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Am J Otolaryngol 2020 Apr 21:102500. Epub 2020 Apr 21.

Chest Diseases, Faculty of Medicine-Kafrelsheikh University, Egypt.

Background: Obstructive sleep apnea syndrome (OSAS) is caused by a complete or partial obstruction of the upper airway. A new Cahali lateral pharyngoplasty as a stand-alone procedure for the treatment of OSA patients, whatever the level and pattern of airway obstruction in patients with CPAP failure or non-compliant patients, is it?

Patients And Methods: 40 patients with known OSAS non-compliant with CPAP or CPAP failures included. BMI, Stop-Bang score, and sleep study parameters were reported before and after the new Cahali pharyngoplasty operation. Read More

Cranio 2020 Apr 18:1-6. Epub 2020 Apr 18.

Department of Oral and Maxillofacial Diseases, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

: Obstructive sleep apnea (OSA) is an increasing health problem worldwide. The aim was to evaluate long-term mandibular advancement device (MAD) therapy outcomes in community dental care among OSA patients in Finland.: In all, 142 (77. Read More

Am J Otolaryngol 2020 Mar 16:102460. Epub 2020 Mar 16.

Bezmialem Vakif University, Faculty of Medicine, Department of Otorhinolaryngology, Fatih, Istanbul, Turkey.

Objective: The objective of this study is to create a new choice of treatment with nasopharyngeal stent in isolated retro palatal obstruction and snoring for the treatment of obstructive sleep apnea syndrome (OSAS).

Material And Method: The study included five patients with mild OSAS and snoring. Nasopharyngeal stents were applied in these patients with drug-induced sedation endoscopy. Read More

Int J Cardiol Heart Vasc 2020 Feb 19;26:100447. Epub 2019 Dec 19.

Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.

Background: Recent studies have suggested an association between sleep apnea (SA) and atrial fibrillation (AF). We aimed to study the prevalence, characteristics, risk factors and type of sleep apnea (SA) in ablation candidates with paroxysmal AF.

Methods/results: We prospectively studied 579 patients with paroxysmal AF, including 157 women (27. Read More

Praxis (Bern 1994) 2020 ;109(3):207-213

Klinik für Pneumologie, Universitätsspital Zürich, Zürich.

CME: Obstructive Sleep Apnea: A Common Disease Obstructive sleep apnea is a common sleep related breathing disorder with a collapse of the upper respiratory tract, leading to repetitive oxygen desaturations and 'micro arousals'. If the physiological sleep architecture is impaired, patients are at risk for an increased daytime sleepiness and an increased blood pressure. Main risk factors are central obesity, age, male sex, (and snoring). Read More

Laryngoscope 2020 Feb 28. Epub 2020 Feb 28.

Division of Sleep Surgery, Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, U.S.A.

Objectives/hypothesis: Hypoglossal nerve stimulation (HGNS) effectively treats obstructive sleep apnea in select patients. Drug-induced sleep endoscopy (DISE) is required for HGNS candidacy. Data suggest that mandibular advancement (MA) devices and HGNS share similar target populations. Read More

Laryngoscope 2020 Feb 11. Epub 2020 Feb 11.

Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Objective: To assess the risk of Alzheimer's disease (AD) in patients with obstructive sleep apnea (OSA) with or without treatment based on real-world evidence.

Study Design: Retrospective cohort study.

Methods: Patients newly diagnosed with OSA during 1997-2012 were identified using the National Health Insurance Research Database of Taiwan. Read More

Acta Otorhinolaryngol Ital 2019 Dec;39(6):404-408

Unit of Otorhinolaryngology, Head and Neck Surgery, Humanitas San Pio X, Milan, Italy.

Cranio 2020 Jan 7:1-10. Epub 2020 Jan 7.

Department of Pulmonology, Catharina Hospital Eindhoven, Eindhoven, the Netherlands.

