52,854 results match your criteria Smoke Inhalation


Cigarette Smoke Extract Promotes TIM4 Expression in Murine Dendritic Cells Leading to Th2 Polarization through ERK-Dependent Pathways.

Int Arch Allergy Immunol 2018 Dec 6:1-10. Epub 2018 Dec 6.

Laboratory of Clinical Immunology, Wuhan No. 1 Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan,

Smoking is considered to be the main source of indoor pollution, and it has been identified as an important environmental factor contributing to asthma onset. We know that T helper 2 (Th2) response plays a crucial role in the process of asthma disease. We have investigated the reaction of cigarette smoke extract (CSE) on Th polarization which is controlled by dendritic cells (DCs). Read More

View Article
December 2018
1 Read

Enhancing effects of acute exposure to cannabis smoke on working memory performance.

Neurobiol Learn Mem 2018 Dec 3. Epub 2018 Dec 3.

Department of Psychiatry, University of Florida, Gainesville, FL, USA; Department of Neuroscience, University of Florida, Gainesville, FL, USA; Center for Addiction Research and Education, University of Florida, Gainesville, FL, USA; Department of Psychology, University of Florida, Gainesville, FL, USA. Electronic address:

Numerous preclinical studies show that acute cannabinoid administration impairs cognitive performance. Almost all of this research has employed cannabinoid injections, however, whereas smoking is the preferred route of cannabis administration in humans. The goal of these experiments was to systematically determine how acute exposure to cannabis smoke affects working memory performance in a rat model. Read More

View Article
December 2018
3 Reads

Sex differences in stress reactivity after intranasal oxytocin in recreational cannabis users.

Pharmacol Biochem Behav 2018 Dec 3. Epub 2018 Dec 3.

New York State Psychiatric Institute, New York, NY, United States of America; Columbia University Medical Center, New York, NY, United States of America.

Cannabis is the most widely used illicit drugs and the changing legal, political and cultural climate will likely increase cannabis use further. One factor that may underlie the transition from recreational use to problematic use is stress. The hormone oxytocin (OXT) modulates stress and may have therapeutic efficacy for substance use disorders, but few studies have examined OXT in cannabis users. Read More

View Article
December 2018
2 Reads

Exposure to Secondhand Smoke Among Nonsmokers - United States, 1988-2014.

MMWR Morb Mortal Wkly Rep 2018 Dec 7;67(48):1342-1346. Epub 2018 Dec 7.

Exposure to secondhand smoke from burning tobacco products can cause sudden infant death syndrome, respiratory infections, ear infections, and asthma attacks in infants and children, and coronary heart disease, stroke, and lung cancer in adult nonsmokers (1). There is no risk-free level of secondhand smoke exposure (2). CDC analyzed questionnaire and laboratory data from the National Health and Nutrition Examination Survey (NHANES) to assess patterns of secondhand smoke exposure among U. Read More

View Article
December 2018
2 Reads

Pediatric Office Delivery of Smoking Cessation Assistance for Breast-Feeding Mothers.

Nicotine Tob Res 2018 Dec 6. Epub 2018 Dec 6.

Division of General Academic Pediatrics, Department of Pediatrics, Massachusetts General Hospital for Children, Boston, MA.

Introduction: National and international organizations have done an excellent job of advocating and promoting breast feeding for all mothers. This study assessed to what extent an intervention increased delivery of cessation assistance to breast-feeding mothers who smoke.

Methods: Data were collected between April and October 2015 in five US states as part of a cluster randomized controlled trial in 10 pediatric practices. Read More

View Article
December 2018
1 Read

A Functional Macrophage Migration Inhibitory Factor (MIF) Promoter Polymorphism is Associated with Reduced Diffusing Capacity.

Am J Physiol Lung Cell Mol Physiol 2018 Dec 6. Epub 2018 Dec 6.

Pulmonary and Critical Care, Yale University School of Medicine, United States.

