529 results match your criteria Small Cell Carcinoma of the Prostate


Urothelial carcinoma with villoglandular differentiation (UCVGD) with small cell neuroendocrine carcinoma of urinary bladder.

BMJ Case Rep 2019 Jan 18;12(1). Epub 2019 Jan 18.

Urology, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, Orissa, India.

Urothelial carcinoma with villoglandular differentiation (UCVGD) is a rare aggressive variant of urothelial carcinoma. It is usually associated with high-grade urothelial carcinoma or rarely adenocarcinoma. There is only one other previous report of UCVGD associated with small cell neuroendocrine carcinoma of urinary bladder. Read More

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http://dx.doi.org/10.1136/bcr-2018-228017DOI Listing
January 2019
3 Reads

Poorly Differentiated Small-Cell-Type Neuroendocrine Carcinoma of the Prostate: A Case Report and Literature Review.

Case Rep Oncol 2018 Sep-Dec;11(3):676-681. Epub 2018 Oct 31.

Department of Medicine, Bronx Lebanon Hospital Center, Bronx, New York, USA.

Neuroendocrine cells are widespread throughout the body and can give rise of neuroendocrine tumors due to abnormal growth of the chromaffin cells. Neuroendocrine tumors divide into many subtypes based on tumor grade (Ki-67 index and mitotic count) and differentiation. These tumors can be further divided into secretory and nonsecretory types based on the production of peptide hormone by tumor cells. Read More

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http://dx.doi.org/10.1159/000493255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243899PMC
October 2018
2 Reads

Asynchronous tumour quadruplicity: rectosigmoid adenocarcinoma, renal cell carcinoma, prostate adenocarcinoma and neuroendocrine small-cell lung cancer - a case report.

Rozhl Chir 2018 ;97(9):427-431

Introduction: Multiple tumors belong to rare cancers. Almost all malignancies may occur in combination, the most common combination being gastrointestinal cancer with respiratory or urogenital tract cancer and with breast cancer in females.

Case Report: In 1999, a 66-year-old patient was diagnosed with a rectosigmoid tumor histologically proven as adenocarcinoma. Read More

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January 2018
9 Reads

Lesson of the month 2: An unusual cause of depression in an older man: Cushing's syndrome resulting from metastatic small cell cancer of the prostate.

Clin Med (Lond) 2018 Oct;18(5):432-434

Royal Adelaide Hospital, Adelaide, Australia.

This article describes the case of an older patient whose main presenting problem was depression. A constellation of clinical and biochemical features led to a search for medical causes of his low mood, which uncovered ectopic adrenocorticotropic hormone (ACTH) secretion. Post-mortem examination showed that the source of ACTH was small cell neuroendocrine carcinoma of the prostate, and that the patient had died from the sequelae of profound immune suppression. Read More

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http://dx.doi.org/10.7861/clinmedicine.18-5-432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334104PMC
October 2018
3 Reads

DUSP1 is involved in the progression of small cell carcinoma of the prostate.

Saudi J Biol Sci 2018 Jul 18;25(5):858-862. Epub 2017 Oct 18.

The First Hospital of Shijiazhuang, Shijiangzhuang 050011, PR China.

Small cell carcinoma of the prostate (SCCP) is a rare and the most aggressive variant of prostate cancer. There is no effective cure or treatment for SCCP. Therefore, there is an urgent need for new therapy to improve the prognosis of patients with SCCP. Read More

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http://dx.doi.org/10.1016/j.sjbs.2017.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088105PMC
July 2018
9 Reads
0.741 Impact Factor

Pure small-cell carcinoma of the prostate presenting with increasing prostate-specific antigen levels: A case report and review of the literature.

Mol Clin Oncol 2018 Aug 4;9(2):197-200. Epub 2018 Jun 4.

Department of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China.

The incidence of prostatic cancer (PCa) has increased significantly, and the measurement of prostate-specific antigen (PSA) is an effective screening tool for its diagnosis. PCa includes a number of specific clinicopathological types, including squamous cell, urothelial, adenoid cystic and small-cell carcinoma, among which small-cell carcinoma of the prostate (SCCP) is extremely rare, accounting for <0.5% of all PCa cases. Read More

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http://dx.doi.org/10.3892/mco.2018.1644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083420PMC
August 2018
6 Reads

Regulation of monoamine oxidase A (MAO-A) expression, activity, and function in IL-13-stimulated monocytes and A549 lung carcinoma cells.

J Biol Chem 2018 09 18;293(36):14040-14064. Epub 2018 Jul 18.

