314,295 results match your criteria Solid Omental Tumors


Cancer stem cells in relation to treatment.

Jpn J Clin Oncol 2018 Dec 12. Epub 2018 Dec 12.

Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.

The classical cancer therapies, including chemotherapy and radiation therapy, can initially show good results and tumor shrinkage; however, for most cancer patients disease recurrence is a common event. This tumor regrowth following therapy is now thought to depend on a small population of cancer stem cells (CSCs), which, similar to other stem cells, have the capacity for self-renewal and multipotent differentiation. Cancer stem cells have been identified based on cell surface protein expression in many tumor types, and for all diseases studied, this specific cell population is required for serial transplantation in animal models. Read More

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December 2018

Multicenter experience with large panel next-generation sequencing in patients with advanced solid cancers in Japan.

Jpn J Clin Oncol 2018 Dec 12. Epub 2018 Dec 12.

Department of Clinical Genetics, Yokohama City University Hospital, Yokohama, Japan.

Background: Application of next-generation DNA sequencing (NGS) has recently become increasingly common in the field of clinical oncology in several countries around the world. In Japan also, a system for applying NGS to routine clinical practice is gradually being established. During this process, we introduced in Japan the tumor-profiling MSK-IMPACT (Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets) assay. Read More

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December 2018

Electrical transport and gas sensing characteristics of dielectrophoretically aligned MBE grown catalyst free InAs nanowires.

Nanotechnology 2018 Dec 12. Epub 2018 Dec 12.

DRDO Solid State Physics Laboratory, Lucknow Road, Timarpur, Delhi, Delhi, 110054, INDIA.

In this report, the precise alignment of catalyst free InAs nanowires (NWs) on pre-patterned Au microelectrodes by dielectrophoresis (DEP) technique for gas sensing applications is presented. The catalyst free InAs NWs have been grown on Si (111) substrate by molecular beam epitaxy (MBE) technique. The effect of dispersing solvents, electrode geometries and gaps, magnitude, frequency and duration of applied voltage etc. Read More

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December 2018

Electroluminescence of intrashell transitions in Eu doped single ZnO nanowires.

Nanotechnology 2018 Dec 12. Epub 2018 Dec 12.

Institute for Solid State Physics, Friedrich-Schiller Universitat Jena, Max-Wien-Platz 1, D-07743 Jena, Jena, GERMANY.

Tunable nanoscale light emitters are essential to accomplish future multifunctional optoelectronic nano-devices. Here, we present an approach for achieving red electroluminescence from single ZnO nanowires implanted with Europium ions. The electroluminescence is emitted mainly from the end facets of ZnO nanowires at room temperature under the application of an AC voltage. Read More

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December 2018

Electroluminescence Generation in PbS Quantum Dot Light Emitting Field Effect Transistors with Solid State Gating.

ACS Nano 2018 Dec 12. Epub 2018 Dec 12.

The application of light emitting field effect transistors (LEFET) is an elegant way of combining electrical switching and light emission in a single device architecture instead of two. This allows for a higher degree of miniaturisation and integration in future opto-electronic applications. Here, we report on a LEFET based on lead sulphide quantum dots processed from solution. Read More

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December 2018

Live nanoscopic to mesoscopic topography reconstruction with an optical microscope for chemical and biological samples.

PLoS One 2018 12;13(12):e0207881. Epub 2018 Dec 12.

LAI, Aix Marseille Univ, CNRS, INSERM, Marseille, France.

Macroscopic properties of physical and biological processes like friction, wetting, and adhesion or cell migration are controlled by interfacial properties at the nanoscopic scale. In an attempt to bridge simultaneously investigations at different scales, we demonstrate here how optical microscopy in Wet-Surface Ellipsometric Enhanced Contrast (Wet-SEEC) mode offers imaging and measurement of thin films at solid/liquid interfaces in the range 1-500 nm with lateral optical resolution. A live, label-free and noninvasive methodology integrated with microfluidic devices allowed here characterization of polymers and proteins patterns together with corresponding phenotypes of living cells. Read More

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December 2018

Multiplexed CRISPR/Cas9-mediated knockout of 19 Fanconi anemia pathway genes in zebrafish revealed their roles in growth, sexual development and fertility.

PLoS Genet 2018 Dec 12;14(12):e1007821. Epub 2018 Dec 12.

