4,501 results match your criteria Solitary Pulmonary Nodule


Prevalence of pulmonary nodules in dogs with malignant neoplasia as determined by CT.

Vet Radiol Ultrasound 2019 Feb 19. Epub 2019 Feb 19.

Department of Clinical Sciences and Services, The Royal Veterinary College, Hertfordshire, United Kingdom.

In order to estimate the prevalence of pulmonary nodules in dogs with nonpulmonary malignant neoplasia, medical record descriptions of CT findings in dogs diagnosed with nonpulmonary malignant neoplasia were reviewed retrospectively. A total of 536 dogs were sampled from a single hospital. For malignant neoplasms with >10 affected individuals, prevalence of multiple pulmonary nodules at first CT was hemangiosarcoma 24 of 58 (41%), osteosarcoma 14 of 55 (26%), carcinoma 20 of 80 (25%), histiocytic sarcoma five of twenty-one (24%), soft tissue sarcoma 13 of 57 (23%), adenocarcinoma 11 of 60 (18%), melanoma five of thirty-seven (14%), lymphoma 10 of 76 (13%), mast cell tumor two of forty-seven (4%), and squamous cell carcinoma zero of seventeen (0%). Read More

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http://dx.doi.org/10.1111/vru.12723DOI Listing
February 2019

Pulmonary histoplasmoma: a disguised malady.

Autops Case Rep 2018 Oct-Dec;8(4):e2018065. Epub 2018 Dec 5.

Universidade de São Paulo, School of Medicine, Department of Surgery. São Paulo, SP, Brazil.

Histoplasmosis is a mycosis caused by the dimorphic fungus, , which is transmitted via dust and aerosols. Lung involvement is the most common, with a varied clinical presentation. Although it is not the only source of infection, is frequently found in bat guano, which is the reason why it is highly prevalent among caving practitioners. Read More

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http://dx.doi.org/10.4322/acr.2018.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360832PMC
December 2018

Recurrent Metastatic Eccrine Porocarcinoma: A Case Report and Review of the Literature.

Am J Case Rep 2019 Feb 11;20:179-183. Epub 2019 Feb 11.

Division of Hematology and Oncology, Bronx Care Health System, Affiliated with Icahn School of Medicine at Mount Sinai, Bronx, NY, USA.

BACKGROUND Eccrine porocarcinoma, or malignant eccrine poroma, is a rare primary skin tumor that develops in the sixth and seventh decades of life, and can present as a painless and solitary nodule. Histopathology is required to confirm the diagnosis. A rare case is presented of metastatic eccrine porocarcinoma, occurring four years after surgical excision of the primary scalp tumor, and includes a review of the literature. Read More

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http://dx.doi.org/10.12659/AJCR.913440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380207PMC
February 2019
2 Reads

Pulmonary adenofibroma in a sika deer.

J Vet Med Sci 2019 Feb 5. Epub 2019 Feb 5.

Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University.

A solitary firm nodule was found in the lung of a sika deer (Cervus nippon yesoensis). Histologically, it was a biphasic lesion composed of epithelial and stromal cell elements and exhibited a leaf-like growth pattern. The epithelial cells were immunohistochemically positive for pancytokeratin, cytokeratin 7, napsin A, and thyroid transcription factor-1, and the stromal cells were positive for vimentin and partially positive for desmin and α-smooth muscle actin. Read More

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http://dx.doi.org/10.1292/jvms.18-0691DOI Listing
February 2019
1 Read

Solitary pulmonary nodule: An interesting clinical mimicry of pulmonary tuberculosis.

Med J Armed Forces India 2019 Jan 15;75(1):115-118. Epub 2018 Oct 15.

Assistant Professor (Lab Sciences & Molecular Med), Army Hospital (R&R), New Delhi 110010, India.

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http://dx.doi.org/10.1016/j.mjafi.2018.07.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349671PMC
January 2019
2 Reads

Changes in quantitative parameters of pulmonary nonsolid nodule induced by lung inflation according to paired inspiratory and expiratory computed tomography imaging.

Eur Radiol 2019 Jan 28. Epub 2019 Jan 28.

Department of Radiology, Changzheng Hospital, Second Military Medical University, No. 415 Fengyang Road, Shanghai, 200003, China.

Objective: To evaluate quantitative parameters of nonsolid nodules on paired inspiratory and expiratory computed tomography (CT) and to examine whether these parameters are sensitive to lung inflation reflected by lung volume.

Methods: Thirty-three patients with 41 nonsolid nodules were included in this prospective study. Paired inspiratory and low-dose respiratory plain chest CT were performed. Read More

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http://link.springer.com/10.1007/s00330-018-5970-5
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http://dx.doi.org/10.1007/s00330-018-5970-5DOI Listing
January 2019
10 Reads

Invasive Pulmonary Adenocarcinoma with Lepidic Growth Pattern in a Pregnant Patient.

