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J Clin Sleep Med 2019 Jan 3. Epub 2019 Jan 3.

Abstract: Laryngomalacia is a common cause of chronic noisy breathing that can present as stridor in infants and neonates. Mild cases of laryngomalacia are usually followed clinically and managed conservatively. However, the evaluation and diagnosis could be challenging in some patients. Read More

Respir Care 2019 Jan;64(1):77-84

Department of Clinical Neurophysiology, Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland.

Background: Obesity is one of the most prominent risk factors for obstructive sleep apnea (OSA). Weight loss decreases the number of shorter respiratory events (<40 s), whereas the number of longer events remains almost unchanged. However, it is unknown how body mass index (BMI) affects individual obstruction event severity within OSA severity categories when age, sex, smoking, daytime sleepiness, snoring, hypertension, heart failure, and sleeping posture are considered. Read More

Ann Otol Rhinol Laryngol 2018 Dec 21:3489418819541. Epub 2018 Dec 21.

3 Division of Pulmonary, Critical Care and Sleep Medicine, The University of Utah, Salt Lake City, UT, USA.

Objective:: Obstructive sleep apnea (OSA) is characterized by frequent interruptions in breathing related to upper airway collapse during sleep and may adversely affect phonatory function. This study aimed to: (1) establish the prevalence, risks, and quality of life burden of voice disorders in OSA and (2) explore the relation between voice disorders and positive airway pressure (PAP) therapy.

Study Design:: Cross-sectional, descriptive epidemiology study. Read More

Sleep Sci 2018 May-Jun;11(3):160-165

Hospital Alemán, Sleep Units - Buenos Aires City - Buenos Aires - Argentina.

Purpose: Obstructive Sleep Apnea-Hypopnea Syndrome (OSAS) is a public health problem. We designed a pilot study to validate empiric indication of CPAP therapy in a population with moderate-to-high pre-test probabilities who underwent self-administered home-based respiratory polygraphy (RP).

Methods: A cross-sectional simulation study was performed. Read More

Tunis Med 2018 Aug - Sep;96(8-09):477-482

Background: Smoking is an established risk factor of several respiratory and extra respiratory diseases. However, the effect of smoking on obstructive sleep apnea syndrome (OSAS) is not well characterized. The purpose of this work is to study the influence of smoking on the severity of OSAS. Read More

Wiad Lek 2018;71(6):1254-1261

1 Oddział Elektrokardiologii, Górnośląskie Centrum Medyczne Im. Prof. Leszka Gieca Śląskiego Uniwersytetu Medycznego W Katowicach, Katowice, Polska, Klinika Elektrokardiologii I Niewydolności Serca Śląskiego Uniwersytetu Medycznego W Katowicach, Katowice, Polska.

Obstructive sleep apnea syndrome (OSAS) is caused by periodical upper airway occlusion during sleep resulting in snoring, episodes of apnea and excessive daytime sleepiness. OSAS is a risk factor for hypertension, arrhythmias, conduction disorders as well as stroke, coronary artery disease, chronic heart failure and pulmonary hypertension. Early polygraphy and polysomnography and continuous positive airway pressure (CPAP) treatment reduce risks of cardiovascular diseases (CVD) in patients with OSAS. Read More

J Postgrad Med 2018 Aug 24. Epub 2018 Aug 24.

Department of Otolaryngology, Head and Neck Surgery, Gulhane Medical School, Ankara, Turkey.

A 44-year-old male patient was admitted to the otolaryngology department with a history of progressive snoring, excessive daytime sleepiness, and reduced libido for the last 6 months. Polysomnography demonstrated the presence of moderate obstructive sleep apnea (OSA) with an apnea-hypopnea index (AHI) of 24.6 events/h, consisting of 77 obstructive and 59 central apneas. Read More

Pediatr Radiol 2018 08 4;48(9):1223-1233. Epub 2018 Aug 4.

Department of Radiology, Stanford University, Stanford, CA, USA.