Cancer Genomics Unit, Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

Fanconi Anemia (FA) is a genomic instability syndrome resulting in aplastic anemia, developmental abnormalities, and predisposition to hematological and other solid organ malignancies. Mutations in genes that encode proteins of the FA pathway fail to orchestrate the repair of DNA damage caused by DNA interstrand crosslinks. Zebrafish harbor homologs for nearly all known FA genes. Read More

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December 2018
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Cell-based immunotherapy in gynecologic malignancies.

Curr Opin Obstet Gynecol 2018 Dec 11. Epub 2018 Dec 11.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Stanford Women's Cancer Center, Stanford University School of Medicine, Stanford, California, USA.

Purpose Of Review: To provide an update on cell-based immunotherapies in solid tumors particularly in gynecological cancers.

Recent Findings: Improvements have been made in engineering T cells to overcome the immunosuppressive environment in ovarian cancer. Significant efforts are underway to create 'off the shelf' cell therapies which leverage natural killer (NK) cells and would not rely on engineering a patient's T cells. Read More

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December 2018

Active Targeting of Cancer Cells by Nanobody Decorated Polypeptide Micelle with Bioorthogonally Conjugated Drug.

Nano Lett 2018 Dec 12. Epub 2018 Dec 12.

Polypeptides are exceptionally promising carriers for chemotherapeutics: they have minimal toxicity, can be recombinantly synthesized with precise control over molecular weight, and enhance drug pharmacokinetics as self-assembled nanoparticles. Polypeptide-based systems also provide the ability to achieve active targeting with genetically encoded targeting ligands. While passive targeting promotes accumulation of nanocarriers in solid tumors, active targeting provides an additional layer of tunable control and widens the therapeutic window. Read More

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December 2018
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Singular dynamics in the failure of soft adhesive contacts.

Soft Matter 2018 Dec 12. Epub 2018 Dec 12.

Department of Physics, Williams College, Williamstown, MA, USA. and Department of Materials, ETH Zürich, Zürich, Switzerland.

We characterize the mechanical recovery of compliant silicone gels following adhesive contact failure. We establish broad, stable adhesive contacts between rigid microspheres and soft gels, then stretch the gels to large deformations by pulling quasi-statically on the contact. Eventually, the adhesive contact begins to fail, and ultimately slides to a final contact point on the bottom of the sphere. Read More

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December 2018

Solid-phase synthesis of a novel phalloidin analog with on-bead and off-bead actin-binding activity.

Chem Commun (Camb) 2018 Dec 12. Epub 2018 Dec 12.

Chemistry Department, UBC, 2036 Main Mall, Vancouver, V6T-1Z1, Canada.

Specific effectors of actin polymerization have found use as dynamic probes of cellular morphology that may be used to gauge cellular response to stimuli and drugs. Of various natural products that target actin, phalloidin is one of the most potent and selective inhibitors of actin depolymerization. Phalloidin and related members of the phallotoxin family are macrocyclic heptapeptides bearing a characteristic and rigidifying transannular tryptathionine bridge. Read More

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December 2018

Cation Exchange at the Interfaces of Ultrathin Films of Fluorous Ionic Liquids on Ag(111).

Langmuir 2018 Dec 12. Epub 2018 Dec 12.

In the context of applications with thin ionic liquid (IL) films on solid supports, we studied the ion distribution within mixed thin IL films by angle-resolved X-ray photoelectron spectroscopy. After deposition of 1-methyl-3-octylimidazolium hexafluorophosphate, [CCIm][PF], on top of a wetting layer (WL) of 3-methyl-1-(3,3,4,4,4-pentafluorobutyl)imidazolium hexafluorophosphate, [PFBMIm][PF], on Ag(111) at room temperature (RT), we find a preferential enrichment of the [PFBMIm] cation at the IL/vacuum interface. In a similar deposition experiment at 82 K, this cation exchange at the IL/solid interface does not occur. Read More

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December 2018

Asphaltene Adsorption from Toluene onto Silica Through Thin Water Layers.

Langmuir 2018 Dec 12. Epub 2018 Dec 12.

Asphaltenes in crude oil play a pivotal role in reservoir oil production because they control rock-surface wettability. Upon crude-oil invasion into a brine-filled reservoir trap, rock adherence of sticky asphaltene agglomerates formed at the crude oil/brine interface can change the initially water-wet porous medium into mixed-oil wetting. If thick, stable water films coat the rock surfaces, however, asphaltenic-oil adhesion is thought to be prevented. Read More

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December 2018

Electronic Transport through DNA Nucleotides in Atomically Thin Phosphorene Electrodes for Rapid DNA Sequencing.

