4,577 results match your criteria Smoke Inhalation


Identification of differentially expressed proteins in the injured lung from zinc chloride smoke inhalation based on proteomics analysis.

Respir Res 2019 Feb 15;20(1):36. Epub 2019 Feb 15.

Department of Respiratory, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.

Background: Lung injury due to zinc chloride smoke inhalation is very common in military personnel and leads to a high incidence of pulmonary complications and mortality. The aim of this study was to uncover the underlying mechanisms of lung injury due to zinc chloride smoke inhalation using a rat model.

Methods: Histopathology analysis of rat lungs after zinc chloride smoke inhalation was performed by using haematoxylin and eosin (H&E) and Mallory staining. Read More

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http://dx.doi.org/10.1186/s12931-019-0995-0DOI Listing
February 2019

A six-month systems toxicology inhalation/cessation study in ApoE mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products, CHTP 1.2 and THS 2.2, compared with conventional cigarettes.

Food Chem Toxicol 2019 Feb 11. Epub 2019 Feb 11.

PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland. Electronic address:

Smoking is one of the major modifiable risk factors in the development and progression of chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD). Modified-risk tobacco products (MRTP) are being developed to provide substitute products for smokers who are unable or unwilling to quit, to lessen the smoking-related health risks. In this study, the ApoE mouse model was used to investigate the impact of cigarette smoke (CS) from the reference cigarette 3R4F, or aerosol from two potential MRTPs based on the heat-not-burn principle, carbon-heated tobacco product 1. Read More

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http://dx.doi.org/10.1016/j.fct.2019.02.008DOI Listing
February 2019

Effect of Age, High-Fat Diet, and Rat Strain on Serum Biomarkers and Telomere Length and Global DNA Methylation in Peripheral Blood Mononuclear Cells.

Sci Rep 2019 Feb 13;9(1):1996. Epub 2019 Feb 13.

Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, 26505, USA.

The objective of the current study was to determine if age, diet, and genetic disposition (animal strain) in an animal model had early effects on specific molecular markers in circulating peripheral blood mononuclear cells (PBMCs). Three strains [Sprague-Dawley (SD), Fischer 344 (F344), and Brown-Norway (BN)] of male rats were maintained on a high-fat (HF) or regular diet. Blood was collected at 4, 12, and 24 wk to assess chemistry and to recover PBMCs. Read More

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http://www.nature.com/articles/s41598-018-38192-0
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http://dx.doi.org/10.1038/s41598-018-38192-0DOI Listing
February 2019
1 Read
5.078 Impact Factor

Quenching the fires: Pro-resolving mediators, air pollution, and smoking.

Pharmacol Ther 2019 Feb 10. Epub 2019 Feb 10.

Division of Pulmonary and Critical Care Medicine, University of Rochester School of Medicine and Dentistry Rochester, NY 14642, United States; Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, United States; Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, United States. Electronic address:

Exposure to air pollution and other environmental inhalation hazards, such as occupational exposures to dusts and fumes, aeroallergens, and tobacco smoke, is a significant cause of chronic lung inflammation leading to respiratory disease. It is now recognized that resolution of inflammation is an active process controlled by a novel family of small lipid mediators termed "specialized pro-resolving mediators" or SPMs, derived mainly from dietary omega-3 polyunsaturated fatty acids. Chronic inflammation results from an imbalance between pro-inflammatory and pro-resolution pathways. Read More

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http://dx.doi.org/10.1016/j.pharmthera.2019.02.001DOI Listing
February 2019

Lung Function Decline after 24 Weeks of Moxa Smoke Exposure in Rats.

Evid Based Complement Alternat Med 2019 10;2019:9236742. Epub 2019 Jan 10.

Beijing University of Chinese Medicine, Beijing, China.

Objective: Moxibustion is a complementary therapy that has been used for thousands of years. Burning moxa produces smoke and inhalable particulates. Recent research has indicated that smoke inhalation is associated with negative lung effects. Read More

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http://dx.doi.org/10.1155/2019/9236742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348917PMC
January 2019

Apoptotic effects of cigarette smoke extracts on mouse embryonic stem cells via oxidative stress.

Environ Toxicol 2019 Feb 11. Epub 2019 Feb 11.

Laboratory of Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea.

Previous studies have reported that cigarette smoke and cigarette smoke extract (CSE) have negative effects on embryonic development. However, no studies have investigated the mechanism through which CSE affects the cellular signaling pathway leading to apoptosis and oxidative stress in embryonic cells, or how the two pathways are cross-linked. Thus, we studied the effects of CSE on apoptosis and oxidative stress in mouse embryonic stem cells (mESCs). Read More

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http://dx.doi.org/10.1002/tox.22735DOI Listing
February 2019

Changes in behavioral and neuronal parameters by alcohol, cigarette, or their combined use in rats.

Behav Pharmacol 2019 Feb 4. Epub 2019 Feb 4.

Department of Pharmacology, Postgraduate Program in Pharmacology and Therapeutics.