Sleep-disordered breathing has a spectrum of severity that spans from snoring and partial airway collapse with increased upper airway resistance, to complete upper airway obstruction with obstructive sleep apnea during sleeping. While snoring occurs in up to 20% of children, obstructive sleep apnea affects approximately 1-5% of children. The obstruction that occurs in obstructive sleep apnea is the result of the airway collapsing during sleep, which causes arousal and impairs restful sleep. Read More

Respirology 2018 Nov 10;23(11):1055-1062. Epub 2018 Jul 10.

Division of Respiratory Medicine, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Princes of Wales Hospital, Shatin, Hong Kong, China.

Background And Objective: Unrecognized obstructive sleep apnoea syndrome (OSAS) may lead to poor asthma control despite optimal therapy. We assessed asthma control, airway responsiveness, daytime sleepiness and health status at baseline and 3 months after continuous positive airway pressure (CPAP) treatment among asthma patients with nocturnal symptoms and OSAS.

Methods: Patients with nocturnal asthma symptoms despite receiving at least moderate-dose inhaled corticosteroid and long-acting bronchodilators underwent a home sleep study using 'Embletta' portable diagnostic system. Read More

Otolaryngol Clin North Am 2018 Oct 20;51(5):1003-1009. Epub 2018 Jun 20.

Department of Otolaryngology-Head and Neck Surgery, Weill Cornell Medical College, 1305 York Avenue, 5th Floor, New York, NY 10021, USA. Electronic address:

Obstructive sleep apnea (OSA) is a highly prevalent condition in the context of the global obesity epidemic with significant medical comorbidities and psychosocial implications. The first-line treatment of OSA is continuous positive airway pressure (CPAP). There is evidence to demonstrate an association between nasal obstruction and OSA. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2018;118(5):14-17

Sverzhevsky Research and Clinical Center of Otorhinolaryngology, Moscow, Russia.

Aim: To explore the possibility of cerebral hemodynamic reserve (CHR) normalization in patients with obstructive sleep apnea syndrome (OSAS), aged over fifty, who received continuous positive airway pressure (CPAP) therapy.

Material And Methods: The main group (20 patients, aged 50-65 years, with severe OSAS) and the control group (20 volunteers without snoring and OSAS matched for age and physical status) were studied. Diagnosis included cardio-respiratory monitoring of nocturnal sleep and ultrasound examination of cerebral blood flow with functional tests (breath holding and hyperventilation) and calculating the coefficient of vasomotor reactivity (CVMR) before the start of CPAP-therapy and after one month therapy. Read More

Eur Arch Otorhinolaryngol 2018 Jul 28;275(7):1913-1919. Epub 2018 May 28.

Department of Otorhinolaryngology, Head and Neck Surgery, University-Hospital Mannheim, Mannheim, Germany.

Purpose: Upper airway stimulation (UAS) is an alternative second-line treatment option for patients with obstructive sleep apnea (OSA). In our substudy of a previous multicentre study of patients implanted with UAS, we focused on patient-related outcomes like Epworth Sleepiness Scale (ESS), the Functional Outcomes of Sleep Questionnaire (FOSQ), snoring and personal satisfaction 6 and 12 months after the implantation.

Methods: 60 patients, who were initially non-adherent to CPAP and implanted with UAS, were included in a prospective multicentre study. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Nov;31(21):1671-1675;1680

Department of Otorhinolarynglogy,Yidu Central Hospital, Weifang Medical College,Qingzhou, 262500, China.

To study the relationship between symptoms and sleep staging in OSAHS patients.A cross-sectional study. Adult subjects who attended a sleep laboratory for diagnostic polysomnography for a period of 1 month were recruited consecutively. Read More

Otolaryngol Clin North Am 2018 Aug 17;51(4):827-833. Epub 2018 May 17.

Department of Otolaryngology-Head and Neck Surgery, Weill Cornell Medicine, New York Presbyterian Hospital, 1305 York Avenue, New York, NY 10021, USA. Electronic address:

Older adults undergo gradual changes in their sleep patterns. It is important to differentiate normal age-related sleep changes from sleep disorders. Because sleep disorders can impact an older adult's day-to-day life and contribute to various comorbidities, these patients should be carefully screened by using a detailed medical history, combined with a detailed sleep history. Read More

Med Hypotheses 2018 Jun 10;115:81-86. Epub 2018 Apr 10.

