Search Our Scientific Publications & Authors

J Clin Sleep Med 2020 May 22. Epub 2020 May 22.

Department of Otolaryngology-Head and Neck Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Study Objectives: To investigate the fiber type distribution in palatopharyngeal muscle via adenosine triphosphatase (ATPase) and Quantitative Real-time Polymerase Chain Reaction (qRT-PCR) in children with severe obstructive sleep apnea (OSA).

Methods: There were 12 severe childhood OSA undergoing tonsillectomy, while 15 simple snoring as control group. Both groups were diagnosed by polysomnography (PSG). Read More

Facial Plast Surg Aesthet Med 2020 May 19. Epub 2020 May 19.

Department of Otolaryngology, Massachussetts Eye and Ear, Boston, Massachussetts, USA.

Functional septorhinoplasty (FSRP) has been shown to improve both global and disease-specific quality of life (QOL). However, the mechanism by which FSRP improves QOL has not been fully defined. We reasoned that NAO may impact sleep quality and, therefore, studied the relationship using validated patient-reported outcome measures. Read More

Phys Eng Sci Med 2020 May 6. Epub 2020 May 6.

State Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head and Neck Surgery, Laboratory of ENT-HNS Disease, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510120, China.

Snoring is a typical characteristic of obstructive sleep apnea hypopnea syndrome (OSAHS) and can be used for its diagnosis. The purpose of this paper is to develop an automatic snoring detection algorithm for classifying snore and non-snore sound segments, which have been segmented from a whole-night sleep sound signal using a spectral entropy method, based on convolutional neural network (CNN) descriptors extracted from audio maps. For each sound segment, the time-domain waveform, spectrum, spectrogram, Mel-spectrogram and CQT-spectrogram are calculated. Read More

ORL J Otorhinolaryngol Relat Spec 2020 May 6:1-8. Epub 2020 May 6.

Department of Head-Neck Surgery, Otolaryngology, Head-Neck and Oral Surgery Unit, Morgagni Pierantoni Hospital, Azienda USL della Romagna, Forlì, Italy.

Background: A new transoral tongue base surgical procedure for the treatment of snoring and obstructive sleep apnea (OSA) is described. It is named "Robo-Cob" technique because it is similar to transoral robotic surgery (TORS) but it is performed by means of coblation technology in order to resect the tongue base in countries where TORS is not an available option for such benign conditions.

Methods: In this prospective, randomized, controlled trial, the new Robo-Cob technique was carried out in 25 adult OSA patients with confirmed tongue base hypertrophy at preoperative drug-induced sedation endoscopy. Read More

J Clin Sleep Med 2020 May 1. Epub 2020 May 1.

Orthodontic Clinic, Faculty of Dentistry, Université de Montréal, Canada.

Study Objectives: To evaluate the prevalence of craniofacial/orthodontic abnormalities and oral dysfunctions in a population of children with persistent sleep-disordered breathing (SDB) despite adenotonsillectomy (A&T).

Methods: Medical charts of 4000 SDB children operated in a tertiary hospital were retrospectively reviewed. Patients reporting persistent SDB symptoms were invited to an orthodontic/myo-functional evaluation following the Sleep Clinical Score (SCS), followed by a one-night ambulatory type III sleep study. Read More

Sleep Breath 2020 Apr 29. Epub 2020 Apr 29.

Integrated Sleep Surgery Team UCBM, Unit of Otolaryngology, Integrated Therapies in Otolaryngology, Campus Bio-Medico University, Rome, Italy.

Background: The use of barbed sutures (BS) for the treatment of retropalatal collapse and vibration in patients suffering from snoring and obstructive sleep apnea (OSA) has significantly increased in the last few years. Many surgeons have discovered the advantages and unique properties of the BS and allowed the popular surgical pharyngoplasty techniques to be updated and improved.

Methods: A systematic review was performed to identify all the clinical studies concerning the different barbed pharyngoplasty (BP) techniques used for the treatment of palatal collapse in snoring and OSA patients. Read More

JAMA Netw Open 2020 Apr 1;3(4):e203125. Epub 2020 Apr 1.

Department of Anesthesiology, Washington University in St Louis, St Louis, Missouri.

Importance: Obstructive sleep apnea has been associated with postoperative delirium, which predisposes patients to major adverse outcomes. Positive airway pressure may be an effective intervention to reduce delirium in this population.

