

J Thorac Dis 2020 Jun;12(6):3296-3302

Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Medical University of South Carolina, Charleston, SC, USA.

Pulmonary nodules are increasingly identified on imaging exams performed for a number of clinical presentations and can pose a diagnostic problem for clinicians. Guideline-directed management algorithms are structured on nodule pre-test probability of malignancy. The risk of malignancy can be clinician-assigned or calculated utilizing validated risk prediction calculators. Read More

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http://dx.doi.org/10.21037/jtd.2020.03.68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330782PMC

A CT-based radiomics nomogram for prediction of lung adenocarcinomas and granulomatous lesions in patient with solitary sub-centimeter solid nodules.

Cancer Imaging 2020 Jul 8;20(1):45. Epub 2020 Jul 8.

Department of Radiology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong Province, 519000, People's Republic of China.

Purpose: To develop a radiomics nomogram based on computed tomography (CT) images that can help differentiate lung adenocarcinomas and granulomatous lesions appearing as sub-centimeter solid nodules (SCSNs).

Materials And Methods: The records of 214 consecutive patients with SCSNs that were surgically resected and histologically confirmed as lung adenocarcinomas (n = 112) and granulomatous lesions (n = 102) from 2 medical institutions between October 2011 and June 2019 were retrospectively analyzed. Patients from center 1 ware enrolled as training cohort (n = 150) and patients from center 2 were included as external validation cohort (n = 64), respectively. Read More

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http://dx.doi.org/10.1186/s40644-020-00320-3DOI Listing

Detection of Solitary Pulmonary Nodules Based on Brain-Computer Interface.

Comput Math Methods Med 2020 15;2020:4930972. Epub 2020 Jun 15.

Department of Radiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.

Solitary pulmonary nodules are the main manifestation of pulmonary lesions. Doctors often make diagnosis by observing the lung CT images. In order to further study the brain response structure and construct a brain-computer interface, we propose an isolated pulmonary nodule detection model based on a brain-computer interface. Read More

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http://dx.doi.org/10.1155/2020/4930972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312740PMC

[The clinical characteristics and surgical management of ciliated muconodular papillary tumor].

Zhonghua Zhong Liu Za Zhi 2020 Jun;42(6):491-494

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To investigate the clinical characteristics and surgical management based on the clinical manifestation, pathological feature and the medical imaging finding of ciliated muconodular papillary tumor (CMPT). The data of clinical manifestation, pathological feature and the medical imaging finding of 15 patients with CMPT who received surgical treatment from January 2017 to April 2019 were collected and retrospectively analyzed. CMPT generally occurred in the elderly people. Read More

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http://dx.doi.org/10.3760/cma.j.cn112152-20190829-00555DOI Listing

Features of IgG4-related lung disease on 18F-FDG PET/computed tomography imaging.

Nucl Med Commun 2020 Jun 17. Epub 2020 Jun 17.

Department of Nuclear Medicine, Zhongshan Hospital, Fudan University.

Objectives: The aim of the study was to summarize the features of immunoglobulin G4-related lung disease (IgG4-RLD) on fluorine 18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT).

Methods: In this retrospective case series, 12 consecutive patients (9 men and 3 women, mean age 55.4 ± 13. Read More

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http://dx.doi.org/10.1097/MNM.0000000000001238DOI Listing

Role of Computed Tomography-guided Biopsies in the Era of Electromagnetic Navigational Bronchoscopy: A Retrospective Study of Factors Predicting Diagnostic Yield in Electromagnetic Navigational Bronchoscopy and Computed Tomography Biopsies.

J Clin Imaging Sci 2020 6;10:33. Epub 2020 Jun 6.

Departments of Radiology, University of Missouri, Columbia, Missouri, United States.

Objectives: Over 25% of the high-risk population screened for lung cancer have an abnormal computed tomography (CT) scan. Conventionally, these lesions have been biopsied with CT guidance with a high diagnostic yield. Electromagnetic navigational bronchoscopy (ENB) with transbronchial biopsy has emerged as a technology that improves the diagnostic sensitivity of conventional bronchoscopic biopsy. Read More

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http://dx.doi.org/10.25259/JCIS_53_2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294316PMC

The effect of the reconstruction algorithm for the pulmonary nodule detection under the metal artifact caused by a pacemaker.

Medicine (Baltimore) 2020 Jun;99(24):e20579

From the Department of Radiology, Osaka University Graduate School of Medicine, Suita-city.

