5,198 results match your criteria Snakebite


Snakebite envenoming.

Lancet 2019 Jan;393(10167):131

Bawaskar Hospital and Clinical Research Center, Mahad 402301, India.

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http://dx.doi.org/10.1016/S0140-6736(18)32745-4DOI Listing
January 2019

Snakebite envenoming.

Lancet 2019 Jan;393(10167):129-131

University of Namibia, Windhoek 93Q5+48, Namibia.

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http://dx.doi.org/10.1016/S0140-6736(18)32762-4DOI Listing
January 2019

Clinical and laboratory features distinguishing between and envenomation.

J Venom Anim Toxins Incl Trop Dis 2018 27;24:43. Epub 2018 Dec 27.

5Department of Emergency Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, No. 539, Zhongxiao Road, East District, Chiayi City, 600 Taiwan.

Background: There are 6 species of venomous snakes in Taiwan. Two of them, () and (), can cause significant coagulopathy. However, a significant proportion of patients with snakebites cannot identify the correct snake species after envenomation, which hampers the application of antivenom. Read More

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http://dx.doi.org/10.1186/s40409-018-0179-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307318PMC
December 2018

Morphometric characteristics and seasonal proximity to water of the Cypriot blunt-nosed viper (Linnaeus, 1758).

J Venom Anim Toxins Incl Trop Dis 2018 27;24:42. Epub 2018 Dec 27.

2Faculty of Forest Sciences and Forest Ecology, Department of Ecoinformatics, Biometrics and Forest Growth, University of Göttingen, Büsgenweg 4, 37077 Göttingen, Germany.

Background: The blunt-nosed viper (Linnaeus, 1758) is a medically important snake species in the Middle East. Its nominate subspecies is confined to Cyprus, where it is the only dangerously venomous snake species and heavily pursued. Despite the viper's large size, data on its body mass and sex-specific morphological differences are scarce. Read More

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http://dx.doi.org/10.1186/s40409-018-0175-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307313PMC
December 2018

Next-generation sequencing analysis reveals high bacterial diversity in wild venomous and non-venomous snakes from India.

J Venom Anim Toxins Incl Trop Dis 2018 22;24:41. Epub 2018 Dec 22.

Department of Forests and Wildlife, Sulthan Batheri, Wayanad District, Kerala 673592 India.

Background: The oral cavities of snakes are replete with various types of bacterial flora. Culture-dependent studies suggest that some of the bacterial species are responsible for secondary bacterial infection associated with snakebite. A complete profile of the ophidian oral bacterial community has been unreported until now. Read More

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http://dx.doi.org/10.1186/s40409-018-0181-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303853PMC
December 2018

Snakebite burden in Sub-Saharan Africa: estimates from 41 countries.

Toxicon 2018 Dec 27;159:1-4. Epub 2018 Dec 27.

Infectious & Tropical Diseases Unit, Aminu Kano Teaching Hospital, Bayero University, Kano, Nigeria. Electronic address:

There is no reliable estimate of burden of snakebite-envenoming (SBE) in Sub-Saharan Africa (SSA). We derived from a meta-analysis the burden of SBE related deaths, amputations and Post-Traumatic Stress Disorder (PTSD) in 41 countries in SSA. The annual burden was estimated at 1. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00410101183118
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http://dx.doi.org/10.1016/j.toxicon.2018.12.002DOI Listing
December 2018
4 Reads

Case Report: Hemothorax in Envenomation by the Viperid Snake .

Am J Trop Med Hyg 2018 Dec 26. Epub 2018 Dec 26.

Universidad Tecnológica Centroamericana, Tegucigalpa, Honduras.

, a highly venomous pit viper distributed from Colombia and northwestern Peru in South America to southern Mexico, is responsible for most snake bites in Central America, affecting especially young agricultural workers. A 17-year-old male from a rural area in northern Honduras was admitted at San Francisco Hospital after a bite that had occurred 3 days earlier. The puncture wounds were located on the first toe of the right foot. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0826DOI Listing
December 2018

Thrombocytopenic purpura following envenomation by the nose-horned viper (Vipera ammodytes ammodytes): Two case reports.

Medicine (Baltimore) 2018 Dec;97(52):e13737

Department of Molecular and Biomedical Sciences, Jožef Stefan Institute, Ljubljana, Slovenia.

Rationale: Two clinical cases are reported of envenomation by the nose-horned viper (Vipera ammodytes ammodytes) venom of a 9-year-old boy and of an 84-year-old woman.

Patient Concerns: Both patients had been bitten on their extremities by such a snake in August near Split, a town in southern Croatia.