ACS Appl Mater Interfaces 2018 Dec 12. Epub 2018 Dec 12.

Rapid progresses in developing the fast, low-cost, and reliable methods for DNA sequencing are envisaged for development of personalized medicine. In this respect, nanotechnology has paved the role for the development of advanced DNA sequencing techniques including sequencing with solid-state nanopores or nanogaps. Herein, we have explored the application of a black phosphorene based nanogap-device for DNA sequencing. Read More

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December 2018

Atomistic Insight into Ion Transport and Conductivity in Ga/Al-Substituted LiLaZrO Solid Electrolytes.

ACS Appl Mater Interfaces 2018 Dec 12. Epub 2018 Dec 12.

Garnet-structured LiLaZrO is a promising solid electrolyte for next-generation solid-state Li batteries. However, sufficiently fast Li-ion mobility required for battery applications only emerges at high temperatures, upon a phase transition to cubic structure. A well-known strategy to stabilize the cubic phase at room temperature relies on aliovalent substitution; in particular, the substitution of Li by Al and Ga ions. Read More

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December 2018

Distinct Binding Characteristics of Pathogenic Anti-Platelet Factor-4/Polyanion Antibodies to Antigens Coated on Different Substrates: A Perspective on Clinical Application.

ACS Nano 2018 Dec 12. Epub 2018 Dec 12.

Institute for Immunology and Transfusion Medicine , University Medicine Greifswald , 17475 Greifswald , Germany.

The polyanion heparin, which is frequently used in patients, complexes with the platelet-derived cationic chemokine platelet factor (PF4, CXCL4). This results in the formation of anti-PF4/heparin antibodies (anti-PF4/H Abs). Anti-PF4/H Abs are classified into three groups: (i) nonpathogenic Abs (group 1) with no clinical relevance; (ii) pathogenic heparin-dependent Abs (group 2), which activate platelets and can cause the severe adverse drug effect heparin-induced thrombocytopenia (HIT); and (iii) pathogenic autoimmune-HIT Abs (group 3), in which group 3 anti-PF4/H Abs causes a HIT-like autoimmune disease in the absence of heparin. Read More

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December 2018

Proteomic analysis of the acquired enamel pellicle formed on human and bovine tooth: a study using the Bauru in situ pellicle model (BISPM).

J Appl Oral Sci 2018 Dec 10;27:e20180113. Epub 2018 Dec 10.

Universidade de São Paulo, Faculdade de Odontologia de Bauru, Departmento de Ciências Biológicas, Bauru, SP, Brasil.

Objectives: The acquired enamel pellicle (AEP) is an organic film, bacteria-free, formed in vivo as a result of the selective adsorption of salivary proteins and glycoproteins to the solid surfaces exposed to the oral environment. Objective: This study aimed to compare the proteomic profile of AEP formed in situ on human and bovine enamel using a new intraoral device (Bauru in situ pellicle model - BISPM).

Material And Methods: Material and Methods: One hundred and eight samples of human and bovine enamel were prepared (4×4 mm). Read More

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December 2018

Miniaturized sample preparation methods for saliva analysis.

Bioanalysis 2018 Dec 12. Epub 2018 Dec 12.

Department of Chemistry, Faculty of Science, Qom University, Qom, Iran.

Saliva, as the first body fluid encountering with the exogenous materials, has good correlation with blood and plays an important role in bioanalysis. However, saliva has not been studied as much as the other biological fluids mainly due to restricted access to its large volumes. In recent years, there is a growing interest for saliva analysis owing to the emergence of miniaturized sample preparation methods. Read More

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December 2018

Hydrothermal carbonization of arecanut husk biomass: fuel properties and sorption of metals.

Environ Sci Pollut Res Int 2018 Dec 11. Epub 2018 Dec 11.

Department of Bioenergy, Tamil Nadu Agricultural University, Coimbatore, Tamil Nadu, 641003, India.

In this study, hydrothermal carbonization of arecanut husk and its potential application as an alternate solid fuel and heavy metal sorption (adsorbent) was attempted. Arecanut husk (AH) treated with citric acid for 9 h resulted in the hydrochar yield of 58.7% with increased fixed carbon from 17 to 39. Read More

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December 2018

Use of mature compost as filter media and the effect of packing depth on hydrogen sulfide removal from composting exhaust gases by biofiltration.

Environ Sci Pollut Res Int 2018 Dec 11. Epub 2018 Dec 11.

Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation, College of Resources and Environmental Science, China Agricultural University, Beijing, 100193, China.

A study was conducted to investigate the utilization of mature compost as a biofilter medium for the removal of hydrogen sulfide (HS) from the exhaust gases of the composting process. Source-selected kitchen waste from municipal solid waste was composted in a reactor, and the exhaust gas was passed through a biofilter packed with a 1:4 (wet weight) mixture of mature compost and sand. Two treatments were applied under sterilized and unsterilized conditions to quantify the contribution of microbial activity. Read More

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December 2018

Comparative Analysis of Defects in Mg-Implanted and Mg-Doped GaN Layers on Freestanding GaN Substrates.

Nanoscale Res Lett 2018 Dec 11;13(1):403. Epub 2018 Dec 11.

National Institute for Materials Science, Tsukuba, Ibaraki, 305-0047, Japan.

Inefficient Mg-induced p-type doping has been remained a major obstacle in the development of GaN-based electronic devices for solid-state lighting and power applications. This study reports comparative structural analysis of defects in GaN layers on freestanding GaN substrates where Mg incorporation is carried out via two approaches: ion implantation and epitaxial doping. Scanning transmission electron microscopy revealed the existence of pyramidal and line defects only in Mg-implanted sample whereas Mg-doped sample did not show presence of these defects which suggests that nature of defects depends upon incorporation method. Read More

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December 2018

A new multistep purification method for simultaneously determining organic ultraviolet absorbents in fish tissue.

Environ Monit Assess 2018 Dec 11;191(1):16. Epub 2018 Dec 11.

Key Laboratory of Trace Element Nutrition of National Health Commission, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, 100021, China.

More information is required to improve our understanding of the presence of organic ultraviolet absorbents (UVAs) in organisms and the risks posed to biota. Effective removal of lipids in the determination of UVAs in biological samples is a sample-processing bottleneck. In this study, we optimized a multistep purification method for fish tissue samples extracted using an ultrasonic-assisted extraction method. Read More

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December 2018

Oxytocin reactivity to an emotional challenge paradigm and its relation to social-cognitive functions in healthy volunteers.

J Neural Transm (Vienna) 2018 Dec 11. Epub 2018 Dec 11.

Department of Psychiatry Psychotherapy and Preventive Medicine, LWL University Hospital, Ruhr University Bochum, Alexandrinenstr 1-3, 44791, Bochum, Germany.

The neuropeptide oxytocin (OT) is known to be an important modulator of social cognition. It has been shown that lower OT plasma concentrations are linked to impairments in social cognition. Studies have also shown that intranasal OT may enhance social-cognitive abilities in healthy subjects. Read More

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December 2018

Serum tumor markers and testicular germ cell tumors: a primer for radiologists.

Abdom Radiol (NY) 2018 Dec 11. Epub 2018 Dec 11.

University Hospitals Cleveland Medical Center, 11100 Euclid Ave, Cleveland, OH, 44106, USA.

Serum tumor markers (STMs) play a critical role in the diagnosis, staging and follow-up of both seminomatous and nonseminomatous testicular germ cell neoplasms. Levels of alpha-fetoprotein (AFP), human chorionic gonadotropin (HCG), and lactate dehydrogenase (LDH), especially those measured after orchiectomy, also have implications for patient prognosis. Given that testicular germ cell tumors represent the most common solid tumor in men aged 20-34, radiologists must have familiarity with the clinical utilization and implications of these STMs. Read More

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December 2018
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Use of benzodiazepines and z-drugs not compliant with guidelines and associated factors: a population-based study.

Eur Arch Psychiatry Clin Neurosci 2018 Dec 11. Epub 2018 Dec 11.

Inserm, Bordeaux Population Health Research Center, Team Pharmacoepidemiology, UMR 1219, University of Bordeaux, 33000, Bordeaux, France.

Benzodiazepines and z-drugs are primarily indicated for the treatment of sleep disorders and anxiety symptoms. Their frequent long-term use contrasts with the international guidelines that limit treatment duration to a maximum of 4 weeks. The objective of this study was to assess the frequency of their use that was not in accordance with guidelines in the French general population between 2007 and 2012 and associated characteristics. Read More

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December 2018

Multi-stage optimization approach for sustainable municipal solid waste collection systems in urban areas of Asia's newly industrialized countries.

Environ Manage 2018 Dec 11. Epub 2018 Dec 11.