Case Rep Oncol 2018 Sep-Dec;11(3):822-834. Epub 2018 Dec 11.

University of Groningen, University Medical Center Groningen, Department of Neurology, Groningen, The Netherlands.

Among the differential diagnoses that should be considered in acute respiratory failure (ARF) are infectious processes, autoimmune diseases, interstitial pulmonary fibrosis, and pulmonary neoplasia. Timely diagnosis of lung neoplasia is complicated in the early stages. An opportune diagnosis, as well as the specific treatment, decrease mortality. Read More

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http://dx.doi.org/10.1159/000495460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341323PMC
December 2018
6 Reads

[Treatment principle and surgical technique of pulmonary ground glass nodules].

Zhonghua Zhong Liu Za Zhi 2019 Jan;41(1):6-9

Department of thoracic surgery, Zhongshan hospital, Fudan university, Shanghai 200032, China.

Pulmonary ground glass nodule (GGN) is a term of radiological manifestation, which may be malignant or benign. GGN's imaging performance is diverse, and the management for pulmonary GGN remains controversial. Numerous clinical studies have clarified the safety of GGN follow-up and longer follow-up intervals, stricter surgical or biopsy indications are recommended. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2019.01.002DOI Listing
January 2019
1 Read

[Combination of CT mulitplane 3D reconstruction, radial endobronchial ultrasound and rapid on-site evaluation for diagnosing peripheral solitary pulmonary nodules].

Zhonghua Yi Xue Za Zhi 2019 Jan;99(2):93-98

Department of Respiratory Medicine, General Hospital of Eastern Theater Command, the Institute of Respiratory Diseases of Nanjing University, Nanjing 210002, China.

To evaluate the diagnostic efficiency of combination of CT multiplane 3D reconstruction (CT-3DR), radial endobronchial ultrasound (R-EBUS), and rapid on-site evaluation (ROSE) for peripheral solitary pulmonary nodules (SPN). A total of 176 patients with peripheral solitary pulmonary nodule were included from the Nanjing Chest Hospital from March 2016 to March 2017. According to different methods, all the patients were divided into four groups: EG (i. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.02.004DOI Listing
January 2019
6 Reads

False positive reduction in pulmonary nodule classification using 3D texture and edge feature in CT images.

Technol Health Care 2019 Jan 9. Epub 2019 Jan 9.

Background: Pulmonary nodule detection can significantly influence the early diagnosis of lung cancer while is confused by false positives.

Objective: In this study, we focus on the false positive reduction and present a method for accurate and rapid detection of pulmonary nodule from suspective regions with 3D texture and edge feature.

Methods: This work mainly consists of four modules. Read More

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http://dx.doi.org/10.3233/THC-181565DOI Listing
January 2019
2 Reads

Is 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography useful to discriminate metachronous lung cancer from metastasis in patients with oncological history?

Q J Nucl Med Mol Imaging 2019 Jan 17. Epub 2019 Jan 17.

Nuclear Medicine Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy -

Background: Solitary pulmonary nodules detected during follow-up in patients with previous cancer history have a high probability of malignancy being either a metachronous lung cancer or a metastasis. This distinction represents a crucial issue in the perspective of "personalized medicine", implying different treatments and prognosis. Aim - to evaluate the role of 18F-Fluorodeoxyglucose (18F-FDG) Positron Emission Tomography/Computed Tomography (PET/CT) in distinguishing whether solitary pulmonary nodules are metachronous cancers or metastases and the relationship between the nodule's characteristics and their nature. Read More

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http://dx.doi.org/10.23736/S1824-4785.19.03140-6DOI Listing
January 2019
1 Read

PET Counting Response Variability Depending on Tumor Location, Activity, and Patient Obesity: A Feasibility Study of Solitary Pulmonary Nodule Using Monte Carlo.

IEEE Trans Med Imaging 2019 Jan 10. Epub 2019 Jan 10.

We aim to investigate the counting response variations of Positron Emission Tomography (PET) scanners with different detector configurations in the presence of Solitary Pulmonary Nodule (SPN). Using experimentally validated Monte Carlo simulations, the counting performance of four different scanner models with varying tumor activity, location, and patient obesity is represented using NECR (Noise Equivalent Count Rate). NECR is a well-established quantitative metric which has positive correlation with clinically perceived image quality. Read More

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http://dx.doi.org/10.1109/TMI.2019.2891578DOI Listing
January 2019
1 Read

Visual assessment of calcification in solitary pulmonary nodules on chest radiography: correlation with volumetric quantification of calcification.

Eur Radiol 2019 Jan 7. Epub 2019 Jan 7.

Department of Radiology, Ajou University Medical Center, 164 Worldcup Road, Yeongtong-gu, Suwon, 16499, South Korea.