Objectives: To determine if preoperative obstructive sleep apnea is associated with postoperative incident delirium in the intensive care unit and if preoperative positive airway pressure adherence modifies the association. Read More

Maturitas 2020 May 11;135:1-5. Epub 2020 Feb 11.

Division of General Internal Medicine, Mayo Clinic, Rochester, MN, United States; Division of Endocrinology, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, United States. Electronic address:

Objectives: The STOP-BANG questionnaire (snoring, tiredness, observed apneas, high blood pressure, body mass index, age, neck size, gender) was originally validated to screen for obstructive sleep apnea (OSA) in the surgical population. It has been validated in mixed populations of men and women. We aimed to evaluate its reliability for OSA screening of midlife women. Read More

Blood Transfus 2020 May 17;18(3):217-225. Epub 2020 Mar 17.

National Research Council of Italy, Institute for Research and Biomedical Innovation, Palermo, Italy.

Background: Obstructive sleep apnoea syndrome (OSAS) describes a spectrum of abnormal breathing patterns during sleep characterised by snoring, increased upper airway resistance and pharyngeal collapsibility, with alteration of normal oxygenation and ventilation. Intermittent desaturations during sleep have multi-organ implications. Adults with OSAS have an increased risk of developing a dysfunctional endothelium that is characterised by greater adherence of inflammatory mediators to endothelial cells and hypercoagulability. Read More

Eur Arch Otorhinolaryngol 2020 Jun 11;277(6):1823-1828. Epub 2020 Mar 11.

Department of Otorhinolaryngology-Head and Neck Surgery, Busan Saint Mary's Hospital, Yongho-dong, Nam-gu, Busan, 538-41, South Korea.

Purpose: Snoring and obstructive sleep apnoea (OSA) exhibit multifactorial aetiologies; mouth breathing increases airway obstruction and upper respiratory tract resistance. Of the many published studies, few have evaluated sleeping subjects. We explored how mouth breathing affected the upper respiratory tract anatomy and OSA during sleep. Read More

Medicine (Baltimore) 2020 Mar;99(10):e19329

Department of Otorhinolaryngology-Head and Neck Surgery, Chungbuk National University College of Medicine, Chungbuk National University Hospital, Cheongju, Korea.

Sleep-disordered breathing symptoms may recur in some children after successful adenoidectomy. A potential etiology that warrants consideration is torus tubarius hypertrophy (TTH) as well as residual or recurrent adenoid hypertrophy. Here, we report our experience and the treatment outcomes with microscopic coblator-assisted partial resection of TTH. Read More

World J Clin Cases 2020 Feb;8(4):679-688

Department of Otolaryngology Head and Neck Surgery, Department of The Sleep Medicine Center, Shengjing Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.

Background: Childhood obstructive sleep apnea hypopnea syndrome (OSAHS) is a common clinical disease that can cause serious complications if not treated in time. The preferred treatment for OSAHS in children is surgery.

Aim: To observe the effects of soft palate-pharyngoplasty on postoperative outcome, pharyngeal formation, and possible complications. Read More

Int J Cardiol Heart Vasc 2020 Feb 19;26:100447. Epub 2019 Dec 19.

Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.

Background: Recent studies have suggested an association between sleep apnea (SA) and atrial fibrillation (AF). We aimed to study the prevalence, characteristics, risk factors and type of sleep apnea (SA) in ablation candidates with paroxysmal AF.

Methods/results: We prospectively studied 579 patients with paroxysmal AF, including 157 women (27. Read More

J Otolaryngol Head Neck Surg 2020 Mar 4;49(1):11. Epub 2020 Mar 4.

Department of Otorhinolaryngology head and neck surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, 56 Nanlishi Road, Xicheng, Beijing, China.

Background: The known risk factors of childhood OSAS include tonsillar and adenoidhypertrophy, obesity, craniofacial anomalies, neuromuscular disorders and African-American (AA) ancestry. Whether other factors such as allergic rhinitis (AR), premature, environmental tobacco smoking (ETS) are associated with OSAS are inconsistent in different studies. Our study enrolled children of a broad age range and included potential risk factors of OSAS derived from previous studies and our own experience. Read More

Laryngoscope 2020 Feb 28. Epub 2020 Feb 28.