Institute of Sanitary Engineering and Waste Management (ISAH), Leibniz Universität Hannover, Welfengarten 1, Hannover, 30167, Germany.

A multi-stage optimization approach for sustainable collection system design for urban municipal solid waste is developed for megacities in Asia's newly industrialized countries. The approach combines four methods-analysis of waste and area characteristics, data acquisition and evaluation by GIS, mathematical projection of existing and future collection systems, and identification of most suitable alternatives through comparative multi-criteria decision analysis (MCDA). The approach is applied in Bangalore, India with 1. Read More

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December 2018

Mechanical-activated digital microfluidics with gradient surface wettability.

Lab Chip 2018 Dec 12. Epub 2018 Dec 12.

Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA.

This paper reports a simple yet effective droplet manipulation approach that can displace aqueous droplets over a long distance within the working plane. Repeated patterns with surface gradient wettability were created on a super-hydrophobic surface by laser irradiation. Aqueous droplets as small as 2 μL are moved on the patterns over a long distance under in-plane symmetric cyclic vibration. Read More

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December 2018

A bio-inspired 3D quasi-fractal nanostructure for an improved oxygen evolution reaction.

Chem Commun (Camb) 2018 Dec 12. Epub 2018 Dec 12.

Institute for Advanced Materials, South China Academy of Advanced Optoelectronics and Guangdong Provincial Laboratory of Quantum Engineering and Quantum Materials, South China Normal University, Guangzhou, 510006, China.

We demonstrate a bio-inspired three-dimensional (3D) hierarchical catalyst, based on the Fe-doped nanoarrays of dendritic nickel trees, which provides large surface area, close to optimal electron transport, and large inter-branch open-channels for improving gas-bubble release, outperforming the benchmark catalyst of noble RuO2. Read More

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December 2018

A stability-reversibility map unifies elasticity, plasticity, yielding, and jamming in hard sphere glasses.

Sci Adv 2018 Dec 7;4(12):eaat6387. Epub 2018 Dec 7.

Cybermedia Center, Osaka University, Toyonaka, Osaka 560-0043, Japan.

Amorphous solids, such as glasses, have complex responses to deformations, with substantial consequences in material design and applications. In this respect, two intertwined aspects are important: stability and reversibility. It is crucial to understand, on the one hand, how a glass may become unstable due to increased plasticity under shear deformations, and, on the other hand, to what extent the response is reversible, meaning how much a system is able to recover the original configuration once the perturbation is released. Read More

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December 2018

Utility of "liquid biopsy" using pancreatic juice for early detection of pancreatic cancer.

Endosc Int Open 2018 Dec 10;6(12):E1454-E1461. Epub 2018 Dec 10.

Department of Medicine, Asahikawa Medical University, Asahikawa, Hokkaido 078-8510, Japan.

 Despite advances in the diagnosis of pancreatic ductal adenocarcinoma (PDA), histological evaluation of small and poorly defined masses in the pancreas is uncomfortable and unsafe.  We herein report a case of early stage PDA, in which multiple KRAS mutations were detected in the pancreatic juice preoperatively. A small hypoechoic area adjacent to the portal vein was detected through endoscopic ultrasound in the pancreatic body. Read More

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December 2018

Solid Contact Potentiometric Sensors Based on a New Class of Ionic Liquids on Thiacalixarene Platform.

Front Chem 2018 27;6:594. Epub 2018 Nov 27.

Department of Organic Chemistry, A. M. Butlerov' Chemistry Institute, Kazan Federal University, Kazan, Russia.

New solid-contact potentiometric sensors have been developed for hydrogen phosphate recognition on the basis of ionic liquids containing tetrasubstituted derivatives of thiacalix[4]arene in and conformations with trimethyl- and triethylammonium fragments at the lower rim substituents. The recognition of selected anions including carbonate, hydrogen phosphate, perchlorate, oxalate, picrate, and EDTA was conducted using electrochemical impedance spectroscopy with ferricyanide redox probe. For the potentiometric sensor assembling, the ionic liquids were stabilized by multiwalled carbon nanotubes and carbon black deposited on the glassy carbon electrode. Read More

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November 2018

The Awareness of the Fascial System.

Cureus 2018 Oct 1;10(10):e3397. Epub 2018 Oct 1.

Osteopathy, (SOFI) School of French-Italian Osteopathy, Pisa, ITA.

