5,695 results match your criteria Snakebite


Micrurus surinamensis Peruvian snake venom: Cytotoxic activity and purification of a C-type lectin protein (Ms-CTL) highly toxic to cardiomyoblast-derived H9c2 cells.

Int J Biol Macromol 2020 Aug 8. Epub 2020 Aug 8.

Departamento de Bioquímica e Imunologia, ICB, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, CEP: 31270-901 Belo Horizonte, Minas Gerais, Brazil. Electronic address:

Micrurus surinamensis (Cuvier, 1817), popularly known as aquatic coral snake, has a broad geographic distribution in the Rainforest of South America. The purpose of this study was to investigate the cytotoxic effect caused by M. surinamensis venom in H9c2 cardiomyoblast cells and to identify protein components involved in cardiotoxic processes. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.08.033DOI Listing

Analysis of wound exudates reveals differences in the patterns of tissue damage and inflammation induced by the venoms of Daboia russelii and Bothrops asper in mice.

Toxicon 2020 Aug 8. Epub 2020 Aug 8.

University of Virginia School of Medicine, Charlottesville, VA, 22908, USA. Electronic address:

Clinical manifestations of envenomings by bites of the viperid snakes Bothrops asper and Daboia russelii show marked differences. Both venoms elicit the typical effects induced by viperid venoms (local tissue damage, bleeding, coagulopathies, shock). In addition, envenomings by D. Read More

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http://dx.doi.org/10.1016/j.toxicon.2020.07.025DOI Listing

Adjunct treatment in snakebite envenoming: a systematic review of randomised controlled trials.

Trans R Soc Trop Med Hyg 2020 Aug 11. Epub 2020 Aug 11.

Department of Clinical Medicine, Faculty of Medicine, University of Colombo, CO008, Sri Lanka.

Adjunct therapy in snakebite may be lifesaving if administered appropriately or can be harmful if non-judicious use leads to avoidable delays in administering antivenom. This systematic review analyses the evidence from randomised controlled trials (RCTs) on the efficacy of adjunct treatment administered with antivenom. PubMed, EMBASE, Scopus, Cochrane library and CINAHL were searched for RCTs enrolling patients with snakebite envenoming where a treatment other than antivenom has been assessed for its efficacy within the last 25 y. Read More

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http://dx.doi.org/10.1093/trstmh/traa062DOI Listing

Asymmetrical expression of toxins between the left and right venom glands of an individual prairie rattlesnake (Crotalus viridis viridis).

Toxicon 2020 Aug 7. Epub 2020 Aug 7.

School of Biological Sciences, University of Northern Colorado, 501 20th Street, Greeley, CO, 80639-0017, USA. Electronic address:

It is assumed that toxin expression is equivalent between left and right glands of a single snake. In the current study, we report venoms that differ in enzyme functionality and overall composition between the left and right gland of a single snake. The right gland produced venom of comparable composition to venom previously extracted from the same individual; however, the left gland produced venom with overall lower protein content and considerably less enzyme activity. Read More

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http://dx.doi.org/10.1016/j.toxicon.2020.08.005DOI Listing

New insights into snakebite epidemiology in Costa Rica: A retrospective evaluation of medical records.

Toxicon X 2020 Sep 30;7:100055. Epub 2020 Jul 30.

Departamento de Farmacología y Toxicología, Escuela de Medicina, Universidad de Costa Rica, San José, Costa Rica.

Continuous monitoring of the snakebite envenoming allows elucidating factors that affect its incidence at spatial and temporal scales, and is a great tool to evaluate the proper management of snakebite in health centers. To determine if there have been changes over time in snakebite epidemiology in Costa Rica, we conducted a retrospective study using medical records from six hospitals for the years 2012-2013. A total of 475 snakebite patients were treated at the selected hospital during this period. Read More

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http://dx.doi.org/10.1016/j.toxcx.2020.100055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398977PMC
September 2020

Serum IgE against galactose-alpha-1,3-galactose is common in Laotian patients with snakebite envenoming but not the major trigger for early anaphylactic reactions to antivenom.

Toxicon X 2020 Sep 28;7:100054. Epub 2020 Jul 28.

Department of Dermatology and Allergy Biederstein, School of Medicine, Technical University of Munich, Munich, Germany.