University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania; National Institute of Respiratory Diseases "Marius Nasta", Bucharest, Romania.

Introduction: Obstructive sleep apnea syndrome (OSAS) is defined by recurrent episodes of significant reduction or absence of the oro-nasal airflow during sleep, in the presence of thorax and abdominal movements and snoring. The pathophysiological consequences of intermittent hypoxia determined by OSAS are represented by systemic inflammation, the release of free oxygen radicals and activation of the sympathetic nervous system. Cardiac arrhythmias are a frequent comorbidity in patients with OSAS. Read More

J Diabetes Investig 2018 Sep 14;9(5):991-997. Epub 2018 Apr 14.

Department of Public Health, Graduate School of Juntendo University, Tokyo, Japan.

The aim of the present review was to clarify the association between obstructive sleep apnea (OSA) and type 2 diabetes, and discuss the therapeutic role of continuous positive airway pressure (CPAP) in type 2 diabetes. OSA patients are more likely than non-OSA populations to develop type 2 diabetes, while more than half of type 2 diabetes patients suffer from OSA. Similar to Western countries, in the East Asian population, the association between these two disorders has also been reported. Read More

Monaldi Arch Chest Dis 2017 Dec 5;87(3):822. Epub 2017 Dec 5.

University of Bari "Aldo Moro", Department of Emergency and Organ Transplantation.

Recently, it has been clearly described an independent relationship between obstructive sleep apnea syndrome (OSAS) and cardiovascular risk, with underlying mechanisms also including endothelial dysfunction. We enrolled 32 consecutive non-obese patients (mean age of 39.5±11. Read More

Eur J Clin Invest 2018 May 3;48(5):e12908. Epub 2018 Mar 3.

Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.

Background: Previous studies suggested obstructive sleep apnoea syndrome (OSAS) as a major risk factor for incident cardiovascular events. However, the relationship between OSAS severity, the use of continuous positive airway pressure (CPAP) treatment and the development of cardiovascular disease is still matter of debate.

Study Objectives: The aim was to test the association between OSAS and cardiovascular events in patients with concomitant cardio-metabolic diseases and the potential impact of CPAP therapy on cardiovascular outcomes. Read More

Cureus 2017 Oct 24;9(10):e1800. Epub 2017 Oct 24.

Department of Neurology, University of Missouri, Columbia, Missouri.

Obstructive sleep apnea (OSA), an increasingly prevalent sleep disorder, has been extensively studied in both clinical and scientific settings. In most cases, the diagnosis of sleep apnea is straightforward with patients having symptoms of snoring, choking or gasping for air while asleep and witnessed apneas. However, sleep apnea is known to present in some unusual ways. Read More

J Pediatr 2018 Apr 23;195:102-107.e1. Epub 2017 Dec 23.

Sleep Research Center, Oasi Research Institute IRCCS, Troina, Italy.

Introduction: To evaluate the effect of continuous positive airway pressure (CPAP) treatment on blood pressure (BP) in children with obstructive sleep apnea (OSA).

Study Design: Retrospective chart review of children aged 7-17 referred to Benioff Children's Hospital Oakland for the evaluation of snoring. Data collected included age, body mass index (BMI), BP, heart rate, apnea-hypopnea index, and oxygen saturation nadir. Read More

Ann Otol Rhinol Laryngol 2018 Feb 25;127(2):118-123. Epub 2017 Dec 25.

2 Sleep Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Objective: To retrospectively study the effects of minimally invasive single-stage multilevel surgery (MISS MLS) for treating patients with obstructive sleep apnea/hypopnea syndrome (OSA) on quality of life (QOL).