Fascia is a cacophony of functions and information, a completely adaptable entropy complex. The fascial system has a solid and a liquid component, acting in a perfect symbiotic synchrony. Each cell communicates with the other cells by sending and receiving signals; this concept is a part of quantum physics and it is known as quantum entanglement: a physical system cannot be described individually, but only as a juxtaposition of multiple systems, where the measurement of a quantity determines the value for other systems. Read More

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October 2018

Successfully Treated Norovirus- and Sapovirus-Associated Diarrhea in Three Renal Transplant Patients.

Case Rep Infect Dis 2018 12;2018:6846873. Epub 2018 Nov 12.

Sidney Kimmel Medical College at Thomas Jefferson University, Division of Infectious Diseases, 1015 Chestnut Street, Suite 1020, Philadelphia, PA 19107, USA.

Objectives: To examine the burden of norovirus- and sapovirus-related diarrhea in renal transplant patients and to propose the use of nitazoxanide as a therapeutic option for treatment.

Methods: We reviewed three renal transplant patients with viral diarrhea requiring hospitalization due to acute renal failure and signs of graft rejection. All three patients were treated with nitazoxanide. Read More

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November 2018

Evaluation of RECIST, PERCIST, EORTC, and MDA Criteria for Assessing Treatment Response with Ga68-PSMA PET-CT in Metastatic Prostate Cancer Patient with Biochemical Progression: a Comparative Study.

Nucl Med Mol Imaging 2018 Dec 26;52(6):420-429. Epub 2018 Sep 26.

4Department of Radiology, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India.

Purpose: The aim of the study was to compare response evaluation criteria in solid tumours 1.1 (RECIST 1.1), positron emission tomography response criteria in solid tumours (PERCIST), European organisation for research and treatment of cancer (EORTC), and MD Anderson (MDA) criteria for response assessment by Gallium 68-prostate-specific membrane antigen positron emission tomography-computed tomography (Ga68-PSMA PET-CT) in metastatic adenocarcinoma prostate cancer (mPCa) patients with biochemical progression. Read More

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December 2018

Extraction, Characterization, Antioxidant, and Immunostimulatory Activities of Polysaccharides from .

Evid Based Complement Alternat Med 2018 14;2018:8617070. Epub 2018 Nov 14.

College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.

In this study, optimization of enzyme-assisted extraction, purification, characterization, and its bioactivities of polysaccharides from (HCP) was investigated. It was found that the optimum extraction conditions were 3% of enzyme concentration ( ), 30 of liquid-to-solid ratio ( ), 56°C of extraction temperature ( ), 200W of ultrasonic power ( ), 10 min of extraction time ), and 5 of pH value ( ). Under optimum conditions, the experimental yield (4. Read More

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November 2018

Transcutaneous Electrical Acupoint Stimulation Accelerates the Recovery of Gastrointestinal Function after Cesarean Section: A Randomized Controlled Trial.

Evid Based Complement Alternat Med 2018 13;2018:7341920. Epub 2018 Nov 13.

Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.

Background: Gastrointestinal functional recovery is an important factor affecting postoperative outcome. The aim of this study was to evaluate the effect of transcutaneous electrical acupoint stimulation (TEAS) on gastrointestinal function in women undergoing cesarean section.

Methods: 150 pregnant women undergoing cesarean section were randomly allocated into TEAS, nonacupoint stimulation (sham group), and no stimulation (control group). Read More

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November 2018

Simultaneous Determination of Cr, As, Se, and Other Trace Metal Elements in Seawater by ICP-MS with Hybrid Simultaneous Preconcentration Combining Iron Hydroxide Coprecipitation and Solid Phase Extraction Using Chelating Resin.

Int J Anal Chem 2018 13;2018:9457095. Epub 2018 Nov 13.

Department of Environmental Science, School of Life and Environmental Science, Azabu University, 1-17-71, Fuchinobe, Chuo-ku, Sagamihara-shi, Kanagawa 252-5201, Japan.

In the present study, ICP-MS with a new hybrid simultaneous preconcentration combining solid phase extraction using chelating resin and iron hydroxide coprecipitation in one batch at a single pH adjustment (pH 6.0) were developed for multielement determination of trace metal ions in seawater. In multielement determination, the present method makes it possible to determine Cr(III), As(V), Se (IV), and other 14 trace metal elements (Ti, V, Co, Ni, Cu, Zn, Zr, Ge, Cd, Sb, Sn, W, Pb, and U) in seawater. Read More

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November 2018

miRNA-299-5p regulates estrogen receptor alpha and inhibits migration and invasion of papillary thyroid cancer cell.