Purpose: To assess the ability of digital chest radiography (CXR) to reveal calcification in solitary pulmonary nodules (SPNs), and to examine the correlation between a visual assessment and volumetric quantification of the calcification.

Materials And Methods: This study was a retrospective review of 220 SPNs identified by both CXR and chest CT. Eleven observers did blind review of the CXR images and scored nodule calcification on a confidence scale of 1 to 5. Read More

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http://dx.doi.org/10.1007/s00330-018-5883-3DOI Listing
January 2019
2 Reads

Clinical application of planar puncture template-assisted computed tomography-guided percutaneous biopsy for small pulmonary nodules.

J Cancer Res Ther 2018 ;14(7):1632-1637

Department of Radiation Oncology, Peking University Third Hospital, Beijing; China Northern Radioactive Brachytherapy Group, Tangshan People's Hospital, Tangshan, Hebei, China.

Aims: The aims of this study were to evaluate the clinical application of planar puncture template (PPT) in computed tomography (CT)-guided percutaneous needle lung biopsy.

Subjects And Methods: A total of 56 patients with small pulmonary nodules who received CT-guided percutaneous lung biopsy assisted by PPT were included in the study. Five steps were included in the study: fixing position, CT scanning and designing needle pathway, installing navigation system and template, puncturing fixation needle, and performing biopsy needle insertion and biopsy. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_1017_17DOI Listing
February 2019
2 Reads

Folate-receptor-positive circulating tumor cells as an efficacious biomarker for the diagnosis of small pulmonary nodules.

J Cancer Res Ther 2018 ;14(7):1620-1626

Department of Thoracic Surgery, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.

Objective: The objective of this study is to investigate the clinical significance of folate-receptor-positive circulating tumor cells (FR+CTC) for the diagnosis of lung cancer, especially in early-stage patients.

Materials And Methods: A total of 72 lung cancer patients, including 31 with stage I diseases and two with stage 0 diseases, were enrolled in this study. Twenty-four patients with benign lung diseases and two healthy volunteers served as the control group. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_905_17DOI Listing
February 2019

Application value of coaxial biopsy system in needle cutting biopsy for focal ground glass-like density nodule.

J Cancer Res Ther 2018 ;14(7):1509-1514

Department of Radiology, The Affiliated Hospital of Qingdao University, 266101, Shandong, China.

Objective: The objective of the study is to evaluate the clinical efficacy and accuracy of coaxial biopsy puncture applied to make a diagnosis in 76 patients diagnosed with focal ground-glass density nodule (GGN).

Materials And Methods: In total, 76 patients were diagnosed with pure GGN (pGGN), 24 males and 52 females, aged (52 ± 1.2) years on average (range: 47-72 years). Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_382_18DOI Listing
February 2019
1 Read

Primary Pulmonary Chordoid Meningioma.

Korean J Thorac Cardiovasc Surg 2018 Dec 5;51(6):410-414. Epub 2018 Dec 5.

Department of Pathology, Hanyang University Seoul Hospital, Hanyang University College of Medicine.

Primary pulmonary meningioma is a rare disease, and chordoid meningioma is an uncommon variant of meningioma in the central nervous system (CNS) with a high recurrence rate. We report a case of primary pulmonary chordoid meningioma that presented as a solitary pulmonary nodule (SPN). The SPN was resected by thoracoscopic wedge resection and was revealed to have characteristics of chordoid meningioma. Read More

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http://dx.doi.org/10.5090/kjtcs.2018.51.6.410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301318PMC
December 2018
2 Reads

Can spectral computed tomography imaging improve the differentiation between malignant and benign pulmonary lesions manifesting as solitary pure ground glass, mixed ground glass, and solid nodules?

Thorac Cancer 2019 Feb 23;10(2):234-242. Epub 2018 Dec 23.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiology, Peking University Cancer Hospital & Institute, Beijing, China.

Background: This study quantitatively assessed the efficacy of spectral computed tomography (CT) imaging parameters for differentiating the malignancy and benignity of solitary pulmonary nodules (SPNs) manifesting as ground glass nodules (GGNs) and solid nodules (SNs).

Methods: The study included 114 patients with SPNs (61 GGNs, and 53 SNs) who underwent CT plain and enhanced scans in the arterial (a) and venous (v) phases using the spectral imaging mode. The spectral CT imaging parameters included: iodine concentrations (IC) of lesions in the arterial (ICLa) and venous (ICLv) phases; normalized IC (NICa/NICv, normalized to the IC in the aorta); the slope of the spectral Hounsfield unit (HU) curve (λHUa/λHUv); and monochromatic CT number (CT40keVa/v, CT70keVa/v) enhancement on 40 and 70 keV images. Read More

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http://dx.doi.org/10.1111/1759-7714.12937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360238PMC
February 2019
1 Read

Update on radioguided surgery: from international consensus on sentinel node in head and neck cancer to the advances on gynaecological tumors and localization of non-palpable lesions.