The aim was to compare the effects of metal artifacts from a pacemaker on pulmonary nodule detection among computed tomography (CT) images reconstructed using filtered back projection (FBP), single-energy metal artifact reduction (SEMAR), and forward-projected model-based iterative reconstruction solution (FIRST).Nine simulated nodules were placed inside a chest phantom with a pacemaker. CT images reconstructed using FBP, SEMAR, and FIRST were acquired at low and standard dose, and were evaluated by 2 independent radiologists. Read More

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http://dx.doi.org/10.1097/MD.0000000000020579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302625PMC

Measurement accuracy of lung nodule volumetry in a phantom study: Effect of axial-volume scan and iterative reconstruction algorithm.

Medicine (Baltimore) 2020 Jun;99(23):e20543

Department of Radiology, Kyung Hee University Hospital, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.

An axial-volume scan with adaptive statistical iterative reconstruction-V (ASIR-V) is newly developed. Our goal was to identify the influence of axial-volume scan and ASIR-V on accuracy of automated nodule volumetry.An "adult' chest phantom containing various nodules was scanned using both helical and axial-volume modes at different dose settings using 256-slice CT. Read More

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http://dx.doi.org/10.1097/MD.0000000000020543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306330PMC

Discriminating between bronchiolar adenoma, adenocarcinoma in situ and minimally invasive adenocarcinoma of the lung with CT.

Diagn Interv Imaging 2020 May 29. Epub 2020 May 29.

Department of Radiology, The Second Hospital of Jilin University, Changchun, 130041 Jilin, China.

Purpose: To identify computed tomography (CT) features that may help distinguish bronchiolar adenoma (BA) from lung adenocarcinomas in situ (AIS) and minimally invasive adenocarcinomas (MIA) among lung lesions presenting as ground-glass nodules (GGNs).

Materials And Methods: A total of 140 patients with GGNs confirmed by surgery and pathology, were reviewed retrospectively. There were 68 men and 72 women with a mean age of 64. Read More

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http://dx.doi.org/10.1016/j.diii.2020.05.005DOI Listing

Adenocarcinoma of the lung: from BAC to the future.

Insights Imaging 2020 May 19;11(1):69. Epub 2020 May 19.

St James's Hospital, Dublin, 8, Ireland.

Adenocarcinoma in situ, minimally invasive adenocarcinoma, lepidic predominant adenocarcinoma and invasive mucinous adenocarcinoma are relatively new classification entities which replace the now retired term, bronchoalveolar carcinoma (BAC). The radiographic appearance of these lesions ranges from pure, ground glass nodules to large, solid masses. A thorough understanding of the new classification is essential to radiologists who work with MDT colleagues to provide accurate staging and treatment. Read More

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http://dx.doi.org/10.1186/s13244-020-00875-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237554PMC

PET/CT and the solitary pulmonary nodule.

Radiol Bras 2020 Mar-Apr;53(2):VII-VIII

Honorary Professor of Thoracic Imaging, The University of Manchester, Co-lead for Thoracic Imaging, Department of Radiology, Manchester University NHS Foundation Trust.

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http://dx.doi.org/10.1590/0100-3984.2020.53.2e2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170579PMC

Small Solitary Ground-Glass Nodule on CT as an Initial Manifestation of Coronavirus Disease 2019 (COVID-19) Pneumonia.

Korean J Radiol 2020 05;21(5):545-549

Department of Radiology, China Resources & WISCO General Hospital, Wuhan, China.

The 2019 novel coronavirus (2019-nCoV) outbreak in Wuhan, Hubei Province, China in 2019 led to large numbers of people being infected and developing atypical pneumonia (coronavirus disease 2019, COVID-19). Typical imaging manifestations of patients infected with 2019-nCoV has been reported, but we encountered an atypical radiological manifestation on baseline computed tomography (CT) images in three patients from Wuhan, China infected with the 2019-nCoV. Surprisingly, the only similar CT finding was a solitary sub-centimeter ground-glass nodule adjacent to bronchovascular bundles, which could be easily overlooked. Read More

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http://dx.doi.org/10.3348/kjr.2020.0240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183840PMC

[Radiation dose and image quality of noncontrast chest CT in domestic and imported main stream manufacturers].

Zhonghua Yi Xue Za Zhi 2020 Apr;100(15):1148-1153

Department of Radiology, Tianjin Union Medical Center, Tianjin 300121, China.