Snake antivenom is the only specific treatment for snakebite envenoming, but life-threatening anaphylaxis is a severe side effect and drawback for the use of these typically mammalian serum products. The present study investigates the hypotheses whether serum IgE antibodies against the epitope galactose-alpha-1,3-galactose (α-gal) located on the heavy chain of non-primate mammalian antibodies are a possible cause for hypersensitivity reactions to snake antivenom. Serum samples from 55 patients with snakebite envenoming were obtained before administration of snake antivenom and tested for serum IgE (sIgE) against α-gal and total IgE. Read More

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http://dx.doi.org/10.1016/j.toxcx.2020.100054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393571PMC
September 2020

Cost of Manufacturing for Recombinant Snakebite Antivenoms.

Front Bioeng Biotechnol 2020 10;8:703. Epub 2020 Jul 10.

Department of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark.

Snakebite envenoming is a neglected tropical disease that affects millions of people across the globe. It has been suggested that recombinant antivenoms based on mixtures of human monoclonal antibodies, which target key toxins of medically important snake venom, could present a promising avenue toward the reduction of morbidity and mortality of envenomated patients. However, since snakebite envenoming is a disease of poverty, it is pivotal that next-generation therapies are affordable to those most in need; this warrants analysis of the cost dynamics of recombinant antivenom manufacture. Read More

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http://dx.doi.org/10.3389/fbioe.2020.00703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381290PMC

Comparison of F(ab') and Fab antivenoms in rattlesnake envenomation: First year's post-marketing experience with F(ab') in New Mexico.

Toxicon 2020 Aug 5;186:42-45. Epub 2020 Aug 5.

University of New Mexico Health Sciences Center, Department of Emergency Medicine, USA; New Mexico Poison Center, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.

Two antivenoms are available for rattlesnake envenomations in the U.S., Fab (CroFab®, BTG, UK), and F(ab') (Anavip®, Bioclon, Mexico) antivenom (AV) with F(ab')AV released in October 2018. Read More

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http://dx.doi.org/10.1016/j.toxicon.2020.08.002DOI Listing

Report of a severe envenomation.

Clin Toxicol (Phila) 2020 Aug 7:1-4. Epub 2020 Aug 7.

CRT, Institut Pasteur, Paris, France.

Background: Heloderma bites are rare and generally mild, but a few cases can be life threatening.

Case Report: We report a case of envenomation in a healthy 39-year-old herpetologist. The patient rapidly developed tongue and lip swelling associated with stridor. Read More

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http://dx.doi.org/10.1080/15563650.2020.1804574DOI Listing

Viperidae snakebites in Ecuador: A review of epidemiological and ecological aspects.

Toxicon X 2020 Sep 8;7:100051. Epub 2020 Jul 8.

College of Biochemistry and Pharmacy, Faculty of Chemical Sciences, University of Cuenca, Cuenca, Azuay, Ecuador.

Snakebite envenoming is a neglected disease of public health concern. Most snakebite accidents occur in developing countries. In Ecuador, 17 viper species are responsible for 99% of official accidents, and ten species are in critical conservation states. Read More

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http://dx.doi.org/10.1016/j.toxcx.2020.100051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393321PMC
September 2020

Streamlined downstream process for efficient and sustainable (Fab') antivenom preparation.

J Venom Anim Toxins Incl Trop Dis 2020 27;26:e20200025. Epub 2020 Jul 27.

Center for Research and Knowledge Transfer in Biotechnology, University of Zagreb, Zagreb, Croatia.

Background: Antivenoms are the only validated treatment against snakebite envenoming. Numerous drawbacks pertaining to their availability, safety and efficacy are becoming increasingly evident due to low sustainability of current productions. Technological innovation of procedures generating therapeutics of higher purity and better physicochemical characteristics at acceptable cost is necessary. Read More

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http://dx.doi.org/10.1590/1678-9199-jvatitd-2020-0025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384442PMC

SnakeMap: four years of experience with a national small animal snake envenomation registry.

Aust Vet J 2020 Aug 2. Epub 2020 Aug 2.

School of Veterinary Sciences, Massey University, Palmerston North, 4442, New Zealand.

