5,149 results match your criteria Solitary Pulmonary Nodule


[Surgical Cases of Solitary Lesion after Surgery for Primary Lung Cancer].

Kyobu Geka 2021 May;74(5):331-335

Department of Thoracic Surgery, Tokyo Women's Medical University, Tokyo, Japan.

Lung nodules during postoperative follow-up of lung cancer are generally suspected to be its recurrence, but some cases are diagnosed as non-malignant disease. From January 2001 to November 2018, we experienced 5( 4.5%) new non-malignant lesions in 112 lung cancer patients who underwent a lung resection. Read More

View Article and Full-Text PDF

Type A thymoma with simultaneous solitary intrapulmonary metastasis: A case report.

Thorac Cancer 2021 May 7. Epub 2021 May 7.

Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

A 79-year-old woman was referred to our facility because of an abnormal chest shadow. Chest computed tomography (CT) showed a solitary right middle lung nodule with a maximum diameter of 3 mm and anterior mediastinal nodule with a maximum diameter of 21 mm. The lung nodule was suspected of being a primary lung cancer rather than a metastatic tumor because there were no primary malignant tumors, apart from an anterior mediastinal tumor visible on diagnostic imaging, including F fluorodeoxyglucose-positron emission tomography, and a solitary lung nodule. Read More

View Article and Full-Text PDF

Proposing a deep learning-based method for improving the diagnostic certainty of pulmonary nodules in CT scan of chest.

Eur Radiol 2021 May 6. Epub 2021 May 6.

Deepwise AI Lab, Beijing, China.

Objective: To compare the performance of a deep learning (DL)-based method for diagnosing pulmonary nodules compared with radiologists' diagnostic approach in computed tomography (CT) of the chest.

Materials And Methods: A total of 150 pathologically confirmed pulmonary nodules (60% malignant) assessed and reported by radiologists were included. CT images were processed by the proposed DL-based method to generate the probability of malignancy (0-100%), and the nodules were divided into the groups of benign (0-39. Read More

View Article and Full-Text PDF

Usefulness of dynamic fluorodeoxyglucose positron emission tomography/computed tomography in diagnosing pulmonary arteriovenous malformation mimicking a lung tumour.

Interact Cardiovasc Thorac Surg 2021 May 5. Epub 2021 May 5.

Department of Chest Disease, Faculty of Medicine, Tokat Gaziosmanpasa University, Tokat, Turkey.

A 61-year-old male patient with known kidney dysfunction who underwent a non-contrast thorax CT and was then referred to our department for metabolic assessment of solitary pulmonary nodule (SPN). The patient underwent dynamic FDG PET/CT to differentiate benign from malignant SPN. This case illustrates the usefulness of dynamic FDG PET/CT imaging when assessing SPN especially in patients with suspicion for pulmonary arterio-venous malformation accompanying renal failure or contrast allergy. Read More

View Article and Full-Text PDF

Isolated Solitary Lung Nodule in a Patient With Idiopathic Pulmonary Fibrosis and Concomitant Prostate Cancer: A Challenging Diagnosis.

Cureus 2021 Mar 31;13(3):e14218. Epub 2021 Mar 31.

Department of Respiratory Medicine, National Coordinating Reference Centre for Rare Pulmonary Diseases, Louis Pradel Hospital, University Hospital of Lyon, Lyon, FRA.

Prostate cancer is the most commonly diagnosed malignancy and the second most common cause of death in men after lung cancer. Isolated pulmonary metastasis from prostate cancer, without bone or lymph node involvement, is rare and accounts for less than 1% of cases. The diagnosis of solitary lung metastasis is even more challenging in patients with concomitant pulmonary disease and often mandates tissue biopsy from the lung nodule. Read More

View Article and Full-Text PDF

A New Outlook on the Ability to Accumulate an Iodine Contrast Agent in Solid Lung Tumors Based on Virtual Monochromatic Images in Dual Energy Computed Tomography (DECT): Analysis in Two Phases of Contrast Enhancement.

J Clin Med 2021 Apr 26;10(9). Epub 2021 Apr 26.

Department of Internal Medicine, Pulmonology, Allergy and Clinical Immunology, Military Institute of Medicine, Szaserów 128, 04-141 Warsaw, Poland.