Cigarette smoke exposure is the leading modifiable risk factor for COPD, however the clinical and pathologic consequences of chronic cigarette smoke exposure are variable amongst smokers. MIF (Macrophage Migration Inhibitory Factor) is a pleiotropic cytokine implicated in the pathogenesis of Chronic Obstructive Pulmonary Disease (COPD). Within the promoter of the MIF gene is a functional polymorphism that regulates MIF expression (-794 CATT microsatellite repeat) ( rs5844572). Read More

View Article
December 2018

Are We Justified in Introducing Carbon Monoxide Testing to Encourage Smoking Cessation in Pregnant Women?

Authors:
Catherine Bowden

Health Care Anal 2018 Dec 5. Epub 2018 Dec 5.

School of Law, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK.

Smoking is frequently presented as being particularly problematic when the smoker is a pregnant woman because of the potential harm to the future child. This premise is used to justify targeting pregnant women with a unique approach to smoking cessation including policies such as the routine testing of all pregnant women for carbon monoxide at every antenatal appointment. This paper examines the evidence that such policies are justified by the aim of harm prevention and argues that targeting pregnant women in this way is likely to do more harm than good. Read More

View Article
December 2018

Evaluation of fiber optic methane sensor using a smoke chamber.

Int J Min Sci Technol 2018 Nov;28(6):969-974

National Institute for Occupational Safety and Health, Pittsburgh Mining Research Division, Pittsburgh 15236, USA.

This report presents the results of experiments to evaluate a prototype fiber optic methane monitor exposed to smoke using a smoke chamber to simulate atmospheric conditions in an underground coal mine after a fire or explosion. The experiments were conducted using test fires of different combustible sources commonly found in mines -douglas-fir wood, SBR belt, and Pittsburgh seam coal. The experiments were designed to assess the response of the fiber optic methane sensor to different contaminants, different contaminant levels and different contaminant durations produced from the test fires. Read More

View Article
November 2018

Walking activity during ambulant cardiac rehabilitation is related to maximum working capacity, age, and smoking behavior.

Vasc Health Risk Manag 2018 9;14:361-369. Epub 2018 Nov 9.

Institute of Sports and Preventive Medicine, Saarbrücken, Germany,

Background: A total of 6,500 to 8,000 steps per day are recommended for cardiovascular secondary prevention. The aim of this research was to examine how many steps per day patients achieve during ambulant cardiac rehabilitation (CR), and if there is a correlation between the number of steps and physical and cardiological parameters.

Methods: In all, 192 stable CR patients were included and advised for sealed pedometry. Read More

View Article
November 2018

Mitochondrial functioning abnormalities observed in blood platelets of chronic smoke-exposed guinea pigs - a pilot study.

Int J Chron Obstruct Pulmon Dis 2018 9;13:3707-3717. Epub 2018 Nov 9.

Department of Pneumology and Allergy, Medical University of Lodz, Lodz, Poland,

Background: COPD represents a major global health issue, which is often accompanied by cardiovascular diseases. A considerable body of evidence suggests that cardiovascular risk is elevated by the activation of blood platelets, which in turn is exacerbated by inflammation. As reactive oxygen species are believed to be an important factor in platelet metabolism and functioning, the aim of our study was to perform a complex assessment of mitochondrial function in platelets in chronic smoke exposed animals with COPD-like lung lesions. Read More

View Article
November 2018

[Awareness of harm to others from secondhand smoke and smokers' interest in smoking cessation].

Nihon Koshu Eisei Zasshi 2018 ;65(11):655-665

Cancer Control Center, Osaka International Cancer Institute.

Objectives Because smoking presents various health hazards, smoking cessation is important for health promotion. It is known that awareness of the harm of smoking to smokers themselves is associated with attempts to quit. However, the association between smoking cessation and awareness of harm to others from secondhand smoke has not been well examined. Read More

View Article
January 2018
6 Reads

[COPD due to Occupational Noxae].

Authors:
X Baur

Pneumologie 2018 Dec 3. Epub 2018 Dec 3.

Universitätsklinikum Hamburg-Eppendorf, ehem. Lehrstuhl Arbeitsmedizin und Maritime Medizin; European Society for Environmental und Occupational Medicine (EOM Society).

The chronic obstructive pulmonary disease (COPD) is characterised by mainly non-reversible bronchial obstruction with airflow limitation. Typically, it exhibits a progressive course. It is one of the leading causes of morbidity and mortality worldwide. Read More

View Article
December 2018

Human AHR functions in vascular tissue: Pro- and anti-inflammatory responses of AHR agonists in atherosclerosis.