Methods: All OSA patients with multilevel obstruction who failed or refused continuous positive airway pressure (CPAP) treatment and then underwent Pillar implants and temperature-controlled radiofrequency of the base of tongue (RFBOT) were enrolled. The subjective symptoms and QOL (SF-36 Taiwan Standard Version 1. Read More

Acta Clin Belg 2018 Jun 20;73(3):191-198. Epub 2017 Nov 20.

a Pneumology Department and Center for Sleep Medicine , Cliniques Universitaires Saint Luc , Brussels , Belgium.

Purpose of the study Periodic leg movements (PLMs) are found in 30% of patients suffering from OSA. Under CPAP, we observed that PLMs can increase, decrease, or remain unchanged. The predictors of these changes are not well established. Read More

Chron Respir Dis 2018 May 8;15(2):157-164. Epub 2017 Nov 8.

1 Department of Respiratory Medicine, Zhongshan Hospital, Xiamen University, Xiamen, Fujian, China.

The aims of this article were to determine the levels of serum high-sensitivity cardiac troponin T (hs-cTnT) in obstructive sleep apnea (OSA) patients without cardiovascular disease (CVD) and to assess the efficacy of continuous positive airway pressure (CPAP). Snorers referred for polysomnography (PSG) for the investigation of OSA were eligible and hs-cTnT levels measured in our pilot study. Hs-cTnT was measured again after 3 months of CPAP treatment in participants with severe OSA. Read More

Intern Med J 2017 Nov;47(11):1241-1247

Centre for Sleep Health and Research, Department of Respiratory Medicine, Royal North Shore Hospital, Sydney, New South Wales, Australia.

The term sleep disordered breathing encompasses a spectrum of abnormalities, including snoring, obstructive sleep apnoea (OSA), central sleep apnoea (CSA), respiratory-related arousals and hypoventilation. This review focuses on both OSA and CSA. It provides a clinical update of recent advances in the diagnosis, management and prognosis of these two conditions. Read More

Ther Adv Respir Dis 2017 11 23;11(11):411-423. Epub 2017 Oct 23.

Department of Otolaryngology, Royal National Throat, Nose & Ear Hospital, 330 Grays Inn Road, London WC1X 8DA, UK.

Snoring and obstructive sleep apnoea (OSA) are increasingly common conditions, and confer a significant health and socioeconomic burden. Furthermore, untreated OSA represents a significant mortality risk. Patients require careful assessment, including detailed clinical history and examination, sleep study and drug-induced sleep endoscopy (DISE). Read More

Sleep Med 2017 Oct 22;38:17-20. Epub 2017 Jul 22.

Department of Neurosciences, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon, Portugal; EEG/Sleep Laboratory, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon, Portugal; Faculty of Medicine, Lisbon University, Lisbon, Portugal.

Objective: The association between restless legs syndrome (RLS) and obstructive sleep apnea syndrome (OSAS) has seldom been reported. There is one study reporting improvement of RLS symptoms severity in patients naive of treatment after initiation of continuous positive airway pressure (CPAP) for OSAS. The aim of this study was to evaluate the impact of the OSAS treatment in patients with previously diagnosed, clinically significant RLS in a usual clinical setting. Read More

Respirology 2017 11 12;22(8):1500-1507. Epub 2017 Sep 12.

Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine and Veterans Administration Pittsburgh Health System, Pittsburgh, PA, USA.

Continuous positive airway pressure (CPAP) is the standard treatment for moderate-to-severe obstructive sleep apnoea (OSA). However, adherence to CPAP is limited and non-CPAP therapies are frequently explored. Oral appliance (OA) therapy is currently widely used for the treatment of snoring, mild, moderate and severe OSA. Read More

FP Essent 2017 Sep;460:11-21

Latterman Family Health Center, 2347 Fifth Ave, McKeesport, PA 15132.

Sleep-related breathing disorders or sleep-disordered breathing are characterized by abnormal respiration during sleep. They are grouped into obstructive sleep apnea (OSA), central sleep apnea, sleep-related hypoventilation, and sleep-related hypoxemia disorder. OSA is a common disorder encountered in the family medicine setting that is increasingly being recognized because of the obesity epidemic and greater public and physician awareness. Read More

An Pediatr (Barc) 2018 May 24;88(5):266-272. Epub 2017 Aug 24.