Few studies have explored the effects of the combined use of alcohol and cigarette in humans, despite its prevalence. Here we evaluated the effect of isolated and combined use on behaviors and neuronal parameters in rats. Male adult rats were divided into alcohol (AL, 2 g/kg, by oral gavage), cigarette smoke (TB, six cigarettes, by inhalation), combined use (ALTB), or control (CT, water by oral gavage and environmental air) groups, treated twice a day (09. Read More

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http://Insights.ovid.com/crossref?an=00008877-900000000-9925
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http://dx.doi.org/10.1097/FBP.0000000000000476DOI Listing
February 2019
2 Reads

Bufei Jianpi Granules Reduce Quadriceps Muscular Cell Apoptosis by Improving Mitochondrial Function in Rats with Chronic Obstructive Pulmonary Disease.

Evid Based Complement Alternat Med 2019 6;2019:1216305. Epub 2019 Jan 6.

Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, China.

Background: Cell apoptosis is an important mechanism underlying skeletal muscle dysfunction in chronic obstructive pulmonary disease (COPD) patients, and mitochondrial dysfunction is recognized as a central aspect contributing to skeletal muscle deterioration. Bufei Jianpi granules have been confirmed effective for improving motor function in COPD patients, but the specific mechanism for this improved function remains unknown. This study explored the mechanisms by which Bufei Jianpi granules improve cell apoptosis and mitochondrial dysfunction in COPD. Read More

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http://dx.doi.org/10.1155/2019/1216305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339712PMC
January 2019

An Update of Current Cannabis-Based Pharmaceuticals in Pain Medicine.

Pain Ther 2019 Feb 5. Epub 2019 Feb 5.

Valley Anesthesiology and Pain Consultants, Phoenix, AZ, USA.

Cannabis users have long reported therapeutic properties of the plant for a variety of conditions, some of which include nausea, emesis, seizures, cancer, neurogenic diseases and pain control. Research has elucidated many cannabinoid pharmacodynamic and pharmacokinetic properties, expanding the potential use of cannabinoids as a medical therapy. Due to the inconsistent delivery and control of the active components involved with smoking, pharmaceutical companies are investigating and prioritizing routes other than smoke inhalation for therapeutic use of cannabinoids. Read More

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http://dx.doi.org/10.1007/s40122-019-0114-4DOI Listing
February 2019
2 Reads

Protective Features of Autophagy in Pulmonary Infection and Inflammatory Diseases.

Cells 2019 Feb 3;8(2). Epub 2019 Feb 3.

Department of Biomedical Sciences, University of North Dakota, Grand Forks, ND 58203, USA.

Autophagy is a highly conserved catabolic process involving autolysosomal degradation of cellular components, including protein aggregates, damaged organelles (such as mitochondria, endoplasmic reticulum, and others), as well as various pathogens. Thus, the autophagy pathway represents a major adaptive response for the maintenance of cellular and tissue homeostasis in response to numerous cellular stressors. A growing body of evidence suggests that autophagy is closely associated with diverse human diseases. Read More

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http://dx.doi.org/10.3390/cells8020123DOI Listing
February 2019
2 Reads

Neoantigens in Chronic Obstructive Pulmonary Disease and Lung Cancer: A Point of View.

Proteomics Clin Appl 2019 Jan 31:e1800093. Epub 2019 Jan 31.

Department of Neurology, Erasmus MC, Rotterdam, 3015 GE, Netherlands.

The goal of this manuscript is to explore the role of clinical proteomics for detecting mutations in chronic obstructive pulmonary disease (COPD) and lung cancer by mass spectrometry-based technology. COPD and lung cancer caused by smoke inhalation are most likely linked by challenging the immune system via partly shared pathways. Genome-wide association studies have identified several single nucleotide polymorphisms which predispose an increased susceptibility to COPD and lung cancer. Read More

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http://doi.wiley.com/10.1002/prca.201800093
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http://dx.doi.org/10.1002/prca.201800093DOI Listing
January 2019
3 Reads

The Oxidative Potential of Personal and Household PM in a Rural Setting in Southwestern China.

Environ Sci Technol 2019 Jan 30. Epub 2019 Jan 30.

The chemical constituents of fine particulate matter (PM2.5) vary by source and capacity to participate in redox reactions in the body, which produce cytotoxic reactive oxygen species (ROS). Knowledge of the sources and components of PM2. Read More

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http://pubs.acs.org/doi/10.1021/acs.est.8b05120
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http://dx.doi.org/10.1021/acs.est.8b05120DOI Listing
January 2019
3 Reads

Cadmium pigments in consumer products and their health risks.

Authors:
Andrew Turner

Sci Total Environ 2019 Mar 10;657:1409-1418. Epub 2018 Dec 10.

School of Geography, Earth and Environmental Sciences, Plymouth University, Drake Circus, Plymouth PL4 8AA, UK. Electronic address:

Cadmium is a toxic heavy metal that has been increasingly regulated over the past few decades. The main exposure routes for the general public are the consumption of certain foods and the inhalation of cigarette smoke. However, additional exposure may occur through the current and historical use of the metal in consumer products. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.12.096DOI Listing

Eucalyptol promotes lung repair in mice following cigarette smoke-induced emphysema.