: To investigate the effectiveness and adverse events of mandibular advancement device (MAD) in patients with obstructive sleep apnea (OSA) and to identify predictive clinical parameters for therapy success.: A retrospective analysis of 318 patients indicated for MAD therapy, observed in a large teaching hospital in the Netherlands.: Ninety-seven patients (65. Read More

Sleep Breath 2019 Nov 12. Epub 2019 Nov 12.

Sleep Lab, Hospital de Clínicas, Ciudad Autónoma de Buenos Aires, Argentina.

Objective: To evaluate the performance of clinical criteria (CC) for diagnosis and initiation of empirical treatment with continuous positive airway pressure (CPAP) in patients with suspected obstructive sleep apnea (OSA) compared with the treatment decision based on sleep studies (polysomnography or respiratory polygraphy), guidelines, and experience of participating physicians.

Methods: This was a simulated intention-to-treat study in a retrospective (G1) and prospective (G2) cohort. Four observers (two per group) called CC1 and CC2 reviewed the sleep questionnaires and indicated CPAP if the patients presented snoring, frequent apneas (≥ 3-4/week), body mass index (BMI) > 25 kg/m, sleepiness (Epworth > 11), or tiredness (at least 3-4 times per week) and some comorbidity (hypertension, coronary/cerebrovascular event, diabetes). Read More

Ethiop J Health Sci 2019 Sep;29(5):585-590

School of Medicine, Georgetown University, Washington, District of Columbia, United States.

Background: Obstructive Sleep Apnea (OSA) is prevalent throughout the world. However, there are currently limited data concerning the prevalence of OSA in populations that originate from developing countries; the prevalence of OSA is expected to rise in these countries. OSA is poorly characterized amongst Ethiopians, and our study is the first to describe clinical characteristics of OSA among Ethiopians. Read More

Trials 2019 Oct 29;20(1):615. Epub 2019 Oct 29.

Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Antwerp, Belgium.

Background: The amount of mandibular protrusion is a key factor in optimizing the efficacy of mandibular advancement device (MAD) therapy in an individual patient diagnosed with obstructive sleep apnea. This process is called titration and is generally based on resolution of subjective symptoms like snoring and/or daytime sleepiness as a function of protrusion. An objective approach uses a remotely controlled mandibular positioner (RCMP) during a full-night polysomnography (PSG), in analogy with continuous positive airway pressure (CPAP) titration. Read More

Cranio 2019 Oct 5:1-12. Epub 2019 Oct 5.

Department of Dental Propedeutics and Esthetics, Faculty of Dentistry, "Iuliu Hațieganu" University of Medicine and Pharmacy Cluj-Napoca , Cluj-Napoca , Romania.

: Oral appliance therapy is a non-invasive treatment that offers a wide variety of oral devices for the treatment of obstructive sleep apnea (OSA). The present review focuses on the effectiveness of mandibular advancement devices for the treatment of OSA. : A systematic review based on the PRISMA checklist was carried out. Read More

Sleep 2019 10;42(10)

Adelaide Institute for Sleep Health: A Flinders Centre for Research Excellence, Flinders University, Adelaide, Australia.

Study Objectives: Poor adherence to continuous positive airway pressure (CPAP) commonly affects therapeutic response in obstructive sleep apnea (OSA). We aimed to determine predictors of adherence to CPAP among participants of the Sleep Apnea and cardioVascular Endpoints (SAVE) trial.

Methods: SAVE was an international, randomized, open trial of CPAP plus usual care versus usual care (UC) alone in participants (45-75 years) with co-occurring moderate-to-severe OSA (≥12 episodes/h of ≥4% oxygen desaturation) and established cardiovascular (CV) disease. Read More

Br Dent J 2019 Sep;227(6):470-473

Consultant Orthodontist, Department of Orthodontics, Victoria Hospital, Kirkcaldy, UK.

Introduction Mandibular replacement appliances (MRAs) can be used in the treatment of snoring, mild to moderate obstructive sleep apnoea and as a second-line treatment where continuous positive airway pressure (CPAP) fails. There is currently a paucity of evidence as to how long these appliances last.Aims Assess the replacement rate for MRAs using this as a proxy for lifespan; estimate the period prevalence of temporomandibular joint disorder (TMJD) and bruxism in the study population. Read More

J Family Med Prim Care 2019 Aug 28;8(8):2728-2731. Epub 2019 Aug 28.