Division of Sleep Surgery, Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, U.S.A.

Objectives/hypothesis: Hypoglossal nerve stimulation (HGNS) effectively treats obstructive sleep apnea in select patients. Drug-induced sleep endoscopy (DISE) is required for HGNS candidacy. Data suggest that mandibular advancement (MA) devices and HGNS share similar target populations. Read More

FEBS Open Bio 2020 May 22;10(5):761-766. Epub 2020 Mar 22.

Department of Otorhinolaryngology-Head and Neck Surgery, Shandong Provincial Hospital affiliated to Shandong University, Jinan City, China.

Adenoidal hypertrophy (AH) is a common disorder in the pediatric population, with common symptoms including mouth breathing, nasal congestion, hyponasal speech, snoring and obstructive sleep apnea. Although the pathogenesis of AH has not been fully elucidated, recent studies have indicated that immune responses may play an important role in AH. Tumor necrosis factor-alpha (TNF-α)-induced protein-8 like-2 (TIPE2) is a newly identified protein that negatively regulates the activation of inflammatory pathways. Read More

Facial Plast Surg Aesthet Med 2020 Jan/Feb;22(1):25-35

Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Boston, Massachusetts.

Sleep-disordered breathing (SDB) represents a spectrum of sleep-related disorders associated with significant medical comorbidities. Nasal airway surgery has been shown to improve SDB but no large-scale studies exist that describe the long-term impact of surgery on patient perception of snoring and nasal obstruction. To characterize longitudinal snoring symptoms and nasal obstruction after functional nasal surgery for patients with SDB, stratified by history of snoring or obstructive sleep apnea (OSA). Read More

Laryngoscope 2020 Feb 11. Epub 2020 Feb 11.

Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Objective: To assess the risk of Alzheimer's disease (AD) in patients with obstructive sleep apnea (OSA) with or without treatment based on real-world evidence.

Study Design: Retrospective cohort study.

Methods: Patients newly diagnosed with OSA during 1997-2012 were identified using the National Health Insurance Research Database of Taiwan. Read More

Sci Rep 2020 Feb 7;10(1):2101. Epub 2020 Feb 7.

Department of Otorhinolaryngology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.

Lateral pharyngeal wall appears to be a critical culprit of obstructive sleep apnea (OSA) subjects and relocation pharyngoplasty has been expected to be a promising surgical option to correct retropalatal circumferential narrowing in OSA patients. The purpose of our study is to evaluate the therapeutic outcomes of relocation pharyngoplasty and its clinical effectiveness in OSA patients with retropalatal circumferential narrowing. We performed relocation pharyngoplasty combined with nasal surgery in 133 OSA patients with the following characteristics: apnea-hypopnea index (AHI) over 10, retropalatal circumferential narrowing greater than grade I when awake, and redundant soft tissue around the lateral pharyngeal wall. Read More

J Clin Sleep Med 2020 Apr;16(4):635-638

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, Stony Brook Medicine, Stony Brook, New York.

None: Obstructive sleep apnea (OSA) is commonly encountered in the pediatric population and has a large differential diagnosis. As clinicians, we must determine who needs to undergo flexible laryngoscopy to rule out potential obstructing lesions causing OSA. This report presents a 16-year-old female who presented with snoring, "asthma," dysphagia, and OSA. Read More

Otolaryngol Pol 2019 Dec;74(1):6-12

Klinika Otolaryngologii, Uniwersytet Medyczny w Białymstoku.

Introduction Sleep is a physiological state essential for proper functioning of the body. One of the reasons for sleep disorders is obstructive sleep apnea syndrome (OSAS).

Aim: The aim of this research is histological evaluation of the mucous membrane of the soft palate in patients affected by various forms of OSAS. Read More

J Clin Sleep Med 2020 Feb 13;16(2):325-329. Epub 2020 Jan 13.

Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.

None: Arnold-Chiari malformations are structural defects in the base of the skull and cerebellum, when part of the cerebellar tonsils herniates through the foramen magnum into the upper spinal canal, compressing against the brainstem. This anatomical defect can be asymptomatic but often presents with symptoms such as headaches, stridor, dysphagia, and nystagmus. It also presents with a variety of sleep-related breathing disorders such as snoring, obstructive sleep apnea, central sleep apnea, bradypnea, and sleep hypoventilation. Read More

Cleft Palate Craniofac J 2020 Jan 24:1055665619900871. Epub 2020 Jan 24.