To compare the radiation dose and image quality of noncontrast chest CT and detection of ground-glass opacity pulmonary nodules (GGN) in domestic 128-slice spiral CT with the other CT scanners from three main stream manufacturers. From May 8, 2018 to October 31, 2018, noncontrast chest CT images from Neusoft 128-slice CT (75 males, 25 females, (42±16) years), dual-source 64-slice CT (53 males, 47 females, (50±16) years) and dual-source 128-slice CT scanners(69 males, 31 females, (62±17) years), Toshiba 128-slice CT (51 males, 49 females, (58±13) years) and GE 128-slice CT scanner (55 males, 45 females, (60±10) years) were collected in Eastern Theater Command and Tianjin People's Hospital. Radiation dose and image quality were evaluated. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20190903-01957DOI Listing

Predictive model for the diagnosis of benign/malignant small pulmonary nodules.

Medicine (Baltimore) 2020 Apr;99(15):e19452

Taizhou First People's Hospital, Taizhou, Zhejiang, China.

There is some doubt that all nodules <8 mm are really mainly benign and that simple follow-up is adequate in all cases. The purpose of this study is to create a predictive model for the diagnosis of benign and malignant small pulmonary nodules.This was a retrospective case-control study of patients who had undergone pulmonary nodule resection at the Zhejiang University Jinhua Hospital. Read More

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http://dx.doi.org/10.1097/MD.0000000000019452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220466PMC

A Subsolid Nodules Imaging Reporting System (SSN-IRS) for Classifying 3 Subtypes of Pulmonary Adenocarcinoma.

Clin Lung Cancer 2020 Jul 6;21(4):314-325.e4. Epub 2020 Feb 6.

Department of Radiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Centre of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, The People's Republic of China. Electronic address:

Objectives: To develop an imaging reporting system for the classification of 3 adenocarcinoma subtypes of computed tomography (CT)-detected subsolid pulmonary nodules (SSNs) in clinical patients.

Methods: Between November 2011 and October 2017, 437 pathologically confirmed SSNs were retrospectively identified. SSNs were randomly divided 2:1 into a training group (291 cases) and a testing group (146 cases). Read More

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http://dx.doi.org/10.1016/j.cllc.2020.01.014DOI Listing

Pulmonary adenocarcinoma appearing as ground-glass opacity nodules identified using non-enhanced and contrast-enhanced CT texture analysis: A retrospective analysis.

Exp Ther Med 2020 Apr 10;19(4):2483-2490. Epub 2020 Feb 10.

Department of Medical Imaging, Yangzhou University Clinical College Subei People's Hospital, Yangzhou, Jiangsu 225002, P.R. China.

The present study aimed to investigate the ability of CT-based texture analysis to differentiate invasive adenocarcinoma (IA) from pre-invasive lesions (PIL) or minimally IA (MIA) appearing as ground-glass opacity (GGO) nodules, and to further compare the performance of non-enhanced CT (NECT) images with that of contrast-enhanced CT (CECT) images. A total of 77 patients with GGO nodules and surgically confirmed pulmonary adenocarcinoma were included in the present retrospective study. Each GGO nodule was manually segmented and its texture features were extracted from NECT and CECT images using in-house developed software coded in MATLAB (MathWorks). Read More

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http://dx.doi.org/10.3892/etm.2020.8511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086215PMC

Differences in the clinical management of women and men after detection of a solitary pulmonary nodule in clinical practice.

Eur Radiol 2020 Aug 19;30(8):4390-4397. Epub 2020 Mar 19.

Public Health, History of Science and Gynaecology Department, Miguel Hernández University, Nacional Road N-332, s/n, 03550, San Juan de Alicante, Alicante, Spain.

Objectives: To explore differences in the clinical management of men and women in the 5 years after detecting a solitary pulmonary nodule (SPN) by chest radiograph or CT in routine clinical practice.

Methods: We followed up 545 men and 347 women with an SPN detected by chest radiograph or CT in a retrospective cohort of 25,422 individuals undergoing routine thoracic imaging in 2010-2011. We compared the frequency of each management strategy (no further test, immediate intervention or follow up) according to sex by means of chi-squared. Read More

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http://dx.doi.org/10.1007/s00330-020-06791-zDOI Listing

Image-guided video-assisted thoracoscopic resection (iVATS): Translation to clinical practice-real-world experience.

J Surg Oncol 2020 Jun 12;121(8):1225-1232. Epub 2020 Mar 12.

Department of Surgery, Brigham & Women's Hospital, Boston, Massachusetts.

Objective: We developed a novel approach for localization and resection of lung nodules, using image-guided video-assisted thoracoscopic surgery (iVATS). We report our experience of translating iVATS into clinical care.

Methods: Methodology and workflow for iVATS developed as part of the Phase I/II trial were used to train surgeons, radiologists, anesthesiologists, and radiology technologists. Read More

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http://dx.doi.org/10.1002/jso.25897DOI Listing

A model of malignant risk prediction for solitary pulmonary nodules on F-FDG PET/CT: Building and estimating.