SnakeMap is a national cloud-based, veterinary snakebite registry. It was designed to prospectively collect data of the clinical circumstances and temporospatial information on cases of snake envenomation in dogs and cats. We herein introduce the project and summarise the data from the first 4 years of SnakeMap. Read More

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http://dx.doi.org/10.1111/avj.12993DOI Listing

Cytotoxic and anticancer properties of the Malaysian mangrove pit viper () venom and its disintegrin (purpureomaculin).

J Venom Anim Toxins Incl Trop Dis 2020 17;26:e20200013. Epub 2020 Jul 17.

Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Background: The Asiatic pit vipers from the complex are medically important venomous snakes. These pit vipers are often associated with snakebite that leads to fatal coagulopathy and tissue necrosis. The cytotoxic venoms of spp. Read More

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http://dx.doi.org/10.1590/1678-9199-JVATITD-2020-0013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375409PMC

Epidemiology of snakebites in El Salvador (2014-2019).

Toxicon 2020 Jul 30;186:26-28. Epub 2020 Jul 30.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica.

This study describes the basic epidemiological features of snakebites in El Salvador for the period 2014-2019 on the basis of data provided by the national system of information on morbidity and mortality (Sistema de Morbi-Mortalidad via Web, SIMMOW) of the Ministry of Health of El Salvador. The total number of cases per year ranged from 161 (2017) to 215 (2016). Incidences ranged from 2. Read More

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http://dx.doi.org/10.1016/j.toxicon.2020.07.027DOI Listing

Renal Complications in Children with Hematotoxic Snakebite: More Information Needed: Authors' Reply.

Authors:
Kamirul Islam

Indian Pediatr 2020 Jul;57(7):687-688

Department of Pediatrics, Burdwan Medical College, Burdwan, West Bengal, India.

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Renal Complications in Children with Hematotoxic Snakebite: More Information Needed.

Indian Pediatr 2020 Jul;57(7):686-687

Department of Pediatrics, AIIMS, Bhubaneswar, Odisha, India.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387258PMC

Thrombotic microangiopathy due to Bothrops erythromelas: a case report in Northeast Brazil.

Rev Inst Med Trop Sao Paulo 2020 24;62:e53. Epub 2020 Jul 24.

Departamento de Medicina Interna, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil.

Bothrops erythromelas are serpents that belong to the Viperidae family, which are the main species responsible for human snakebites in Ceara State, Northeast Brazil. Thrombotic microangiopathy (TMA) is an uncommon group of disorders characterized by microangiopathic hemolytic anemia (MAHA), thrombocytopenia and acute kidney injury (AKI), and occurrence after snakebites have been rarely reported. In this report, we described the case of a 57 year-old-man without comorbidities who was bitten by a Bothrops erythromelas on his right ankle. Read More

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http://dx.doi.org/10.1590/s1678-9946202062053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384591PMC

Case of neurotoxic snakebite in a soldier.

Authors:
Eva Howard

BMJ Mil Health 2020 Aug 29;166(4):283. Epub 2020 Jan 29.

16 Medical Regiment, Colchester, UK

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http://dx.doi.org/10.1136/jramc-2019-001331DOI Listing

Cobra snakebite mimicking brain death treated with a novel combination of polyvalent snake antivenom and anticholinesterase: Case report.

Am J Emerg Med 2020 Jul 6. Epub 2020 Jul 6.

Department of Emergency Medicine, Armed Forces Hospital Southern Region, Khamis Mushait, Saudi Arabia.

In toxicology literature, snake bites were the second toxicology-relevant cause mimicking brain death. A 57-year-old woman with history of cobra snake bite. On examination, the brain stem reflexes were absent with Glasgow coma score of 3. Read More

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http://dx.doi.org/10.1016/j.ajem.2020.05.111DOI Listing

Sensitivity and specificity of 20-minute whole blood clotting test, prothrombin time, activated partial thromboplastin time tests in diagnosis of defibrination following Malayan pit viper envenoming.

Toxicon 2020 Jul 23. Epub 2020 Jul 23.

Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand.

Malayan pit vipers (Calloselasma rhodostoma) are major health hazard in Southern Thailand causing systemic bleeding by defibrination and thrombocytopenia. Twenty minute whole blood clotting test (20WBCT) is a useful and informative bedside test recommended by WHO for diagnosis of significant coagulopathy following snakebite envenoming since it to some extent predicts the need for anti-venom therapy. Prothrombin time (PT), international normalized ratio (INR) and activated partial thromboplastin time (APTT) are standard clotting assays that are widely used for diagnosis of coagulopathy. Read More

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http://dx.doi.org/10.1016/j.toxicon.2020.07.020DOI Listing

Snake three-finger α-neurotoxins and nicotinic acetylcholine receptors: molecules, mechanisms and medicine.