Phytomedicine 2018 Aug 8;55:70-79. Epub 2018 Aug 8.

Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Brazil. Electronic address:

Background: Eucalyptol is a monoterpenoid oil present in many plants, principally the Eucalyptus species, and has been reported to have anti-inflammatory and antioxidative effects.

Hypothesis/purpose: Since the potential effect of eucalyptol on mouse lung repair has not yet been studied, and considering that chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide, the aim of this study was to investigate eucalyptol treatment in emphysematous mice.

Study Design: Male mice (C57BL/6) were divided into the following groups: control (sham-exposed), cigarette smoke (CS) (mice exposed to 12 cigarettes a day for 60 days), CS + 1 mg/ml (CS mice treated with 1 mg/ml eucalyptol for 60 days), and CS + 10 mg/ml (CS mice treated with 10 mg/ml eucalyptol for 60 days). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09447113183027
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http://dx.doi.org/10.1016/j.phymed.2018.08.012DOI Listing
August 2018
3 Reads

Fate of the inhaled smoke particles from fire scenes in the nasal airway of a realistic firefighter: A simulation study.

J Occup Environ Hyg 2019 Jan 22:1-13. Epub 2019 Jan 22.

b School of Engineering - Mechanical and Automotive , RMIT University , Bundoora , Victoria , Australia.

Understanding the inhalation, transport and deposition of smoke particles during fire missions are important to evaluating the health risks for firefighters. In this study, measurements from Underwriters Laboratories' large-scale fire experiments on smoke particle size distribution and concentration in three residential fire scenes were incorporated into models to investigate the fate of inhaled toxic ultrafine particulates in a realistic firefighter nasal cavity model. Deposition equations were developed, and the actual particle dosimetry (in mass, number and surface area) was evaluated. Read More

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http://dx.doi.org/10.1080/15459624.2019.1572900DOI Listing
January 2019
2 Reads

Particulate Matter Emissions of Four Different Cigarette Types of One Popular Brand: Influence of Tobacco Strength and Additives.

Int J Environ Res Public Health 2019 Jan 17;16(2). Epub 2019 Jan 17.

Institute of Occupational, Social and Environmental Medicine, Goethe University Frankfurt, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany.

The inhalation of particulate matter (PM) in second-hand smoke (SHS) is hazardous to health of smokers and non-smokers. Tobacco strength (amount of tar, nicotine, and carbon monoxide) and different additives might have an effect on the amount of PM. This study aimed to investigate the influence of tobacco strength or additives on PM. Read More

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http://dx.doi.org/10.3390/ijerph16020263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352107PMC
January 2019

Inhaled carbon monoxide increases vasodilation in the microvascular circulation.

Microvasc Res 2019 May 15;123:92-98. Epub 2019 Jan 15.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada; Department of Obstetrics & Gynaecology, Queen's University, Kingston, Ontario, Canada. Electronic address:

Preeclampsia (PE) is characterized by systemic maternal endothelial dysfunction. Changes in endothelial reactivity have been reported before the onset of clinical signs of PE, and continuing into the post-partum period. Women who smoke during pregnancy have a 33% reduced risk of developing PE. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00262862183021
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http://dx.doi.org/10.1016/j.mvr.2019.01.004DOI Listing
May 2019
11 Reads

A preliminary investigation of lung availability of cannabinoids by smoking marijuana or dabbing BHO and decarboxylation rate of THC- and CBD-acids.

Forensic Sci Int 2019 Feb 6;295:207-212. Epub 2019 Jan 6.

Landeskriminalamt Nordrhein-Westfalen, KTI - Teildezernat 51.2 Betäubungsmittel, Völklinger Strasse 49, 40221, Düsseldorf, Germany.

Highly potent cannabis concentrates obtained by butane or by supercritical carbon dioxide-extraction are gaining popularity. These extracts called butane hash oil (BHO) with Δ-tetrahydrocannabinolic acid A (THCA) contents above 60% are consumed by flash vaporization on a glowing titanium nail, followed by inhalation of the resulting vapor through a water pipe in a single puff - a technique referred to as "dabbing". We herein investigated the decarboxylation rate of THCA during artificial smoking of cannabis plant material and simulated dabbing, and the lung availability of Δ-tetrahydrocannabinol (THC) which we define as the recovery of THC in the smoke and vapor condensates. Read More

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http://dx.doi.org/10.1016/j.forsciint.2018.12.021DOI Listing
February 2019
1 Read

Short-term regulation of the hepatic activities of cytochrome P450 and glutathione S-transferase by nose-only cigarette smoke exposure in mice.

Food Chem Toxicol 2019 Jan 3;125:182-189. Epub 2019 Jan 3.