From the Department of Biotechnology, National Institute of Technology-Durgapur, Mahatma Gandhi Avenue, Durgapur-713209, Burdwan, West Bengal, India,

Monoamine oxidase A (MAO-A) is a mitochondrial flavoenzyme implicated in the pathogenesis of atherosclerosis and inflammation and also in many neurological disorders. MAO-A also has been reported as a potential therapeutic target in prostate cancer. However, the regulatory mechanisms controlling cytokine-induced MAO-A expression in immune or cancer cells remain to be identified. Read More

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http://dx.doi.org/10.1074/jbc.RA118.002321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130935PMC
September 2018
3 Reads

Insulinoma-associated protein 1 is a novel sensitive and specific marker for small cell carcinoma of the prostate.

Hum Pathol 2018 Sep 6;79:151-159. Epub 2018 Jun 6.

Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 200127 Shanghai, China. Electronic address:

The correct diagnosis of small cell carcinoma (SCC) of the prostate is critical because of its aggressive behavior and poor prognosis. The histopathologic diagnosis could be challenging without neuroendocrine markers, which currently has limitations. Insulinoma-associated protein 1 (INSM1), a zinc-finger transcription factor, is considered to play an important role in the development of several neuroendocrine precursor cells. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.05.014DOI Listing
September 2018
7 Reads

Neuroendocrine Differentiation in Prostate Cancer: Emerging Biology, Models, and Therapies.

Cold Spring Harb Perspect Med 2019 Feb 1;9(2). Epub 2019 Feb 1.

Englander Institute for Precision Medicine, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, New York 10021.

Although a de novo clinical presentation of small cell neuroendocrine carcinoma of the prostate is rare, a subset of patients previously diagnosed with prostate adenocarcinoma may develop neuroendocrine features in later stages of castration-resistant prostate cancer (CRPC) progression as a result of treatment resistance. Despite sharing clinical, histologic, and some molecular features with other neuroendocrine carcinomas, including small cell lung cancer, castration-resistant neuroendocrine prostate cancer (CRPC-NE) is clonally derived from prostate adenocarcinoma. CRPC-NE therefore retains early prostate cancer genomic alterations and acquires new molecular changes making them resistant to traditional CRPC therapies. Read More

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http://dx.doi.org/10.1101/cshperspect.a030593DOI Listing
February 2019
2 Reads

Transplantable Animal Studies and Whole-Body Optical Imaging in Prostate Carcinoma.

Methods Mol Biol 2018 ;1786:81-102

Department of Urology, Leiden University Medical Center, Leiden, The Netherlands.

Current treatments of advanced prostate cancer only marginally increase overall survival and can be regarded as predominantly palliative. Hence, there is an urgent need for novel therapeutic strategies for the treatment of primary tumors and, more importantly perhaps, for the prevention of tumor progression and metastasis formation. Clinically relevant preclinical models are therefore urgently needed. Read More

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http://dx.doi.org/10.1007/978-1-4939-7845-8_5DOI Listing
February 2019
3 Reads

[Development of Ectopic Adrenocorticotropic Hormone Syndrome in a Patient with Prostate Cancer during Combined Androgen Blockade Therapy].

Hinyokika Kiyo 2018 Apr;64(4):175-179

The Department of Urology, Hyogo Prefectural Nishinomiya Hospital.

A 74-year old man presented to us with difficulty urinating. The laboratory examinations revealed an elevated prostate-specific antigen (PSA) level. A prostate biopsy revealed prostate adenocarcinoma. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_64_4_175DOI Listing
April 2018
3 Reads

Dual Paraneoplastic Endocrine Syndromes Heralding Onset of Extrapulmonary Small Cell Carcinoma: A Case Report and Narrative Review.

Front Endocrinol (Lausanne) 2018 18;9:170. Epub 2018 Apr 18.

Division of Endocrinology, Diabetes and Metabolism, Icahn School of Medicine at Mount Sinai, Mount Sinai St. Luke's and West Hospital Center, New York, NY, United States.

Objective: Extrapulmonary small cell carcinoma (EPSCC) is rare and frequent metastases at presentation can complicate efforts to identify a site of origin. In particular, SCC comprises <1% of prostate cancers and has been implicated in castration resistance.

Methods: Clinical, laboratory, imaging, and pathology data are presented. Read More

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http://dx.doi.org/10.3389/fendo.2018.00170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932342PMC
April 2018
7 Reads

Anaplastic Lymphoma Kinase Mutation ( F1174C) in Small Cell Carcinoma of the Prostate and Molecular Response to Alectinib.

Clin Cancer Res 2018 Jun 20;24(12):2732-2739. Epub 2018 Mar 20.

The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Small cell carcinoma of the prostate (SCCP) is an aggressive disease that can arise or by transdifferentiation from prostate adenocarcinoma. Alterations in anaplastic lymphoma kinase () gene are involved in neuroblastoma, lung cancer, and other malignancies, but its role in SCCP has not been documented. We describe a patient with refractory SCCP with F1174C-activating mutation who obtained clinical benefit from treatment with ALK inhibitor. Read More

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-0332DOI Listing
June 2018
13 Reads
1 Citation
8.722 Impact Factor

Small Cell Carcinoma of Prostate: A Case Report of a Patient With Concomitant Transitional Cell Cancer of the Bladder.

