5,254 results match your criteria Snakebite


Thrombin generation test for evaluating hemostatic effects of Brazilian snake venoms.

Toxicon 2019 Mar 14. Epub 2019 Mar 14.

Clinical and Toxicological Department, Faculty of Pharmacy. Federal University of Minas Gerais, Brazil. Electronic address:

Snake venoms as well as their components have been tested worldwide to find new molecules for prophylaxis and treatment of several pathologies or even for diagnostic purposes. It is widely known that snake venoms contain enzymes and non-enzymatic proteins that interfere with hemostasis leading to hemorrhage or even thrombosis. The treatment of snake envenoming and the development of new drugs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxicon.2019.03.012DOI Listing

Rattlesnake venom-induced recurrent coagulopathy in first trimester pregnant women - Two Cases.

Toxicon 2019 Mar 14;163:8-11. Epub 2019 Mar 14.

Department of Medical Toxicology, Banner-University Medical Center Phoenix, University of Arizona College of Medicine, USA.

Delayed or recurrent coagulopathy can occur up to 14 days after North American rattlesnake envenomation in patients that have been treated with Crotalidae Polyvalent Immune Fab (CroFab). There is little data in the literature characterizing the sequelae of North American rattlesnake envenomation in pregnancy and no previously published reports of recurrent coagulopathy in pregnancy. CASE REPORT: We present 2 cases of first trimester pregnant women requiring readmission and retreatment with Crotalidae Polyvalent Immune Fab (CroFab) after developing recurrent/late coagulopathy following North American Rattlesnake Envenomation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxicon.2019.03.006DOI Listing

Snake Eyes: Coral Snake Neurotoxicity Associated With Ocular Absorption of Venom and Successful Treatment With Exotic Antivenom.

J Emerg Med 2019 Mar 14. Epub 2019 Mar 14.

Department of Emergency Medicine, Baylor Scott and White Medical Center - Temple, Texas A&M Health Science Center College of Medicine, Temple, Texas.

Background: Coral snake bites from Micrurus fulvius and Micrurus tener account for < 1% of all snake bites in North America. Coral snake envenomation may cause significant neurotoxicity, including respiratory insufficiency, and its onset may be delayed up to 13 h.

Case Report: We present a unique patient encounter of M. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jemermed.2019.01.019DOI Listing

Severe Viperidae envenomation complicated by a state of shock, acute kidney injury, and gangrene presenting late at the emergency department: a case report.

BMC Emerg Med 2019 Mar 12;19(1):26. Epub 2019 Mar 12.

Department of Emergency medicine, Anesthesiology and critical care, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.

Background: Snake envenomation is an underestimated pathology in sub-Saharan Africa associated with severe emergencies, and even death in case of late presentation. We herein present a case of severe envenomation managed at the surgical emergency department of the Yaoundé Central Hospital.

Case Presentation: We report a case of a 47-year-old female farmer with no relevant past history who sustained a snakebite by an Echis occellatus viper during an agricultural activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12873-019-0239-0DOI Listing
March 2019
1 Read

Characteristics and relative numbers of lethal snake bite cases in medicolegal practice in central Myanmar - A five year study.

J Forensic Leg Med 2019 Apr 5;63:52-55. Epub 2019 Mar 5.

The University of Adelaide Medical School, Frome Road, Adelaide, SA, 5005, Australia; Forensic Science SA, 21 Divett Place, Adelaide, SA, 5000, Australia. Electronic address:

Clinical and pathological case files of lethal snakebites were reviewed from the XXXX, Magway, Myanmar, over a five-year period (January 2013 December 2017). A total of 2069 postmortem examinations were performed which included 84 cases of lethal snake bite (4.1%). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S1752928X183050
Publisher Site
http://dx.doi.org/10.1016/j.jflm.2019.03.005DOI Listing
April 2019
2 Reads

Bites by Tomodon dorsatus (serpentes, dipsadidae): Clinical and epidemiological study of 86 cases.

Toxicon 2019 Mar 7;162:40-45. Epub 2019 Mar 7.

Museu Biológico, Instituto Butantan, São Paulo, SP, Brazil.