College of Pharmacy, Chungnam National University, Republic of Korea. Electronic address:

The present study aimed to determine the effects of cigarette smoke on the regulation of hepatic cytochrome P450 (CYP) and glutathione S-transferase (GST) enzymes in male BALB/c mice exposed to nose-only cigarette smoke for 4 days. There were no significant increases in serum liver injury markers (alanine aminotransferase and aspartate aminotransferase) or oxidative stress (total antioxidant capacity, malondialdehyde, and glutathione disulfide/reduced glutathione) following cigarette smoke exposure, but malondialdehyde was elevated in the bronchoalveolar lavage fluid of smoke-exposed mice. Additionally, the hepatic microsomal protein levels of Cyp1a and Cyp2b, and the activities of ethoxyresorufin O-deethylase, pentoxyresorufin O-depenylase, and chlorzoxazone 6-hydrxylase, were elevated in smoke-exposed mice. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915183090
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http://dx.doi.org/10.1016/j.fct.2018.12.035DOI Listing
January 2019
7 Reads

Claudins, VEGF, Nrf2, Keap1, and Nonspecific Airway Hyper-Reactivity Are Increased in Mice Co-Exposed to Allergen and Acrolein.

Chem Res Toxicol 2019 Jan 4. Epub 2019 Jan 4.

Division of Allergy and Respiratory Medicine, Department of Internal Medicine , Soonchunhyang University Bucheon Hospital , Bucheon , Gyeonggi-do Republic of Korea 14584.

Acrolein, an α/β-unsaturated aldehyde, is volatile at room temperature. It is a respiratory irritant found in environmental tobacco smoke, which can be generated during cooking or endogenously at sites of injury. An acute high concentration of uncontrolled irritant exposure can lead to an asthma-like syndrome known as reactive airways dysfunction syndrome (RADS). Read More

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http://dx.doi.org/10.1021/acs.chemrestox.8b00239DOI Listing
January 2019
5 Reads

Cinnamaldehyde in Flavored E-Cigarette Liquids Temporarily Suppresses Bronchial Epithelial Cell Ciliary Motility by Dysregulation of Mitochondrial Function.

Am J Physiol Lung Cell Mol Physiol 2019 Jan 3. Epub 2019 Jan 3.

Center for Environmental Medicine and Lung Biology, The The University of North Carolina at Chapel Hill, United States.

Aldehydes in cigarette smoke (CS) impair mitochondrial function and reduce ciliary beat frequency (CBF), leading to diminished mucociliary clearance (MCC). However, the effects of aldehyde e-cigarette flavorings on CBF is unknown. The purpose of this study was to investigate whether cinnamaldehyde, a flavoring agent commonly used in e-cigarettes, disrupts mitochondrial function and impairs CBF on well-differentiated human bronchial epithelial (hBE) cells. Read More

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http://dx.doi.org/10.1152/ajplung.00304.2018DOI Listing
January 2019
1 Read

A Neutralizing Aptamer to TGFBR2 and miR-145 Antagonism Rescue Cigarette Smoke- and TGF-β-Mediated CFTR Expression.

Mol Ther 2019 Feb 6;27(2):442-455. Epub 2018 Dec 6.

Department of Immunology and Nanomedicine, Institute of Neuroimmune Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA. Electronic address:

Transforming growth factor β (TGF-β), signaling induced by cigarette smoke (CS), plays an important role in the progression of airway diseases, like chronic bronchitis associated with chronic obstructive pulmonary disease (COPD), and in smokers. Chronic bronchitis is characterized by reduced mucociliary clearance (MCC). Cystic fibrosis transmembrane conductance regulator (CFTR) plays an important role in normal MCC. Read More

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http://dx.doi.org/10.1016/j.ymthe.2018.11.017DOI Listing
February 2019
3 Reads

Evaluation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) mutagenicity using in vitro and in vivo Pig-a assays.

Mutat Res 2019 Jan 29;837:65-72. Epub 2018 Oct 29.

U.S. Food and Drug Administration, Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, USA. Electronic address:

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a genotoxic carcinogen found in tobacco and tobacco smoke. Several in vitro and in vivo assays have been used for evaluating the genotoxicity of tobacco smoke and tobacco smoke constituents like NNK, yet it is not clear which in vitro assays are most appropriate for extrapolating the in vitro responses of these test agents to animal models and humans. The Pig-a gene mutation assay can be performed in vitro, in laboratory animals, and in humans, a potential benefit in estimating in vivo responses from in vitro data. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2018.10.007DOI Listing
January 2019
1 Read

Nodular rheumatoid arthritis (RA): A distinct disease subtype, initiated by cadmium inhalation inducing pulmonary nodule formation and subsequent RA-associated autoantibody generation.

Med Hypotheses 2019 Jan 22;122:48-55. Epub 2018 Oct 22.

Department of Rheumatology, Royal Cornwall Hospital Trust, Truro, UK. Electronic address:

Nodular rheumatoid arthritis (RA) patients have raised rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA) levels, and are more likely to smoke than RA patients without nodules. Subcutaneous and pulmonary rheumatoid nodules (granulomas) frequently co-exist. Pulmonary rheumatoid nodules develop prior to RA development and have the immunological machinery to generate RF and ACPAs. Read More

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http://dx.doi.org/10.1016/j.mehy.2018.10.021DOI Listing
January 2019
4 Reads

Whole cigarette smoke condensates induce ferroptosis in human bronchial epithelial cells.