Diagnoses: Clinical manifestation of envenomation was severe in the case of the boy, being characterized by a severe coagulopathy. Read More

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http://dx.doi.org/10.1097/MD.0000000000013737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314653PMC
December 2018

Is coagulopathy a common consequence of a Vipera berus bite? A retrospective single centre study.

Ann Agric Environ Med 2018 Dec 16;25(4):630-634. Epub 2017 Oct 16.

First Department of General, Oncological & Gastroenterological Surgery Jagiellonian University Medical College, Cracow, Poland.

Introduction: The Vipera berus (common viper) is the only species of venomous snake found in Poland. The aim of this study was to determine to what extent coagulopathy has occurred as a post-bite complication.

Material And Methods: The medical records of 138 adult patients in the Sucha Beskidzka hospital with the diagnosis of snake bite between 2001-2014 were retrospectively analyzed. Read More

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http://dx.doi.org/10.26444/aaem/75941DOI Listing
December 2018

Global Availability of Antivenoms: The Relevance of Public Manufacturing Laboratories.

Toxins (Basel) 2018 Dec 24;11(1). Epub 2018 Dec 24.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José 11501-2060, Costa Rica.

Snakebite envenoming is a serious global public health problem, and international initiatives, under the coordination of the World Health Organization and its regional offices, are being developed to reduce the impact of this neglected tropical disease. The global availability of safe and effective antivenoms is one of the key aspects in this global strategy. This review discusses the role of public antivenom manufacturing laboratories for ensuring the supply of antivenoms. Read More

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http://dx.doi.org/10.3390/toxins11010005DOI Listing
December 2018

Rattlesnakes bites in the Brazilian Amazon: Clinical epidemiology, spatial distribution and ecological determinants.

Acta Trop 2018 Dec 21;191:69-76. Epub 2018 Dec 21.

Escola Superior de Ciências da Saúde, Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil; Instituto de Pesquisa Clínica Carlos Borborema, Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil. Electronic address:

Crotalus bites are considered a public health problem especially in Latin America. This study was performed to describe the epidemiology, spatial distribution and environmental determinants of Crotalus durissus bites in the Brazilian Amazon. Crotalus durissus envenomings official database included cases reported from 2010 to 2015. Read More

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http://dx.doi.org/10.1016/j.actatropica.2018.12.030DOI Listing
December 2018

Impact of Venom on the Production of Methaemoglobin.

Toxins (Basel) 2018 Dec 15;10(12). Epub 2018 Dec 15.

School of Pharmacy, University of Reading, Reading RG6 6UB, UK.

Snakebite envenomation is an affliction currently estimated to be killing upwards of 100,000 people annually. Snakebite is associated with a diverse pathophysiology due to the magnitude of variation in venom composition that is observed worldwide. The haemolytic (i. Read More

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http://www.mdpi.com/2072-6651/10/12/539
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http://dx.doi.org/10.3390/toxins10120539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316634PMC
December 2018
1 Read

Proteomic analysis and antivenomics study of Western India Naja naja venom: Correlation between venom composition and clinical manifestations of cobra bite in this region.

Expert Rev Proteomics 2018 Dec 17. Epub 2018 Dec 17.

a Microbial Biotechnology and Protein Research Laboratory, Department of Molecular Biology and Biotechnology , Tezpur University , Tezpur 784028 , Assam , India.

Background: Snakebite is a severe problem in the tropical countries including Indian subcontinent. Premier cases of cobra bites are being reported from western India (WI).

Research Design And Methods: The proteome of WI N. Read More

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http://dx.doi.org/10.1080/14789450.2019.1559735DOI Listing
December 2018
1 Read

Biosynthetic Oligoclonal Antivenom (BOA) for Snakebite and Next-Generation Treatments for Snakebite Victims.

Toxins (Basel) 2018 Dec 13;10(12). Epub 2018 Dec 13.

Department of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark.

Snakebite envenoming is a neglected tropical disease that each year claims the lives of 80,000⁻140,000 victims worldwide. The only effective treatment against envenoming involves intravenous administration of antivenoms that comprise antibodies that have been isolated from the plasma of immunized animals, typically horses. The drawbacks of such conventional horse-derived antivenoms include their propensity for causing allergenic adverse reactions due to their heterologous and foreign nature, an inability to effectively neutralize toxins in distal tissue, a low content of toxin-neutralizing antibodies, and a complex manufacturing process that is dependent on husbandry and procurement of snake venoms. Read More

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http://www.mdpi.com/2072-6651/10/12/534
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http://dx.doi.org/10.3390/toxins10120534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315346PMC
December 2018
3 Reads

Snakebite Mitigation Project of the Madras Crocodile Bank/Centre for Herpetology, India: background and a brief summary of activities.