Biochem Pharmacol 2020 Jul 23:114168. Epub 2020 Jul 23.

School of Medical Science, Griffith Health Group, Griffith University, Gold Coast, Queensland, Australia. Electronic address:

Snake venom three-finger α-neurotoxins (α-3FNTx) act on postsynaptic nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction (NMJ) to produce skeletal muscle paralysis. The discovery of the archetypal α-bungarotoxin (α-BgTx), almost six decades ago, exponentially expanded our knowledge of membrane receptors and ion channels. This included the localisation, isolation and characterization of the first receptor (nAChR); and by extension, the pathophysiology and pharmacology of neuromuscular transmission and associated pathologies such as myasthenia gravis, as well as our understanding of the role of α-3FNTxs in snakebite envenomation leading to novel concepts of targeted treatment. Read More

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http://dx.doi.org/10.1016/j.bcp.2020.114168DOI Listing

Clinical assessment and pathophysiology of venom-related acute kidney injury: a scoping review.

J Venom Anim Toxins Incl Trop Dis 2020 10;26:e20190076. Epub 2020 Jul 10.

Graduate Program in Medical Sciences, Federal University of Ceará (UFC), Fortaleza, Ceará, Brazil.

are one of the most common medically important snakes found in Latin America. Its venom is predominantly hemotoxic and proteolytic, which means that local lesion (edema and redness) and hemorrhagic symptoms are recurrent in envenoming by this snake. Although hemorrhage is usually the major cause of death, snakebite-related acute kidney injury is another potentially fatal clinical complication that may lead to chronic kidney disease. Read More

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http://dx.doi.org/10.1590/1678-9199-JVATITD-2019-0076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359628PMC

Bothrops erythromelas venom and its action on isolated murine macrophages.

Toxicon 2020 Jul 20. Epub 2020 Jul 20.

Laboratório de Imunologia Celular Aplicada à Saúde, FIOCRUZ Rondônia, Porto Velho, RO, Brazil; Departamento de Medicina, Universidade Federal de Rondônia, UNIR, Porto Velho, RO, Brazil. Electronic address:

Snakebite is a universally neglected public health problem. It victimizes approximately 2.5 million people annually and kills around 125 thousand. Read More

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http://dx.doi.org/10.1016/j.toxicon.2020.07.017DOI Listing

Letter to the Editor: Acute-phase response fever in Viperidae as a potential and additional clinical sign.

Toxicon 2020 Sep 16;184:229-230. Epub 2020 Jul 16.

Via Bobbio, 20144, Milano, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.toxicon.2020.07.008DOI Listing
September 2020

An observational study on acute poisoning in a tertiary care hospital in West Bengal, India.

Perspect Clin Res 2020 Apr-Jun;11(2):75-80. Epub 2020 May 6.

Department of General Medicine, IPGMER, Kolkata, West Bengal, India.

Aim: Poisoning is a preventable cause of morbidity and mortality in India. We undertook a prospective observational study to estimate the incidence, nature, severity and treatment outcome trends of acute poisoning in a tertiary care hospital in eastern India.

Methods: All patients, admitted during the study period with acute poisoning, drug overdose and envenomation, were enrolled. Read More

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http://dx.doi.org/10.4103/picr.PICR_181_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342341PMC

Editorial: Novel Immunotherapies Against Envenomings by Snakes and Other Venomous Animals.

Front Immunol 2020 22;11:1004. Epub 2020 May 22.

Departamento de Bioquímica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

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http://dx.doi.org/10.3389/fimmu.2020.01004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326127PMC

[Incidence of venomous snakebite accidents by snake species in Brazilian biomes].

Cien Saude Colet 2020 Jul;25(7):2837-2846

Universidade do Estado de Mato Grosso. Av. Tancredo Neves 1095, Cavalhada III. 78217-900 Cárceres MT Brasil.