Toxicol Lett 2019 Mar 21;303:55-66. Epub 2018 Dec 21.

Seoul Center, Korea Basic Science Institute, Seoul, Republic of Korea.

Cigarette smoke is responsible for many fatal pulmonary diseases, however, the toxic mechanism is still unclear. In this study, we first confirmed that whole cigarette smoke condensates (WCSC) contain hydrophilic elements, lipophilic and gaseous components. Then, we treated BEAS-2B cells, a normal human bronchial epithelial cell line, at dosages of 0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03784274183175
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http://dx.doi.org/10.1016/j.toxlet.2018.12.007DOI Listing
March 2019
9 Reads

Current clinical management of smoke inhalation injuries: a reality check.

Eur Respir J 2018 Dec 6;52(6). Epub 2018 Dec 6.

1st Respiratory Medicine Dept, National and Kapodistrian University of Athens, Medical School, Athens, Greece.

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http://dx.doi.org/10.1183/13993003.02163-2018DOI Listing
December 2018

Inhalation lung injury induced by smoke bombs in children: CT manifestations, dynamic evolution features and quantitative analysis.

J Thorac Dis 2018 Oct;10(10):5860-5869

Department of Radiology, Gansu Provincial Hospital, Lanzhou 713000, China.

Background: This retrospective study aimed to investigate the computed tomography (CT) manifestations, short-term dynamic evolution features and quantitative lung CT analysis of inhalation lung injury induced by smoke bomb flare.

Methods: Eleven pediatric patients (aged 11 to 13) who inhaled the smoke of smoke bombs underwent several low-dose chest CT scans. The image characteristics and their dynamic changes were observed and quantitative CT values were analyzed. Read More

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http://dx.doi.org/10.21037/jtd.2018.09.84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236165PMC
October 2018
1 Read

Novel pharmacotherapy for burn wounds: what are the advancements.

Expert Opin Pharmacother 2019 Feb 5;20(3):305-321. Epub 2018 Dec 5.

a Wellman Center for Photomedicine , Massachusetts General Hospital , Boston , MA , USA.

Introduction: The prognosis for severe burns has improved significantly over the past 50 years. Meanwhile, burns have become an affliction mainly affecting the less well-developed regions of the world. Early excision and skin grafting has led to major improvements in therapeutic outcomes. Read More

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https://www.tandfonline.com/doi/full/10.1080/14656566.2018.1
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http://dx.doi.org/10.1080/14656566.2018.1551880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364296PMC
February 2019
5 Reads

Modulation of Peroxynitrite Reduces Norepinephrine Requirements in Ovine MRSA Septic Shock.

Shock 2018 Nov 28. Epub 2018 Nov 28.

Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas.

Vascular hypo-responsiveness to vasopressors during septic shock is a challenging problem. This study is to test the hypothesis that reactive nitrogen species (RNS), such as peroxynitrite, are major contributing factors to vascular hypo-responsiveness in septic shock. We hypothesized that adjunct therapy with peroxynitrite decomposition catalyst (PDC) would reduce norepinephrine requirements in sepsis resuscitation. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001297DOI Listing
November 2018
7 Reads

Silicosis and lung cancer: current perspectives.

Lung Cancer (Auckl) 2018 26;9:91-101. Epub 2018 Oct 26.

Cancer and Inflammation Program, National Cancer Institute, Frederick, MD 21702, USA,

"Silica" refers to crystalline particles formed by the combination of silicon with oxygen. Inhalation of silica particles promotes the development of pulmonary fibrosis that over prolonged periods increases the risk of lung cancer. The International Agency for Research on Cancer (IARC) classified crystalline silica as a human carcinogen in 1997. Read More

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http://dx.doi.org/10.2147/LCTT.S156376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207090PMC
October 2018
1 Read

Cigarette smoke extract may induce lysosomal storage disease-like adverse health effects.

J Appl Toxicol 2018 Nov 28. Epub 2018 Nov 28.

Jeonbuk Department of Inhalation Research, Korea Institute of Toxicology, Jeongeup, Jellobuk-do, Republic of Korea.

Cigarette smoke is known to be associated with the incidence of a variety of pulmonary diseases, and alveolar macrophages are a key player in the defense mechanism against inhalable toxicants. Herein, we have found that a hydrophilic fraction in smoke extracts from 3R4F reference cigarettes (CSE) contains high concentrations of volatile substances compared to cigarette smoke condensate (amphoteric fraction). We also identified the toxic mechanism of CSE using MH-S, a mouse alveolar macrophage cell line. Read More

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http://dx.doi.org/10.1002/jat.3744DOI Listing
November 2018
9 Reads

Macrophage Exposure to Polycyclic Aromatic Hydrocarbons From Wood Smoke Reduces the Ability to Control Growth of .