Rev Esp Med Nucl Imagen Mol 2018 Dec 19. Epub 2018 Dec 19.

Servicio de Medicina Nuclear, Complejo Hospitalario de Navarra , Pamplona, Navarra, España. Electronic address:

The aim of this review is to provide an updated perspective on different fields of radioguided surgery. With reference to the sentinel lymph node biopsy in oral squamous cell carcinoma, we present the results of the interactive debate held at the recent Congress of our specialty about the more relevant aspects of the London Consensus. Drainage peculiarities and indications according to the current guidelines on gynaecological tumours, endometrial and cervical cancer, are detailed and new scenarios for nuclear medicine physicians are presented; robotic surgery and hybrid tracers, for instance. Read More

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http://dx.doi.org/10.1016/j.remn.2018.10.007DOI Listing
December 2018
1 Read

Erythroderma and a Pulmonary Nodule.

N Engl J Med 2018 Dec;379(24):e41

University Hospital of Parma, Parma, Italy

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http://dx.doi.org/10.1056/NEJMicm1802572DOI Listing
December 2018
1 Read

Solitary pulmonary metastasis from a gingival cancer of 36 years ago: A case report.

Int J Surg Case Rep 2018 24;53:436-440. Epub 2018 Nov 24.

Departments of General Thoracic Surgery, Seirei Hamamatsu General Hospital, Japan.

Introduction: Unlike a squamous cell carcinoma (SqCC), an adenoid cystic carcinoma (ACC) is an uncommon histology of all head and neck cancers. The clinical significance of a pulmonary metastasectomy differs greatly between these two types of cancers. A solitary pulmonary nodule in a patient with a history of both these different malignancies is a diagnostic and therapeutic challenge. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.11.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262786PMC
November 2018
1 Read

[Mimics of lung cancer].

Radiologe 2019 Jan;59(1):57-70

Institut für Röntgendiagnostik, Otto-Wagner-Spital, Baumgartner Höhe 1, 1140, Wien, Österreich.

Lung cancer is a histologically, immunologically and therefore morphologically and functionally very heterogeneous group of neoplasms with the highest cancer mortality worldwide. Therefore, the range of diseases mimicking lung cancer is also very broad and includes congenital, infectious and inflammatory changes as well as other benign space-occupying lesions and other primary and secondary pulmonary neoplasms. The difficulty in radiology lies in the ability to diagnose lung cancer with a high degree of certainty. Read More

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http://dx.doi.org/10.1007/s00117-018-0476-3DOI Listing
January 2019

F-FDG PET/CT diagnostic performance in solitary and multiple pulmonary nodules detected in patients with previous cancer history: reports of 182 nodules.

Eur J Nucl Med Mol Imaging 2019 02 8;46(2):429-436. Epub 2018 Dec 8.

Nuclear Medicine Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Francesco Vito, 1, 00168, Roma, Italia.

Purpose: In oncological patients, F-FDG PET/CT performance for pulmonary nodules' characterization is not well-established. Thus, the purpose of this study was to evaluate the F-FDG PET/CT diagnostic performance in pulmonary nodules detected during follow-up in oncological patients and the relationship between malignancy and nodules' characteristics.

Methods: We retrospectively evaluated 182 pulmonary nodules (121 solitary, 61 multiple; mean size = 16. Read More

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http://dx.doi.org/10.1007/s00259-018-4226-6DOI Listing
February 2019
4 Reads

[Comparative analysis of computed tomography texture features between pulmonary inflammatory nodules and lung cancer].

Zhonghua Zhong Liu Za Zhi 2018 Nov;40(11):847-850

Department of Radiology, Shanxi Dayi Hospital, Taiyuan 030032, China.

To investigate the value of computed tomography (CT) texture analysis in differential diagnosis of inflammatory and malignant pulmonary nodules. The image data of 54 patients with lung cancer and 36 patients with pulmonary inflammatory nodules were retrospectively collected in our hospital. All the patients received chest CT scan. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2018.11.010DOI Listing
November 2018
9 Reads

CT-based radiomics signature for differentiating solitary granulomatous nodules from solid lung adenocarcinoma.

Lung Cancer 2018 Nov 17;125:109-114. Epub 2018 Sep 17.

Department of Radiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, State Key Laboratory of Respiratory Diseases, Guangzhou, China. Electronic address:

Objectives: Pulmonary granulomatous nodule (GN) with spiculated or lobulated appearance are indistinguishable from solid lung adenocarcinoma (SADC) based on CT morphological features, and partial false-positive findings on PET/CT. The objective of this study was to investigate the ability of quantitative CT radiomics for preoperatively differentiating solitary atypical GN from SADC.

Methods: 302 eligible patients (SADC = 209, GN = 93) were evaluated in this retrospective study and were divided into training (n = 211) and validation cohorts (n = 91). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01695002183057
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http://dx.doi.org/10.1016/j.lungcan.2018.09.013DOI Listing
November 2018
11 Reads

Incidental Pulmonary Nodules Detected on CT Images.