Thorac Cancer 2020 May 12;11(5):1211-1215. Epub 2020 Mar 12.

PET/CT Center, the Affiliated Hospital of Qingdao University, Qingdao, China.

Background: To develop a model of malignant risk prediction of solitary pulmonary nodules (SPNs) using metabolic characteristics of lesions.

Methods: A total of 362 patients who underwent PET/CT imaging from January 2013 to July 2017 were analyzed. Differences in the clinical and imaging characteristics were analyzed between patients with benign SPNs and those with malignant SPNs. Read More

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http://dx.doi.org/10.1111/1759-7714.13375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180535PMC

Radiomics for lung adenocarcinoma manifesting as pure ground-glass nodules: invasive prediction.

Eur Radiol 2020 Jul 11;30(7):3650-3659. Epub 2020 Mar 11.

Department of Radiology, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040, China.

Objectives: To investigate the value of radiomics based on CT imaging in predicting invasive adenocarcinoma manifesting as pure ground-glass nodules (pGGNs).

Methods: This study enrolled 395 pGGNs with histopathology-confirmed benign nodules or adenocarcinoma. A total of 396 radiomic features were extracted from each labeled nodule. Read More

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http://dx.doi.org/10.1007/s00330-020-06776-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305264PMC

[Clinical analysis of 30 cases of Castleman disease with different types of thoracic involvement].

Zhonghua Xue Ye Xue Za Zhi 2020 Feb;41(2):149-156

National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou 510120, China.

To improve the clinical understanding of Castleman disease (CD) with different types of thoracic involvement, including their clinical features, radiological and pathological findings, diagnosis and current treatment strategies. Retrospective analysis of 30 patients diagnosed with CD with thoracic involvement and hospitalized between June 2009 and May 2019 in The First Affiliated Hospital of Guangzhou Medical University was performed. Patients were divided into three groups for subsequent analysis based on the clinical data: CD with bronchiolitis obliterans (BO) , unicentric Castleman disease (UCD) without BO, and multicentric Castleman disease (MCD) without BO. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2020.02.012DOI Listing
February 2020

Towards more accurate F-fluorodeoxyglucose positron emission tomography (F-FDG PET) imaging in active and latent tuberculosis.

Int J Infect Dis 2020 Mar 27;92S:S85-S90. Epub 2020 Feb 27.

Institute of Nuclear Medicine, UCLH NHS Foundation Trust, 235 Euston Road, London NW1 2BU, United Kingdom. Electronic address:

Tuberculosis (TB) is one of the leading causes of death worldwide. Although the disease is curable and preventable, it is underdiagnosed in many parts of the world. Positron emission tomography (PET) imaging using F-FDG in TB can localise disease sites and the extent of disease. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.02.017DOI Listing

An ectopic Cushing's syndrome as a cause of severe refractory hypokalemia in the ICU.

Acta Clin Belg 2020 Feb 23:1-6. Epub 2020 Feb 23.

Department of Intensive Care, Brugmann University Hospital, Brussels, Belgium.

: Ectopic Cushing's syndrome is a very rare condition caused by an ACTH-secreting tumor outside the pituitary or adrenal glands, and the majority of these cases are encountered in the context of paraneoplastic syndromes. The ectopic source of ACTH secretion is not always obvious to detection and can be challenging. We report a rare case, in which a hidden ACTH-secreting carcinoid tumor of the lung caused a severe refractory hypokalemia, leading us to a race against time to locate the tumor. Read More

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http://dx.doi.org/10.1080/17843286.2020.1734162DOI Listing
February 2020

Comparison of the diagnostic accuracy of diffusion-weighted magnetic resonance imaging and positron emission tomography/computed tomography in pulmonary nodules: a prospective study.

Pol J Radiol 2019 27;84:e498-e503. Epub 2019 Nov 27.

Department of Chest Diseases, University of Health Sciences, Haseki Training and Research Hospital, Istanbul, Turkey.

Purpose: Computed tomography (CT) and positron emission tomography (PET) are the mainstay imaging methods in the evaluation and follow-up of pulmonary nodules. But they both have high radiation risk for patients. Diffusion- weighted magnetic resonance imaging (DW-MRI), on the other hand, is a radiation free imaging method that gives information about the biological structure of tissues at the molecular level by measuring random movement of water in biological tissues. Read More

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http://dx.doi.org/10.5114/pjr.2019.91200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016491PMC
November 2019

Multiple sclerosing hemangioma of the right lung in a 23-year-old female patient: A case report and review of the literature.

Mol Clin Oncol 2020 Mar 22;12(3):263-267. Epub 2020 Jan 22.