Servicio de Cirugía General y del Aparato Digestivo, Hospital Universitario La Paz, Madrid, España.

Introduction: Obstructive sleep apnoea (OSA) is highly prevalent in children and a major public health problem. An attempt is made to determine the clinical and polysomnographic presentation of paediatric OSA in our area.

Patients And Methods: Retrospective descriptive study of sleep tests conducted on children up to 14 years-old from 1999 to 2012 in the Sleep Unit of the University Hospital of Albacete. Read More

Adv Otorhinolaryngol 2017 17;80:66-73. Epub 2017 Jul 17.

Numerous studies report that difficulty breathing through the nose is associated with reduced sleep quality, increased daytime dysfunction, and increased risk of snoring and obstructive sleep apnea (OSA). Additionally, chronic nasal obstruction often complicates and limits successful medical device therapy for OSA, particularly with continuous positive airway pressure (CPAP). When medical evaluation and management of the nose is inadequate, surgical therapy to lower nasal resistance has been shown to substantially improve sleep and breathing outcome measures. Read More

Aust Fam Physician 2017 ;46(7):460-463

Background: Obstructive sleep apnoea (OSA) and obesity are two common conditions affecting the Australian population; obesity is the major risk factor for OSA.

Objective: The objectives of this article are to review the interactions between obesity and OSA, including the increased cardiovascular risk, and highlight the importance of using OSA diagnosis as a critical time to address obesity itself and other cardiovascular risk factors.

Discussion: Snoring and symptoms of OSA frequently worsen during periods of rapid weight gain. Read More

Monaldi Arch Chest Dis 2017 May 18;87(1):766. Epub 2017 May 18.

Maugeri Clinical Scientific Institutes, Respiratory Rehabilitation Division.

The obstructive sleep apnoea syndrome (OSAS) may be associated with several eyes disorders, among which the most common is the floppy eyelid syndrome (FES). We intended to highlight the association between OSAS and FES and evaluate the effect of FES treatment with Continuous Positive Airway Pressure (CPAP). A 50-year patient with a 10-year history of snoring, sleep fragmentation and daytime sleepiness associated with several comorbidities has been studied. Read More

Sleep Med 2017 Jun 10;34:13-17. Epub 2017 Mar 10.

Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan.

Objective/background: Multiple system atrophy (MSA) frequently results in the development of sleep-disordered breathing (SDB). Few reports have described the natural course of this phenomenon. The aim of the present study was to determine the natural course of SDB and prognostic factors associated with such conditions in MSA. Read More

PLoS One 2017 17;12(5):e0176575. Epub 2017 May 17.

Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

We aimed to identify novel molecular associations between chronic intermittent hypoxia with re-oxygenation and adverse consequences in obstructive sleep apnea (OSA). We analyzed gene expression profiles of peripheral blood mononuclear cells from 48 patients with sleep-disordered breathing stratified into four groups: primary snoring (PS), moderate to severe OSA (MSO), very severe OSA (VSO), and very severe OSA patients on long-term continuous positive airway pressure treatment (VSOC). Comparisons of the microarray gene expression data identified eight genes up-regulated with OSA and down-regulated with CPAP treatment, and five genes down-regulated with OSA and up-regulated with CPAP treatment. Read More

Respirology 2017 07 5;22(5):849-860. Epub 2017 May 5.

Division of Sleep Medicine/Department of Medicine, Center for Sleep and Circadian Neurobiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

P4 medicine is an evolving approach to personalized medicine. The four Ps offer a means to: Predict who will develop disease and co-morbidities; Prevent rather than react to disease; Personalize diagnosis and treatment; have patients Participate in their own care. P4 medicine is very applicable to obstructive sleep apnoea (OSA) because each OSA patient has a different pathway to disease and its consequences. Read More

J Clin Sleep Med 2017 May 15;13(5):703-711. Epub 2017 May 15.

Johns Hopkins Sleep Disorders Center, Center for Interdisciplinary Sleep Research and Education, Baltimore, Maryland.