JAMA 2018 Dec;320(21):2260-2261

University of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1001/jama.2018.16336DOI Listing
December 2018
1 Read

Outcome of untreated lung nodules with histological but no microbiological evidence of tuberculosis.

BMC Infect Dis 2018 Oct 23;18(1):530. Epub 2018 Oct 23.

Division of Thoracic Surgery, Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

Background: The outcome of lung nodule(s) with histopathological findings suggestive of tuberculosis (TB) but lack of microbiologic confirmation remains unclear. Whether these patients require anti-TB treatment remains unknown. The aim of the study was to compare the risk of active TB within 4 years in untreated patients with histological findings but no microbiological evidences suggestive of TB. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3442-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199800PMC
October 2018
7 Reads

Comparison of Various Parameters of DWI in Distinguishing Solitary Pulmonary Nodules.

Curr Med Sci 2018 Oct 20;38(5):920-924. Epub 2018 Oct 20.

Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

In order to prospectively assess various parameters of diffusion weighted imaging (DWI) in differential diagnosis of benign and malignant solitary pulmonary nodules (SPNs), 58 patients (40 men and 18 women, and mean age of 48.1±10.4 years old) with SPNs undergoing conventional MR, DWI using b=500 s/mm on a 1. Read More

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http://link.springer.com/10.1007/s11596-018-1963-5
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http://dx.doi.org/10.1007/s11596-018-1963-5DOI Listing
October 2018
19 Reads

Single-view 2D CNNs with fully automatic non-nodule categorization for false positive reduction in pulmonary nodule detection.

Comput Methods Programs Biomed 2018 Oct 31;165:215-224. Epub 2018 Aug 31.

School of Electrical Engineering, Korea Advanced Institute of Science and Technology, Republic of Korea. Electronic address:

Background And Objective: In pulmonary nodule detection, the first stage, candidate detection, aims to detect suspicious pulmonary nodules. However, detected candidates include many false positives and thus in the following stage, false positive reduction, such false positives are reliably reduced. Note that this task is challenging due to 1) the imbalance between the numbers of nodules and non-nodules and 2) the intra-class diversity of non-nodules. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01692607183074
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http://dx.doi.org/10.1016/j.cmpb.2018.08.012DOI Listing
October 2018
9 Reads

The "solid" component within subsolid nodules: imaging definition, display, and correlation with invasiveness of lung adenocarcinoma, a comparison of CT histograms and subjective evaluation.

Eur Radiol 2018 Oct 15. Epub 2018 Oct 15.

Department of Radiology, Changzheng Hospital, Second Military Medical University, No. 415 Fengyang Road, Shanghai, 200003, China.

Objective: To validate three proposed definitions of the "solid" component of subsolid nodules, as compared to CT histograms and the use of different window settings, for discriminating the invasiveness of adenocarcinomas in a manner that facilitates routine clinical assessment.

Methods: We retrospectively analyzed 328 pathologically confirmed lung adenocarcinomas, manifesting as subsolid nodules. Three-dimensional CT histograms were generated by setting 11 CT attenuation intervals from - 400 to 50 HU, at 50 HU intervals, and the voxel percentage within each CT attenuation interval was generated automatically. Read More

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http://link.springer.com/10.1007/s00330-018-5778-3
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http://dx.doi.org/10.1007/s00330-018-5778-3DOI Listing
October 2018
10 Reads
4.014 Impact Factor

Clinical prediction of solitary pulmonary nodule after a curative resection for gastric cancer.

Jpn J Clin Oncol 2018 Dec;48(12):1083-1087

Division of Thoracic Surgery, National Cancer Center Hospital East, Chiba, Japan.

Background: Gastric cancer metastasis to the lung can rarely manifest as solitary pulmonary nodule. The surgical strategies are different between metastasis from gastric cancer and primary lung cancer; therefore, the clinical prediction of solitary pulmonary nodule is important.

Methods: Between September 2006 and September 2016, 38 patients with a history of curative resection for gastric cancer who subsequently underwent lung resection for solitary pulmonary nodule at our institution were evaluated. Read More

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https://academic.oup.com/jjco/advance-article/doi/10.1093/jj
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http://dx.doi.org/10.1093/jjco/hyy146DOI Listing
December 2018
10 Reads

Primary pulmonary meningioma mimicking lung metastatic tumor: a case report.

J Cardiothorac Surg 2018 Oct 1;13(1):99. Epub 2018 Oct 1.

Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.

Background: Primary pulmonary meningioma (PPM) is an extremely rare benign tumor. Previous reports indicated that CT features of PPM are single, solid, well-demarcated, homogeneous mass. In this study, we report a case of PPM with atypical CT features. Read More

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http://dx.doi.org/10.1186/s13019-018-0787-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167906PMC
October 2018
5 Reads

Solitary pulmonary capillary hemangioma: An under-recognized pulmonary lesion mimicking early lung cancer on computed tomography images.