Department of Pulmonary and Critical Care Medicine, General Hospital of Western Theater Command, Chengdu, Sichuan 610083, P.R. China.

Pulmonary sclerosing hemangioma (PSH) is a relatively uncommon benign tumor of the lung, predominantly affecting young and middle-aged women. In the majority of the patients, PSH is incidentally found on physical examination and typically presents as a solitary nodule with smooth borders, as it is generally asymptomatic or lacks typical symptoms. In the present case, a 23-year-old woman was incidentally diagnosed with pulmonary nodules during routine physical examination and reported suffering from intermittent fevers for >2 months. Read More

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http://dx.doi.org/10.3892/mco.2020.1986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016522PMC

The combination of CTCs and CEA can help guide the management of patients with SPNs suspected of being lung cancer.

BMC Cancer 2020 Feb 10;20(1):106. Epub 2020 Feb 10.

Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiaotong University, 85Wujin Road, Shanghai, 200080, China.

Objective: Solitary pulmonary nodules (SPNs) is a common radiographic finding and require further evaluation because of the possibility of lung cancer. This study aimed to determine the sensitivity and specificity of circulating tumour cells (CTCs) as a marker for the diagnosis of SPNs and the integration of CTCs, carcinoembryonic antigen (CEA) and imaging findings to improve the sensitivity and specificity of diagnosis in patients with SPNs suspected of being lung cancer.

Method: For the serum biomarker assay, the concentration of CEA was measured by an automated electrochemiluminescence analyzer. Read More

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http://dx.doi.org/10.1186/s12885-020-6524-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011271PMC
February 2020

Ciliated Muconodular Papillary Tumor of the Lung: Thin-Section CT Findings of 16 Cases.

AJR Am J Roentgenol 2020 04 22;214(4):761-765. Epub 2020 Jan 22.

Department of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan.

The purpose of this article was to assess thin-section CT features of ciliated muconodular papillary tumors (CMPTs) of the lung and correlations between radiologic and pathologic findings. Thin-section CT findings of 16 patients (10 men and six women; mean age, 70.7 years) with surgically resected CMPTs were retrospectively analyzed. Read More

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http://dx.doi.org/10.2214/AJR.19.21945DOI Listing

Quantitative pathologic analysis of pulmonary nodules using three-dimensional computed tomography images based on latent Dirichlet allocation.

Conf Proc IEEE Eng Med Biol Soc 2019 07;2019:6255-6258

The main purpose of this paper is to quantificationally predict the pathologic characteristics of pulmonary nodules using a novel and effective computer assisted diagnosis (CADx) scheme based on latent Dirichlet allocation (LDA) model. To make use of LDA model, we propose a novel 3D rotation invariant LBP feature to construct image words through the K-means algorithm from 3D pulmonary nodule slices. A topic distribution for each pulmonary nodule can be acquired by well-trained LDA model, which was used for pathologic analysis based on rank-based statistical analysis. Read More

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http://dx.doi.org/10.1109/EMBC.2019.8856964DOI Listing

Nonspecific benign pathological results on computed tomography-guided lung biopsy: A predictive model of true negatives.

J Cancer Res Ther 2019 ;15(7):1464-1470

Department of Radiology, Xuzhou Central Hospital, Xuzhou, China.

Objective: The aim of this study is to develop a predictive model for identifying true negatives among nonspecific benign results on computed tomography-guided lung biopsy.

Materials And Methods: This was a single-center retrospective study. Between December 2013 and May 2016, a total of 126 patients with nonspecific benign biopsy results were used as the training group to create a predictive model of true-negative findings. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_109_19DOI Listing

Interobserver agreement of the visual Herder scale for the assessment of solitary pulmonary nodules on 18F Fluorodeoxyglucose PET/computed tomography.

Nucl Med Commun 2020 Mar;41(3):235-240

Department of Imaging, Charing Cross Hospital.

Background: British Thoracic Society guidelines recommend 18F Fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) for solitary pulmonary nodule (SPN) follow-up in high-risk individuals or if the CT Brock score is >10%. Nodule tracer uptake is assessed visually in comparison to the surrounding lung tissue and mediastinal blood pool (Herder score). This score is used to calculate the risk of malignancy and guide patient management. Read More

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http://dx.doi.org/10.1097/MNM.0000000000001146DOI Listing

Classification of lung nodules based on CT images using squeeze-and-excitation network and aggregated residual transformations.

Radiol Med 2020 Apr 8;125(4):374-383. Epub 2020 Jan 8.

School of Mechanical Engineering, Tianjin University, Tianjin, 300350, China.