A total of 86 proven cases of Tomodon dorsatus bites admitted to Hospital Vital Brazil (HVB) of Butantan Institute, in São Paulo, Brazil, between 1945 and 2018, were retrospectively analyzed. The cases included were those in which the snake was brought to HVB and was correctly identified. Of the 86 cases of snake bites, it was possible to describe the sex of the snake in 52 cases; 31 (59. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxicon.2019.03.005DOI Listing

Acute Kidney Injury Induced by Venom: Insights into the Pathogenic Mechanisms.

Toxins (Basel) 2019 Mar 5;11(3). Epub 2019 Mar 5.

Medical Sciences of Post-Graduate Program, Department of Internal Medicine, Federal University of Ceara, CEP 60416-200 Fortaleza, Ceara, Brazil.

Acute kidney injury (AKI) following snakebite is common in developing countries and genus is the main group of snakes in Latin America. To evaluate the pathogenic mechanisms associated with venom nephrotoxicity, we assessed urinary and blood samples of patients after hospital admission resulting from snakebite in a prospective cohort study in Northeast Brazil. Urinary and blood samples were evaluated during hospital stay in 63 consenting patients, divided into AKI and No-AKI groups according to the KDIGO criteria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/toxins11030148DOI Listing
March 2019
1 Read

The validity, reliability and minimal clinically important difference of the patient specific functional scale in snake envenomation.

PLoS One 2019 5;14(3):e0213077. Epub 2019 Mar 5.

Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, Denver, Colorado, United States of America.

Objective: Valid, reliable, and clinically relevant outcome measures are necessary in clinical studies of snake envenomation. The aim of this study was to evaluate the psychometric (validity and reliability) and clinimetric (minimal clinically important difference [MCID]) properties of the Patient-Specific Functional Scale (PSFS) in snakebite envenomation.

Methods: We performed a secondary analysis of two existing snakebite trials that measured clinical outcomes using the PSFS as well as other quality of life and functional assessments. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213077PLOS
March 2019
5 Reads

The kiss of (cell) death: can venom-induced immune response contribute to dermal necrosis following arthropod envenomations?

Clin Toxicol (Phila) 2019 Feb 26:1-9. Epub 2019 Feb 26.

a Venom Systems and Proteomics Lab, School of Natural Sciences , Ryan Institute, National University of Ireland Galway , Galway , Ireland.

Introduction: Snakes, insects, arachnids and myriapods have been linked to necrosis following envenomation. However, the pathways involved in arthropod venom-induced necrosis remain a highly controversial topic among toxinologists, clinicians and the public. On the one hand, clinicians report on alleged envenomations based on symptoms and the victims' information. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15563650.2019.1578367DOI Listing
February 2019

Expression of an scFv antibody fragment in Nicotiana benthamiana and in vitro assessment of its neutralizing potential against the snake venom metalloproteinase BaP1 from Bothrops asper.

Toxicon 2019 Mar 22;160:38-46. Epub 2019 Feb 22.

Laboratorio de Genética, Instituto de Ciências Biológicas, Universidade Federal de Juiz de Fora, Rua José Lourenço Kelmer, S/n - Martelos, Juiz de Fora, MG, 36036-330, Brazil. Electronic address:

Human accidents with venomous snakes represent an overwhelming public health problem, mainly in rural populations of underdeveloped countries. Their high incidence and the severity of the accidents result in 81,000 to 138,000 deaths per year. The treatment is based on the administration of purified antibodies, produced by hyper immunization of animals to generate immunoglobulins (Igs), and then obtained by fractionating hyper immune plasma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxicon.2019.02.011DOI Listing
March 2019
1 Read

Surgical Considerations for Pediatric Snake Bites in Low- and Middle-Income Countries.

World J Surg 2019 Feb 19. Epub 2019 Feb 19.

Department of Surgery, Pietermaritzburg Metropolitan Complex, University of KwaZulu-Natal, Pietermaritzburg, South Africa.

Background: Snake envenomation is associated with major morbidity especially in low- and middle-income countries and may require fasciotomy. We determined patient factors associated with the need for fasciotomy after venomous snake bites in children located in KwaZulu-Natal, South Africa.

Methods: Single institutional review of historical data (2012-2017) for children (<18 years) sustaining snake envenomation was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00268-019-04953-9DOI Listing
February 2019
2 Reads
2.642 Impact Factor

Role of therapeutic plasma exchange in snake bite associated thrombotic microangiopathy-A case report with review of literature.

J Clin Apher 2019 Feb 19. Epub 2019 Feb 19.