For some time, dual energy computed tomography (DECT) has been an established method used in a vast array of clinical applications, including lung nodule assessment. The aim of this study was to analyze (using monochromatic DECT images) how the X-ray absorption of solitary pulmonary nodules (SPNs) depends on the iodine contrast agent and when X-ray absorption is no longer dependent on the accumulated contrast agent. Sixty-six patients with diagnosed solid lung tumors underwent DECT scans in the late arterial phase (AP) and venous phase (VP) between January 2017 and June 2018. Read More

View Article and Full-Text PDF

Pre-Processing Method for Contouring the Uptake Levels of [18F] FDG for Enhanced Specificity of PET Imaging of Solitary Hypermetabolic Pulmonary Nodules.

J Clin Med 2021 Apr 1;10(7). Epub 2021 Apr 1.

Department of Nuclear Medicine, Medical University of Bialystok, M. Skłodowskiej-Curie St. 24A, 15-276 Bialystok, Poland.

Background: The paper presents a pre-processing method which, based on positron-emission tomography (PET) images of F-fluorodeoxyglucose ([18F] FDG) hypermetabolic pulmonary nodules, makes it possible to obtain additional visual characteristics and use them to enhance the specificity of imaging.

Material And Methods: A retrospective analysis of 69 FDG-PET/CT scans of solitary hypermetabolic pulmonary nodules (40 cases of lung cancer and 29 benign tumours), where in each case, the standardised uptake value of the hottest voxel within the defined volume of interest was greater than 2.5 (SUVmax > 2. Read More

View Article and Full-Text PDF

Prediction efficacy of feature classification of solitary pulmonary nodules based on CT radiomics.

Eur J Radiol 2021 Mar 18:109667. Epub 2021 Mar 18.

Department of Radiology, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, 223300, China. Electronic address:

Objective: To investigate the relationship between CT radiomic features, pathological classification of pulmonary nodules, and evaluate the prediction effect of different stratified progressive radiomic models on the pathological classification of pulmonary nodules.

Methods: Altogether, 189 patients pathologically confirmed with pulmonary nodules from July 2017 to August 2019 who had complete data were enrolled, including 71 patients with benign nodules, 51 with malignant non-invasive nodules, and 67 with invasive nodules. Three CT radiomic models were established respectively. Read More

View Article and Full-Text PDF

CT-Guided Microcoil Localization of Small Peripheral Pulmonary Nodules to Direct Video-Assisted Thoracoscopic Resection without the Aid of Intraoperative Fluoroscopy.

Korean J Radiol 2021 Apr 1. Epub 2021 Apr 1.

Department of Radiology, China-Japan Friendship Hospital, Beijing, China.

Objective: To evaluate the feasibility, safety, and effectiveness of CT-guided microcoil localization of solitary pulmonary nodules (SPNs) for guiding video-assisted thoracoscopic surgery (VATS).

Materials And Methods: Between June 2016 and October 2019, 454 consecutive patients with 501 SPNs who received CT-guided microcoil localization before VATS in our institution were enrolled. The diameter of the nodules was 0. Read More

View Article and Full-Text PDF

Understanding the patient journey to diagnosis of lung cancer.

BMC Cancer 2021 Apr 14;21(1):402. Epub 2021 Apr 14.

Department of Health Policy and Management, School of Public Health and Tropical Medicine, Tulane University, 1440 Canal Street, Suite 1900, New Orleans, LA, 70112, USA.

Objective: This research describes the clinical pathway and characteristics of two cohorts of patients. The first cohort consists of patients with a confirmed diagnosis of lung cancer while the second consists of patients with a solitary pulmonary nodule (SPN) and no evidence of lung cancer. Linked data from an electronic medical record and the Louisiana Tumor Registry were used in this investigation. Read More

View Article and Full-Text PDF

Preoperative computed tomography-guided localization of lung nodules with needle placement: a series of cases.

Rev Col Bras Cir 2021 9;48:e20202890. Epub 2021 Apr 9.

- Hospital Nossa Senhora das Graças, Serviço de Cirurgia Torácica - Curitiba - PR - Brasil.

Objective: to report the preoperative localization of pulmonary nodules with the placement of a guidewire oriented by Computed Tomography.