Authors:
Romulus Whitaker

Trans R Soc Trop Med Hyg 2018 Dec 14. Epub 2018 Dec 14.

Project Manager (India), Global Snakebite Initiative, East Coast Road, Mamallapuram, Chennai, India.

Snakebite is a serious problem in rural India where several highly venomous species are commonly found in and around agricultural areas where prey such as rodents and amphibians are abundant. Four snake species, referred to as the Big Four, are responsible for the most serious and fatal bites: spectacled cobra (Naja naja), Russell's viper (Daboia russelii), common krait (Bungarus caeruleus) and saw-scaled viper (Echis carinatus). A polyvalent antivenom is made to treat these bites but public awareness and distribution of this life-saving drug is inadequate. Read More

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http://dx.doi.org/10.1093/trstmh/try130DOI Listing
December 2018

Rational truncation of aptamer for cross-species application to detect krait envenomation.

Sci Rep 2018 Dec 12;8(1):17795. Epub 2018 Dec 12.

Centre for Biodesign and Diagnostics, Translational Health Science and Technology Institute (THSTI), Faridabad, 121001, Haryana, India.

In majority of snakebite cases, the snake responsible for the bite remains unidentified. The traditional snakebite diagnostics method relies upon clinical symptoms and blood coagulation assays that do not provide accurate diagnosis which is important for epidemiological as well as diagnostics point of view. On the other hand, high batch-to-batch variations in antibody performance limit its application for diagnostic assays. Read More

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http://dx.doi.org/10.1038/s41598-018-35985-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290766PMC
December 2018
5.078 Impact Factor

Evaluation of vasoactivity after haemotoxic snake venom administration.

Toxicon 2019 Feb 4;158:69-76. Epub 2018 Dec 4.

Department of Anatomy, Histology and Physiology, University of Veterinary Medicine and Pharmacy, Komenského 73, 041 81, Košice, Slovakia. Electronic address:

The chick chorioallantoic membrane (CAM) is a widely used model in medical research and fulfils the requirements laid out in the 3 R's. The CAM, contains a dense network of blood vessels, essential for embryo development but also makes the chick embryo an invaluable resource for the study of angiogenesis and the haemotoxicity of substances. Non-neurotoxic snake venom is responsible worldwide for numerous deaths but also has been found to have a vast range of medicinal benefit. Read More

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http://dx.doi.org/10.1016/j.toxicon.2018.11.430DOI Listing
February 2019

Coagulotoxic Cobras: Clinical Implications of Strong Anticoagulant Actions of African Spitting Naja Venoms That Are Not Neutralised by Antivenom but Are by LY315920 (Varespladib).

Toxins (Basel) 2018 Dec 4;10(12). Epub 2018 Dec 4.

Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia.

Snakebite is a global tropical disease that has long had huge implications for human health and well-being. Despite its long-standing medical importance, it has been the most neglected of tropical diseases. Reflective of this is that many aspects of the pathology have been underinvestigated. Read More

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http://dx.doi.org/10.3390/toxins10120516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316626PMC
December 2018
1 Read

Development of sandwich ELISA and lateral flow strip assays for diagnosing clinically significant snakebite in Taiwan.

PLoS Negl Trop Dis 2018 Dec 3;12(12):e0007014. Epub 2018 Dec 3.

Department of Emergency Medicine, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan.

Taiwan is an island located in the south Pacific, a subtropical region that is home to 61 species of snakes. Of these snakes, four species-Trimeresurus stejnegeri, Protobothrops mucrosquamatus, Bungarus multicinctus and Naja atra-account for more than 90% of clinical envenomation cases. Currently, there are two types of bivalent antivenom: hemorrhagic antivenom against the venom of T. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292642PMC
December 2018

Plant DNases are potent therapeutic agents against Echis carinatus venom-induced tissue necrosis in mice.

J Cell Biochem 2018 Dec 2. Epub 2018 Dec 2.

Department of Studies in Biochemistry, University of Mysore, Manasagangothri, Mysuru, India.

Echis carinatus envenomation leads to severe tissue necrosis at the bitten site by releasing DNA from immune cells that blocks the blood flow. An earlier report has shown that exogenous DNase 1 offers protection against such severe local tissue necrosis. Tricosanthus tricuspidata is a medicinal plant and the paste prepared from its leaves has been used extensively for the treatment of snakebite-induced tissue necrosis. Read More

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http://dx.doi.org/10.1002/jcb.28115DOI Listing
December 2018
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Mud in the blood: Novel potent anticoagulant coagulotoxicity in the venoms of the Australian elapid snake genus Denisonia (mud adders) and relative antivenom efficacy.

Toxicol Lett 2018 Nov 28;302:1-6. Epub 2018 Nov 28.