Department of Immunohematology and Blood Transfusion, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Post snake bite renal failure due to thrombotic microangiopathy (TMA) is often overlooked and not considered as a separate entity while managing the patient. This case report highlights the efficacy of Therapeutic Plasma Exchange in managing the post envenomation TMA. Anti-snake venom was administered following severe hematotoxic envenomation, but later on developed acute kidney injury and hence hemodialysis was done for 2 days without much improvement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21691DOI Listing
February 2019
1 Read

Inadequate knowledge about snakebite envenoming symptoms and application of harmful first aid methods in the community in high snakebite incidence areas of Myanmar.

PLoS Negl Trop Dis 2019 02 15;13(2):e0007171. Epub 2019 Feb 15.

Department of Renal Medicine, Royal Adelaide Hospital, Adelaide, Australia.

Introduction: Every year millions of people in developing countries suffer from snakebite, causing a large number of deaths and long term complications. Prevention and appropriate first aid could reduce the incidence and improve the health outcomes for those who suffer bites. However, many communities where snakebite is a major issue suffer from a lack of information about prevention and first aid measures that a family or community member could take to prevent severe envenoming, complications and poor outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0007171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395000PMC
February 2019
2 Reads

Intact protein mass spectrometry reveals intraspecies variations in venom composition of a local population of Vipera kaznakovi in Northeastern Turkey.

J Proteomics 2019 Feb 11;199:31-50. Epub 2019 Feb 11.

Technische Universität Berlin, Institut für Chemie, Strasse des 17. Juni 124, 10623 Berlin, Germany. Electronic address:

We report on the variable venom composition of a population of the Caucasus viper (Vipera kaznakovi) in Northeastern Turkey. We applied a combination of venom gland transcriptomics, de-complexing bottom-up and top-down venomics. In contrast to sole bottom-up venomics approaches and gel or chromatography based venom comparison, our combined approach enables a faster and more detailed comparison of venom proteomes from multiple individuals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jprot.2019.02.004DOI Listing
February 2019
2 Reads

Does This Patient Have a Severe Snake Envenomation?: The Rational Clinical Examination Systematic Review.

JAMA Surg 2019 Feb 13. Epub 2019 Feb 13.

Department of Emergency Medicine and Rocky Mountain Poison and Drug Center, Denver Health, Denver, Colorado.

Importance: Venomous snakebite severity ranges from an asymptomatic dry bite to severe envenomation and death. The clinical evaluation aids in prognosis and is essential to determine the risks and potential benefits of antivenom treatment.

Objectives: To identify historical features, clinical examination findings, basic laboratory testing, and clinical grading scales that will risk-stratify patients with pit viper snake envenomation for severe systemic envenomation, severe tissue injury, and/or severe hematologic venom effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamasurg.2018.5069DOI Listing
February 2019
2 Reads

Retrospective Documentation of a Confirmed White-Lipped Green Pit Viper (Trimeresurus albolabris Gray, 1842) Bite in the South-Central Hills of Nepal.

Wilderness Environ Med 2019 Mar 6;30(1):79-85. Epub 2019 Feb 6.

National Academy of Medical Sciences, Bir Hospital, Kathmandu, Nepal.

This case report documents envenomation by an arboreal white-lipped green pit viper (Trimeresurus albolabris), a species found in South and Southeast Asia that causes the majority of venomous snakebites among Southeast Asian pit vipers. Clinical features vary from asymptomatic to serious coagulopathy that may progress into life-threatening or fatal hemorrhage. The proven life-threatening cases described in published literature, however, are sparse. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wem.2018.11.001DOI Listing
March 2019
2 Reads

Venomics of , the Cameron Highlands Pit Viper from Malaysia: Insights into Venom Proteome, Toxicity and Neutralization of Antivenom.

Toxins (Basel) 2019 Feb 6;11(2). Epub 2019 Feb 6.

Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

is a montane pit viper that causes bites and envenomation to various communities in the central highland region of Malaysia, in particular Cameron's Highlands. To unravel the venom composition of this species, the venom proteins were digested by trypsin and subjected to nano-liquid chromatography-tandem mass spectrometry (LC-MS/MS) for proteomic profiling. Snake venom metalloproteinases (SVMP) dominated the venom proteome by 48. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/toxins11020095DOI Listing
February 2019
2 Reads
2.480 Impact Factor

De Novo Assessment and Review of Pan-American Pit Viper Anticoagulant and Procoagulant Venom Activities via Kinetomic Analyses.