Lung Cancer 2018 Oct 11;124:227-232. Epub 2018 Aug 11.

Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

Objectives: Solitary pulmonary capillary hemangioma (SPCH) is a rare lung tumor typically presenting as pure or part-solid ground-glass nodules (GGNs) on computed tomography (CT), which clinically resembles early lung cancer.

Materials And Methods: In addition to 10 recently diagnosed patients with SPCH, 71 benign lung nodules that were surgically resected between January 2013 and December 2017 were reviewed by thoracic pathologists to identify any previously unrecognized SPCH cases. Finally, 6 tumors (8. Read More

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http://dx.doi.org/10.1016/j.lungcan.2018.08.009DOI Listing
October 2018
3 Reads

A new bronchoscopic catheter for the transbronchial ablation of pulmonary nodules.

Lung Cancer 2018 Oct 26;124:125-129. Epub 2018 Jul 26.

Translational Lung Research Center Heidelberg (TLRCH), Heidelberg, Member of the German Center for Lung Research (DZL), Germany; Department of Pneumology and Critical Care Medicine, Thoraxklinik, Heidelberg University Hospital, Roentgenstrasse 1, 69126, Heidelberg, BW, Germany.

Objectives: With the objective of simultaneous bronchoscopic biopsy and ablation of malignant solitary pulmonary nodules, we have developed a flexible monopolar radiofrequency (RF) catheter that can be deployed through the working channel of most bronchoscopes.

Materials And Methods: Fresh tumor specimens were heated in a water bath to 37 °C, and the RF catheter was inserted into the tumors within the specimen. Temperature sensors were positioned 3 mm, 5 mm and 7 mm from the electrode to measure the temperature of the surrounding tissue every 1 s. Read More

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http://dx.doi.org/10.1016/j.lungcan.2018.07.038DOI Listing
October 2018
14 Reads

Influence of radiologic expertise in detecting lung tumors on chest radiographs.

Diagn Interv Imaging 2019 Feb 25;100(2):95-107. Epub 2018 Sep 25.

University of Tsukuba, Faculty of Medicine, Department of Diagnostic and Interventional Radiology, Ibaraki, Japan.

Purpose: To analyze the influence of radiologic expertise in detecting lung tumors on chest radiographs.

Materials And Methods: We retrieved posteroanterior chest radiographs and CT examination obtained from 283 patients with solitary primary malignant lung tumors who underwent surgical resection. There were 176 men and 107 women with a mean age of 67. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22115684183022
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http://dx.doi.org/10.1016/j.diii.2018.08.015DOI Listing
February 2019
6 Reads

The clincopathological variables to differentiate the nature of isolated pulmonary nodules in patients who received curative surgery for colorectal cancer.

Asian J Surg 2019 Feb 25;42(2):425-432. Epub 2018 Sep 25.

Division of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Center for Biomarkers and Biotech Drugs, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:

Background: In colorectal cancer (CRC) patients, pulmonary nodules are usually considered lung metastases (LM). However, approximately 10% of LM is presented as a solitary pulmonary nodule which mimics primary lung cancer (PLC). This study aims to determine the distinguishing characteristics of the two pulmonary nodule types during postoperative surveillance of CRC patients. Read More

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http://dx.doi.org/10.1016/j.asjsur.2018.08.002DOI Listing
February 2019
12 Reads

CT characterization of different pathological types of subcentimeter pulmonary ground-glass nodular lesions.

Br J Radiol 2019 Feb 9;92(1094):20180204. Epub 2018 Oct 9.

1 Department of Radiology, Huadong Hospital affiliated with Fudan University , Shanghai , China.

Objective: To explore the CT characteristics of small lung nodules and improve the diagnosis of pulmonary ground-glass nodules less than 10  mm in size.

Methods: We retrospectively analyzed CT images of 161 pulmonary nodules (less than 10  mm in size) with spiculation, lobulation, vacuoles, and pleural indentation and compared these images with pathological results or follow-up CT images. The relationships between the ground-glass nodules (GGNs) and blood vessels were observed. Read More

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https://www.birpublications.org/doi/10.1259/bjr.20180204
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http://dx.doi.org/10.1259/bjr.20180204DOI Listing
February 2019
3 Reads

Differentiating between malignant and benign solid solitary pulmonary lesions: are intravoxel incoherent motion and diffusion kurtosis imaging superior to conventional diffusion-weighted imaging?

Eur Radiol 2019 Mar 25;29(3):1607-1615. Epub 2018 Sep 25.

Department of Radiology, The First Affiliated Hospital of Guangzhou Medical University, Yanjiangxilu No 151., Guangzhou, China.