Department of Prosthodontics Crown and Bridge and Implantology, C.K.S. Theja Institute of Dental Sciences and Research, Chadalawada Nagar, Renigunta Road, Renigunta, Tirupati, Andhra Pradesh, India.

Snoring is common disorder in India, which is caused due to obstructive sleep apnea. Nasal continuous positive airway pressure (CPAP) is an effective treatment for this condition. Prefabricated nasal masks lack intimate adaptation and cause air leakage producing discomfort for patient and decrease the compliance for treatment. Read More

Laryngorhinootologie 2019 Sep 9;98(9):638-650. Epub 2019 Sep 9.

The prevalence of mild obstructive sleep apnea (OSA) in adults is 20 %, of moderate to severe OSA about 6-7 %. The current gold standard for the treatment of moderate to severe OSA is the continuous positive airway pressure (CPAP) therapy. It is the most effective treatment modality, if there is good compliance and therapy adherence. Read More

Dental Press J Orthod 2019 Aug 1;24(3):99-109. Epub 2019 Aug 1.

Private practice (Brasília/DF, Brazil).

Introduction: Obstructive Sleep Apnea and Hypopnea Syndrome (OSAS) is a highly prevalent disease with serious consequences for the patients' lives. The treatment of the condition is mandatory for the improvement of the quality of life, as well as the life expectancy of the affected individuals. The most frequent treatments provided by dentistry are mandibular advancement devices (MAD) and orthognathic surgery with maxillomandibular advancement (MMA). Read More

J Thorac Dis 2019 May;11(5):2153-2164

Lane Fox Unit/Sleep Disorders Centre, Guy's & St Thomas' NHS Foundation Trust, London, UK.

Obstructive sleep apnoea (OSA) is a global health problem of increasing prevalence. Effective treatments are available with continuous positive airway pressure (CPAP) therapy and mandibular advancement devices (MAD). However, there is limited long-term adherence to therapy, as CPAP and MAD require permanent usage to avoid recurrence of the symptoms and adverse ill health. Read More

PLoS One 2019 22;14(5):e0216607. Epub 2019 May 22.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Background: This study aims to investigate the role of FPR 1/2/3 expressions in patients with obstructive sleep apnea (OSA).

Method: We made cross-sectional comparisons of FPR1/2/3 expressions of blood neutrophil, M1/M2a monocyte, and natural killer (NK) cell between 16 healthy subjects (HS), 16 primary snoring (PS) subjects, 46 treatment-naive OSA patients, and 18 severe OSA patients under long-term continuous positive airway pressure treatment (severe OSA on CPAP).

Results: FPR1 expressions on neutrophil were increased in treatment-naive OSA and severe OSA on CPAP groups versus either HS or PS. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Apr;33(4):313-318

Department of Sleep and Disorders, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510655, China.

This study was designed to show the preliminary efficacy and safety of the improved tongue base suspension surgery in severe obstructive sleep apnea(OSA) patients classified as Friedman Ⅱand Friedman Ⅲ. The severe OSA patients diagnosed by PSG as Friedman Ⅱ type and Ⅲ type underwent surgery treatment. The tongue base of the patient was implanted with titanium plate and fixed on the chin of mandible. Read More

Sleep Med 2019 05 31;57:61-69. Epub 2019 Jan 31.

Department of Radiology, Assaf Harofeh Medical Center, Zerifin, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objectives: To assess the effects of continuous positive airway pressure (CPAP) treatment on brain structure and function in patients with obstructive sleep apnea (OSA).

Methods: A prospective study of seven OSA patients recruited from the sleep center at our institution was carried out. Patients were treated with six weeks of CPAP treatment. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Feb;33(2):118-122

Department of Otorhinolaryngology Head and Neck Surgery,the Second Hospital of Hebei Medical University,Shijiazhuang, 050000, China.