Division of Plastic and Reconstructive Surgery, The Children's Hospital of Philadelphia, PA, USA.

Objective: To determine pre- and postoperative prevalence of obstructive sleep apnea (OSA) in patients with 22q11.2 deletion syndrome (DS) undergoing wide posterior pharyngeal flap (PPF) surgery for velopharyngeal dysfunction (VPD).

Design: Retrospective study using pre- and postoperative polysomnography (PSG) to determine prevalence of OSA. Read More

Can J Anaesth 2020 Jun 17;67(6):706-714. Epub 2020 Jan 17.

Département d'anesthésiologie, Centre hospitalier de l'Université de Montréal, Montréal, QC, Canada.

Purpose: Patient characteristics associated with difficult tracheal intubation using a flexible bronchoscope (FB) under general anesthesia have not been prospectively evaluated. This observational study aimed to identify demographic and morphologic factors associated with difficult FB intubation.

Methods: We recruited 420 adult elective surgery patients undergoing tracheal intubation during general anesthesia. Read More

Acta Otorhinolaryngol Ital 2019 Dec;39(6):404-408

Unit of Otorhinolaryngology, Head and Neck Surgery, Humanitas San Pio X, Milan, Italy.

J Clin Med 2020 Jan 3;9(1). Epub 2020 Jan 3.

3rd Department of Surgery, "AHEPA" University Hospital, Aristotle University of Thessaloniki, Medical School, 54636 Thessaloniki, Greece.

Background: Gender affects the clinical presentation of obstructive sleep apnea (OSA). The classic OSA symptoms, such as sleepiness, snoring, and apnea, are not so frequent in women.

Objectives: To evaluate possible gender differences in questionnaires used for OSA prediction, such as the Epworth Sleepiness Scale (ESS), STOP, STOP Bang (SB), Berlin Questionnaire (BQ), Athens Insomnia Scale (AIS), and Fatigue Scale (FS). Read More

Cranio 2020 Jan 7:1-10. Epub 2020 Jan 7.

Department of Pulmonology, Catharina Hospital Eindhoven, Eindhoven, the Netherlands.

: To investigate the effectiveness and adverse events of mandibular advancement device (MAD) in patients with obstructive sleep apnea (OSA) and to identify predictive clinical parameters for therapy success.: A retrospective analysis of 318 patients indicated for MAD therapy, observed in a large teaching hospital in the Netherlands.: Ninety-seven patients (65. Read More

Zhonghua Er Ke Za Zhi 2020 Jan;58(1):13-18

Department of Otolaryngology, Head & Neck Surgery, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.

To evaluate the endothelial function in obstructive sleep apnea syndrome(OSAS) children and to identify related factors of endothelial dysfunction. This was a cross-sectional study. Children with habitual snoring (snoring ≥3 nights per week) admitted to the ward of otolaryngology, head and neck surgery, Beijing Children's Hospital were recruited to this study between 1(st) June 2015 and 1(st) March 2016. Read More

Int J Pediatr Otorhinolaryngol 2020 Apr 24;131:109852. Epub 2019 Dec 24.

Department of Otolaryngology - Head and Neck Surgery, The Pennsylvania State University, College of Medicine, Hershey, PA, USA.

Objective: A common indication for tonsillectomy in children is clinically diagnosed sleep disordered breathing (SDB) without confirmation of obstructive sleep apnea (OSA) by polysomnography (PSG). Our goal was to review rates of post-tonsillectomy respiratory complications in children with SDB without prior PSG in order to develop recommendations for postoperative monitoring and safe hospital discharge in this population.

Methods: Following Institutional Review Board (IRB) approval at Penn State Milton S. Read More

Am J Orthod Dentofacial Orthop 2020 Jan;157(1):91-97

Department of Orofacial Pain and Jaw Function, Västmanland Hospital, Västerås, Sweden.

Introduction: This 10-year prospective cephalometric study evaluates the influence of a mandibular protruding device (MPD) in people with obstructive sleep apnea and snoring.

Methods: A baseline study population of 77 people was followed biennially. After 10 years, 65 people (45 MPD users and 20 stopped-MPD users) were reexamined. Read More

Int Arch Otorhinolaryngol 2020 Jan 4;24(1):e107-e111. Epub 2019 Nov 4.