Toxins (Basel) 2019 Feb 6;11(2). Epub 2019 Feb 6.

Department of Anesthesiology, University of Arizona College of Medicine, Tucson, AZ 85719, USA.

Snakebite with hemotoxic venom continues to be a major source of morbidity and mortality worldwide. Our laboratory has characterized the coagulopathy that occurs in vitro in human plasma via specialized thrombelastographic methods to determine if venoms are predominantly anticoagulant or procoagulant in nature. Further, the exposure of venoms to carbon monoxide (CO) or -phenylhydroxylamine (PHA) modulate putative heme groups attached to key enzymes has also provided mechanistic insight into the multiple different activities contained in one venom. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/toxins11020094DOI Listing
February 2019
2 Reads

Venom from Russia: Venomics, Bioactivities and Preclinical Assessment of Microgen Antivenom.

Toxins (Basel) 2019 Feb 1;11(2). Epub 2019 Feb 1.

Laboratorio de Venómica Evolutiva y Traslacional, CSIC, Jaime Roig 11, 46010 Valencia, Spain.

The common European adder, , is a medically relevant species, which is widely distributed in Russia and thus, is responsible for most snakebite accidents in Russia. We have investigated the toxic and enzymatic activities and have determined the proteomic composition of its venom. Phospholipases A (PLA₂, 25. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/toxins11020090DOI Listing
February 2019
1 Read

Canine ocular and periocular snakebites requiring enucleation: A report of 19 cases.

Vet Ophthalmol 2019 Feb 4. Epub 2019 Feb 4.

Department of Pathological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin.

Purpose: To describe the clinical and histopathologic features secondary to ocular and periocular snakebites in dogs requiring enucleation.

Methods: Retrospective review of patients with recorded snakebite envenomation from the archives of the Comparative Ocular Pathology Laboratory of Wisconsin (COPLOW) and Texas A&M Veterinary Medical Teaching Hospital (1997-2017). The cases included in this study required witnessed snakebites to the dog by the owner, clinical signs supportive of periocular or ocular envenomation, and/or histopathologic lesions compatible with snakebites. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/vop.12638DOI Listing
February 2019
1 Read

Venomous Bites, Stings, and Poisoning: An Update.

Authors:
David A Warrell

Infect Dis Clin North Am 2019 Mar;33(1):17-38

Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK. Electronic address:

This article discusses the epidemiology, prevention, clinical features, and treatment of venomous bites by snakes, lizards, and spiders; stings by fish, jellyfish, echinoderms, insects, and scorpions; and poisoning by ingestion of fish, turtles, and shellfish. Invertebrate stings cause fatalities by anaphylaxis, secondary to acquired hypersensitivity (Hymenoptera, such as bees, wasps, and ants; and jellyfish), and by direct envenoming (scorpions, spiders, jellyfish, and echinoderms). Simple preventive techniques, such as wearing protective clothing, using a flashlight at night, and excluding venomous animals from sleeping quarters, are of paramount importance to reduce the risk of venomous bites and stings. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.idc.2018.10.001DOI Listing
March 2019
2 Reads

Low accuracy of microscopic hematuria in detecting coagulopathy from Bothrops pit viper bites, Brazilian Amazon.

Clin Toxicol (Phila) 2019 Feb 1:1-3. Epub 2019 Feb 1.

a Instituto de Pesquisa Clínica Carlos Borborema, Fundacão de Medicina Tropical Dr. Heitor Vieira Dourado , Manaus , Brazil.

Introduction: The common lancehead snakes (Bothrops atrox) are responsible for up to 90% of snakebites in the Amazon, especially in remote areas. The prevalence of microhematuria is similar to that of coagulopathy in B. atrox envenomation in the Amazon. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15563650.2018.1560463DOI Listing
February 2019
1 Read

Genus Liparis: A review of its traditional uses in China, phytochemistry and pharmacology.

J Ethnopharmacol 2019 Apr 26;234:154-171. Epub 2019 Jan 26.

Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China. Electronic address:

Ethnopharmacological Relevance: The plants of genus Liparis comprise approximately 428 species worldwide among these species 52 are widely distributed in China. These plants have long been used in China for the treatment of wound bleeding, detoxifying and inflammatory diseases, such as metrorrhagia, hemoptysis, traumatic hemorrhage, snakebite, and pneumonia.