FaunaVet Wildlife Consultancy, Glass House Mountains, QLD, 4518, Australia. Electronic address:

Due to their potent coagulotoxicity, Australian elapid venoms are unique relative to non-Australian members of the Elapidae snake family. The majority of Australian elapids possess potent procoagulant venom, while only a few species have been identified as possessing anticoagulant venoms. The majority of research to-date has concentrated on large species with range distributions overlapping major city centres, such as brown snakes (Pseudonaja spp. Read More

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http://dx.doi.org/10.1016/j.toxlet.2018.11.015DOI Listing
November 2018
1 Read

Ontogenetic Change in the Venom of Mexican Black-Tailed Rattlesnakes ().

Toxins (Basel) 2018 Dec 1;10(12). Epub 2018 Dec 1.

Facultad de Ciencias Biológicas, Universidad Juárez del Estado de Durango, Av. Universidad s/n. Fracc. Filadelfia, C.P. 35010 Gómez Palacio, Dgo., Mexico.

Ontogenetic changes in venom composition have important ecological implications due the relevance of venom in prey acquisition and defense. Additionally, intraspecific venom variation has direct medical consequences for the treatment of snakebite. However, ontogenetic changes are not well documented in most species. Read More

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http://dx.doi.org/10.3390/toxins10120501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315878PMC
December 2018
1 Read

Adverse Events in the Efficacy of Crotalidae Polyvalent Immune Fab Antivenom vs Placebo in Recovery from Copperhead Snakebite Trial.

South Med J 2018 Dec;111(12):716-720

From the Division of Emergency Medicine, Washington University School of Medicine, St Louis, Missouri, the Division of Emergency Medicine, Duke University, Durham, North Carolina, the Department of Emergency Medicine, East Carolina University Brody School of Medicine, Greenville, North Carolina, the Department of Emergency Medicine, Virginia Commonwealth University, Richmond, the Department of Emergency Medicine, Baylor College of Medicine, Houston, Texas, the Department of Emergency Medicine, University of North Carolina, Chapel Hill, North Carolina, Texas A&M Health Sciences Center, Bryan, Rocky Mountain Poison & Drug Center, Denver, Colorado, the Department of Emergency Medicine, UT Southwestern Medical Center, Dallas, Texas, the Department of Emergency Medicine, Augusta University, Augusta, Georgia, the Department of Emergency Medicine, University of Virginia, Charlottesville, the Department of Surgery, East Carolina University Brody School of Medicine, Greenville, North Carolina, and the Department of Surgery, Marshall University, Huntington, West Virginia.

Objective: To compare the incidence of hypersensitivity reactions following copperhead envenomation treated with Fab antivenom (FabAV) or placebo.

Methods: Patients with copperhead snakebites received treatment and follow-up in a prospective, randomized, double-blind, placebo-controlled trial of FabAV or placebo. The treatment allocation ratio was 2:1 (FabAV:placebo). Read More

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http://dx.doi.org/10.14423/SMJ.0000000000000902DOI Listing
December 2018
3 Reads

Snakebite envenomation in the Brazilian Amazon: a descriptive study.

Trans R Soc Trop Med Hyg 2018 Nov 24. Epub 2018 Nov 24.

Núcleo de Medicina Tropical (Tropical Medicine Centre), Universidade de Brasília (UnB), University Campus Darcy Ribeiro, Asa Norte, Brasília-DF, Brazil.

Snakebite envenomation in the Brazilian Amazon is a recognized public health problem that does not receive the appropriate attention from key stakeholders. The morbidity rate is relevant, but still underestimated. Thus, the present study updates the current state of knowledge on snakebite envenomation in the Brazilian Amazon. Read More

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/trstmh/try121DOI Listing
November 2018
4 Reads

First reported case of thrombocytopenia from a Heterodon nasicus envenomation.

Toxicon 2019 Jan 19;157:12-17. Epub 2018 Nov 19.

Rocky Mountain Poison and Drug Center - Denver Health and Hospital Authority, Denver, CO, USA.

Context: The vast majority of the 2.5 million annual worldwide venomous snakebites are attributed to Viperidae or Elapidae envenomations. Of the nearly 2000 Colubridae species described, only a handful are known to cause medically significant envenomations. Read More

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http://dx.doi.org/10.1016/j.toxicon.2018.11.295DOI Listing
January 2019
1 Read

Fatal Snakebite Envenoming and Agricultural Work in Brazil: A Case-Control Study.

Am J Trop Med Hyg 2019 Jan;100(1):150-154

Faculdade de Medicina da Bahia, Federal University of Bahia, Salvador, Brazil.