Department of Otolaryngology, Núcleo de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço de São Paulo, São Paulo, SP, Brazil.

 Obstructive sleep apnea syndrome (OSAS) is a multifactorial disease characterized by episodes of partial or complete collapse during sleep of different regions of the upper airway. Surgery for OSAS evolved with the introduction of different techniques, considering new surgical concept of reconstruction of the upper airway.  To retrospectively evaluate the effectiveness of a new approach aimed at reducing pharyngeal collapse by combining two surgical techniques: lateral and expansion pharyngoplasty. Read More

Sleep Sci 2019 Jul-Sep;12(3):126-131

Universidade Federal de São Paulo, Department of Otolaryngology and Head and Neck Surgery - São Paulo - São Paulo - Brazil.

Importance: Aesthetic rhinoplasty is the fifth surgical procedure most performed worldwide by plastic surgeons. With the growing demand for rhinoplasty, there is an unmet need for research into the profile of patients who seek aesthetic nasal surgery in an attempt to improve not only cosmetic dissatisfactions, but also the manifestations of other, possibly interrelated disorders, especially sleep disturbances.

Objective: To evaluate the sleep quality and the risk of Obstructive Sleep Apnea in patients referred for aesthetic rhinoplasty, as well as the association of these conditions with nasal symptoms. Read More

Int J Oral Maxillofac Surg 2019 Dec 21. Epub 2019 Dec 21.

Department of Otolaryngology, Stanford University School of Medicine, Stanford, California, USA. Electronic address:

Obstructive sleep apnoea (OSA) is characterized by repeated upper airway collapse leading to oxygen desaturation resulting in cardiovascular and neurocognitive sequelae. Upper airway surgeries such as palatopharyngoplasty, tongue base surgery, and maxillomandibular advancement can improve patient tolerance of continuous positive airway pressure, quality of life, and the severity of OSA. Upper airway stimulation (UAS) of the hypoglossal nerve is a contemporary US Food and Drug Administration-approved treatment modality for OSA with a fundamentally different mechanism. Read More

Niger Med J 2019 Sep-Oct;60(5):234-237. Epub 2019 Nov 26.

Department of Anaesthesia, Lagos School of Anaesthetic Studies, General Hospital, Lagos, Nigeria.

Background: All adenoid and tonsils tissue specimens are routinely histologically examined in pediatric otorhinolaryngology practice worldwide. This study aimed at determining the sociodemographic features, clinical presentation, indications, postoperative management, and histological diagnosis of the adenoid and tonsils tissues.

Materials And Methods: This is a retrospective hospital-based study of patients who had adenotonsillectomy done between August 2008 and July 2018 at Golden Cross Infirmary Hospital, Festac Town, Lagos, Nigeria. Read More

Sleep Breath 2020 Mar 10;24(1):287-296. Epub 2019 Dec 10.

Division of Sleep Surgery, Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Stanford University, 801 Welch Road, Stanford, CA, 94304, USA.

Objective: Distraction osteogenesis maxillary expansion (DOME) is a reliable method to expand the nasal floor and hard palatal vault in adults with obstructive sleep apnea (OSA). DOME results in a reduction in the apnea-hypopnea index (AHI) and subjective report of improved nasal breathing. Using rhinomanometry augmented computational fluid dynamic (CFD) modeling, we propose a mechanism of how DOME reduces upper airway pharyngeal collapse in adults with OSA. Read More

Sleep Breath 2019 Dec 7. Epub 2019 Dec 7.

Department of Otorhinolaryngology - Head and Neck Surgery, Sungkyunkwan University School of Medicine, Samsung Medical Center, 06351, Seoul, Republic of Korea.

Purpose: The aim of this study is to determine the impact of myofunctional therapy support program (MTSP) based on self-efficacy theory compared to no support during myofunctional therapy (MT) in patients with obstructive sleep apnea (OSA).

Methods: Thirty-one patients with OSA were randomized into two groups: 12 weeks of treatment with the MTSP developed in this study (experimental group) and one education session of MT (control group). Patients were evaluated at the beginning and the end of the study using questionnaires (self-efficacy scale, Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, snoring intensity and frequency, dry mouth) and polysomnography. Read More

Indian J Dent Res 2019 Jul-Aug;30(4):625-629

Balaji Dental and Craniofacial Hospital, Teynampet, Chennai, Tamil Nadu, India.