Authors:
Karl Walter Bock

Biochem Pharmacol 2018 Nov 30. Epub 2018 Nov 30.

Department of Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Wilhelmstrasse 56, D-72074 Tübingen, Germany.

Despite decades of intense research physiologic aryl hydrocarbon receptor (AHR) functions have not been elucidated. Challenges include marked species differences and dependence on cell type and cellular context. A previous commentary on human AHR functions in skin and intestine has been extended to vascular tissue. Read More

View Article
November 2018

Correlation between Glyoxal-Induced DNA Cross-Links and Hemoglobin Modifications in Human Blood Measured by Mass Spectrometry.

Chem Res Toxicol 2018 Dec 3. Epub 2018 Dec 3.

Glyoxal is an oxoaldehyde generated from the degradation of glucose-protein conjugates and from lipid peroxidation in foods and in vivo, and it is also present in the environment (e.g. cigarette smoke). Read More

View Article
December 2018

Assessment of age-related differences in smoking status and health-related quality of life (HRQoL): Findings from the 2016 Behavioral Risk Factor Surveillance System.

J Community Psychol 2019 Jan 10;47(1):93-103. Epub 2018 Jul 10.

National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, US Centers for Disease Control and Prevention.

Despite significant declines in the use of cigarettes, a significant proportion of adults smoke. This study explores the association between smoking and health-related quality of life (HRQoL) by age. The 2016 Behavioral Risk Factor Surveillance System survey was administered to adults in 50 states and District of Columbia (n = 437,195). Read More

View Article
January 2019

Feasibility of a proactive text messaging intervention for smokers in community health centers.

JMIR Form Res 2018 Jan-Jun;2(1). Epub 2017 Dec 8.

Division of General Internal Medicine, Department of Medicine, Massachusetts General Hospital.

Introduction: Few smokers receive evidence-based cessation services during primary care visits. We aimed to assess the feasibility of a proactive text messaging program for primary care patients who smoke.

Methods: We used electronic health records (EHRs) to identify smokers from two Massachusetts community health centers who had a mobile phone number listed. Read More

View Article
December 2017

Cognizance and social attitudes regarding tobacco control laws in and around educational institutions of Nellore city, India.

J Educ Health Promot 2018 29;7:125. Epub 2018 Oct 29.

Department of Periodontics, Narayana Dental College and Hospital, Nellore, Andhra Pradesh, India.

Introduction: Indian national law namely Cigarettes and Other Tobacco Products Act (COTPA) exists since 2003 and aims at protecting all the people in our country, but smoking is still prevalent among people. This study was aimed to assess awareness, attitudes, and practices regarding prohibition of sale of tobacco products near educational institutions of Nellore city, India.

Materials And Methods: A descriptive cross-sectional study was conducted in degree colleges of Nellore city of Andhra Pradesh. Read More

View Article
October 2018

Inhalation lung injury induced by smoke bombs in children: CT manifestations, dynamic evolution features and quantitative analysis.

J Thorac Dis 2018 Oct;10(10):5860-5869

Department of Radiology, Gansu Provincial Hospital, Lanzhou 713000, China.

Background: This retrospective study aimed to investigate the computed tomography (CT) manifestations, short-term dynamic evolution features and quantitative lung CT analysis of inhalation lung injury induced by smoke bomb flare.

Methods: Eleven pediatric patients (aged 11 to 13) who inhaled the smoke of smoke bombs underwent several low-dose chest CT scans. The image characteristics and their dynamic changes were observed and quantitative CT values were analyzed. Read More

View Article
October 2018

Tobacco use among Latinx adolescents: exploring the immigrant paradox.

BMC Pediatr 2018 Nov 30;18(1):379. Epub 2018 Nov 30.

Division of General Pediatrics, Boston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA.

Background: Research suggests that an immigrant paradox exists where those who were not born in the United States (1 generation) have significantly better health than those who were born in the U.S. (2 generation or more). Read More

View Article
November 2018

Biomarkers of Exposure to Secondhand and Thirdhand Tobacco Smoke: Recent Advances and Future Perspectives.