Study Objectives: To assess effects of low-level continuous positive airway pressure (CPAP) on snoring in habitual snorers without obstructive sleep apnea (OSA).

Methods: A multicenter prospective in-laboratory reversal crossover intervention trial was conducted between September 2013 and August 2014. Habitual snorers were included if they snored (inspiratory sound pressure level ≥ 40 dBA) for ≥ 30% all sleep breaths on a baseline sleep study (Night 1), and if significant OSA and daytime somnolence were absent. Read More

Sleep Sci 2016 Jul-Sep;9(3):244-248. Epub 2016 Nov 14.

Respiratory Medicine Service, Hospital Británico, Buenos Aires, Argentina.

Introduction: Obstructive sleep syndrome (OSA) is diagnosed through polysomnography (PSG) or respiratory polygraphy (RP). Self-administered home-based RP using devices with data transmission could facilitate diagnosis in distant populations. The purpose of this work was to describe a telemedicine initiative using RP in four satellite outpatient care clinics (OCC) of Buenos Aires Hospital Británico Central (HBC). Read More

HNO 2017 Feb;65(2):125-133

Schlafmedizinisches Zentrum, Universitäts-HNO-Klinik Mannheim, Mannheim, Deutschland.

Background: Drug-induced sedation endoscopy (DISE) is a diagnostic procedure which allows evaluation of the collapsibility of the upper airway. According to expert opinion, it is possible to imitate nocturnal collapsibility and perform a realistic investigation of the site of obstruction and vibration. This should enable sufficient and precise therapeutic advice to be given solely on the basis of clinical assessment. Read More

Zhonghua Jie He He Hu Xi Za Zhi 2017 Jan;40(1):46-51

State Key Laboratory of Respiratory Diseases, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Diseases, National Research Center of Clinical Medicine, Guangzhou 510120, China.

To study the relationship between dilated cardiomyopathy and obstructive sleep apnea-hypopnea syndrome (OSAHS) and to evaluate the curative effects of continuous positive airway pressure (CPAP) in OSAHS complicated with dilated cardiomyopathy. We reported one case with the symptom of exertional dyspnea for 1 year and aggravating for 1 month. The patient finally was diagnosed with severe OSAHS complicated with dilated cardiomyopathy leading to pulmonary hypertension. Read More

Rev Neurosci 2017 04;28(3):265-270

Obstructive sleep apnea syndrome (OSAS) is characterized by the recurrent cessation (apnea) or reduction (hypopnea) of airflow due to the partial or complete upper airway collapse during sleep. Respiratory disturbances causing sleep fragmentation and repetitive nocturnal hypoxia are responsible for a variety of nocturnal and daytime complaints of sleep apnea patients, such as snoring, daytime sleepiness, fatigue, or impaired cognitive functions. Different techniques, such as magnetic resonance imaging, magnetic resonance spectroscopy, and positron emission tomography, are used to evaluate the structural and functional changes in OSAS patients. Read More

Oral Dis 2017 Jul 24;23(5):629-635. Epub 2017 Mar 24.

Department of Oral Medicine, Sedation and Maxillofacial Imaging Hebrew University - Hadassah School of Dental Medicine, Jerusalem, Israel.

Objective: Oral appliances (OA) are recommended for patients with severe obstructive sleep apnea who fail to comply with continuous positive airway pressure (CPAP) therapy. This mixed-methods study aimed to quantify adherence to OA therapy and evaluate subjective reasons associated with non-adherence.

Materials And Methods: The medical records of 52 patients with an apnea-hypopnea index (AHI) ≥ 40, treated with OA after discontinuation of CPAP treatment, were examined for OA adherence. Read More

J Clin Diagn Res 2016 Nov 1;10(11):OC14-OC16. Epub 2016 Nov 1.

Resident, Department of Neurology, IPGMER, Bangur Institute of Neurosciences , Kolkata, West Bengal, India .