We investigated the association between fatal snakebite envenoming and agricultural work in Brazil, considering the effects of relevant covariables. A nested case-control study was performed using 1,119 fatal cases of snakebite envenoming among persons aged ≥ 10 years, notified to the Brazilian official reporting system, from 2004 to 2015. As controls, 4,476 cases were randomly selected from the 115,723 nonfatal cases of snakebite, without missing data, that occurred in the same time period. Read More

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http://www.ajtmh.org/content/journals/10.4269/ajtmh.18-0579
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http://dx.doi.org/10.4269/ajtmh.18-0579DOI Listing
January 2019
3 Reads

Serum Procalcitonin Concentration and Its Relationship with Local Manifestations after Snakebites.

Am J Trop Med Hyg 2019 Jan;100(1):146-149

Departments of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.

The local signs and symptoms following snakebites are similar to those of cellulitis caused by bacterial infections. This leads to empirical treatment with antibiotics, which however is not supported by evidence. Procalcitonin (PCT) is a biomarker with good diagnostic accuracy for bacterial infection. Read More

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http://www.ajtmh.org/content/journals/10.4269/ajtmh.17-0892
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http://dx.doi.org/10.4269/ajtmh.17-0892DOI Listing
January 2019
5 Reads

Delayed LY333013 (Oral) and LY315920 (Intravenous) Reverse Severe Neurotoxicity and Rescue Juvenile Pigs from Lethal Doses of (Eastern Coral Snake) Venom.

Toxins (Basel) 2018 Nov 17;10(11). Epub 2018 Nov 17.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José 11501-2060, Costa Rica.

Objective: There is a clear, unmet need for effective, lightweight, shelf-stable and economical snakebite envenoming therapies that can be given rapidly after the time of a snake's bite and as adjuncts to antivenom therapies in the hospital setting. The sPLA2 inhibitor, LY315920, and its orally bioavailable prodrug, LY333013, demonstrate surprising efficacy and have the characteristics of an antidote with potential for both field and hospital use.

Methods: The efficacy of the active pharmaceutical ingredient (LY315920) and its prodrug (LY333013) to treat experimental, lethal envenoming by (Eastern coral snake) venom was tested using a porcine model. Read More

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http://dx.doi.org/10.3390/toxins10110479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265968PMC
November 2018
6 Reads

Analysis of effectiveness of Iranian snake antivenom on Viper venom induced effects including analysis of immunologic biomarkers in the Echis carinatus sochureki envenomed victims.

Toxicon 2019 Feb 16;158:38-46. Epub 2018 Nov 16.

Medical Toxicology Center, Imam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Snakebite is an important toxicologic emergency with the potential of triggering local and systemic inflammation. Antivenom has remained the mainstay of treatment for snakebite envenomation. In this study we sought to investigate the effectiveness of Iranian antivenom in a series of 44 viper envenomed patients through analysis of changes in clinical severity and the levels of inflammatory markers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00410101183101
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http://dx.doi.org/10.1016/j.toxicon.2018.11.293DOI Listing
February 2019
5 Reads
2.492 Impact Factor

Incidence of snakebites in 3 different geographic regions in Thua Thien Hue province, central Vietnam: Green pit vipers and cobras cause the majority of bites.

Toxicon 2018 Dec 15;156:61-65. Epub 2018 Nov 15.

Institute for Community Health Research, College of Medicine and Pharmacy, Hue University, Hue, Viet Nam.

Background: The annual incidence of snakebites in Vietnam is not known and only few publications about snakebite envenoming and medically relevant snakes can be found in English language literature. The present community-based surveys provide data on incidence of snakebites in three different geographic regions of Thua Thien Hue (TT Hue) province, central Vietnam and snake species responsible for bites in this region.

Methodology/results: The cross-sectional community based surveys were conducted from March to July 2017. Read More

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http://dx.doi.org/10.1016/j.toxicon.2018.11.009DOI Listing
December 2018
2 Reads

An unusual case of gross myoglobinuria in a child following Russell's viper (Daboia russelii) envenomation.

Toxicon 2019 Jan 16;157:77-79. Epub 2018 Nov 16.

Department of Medicine, Faculty of Medicine, University of Peradeniya, 20400, Sri Lanka.

Overt myoglobinuria associated with myotoxicity is a classic feature of sea snake envenomation. Russell's viper bites usually result in coagulopathy, neurotoxicity and nephrotoxicity but rarely myotoxicity has been reported, especially in the Sri Lankan variety (Daboia russelii). All those studies have demonstrated mild degree myotoxicity with microscopic level myoglobinuria. Read More

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http://dx.doi.org/10.1016/j.toxicon.2018.11.299DOI Listing
January 2019
8 Reads

Thrombotic microangiopathy following Bothrops jararaca snakebite: case report.