Objective: To quantitatively compare the diagnostic values of various diffusion parameters obtained from mono- and biexponential diffusion-weighted imaging (DWI) models and diffusion kurtosis imaging (DKI) in differentiating between benign and malignant solitary pulmonary lesions (SPLs).

Methods: Multiple b-value DWIs and DKIs were performed in 89 patients with SPL by using a 3-T magnetic resonance (MR) imaging unit. The apparent diffusion coefficient (ADC) of various b-value sets, true diffusivity (D), pseudo-diffusion coefficient (D*), perfusion fraction (f), apparent diffusional kurtosis (K), and kurtosis-corrected diffusion coefficient (D) were calculated and compared between the malignant and benign groups using a Mann-Whitney U test. Read More

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http://dx.doi.org/10.1007/s00330-018-5714-6DOI Listing
March 2019
16 Reads

Thoracoscopic Lung Lobectomy for a Lung Cancer Patient with Situs Inversus Totalis.

J UOEH 2018;40(3):237-241

Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Japan.

Situs inversus totalis is a rare clinical condition that represents a complete mirror image of the normal arrangement of the thoracic and abdominal viscera. There are very few reported cases of lung cancer patients with situs inversus totalis, but this condition requires particular care during surgery. A 61-year-old woman presented to our hospital with an abnormal shadow on chest radiography. Read More

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http://dx.doi.org/10.7888/juoeh.40.237DOI Listing
January 2018
2 Reads

Electromagnetic Navigation Bronchoscopy: Where Are We Now? Five Years of a Single-Center Experience.

Lung 2018 Sep 12. Epub 2018 Sep 12.

Division of Respiratory Medicine, Medical Department, University of Piemonte Orientale, AOU Maggiore della Carità di Novara, C.so Mazzini 18, 28100, Novara, Italy.

Introduction: Electromagnetic navigation (ENB) is a guidance tool used in the diagnosis of solitary pulmonary nodules (SPNs) and masses. Its diagnostic yield is highly variable (38-71%) and a recent study has put in doubt the role of ENB in sampling SPNs in a real-life setting. The aim of this study is to describe the 5-year experience of our center with ENB, analyzing the population, possible confounding factors, and the diagnostic yield and accuracy of this technique. Read More

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http://link.springer.com/10.1007/s00408-018-0161-3
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http://dx.doi.org/10.1007/s00408-018-0161-3DOI Listing
September 2018
4 Reads

Alpha-fetoprotein (AFP) as tumor marker in a patient with urothelial cancer with exceptional response to anti-PD-1 therapy and an escape lesion mimic.

J Immunother Cancer 2018 Sep 12;6(1):89. Epub 2018 Sep 12.

Division of Hematology and Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA.

The development of a new lesion in a patient with a complete remission to anti-PD-1 therapy is highly concerning for a drug resistant escape lesion. Here, we present a case of a 62-year-old patient with chemotherapy-resistant metastatic urothelial cancer who had a complete remission to pembrolizumab. The patient's disease burden tracked closely to serum levels of alpha-fetoprotein (AFP) expressed by the tumor and served as an accurate tumor marker. Read More

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https://jitc.biomedcentral.com/articles/10.1186/s40425-018-0
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http://dx.doi.org/10.1186/s40425-018-0394-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134551PMC
September 2018
15 Reads

Invited Commentary on "Updated Fleischner Society Guidelines for Managing Incidental Pulmonary Nodules".

Authors:
Ann N Leung

Radiographics 2018 Sep-Oct;38(5):1350-1351

Department of Radiology, Stanford University Medical Center Stanford, California.

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http://dx.doi.org/10.1148/rg.2018180182DOI Listing
September 2018
2 Reads

Updated Fleischner Society Guidelines for Managing Incidental Pulmonary Nodules: Common Questions and Challenging Scenarios.

Radiographics 2018 Sep-Oct;38(5):1337-1350

From the Department of Radiology and Medical Imaging, University of Virginia Medical Center, 1215 Lee St, PO Box 800170, Charlottesville, VA 22908 (J.B.); and Department of Radiology, University of Chicago, Chicago, Ill (L.L., J.H.C.).

The new guidelines for managing incidental pulmonary nodules published by the Fleischner Society in 2017 reflect an improved understanding of the risk factors and biologic features of lung cancer. Specific topics emphasized in the updated guidelines include a new threshold size for follow-up, the importance of the morphologic features of nodules, accurate nodule measurements, recognition of subsolid components, understanding interval growth or change in nodule morphology, and knowledge of patient risk factors. The updated guidelines enable greater personal flexibility in the decision-making process and encourage individualized management of pulmonary nodules. Read More

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http://pubs.rsna.org/doi/10.1148/rg.2018180017
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http://dx.doi.org/10.1148/rg.2018180017DOI Listing
December 2018
3 Reads

[Solitary Pulmonary Metastasis from Carcinoma of the Ampulla of Vater after Pancreatoduodenectomy;Report of a Case].