J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618760644. Epub 2018 Mar 5.

Department of Hematology/Oncology, Joan C. Edwards School of Medicine, Marshall University, USA.

Small cell carcinomas (SCCs) are aggressive neoplasms commonly associated with a pulmonary origin. However, albeit rare, extrapulmonary SCC can occur in a variety of sites with an incidence in North America approximated to be 0.1% to 0. Read More

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http://dx.doi.org/10.1177/2324709618760644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844437PMC
March 2018
7 Reads

[Four Cases of Bacteremia Caused by Helicobacter cinaedi in the Urological Ward at About the Same Time].

Hinyokika Kiyo 2017 Nov;63(11):461-463

The Department of Urology, Sapporo Medical University School of Medicine.

Here we report the outbreak of bacteremia caused by Helicobacter cinaedi (H. cinaedi) in the urology ward. Case 1 was a man in his seventies with prostate cancer. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_63_11_461DOI Listing
November 2017
25 Reads

Coatomer subunit beta 2 (COPB2), identified by label-free quantitative proteomics, regulates cell proliferation and apoptosis in human prostate carcinoma cells.

Biochem Biophys Res Commun 2018 01 10;495(1):473-480. Epub 2017 Nov 10.

Department of Urology, Huashan Hospital, Fudan University, 12 Central Urumqi Rd, Shanghai 200040, PR China. Electronic address:

Label-free quantitative proteomics has broad applications in the identification of differentially expressed proteins. Here, we applied this method to identify differentially expressed proteins (such as coatomer subunit beta 2 [COPB2]) and evaluated the functions and molecular mechanisms of these proteins in prostate cancer (PCA) cell proliferation. Proteins extracted from surgically resected PCA tissues and adjacent tissues of 3 patients were analyzed by label-free quantitative proteomics. Read More

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http://dx.doi.org/10.1016/j.bbrc.2017.11.040DOI Listing
January 2018
6 Reads

Clinical significance of SCCRO (DCUN1D1) in prostate cancer and its proliferation-inhibiting effect on Lncap cells.

Eur Rev Med Pharmacol Sci 2017 Oct;21(19):4283-4291

Department of Urology, Tianjin Union Medical Center, Hongqiao District, Tianjin, China.

Objective:   SCCRO/DCUN1D1/DCN1 (squamous cell carcinoma-related oncogene/defective in cullin neddylation 1 domain containing 1/defective in cullin neddylation) is considered as an oncogene, but its role in the prostate cancer (PC) is still not clear. The current study aims to investigate the expression of SCCRO in PC tumor tissues, further its clinical significance, and proliferation inhibiting effect on PC cells in vitro.

Patients And Methods: RT-PCR was used to detect the expression of SCCRO in PC tissue and corresponding adjacent normal tissues from 160 cases, and its relationship with clinical pathological characteristics was analyzed. Read More

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October 2017
7 Reads

Intensity-modulated radiation therapy for small cell carcinoma of the prostate: A case report.

Rep Pract Oncol Radiother 2017 Sep-Oct;22(5):349-353. Epub 2017 Jul 22.

Department of Radiation Oncology, Tokyo Women's Medical University School of Medicine, 8-1, Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.

Small cell carcinomas (SCC) make up only 1% of malignancies of the prostate. Reports of several case series have described outcomes of surgery and chemotherapy for SCC of the prostate, but few reports address radiotherapy. We treated a case of SCC of the prostate with intensity-modulated radiation therapy (IMRT) consisting of 70 Gy administered in 35 fractions followed by hormonal therapy using only luteinizing hormone-releasing hormone (LH-RH) agonist. Read More

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http://dx.doi.org/10.1016/j.rpor.2017.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524305PMC
July 2017
10 Reads

Prostate carcinoma with amphicrine features: further refining the spectrum of neuroendocrine differentiation in tumours of primary prostatic origin?

Histopathology 2017 Dec 6;71(6):926-933. Epub 2017 Oct 6.

Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Aims: The current World Health Organization classification categorises high-grade neuroendocrine (NE) carcinomas of the prostate into small-cell and large-cell types. A distinct form of carcinoma showing synchronous dual exocrine and NE differentiation, termed amphicrine carcinoma, has been described at various other sites, primarily within the gastrointestinal tract. The aim of this study was to investigate the clinicopathological features of a series of metastatic prostate carcinoma (PCa) cases with amphicrine features. Read More

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http://dx.doi.org/10.1111/his.13330DOI Listing
December 2017
21 Reads

Small-cell Carcinomas of the Urinary Bladder and Prostate: TERT Promoter Mutation Status Differentiates Sites of Malignancy and Provides Evidence of Common Clonality Between Small-cell Carcinoma of the Urinary Bladder and Urothelial Carcinoma.