Clin Toxicol (Phila) 2018 Nov 16:1-6. Epub 2018 Nov 16.

c Department of Pharmacology, School of Medical Sciences , State University of Campinas (UNICAMP) , Campinas , Brazil.

Context: Thrombotic microangiopathy (TMA) is an uncommon and severe complication of snakebites, and is similar, in general, to hemolytic-uremic syndrome (HUS). We describe a case of TMA following envenomation by Bothrops jararaca.

Case Details: A 56-y-old-woman with controlled hypertension was transferred from a primary hospital to our ER ∼7 h after being bitten by B. Read More

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http://dx.doi.org/10.1080/15563650.2018.1514621DOI Listing
November 2018
8 Reads

Acute kidney injury induced by thrombotic microangiopathy in two cases of Bothrops envenomation.

Clin Toxicol (Phila) 2018 Nov 15:1-4. Epub 2018 Nov 15.

c Laboratory of Pathophysiology , Butantan Institute , São Paulo , Brazil.

Context: Bothrops snakes are the most frequent agents of snakebites in South and Central America. Acute kidney injury (AKI) is one of its complications and has multifactorial origin. Thrombotic microangiopathy (TMA)-induced AKI in snakebites is uncommon and is not described in Bothrops envenomation. Read More

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http://dx.doi.org/10.1080/15563650.2018.1510129DOI Listing
November 2018
10 Reads

Utility of Clot Waveform Analysis in Russell's Viper Bite Victims with Hematotoxicity.

J Emerg Trauma Shock 2018 Jul-Sep;11(3):211-216

Department of Emergency Medicine, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, India.

Introduction: In Russell's viper bites, due to the lack of a better alternative, whole blood clotting test (WBCT) remains the standard test even though its reliability and sensitivity has been shown to be low. Activated partial thromboplastin time (aPTT)-based clot waveform analysis (CWA) is an optic absorbance assay that can be used as a global clotting test. In this study, the objective was to assess the changes in CWA and to compare CWA to WBCT and aPTT in patients with Russell's viper envenomation. Read More

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http://dx.doi.org/10.4103/JETS.JETS_43_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182961PMC
November 2018
2 Reads

Innovative Immunization Strategies for Antivenom Development.

Toxins (Basel) 2018 Nov 2;10(11). Epub 2018 Nov 2.

Department of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark.

Snakes, scorpions, and spiders are venomous animals that pose a threat to human health, and severe envenomings from the bites or stings of these animals must be treated with antivenom. Current antivenoms are based on plasma-derived immunoglobulins or immunoglobulin fragments from hyper-immunized animals. Although these medicines have been life-saving for more than 120 years, opportunities to improve envenoming therapy exist. Read More

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http://www.mdpi.com/2072-6651/10/11/452
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http://dx.doi.org/10.3390/toxins10110452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265855PMC
November 2018
8 Reads

Identification of a linear B-cell epitope in the catalytic domain of bothropasin, a metalloproteinase from Bothrops jararaca snake venom.

Mol Immunol 2018 Dec 3;104:20-26. Epub 2018 Nov 3.

Departamento de Bioquímica-Imunologia, ICB, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, CEP: 31270-901 Belo Horizonte, Minas Gerais, Brazil. Electronic address:

Bothropasin is a hemorrhagic snake venom metalloproteinase (SVMP) from Bothrops jararaca venom, the snake responsible for most bites in Southeastern Brazil. SVMPs, such as bothropasin, are involved in the main bothropic envenoming symptoms, which include hemorrhage, inflammation, necrosis and blood coagulation deficiency. B-cell epitope mapping of SVMPs can lead to the identification of peptides capable of inducing neutralizing antibodies without causing toxic effects, therefore improving anti-venom production. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01615890183072
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http://dx.doi.org/10.1016/j.molimm.2018.10.019DOI Listing
December 2018
9 Reads

Prophylactic Antibiotics Are Not Needed Following Rattlesnake Bites.

Am J Med 2018 Nov 4;131(11):1367-1371. Epub 2018 Jul 4.

Division of Infectious Diseases, Department of Medicine. Electronic address:

Background: Antibiotics are sometimes administered to victims of rattlesnake bites in the hope of preventing infections. Experts in the field recommend that prophylactic antibiotics not be used because secondary infections are rare. Current recommendations are based on a small number of studies conducted in the United States. Read More

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http://dx.doi.org/10.1016/j.amjmed.2018.06.006DOI Listing
November 2018
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Severe Systemic Envenomation Following Vipera berus Bite Managed with ViperaTAb Antivenom.

Wilderness Environ Med 2018 Oct 29. Epub 2018 Oct 29.

Pharmacology, Toxicology, and Therapeutics, University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom (Dr Lamb).