To investigate the optimal position in application of acoustic pharyngometry to detect the pharyngeal condition and to assess its therapeutic effect on obstructive sleep apnea hypopnea syndrome(OSAHS). Eight adult males were assigned to the normal group, and 57 male patients with OSAHS diagnosed by polysomnograhy(PSG) were assigned to the snoring group. Of the snoring group, 11 patients who were diagnosed severe OSAHS underwent low-temperature plasma uvulopaltopharyngoplasty(UPPP) and coblationchanneling of the tongue(CCT), were assigned to the operation subgroup; 8 patients underwent continuous positive airway pressure(CPAP), which was assigned to the CPAP subgroup. Read More

Praxis (Bern 1994) 2019 Jan;108(2):111-117

1 Universitätsspital Zürich, Klinik für Pneumologie und Zentrum für Schlafmedizin, Zürich.

Obstructive Sleep Apnea Syndrome Abstract. The obstructive sleep apnea syndrome (OSAS) is a disorder of the control of breathing in which repetitive collapse of the upper airway during sleep leads to frequent apneas/hypopneas with cyclic oxygen desaturation and arousals. Sleep is fragmented and unrefreshing. Read More

Adv Exp Med Biol 2019 ;1153:11-17

Department of Prosthodontics, Warsaw Medical University, Warsaw, Poland.

Obstructive sleep apnea (OSA) is a sleep disorder resulting from the repetitive narrowing and collapse of the upper respiratory tract. The results of previous epidemiological studies confirm a significant impact of OSA on the health situation around the world. Untreated OSA is associated with many adverse health effects, such as hypertension, coronary artery disease, stroke, atrial fibrillation, congestive heart failure, and daytime sleepiness. Read More

Sleep Health 2019 02 13;5(1):91-100. Epub 2018 Nov 13.

Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia.

Objectives: To investigate whether in-home screening for obstructive sleep apnoea (OSA) promotes healthcare-seeking or lifestyle modification behaviour. We also examined the uptake and adherence rates to different treatment options, the factors affecting adherence, and the impact of treatment on health-related quality of life.

Design: Follow-up survey of adults at high risk of OSA. Read More

J Clin Sleep Med 2019 01 15;15(1):149-152. Epub 2019 Jan 15.

Division of Respiratory Diseases, Boston Children's Hospital, Boston, Massachusetts.

Abstract: Laryngomalacia is a common cause of chronic noisy breathing that can present as stridor in infants and neonates. Mild cases of laryngomalacia are usually followed clinically and managed conservatively. However, the evaluation and diagnosis could be challenging in some patients. Read More

Respir Care 2019 Jan;64(1):77-84

Department of Clinical Neurophysiology, Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland.

Background: Obesity is one of the most prominent risk factors for obstructive sleep apnea (OSA). Weight loss decreases the number of shorter respiratory events (<40 s), whereas the number of longer events remains almost unchanged. However, it is unknown how body mass index (BMI) affects individual obstruction event severity within OSA severity categories when age, sex, smoking, daytime sleepiness, snoring, hypertension, heart failure, and sleeping posture are considered. Read More

Ann Otol Rhinol Laryngol 2019 Mar 21;128(3):249-262. Epub 2018 Dec 21.

Division of Pulmonary, Critical Care and Sleep Medicine, The University of Utah, Salt Lake City, UT, USA.

Objective: Obstructive sleep apnea (OSA) is characterized by frequent interruptions in breathing related to upper airway collapse during sleep and may adversely affect phonatory function. This study aimed to: (1) establish the prevalence, risks, and quality of life burden of voice disorders in OSA and (2) explore the relation between voice disorders and positive airway pressure (PAP) therapy.

Study Design: Cross-sectional, descriptive epidemiology study. Read More

Sleep Sci 2018 May-Jun;11(3):160-165

Hospital Alemán, Sleep Units - Buenos Aires City - Buenos Aires - Argentina.