The supply of antidotes for the treatment of venomous snakebite accidents, as well as the training of the care team, should be structured according to the frequency and risks by geographical areas. The scope of this article is to analyze the trend of the incidence of snakebite accidents in Brazilian biomes between 2003 and 2012. It involved the ecological study by means of Prais-Winsten regression of the incidence of snakebites by the Bothrops, Crotalus, Lachesis and Micrurus species for the Brazilian biomes in the period from 2003 to 2012. Read More

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http://dx.doi.org/10.1590/1413-81232020257.31462018DOI Listing

Snakebites in Suriname: Evaluation of the Protocolled Administration of Anti-Snake Venom in a Tertiary Care Setting.

Am J Trop Med Hyg 2020 Jul 13. Epub 2020 Jul 13.

Faculty of Medical Sciences, Anton de Kom University of Suriname, Paramaribo, Suriname.

Venomous snakebites regularly occur in Suriname, a middle-income country located on the north coast of South America. Officially reported data on incidence and mortality are lacking. The aim of this retrospective study was to assess whether the use of our national snakebite protocol with selective administration of anti-snake venom (ASV) in patients with signs of snakebite envenoming improved clinical outcome as measured by mortality and length of stay (LOS) in the hospital. Read More

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http://dx.doi.org/10.4269/ajtmh.20-0144DOI Listing

Comparison of two Anti Snake Venom protocols in hemotoxic snake bite: A randomized trial.

J Forensic Leg Med 2020 Jul 9;73:101996. Epub 2020 Jun 9.

Sri Devaraj Urs Medical College (SDUMC), Sri Devaraj Urs Academy of Higher Education and Research (SDUAHER), Kolar, Karnataka, India.

The dose of Anti Snake Venom (ASV) in hemotoxic snake bite depends on the amount of venom injected and species of snake. All trials in South East Asia have studied different doses of ASV, wherein the ASV in high dose group itself was lower than the dose that is recommended in Indian National protocol. These studies favored low dose protocol, as there was no difference in mortality and morbidity between the groups. Read More

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http://dx.doi.org/10.1016/j.jflm.2020.101996DOI Listing

A pan-specific antiserum produced by a novel immunization strategy shows a high spectrum of neutralization against neurotoxic snake venoms.

Sci Rep 2020 Jul 9;10(1):11261. Epub 2020 Jul 9.

Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia.

Snakebite envenomation is a neglected tropical disease of high mortality and morbidity largely due to insufficient supply of effective and affordable antivenoms. Snake antivenoms are mostly effective against the venoms used in their production. It is thus crucial that effective and affordable antivenom(s) with wide para-specificity, capable of neutralizing the venoms of a large number of snakes, be produced. Read More

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http://dx.doi.org/10.1038/s41598-020-66657-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347863PMC
July 2020
5.078 Impact Factor

The 'Snake song': a pilot study of musical intervention in Eswatini.

Rural Remote Health 2020 Jul 6;20(3):5494. Epub 2020 Jul 6.

Center for Exploration and Travel Health, California Academy of Sciences, San Francisco, CA, USA

Introduction: In Eswatini in Southern Africa, rural populations experience unnecessary snakebite-inflicted injuries and deaths. Children are at the highest risk because of their small size and curious nature. This qualitative study explores the current knowledge and attitudes about snakebite, and the perceptions of a musical intervention, titled Iculo ngenyoka ('Snake song' in Zulu), as an educational tool aimed to raise awareness about snakes in the Lubombo region, Eswatini. Read More

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http://dx.doi.org/10.22605/RRH5494DOI Listing

Bedside perspective to antivenom policy: Practical considerations for selecting antivenoms based on regional challenges.

Toxicon 2020 Apr;177 Suppl 1:S4-S5

Asclepius Snakebite Foundation, Seattle, WA 98107, USA; Whitman College, Department of Biology, Walla Walla, WA 99362, USA; UCSF, Fresno Department of Emergency Medicine, Fresno, CA 93701, USA; Rocky Mountain Poison and Drug Center, Denver, CO 80204, USA; University of Florida College of Medicine, Gainesville, FL 32608, USA; CRT, Institut Pasteur, Paris, 75015, France; MERIT, IRD, Université Paris 5, Sorbonne Paris Cité, Paris, 75006, France.

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http://dx.doi.org/10.1016/j.toxicon.2019.10.022DOI Listing

Cross-species and geographic potential of B-cell epitope strings identified for generation of an Africa-specific snake venom-induced necrosis therapeutic.