Bites by the European adder (Vipera berus) are a rare medical emergency in the UK with 20 to 50% of an estimated 50 to 200 cases per year necessitating treatment with antivenom. We present a case demonstrating both severe systemic and local effects necessitating out of hospital resuscitation, vasopressor support, and prolonged rehabilitation. Hemodynamic stability was restored promptly after administration of ViperaTAb antivenom, the first published case of its use in the UK. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10806032183015
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http://dx.doi.org/10.1016/j.wem.2018.08.002DOI Listing
October 2018
3 Reads

Potential Utilization of a Polysaccharide from the Marine Algae , as an Antivenom for Viperidae Snakebites.

Mar Drugs 2018 Oct 27;16(11). Epub 2018 Oct 27.

Department of Molecular and Cellular Biology, Federal Fluminense University, Niterói, Rio de Janeiro 24020-141, Brazil.

Worldwide, snakebites have serious implications for human health. The administration of antivenom is the official treatment used to reverse the toxic activities of envenomation. However, this therapy is not efficient to treat the local effects, leading to the amputation or deformity of affected limbs. Read More

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http://dx.doi.org/10.3390/md16110412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266287PMC
October 2018
3 Reads

Knowledge, attitude and practices of snakebite management amongst health workers in Cameroon: Need for continuous training and capacity building.

PLoS Negl Trop Dis 2018 10 25;12(10):e0006716. Epub 2018 Oct 25.

Cameroon Society of Epidemiology, Yaounde, Cameroon.

Background: Snakebite has only recently been recognized as a neglected tropical disease by the WHO. Knowledge regarding snakebites and its care is poor both at the population level, and at the health care staff level. The goal of this study was to describe the level of knowledge and clinical practice regarding snakebite among health care staff from Cameroon. Read More

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http://dx.plos.org/10.1371/journal.pntd.0006716
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http://dx.doi.org/10.1371/journal.pntd.0006716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219812PMC
October 2018
7 Reads

Proteomics analysis to compare the venom composition between Naja naja and Naja kaouthia from the same geographical location of eastern India: Correlation with pathophysiology of envenomation and immunological cross-reactivity towards commercial polyantivenom.

Expert Rev Proteomics 2018 Nov 31;15(11):949-961. Epub 2018 Oct 31.

a Microbial Biotechnology and Protein Research Laboratory, Department of Molecular Biology and Biotechnology , Tezpur University , Tezpur , India.

Background: Cobra bite is frequently reported across the Indian subcontinent and is associated with a high rate of death and morbidity. In eastern India (EI) Naja naja and Naja kaouthia are reported to be the two most abundant species of cobra.

Research Design And Methods: The venom proteome composition of N. Read More

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https://www.tandfonline.com/doi/full/10.1080/14789450.2018.1
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http://dx.doi.org/10.1080/14789450.2018.1538799DOI Listing
November 2018
13 Reads

Snake Bite Envenomation in a Tertiary Care Centre.

J Assoc Physicians India 2018 Mar;66(3):50-54

Ex. Professor and Head, Department of Medicine, Lokmanya Tilak Municipal Medical College, Mumbai, Maharashtra.

Background: In India, it is estimated that up to 20,000 people die annually from snake bites. The present study was carried to out to estimate the snake bite related epidemiology, predictors of severity, relationship between type of snake, clinical severity, complications, outcome and usage pattern of polyvalent anti snake venom (ASV) in a tertiary care center.

Methods: All indoor patients admitted in our institute with definitive history of bite by a snake, with or without presence of fang marks, Evidence of cellulitis, acute onset of neurotoxicity or bleeding diathesis were serially recruited in the study. Read More

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March 2018
3 Reads

Inhibition of a Snake Venom Metalloproteinase by the Flavonoid Myricetin.

Molecules 2018 Oct 16;23(10). Epub 2018 Oct 16.

Programa de Ofidismo/Escorpionismo, Facultad de Ciencias Farmacéuticas y Alimentarias, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín 050010, Colombia.

Most of the snakebite envenomations in Central and South America are caused by species belonging to genus. Their venom is composed mainly by zinc-dependent metalloproteinases, responsible of the hemorrhage characteristic of these envenomations. The aim of this study was to determine the inhibitory ability of ten flavonoids on the in-vitro proteolytic activity of venom and on the hemorrhagic, edema-forming and myonecrotic activities of Batx-I, the most abundant metalloproteinase isolated from this venom. Read More

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http://www.mdpi.com/1420-3049/23/10/2662
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http://dx.doi.org/10.3390/molecules23102662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222685PMC
October 2018
7 Reads

Delayed hypopituitarism following Russell's viper envenomation: a case series and literature review.