Eur Urol Focus 2018 12 31;4(6):880-888. Epub 2017 Mar 31.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Urology, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address:

Background: Small-cell carcinoma (SCC) of the urinary bladder frequently appears alongside urothelial carcinoma, suggesting common clonality. TERT promoter mutations have been recently implicated in urothelial carcinogenesis.

Objective: To investigate the degree to which TERT promoter mutations are involved in SCC of the urinary bladder, the linked tumorigenesis between urothelial carcinoma and SCC of the urinary bladder, and the molecular distinctions between SCC of the urinary bladder and of the prostate. Read More

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http://dx.doi.org/10.1016/j.euf.2017.03.007DOI Listing
December 2018
27 Reads

Phosphatase and tensin homolog deleted on chromosome 10 degradation induced by NEDD4 promotes acquired erlotinib resistance in non-small-cell lung cancer.

Tumour Biol 2017 Jul;39(7):1010428317709639

Cancer Institute of PLA, Xinqiao Hospital, Third Military Medical University, Chongqing, P.R. China.

Acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors, such as gefitinib and erlotinib, is a critical issue in the treatment of patients with epidermal growth factor receptor mutant-positive non-small-cell lung cancer. Recent evidence suggests that downregulation of gene of phosphatase and tensin homolog deleted on chromosome 10 plays an important role in acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors in various types of cancers, including lung cancer. It was reported that the E3 ubiquitin ligase neural precursor cell expressed developmentally downregulated gene (NEDD4) (also known as NEDD4-1) negatively regulated phosphatase and tensin homolog deleted on chromosome 10 protein levels through poly-ubiquitination and proteolysis in carcinomas of the prostate, lung, and bladder. Read More

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http://dx.doi.org/10.1177/1010428317709639DOI Listing
July 2017
16 Reads

Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis.

Lancet Oncol 2017 08 7;18(8):1009-1021. Epub 2017 Jul 7.

Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, London, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, London, UK; Department of Medical Oncology, University College London Hospitals, London, UK. Electronic address:

Background: The focus of tumour-specific antigen analyses has been on single nucleotide variants (SNVs), with the contribution of small insertions and deletions (indels) less well characterised. We investigated whether the frameshift nature of indel mutations, which create novel open reading frames and a large quantity of mutagenic peptides highly distinct from self, might contribute to the immunogenic phenotype.

Methods: We analysed whole-exome sequencing data from 5777 solid tumours, spanning 19 cancer types from The Cancer Genome Atlas. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14702045173051
Publisher Site
http://dx.doi.org/10.1016/S1470-2045(17)30516-8DOI Listing
August 2017
63 Reads

Pure small cell recurrent prostate cancer developing syndrome of inappropriate antidiuretic hormone secretion.

Tumori 2017 Nov 15;103(Suppl. 1):e56-e59. Epub 2017 Nov 15.

Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan - Italy.

Purpose: Pure small cell neuroendocrine carcinoma of the prostate is a rare entity characterized by a poor prognosis due to early metastatic spread as well as resistance to treatment. Considering its increasing occurrence, clinicians should be aware of its aggressive behavior, the relevance of an early diagnosis, and proper management.

Methods: A 71-year-old man treated with brachytherapy for localized low-risk prostate cancer developed widespread disease 7 years later with a prostate-specific antigen-negative neuroendocrine small cell phenotype. Read More

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http://dx.doi.org/10.5301/tj.5000651DOI Listing
November 2017
28 Reads

FOXA2 is a sensitive and specific marker for small cell neuroendocrine carcinoma of the prostate.

Mod Pathol 2017 09 16;30(9):1262-1272. Epub 2017 Jun 16.

Department of Pathology, Duke University School of Medicine, Durham, NC, USA.

The median survival of patients with small cell neuroendocrine carcinoma is significantly shorter than that of patients with classic acinar-type adenocarcinoma. Small cell neuroendocrine carcinoma is traditionally diagnosed based on histologic features because expression of current immunohistochemical markers is inconsistent. This is a challenging diagnosis even for expert pathologists and particularly so for pathologists who do not specialize in prostate cancer. Read More

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http://dx.doi.org/10.1038/modpathol.2017.44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330177PMC
September 2017
25 Reads

Severe Cushing's syndrome due to small cell prostate carcinoma: a case and review of literature.

Endocr Connect 2017 Jul 5;6(5):R80-R86. Epub 2017 Jun 5.

Waikato Clinical CampusUniversity of Auckland, Hamilton, New Zealand

Cushing's syndrome (CS) due to ectopic adrenocorticotrophic hormone (ACTH) is associated with a variety of tumours most of which arise in the thorax or abdomen. Prostate carcinoma is a rare but important cause of rapidly progressive CS. To report a case of severe CS due to ACTH production from prostate neuroendocrine carcinoma and summarise previous published cases. Read More

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http://dx.doi.org/10.1530/EC-17-0081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510445PMC
July 2017
7 Reads

Successful Radiotherapy for Advanced Small Cell Carcinoma of the Prostate with Syndrome of Inappropriate Secretion of Antidiuretic Hormone.