Aim Of This Review: We intend to summarize traditional uses of Liparis spp. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.01.021DOI Listing
April 2019
2 Reads
2.998 Impact Factor

Mechanisms underpinning the permanent muscle damage induced by snake venom metalloprotease.

PLoS Negl Trop Dis 2019 01 29;13(1):e0007041. Epub 2019 Jan 29.

School of Pharmacy, University of Reading, Reading, United Kingdom.

Snakebite is a major neglected tropical health issue that affects over 5 million people worldwide resulting in around 1.8 million envenomations and 100,000 deaths each year. Snakebite envenomation also causes innumerable morbidities, specifically loss of limbs as a result of excessive tissue/muscle damage. Read More

View Article

Download full-text PDF

Source
http://dx.plos.org/10.1371/journal.pntd.0007041
Publisher Site
http://dx.doi.org/10.1371/journal.pntd.0007041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368331PMC
January 2019
9 Reads

L-amino acid oxidase from Bothrops atrox snake venom triggers autophagy, apoptosis and necrosis in normal human keratinocytes.

Sci Rep 2019 Jan 28;9(1):781. Epub 2019 Jan 28.

Cardio-Respiratory Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, SW7 2AZ, London, UK.

Snake venom L-amino acid oxidases (LAAOs) are flavoproteins, which perform diverse biological activities in the victim such as edema, myotoxicity and cytotoxicity, contributing to the development of clinical symptoms of envenomation. LAAO cytotoxicity has been described, but the temporal cascade of events leading to cell death has not been explored so far. This study evaluates the involvement of LAAO in dermonecrosis in mice and its cytotoxic effects in normal human keratinocytes, the major cell type in the epidermis, a tissue that undergoes extensive necrosis at the snakebite site. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-37435-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349910PMC
January 2019

Signals of the Neuropilin-1-MET Axis and Cues of Mechanical Force Exertion Converge to Elicit Inflammatory Activation in Coherent Endothelial Cells.

J Immunol 2019 Mar 28;202(5):1559-1572. Epub 2019 Jan 28.

Institute of Physiological Chemistry and Pathobiochemistry, Westfalian Wilhelm University Münster, 48149 Münster, Germany;

The neuropilin-1 (NRP1)-MET signaling axis regulates the motility of individual endothelial cells (ECs). It is unknown how this signaling pathway affects the endothelial barrier in coherent ECs forming a tight monolayer. We hypothesized that it is involved both in modulation of the endothelial barrier and in EC activation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1801346DOI Listing
March 2019
1 Read

Early pathology in venom-induced consumption coagulopathy by Rhabdophis tigrinus (Yamakagashi snake) envenomation.

Clin Toxicol (Phila) 2019 Jan 28:1-4. Epub 2019 Jan 28.

e Department of Dermatology, Graduate School of Medical Science , Kyushu University , Fukuoka , Japan.

Objective: Rhabdophis tigrinus (Yamakagashi in Japanese) is a venomous non-front-fanged colubroid snake capable of inflicting envenoming with life-threatening defibrinating coagulopathy. However, because of the uncommon incidence of bites and tendency for late development of symptoms/signs, the early effects of the venom on the coagulation system are poorly known.

Case Report: We describe a boy bitten by a wild R. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15563650.2018.1540045DOI Listing
January 2019
2 Reads

Wild banana [Ensete superbum (Roxb.) Cheesman.]: Ethnomedicinal, phytochemical and pharmacological overview.

J Ethnopharmacol 2019 Apr 25;233:218-233. Epub 2019 Jan 25.

National Innovation Foundation-India (Autonomous Body of Department of Science and Technology, Govt. of India), Grambharti, Amarapur, Gandhinagar, Gujarat 382650, India. Electronic address:

Ethnopharmacological Relevance: Ensete superbum (Roxb.) Cheesman. (Family: Musaceae), commonly known as "Wild Banana" is well recorded as popular ethnomedicine for medicinal and nutritional uses by different people and communities native to India, Ethiopia, Thailand, Myanmar and Vietnam. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03788741183297
Publisher Site
http://dx.doi.org/10.1016/j.jep.2018.12.048DOI Listing
April 2019
5 Reads

Fasciotomy in compartment syndrome from snakebite.

Arch Plast Surg 2019 Jan 15;46(1):69-74. Epub 2019 Jan 15.

Department of Plastic and Reconstructive Surgery, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea.