Front Med (Lausanne) 2018 13;5:309. Epub 2018 Nov 13.

Medica Sur, Clinic and Foundation, Mexico City, Mexico.

Use of solid fuels for cooking or home heating has been related to various diseases of the respiratory tract. Woodsmoke contains a mixture of carcinogenic polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds. Inhalation of these materials induces local and systemic changes in the immune system which may impair critical cell defense mechanisms; however, few studies have investigated the early effects that PAH exposures have on immune cells as macrophages. Read More

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http://dx.doi.org/10.3389/fmed.2018.00309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243050PMC
November 2018
1 Read

Point-of-care endoscopic optical coherence tomography detects changes in mucosal thickness in ARDS due to smoke inhalation and burns.

Burns 2018 Nov 24. Epub 2018 Nov 24.

The Geneva Foundation, Tacoma WA, United States; United States Army Institute of Surgical Research, JBSA Ft. Sam Houston, TX, United States.

Background: The prevalence of acute respiratory distress syndrome (ARDS) in mechanically ventilated burn patients is 33%, with mortality varying from 11-46% depending on ARDS severity. Despite the new Berlin definition for ARDS, prompt bedside diagnosis is lacking. We developed and tested a bedside technique of fiberoptic-bronchoscopy-based optical coherence tomography (OCT) measurement of airway mucosal thickness (MT) for diagnosis of ARDS following smoke inhalation injury (SII) and burns. Read More

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http://dx.doi.org/10.1016/j.burns.2018.10.014DOI Listing
November 2018
8 Reads
1.836 Impact Factor

ECMO improves survival following cardiogenic shock due to carbon monoxide poisoning - an experimental porcine model.

Scand J Trauma Resusc Emerg Med 2018 Nov 22;26(1):103. Epub 2018 Nov 22.

Department of Cardiothoracic Surgery, Aalborg University Hospital, Hobrovej 18-22, 9000, Aalborg, Denmark.

Background: Severe intoxication with carbon monoxide (CO) is extremely lethal and causes numerous deaths due to cardiac or respiratory failure. Conventional intensive treatment may not be sufficient. The aim of this study was to investigate the treatment effect of extracorporeal veno-arterial extracorporeal membrane oxygenation (ECMO) following severe CO poisoning in an experimental porcine model. Read More

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http://dx.doi.org/10.1186/s13049-018-0570-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251161PMC
November 2018
1 Read

Influence of machine-based puffing parameters on aerosol and smoke emissions from next generation nicotine inhalation products.

Regul Toxicol Pharmacol 2019 Feb 13;101:156-165. Epub 2018 Nov 13.

British American Tobacco, Regents Park Road, Southampton, SO15 8TL, UK.

There is increasing diversity of nicotine inhalation products worldwide. Next Generation Products (NGP) such as e-cigarettes, have gained mass popularity, and there is increasing use of electrical and carbon-based Tobacco-Heating Products (e-THP and c-THP respectively). Recently, emission levels from these products have been compared to conventional cigarettes (CC); however, few formal laboratory testing standards exist, and inconsistent puffing parameters have been used. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02732300183029
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http://dx.doi.org/10.1016/j.yrtph.2018.11.006DOI Listing
February 2019
13 Reads

[National experts consensus on clinical diagnosis and treatment of inhalation injury (2018 version)].

Zhonghua Shao Shang Za Zhi 2018 Nov;34(11):E004

400038 Chongqing, State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, the First Affiliated Hospital of Army Medical University (the Third Military Medical University).

Inhalation injury is caused by inhalation of heat, toxic or irritating gases which lead to respiratory and pulmonary parenchyma damage. At present, the clinical understanding about it is still limited and lack of effective diagnosis and treatment standard. Based on the experience of diagnosis and treatment of domestic inhalation injury, combined with reports of international researches, criteria (expert consensus) for inhalation injury were systematically discussed from pathological and pathophysiological changes, clinical diagnosis and evaluation, and clinical treatment, which provides reference for clinical diagnosis and treatment of patients inflicted with inhalation injury. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1009-2587.2018.11.E004DOI Listing
November 2018
13 Reads

Emerging Concepts and Therapies for Mucoobstructive Lung Disease.

Ann Am Thorac Soc 2018 Nov;15(Supplement_3):S216-S226

4 Marsico Lung Institute, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina.

A spectrum of intrapulmonary airway diseases, for example, cigarette smoke-induced bronchitis, cystic fibrosis, primary ciliary dyskinesia, and non-cystic fibrosis bronchiectasis, can be categorized as "mucoobstructive" airway diseases. A common theme for these diseases appears to be the failure to properly regulate mucus concentration, producing mucus hyperconcentration that slows mucus transport and, importantly, generates plaque/plug adhesion to airway surfaces. These mucus plaques/plugs generate long diffusion distances for oxygen, producing hypoxic niches within adherent airway mucus and subjacent epithelia. Read More

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https://www.atsjournals.org/doi/10.1513/AnnalsATS.201806-368
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http://dx.doi.org/10.1513/AnnalsATS.201806-368AWDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322026PMC
November 2018
11 Reads

The effects of particle density in moxa smoke on the ultrastructure of knee cartilage and expressions of TNF-α, IL-1b, BAX, and Bcl-2 mRNA in a rat model for osteoarthritis.