Purpose: Obstructive Sleep Apnea-Hypopnea Syndrome (OSAS) is a public health problem. We designed a pilot study to validate empiric indication of CPAP therapy in a population with moderate-to-high pre-test probabilities who underwent self-administered home-based respiratory polygraphy (RP).

Methods: A cross-sectional simulation study was performed. Read More

Tunis Med 2018 Aug - Sep;96(8-9):477-482

Background: Smoking is an established risk factor of several respiratory and extra respiratory diseases. However, the effect of smoking on obstructive sleep apnea syndrome (OSAS) is not well characterized. The purpose of this work is to study the influence of smoking on the severity of OSAS. Read More

Wiad Lek 2018;71(6):1254-1261

1 Oddział Elektrokardiologii, Górnośląskie Centrum Medyczne Im. Prof. Leszka Gieca Śląskiego Uniwersytetu Medycznego W Katowicach, Katowice, Polska, Klinika Elektrokardiologii I Niewydolności Serca Śląskiego Uniwersytetu Medycznego W Katowicach, Katowice, Polska.

Obstructive sleep apnea syndrome (OSAS) is caused by periodical upper airway occlusion during sleep resulting in snoring, episodes of apnea and excessive daytime sleepiness. OSAS is a risk factor for hypertension, arrhythmias, conduction disorders as well as stroke, coronary artery disease, chronic heart failure and pulmonary hypertension. Early polygraphy and polysomnography and continuous positive airway pressure (CPAP) treatment reduce risks of cardiovascular diseases (CVD) in patients with OSAS. Read More

J Postgrad Med 2019 Jan-Mar;65(1):47-49

Department of Otolaryngology, Head and Neck Surgery, Gulhane Medical School, Ankara, Turkey.

A 44-year-old male patient was admitted to the otolaryngology department with a history of progressive snoring, excessive daytime sleepiness, and reduced libido for the last 6 months. Polysomnography demonstrated the presence of moderate obstructive sleep apnea (OSA) with an apnea-hypopnea index (AHI) of 24.6 events/h, consisting of 77 obstructive and 59 central apneas. Read More

Pediatr Radiol 2018 08 4;48(9):1223-1233. Epub 2018 Aug 4.

Department of Radiology, Stanford University, Stanford, CA, USA.

Sleep-disordered breathing has a spectrum of severity that spans from snoring and partial airway collapse with increased upper airway resistance, to complete upper airway obstruction with obstructive sleep apnea during sleeping. While snoring occurs in up to 20% of children, obstructive sleep apnea affects approximately 1-5% of children. The obstruction that occurs in obstructive sleep apnea is the result of the airway collapsing during sleep, which causes arousal and impairs restful sleep. Read More

Respirology 2018 11 10;23(11):1055-1062. Epub 2018 Jul 10.

Division of Respiratory Medicine, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Princes of Wales Hospital, Shatin, Hong Kong, China.

Background And Objective: Unrecognized obstructive sleep apnoea syndrome (OSAS) may lead to poor asthma control despite optimal therapy. We assessed asthma control, airway responsiveness, daytime sleepiness and health status at baseline and 3 months after continuous positive airway pressure (CPAP) treatment among asthma patients with nocturnal symptoms and OSAS.

Methods: Patients with nocturnal asthma symptoms despite receiving at least moderate-dose inhaled corticosteroid and long-acting bronchodilators underwent a home sleep study using 'Embletta' portable diagnostic system. Read More

Otolaryngol Clin North Am 2018 Oct 20;51(5):1003-1009. Epub 2018 Jun 20.

Department of Otolaryngology-Head and Neck Surgery, Weill Cornell Medical College, 1305 York Avenue, 5th Floor, New York, NY 10021, USA. Electronic address:

Obstructive sleep apnea (OSA) is a highly prevalent condition in the context of the global obesity epidemic with significant medical comorbidities and psychosocial implications. The first-line treatment of OSA is continuous positive airway pressure (CPAP). There is evidence to demonstrate an association between nasal obstruction and OSA. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2018;118(5):14-17

Sverzhevsky Research and Clinical Center of Otorhinolaryngology, Moscow, Russia.