Background: Local symptoms and signs of snake envenomation mimic the clinical features of compartment syndrome. It is important to measure the intracompartmental pressure to diagnose compartment syndrome. In this study, we present our experiences of confirming compartment syndrome and performing fasciotomy in snakebite patients based on high intracompartmental pressure findings. Read More

View Article

Download full-text PDF

Source
http://e-aps.org/journal/view.php?doi=10.5999/aps.2018.00577
Publisher Site
http://dx.doi.org/10.5999/aps.2018.00577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369054PMC
January 2019
8 Reads

Search for efficient inhibitors of myotoxic activity induced by ophidian phospholipase A-like proteins using functional, structural and bioinformatics approaches.

Sci Rep 2019 Jan 24;9(1):510. Epub 2019 Jan 24.

Depto. de Física e Biofísica, Instituto de Biociências, UNESP - Universidade Estadual Paulista, Botucatu, SP, Brazil.

Ophidian accidents are considered an important neglected tropical disease by the World Health Organization. Particularly in Latin America, Bothrops snakes are responsible for the majority of the snakebite envenomings that are not efficiently treated by conventional serum therapy. Thus, the search for simple and efficient inhibitors to complement this therapy is a promising research area, and a combination of functional and structural assays have been used to test candidate ligands against specific ophidian venom compounds. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-36839-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346006PMC
January 2019
1 Read

A multi-sectorial approach for addressing the problem of snakebite envenoming in Honduras.

Toxicon 2019 03 21;159:61-62. Epub 2019 Jan 21.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, Costa Rica.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxicon.2019.01.005DOI Listing
March 2019
3 Reads
2.492 Impact Factor

Research into the Causes of Venom-Induced Mortality and Morbidity Identifies New Therapeutic Strategies.

Am J Trop Med Hyg 2019 Jan 21. Epub 2019 Jan 21.

DOS in Biochemistry, University of Mysore, Mysuru, India.

Snakebite primarily affects rural subsistent farming populations in underdeveloped and developing nations. The annual number of deaths (100,000) and physical disabilities (400,000) of snakebite victims is a societal tragedy that poses a significant added socioeconomic burden to the society. Antivenom therapy is the treatment of choice for snakebite but, as testified by the continuing high rates of mortality and morbidity, too many rural tropical snakebite victims fail to access effective treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4269/ajtmh.17-0877DOI Listing
January 2019
7 Reads

Necrotizing fasciitis with mediastinitis following snakebite envenomation.

SAGE Open Med Case Rep 2019 9;7:2050313X18823090. Epub 2019 Jan 9.

Department of Surgery, Arthur Davison Children's Hospital, Ndola, Zambia.

Snakebite envenomation is a life-threatening injury and a neglected public health issue in Africa. We report the case of a child that presented 6 days following a forearm snakebite with compartment syndrome and necrotizing fasciitis of the upper limb extending to the neck and chest who developed mediastinitis. She underwent multiple surgical debridements and the mediastinitis was managed non-surgically with antibiotics and postural drainage leading to recovery. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/2050313X18823090
Publisher Site
http://dx.doi.org/10.1177/2050313X18823090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329015PMC
January 2019
7 Reads

The timing is right to end snakebite deaths in South Asia.

BMJ 2019 Jan 22;364:k5317. Epub 2019 Jan 22.

Department of Tropical Medicine and Public Health, Institute of Occupational Medicine, Social Medicine and Environmental Medicine, Goethe University Frankfurt, Germany.

View Article

Download full-text PDF

Source
http://www.bmj.com/lookup/doi/10.1136/bmj.k5317
Publisher Site
http://dx.doi.org/10.1136/bmj.k5317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340368PMC
January 2019
5 Reads

The time is now: a call for action to translate recent momentum on tackling tropical snakebite into sustained benefit for victims.

Trans R Soc Trop Med Hyg 2019 Jan 21. Epub 2019 Jan 21.

Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK.

Like the other WHO-listed Neglected Tropical Diseases (NTDs), snakebite primarily affects rural, impoverished tropical communities that lack adequate health resources. The annual 138 000 deaths and 400 000 disabilities suffered by these subsistence farming communities means that snakebite is an additional cause and consequence of tropical poverty. Unlike most of the NTDs, however, snakebite is a medical emergency, and requires rapid treatment in a hospital equipped with effective antivenom, beds and appropriately trained staff. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/trstmh/try134DOI Listing
January 2019

Neurotoxic envenomation by the South African coral snake (Aspidelaps lubricus): A case report.