J Cell Biochem 2018 Nov 14. Epub 2018 Nov 14.

Department of Knee Joint, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Luoyang, Henan, China.

Background: The effectiveness of smokeless moxa and other means to reduce exposure are extensively investigated with regards to the health consequences of inhalation of moxa smoke, and clinical studies indicate that classical moxibustion is superior to smokeless moxa. This study aims to quantify the effects of particle density in moxa smoke on the clinical outcome with an established model, demonstrated to be effective for classical moxibustion.

Objectives: The purpose of this study is to explore the effects of particle density in moxa smoke on the ultrastructure of knee cartilage and expression of cytokine, tissue necrosing factor-alpha (TNF-α), interleukin 1 beta (IL-1b), apoptosis regulator, B-cell lymphoma-2 (Bcl-2), and BAX in a rat model for inflammatory joint disease. Read More

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http://doi.wiley.com/10.1002/jcb.27952
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http://dx.doi.org/10.1002/jcb.27952DOI Listing
November 2018
11 Reads

Serum zinc level is associated with liver dysfunction caused by white smoke inhalation.

Authors:
Fei Xie Lixin Xie

Gastroenterol Rep (Oxf) 2018 Nov 7;6(4):304-307. Epub 2018 Mar 7.

Department of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China.

Background: White smoke bomb exposure in the military setting could result in organ injuries, which is uncommon and has been rarely described in previous studies. The aim of this study is to observe whether serum zinc levels are associated with liver function after white smoke inhalation.

Methods: Fifteen patients with white smoke exposure were the subjects in this study. Read More

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http://dx.doi.org/10.1093/gastro/goy008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225814PMC
November 2018
1 Read

Exposure to cigarette smoke via respiratory system may induce abnormal alterations of reproductive organs in female diabetic rats.

Environ Toxicol 2019 Jan 12;34(1):13-21. Epub 2018 Nov 12.

Laboratory of Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea.

Cigarette smoke (CS) has harmful effects on human fertility, reproduction, and development as well as on patients suffering from metabolic diseases such as diabetes than on healthy individuals. This study was conducted to investigate the relationship between CS exposure and histological alterations of reproductive organs in female diabetic rats. We evaluated the histology of uteruses and ovaries obtained from female rats exposed to smoke from standard cigarettes for 4 weeks (28 hours a week). Read More

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http://dx.doi.org/10.1002/tox.22652DOI Listing
January 2019
1 Read

Factors affecting smoke and crystalline silica exposure among wildland firefighters.

J Occup Environ Hyg 2018 Nov 8:1-36. Epub 2018 Nov 8.

b USDA Forest Service, Technology & Development , Boise , Idaho , USA.

Smoke exposure data among U.S. wildland firefighters for carbon monoxide, respirable particulate and respirable crystalline silica are presented from a field surveillance program between 2009 and 2012. Read More

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http://dx.doi.org/10.1080/15459624.2018.1540873DOI Listing
November 2018
1 Read
1.170 Impact Factor

Are electronic cigarettes a healthier alternative to conventional tobacco smoking?

Eur Arch Otorhinolaryngol 2019 Jan 3;276(1):17-25. Epub 2018 Nov 3.

Schleswig-Holstein University Hospital, Lübeck Campus, ENT Clinic, Lübeck, Germany.

Electronic cigarettes (EC) with and without nicotine are used by more and more consumers within the last decade. The long-term risks of vapor inhalation are unknown. This study should describe the state of the art of knowledge with respect to the following four items: (1) ingredients of the vapor and their potential risks, the influence of EC on smoking of combustible tobacco to (2) adults and (3) the youth, and (4) the side effects of passive vaping. Read More

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http://link.springer.com/10.1007/s00405-018-5185-z
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http://dx.doi.org/10.1007/s00405-018-5185-zDOI Listing
January 2019
10 Reads

Heme scavenging reduces pulmonary endoplasmic reticulum stress, fibrosis, and emphysema.

JCI Insight 2018 Nov 2;3(21). Epub 2018 Nov 2.

Department of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine.

Pulmonary fibrosis and emphysema are irreversible chronic events after inhalation injury. However, the mechanism(s) involved in their development remain poorly understood. Higher levels of plasma and lung heme have been recorded in acute lung injury associated with several insults. Read More

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https://insight.jci.org/articles/view/120694
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http://dx.doi.org/10.1172/jci.insight.120694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238745PMC
November 2018
3 Reads

Utilizing Ion Mobility to Identify Isobaric Post-Translational Modifications: Resolving Acrolein and Propionyl Lysine Adducts by TIMS Mass Spectrometry.

Int J Ion Mobil Spectrom 2018 Sep 9;21(3):65-69. Epub 2018 Aug 9.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States.