Int J Environ Res Public Health 2018 Nov 29;15(12). Epub 2018 Nov 29.

Department of Electronic Engineering, Universitat Rovira i Virgili, Països Catalans 26, 43007 Tarragona, Spain.

Smoking is the leading preventable disease worldwide and passive smoking is estimated to be the cause of about 1.0% of worldwide mortality. The determination of tobacco smoke biomarkers in human biological matrices is key to assess the health effects related to the exposure to environmental tobacco smoke. Read More

View Article
November 2018

Magnitude and Chronicity of Environmental Smoke Exposure Across Infancy and Early Childhood in a Sample of Low-Income Children.

Nicotine Tob Res 2018 Dec 5. Epub 2018 Dec 5.

Department of Applied Psychology, New York University, New York, NY.

Introduction: Infants and young children may be at an increased risk for second- and thirdhand exposure to tobacco smoke because of increased respiration rate and exposure to surface residue. However, relatively fewer studies have examined biomarkers of exposure (cotinine) in children under age 4 years. This study examines the magnitude and chronicity of exposure across early childhood among children from low-income families in order to better characterize contextual risk factors associated with exposure. Read More

View Article
December 2018
11 Reads

Disseminating a Smoke Free Homes program to low SES households in the US through 2-1-1: Results of a national impact evaluation.

Nicotine Tob Res 2018 Dec 5. Epub 2018 Dec 5.

Brown School, Washington University, St. Louis MO.

Introduction: Given homes are now a primary source of secondhand smoke exposure (SHS) in the US, research-tested interventions that promote smoke-free homes should be evaluated in real-world settings to build the evidence-base for dissemination. This study describes outcome evaluation results from a dissemination and implementation study of a research-tested program to increase smoke-free home rules through US 2-1-1 helplines.

Methods: Five 2-1-1 organizations, chosen through a competitive application process, were awarded grants of up to $70,000. Read More

View Article
December 2018
1 Read

Sarcopenia and its association with changes in socioeconomic, behavioral, and health factors: the EpiFloripa Elderly Study.

Cad Saude Publica 2018 Nov 29;34(12):e00164917. Epub 2018 Nov 29.

Universidade Federal de Santa Catarina, Florianópolis, Brasil.

This study aimed to verify the prevalence of sarcopenia and its association with changes in socioeconomic, behavioral, and health factors in the elderly. The longitudinal population-based study included 598 elderly (≥ 60 years) in Florianópolis, Santa Catarina State, in the South of Brazil. Sarcopenia was defined on the basis of appendicular skeletal mass index (ASMI) according to gender (ASMI < 7. Read More

View Article
November 2018
1 Read

Novel pharmacotherapy for burn wounds: what are the advancements.

Expert Opin Pharmacother 2018 Dec 5:1-17. Epub 2018 Dec 5.

a Wellman Center for Photomedicine , Massachusetts General Hospital , Boston , MA , USA.

Introduction: The prognosis for severe burns has improved significantly over the past 50 years. Meanwhile, burns have become an affliction mainly affecting the less well-developed regions of the world. Early excision and skin grafting has led to major improvements in therapeutic outcomes. Read More

View Article
December 2018
5 Reads

The toxicology of air pollution predicts its epidemiology.

Inhal Toxicol 2018 Dec 5:1-8. Epub 2018 Dec 5.

a The National Health and Environmental Effects Research Laboratory , Environmental Protection Agency , Chapel Hill , NC , USA.

The epidemiologic investigation has successively delineated associations of air pollution exposure with non-malignant and malignant lung disease, cardiovascular disease, cerebrovascular disease, pregnancy outcomes, perinatal effects and other extra-pulmonary disease including diabetes. Defining these relationships between air pollution exposure and human health closely parallels results of an earlier epidemiologic investigation into cigarette smoking and environmental tobacco smoke (ETS), two other particle-related exposures. Humic-like substances (HULIS) have been identified as a chemical component common to cigarette smoke and air pollution particles. Read More

View Article
December 2018
5 Reads

The role of environmental exposure to non-cigarette smoke in lung disease.

Clin Transl Med 2018 Dec 5;7(1):39. Epub 2018 Dec 5.