Kyobu Geka 2018 09;71(9):708-711

Department of General Thoracic Surgery, Japanese Red Cross Kobe Hospital/Kobe University, Kobe, Japan.

A 74-year-old woman had underwent pancreatoduodenectomy for a carcinoma of the ampulla of Vater. After 3 years of the operation, chest computed tomography (CT) scan showed a solitary nodule in the right posterior segment (S2). Under the diagnosis of solitary pulmonary metastasis, we performed wedge resection for the right S2 lesion under video-assisted thoracic surgery (VATS). Read More

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September 2018
2 Reads

Circulating tumor cell levels and carcinoembryonic antigen: An improved diagnostic method for lung adenocarcinoma.

Thorac Cancer 2018 Nov 4;9(11):1413-1420. Epub 2018 Sep 4.

Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Medical College of Soochow University, Suzhou, China.

Background: The aim of this study was to determine a correlation between benign and malignant lung solitary pulmonary nodules (SPN), and analyze the association between circulating tumor cell (CTC) levels and different subtypes of lung adenocarcinoma.

Methods: A total of 200 patients (80 with SPNs and 120 diagnosed with lung cancer) were included in the study. The CTC levels were quantified by identifying the folate receptor on the surface of tumor cells; clinical tumor specific markers were detected by biochemical immunization. Read More

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http://dx.doi.org/10.1111/1759-7714.12851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209798PMC
November 2018
3 Reads

The plasma glutamate concentration as a complementary tool to differentiate benign PET-positive lung lesions from lung cancer.

BMC Cancer 2018 Sep 3;18(1):868. Epub 2018 Sep 3.

Applied and Analytical Chemistry, Institute for Materials Research, Hasselt University, Agoralaan Building D, B-3590, Diepenbeek, Belgium.

Background: Pulmonary imaging often identifies suspicious abnormalities resulting in supplementary diagnostic procedures. This study aims to investigate whether the metabolic fingerprint of plasma allows to discriminate between patients with lung inflammation and patients with lung cancer.

Methods: Metabolic profiles of plasma from 347 controls, 269 cancer patients and 108 patients with inflammation were obtained by H-NMR spectroscopy. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-018-4755-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122613PMC
September 2018
18 Reads

[Advancement of Common Localization of Solitary Pulmonary Nodules 
for Video-assisted Thracoscopic Surgery].

Zhongguo Fei Ai Za Zhi 2018 Aug;21(8):628-634

Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.

Recently, with the proliferation of high-resolution computed tomography (CT), the frequency of small pulmonary nodules appears higher and more precise than previously estimated, especially in CT screening in patients with high risk factors for lung cancer. Video-assisted thoracoscopic surgery (VATS) provides a new minimally invasive treatment for the diagnosis and treatment of small pulmonary nodules. The VATS results in less pain, shorter hospital stay, and reduced surgical complications, making it more widely available. Read More

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http://dx.doi.org/10.3779/j.issn.1009-3419.2018.08.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105347PMC
August 2018
2 Reads

The value of the air bronchogram sign on CT image in the identification of different solitary pulmonary consolidation lesions.

Medicine (Baltimore) 2018 Aug;97(35):e11985

Shandong Medical Imaging Research Institute Affiliated to Shandong University.

The aim of the present study is to investigate the value of air bronchogram sign on computed tomography (CT) image in the differential diagnosis of solitary pulmonary consolidation lesions (SPLs).A total of 105 patients (including 39 cases of lung cancer, 43 cases of tuberculosis, and 23 cases of pneumonia) with SPLs were evaluated for the CT features of air bronchogram sign in this retrospective study. The shape and lumen of the bronchi with air bronchogram sign, the length of the involved bronchus with air bronchogram sign, the length of lesion on the same plane and direction, and the ratio between the length of the involved bronchus and that of the lesion were evaluated. Read More

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http://dx.doi.org/10.1097/MD.0000000000011985DOI Listing
August 2018
3 Reads
5.723 Impact Factor

Ultralow dose CT for follow-up of solid pulmonary nodules: A pilot single-center study using Bland-Altman analysis.

Medicine (Baltimore) 2018 Aug;97(34):e12019

Department of Radiology.

Solid pulmonary nodules are a common finding requiring serial computed tomography (CT) imaging. We sought to explore the detection and measurement accuracy of an ultralow-dose CT (ULDCT) protocol compared with our standard low-dose CT (LDCT) nodule follow-up protocol.In this pragmatic single-center pilot prospective cohort study, patients scheduled for clinically indicated CT surveillance of 1 or more known solid pulmonary nodules >2 mm underwent ULDCT immediately after routine LDCT. Read More

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http://dx.doi.org/10.1097/MD.0000000000012019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112944PMC
August 2018
9 Reads