Lung cancer is pointed as a leading cause of cancer death worldwide. Early lung nodule diagnosis has great significance for treating lung cancer and increasing patient survival. In this paper, we present a novel method to classify the malignant from benign lung nodules based on CT images using squeeze-and-excitation network and aggregated residual transformations (SE-ResNeXt). Read More

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http://dx.doi.org/10.1007/s11547-019-01130-9DOI Listing

Qualitative and quantitative imaging features of pulmonary subsolid nodules: differentiating invasive adenocarcinoma from minimally invasive adenocarcinoma and preinvasive lesions.

J Thorac Dis 2019 Nov;11(11):4835-4846

Department of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Background: To explore the role of qualitative and quantitative imaging features of pulmonary subsolid nodules (SSNs) in differentiating invasive adenocarcinoma (IAC) from minimally invasive adenocarcinoma (MIA) and preinvasive lesions.

Methods: We reviewed the clinical records of our institute from October 2010 to December 2015 and included 316 resected SSNs from 287 patients: 260 pure ground-glass nodules, 47 part-solid nodules with solid components ≤5 mm, and 9 ground-glass nodules (GGNs) with cystic airspaces. According to the pathologic review results, 307 SSNs in addition to nine GGNs with cystic airspaces were divided into two groups: A, including atypical adenomatous hyperplasia (AAH) (n=15), adenocarcinoma in situ (AIS) (n=56), and MIA (n=41); B, including 195 IACs. Read More

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http://dx.doi.org/10.21037/jtd.2019.11.35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940263PMC
November 2019

[A review of deep learning methods for the detection and classification of pulmonary nodules].

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2019 Dec;36(6):1060-1068

Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine & Health Sciences, Shanghai 201318, P.R.China.

Lung cancer has the highest mortality rate among all malignant tumors. The key to reducing lung cancer mortality is the accurate diagnosis of pulmonary nodules in early-stage lung cancer. Computer-aided diagnostic techniques are considered to have potential beyond human experts for accurate diagnosis of early pulmonary nodules. Read More

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http://dx.doi.org/10.7507/1001-5515.201903027DOI Listing
December 2019

Solitary Pulmonary Nodule: A Diagnostic Dilemma.

Case Rep Pulmonol 2019 21;2019:5242634. Epub 2019 Nov 21.

Assistant Professor of Medicine, Pulmonary & Critical Care, SUNY Upstate Medical University, Syracuse, USA.

This case describes a woman with a history of tobacco abuse who presented with a dry cough and was found to have an enlarging, 4 cm right upper lobe nodule without lymphadenopathy on CT imaging of the chest. Initial biopsies of the nodule suggested follicular lymphoma, but after obtaining more tissue, the pathology was negative for malignancy and instead showed necrotizing pneumonia. She proceeded to have negative infectious serology and cultures. Read More

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http://dx.doi.org/10.1155/2019/5242634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906797PMC
November 2019

Evaluation of the diagnostic efficacy of F-Fluorine-2-Deoxy-D-Glucose PET/CT for lung cancer and pulmonary tuberculosis in a Tuberculosis-endemic Country.

Cancer Med 2020 Feb 13;9(3):931-942. Epub 2019 Dec 13.

Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objective: To determine the diagnostic efficacy of F-FDG PET/CT in distinguishing between pulmonary tuberculosis (PTB) and lung cancer in solitary pulmonary nodule (SPN) in a country with a high prevalence of PTB.

Methods: Patients with SPN who underwent F-FDG PET/CT imaging were retrospectively included in the study. The final diagnosis was established by histopathology. Read More

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http://dx.doi.org/10.1002/cam4.2770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997090PMC
February 2020

Coexistence of nontuberculous mycobacterium and IgG4-related disease in a solitary pulmonary nodule: A case report.

Medicine (Baltimore) 2019 Nov;98(48):e18179

Department of Internal medicine, Gyeongsang National University School of Medicine, Jinju, South Korea.

Rationale: Immunoglobulin G4-related disease (IgG4-RD) is regarded as an immune-mediated systemic fibroinflammatory disease. Several studies have linked IgG4-RD to infections such as tuberculosis and actinomycosis. However, the coexistence of IgG4-RD and non-tuberculous mycobacterium (NTM) in a single pulmonary nodule has not been reported yet. Read More

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http://dx.doi.org/10.1097/MD.0000000000018179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890359PMC
November 2019

[Artificial intelligence evaluation of simulated phantom lung nodules with different pre-adaptive iteration techniques].

Zhonghua Yi Xue Za Zhi 2019 Nov;99(43):3424-3427

Nation Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China.