School of Medicine, College of Health and Medicine, University of Tasmania, Hobart, Tasmania, Australia.

Chronic exposure to household indoor smoke and outdoor air pollution is a major contributor to global morbidity and mortality. The majority of these deaths occur in low and middle-income countries. Children, women, the elderly and people with underlying chronic conditions are most affected. Read More

View Article
December 2018

Evidence of a Causal Relationship Between Smoking Tobacco and Schizophrenia Spectrum Disorders.

Front Psychiatry 2018 20;9:607. Epub 2018 Nov 20.

Center for Life Course Health Research, University of Oulu, Oulu, Finland.

There has been emerging evidence of an association between tobacco smoking and schizophrenia spectrum disorders (SSD). Two meta-analyses have reported that people who smoke tobacco have an ~2-fold increased risk of incident schizophrenia or psychosis, even after adjusting for confounding factors. This study aimed to critically appraise the research which has examined the association between tobacco smoking and SSD against the Bradford Hill criteria for causality, to determine the strength of the evidence for a causal relationship. Read More

View Article
November 2018
1 Read

Women with COPD by biomass show different serum profile of adipokines, incretins, and peptide hormones than smokers.

Respir Res 2018 Dec 4;19(1):239. Epub 2018 Dec 4.

Departamento de Investigación en Fibrosis Pulmonar, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas (INERICV), Talpan 4502, C.P. 14080, Ciudad de México, Mexico.

Background: The main causes of COPD are tobacco smoking (COPD-TS) and biomass smoke exposure (COPD-BS). COPD-TS is known to induce changes in adipokines, incretins, and peptide hormones, frequent biomarkers of inflammation; however, it is unknown if similar changes occur in COPD-BS.

Methods: Clinical and physiological characteristics, and serum concentration of C-peptide, ghrelin, GIP, GLP-1, glucagon, insulin, leptin, PAI-1, resistin, and visfatin were measured in women with COPD-BS, COPD-TS, and healthy controls. Read More

View Article
December 2018

Epidemiology of asthma and associated factors in an urban Pakistani population: adult asthma study-Karachi.

BMC Pulm Med 2018 Dec 4;18(1):184. Epub 2018 Dec 4.

Respiratory Epidemiology and Public Health, National Heart & Lung Institute, Imperial College London, London, UK.

Background: This study was conducted in order to determine the prevalence of asthma and associated risk factors in the adult population of Karachi, Pakistan.

Methods: This multi-stage, cross-sectional survey was conducted from May 2014-August 2015; comprising 1629 adults in 75 randomly selected clusters in Karachi, Pakistan. Definitions included: 'self-reported asthma', 'reversibility in FEV and 'respiratory symptoms and reversibility in FEV'. Read More

View Article
December 2018

Influence of Active Exposure to Tobacco Smoke on Nitric Oxide Status of Pregnant Women.

Int J Environ Res Public Health 2018 Dec 3;15(12). Epub 2018 Dec 3.

Department of Obstetrics and Gynaecology, Institute of Mother and Child, 01-211 Warsaw, Poland.

Smoking tobacco can impair proper vascular endothelial functioning. This is exhibited through reduced nitric oxide synthesis as well as activity due to accompanying oxidative stress. We examined the relationship between nitric oxide and markers of oxidative stress/antioxidant defense in serum of smoking and non-smoking pregnant women. Read More

View Article
December 2018

Differential exposure to 33 toxic elements through cigarette smoking, based on the type of tobacco and rolling paper used.

Environ Res 2018 Nov 22;169:368-376. Epub 2018 Nov 22.

Toxicology Unit, Research Institute of Biomedical and Health Sciences (IUIBS), Instituto Canario de Investigación del Cáncer (ICIC), Universidad de Las Palmas de Gran Canaria, Paseo Blas Cabrera s/n, 35016 Las Palmas de Gran Canaria, Spain.

Environmental pollution due to various elements is increasing all across the planet owing to their use in industrial processes. The tobacco plants and the vegetables used in the manufacturing of smoking paper may accumulate these elements from the environment. Thus, tobacco and smoking paper may be relevant contributors among the content of elements in cigarettes, including some emerging pollutants such as rare earth elements (REEs). Read More

View Article
November 2018
1 Read

Tobacco smoking between immigrants and non-immigrants in Australia: A longitudinal investigation of the effect of nativity, duration of residence and age at arrival.