Urol Case Rep 2017 Jul 22;13:147-148. Epub 2017 May 22.

Department of Urology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo City, Yamanashi, Japan.

Small cell carcinoma of the prostate (SCCP) is rare in clinical practice. It is often accompanied with the syndrome of inappropriate antidiuretic hormone secretion (SIADH). We present a case of SCCP with SIADH that was successfully treated with radiotherapy in the metastatic lymphnodes and prostate. Read More

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http://dx.doi.org/10.1016/j.eucr.2017.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440674PMC
July 2017
20 Reads

Contemporary Incidence and Cancer Control Outcomes of Primary Neuroendocrine Prostate Cancer: A SEER Database Analysis.

Clin Genitourin Cancer 2017 10 13;15(5):e793-e800. Epub 2017 Apr 13.

Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Canada.

Introduction: Neuroendocrine carcinoma of the prostate (NEPC) is a rare entity. We aimed at providing contemporary data on incidence and survival figures of de-novo NEPC.

Materials And Methods: Within the Surveillance, Epidemiology, and End Results (SEER) database, we identified 309 individuals with de-novo NEPC diagnosed between 2004 and 2013. Read More

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http://dx.doi.org/10.1016/j.clgc.2017.04.006DOI Listing
October 2017
40 Reads

Small Cell Carcinoma of the Prostate: A Case Report and Brief Review of the Literature.

Urol Case Rep 2017 Jul 26;13:61-62. Epub 2017 Apr 26.

University of Illinois, College of Medicine at Chicago, USA.

Small cell carcinoma of the prostate (SCCP) is a rare disorder. We present here a case of SCCP exhibiting multiple unique clinical findings, demonstrating the variability of SCCP at presentation. Read More

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http://dx.doi.org/10.1016/j.eucr.2016.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408139PMC
July 2017
4 Reads

Acute progressive paravascular placoid neuroretinopathy with negative-type electroretinography in paraneoplastic retinopathy.

Doc Ophthalmol 2017 06 5;134(3):227-235. Epub 2017 Apr 5.

Centre for Ophthalmology and Vision Science, The University of Western Australia, Perth, WA, Australia.

Purpose: Paraneoplastic retinopathy can be the first manifestation of systemic malignancy. A subset of paraneoplastic retinopathy is characterized by negative-type electroretinography (ERG) without fundus abnormality. Here we describe the multimodal imaging and clinico-pathological correlation of a unique case of acute progressive paravascular placoid neuroretinopathy with suspected retinal depolarizing bipolar cell dysfunction preceding the diagnosis of metastatic small cell carcinoma of the prostate. Read More

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http://dx.doi.org/10.1007/s10633-017-9587-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427140PMC
June 2017
8 Reads

Systematic Review Links the Prevalence of Intraductal Carcinoma of the Prostate to Prostate Cancer Risk Categories.

Eur Urol 2017 10 22;72(4):492-495. Epub 2017 Mar 22.

Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University, Melbourne, Australia; Prostate Cancer Research Program, Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Australia; Department of Physiology, Biomedicine Discovery Institute, Monash University, Melbourne, Australia. Electronic address:

Intraductal carcinoma of the prostate (IDC-P) is associated with poor prognosis. While it is often regarded as a rare pathology, the prevalence of IDC-P remains unclear, with variable reports from small and disparate patient populations. To determine how common IDC-P is across the spectrum of prostate cancer, we conducted a systematic review correlating IDC-P prevalence with prostate cancer risk. Read More

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http://dx.doi.org/10.1016/j.eururo.2017.03.013DOI Listing
October 2017
22 Reads

Small Cell Carcinoma of the Prostate in an Elderly Patient: A Case Report and Review of the Literature.

Rare Tumors 2016 Nov 20;8(4):6657. Epub 2016 Dec 20.

Departments of Radiation Oncology, Mayo Clinic , Jacksonville, FL, USA.

Prostate cancer is the most common malignancy of men in the United States. Small-cell carcinoma (SCC), which typically presents as an aggressive lung malignancy, is a rare diagnosis within the setting of prostate cancer pathology. Due to its limited prevalence, little information regarding the treatment and prognosis of this disease in large populations is available. Read More

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http://dx.doi.org/10.4081/rt.2016.6657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226053PMC
November 2016
18 Reads

[Etoposide and Carboplatin Effective for Treatment of Small Cell Carcinoma of Prostate : A Report of Two Cases].

Hinyokika Kiyo 2016 Dec;62(12):639-645

The Department of Urology, Osaka Rosai Hospital.