Introduction: Obstructive Sleep Apnoea (OSA) is a highly prevalent disease and a major public health issue in India. Excessive daytime sleepiness is an almost ubiquitous symptom of OSA. Epworth Sleepiness Scale (ESS) score is a validated objective score to measure the degree of daytime sleepiness. Read More

Turk Psikiyatri Derg 2016 ;27(4):244-250

Objective: The aim of this study is to determine the effects of continuous positive airway pressure (CPAP) treatment on depression, anxiety, and perceived stress levels and to identify factors predictive of treatment efficacy in patients with obstructive sleep apnea syndrome (OSAS).

Method: This study included 51 patients admitted to the Adiyaman University Medical School Otorhinolaryngology Department or Eskisehir Yunus Emre State Hospital between January and September 2014 with one or more complaints including snoring, excessive daytime sleepiness, or apnea witnessed by the partner. Diagnosis of OSAS was made by polysomnography and CPAP treatment was initiated. Read More

Laryngoscope 2017 07 21;127(7):E244-E250. Epub 2016 Dec 21.

Department of Medical Biochemistry, Dışkapı Yıldırım Bayezit Training and Research Hospital, Ankara, Turkey.

Objectives: The aim of the present study was to assess thiol/disulfide (SS) homeostasis as a novel indicator of oxidative stress in patients with obstructive sleep apnea (OSA) and to investigate the effect of continuous positive airway pressure (CPAP) therapy on oxidative parameters.

Study Design: Prospective clinical study.

Methods: A total of 104 subjects, 44 in an OSA group and 60 in two control groups (control simple snoring group, control OSA group) were included. Read More

Respirology 2017 02 20;22(2):217-229. Epub 2016 Dec 20.

Department of Respiratory Medicine, Alfred Hospital, Melbourne, Victoria, Australia.

Heart failure (HF) and sleep apnoea are common disorders which frequently coexist. Two main types of apnoea occur: one is obstructive which, through recurring episodes of snoring, hypoxaemia, large negative intra-thoracic pressures and arousals from sleep leading to downstream inflammatory and autonomic nervous system changes, is thought to be a causative factor to the development of systemic hypertension and HF. The other type of apnoea, Cheyne-Stokes respiration with central sleep apnoea (CSR-CSA), is characterized by an oscillatory pattern of ventilation with a prevailing hyperventilation-induced hypocapnia, often in the absence of significant hypoxaemia and snoring, and is thought to be a consequence of advanced HF-related low cardiac output, high sympathetic nervous system activation and pulmonary congestion. Read More

J Allergy Clin Immunol Pract 2017 May - Jun;5(3):628-639. Epub 2016 Dec 5.

SUNY Downstate Medical Center, Brooklyn, NY.

Background: Sleep-disordered breathing in general and obstructive sleep apnea in particular are commonly encountered conditions in allergy practice. Physiologically, nasal (or nasopharyngeal) obstruction from rhinitis, nasal polyposis, or adenotonsillar hypertrophy are credible contributors to snoring and nocturnal respiratory obstructive events. Nevertheless, existing practice parameters largely relegate the role of the allergist to adjunctive treatment in cases of continuous positive airway pressure intolerance. Read More

Sleep Breath 2017 May 2;21(2):387-395. Epub 2016 Dec 2.

Disciplina de Medicina e Biologia do Sono, Departamento de Psicobiologia, Universidade Federal de São Paulo, Rua Napoleao de Barros 925, São Paulo, SP, 04024-002, Brazil.

Purpose: Few studies have investigated myofunctional therapy in patients with obstructive sleep apnea syndrome (OSAS). The objective of this study was to evaluate the effect of myofunctional therapy on continuous positive airway pressure (CPAP) adherence.

Methods: The study was registered at ClinicalTrials. Read More

Adv Exp Med Biol 2017 ;944:63-71

Department of Prosthodontics, Medical University of Warsaw, Warsaw, Poland.

A combination of abnormal anatomy and physiology of the upper airway can produce its repetitive narrowing during sleep, resulting in obstructive sleep apnea (OSA). Treatment of sleep-breathing disorder ranges from lifestyle modifications, upper airway surgery, continuous positive airway pressure (CPAP) to the use of oral appliances. A proper treatment selection should be preceded by thorough clinical and instrumental examinations. Read More