To investigate the detection rate of pulmonary nodules and the accuracy of automated measurement in chest simulation phantom by artificial intelligent computer-aided detection of pulmonary nodules with different pre-adaptive iterative techniques (ASIR-V) in wide-spectrum CT scanning. Sixteen pulmonary nodules with different diameters, densities and shapes were placed in the chest simulation phantom from December 2017 to March 2018. The weight of ASIR-V was set at 0%, 20%, 30%, 40% and 50% respectively by using Revolution CT broadband energy spectrum scanning protocol. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.43.015DOI Listing
November 2019

The Effect of Visual Hindsight Bias on Radiologist Perception.

Acad Radiol 2020 Jul 15;27(7):977-984. Epub 2019 Nov 15.

Discipline of Medical Radiation Sciences, Faculty of Health Sciences, University of Sydney, Cumberland Campus, 75 East Street, Lidcombe, NSW 2141, Australia; Medical Imaging Optimisation Perception Group, Discipline of Medical Radiation Sciences, Faculty of Health Sciences, University of Sydney, Lidcombe, New South Wales, Australia.

Rationale And Objectives: To measure the effect of visual hindsight bias on radiologists' perception during chest radiograph pulmonary nodule detection.

Materials And Methods: This was a prospective multi-observer study to assess the effect of hindsight bias on radiologists' perception. Sixteen radiologists were asked to interpret 15 postero-anterior chest images containing a solitary lung nodule each consisting of 25 incremental levels of blur. Read More

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http://dx.doi.org/10.1016/j.acra.2019.09.032DOI Listing

Hook-wire localization versus lipiodol localization for patients with pulmonary lesions having ground-glass opacity.

J Thorac Cardiovasc Surg 2020 04 30;159(4):1571-1579.e2. Epub 2019 Sep 30.

Department of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:

Objectives: Accurate and safe preoperative localization is useful for video-assisted thoracic surgery of small pulmonary lesions with ground-glass opacity (GGO). However, the optimal localization method is unclear. The aim of this study was to compare the usefulness and safety of the lipiodol and hook-wire localization techniques for video-assisted thoracic surgery of GGO lesions. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2019.08.100DOI Listing

Multiplanar analysis for pulmonary nodule classification in CT images using deep convolutional neural network and generative adversarial networks.

Int J Comput Assist Radiol Surg 2020 Jan 16;15(1):173-178. Epub 2019 Nov 16.

Gifu University, 1-1 Yanagido, Gifu, 501-1194, Japan.

Purpose: Early detection and treatment of lung cancer holds great importance. However, pulmonary-nodule classification using CT images alone is difficult to realize. To address this concern, a method for pulmonary-nodule classification based on a deep convolutional neural network (DCNN) and generative adversarial networks (GAN) has previously been proposed by the authors. Read More

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http://dx.doi.org/10.1007/s11548-019-02092-zDOI Listing
January 2020

Deep Convolutional Neural Network-based Software Improves Radiologist Detection of Malignant Lung Nodules on Chest Radiographs.

Radiology 2020 01 12;294(1):199-209. Epub 2019 Nov 12.

From the Department of Radiology, Research Institute of Radiological Science, Center for Clinical Imaging Data Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea (Y.S., K.H., B.W.C.); Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (M.J.C.); Department of Radiology, University Medical Center Freiburg, Freiburg, Germany (E.K.); Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass (S. Yune, M.K., S.D.); and Samsung Electronics, Suwon, Republic of Korea (H.K., S. Yang, D.J.L.).

Background Multicenter studies are required to validate the added benefit of using deep convolutional neural network (DCNN) software for detecting malignant pulmonary nodules on chest radiographs. Purpose To compare the performance of radiologists in detecting malignant pulmonary nodules on chest radiographs when assisted by deep learning-based DCNN software with that of radiologists or DCNN software alone in a multicenter setting. Materials and Methods Investigators at four medical centers retrospectively identified 600 lung cancer-containing chest radiographs and 200 normal chest radiographs. Read More

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http://dx.doi.org/10.1148/radiol.2019182465DOI Listing
January 2020

Incidental pulmonary nodule frequency in Turkey.

Tuberk Toraks 2019 Sep;67(3):190-196

Department of Chest Diseases, Faculty of Medicine, Hitit University, Corum, Turkey.

Introduction: Pulmonary nodules are common incidental findings on computed tomography (CT). In Turkey, there is no available data about the follow-up of the frequency of incidental nodules. Our aim is to assess the frequency and size distrubition of incidental pulmonary nodule in our country. Read More

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http://dx.doi.org/10.5578/tt.68532DOI Listing
September 2019

Alveolar adenoma with poor imaging: a case report.