Cancer Manag Res 2018 22;10:6181-6193. Epub 2018 Nov 22.

Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang 110001, China,

Background: The incidence of papillary thyroid cancer (PTC) is increasing faster than any other solid tumors worldwide. Invasion and metastasis are the main reasons for the poor prognosis of patients with PTC. Previously, we observed significantly low expression of miRNA-299-5p in invasive PTC tissue samples. Read More

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November 2018

Clinical efficacy of immune checkpoint inhibitors in the treatment of unresectable advanced or recurrent gastric cancer: an evidence-based review of therapies.

Onco Targets Ther 2018 21;11:8239-8250. Epub 2018 Nov 21.

Department of Internal Medicine, Division of Gastroenterology and Hepatology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan,

Standard treatment options for patients with advanced gastric cancer (GC) offer limited efficacy and are associated with some toxicity, which necessitates the development of more effective therapies for improving the treatment outcomes for this disease. Immunotherapy involving immune checkpoint inhibitors (ICIs) which inhibit the programmed death 1 (PD-1)/programmed death ligand 1 interaction has emerged as a new treatment option. Nivolumab, a human IgG4 monoclonal antibody inhibitor of PD-1, has demonstrated promising clinical activity and induced durable responses in patients with advanced GC. Read More

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November 2018
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A Case of Primary Intra-abdominal Synovial Sarcoma.

Indian J Surg Oncol 2018 Dec 22;9(4):636-639. Epub 2018 May 22.

2Department of General and Gastrointestinal Surgery, Medical Trust Hospital, M.G. Road, Kochi, Kerala 682016 India.

Synovial sarcomas are relatively common intermediate-to-high-grade malignant soft tissue tumors, often with an initial indolent course. And among the sarcomas primary intra-abdominal synovial sarcoma is a relatively rare entity that may present with an abdominal mass and diagnosis is usually confirmed by immunohistochemistry. The authors report a case of a 46-year-old man who presented with a large palpable abdominal mass. Read More

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December 2018

HATRICK-Synchronous Triple Primary Tumors of Thyroid.

Indian J Surg Oncol 2018 Dec 18;9(4):592-594. Epub 2018 May 18.

3Department of Pathology, St. John's Medical College and Hospital, Bengaluru, Karnataka India.

Multiple primary cancer (MPC) has an incidence of 1.8% and is defined as having two or more cancers in a single patient. Synchronous tumors are defined as ≥ 2 primary tumors occurring within 6 months of diagnosis of the first primary tumor. Read More

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December 2018

Primary Osteosarcoma of the Breast.

Indian J Surg Oncol 2018 Dec 30;9(4):578-580. Epub 2018 Jul 30.

Department of Surgical Oncology, Bombay Hospital, Bombay hospital Marg, Marine Drive, Mumbai, Maharashtra 400020 India.

Extraskeletal osteosarcomas are extremely rare and account for < 1% of the soft tissue sarcomas. Most common site is in soft tissues of the lower extremities. Primary osteosarcomas of the breast are extremely rare and only a few cases have been reported in literature. Read More

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December 2018

Solid Pseudopapillary Neoplasm of the Pancreas Clinicopathological Characteristics and Long-Term Outcome: a Single-Center Experience.

Indian J Surg Oncol 2018 Dec 18;9(4):483-487. Epub 2018 May 18.

Department of Radiology, GIPMER, New Delhi, India.

Solid pseudopapillary neoplasm is a rare tumor of the pancreas. These tumors are considered to have low malignant potential with good prognosis. Due to its rarity, details about clinical presentation and management of the disease are not very clear. Read More

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December 2018

Bretschneider solution-induced alterations in the urine metabolome in cardiac surgery patients.

Sci Rep 2018 Dec 11;8(1):17774. Epub 2018 Dec 11.

Kidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou branch, College of Medicine, Chang Gung University, Guishan, Taoyuan, Taiwan.

The development of Bretschneider's histidine-tryptophan-ketoglutarate (HTK) cardioplegia solution represented a major advancement in cardiac surgery, offering significant myocardial protection. However, metabolic changes induced by this additive in the whole body have not been systematically investigated. Using an untargeted mass spectrometry-based method to deeply explore the urine metabolome, we sought to provide a holistic and systematic view of metabolic perturbations occurred in patients receiving HTK. Read More

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December 2018

Discrepancies of assessments in a RECIST 1.1 phase II clinical trial - association between adjudication rate and variability in images and tumors selection.

