Search Our Scientific Publications & Authors

Leuk Res Rep 2021 14;15:100244. Epub 2021 May 14.

Department of Hematopathology and Lab Medicine, Moffitt Cancer Center, Tampa, FL, USA.

Introduction: Myelodysplastic syndrome (MDS) are hematologic neoplasms characterized by morphologic dysplasia and ineffective hematopoiesis in the bone marrow. The only potentially curative therapy is stem cell transplant. However, relapse remains a major challenge and is seen in about 25-40% of cases. Read More

BMC Cancer 2021 Jun 7;21(1):676. Epub 2021 Jun 7.

Mallorca Cancer Registry, Balearic Islands Public Health Department, Palma, Spain.

Background: Information about survival by stage in bladder cancer is scarce, as well as about survival of non-invasive bladder cancer. The aims of this study are: 1) to find out the distribution of bladder cancer by stage; 2) to determine cancer-specific survival by stage of bladder cancer; 3) to identify factors that explain and predict the likelihood of survival and the risk of dying from these cancers.

Methods: Incident bladder cancer cases diagnosed between 2006 and 2011 were identified through the Mallorca Cancer Registry. Read More

J Cancer 2021 19;12(14):4341-4354. Epub 2021 May 19.

Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong 518000, P.R. China.

Chromosome 19 open reading frame 10 (C19orf10) is a myocardial repair mediator overexpressed in hepatocellular carcinoma. However, its function and clinical value in bladder cancer (BC) have not been reported. This study aimed to investigate the role of C19orf10 in BC progression and explore underlying mechanisms. Read More

Biomark Res 2021 Jun 5;9(1):44. Epub 2021 Jun 5.

Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.

Background: The E-Cadherin gene (CDH1, Cadherin 1), located at 16q22.1 encodes for a calcium-dependent membranous glycoprotein with an important role in cellular adhesion and polarity maintenance.

Methods: To systematically determine E-Cadherin protein expression in normal and cancerous tissues, 14,637 tumor samples from 112 different tumor types and subtypes as well as 608 samples of 76 different normal tissue types were analyzed by immunohistochemistry in a tissue microarray format. Read More

Urol Oncol 2021 May 31. Epub 2021 May 31.

Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada.

Objective: Carbonic anhydrase IX (CA9) is important in the regulation of intra- and extracellular pH in solid tumors, contributing to cell growth and invasion. In urothelial carcinoma (UC), CA9 has been identified as a urinary marker for disease detection, but its biologic role is unknown. To date, differential gene expression patterns of CA9 in various molecular subtypes and potential effects of CA9 inhibition in UC cells are unknown. Read More

Am J Surg Pathol 2021 Jun 2. Epub 2021 Jun 2.

Departments of Pathology Radiology Medical Oncology, British Columbia Cancer Vancouver Centre Department of Urology, Vancouver General Hospital Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada Department of Pathology, MD Anderson Cancer Center, Houston, TX.

Large cell neuroendocrine carcinoma (LCNEC) of the urinary tract is a rare disease. We present a relatively large retrospective cohort of urinary LCNEC, 20 from the urinary bladder, and 2 from the ureter, from a single institution. The patients included 16 men and 6 women with a median age of 74. Read More

Cancers (Basel) 2021 May 19;13(10). Epub 2021 May 19.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Thymic carcinomas account for less than 0.01% of new cancer diagnoses annually and are more aggressive than thymomas. Autoimmune disorders have been associated with thymomas and only recently with thymic carcinomas. Read More

J Pathol Transl Med 2021 Jun 1. Epub 2021 Jun 1.

Department of Pathology, Ewha Womans University Seoul Hospital, Seoul, Korea.

A sarcomatoid variant of urothelial carcinoma in the female urethral diverticulum has not been reported previously. A 66-year-old woman suffering from dysuria presented with a huge urethral mass invading the urinary bladder and vagina. Histopathological examination of the resected specimen revealed predominantly undifferentiated pleomorphic sarcoma with sclerosis. Read More

Cytopathology 2021 May 24. Epub 2021 May 24.