Severe restriction of airway volume in the orofacial region, caused by temporomandibular joint (TMJ) ankylosis, may lead to obstructive sleep apnea (OSA). If the TMJ ankylosis is progressive, rarely, the caregivers may fail to notice the problem. Such patients may have only symptoms of snoring, daytime sleepiness, fatigue, inability to concentrate, and irritability. Read More

Auris Nasus Larynx 2019 Nov 13. Epub 2019 Nov 13.

Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Chonnam National University Hospital, 42 Jebong-ro Dong-gu, Gwangju 61469, South Korea. Electronic address:

Objective: We analyzed the clinical characteristics of patients with isolated epiglottic collapse (IEC) who had an epiglottic anteroposterior (AP) collapse as the only cause of snoring during drug-induced sleep endoscopy (DISE).

Methods: A retrospective analysis of 334 consecutive DISE examinations was performed. Patients who had only epiglottic AP collapse were designated as the IEC group. Read More

Am J Otolaryngol 2020 Jan - Feb;41(1):102303. Epub 2019 Oct 5.

Department of Otolaryngology - Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, NJ, USA.

Purpose: The Pillar Palatal Implant System is a minimally invasive procedure for the treatment of obstructive sleep apnea and snoring. Prior studies have examined the effectiveness of this procedure, however no prior study has thoroughly evaluated its complications. We anticipate that this analysis will provide valuable insight into these procedures which can be used in patient education and post-operative follow-up. Read More

Sleep Breath 2019 Nov 12. Epub 2019 Nov 12.

Sleep Lab, Hospital de Clínicas, Ciudad Autónoma de Buenos Aires, Argentina.

Objective: To evaluate the performance of clinical criteria (CC) for diagnosis and initiation of empirical treatment with continuous positive airway pressure (CPAP) in patients with suspected obstructive sleep apnea (OSA) compared with the treatment decision based on sleep studies (polysomnography or respiratory polygraphy), guidelines, and experience of participating physicians.

Methods: This was a simulated intention-to-treat study in a retrospective (G1) and prospective (G2) cohort. Four observers (two per group) called CC1 and CC2 reviewed the sleep questionnaires and indicated CPAP if the patients presented snoring, frequent apneas (≥ 3-4/week), body mass index (BMI) > 25 kg/m, sleepiness (Epworth > 11), or tiredness (at least 3-4 times per week) and some comorbidity (hypertension, coronary/cerebrovascular event, diabetes). Read More

Cas Lek Cesk 2019 ;158(5):170-174

In the field of sleep disorders, otorhinolaryngology is mainly concerned with snoring and obstructive sleep apnea (OSA). Prevalence of OSA is suggested between 14-49 % of male and 5-30 % of female population, which makes it most common sleep disorder. The treatment of choice is positive airway pressure (PAP) therapy with excellent success rate of 90 %, however many patients dont tolerate it. Read More

Trials 2019 Oct 29;20(1):615. Epub 2019 Oct 29.

Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Antwerp, Belgium.

Background: The amount of mandibular protrusion is a key factor in optimizing the efficacy of mandibular advancement device (MAD) therapy in an individual patient diagnosed with obstructive sleep apnea. This process is called titration and is generally based on resolution of subjective symptoms like snoring and/or daytime sleepiness as a function of protrusion. An objective approach uses a remotely controlled mandibular positioner (RCMP) during a full-night polysomnography (PSG), in analogy with continuous positive airway pressure (CPAP) titration. Read More

Sleep Med 2020 01 13;65:172-176. Epub 2019 Jun 13.

Division of Sleep Surgery, Dept. of Otolaryngology-Head & Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA. Electronic address:

Objectives: This study correlates objective and subjective measurements associated with obstructive sleep apnea (OSA) to define the efficacy of Distraction Osteogenesis Maxillary Expansion (DOME) to treat adult OSA patients with narrow maxilla and nasal floor.

Methods: This is a retrospective study reviewing cases from September 2014 through April 2018 with 75 eligible subjects. Inclusion criteria required OSA confirmed by attended polysomnography (PSG). Read More

Eur Arch Otorhinolaryngol 2019 Dec 10;276(12):3539-3542. Epub 2019 Oct 10.