J Int Med Res 2019 Nov 10:300060519885269. Epub 2019 Nov 10.

Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

Alveolar adenoma is an isolated, well-defined peripheral lung tumor that originates from type II alveolar cells. The tumor consists of a network of simple, low-cubic, epithelium-coated lacunae with varying amounts of fine and inconspicuous-to-thick spindle cells that sometimes contain mucus sample matrix. Few cases of alveolar adenoma have been reported. Read More

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http://dx.doi.org/10.1177/0300060519885269DOI Listing
November 2019

Diagnosis and outcome of resected solitary pulmonary nodules after liver transplantation.

Jpn J Clin Oncol 2020 Feb;50(2):193-197

Department of Medical Oncology, Japanese Red Cross Medical Center, Tokyo, Japan.

Objective: Solitary pulmonary nodules after liver transplantation are challenging clinical problems. Herein, we report the causes and clinical courses of resected solitary pulmonary nodules in patients who underwent liver transplantation.

Methods: We retrospectively obtained medical records of 68 patients who underwent liver transplantation between March 2009 and June 2016. Read More

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http://dx.doi.org/10.1093/jjco/hyz159DOI Listing
February 2020

Solid Indeterminate Nodules with a Radiological Stability Suggesting Benignity: A Texture Analysis of Computed Tomography Images Based on the Kurtosis and Skewness of the Nodule Volume Density Histogram.

Pulm Med 2019 7;2019:4071762. Epub 2019 Oct 7.

Post-graduate Programme in Medical Sciences, School of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil.

Background: The number of incidental findings of pulmonary nodules using imaging methods to diagnose other thoracic or extrathoracic conditions has increased, suggesting the need for in-depth radiological image analyses to identify nodule type and avoid unnecessary invasive procedures.

Objectives: The present study evaluated solid indeterminate nodules with a radiological stability suggesting benignity (SINRSBs) through a texture analysis of computed tomography (CT) images.

Methods: A total of 100 chest CT scans were evaluated, including 50 cases of SINRSBs and 50 cases of malignant nodules. Read More

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http://dx.doi.org/10.1155/2019/4071762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800929PMC
March 2020
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Multidisciplinary selection of pulmonary nodules for surgical resection: Diagnostic results and long-term outcomes.

J Thorac Cardiovasc Surg 2020 04 24;159(4):1558-1566.e3. Epub 2019 Sep 24.

Division of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, Mass. Electronic address:

Objective: Pulmonary nodules found incidentally or by lung cancer screening differ in prevalence, risk profile, and diagnostic intervention. The results of surgical intervention for incidental versus screening lung nodules during multidisciplinary Pulmonary Nodule and Lung Cancer Screening Clinic (PNLCSC) follow-up have not been reported.

Methods: All patients evaluated at a PNLCSC from 2012 to 2018 following referral by primary care physicians, specialist physicians, or self-referral after computed tomography (CT) identified nodules on routine diagnostic CT (incidental group) or lung cancer screening CT (screening group) were included. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2019.09.030DOI Listing

Three-dimensional mean CT attenuation value of pure and part-solid ground-glass lung nodules may predict invasiveness in early adenocarcinoma.

Clin Radiol 2019 Dec 18;74(12):944-949. Epub 2019 Oct 18.

Department of General Thoracic Surgery, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575 Japan. Electronic address:

Aim: This study evaluated the relationship between three-dimensional (3D) mean computed tomography (CT) attenuation values of ground-glass nodules (GGN) and pathological invasiveness in early lung adenocarcinoma. The diagnostic accuracy of 3D CT attenuation values was compared with that of two-dimensional (2D) CT attenuation values and standardised uptake value on positron-emission tomography (PET).

Materials And Methods: Surgical and radiological data from 96 pure or part-solid GGNs of <20 mm were analysed retrospectively. Read More

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http://dx.doi.org/10.1016/j.crad.2019.09.130DOI Listing
December 2019

Pulmonary Cryptococcus infections as a manifestation of idiopathic CD4 lymphocytopenia: case report and literature review.

BMC Infect Dis 2019 Oct 17;19(1):862. Epub 2019 Oct 17.

Division of Infectious Diseases, Department of Medicine, University of Calgary, Calgary, AB, Canada.

Background: Idiopathic CD4 lymphocytopenia (ICL) is a rare clinical disease with relative CD4 deficiency in the absence of HIV infection. The pathogenicity of ICL is poorly understood with an unclear incidence rate in the general population. Sequelae of ICL includes AIDS-defining infections, which most commonly includes Cryptococcus neoformans. Read More

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http://dx.doi.org/10.1186/s12879-019-4453-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798450PMC
October 2019
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