Protein post-translational modifications provide critical proteomic details towards elucidating mechanisms of altered protein function due to toxic exposure, altered metabolism, or disease pathogenesis. Lysine propionylation is a recently described modification that occurs due to metabolic alterations in propionyl-CoA metabolism and sirtuin depropionylase activity. Acrolein is a toxic aldehyde generated through exogenous and endogenous pathways, such as industrial exposure, cigarette smoke inhalation, and non-enzymatic lipid peroxidation. Read More

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http://dx.doi.org/10.1007/s12127-018-0237-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200409PMC
September 2018

Inhaled calcium salts inhibit tobacco smoke-induced inflammation by modulating expression of chemokines and cytokines.

Pulm Pharmacol Ther 2018 Dec 22;53:86-99. Epub 2018 Oct 22.

Pulmatrix Inc., 99 Hayden Ave, Suite 390, Lexington, MA 02421, USA. Electronic address:

Tobacco smoke-induced lung inflammation in patients with chronic obstructive pulmonary disease (COPD) worsens with disease progression and acute exacerbations caused by respiratory infections. Chronic therapies to manage COPD center on bronchodilators to improve lung function and inhaled corticosteroids (ICS) to help reduce the risk of exacerbations. Novel therapies are needed that reduce the underlying inflammation associated with COPD and the inflammation resulting from respiratory infections that worsen disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10945539183009
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http://dx.doi.org/10.1016/j.pupt.2018.10.004DOI Listing
December 2018
13 Reads

Selective Uptake of Third-Hand Tobacco Smoke Components to Inorganic and Organic Aerosol Particles.

Environ Sci Technol 2018 Nov 31;52(22):13195-13201. Epub 2018 Oct 31.

Department of Chemistry , University of Toronto ; 80 St. George Street , Toronto , ON M5S 3H6 , Canada.

Third-hand smoke (THS) is an emerging route of exposure to tobacco smoke in the indoor environment. Few studies have investigated the chemical behavior of THS, although initial findings suggest that semivolatile components of THS can partition to indoor aerosol. By exposing single-component particles to THS in an environmental chamber, this study demonstrates a pronounced dependence of THS uptake on aerosol composition. Read More

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http://dx.doi.org/10.1021/acs.est.8b03880DOI Listing
November 2018
3 Reads

Resveratrol attenuates oxidative stress during experimental periodontitis in rats exposed to cigarette smoke inhalation.

J Periodontal Res 2018 Oct 22. Epub 2018 Oct 22.

Dental Research Division, School of Dentistry, Paulista University, São Paulo, São Paulo, Brazil.

Objectives: This study aimed at investigating the effect of the systemic administration of resveratrol (RESV) on oxidative stress during experimental periodontitis in rats subjected to cigarette smoke inhalation.

Material And Methods: Experimental periodontitis (EP) was induced in 26 male Wistar rats by the insertion of a ligature around one of the first mandibular and maxillary molars. The animals were assigned randomly to the following groups: cigarette smoke inhalation (CSI; 3 times/d, 8 minutes/d) + resveratrol (10 mg/Kg), that is, SMK + RESV (n = 13) and cigarette smoke inhalation + placebo, that is, SMK + PLAC (n = 13). Read More

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http://dx.doi.org/10.1111/jre.12622DOI Listing
October 2018
2 Reads

Triangulating abuse liability assessment for flavoured cigar products using physiological, behavioural economic and subjective assessments: a within-subjects clinical laboratory protocol.

BMJ Open 2018 Oct 10;8(10):e023850. Epub 2018 Oct 10.

Department of Psychology, Virginia Commonwealth University, Richmond, Virginia, USA.

Introduction: In the USA, Food and Drug Administration regulations prohibit the sale of flavoured cigarettes, with menthol being the exception. However, the manufacture, advertisement and sale of flavoured cigar products are permitted. Such flavourings influence positive perceptions of tobacco products and are linked to increased use. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02385
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http://dx.doi.org/10.1136/bmjopen-2018-023850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252773PMC
October 2018
2 Reads

Characteristics and outcome of burned children admitted to a pediatric intensive care unit.

Rev Bras Ter Intensiva 2018 Jul-Sept;30(3):333-337. Epub 2018 Oct 4.

Programa de Terapia Intensiva Pediátrica, Hospital da Criança Santo Antônio - Porto Alegre (RS), Brasil.

Objective: To analyze the characteristics and outcomes of children hospitalized for burns in a pediatric trauma intensive care unit for burn patients.

Methods: An observational study was conducted through the retrospective analysis of children (< 16 years) admitted to the pediatric trauma intensive care unit for burn victims between January 2013 and December 2015. Sociodemographic and clinical variables were analyzed including the causal agent, burned body surface, presence of inhalation injury, length of hospital stay and mortality. Read More

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http://www.gnresearch.org/doi/10.5935/0103-507X.20180045
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http://dx.doi.org/10.5935/0103-507x.20180045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180472PMC
December 2018
2 Reads