Health Promot J Austr 2018 Dec 28;29(3):282-292. Epub 2017 Dec 28.

Alfred Deakin Institute for Citizenship and Globalisation, Deakin University, Burwood, VIC, Australia.

Issue Addressed: Earlier research evidence suggests that there is a difference and over time change in the prevalence of tobacco smoking between immigrants and native-born population. This study investigates the differences in smoking among immigrants from English speaking (ESC) and non-English speaking (NESC) countries relative to native-born (NB) Australians, and how those differences change with duration of residence (DoR) and age at arrival (AA).

Methods: Information on 12 634 individuals from the first twelve waves (2001-2012) of Household, Income and Labour Dynamics in Australia (HILDA) longitudinal survey was analysed using multilevel group-mean-centred mixed logistic regression models. Read More

View Article
December 2018
1 Read

Influence of maturity, smoking, and drying of fresh maize on sensory acceptability and nutritional content of the developed porridges.

Food Sci Nutr 2018 Nov 10;6(8):2402-2413. Epub 2018 Oct 10.

Department of Food Science and Technology Lilongwe University of Agriculture and Natural Resources Lilongwe Malawi.

This study investigated the potential of using the underutilized fresh maize in the preparation of porridge to contribute toward complementary feeding of children, and reductions in pre-harvest losses. Fresh maize was harvested at different stages of maturity, blanched, smoked, and sun dried before milling into flours that were blended with soy flours for preparation of test porridges. The test flours were analyzed using the Association of the Official Analytical Chemists (AOAC) methods to determine their nutrient composition before preparation of the porridges. Read More

View Article
November 2018

Smoking cessation advice after cervical screening: a qualitative interview study of acceptability in Dutch primary care.

Br J Gen Pract 2018 Dec 3. Epub 2018 Dec 3.

Department of General Practice, Amsterdam UMC - Academic Medical Centre, University of Amsterdam, Amsterdam.

Background: Cervical cancer screening in general practice could be a routine and opportune moment to advise females who smoke to stop smoking.

Aim: The aims of this study were to investigate the attitudes of females who smoke to receiving advice about stopping smoking after cervical screening and to identify factors associated with the acceptability of this advice.

Design And Setting: This qualitative interview study was conducted with Dutch females who smoked, had undergone cervical screening, and were aged 30 to 60 years. Read More

View Article
December 2018
1 Read

Naturalizing pollution: a critical social science view on the link between potash mining and salinization in the Llobregat river basin, northeast Spain.

Philos Trans R Soc Lond B Biol Sci 2018 Dec 3;374(1764). Epub 2018 Dec 3.

Departament de Geografia, Universitat Autònoma de Barcelona, Bellaterra, Catalunya, Spain.

The scientific literature distinguishes between primary or natural and secondary or human-induced salinization. Assessing this distinction is of vital importance to assign liabilities and responsibilities in pollution cases and for designing the best policy and management actions. In this context, actors interested in downplaying the role of certain drivers of human-induced salinization can attempt to neglect its importance by referring to natural salinization, in a similar fashion to other pollution and health-related cases, from tobacco smoke to climate change. Read More

View Article
December 2018

Air pollution, environmental chemicals, and smoking may trigger vitamin D deficiency: Evidence and potential mechanisms.

Environ Int 2018 Nov 30. Epub 2018 Nov 30.

Centre for Environment and Health, Department of Public Health and Primary Care, University of Leuven (KU, Leuven), Belgium; IDEWE, External Service for Prevention at Protection at Work, Heverlee, Belgium.

Beyond vitamin D (VD) effect on bone homeostasis, numerous physiological functions in human health have been described for this versatile prohormone. In 2016, 95% of the world's population lived in areas where annual mean ambient particulate matter (<2.5 μm) levels exceeded the World Health Organization guideline value (Shaddick et al. Read More

View Article
November 2018
1 Read

LncRNA LCPAT1 is involved in DNA damage induced by CSE.

Biochem Biophys Res Commun 2018 Nov 30. Epub 2018 Nov 30.

Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. Electronic address:

Cigarette smoking plays an important role in the process of lung cancer, during which DNA damage is proved to be involved. Non-coding RNAs are found to be involved in the DNA damage and repair processes induced by cigarette smoke. In the present study, we investigated the role of lncRNA LCPAT1 in DNA damage caused by CSE in Beas-2B cells. Read More

View Article
November 2018

Pursuing reflective equilibrium when hospital patients smoke.

Authors:
Gary Goldsand

Healthc Manage Forum 2018 Dec 3:840470418812108. Epub 2018 Dec 3.

1 Assistant Clinical Professor, John Dossetor Health Ethics Centre, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

Questions about smoking policies in hospitals, and how exactly to implement them, have been difficult to answer for many years. Policy-makers must consider a tangled web of personal versus public goods. Administrators often have to creatively decide how policies can best be adopted at their particular site. Read More

View Article
December 2018

Association of exposure level to passive smoking with hypertension among lifetime nonsmokers in Japan: a cross-sectional study.

Medicine (Baltimore) 2018 Nov;97(48):e13241

Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya.

Brief exposure to passive smoking immediately elevates blood pressure. However, little is known about the association between exposure to passive smoking and chronic hypertension. We aimed to examine this association in a cross-sectional study, after controlling multiple potential confounders. Read More

View Article
November 2018
2 Reads

Synthesis of a novel phosphazene-based flame retardant with active amine groups and its application in reducing the fire hazard of Epoxy Resin.

J Hazard Mater 2018 Nov 23;366:78-87. Epub 2018 Nov 23.

Key Laboratory of Analytical Science and Technology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding, 071002, China. Electronic address:

A novel compound containing active amine groups of polyphosphazene (PBFA) was successfully synthesized and applied as a reactive flame-retardant additive in epoxy (EP) resin. It was synthesized from N-aminoethylpiperazine and hexachlorocyclotriphosphazene using a simple method, and its structure was well-characterized. The results indicated that introducing PBFA into EP composites significantly improves the resistance to fire and suppresses smoke generation. Read More

View Article
November 2018
1 Read

Transcriptional Activity of Human Endogenous Retroviruses in Response to Prenatal Exposure of Maternal Cigarette Smoking.

Am J Perinatol 2018 Nov 30. Epub 2018 Nov 30.

Department of Public Health and Pediatric Sciences, Citoimmunodiagnostics Laboratory, University of Turin, Medical School, Turin, Italy.

Objective:  Transcription of human endogenous retrovirus (HERV) elements is usually suppressed by epigenetic factors such as DNA methylation and heterochromatin silencing by histone modifications. There is an association between maternal smoking during pregnancy and DNA methylation levels in placental tissue and in DNA from cord blood.

Materials And Methods:  We assessed the transcriptional activity of HERV-H, HERV-K, and HERV-W in umbilical cord blood from 47 term babies unexposed to tobacco smoke in utero and 23 term babies exposed to tobacco smoke in utero. Read More

View Article
November 2018

Autophagy augmentation alleviates cigarette smoke-induced CFTR-dysfunction, ceramide-accumulation and COPD-emphysema pathogenesis.

Free Radic Biol Med 2018 Nov 27. Epub 2018 Nov 27.

College of Medicine, Central Michigan University, Mt Pleasant, MI, USA; The Johns Hopkins University SOM University, Baltimore, MD, USA; VIJ Biotech LLC, Baltimore, MD, USA. Electronic address:

In this study, we aimed to investigate precise mechanism(s) of sphingolipid-imbalance and resulting ceramide-accumulation in COPD-emphysema. Where, human and murine emphysema lung tissues or human bronchial epithelial cells (Beas2b) were used for experimental analysis. We found that lungs of smokers and COPD-subjects with increasing emphysema severity demonstrate sphingolipid-imbalance, resulting in significant ceramide-accumulation and increased ceramide/sphingosine ratio, as compared to non-emphysema/non-smoker controls. Read More

View Article
November 2018

Modulation of Peroxynitrite Reduces Norepinephrine Requirements in Ovine MRSA Septic Shock.

Shock 2018 Nov 28. Epub 2018 Nov 28.

Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas.