Toxicon 2019 Mar 17;159:38-40. Epub 2019 Jan 17.

Division of Medical Toxicology, Department of Emergency Medicine, University of Pittsburgh School of Medicine, Iroquois Building Suite 400, 3600 Forbes Ave, Pittsburgh, PA 15213, USA. Electronic address:

The South African coral snake (Aspidelaps lubricus, Elapidae) has not previously been reported to cause any neurotoxic envenomations in humans. We recently treated a 44-year-old man who was bitten twice, once in each hand, by a captive South African coral snake (Aspidelaps lubricus) while feeding the female snake who had recently laid eggs. Approximately one hour after receiving the bite, he developed vomiting, respiratory failure requiring mechanical ventilation, and paralysis of the bulbar and upper extremity muscles, with retention of voluntary motor control in the lower extremities. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00410101193001
Publisher Site
http://dx.doi.org/10.1016/j.toxicon.2019.01.001DOI Listing
March 2019
12 Reads

Snakebite accidents in Rio Grande do Norte state, Brazil: Epidemiology, health management and influence of the environmental scenario.

Trop Med Int Health 2019 Jan 19. Epub 2019 Jan 19.

Curso de Doutorado em Desenvolvimento e Meio Ambiente, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.

Objectives: Brazil is home to large variety of snake species, of which about 17% are venomous. A large proportion of reported snakebite accidents in the country take place in northeast Brazil. We aimed to analyse the epidemiology of snakebites as a public health concern in Rio Grande do Norte state. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/tmi.13207
Publisher Site
http://dx.doi.org/10.1111/tmi.13207DOI Listing
January 2019
9 Reads

Toxin Neutralization Using Alternative Binding Proteins.

Toxins (Basel) 2019 Jan 17;11(1). Epub 2019 Jan 17.

Department of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark.

Animal toxins present a major threat to human health worldwide, predominantly through snakebite envenomings, which are responsible for over 100,000 deaths each year. To date, the only available treatment against snakebite envenoming is plasma-derived antivenom. However, despite being key to limiting morbidity and mortality among snakebite victims, current antivenoms suffer from several drawbacks, such as immunogenicity and high cost of production. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/toxins11010053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356946PMC
January 2019
3 Reads

Naja annulifera Snake: New insights into the venom components and pathogenesis of envenomation.

PLoS Negl Trop Dis 2019 01 18;13(1):e0007017. Epub 2019 Jan 18.

Immunochemistry Laboratory, Butantan Institute, São Paulo, Brazil.

Background: Naja annulifera is a medically important venomous snake occurring in some of the countries in Sub-Saharan Africa. Accidental bites result in severe coagulation disturbances, systemic inflammation and heart damage, as reported in dogs, and death, by respiratory arrest, in humans. Despite the medical importance of N. Read More

View Article

Download full-text PDF

Source
http://dx.plos.org/10.1371/journal.pntd.0007017
Publisher Site
http://dx.doi.org/10.1371/journal.pntd.0007017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338361PMC
January 2019
7 Reads

Circulating microvesicles in snakebite patients with microangiopathy.

Res Pract Thromb Haemost 2019 Jan 22;3(1):121-125. Epub 2018 Nov 22.

School of Medicine and Public Health University of Newcastle Newcastle New South Wales Australia.

Background: Venom-induced consumption coagulopathy is a common consequence of snake envenoming that can lead to life-threatening hemorrhage, and is associated with microangiopathic hemolytic anemia (MAHA), acute kidney injury and thrombocytopenia. The role of microvesicles (MV) in snakebite patients has not been previously investigated.

Objective: To compare changes in subsets of circulating MV levels in snakebite patients with venom induced consumption coagulopathy and with or without microangiopathic hemolysis to those of healthy controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/rth2.12164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332827PMC
January 2019
4 Reads

Venom concentrations in blisters and hemorrhagic bullae in a patient bitten by a Taiwan habu (Protobothrops mucrosquamatus).

Rev Soc Bras Med Trop 2019 Jan 17;52:e20180160. Epub 2019 Jan 17.

Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/0037-8682-0160-2018DOI Listing
January 2019
5 Reads

Popular names for bushmaster (Lachesis muta) and lancehead (Bothrops atrox) snakes in the Alto Juruá region: repercussions for clinical-epidemiological diagnosis and surveillance.