Case 1 : A 76-year-old man consulted a physician because of pollakisuria, decline of urinary stream. A high level of serum prostate specific antigen (PSA) was detected and he came to our hospital. He was diagnosed to have prostate cancer, cT3aN0M1b, and was treated with combined androgen blockage (CAB). Read More

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http://dx.doi.org/10.14989/ActaUrolJap_62_12_639DOI Listing
December 2016
3 Reads

A Vector-Based Short Hairpin RNA Targeting Aurora B Suppresses Human Prostatic Carcinoma Growth.

Technol Cancer Res Treat 2017 02 17;16(1):112-119. Epub 2016 Oct 17.

1 Key Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan University, Chengdu, People's Republic of China.

Aurora kinase B, playing a vital, important role in mitosis, is frequently detected to be overexpressed in many cancer cell lines and various tumor tissues, including prostatic carcinoma. Given the essential function of Aurora kinase B in mitosis and its association with tumorigenesis, it might be a drug target for prostatic carcinoma treatment. In our study, short hairpin RNA targeting Aurora kinase B was cloned into a pGPU6 plasmid vector and then transfected into human prostatic carcinoma cells. Read More

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http://dx.doi.org/10.1177/1533034616673534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5616121PMC
February 2017
11 Reads

Unusual Cushing's Syndrome and Hypercalcitoninaemia due to a Small Cell Prostate Carcinoma.

Case Rep Endocrinol 2016 1;2016:6308058. Epub 2016 Dec 1.

Pathology Unit, "M. Bufalini" Hospital, ASL of Romagna, Cesena, Italy.

A 75-year-old man was hospitalized because of severe hypokalaemia due to ACTH dependent Cushing's syndrome. Total body computed tomography (TBCT) and 68 Gallium DOTATATE PET/CT localized a voluminous prostate tumour. A subsequent transurethral prostate biopsy documented a small cell carcinoma positive for ACTH and calcitonin and negative for prostatic specific antigen (PSA) at immunocytochemical study; serum prostatic specific antigen (PSA) was normal. Read More

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http://dx.doi.org/10.1155/2016/6308058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156792PMC
December 2016
9 Reads

Preclinical Evaluation of F-PSMA-1007, a New Prostate-Specific Membrane Antigen Ligand for Prostate Cancer Imaging.

J Nucl Med 2017 03 27;58(3):425-431. Epub 2016 Oct 27.

Division of Radiopharmaceutical Chemistry, German Cancer Research Center, INF 280, Heidelberg, Germany; and.

In recent years, several radiotracers targeting the prostate-specific membrane antigen (PSMA) have been introduced. Some of them have had a high clinical impact on the treatment of patients with prostate cancer. However, the number of F-labeled tracers addressing PSMA is still limited. Read More

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http://jnm.snmjournals.org/lookup/doi/10.2967/jnumed.116.181
Publisher Site
http://dx.doi.org/10.2967/jnumed.116.181768DOI Listing
March 2017
39 Reads

Small-cell neuroendocrine cancer of the prostate: an atypical presentation of a common disease.

BMJ Case Rep 2016 Oct 5;2016. Epub 2016 Oct 5.

Serviço de Urologia e Transplantação Renal, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

A 70-year-old man with a history of prostate cancer, previously submitted to surgical castration and trans-urethral resection of the prostate, was admitted to Accident and Emergency department. He had been suffering from osteoarticular and abdominal pain, and recent weight loss. An abdominal and a pelvic CT showed multiple hepatic metastases and a pelvic mass, but his prostate-specific antigen values were low (0. Read More

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http://dx.doi.org/10.1136/bcr-2016-216199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073671PMC
October 2016
10 Reads

High-Content Screening Identifies Src Family Kinases as Potential Regulators of AR-V7 Expression and Androgen-Independent Cell Growth.

Prostate 2017 01 4;77(1):82-93. Epub 2016 Oct 4.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.

Background: AR-V7 is an androgen receptor (AR) splice variant that lacks the ligand-binding domain and is isolated from prostate cancer cell lines. Increased expression of AR-V7 is associated with the transition from hormone-sensitive prostate cancer to more advanced castration-resistant prostate cancer (CRPC). Due to the loss of the ligand-binding domain, AR-V7 is not responsive to traditional AR-targeted therapies, and the mechanisms that regulate AR-V7 are still incompletely understood. Read More

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http://dx.doi.org/10.1002/pros.23251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956900PMC
January 2017
18 Reads

Pure small cell carcinoma of the prostate preceded by acute zonal occult outer retinopathy: A case report.

Int J Surg Case Rep 2016 22;28:97-100. Epub 2016 Sep 22.

Department of Urology, Fiona Stanley Hospital, Perth, WA, Australia.

Introduction: Pure small cell prostate cancer (SCPC) cases are very rare. Acute zonal occult outer retinopathy (AZOOR) has been described as a non-neoplastic retinopathy. We report the first case of pure SCPC preceded by AZOOR in the literature. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045564PMC
http://dx.doi.org/10.1016/j.ijscr.2016.09.001DOI Listing
September 2016
10 Reads

Lentivirus-mediated p21/Waf-1 short hairpin RNA enhances the cytotoxic effects and replicative potential of a bladder cancer-specific oncolytic adenovirus in vitro.