Cancer Imaging 2018 Dec 11;18(1):50. Epub 2018 Dec 11.

Radiology, National Koranyi Institute of TB and pulmonology, Budapest, H-1121, Hungary.

Background: In imaging-based clinical trials, it is common practice to perform double reads for each image, discrepant interpretations can result from these two different evaluations. In this study we analyzed discrepancies that occurred between local investigators (LI) and blinded independent central review (BICR) by comparing reader-selected imaging scans and lesions. Our goal was to identify the causes of discrepant declarations of progressive disease (PD) between LI and BICR in a clinical trial. Read More

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December 2018

A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1.

Genome Biol 2018 Dec 11;19(1):218. Epub 2018 Dec 11.

Stem Cell and Cancer Center, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, 133021, Jilin, China.

Background: Friend leukemia virus integration 1 (FLI1), an ETS transcription factor family member, acts as an oncogenic driver in hematological malignancies and promotes tumor growth in solid tumors. However, little is known about the mechanisms underlying the activation of this proto-oncogene in tumors.

Results: Immunohistochemical staining showed that FLI1 is aberrantly overexpressed in advanced stage and metastatic breast cancers. Read More

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December 2018

Survival marker genes of colorectal cancer derived from consistent transcriptomic profiling.

BMC Genomics 2018 Dec 11;19(Suppl 8):857. Epub 2018 Dec 11.

Bioinformatics and Functional Genomics Group, Cancer Research Center (CiC-IBMCC, CSIC/USAL/IBSAL), Consejo Superior de Investigaciones Cientificas (CSIC) and University of Salamanca (USAL), Salamanca, Spain.

Background: Identification of biomarkers associated with the prognosis of different cancer subtypes is critical to achieve better therapeutic assistance. In colorectal cancer (CRC) the discovery of stable and consistent survival markers remains a challenge due to the high heterogeneity of this class of tumors. In this work, we identified a new set of gene markers for CRC associated to prognosis and risk using a large unified cohort of patients with transcriptomic profiles and survival information. Read More

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December 2018

A comparison of satellite-based indices for hazard assessment of MSW open dumps using spatial analysis.

Waste Manag Res 2018 Dec 11:734242X18815963. Epub 2018 Dec 11.

1 Remote Sensing and GIS Group, Department of Space Science, University of the Punjab, Lahore, Pakistan.

This study compares the suitability of different satellite-based vegetation indices (VIs) for environmental hazard assessment of municipal solid waste (MSW) open dumps. The compared VIs, as bio-indicators of vegetation health, are normalized difference vegetation index (NDVI), soil adjusted vegetation index (SAVI), and modified soil adjusted vegetation index (MSAVI) that have been subject to spatio-temporal analysis. The comparison has been made based on three criteria: one is the exponential moving average (EMA) bias, second is the ease in visually finding the distance of VI curve flattening, and third is the radius of biohazardous zone in relation to the waste heap dumped at them. Read More

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December 2018

Deterministic switching of the growth direction of self-catalyzed GaAs nanowires.

Nano Lett 2018 Dec 11. Epub 2018 Dec 11.

Typical vapor-liquid-solid growth of nanowires is restricted to vertical one-dimensional geometry, while there is a broad interest for more complex structures in the context of electronics and photonics applications. Controllable switching of the nanowire growth direction opens up new horizons in the bottom-up engineering of self-assembled nanostructures, for example, to fabricate interconnected nanowires used for quantum transport measurements. In this work, we demonstrate a robust and highly controllable method for deterministic switching of the growth direction of self-catalyzed GaAs nanowires. Read More

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December 2018

Probing Conformational Heterogeneity at the Ionic Liquid-Vacuum Interface by Reactive-Atom Scattering.

J Phys Chem Lett 2018 Dec 11. Epub 2018 Dec 11.

The atomic-level description of liquid interfaces has lagged behind that of solid crystalline surfaces, because existing experimental techniques have been limited in their capability to report molecular structure in a fluctuating liquid interfacial layer. We have moved toward a more detailed experimental description of the gas-liquid interface by studying the F-atom scattering dynamics on a common ionic liquid, 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide. When given contrast by deuterium labeling, the yield and dynamical behavior of reactively scattered HF isotopologues can resolve distinct signatures from the cation butyl, methyl, and ring groups, which help to quantify the relative populations of cation conformations at the liquid-vacuum interface. Read More

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December 2018