Rev Soc Bras Med Trop 2019 01 17;52:e20180140. Epub 2019 Jan 17.

Programa de Pós-Graduação Bionorte - Universidade Federal do Acre - UFAC, Rio Branco, Acre, Brasil.

Introduction: The popular names "surucucu" and "jararaca" have been used in literature for Lachesis muta and Bothrops atrox snakes, respectively. We present the popular names reported by patients who suffered snakebites in the Alto Juruá region.

Methods: Fifty-seven (76%) patients saw the snakes that caused the envenomations and were asked about their popular names and sizes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/0037-8682-0140-2018DOI Listing
January 2019
1 Read

Friends or Foes? Emerging Impacts of Biological Toxins.

Trends Biochem Sci 2019 Apr 14;44(4):365-379. Epub 2019 Jan 14.

Food Safety Group, Cefas, Barrack Road, The Nothe, Weymouth, Dorset DT4 8UB, UK.

Toxins are substances produced from biological sources (e.g., animal, plants, microorganisms) that have deleterious effects on a living organism. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09680004183026
Publisher Site
http://dx.doi.org/10.1016/j.tibs.2018.12.004DOI Listing
April 2019
7 Reads

Snakebite envenoming.

Lancet 2019 01;393(10167):131

Bawaskar Hospital and Clinical Research Center, Mahad 402301, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0140-6736(18)32745-4DOI Listing
January 2019

Snakebite envenoming.

Lancet 2019 01;393(10167):129-131

University of Namibia, Windhoek 93Q5+48, Namibia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0140-6736(18)32762-4DOI Listing
January 2019

Clinical and laboratory features distinguishing between and envenomation.

J Venom Anim Toxins Incl Trop Dis 2018 27;24:43. Epub 2018 Dec 27.

5Department of Emergency Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, No. 539, Zhongxiao Road, East District, Chiayi City, 600 Taiwan.

Background: There are 6 species of venomous snakes in Taiwan. Two of them, () and (), can cause significant coagulopathy. However, a significant proportion of patients with snakebites cannot identify the correct snake species after envenomation, which hampers the application of antivenom. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40409-018-0179-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307318PMC
December 2018
2 Reads

Morphometric characteristics and seasonal proximity to water of the Cypriot blunt-nosed viper (Linnaeus, 1758).

J Venom Anim Toxins Incl Trop Dis 2018 27;24:42. Epub 2018 Dec 27.

2Faculty of Forest Sciences and Forest Ecology, Department of Ecoinformatics, Biometrics and Forest Growth, University of Göttingen, Büsgenweg 4, 37077 Göttingen, Germany.

Background: The blunt-nosed viper (Linnaeus, 1758) is a medically important snake species in the Middle East. Its nominate subspecies is confined to Cyprus, where it is the only dangerously venomous snake species and heavily pursued. Despite the viper's large size, data on its body mass and sex-specific morphological differences are scarce. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40409-018-0175-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307313PMC
December 2018
1 Read

Next-generation sequencing analysis reveals high bacterial diversity in wild venomous and non-venomous snakes from India.

J Venom Anim Toxins Incl Trop Dis 2018 22;24:41. Epub 2018 Dec 22.

Department of Forests and Wildlife, Sulthan Batheri, Wayanad District, Kerala 673592 India.

Background: The oral cavities of snakes are replete with various types of bacterial flora. Culture-dependent studies suggest that some of the bacterial species are responsible for secondary bacterial infection associated with snakebite. A complete profile of the ophidian oral bacterial community has been unreported until now. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40409-018-0181-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303853PMC
December 2018
3 Reads

Snakebite burden in Sub-Saharan Africa: estimates from 41 countries.

Toxicon 2019 Mar 27;159:1-4. Epub 2018 Dec 27.

Infectious & Tropical Diseases Unit, Aminu Kano Teaching Hospital, Bayero University, Kano, Nigeria. Electronic address:

There is no reliable estimate of burden of snakebite-envenoming (SBE) in Sub-Saharan Africa (SSA). We derived from a meta-analysis the burden of SBE related deaths, amputations and Post-Traumatic Stress Disorder (PTSD) in 41 countries in SSA. The annual burden was estimated at 1. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00410101183118
Publisher Site
http://dx.doi.org/10.1016/j.toxicon.2018.12.002DOI Listing
March 2019
13 Reads