Anticancer Drugs 2017 01;28(1):88-96

aInstitute of Cell Biology, School of Life Sciences bDepartment of Pharmacology, School of Basic Medical Sciences, Lanzhou University cKey Laboratory of Urological Diseases in Gansu Province, Department of Urology, Institute of Urology, The Second Hospital of Lanzhou University, Lanzhou, China dDepartment of Urology, University of Texas Health Science Center, San Antonio, Texas, USA.

Our previous work confirmed that the bladder cancer-specific oncolytic adenovirus Ad/PSCAE/UPII/E1A could selectively replicate in bladder cancer cells, thus causing specific tumor cell lysis. The replicative potential is a crucial factor in determining the therapeutic efficacy of oncolytic adenoviruses. However, viral replication is attenuated by the low-activity promoter that we used, thus compromising viral cytotoxicity. Read More

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http://dx.doi.org/10.1097/CAD.0000000000000433DOI Listing
January 2017
14 Reads

Tumors and Tumorlike Conditions of the Anal Canal and Perianal Region: MR Imaging Findings.

Radiographics 2016 Sep-Oct;36(5):1339-53

From the Department of Radiology, University of Texas Health Science Center, 6431 Fannin St, MSB 2.130, Houston, TX 77030 (V.R.S.); Department of Radiology, Mayo Clinic, Scottsdale, Ariz (C.O.M., A.K.H.); Department of Radiology, University of Texas MD Anderson Cancer Center, Houston, Tex (A.M.A., M.E., K.M.E.); Department of Radiology, University of Texas Health Science Center, San Antonio, Tex (V.S.K.); Department of Radiology, MetroHealth Medical Center, Cleveland, Ohio (W.C.B.); Department of Radiology, University of Ottawa, Ottawa, Ontario, Canada (A.K.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (C.L.S.).

Tumors and tumorlike conditions of the anus and perianal region originate from the anal canal and anal margin or result from direct extension of tumors from adjacent organs. The anatomy of the anal canal is complex, and its different histologic characteristics can lead to diverse pathologic conditions. The anal canal extends from the anorectal junction to the anal verge. Read More

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http://dx.doi.org/10.1148/rg.2016150209DOI Listing
September 2017
25 Reads

Genetic variants of genes in the Notch signaling pathway predict overall survival of non-small cell lung cancer patients in the PLCO study.

Oncotarget 2016 Sep;7(38):61716-61727

Duke Cancer Institute, Duke University Medical Center, Durham, NC 27710, USA.

The Notch signaling pathway has been shown to have biological significance and therapeutic application in non-small cell lung cancer (NSCLC). We hypothesize that genetic variants of genes in the Notch signaling pathway are associated with overall survival (OS) of NSCLC patients. To test this hypothesis, we performed multivariate Cox proportional hazards regression analysis to evaluate associations of 19,571 single nucleotide polymorphisms (SNPs) in 132 Notch pathway genes with OS of 1,185 NSCLC patients available from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. Read More

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http://dx.doi.org/10.18632/oncotarget.11436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308685PMC
September 2016
22 Reads
5 Citations
6.360 Impact Factor

Emerging trends in the evaluation and management of small cell prostate cancer: a clinical and molecular perspective.

Expert Rev Anticancer Ther 2016 Oct 26;16(10):1029-37. Epub 2016 Aug 26.

a Department of Urology , Indiana University School of Medicine , Indianapolis , IN , USA.

Introduction: Prostatic small cell carcinoma (PSCC) is a rare, aggressive form of prostate cancer associated with poor clinical outcomes. It can arise de novo or in the setting of castrate resistant adenocarcinoma of the prostate. Current therapeutic interventions are based upon observations the PSCC responds similarly to small cell carcinoma of the lung. Read More

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http://dx.doi.org/10.1080/14737140.2016.1226137DOI Listing
October 2016
4 Reads

Neuronal Trans-Differentiation in Prostate Cancer Cells.

Prostate 2016 10 12;76(14):1312-25. Epub 2016 Jul 12.

Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston, Houston, Texas.

Background: Neuroendocrine (NE) differentiation in prostate cancer (PCa) is an aggressive phenotype associated with therapy resistance. The complete phenotype of these cells is poorly understood. Clinical classification is based predominantly on the expression of standard NE markers. Read More

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http://dx.doi.org/10.1002/pros.23221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815867PMC
October 2016
11 Reads
2 Citations
3.565 Impact Factor

An Unusual Etiology of Urinary Retention - Small Cell Prostate Carcinoma.

Urol Case Rep 2016 Jul 20;7:53-4. Epub 2016 May 20.

SUNY Upstate Medical University, Syracuse, NY, USA.