Toxicon 2020 Apr;177 Suppl 1:S34-S35

Center for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, UK.

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http://dx.doi.org/10.1016/j.toxicon.2019.12.049DOI Listing

Snake bites: An overview on venom's toxins and antienom IgG related to neurotoxins envenomation.

Toxicon 2020 Apr;177 Suppl 1:S29

Department of Biochemistry, Bayero University, Kano, Nigeria; Petroleum Technology Development Fund, Nigeria.

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http://dx.doi.org/10.1016/j.toxicon.2019.12.028DOI Listing

Toward improved antivenom management of snakebite envenomation in Southeast Asia: The Indonesian perspective.

Toxicon 2020 Apr;177 Suppl 1:S29

Department of Molecular Medicinie, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia; Department of Pharmacology, Faculty of Medicne, Unviersity of Malaya, 50603, Kuala Lumpur, Malaysia.

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http://dx.doi.org/10.1016/j.toxicon.2019.12.029DOI Listing

Developing towards anti-venom drugs by endogenous inhibitor against the metalloproteinase induced hemorrhage; Rational design of drug and therapeutic potential for snakebite.

Toxicon 2020 Apr;177 Suppl 1:S27

Department of Chemistry, Faculty of Science, Fukuoka University, 19-1, 8-chome Nanakuma, Jonan-ku, Fukuoka city, 8140180, Japan; Department of Biological Sciences, Faculty of Science, National University of Singapore, 117543, Singapore; Department of Chemistry, Faculty of Science, Fukuoka University, 19-1, 8-chome Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan.

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http://dx.doi.org/10.1016/j.toxicon.2019.12.023DOI Listing

Effect of vanillin, syringaldehyde, and parahydroxybenzaldehyde extracts on plasma recalcification time of Naja nigricollis venom treated plasma.

Toxicon 2020 Apr;177 Suppl 1:S25-S26

Nigerian Snakebite Research and Intervention Centre (N-SRIC), Bayero University, Kano, Nigeria; Biochemistry Department, Ahmadu Bello University, Zaria, Nigeria.

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http://dx.doi.org/10.1016/j.toxicon.2019.12.017DOI Listing

Repurposing DMPS, a metal chelator, as a rapid field intervention for treating hemotoxic snakebite.

Toxicon 2020 Apr;177 Suppl 1:S21

Centre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Liverpool, UK; AIMMS Division of BioMolecular Analysis, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Laboratorio de Venómica Estructural y Funcional, Instituto de Biomedicina de Valencia, CSIC, Valencia, 46010, Spain.

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http://dx.doi.org/10.1016/j.toxicon.2019.10.248DOI Listing

Novel alternatives for improving the therapy of snakebite envenomings.

Toxicon 2020 Apr;177 Suppl 1:S20-S21

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José Costa Rica, USA.

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http://dx.doi.org/10.1016/j.toxicon.2019.10.246DOI Listing

Severe snakebite envenomations and management.

Authors:
Ceila Málaque

Toxicon 2020 Apr;177 Suppl 1:S18

Butantan Institute, Brazil.

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http://dx.doi.org/10.1016/j.toxicon.2019.10.078DOI Listing

The effect of snake length on the extent of envenoming in Russell's Viper (Daboia siamensis) snake bite cases in Myanmar.

Toxicon 2020 Apr;177 Suppl 1:S15-S16

University of Adelaide, Adelaide, Australia; Women's and Children's Hospital, Adelaide, Australia; University of Oxford, Oxford, UK; Royal Adelaide Hospital, Adelaide, Australia; Myanmar Snakebite Project, Nay Pyi Taw, Myanmar; Yangon Specialist Hospital, Yangon, Myanmar.

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http://dx.doi.org/10.1016/j.toxicon.2019.10.068DOI Listing

"Green snake" bites; Characteristics and significance of this subset of snakebites in the Mandalay region of Myanmar.

Toxicon 2020 Apr;177 Suppl 1:S15

University of Adelaide, Adelaide, Australia; Women's & Children's Hospital, Adelaide, Australia; Myanmar Snakebite Project, Myanmar; Burma Pharmaceutical Industries, Ministry of Industry, Myanmar; Yangon Specialist Hospital, Ministry of Health & Sports, Myanmar; Royal Adelaide Hospital, Adelaide, Australia; University of Oxford, UK.