Integrated Sleep Surgery Team, Unit of Integrated Therapies in Otolaryngology, School of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.

Introduction: The "Barbed Snore Surgery" is one of the last technical innovations in palatal surgery for Obstructive Sleep Apnea. The availability of a low-cost surgical model able to replicate tissue consistency and main anatomical structures could be fundamental for the spreading of this surgery. The aim of this study was to assess the feasibility of an ex-vivo ovine model in the surgical training of BSS. Read More

Eur Respir J 2020 Jan 9;55(1). Epub 2020 Jan 9.

Unité de Somnologie et Fonction Respiratoire, Hopital St Antoine, Paris, France.

Background And Aim: Hypoglossal nerve stimulation (HNS) decreases obstructive sleep apnoea (OSA) severity genioglossus muscle activation and decreased upper airway collapsibility. This study assessed the safety and effectiveness at 6 months post-implantation of a novel device delivering bilateral HNS a small implanted electrode activated by a unit worn externally, to treat OSA: the Genio™ system.

Methods: This prospective, open-label, non-randomised, single-arm treatment study was conducted at eight centres in three countries (Australia, France and the UK). Read More

J Clin Sleep Med 2019 10;15(10):1509-1516

CHU Nancy, Pôles des Spécialités Médicales/Département de Pneumologie, Vandoeuvre-lès-Nancy, France.

Study Objectives: Our objectives were to determine in an obese population (body mass index > 35 kg/m²) the number of patients, after gastric bypass (GBP), who no longer met French Ministry of Health criteria for utilizing positive airway pressure (PAP), and the predictive factors of obstructive sleep apnea (OSA) improvement.

Methods: Between June 2012 and August 2014 we diagnosed OSA in 129 incident patients requiring PAP therapy before GBP. A postoperative sleep recording was undertaken for 44 of these patients after a weight loss of at least 10%. Read More

Otolaryngol Head Neck Surg 2019 12 1;161(6):1048-1055. Epub 2019 Oct 1.

Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Objectives: This study is designed to investigate the effects of obstructive sleep apnea/hypopnea syndrome (OSA) surgery on serum leptin levels and metabolic disturbances, both of which contribute to the risk of cardiovascular diseases.

Study Design: Case series with planned data collection.

Setting: Tertiary referral medical center. Read More

Indian J Otolaryngol Head Neck Surg 2019 Sep 8;71(3):352-359. Epub 2019 Feb 8.

2Department of Otorhinolaryngology and Head and Neck Surgery, KG Medical University, Lucknow, India.

The incorporation of telemedicine and artificial intelligence for early screening and assessment of severity of life-style disorders has a great potential for better assessment in a busy outpatient clinic and thereby curtail down the related morbidities. A computer based algorithm based upon standardized questionnaire (from established assessment tools) is designed to assess the risk of obstructive sleep apnoea syndrome (OSAS). In addition the incorporation of basic screening questions of anamnesis help in suggesting a probable diagnosis of sleep related disorder as well. Read More

Eur Respir Rev 2019 Sep 25;28(153). Epub 2019 Sep 25.

LEMP, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.

Oral appliances are increasingly recommended for selected patients with obstructive sleep apnoea (OSA) and those who do not tolerate nor prefer continuous positive airway pressure. The most commonly used oral appliance advances the lower jaw during sleep, the so-called mandibular advancement device (MAD). Patients seek treatment because of disturbing snoring, daytime symptoms, apnoeas that disturb sleep and the longer term consequences with regard to cardiovascular risks. Read More

Int J Pediatr Otorhinolaryngol 2019 Dec 6;127:109621. Epub 2019 Aug 6.

Otolaryngology, Head and Neck Surgery Department, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. Electronic address:

Objective: This study aimed to identify the heterogeneity of obstructive sleep apnea syndrome clinical presentation in children.

Participants: Children who were 3-14 years old and with obstructive sleep apnea syndrome after polysomnography monitoring (apnea and hypopnea index>5 or obstructive apnea index>1) in the sleep center of Beijing Children's Hospital were included.

Methods: A sleep disorder questionnaire including different combinations of symptoms and co-morbidities of obstructive sleep apnea syndrome in children was used. Read More