Methods: the nodules were marked using a needle in the shape of a hook or another in the shape of a Q, guided by tomography. The choice of the location for the marking was the shortest distance from the chest wall to the nodule. Read More

View Article and Full-Text PDF

Prone position [F]FDG PET/CT to reduce respiratory motion artefacts in the evaluation of lung nodules.

Eur Radiol 2021 Apr 14. Epub 2021 Apr 14.

Department of Radiology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, 1 Singil-ro, Yeongdeungpo-gu, Seoul, 07441, Republic of Korea.

Objectives: 2-Deoxy-2-[F]fluoro-D-glucose ([F]FDG) positron-emission tomography/computed tomography (PET/CT) is widely used to evaluate lung nodules, although respiratory motion artefacts may occur. We investigated the value of prone position PET/CT (pPET/CT) in lung nodule evaluation compared with standard supine position PET/CT (sPET/CT).

Methods: We retrospectively reviewed 28 consecutive patients (20 men; age, 65. Read More

View Article and Full-Text PDF

Thyroid tuberculosis.

Indian J Tuberc 2021 Apr 12;68(2):272-278. Epub 2020 Sep 12.

Department of General Surgery, Dr Ram Manohar Lohia Hospital and Post Graduate, Institute of Medical Education and Research, New Delhi, India. Electronic address:

Thyroid tuberculosis is a rare disease. Its incidence is low even in countries where prevalence of pulmonary tuberculosis is high (0.1-0. Read More

View Article and Full-Text PDF

A solitary pulmonary nodule caused by Mycobacterium tuberculosis var. BCG after intravesical BCG treatment: a case report.

BMC Pulm Med 2021 Apr 7;21(1):115. Epub 2021 Apr 7.

Department of Respiratory Medicine and Infectious Diseases, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita, 879-5593, Japan.

Background: Intravesical instillation of bacillus Calmette-Guérin (BCG) as a treatment for superficial bladder cancer rarely causes pulmonary complications. While published cases have been pathologically characterized by multiple granulomatous lesions due to disseminated infection, no case presenting as a solitary pulmonary nodule has been reported.

Case Presentation: A man in his 70 s was treated with intravesical BCG for early-stage bladder cancer. Read More

View Article and Full-Text PDF

What Effect Do Pulmonary Micronodules Detected at Presentation in Patients with Osteosarcoma Have on 5-Year Overall Survival?

J Clin Med 2021 Mar 15;10(6). Epub 2021 Mar 15.

Rush University Medical College, Chicago, IL 60612, USA.

For osteosarcoma, staging criteria, prognosis estimates, and surgical recommendations have not yet changed to reflect increasingly sensitive computed tomography (CT) imaging. However, the frequent identification of micronodules (<5 mm) on presentation leaves clinicians in a difficult position regarding the need to biopsy, resect, or follow the lesions and whether to consider the patient metastatic or non-metastatic. Our objective was to compare the 5-year overall survival rates of patients with osteosarcoma with non-surgically resected lung micronodules on presentation to patients without micronodules to guide community oncologists faced with this common dilemma. Read More

View Article and Full-Text PDF

Is the Yedikule-solitary pulmonary nodule malignancy risk score sufficient to predict malignancy? An internal validation study.

Interact Cardiovasc Thorac Surg 2021 Apr 1. Epub 2021 Apr 1.

Department of Thoracic Surgery, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey.

Objectives: We aimed to develop a malignancy risk score model for solitary pulmonary nodules (SPNs) using the demographic, radiological and clinical characteristics of patients in our centre. The model was then internally validated for malignancy risk estimation.

Methods: A total of 270 consecutive patients who underwent surgery for SPN between June 2017 and May 2019 were retrospectively analysed. Read More

View Article and Full-Text PDF

Diagnostic accuracy of visual analysis versus dual time-point imaging with F-FDG PET/CT for the characterization of indeterminate pulmonary nodules with low uptake.

Rev Esp Med Nucl Imagen Mol 2021 May-Jun;40(3):155-160. Epub 2021 Mar 27.

Departamento de Medicina Nuclear, Clínica Universidad de Navarra, Pamplona, España.

Objective: To determine the accuracy of visual analysis and the retention index (RI) with dual-time point F-FDG PET/CT for the characterization of indeterminate pulmonary nodules (IPN) with low FDG uptake.