Pituitary 2018 Oct 13. Epub 2018 Oct 13.

Department of Endocrinology, Vydehi Institute of Medical Sciences and Research Centre, #82, EPIP Area, Whitefield, Bangalore, Karnataka, 560066, India.

Purpose: Hypopituitarism (HP) is an uncommon consequence of Russell's viper envenomation (RVE). Delayed hypopituitarism (DHP) presents months to years after recovering from snake bites (SB). The clinical presentation, manifestations, and outcomes of DHP following RVE have not been systematically studied. Read More

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http://dx.doi.org/10.1007/s11102-018-0915-1DOI Listing
October 2018
2 Reads

Coagulotoxicity of (Lancehead Pit-Vipers) Venoms from Brazil: Differential Biochemistry and Antivenom Efficacy Resulting from Prey-Driven Venom Variation.

Toxins (Basel) 2018 Oct 11;10(10). Epub 2018 Oct 11.

Venom Evolution Lab, School of Biological Sciences, University of Queensland, St. Lucia, QLD 4072, Australia.

Lancehead pit-vipers ( genus) are an extremely diverse and medically important group responsible for the greatest number of snakebite envenomations and deaths in South America. (common lancehead), responsible for majority of snakebites and related deaths within the Brazilian Amazon, is a highly adaptable and widely distributed species, whose venom variability has been related to several factors, including geographical distribution and habitat type. This study examined venoms from four populations (Belterra and Santarém, PA; Pres. Read More

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http://www.mdpi.com/2072-6651/10/10/411
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http://dx.doi.org/10.3390/toxins10100411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215258PMC
October 2018
2 Reads

Russell's Viper Envenomation-Associated Addisonian Crisis.

Wilderness Environ Med 2018 Dec 8;29(4):504-507. Epub 2018 Oct 8.

Department of Internal Medicine, Trichy SRM Medical College Hospital and Research Center, Irungalur, Trichy, India (Prof Thirumalaikolundusubramanian).

Snakebite envenomation is an important public health problem in tropical countries. We report a case of bilateral adrenal hemorrhage in a 28-y-old man with Russell's viper bite that occurred in the Sathyamangalam forest range in the Indian state of Tamil Nadu. In this case, a combination of early bite recognition, hospital-based supportive care, corticosteroid therapy, and timely administration of polyvalent antivenom resulted in a favorable clinical outcome. Read More

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http://dx.doi.org/10.1016/j.wem.2018.06.001DOI Listing
December 2018
4 Reads

Rutin (quercetin-3-rutinoside) modulates the hemostatic disturbances and redox imbalance induced by Bothrops jararaca snake venom in mice.

PLoS Negl Trop Dis 2018 10 11;12(10):e0006774. Epub 2018 Oct 11.

Laboratory of Pathophysiology, Institute Butantan, São Paulo, São Paulo, Brazil.

Snakebites are a major Collective Health problem worldwide. In Brazil, Bothrops jararaca snake venom (BjV) evokes hemostatic disturbances, bleeding manifestations, and redox status imbalance. Specific antivenom therapy, although efficacious to revert most snakebite-induced manifestations, is incapable of treating secondary manifestations, such as oxidative/nitrosative stress. Read More

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http://dx.plos.org/10.1371/journal.pntd.0006774
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http://dx.doi.org/10.1371/journal.pntd.0006774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181271PMC
October 2018
4 Reads

Epidemiology and outcome of acute kidney injury due to venomous animals from a subtropical region of India.

Clin Toxicol (Phila) 2018 Oct 11:1-6. Epub 2018 Oct 11.

c Community Medicine , Indira Gandhi Medical College , Shimla , India.

Aim: To study the epidemiology and outcome of acute kidney injury (AKI) caused by venomous animals.

Methods: A retrospective study of patients admitted at Indira Gandhi Medical College Hospital, Shimla, with AKI due to venomous animals over a period of 15 years (January 2003-December 2017). Medical records were evaluated for patient information on demographic factors, clinical characteristics, complications, and outcome. Read More

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https://www.tandfonline.com/doi/full/10.1080/15563650.2018.1
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http://dx.doi.org/10.1080/15563650.2018.1513526DOI Listing
October 2018
9 Reads

Letter to the editor: "safety of nonsteroidal anti-inflammatory drugs in copperhead snakebite patients" by Pham and Mullins, Clin Toxicol 2018 May 18.

Clin Toxicol (Phila) 2018 Oct 11:1-2. Epub 2018 Oct 11.

c Division of Emergency Medicine, Department of Surgery , Duke University School of Medicine , Raleigh , NC , USA.

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http://dx.doi.org/10.1080/15563650.2018.1502445DOI Listing
October 2018
1 Read