Aim: To explore the possibility of cerebral hemodynamic reserve (CHR) normalization in patients with obstructive sleep apnea syndrome (OSAS), aged over fifty, who received continuous positive airway pressure (CPAP) therapy.

Material And Methods: The main group (20 patients, aged 50-65 years, with severe OSAS) and the control group (20 volunteers without snoring and OSAS matched for age and physical status) were studied. Diagnosis included cardio-respiratory monitoring of nocturnal sleep and ultrasound examination of cerebral blood flow with functional tests (breath holding and hyperventilation) and calculating the coefficient of vasomotor reactivity (CVMR) before the start of CPAP-therapy and after one month therapy. Read More

Eur Arch Otorhinolaryngol 2018 Jul 28;275(7):1913-1919. Epub 2018 May 28.

Department of Otorhinolaryngology, Head and Neck Surgery, University-Hospital Mannheim, Mannheim, Germany.

Purpose: Upper airway stimulation (UAS) is an alternative second-line treatment option for patients with obstructive sleep apnea (OSA). In our substudy of a previous multicentre study of patients implanted with UAS, we focused on patient-related outcomes like Epworth Sleepiness Scale (ESS), the Functional Outcomes of Sleep Questionnaire (FOSQ), snoring and personal satisfaction 6 and 12 months after the implantation.

Methods: 60 patients, who were initially non-adherent to CPAP and implanted with UAS, were included in a prospective multicentre study. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Nov;31(21):1671-1675;1680

Department of Otorhinolarynglogy,Yidu Central Hospital, Weifang Medical College,Qingzhou, 262500, China.

To study the relationship between symptoms and sleep staging in OSAHS patients.A cross-sectional study. Adult subjects who attended a sleep laboratory for diagnostic polysomnography for a period of 1 month were recruited consecutively. Read More

Otolaryngol Clin North Am 2018 Aug 17;51(4):827-833. Epub 2018 May 17.

Department of Otolaryngology-Head and Neck Surgery, Weill Cornell Medicine, New York Presbyterian Hospital, 1305 York Avenue, New York, NY 10021, USA. Electronic address:

Older adults undergo gradual changes in their sleep patterns. It is important to differentiate normal age-related sleep changes from sleep disorders. Because sleep disorders can impact an older adult's day-to-day life and contribute to various comorbidities, these patients should be carefully screened by using a detailed medical history, combined with a detailed sleep history. Read More

Med Hypotheses 2018 Jun 10;115:81-86. Epub 2018 Apr 10.

University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania; National Institute of Respiratory Diseases "Marius Nasta", Bucharest, Romania.

Introduction: Obstructive sleep apnea syndrome (OSAS) is defined by recurrent episodes of significant reduction or absence of the oro-nasal airflow during sleep, in the presence of thorax and abdominal movements and snoring. The pathophysiological consequences of intermittent hypoxia determined by OSAS are represented by systemic inflammation, the release of free oxygen radicals and activation of the sympathetic nervous system. Cardiac arrhythmias are a frequent comorbidity in patients with OSAS. Read More

J Diabetes Investig 2018 Sep 14;9(5):991-997. Epub 2018 Apr 14.

Department of Public Health, Graduate School of Juntendo University, Tokyo, Japan.

The aim of the present review was to clarify the association between obstructive sleep apnea (OSA) and type 2 diabetes, and discuss the therapeutic role of continuous positive airway pressure (CPAP) in type 2 diabetes. OSA patients are more likely than non-OSA populations to develop type 2 diabetes, while more than half of type 2 diabetes patients suffer from OSA. Similar to Western countries, in the East Asian population, the association between these two disorders has also been reported. Read More

Monaldi Arch Chest Dis 2017 12 5;87(3):822. Epub 2017 Dec 5.

University of Bari "Aldo Moro", Department of Emergency and Organ Transplantation.

Recently, it has been clearly described an independent relationship between obstructive sleep apnea syndrome (OSAS) and cardiovascular risk, with underlying mechanisms also including endothelial dysfunction. We enrolled 32 consecutive non-obese patients (mean age of 39.5±11. Read More

Eur J Clin Invest 2018 May 3;48(5):e12908. Epub 2018 Mar 3.

Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.

Background: Previous studies suggested obstructive sleep apnoea syndrome (OSAS) as a major risk factor for incident cardiovascular events. However, the relationship between OSAS severity, the use of continuous positive airway pressure (CPAP) treatment and the development of cardiovascular disease is still matter of debate.

Study Objectives: The aim was to test the association between OSAS and cardiovascular events in patients with concomitant cardio-metabolic diseases and the potential impact of CPAP therapy on cardiovascular outcomes. Read More

Cureus 2017 Oct 24;9(10):e1800. Epub 2017 Oct 24.

Department of Neurology, University of Missouri, Columbia, Missouri.

Obstructive sleep apnea (OSA), an increasingly prevalent sleep disorder, has been extensively studied in both clinical and scientific settings. In most cases, the diagnosis of sleep apnea is straightforward with patients having symptoms of snoring, choking or gasping for air while asleep and witnessed apneas. However, sleep apnea is known to present in some unusual ways. Read More

J Pediatr 2018 04 23;195:102-107.e1. Epub 2017 Dec 23.

Sleep Research Center, Oasi Research Institute IRCCS, Troina, Italy.

Introduction: To evaluate the effect of continuous positive airway pressure (CPAP) treatment on blood pressure (BP) in children with obstructive sleep apnea (OSA).

Study Design: Retrospective chart review of children aged 7-17 referred to Benioff Children's Hospital Oakland for the evaluation of snoring. Data collected included age, body mass index (BMI), BP, heart rate, apnea-hypopnea index, and oxygen saturation nadir. Read More

Ann Otol Rhinol Laryngol 2018 Feb 25;127(2):118-123. Epub 2017 Dec 25.

2 Sleep Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Objective: To retrospectively study the effects of minimally invasive single-stage multilevel surgery (MISS MLS) for treating patients with obstructive sleep apnea/hypopnea syndrome (OSA) on quality of life (QOL).

Methods: All OSA patients with multilevel obstruction who failed or refused continuous positive airway pressure (CPAP) treatment and then underwent Pillar implants and temperature-controlled radiofrequency of the base of tongue (RFBOT) were enrolled. The subjective symptoms and QOL (SF-36 Taiwan Standard Version 1. Read More

Acta Clin Belg 2018 Jun 20;73(3):191-198. Epub 2017 Nov 20.

a Pneumology Department and Center for Sleep Medicine , Cliniques Universitaires Saint Luc , Brussels , Belgium.

Purpose of the study Periodic leg movements (PLMs) are found in 30% of patients suffering from OSA. Under CPAP, we observed that PLMs can increase, decrease, or remain unchanged. The predictors of these changes are not well established. Read More

Chron Respir Dis 2018 05 8;15(2):157-164. Epub 2017 Nov 8.

1 Department of Respiratory Medicine, Zhongshan Hospital, Xiamen University, Xiamen, Fujian, China.

The aims of this article were to determine the levels of serum high-sensitivity cardiac troponin T (hs-cTnT) in obstructive sleep apnea (OSA) patients without cardiovascular disease (CVD) and to assess the efficacy of continuous positive airway pressure (CPAP). Snorers referred for polysomnography (PSG) for the investigation of OSA were eligible and hs-cTnT levels measured in our pilot study. Hs-cTnT was measured again after 3 months of CPAP treatment in participants with severe OSA. Read More

Intern Med J 2017 Nov;47(11):1241-1247

Centre for Sleep Health and Research, Department of Respiratory Medicine, Royal North Shore Hospital, Sydney, New South Wales, Australia.

The term sleep disordered breathing encompasses a spectrum of abnormalities, including snoring, obstructive sleep apnoea (OSA), central sleep apnoea (CSA), respiratory-related arousals and hypoventilation. This review focuses on both OSA and CSA. It provides a clinical update of recent advances in the diagnosis, management and prognosis of these two conditions. Read More