Materials And Methods: A retrospective analysis was performed on 43 patients (28 men, 64 ± 11 years old, range 36-83 years) referred for IPN characterization with F-FDG-PET/CT and maximum standard uptake value ≤ 2.5 at 60 minutes post-injection (SUV). Read More

View Article and Full-Text PDF

Lung adenocarcinoma mimicking hamartoma on CT.

Diagn Interv Imaging 2021 Mar 18. Epub 2021 Mar 18.

Department of Radiology, Hôpital Cochin, AP-HP centre, 75014 Paris, France; Université de Paris, 75006 Paris, France. Electronic address:

View Article and Full-Text PDF

Interobserver variability in Lung CT Screening Reporting and Data System categorisation in subsolid nodule-enriched lung cancer screening CTs.

Eur Radiol 2021 Mar 17. Epub 2021 Mar 17.

Department of Radiology, Seoul National University Bundang Hospital, 82, Gumi-ro 173beon-gil, Bundang-gu, Seongnam-si, Gyeongi-do, 13620, Korea.

Objectives: To assess interobserver agreement in Lung CT Screening Reporting and Data System (Lung-RADS) categorisation in subsolid nodule-enriched low-dose screening CTs.

Methods: A retrospective review of low-dose screening CT reports from 2013 to 2017 using keyword searches for subsolid nodules identified 54 baseline CT scans. With an additional 108 negative screening CT scans, a total of 162 CT scans were categorised according to the Lung-RADS by two fellowship-trained thoracic radiologists in consensus. Read More

View Article and Full-Text PDF

Ga-DOTATATE-avid pulmonary sclerosing pneumocytoma in a man of North African descent: Case report, imaging findings and pathology.

Clin Imaging 2021 Feb 27;77:175-179. Epub 2021 Feb 27.

Division of Cardiothoracic Imaging, Department of Radiology, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, United States of America.

Pulmonary sclerosing pneumocytoma (PSP) is a benign tumor originating from primitive respiratory epithelium which tends to present as an asymptomatic solitary lesion in the periphery of the lung. It primarily occurs in women, with a 5:1 ratio of female to male, and in East Asian populations. We describe a rare case of a gallium-68 (Ga)-DOTATATE avid PSP in a middle-aged man of North African ancestry. Read More

View Article and Full-Text PDF
February 2021

Analysis of pulmonary nodules caused by nontuberculous mycobacteriosis in 101 resected cases: multi-center retrospective study.

J Thorac Dis 2021 Feb;13(2):977-985

Osaka University Graduate School of Medicine, Department of General Thoracic Surgery, Suita-shi, Osaka, Japan.

Background: Solitary pulmonary nodules caused by nontuberculous mycobacteriosis are included as a category of pulmonary nontuberculous mycobacterium disease. Clinical characteristics, treatments and prognosis are not fully known because there are a few related reports.

Methods: This was a multi-center retrospective study of 101 cases diagnosed as solitary nodular type of nontuberculous mycobacteriosis from January 2000 to March 2017 that underwent resection at 9 related facilities belonging to the Thoracic Surgery Study Group of Osaka. Read More

View Article and Full-Text PDF
February 2021

Lung Cancer and Granuloma Identification Using a Deep Learning Model to Extract 3-Dimensional Radiomics Features in CT Imaging.

Clin Lung Cancer 2021 Feb 6. Epub 2021 Feb 6.

Department of Medical Imaging, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China. Electronic address:

Background: We aimed to evaluate a deep learning (DL) model combining perinodular and intranodular radiomics features and clinical features for preoperative differentiation of solitary granuloma nodules (GNs) from solid lung cancer nodules in patients with spiculation, lobulation, or pleural indentation on CT.

Patients And Methods: We retrospectively recruited 915 patients with solitary solid pulmonary nodules and suspicious signs of malignancy. Data including clinical characteristics and subjective CT findings were obtained. Read More

View Article and Full-Text PDF
February 2021

Case series of trans-thoracic nodule aspirate performed by interventional pulmonologists.

Respir Med Case Rep 2021 2;32:101362. Epub 2021 Feb 2.

Division of Pulmonary, Allergy & Critical Care Medicine, University of Massachusetts Medical School, Worcester, MA, USA.