We report the case of a 63-year-old male who presented with painless gross hematuria and urinary retention. Pathology obtained from transurethral resection of the prostate revealed pure small cell carcinoma of the prostate. Metastatic evaluation confirmed stage IV disease with lymphatic and hepatic metastasis. Read More

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http://dx.doi.org/10.1016/j.eucr.2016.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909518PMC
July 2016
7 Reads

Recurrent verrucous carcinoma of the urinary bladder after transurethral resection followed by intravesical mitomycin, and a review of the literature.

BMJ Case Rep 2016 Jun 15;2016. Epub 2016 Jun 15.

Department of Pathology, Shifa International Hospital Islamabad, Islamabad, Pakistan.

Verrucous carcinoma (VC) is a locally invasive, non-metastasising well differentiated variant of squamous cell carcinoma. It is very rare in the urinary bladder and mostly associated with schistosomiasis. It has a characteristic multilobular appearance with small surface projections on contrast cystogram. Read More

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http://casereports.bmj.com/content/2016/bcr-2016-216146.full
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http://dx.doi.org/10.1136/bcr-2016-216146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932366PMC
June 2016
9 Reads

Extrapulmonary Small Cell Carcinoma of the Seminal Vesicles and Prostate Demonstrated on 18F-FDG Positron Emission Tomography/Computed Tomography.

Mol Imaging Radionucl Ther 2016 Feb;25(1):47-9

Nepean Hospital, Department of Nuclear Medicine and PET, Penrith, Australia Phone: +61247342156 E-mail:

Extrapulmonary primary small cell carcinomas arising from the urogenital tract is infrequent. It can rarely arise from the prostate and even more rarely from the seminal vesicles. We present a 79-year-old male who was admitted due to acute renal failure with a history of radical radiotherapy for prostate adenocarcinoma 13 years ago. Read More

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http://dx.doi.org/10.4274/mirt.02997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807350PMC
February 2016
22 Reads

Retrospective Analysis of Atypical Glands Suspicious for Carcinoma in Transurethral Resection of Prostate.

Appl Immunohistochem Mol Morphol 2018 03;26(3):186-191

Department of Pathology and Laboratory Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, RI.

Prostate biopsies with foci of atypical glands suspicious, but not diagnostic of carcinoma (ATYP) are associated with an increased risk of cancer diagnosis in subsequent biopsies. The significance of similar findings in transurethral resections of the prostate (TURP) is unknown. A total of 1338 specimens without a diagnosis of cancer were retrieved from our surgical pathology files from 1994 through 2014. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000407DOI Listing
March 2018
7 Reads

Low grade urothelial carcinoma mimicking basal cell hyperplasia and transitional metaplasia in needle prostate biopsy.

Int Braz J Urol 2016 Mar-Apr;42(2):247-52

Departamento de Patología, Instituto Nacional de Ciencias Médicas y Nutrición, Distrito Federal, Mexico.

Purpose: The vast majority of urothelial carcinomas infiltrating the bladder are consistente with high-grade tumors that can be easily recognized as malignant in needle prostatic biopsies. In contrast, the histological changes of low-grade urothelial carcinomas in this kind of biopsy have not been studied.

Materials And Methods: We describe the clinicopathologic features of two patients with low-grade bladder carcinomas infiltrating the prostate. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871384PMC
http://dx.doi.org/10.1590/S1677-5538.IBJU.2014.0512DOI Listing
March 2017
3 Reads

Superporous Poly(ethylene glycol) Diacrylate Cryogel with a Defined Elastic Modulus for Prostate Cancer Cell Research.

Small 2016 Aug 30;12(29):3985-94. Epub 2016 May 30.

Karlsruhe Institute of Technology, Institute of Toxicology and Genetics, Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany.

The physical and mechanical properties of the tumor microenvironment are crucial for the growth, differentiation and migration of cancer cells. However, such microenvironment is not found in the geometric constraints of 2D cell culture systems used in many cancer studies. Prostate cancer research, in particular, suffers from the lack of suitable in vitro models. Read More

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http://dx.doi.org/10.1002/smll.201600683DOI Listing
August 2016
16 Reads
1 Citation
8.370 Impact Factor

Small cell carcinoma of the prostate presenting with Cushing Syndrome. A narrative review of an uncommon condition.

Ann Med 2016 11;48(4):293-9. Epub 2016 Apr 11.

a Department of Internal Medicine , Hospital Universitario de Fuenlabrada , Madrid , Spain ;

Small cell carcinoma (SCC) of the prostate is an uncommon condition; there are very few cases in which presenting symptoms are consistent with Cushing Syndrome (CS). We report a new case in which CS triggers the suspicion of an SCC of the prostate and a review of the published cases of SCC of the prostate presenting with CS. The origin of these neoplasms is still unclear. Read More

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http://dx.doi.org/10.3109/07853890.2016.1168936DOI Listing
January 2017
21 Reads