Vascular hypo-responsiveness to vasopressors during septic shock is a challenging problem. This study is to test the hypothesis that reactive nitrogen species (RNS), such as peroxynitrite, are major contributing factors to vascular hypo-responsiveness in septic shock. We hypothesized that adjunct therapy with peroxynitrite decomposition catalyst (PDC) would reduce norepinephrine requirements in sepsis resuscitation. Read More

View Article
November 2018
3 Reads

Distribution of diabetes, hypertension and non-communicable disease risk factors among adults in rural Bangladesh: a cross-sectional survey.

BMJ Glob Health 2018 12;3(6):e000787. Epub 2018 Nov 12.

Diabetic Association of Bangladesh, Dhaka, Bangladesh.

Background: Non-communicable diseases (NCDs) are increasing in low-income settings. We conducted a survey of risk factors, blood pressure and blood glucose in rural Bangladesh and assessed variations by age, sex and wealth.

Methods: We surveyed a random sample of 12 280 adults aged >30 years in 96 villages in rural Bangladesh. Read More

View Article
November 2018
1 Read

Celastrol Alleviates Chronic Obstructive Pulmonary Disease by Inhibiting Cellular Inflammation Induced by Cigarette Smoke via the Ednrb/Kng1 Signaling Pathway.

Front Pharmacol 2018 15;9:1276. Epub 2018 Nov 15.

Department of Geriatrics, Xiangya Hospital of Central South University, Changsha, China.

Chronic obstructive pulmonary disease (COPD) is a debilitating disease caused by chronic exposure to cigarette smoke (CS). Celastrol is a pentacyclic triterpenoid compound exhibits potent antioxidant and anti-inflammatory activities. Also it is presently known to protect against liver damage induced by type II diabetes. Read More

View Article
November 2018

Silicosis and lung cancer: current perspectives.

Lung Cancer (Auckl) 2018 26;9:91-101. Epub 2018 Oct 26.

Cancer and Inflammation Program, National Cancer Institute, Frederick, MD 21702, USA,

"Silica" refers to crystalline particles formed by the combination of silicon with oxygen. Inhalation of silica particles promotes the development of pulmonary fibrosis that over prolonged periods increases the risk of lung cancer. The International Agency for Research on Cancer (IARC) classified crystalline silica as a human carcinogen in 1997. Read More

View Article
October 2018

The effect of passive smoking on bacterial colonisation of the upper airways and selected laboratory parameters in children.

Acta Otorhinolaryngol Ital 2018 Oct;38(5):431-438

Department of Paediatrics, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, University Hospital, Martin, Slovakia.

Exposure to tobacco smoke is associated with a higher risk of respiratory tract diseases. The aim of this study was to determine the influence of passive smoking on selected characteristics of children with adenoid hypertrophy. Sixty-one children with adenoid hypertrophy were enrolled in the prospective study. Read More

View Article
October 2018

Lack of effect of transcranial direct current stimulation (tDCS) on short-term smoking cessation: Results of a randomized, sham-controlled clinical trial.

Drug Alcohol Depend 2018 Nov 13;194:244-251. Epub 2018 Nov 13.

Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.

Background: Transcranial direct current stimulation (tDCS) has been shown to improve measures of executive cognitive function and reduce cigarette consumption. Studies conducted to date have been small, and the results are mixed.

Methods: This randomized, double-blind, parallel arm clinical trial tested the effects of active anodal tDCS targeted to the left dorsolateral prefrontal cortex (versus sham) on 7-day smoking cessation in 106 treatment-seeking smokers. Read More

View Article
November 2018

The 2016 Tips From Former Smokers® Campaign: Associations With Quit Intentions and Quit Attempts Among Smokers With and Without Mental Health Conditions.

Nicotine Tob Res 2018 Nov 28. Epub 2018 Nov 28.

Office on Smoking and Health, Centers for Disease Control and Prevention, Atlanta, GA.

Introduction: People living with mental health conditions (MH+) are more likely to smoke cigarettes than people without mental health conditions (MH-) and to experience tobacco-related disparities. The Tips From Former Smokers® (Tips®) campaign is a proven population-level strategy for motivating smokers to quit. In 2016, Tips included ads featuring Rebecca, a former smoker with depression. Read More

View Article
November 2018