Percutaneous interventional tissue sampling of pulmonary masses and lymphadenopathy is a means for diagnosis of thoracic malignancy. The user base that can perform this skill with ultrasound guidance is expanding. A retrospective cohort of fine needle aspiration and percutaneous core biopsies was identified to evaluate their safety and efficacy. Read More

View Article and Full-Text PDF
February 2021

An unusual case of reactivated latent pulmonary cryptococcal infection in a patient after short-term steroid and azathioprine therapy: a case report.

BMC Pulm Med 2021 Mar 4;21(1):76. Epub 2021 Mar 4.

Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Cheng-Kung Road, Neihu 114, Taipei, Taiwan.

Background: Cryptococcus is one of the major fungal pathogens infecting the lungs. Pulmonary cryptococcal infection is generally considered a community-acquired condition caused by inhalation of dust contaminated with fungal cells from the environment. Here, we report a case developing pulmonary cryptococcosis 3 months after hospital admission, which has rarely been reported before. Read More

View Article and Full-Text PDF

Intergroupe francophone de cancérologie thoracique, Société de pneumologie de langue française, and Société d'imagerie thoracique statement paper on lung cancer screening.

Diagn Interv Imaging 2021 Apr 26;102(4):199-211. Epub 2021 Feb 26.

Université de Paris, F-75006 Paris, France; Department of Radiology, Groupe Hospitalier Bichat-Claude-Bernard, Assistance publique-Hôpitaux de Paris, 75018 Paris, France.

Following the American National Lung Screening Trial results in 2011 a consortium of French experts met to edit a statement. Recent results of other randomized trials gave the opportunity for our group to meet again in order to edit updated guidelines. After literature review, we provide here a new update on lung cancer screening in France. Read More

View Article and Full-Text PDF

Preliminary Investigation and Imaging Analysis of Early Lung Cancer Screening Among Petroleum Workers in North China.

Cancer Invest 2021 Apr 1;39(4):321-332. Epub 2021 Mar 1.

Department of Radiology, Huabei Petroleum General Hospital, Hebei,China.

Background: The detection rate of lung nodules has increased significantly among petroleum workers in North China since the low-dose CT (LDCT) screening has been widely carried out. What's more, the number of confirmed early lung cancers is increasing continuously. Therefore, a great deal of concern for the high risk of lung cancer has been shown among petroleum workers. Read More

View Article and Full-Text PDF

Lung cancer screening: French radiologists should prepare for it.

Diagn Interv Imaging 2021 Apr 25;102(4):197-198. Epub 2021 Feb 25.

Department of Radiology, Hôpital Marie Lannelongue, Institut d'Oncologie Thoracique, Paris-Saclay University, 92350 Le Plessis-Robinson, France.

View Article and Full-Text PDF

Development and Validation of Machine Learning-based Model for the Prediction of Malignancy in Multiple Pulmonary Nodules: Analysis from Multicentric Cohorts.

Clin Cancer Res 2021 Apr 24;27(8):2255-2265. Epub 2021 Feb 24.

Department of Thoracic Surgery, Peking University People's Hospital, Beijing, China.

Purpose: Nodule evaluation is challenging and critical to diagnose multiple pulmonary nodules (MPNs). We aimed to develop and validate a machine learning-based model to estimate the malignant probability of MPNs to guide decision-making.

Experimental Design: A boosted ensemble algorithm (XGBoost) was used to predict malignancy using the clinicoradiologic variables of 1,739 nodules from 520 patients with MPNs at a Chinese center. Read More

View Article and Full-Text PDF

Comparison of Radiomic Models Based on Low-Dose and Standard-Dose CT for Prediction of Adenocarcinomas and Benign Lesions in Solid Pulmonary Nodules.

Front Oncol 2020 2;10:634298. Epub 2021 Feb 2.

Department of Radiology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Objectives: This study aimed to develop radiomic models based on low-dose CT (LDCT) and standard-dose CT to distinguish adenocarcinomas from benign lesions in patients with solid solitary pulmonary nodules and compare the performance among these radiomic models and Lung CT Screening Reporting and Data System (Lung-RADS). The reproducibility of radiomic features between LDCT and standard-dose CT were also evaluated.

Methods: A total of 141 consecutive pathologically confirmed solid solitary pulmonary nodules were enrolled including 50 adenocarcinomas and 48 benign nodules in primary cohort and 22 adenocarcinomas and 21 benign nodules in validation cohort. Read More

View Article and Full-Text PDF
February 2021