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http://dx.doi.org/10.1016/j.toxicon.2019.10.067DOI Listing

Clinico-epidemiologic determinants of Limb-loss following snakebite in Nigeria.

Toxicon 2020 Apr;177 Suppl 1:S14

Infectious Disease and Tropical Medicine Unit, Department of Medicine, Bayero University Kano, Nigeria; Kaltingo General Hospital, Gombe State, Nigeria; Kaltungo General Hospital, Gombe State, Nigeria; Bayero University Kano, Nigeria; Liverpool School for Tropical Medicine, United Kingdom.

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http://dx.doi.org/10.1016/j.toxicon.2019.10.063DOI Listing

Bringing snakebite treatment to the point of injury: The asclepius snakebite foundation model for field treatment.

Toxicon 2020 Apr;177 Suppl 1:S14

Asclepius Snakebite Foundation, Seattle, WA, 98107, USA; Whitman College, Department of Biology, Walla Walla, WA, 99362, USA; University of Florida College of Medicine, Gainesville, FL, 32608, USA; UCSF-Fresno Department of Emergency Medicine, Fresno, CA, 93701, USA; Rocky Mountain Poison and Drug Center, Denver, Colorado, 80204, USA.

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http://dx.doi.org/10.1016/j.toxicon.2019.10.064DOI Listing

Burden of snakebite and antivenom supply challenges in Africa.

Toxicon 2020 Apr;177 Suppl 1:S1

Bayero University, Nigeria.

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http://dx.doi.org/10.1016/j.toxicon.2019.10.008DOI Listing

A framework for shifting the paradigm and developing coalitions to address neglected public health problems: Lessons from the Myanmar Snakebite Project.

Toxicon 2020 Apr;177 Suppl 1:S1

School of Public Health, University of Adelaide, Australia; University of Adelaide, Australia; Women's and Children Hospital, Adelaide, South Australia, Australia; University of Medicine 1, Myanmar; Myanmar Pharmaceutical Factory, Ministry of Industry, Myanmar; Royal Adelaide Hospital, Adelaide, South Australia, Australia; Nuffield Department of Clinical Medicine, UK; Myanmar Snakebite Project, Myanmar; School of Public Health, The University of Sydney, Australia; Seqirus, Australia.

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http://dx.doi.org/10.1016/j.toxicon.2019.10.009DOI Listing

Trends in snakebite deaths in India from 2000 to 2019 in a nationally representative mortality study.

Elife 2020 07 7;9. Epub 2020 Jul 7.

Centre for Global Health Research, Unity Health Toronto, and Dalla Lana School of Public Health, University of Toronto, Ontario, Canada.

The World Health Organization call to halve global snakebite deaths by 2030 will require substantial progress in India. We analyzed 2833 snakebite deaths from 611,483 verbal autopsies in the nationally representative Indian Million Death Study from 2001 to 2014, and conducted a systematic literature review from 2000 to 2019 covering 87,590 snakebites. We estimate that India had 1. Read More

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http://dx.doi.org/10.7554/eLife.54076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340498PMC

Muscle proteolysis via ubiquitin-proteasome system (UPS) is activated by BthTx-I Lys49 PLA but not by BthTx-II Asp49 PLA and Bothrops jararacussu venom.

Toxicol Appl Pharmacol 2020 Sep 1;402:115119. Epub 2020 Jul 1.

Department of Biochemistry and Tissue Biology, Institute of Biology, State University of Campinas - UNICAMP, Campinas, SP, Brazil. Electronic address:

Bites by viperid snakes belonging to Bothrops genus produce fast and intense local edema, inflammation, bleeding and myonecrosis. In this study, we investigated the role of Myogenic Regulatory Factors (MRFs: MyoD; Myog), negatively regulated by GDF-8 (Myostatin), and ubiquitin-proteasome system pathway (UPS: MuRF-1; Fbx-32) in gastrocnemius muscle regeneration after Bothrops jararacussu snake venom (Bjussu) or its isolated phospholipase A myotoxins, BthTx-I (Lys-49 PLA) and BthTx-II (Asp-49 PLA) injection. Male Swiss mice received a single intra-gastrocnemius injection of crude Bjussu, at a dose/volume of 0. Read More

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http://dx.doi.org/10.1016/j.taap.2020.115119DOI Listing
September 2020