Cytology Unit, Dubai Hospital, Dubai, United Arab Emirates.

FASEB J 2021 Jun;35(6):e21603

Department of Neurosurgery, the First Hospital of Jilin University, Changchun, China.

Extracellular matrix (ECM) plays an important role in the progression of cancer. Collagen is the most abundant component in ECM, and it is involved in the biological formation of cancer. Although type XI collagen is a minor fibrillar collagen, collagen XI alpha 1 chain (COL11A1) has been found to be upregulated in a variety of cancers including ovarian cancer, breast cancer, thyroid cancer, pancreatic cancer, non-small-cell lung cancer, and transitional cell carcinoma of the bladder. Read More

Eur Urol Oncol 2021 May 8. Epub 2021 May 8.

Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Context: Bladder and kidney cancers require invasive procedures for definitive diagnosis, and bladder cancer requires repeated procedures to monitor for disease recurrence. Given the recent work to identify molecular alterations in liquid biopsies to diagnose and monitor these diseases, a synthesis of the growing body of evidence is merited.

Objective: To review current data on cell-free DNA (cfDNA) and circulating tumor DNA (ctDNA) and to synthesize their roles in the diagnosis, monitoring, and prognostication of bladder and kidney cancer. Read More

Eur J Clin Invest 2021 May 10:e13583. Epub 2021 May 10.

University of Ioannina, Ioannina, Greece.

Background: Cancers of unknown primary (CUP) are highly aggressive tumours with limited molecular characterization. These tumours can be particularly sensitive to immune checkpoint inhibitors (ICI) by mounting a seemingly more effective anti-tumour immune response. Unlike other tumour lineages, the biological basis and clinical efficacy of ICI in CUP remain largely unknown. Read More

Front Oncol 2021 22;11:651754. Epub 2021 Apr 22.

Department of Pathology and Laboratory Medicine, The Miriam Hospital, The Warren Alpert Medical School of Brown University, Providence, RI, United States.

Small cell carcinoma of the urinary tract (SCCUT) is a rare finding with poor clinical course. This study sheds light on the molecular subtype and identifies risk factors in patients diagnosed with SCCUT. Immunohistochemical expression of immunotherapy target programmed death ligand 1 (PD-L1) and luminal (GATA3), basal (p63), and p53 markers are assessed in patients diagnosed with SCCUT. Read More

Eur J Cancer 2021 Jul 2;151:1-2. Epub 2021 May 2.

Department of Thoracic and Vascular Surgery, Sainte Anne Military Hospital, 2 Boulevard Sainte Anne, BP 600, 83000, Toulon, France.

Appl Immunohistochem Mol Morphol 2021 Apr 23. Epub 2021 Apr 23.

Departments of Urology Oncolocy Pathology, Johns Hopkins University School of Medicine Johns Hopkins Greenberg Bladder Cancer Institute, Baltimore, MD.

The antibody-drug conjugate enfortumab-vedotin acts by targeting nectin-4, a protein that is nearly ubiquitously expressed in conventional urothelial cancer. However, expression of nectin-4 in morphologic variants of urothelial carcinoma and nonurothelial histotypes was unknown. Immunohistochemistry for nectin-4 using was performed on 169 patients including 83 with nonmuscle invasive bladder cancer and 86 patients with muscle invasive bladder cancer. Read More

Adv Ther 2021 Jun 21;38(6):2759-2778. Epub 2021 Apr 21.

AstraZeneca, Gaithersburg, MD, USA.

The introduction of immunotherapy has fundamentally transformed the treatment landscape in cancer, providing long-term survival benefit for patients with advanced disease across multiple tumor types, including non-small cell lung cancer (NSCLC). In the placebo-controlled phase 3 PACIFIC trial, the PD-L1 inhibitor durvalumab demonstrated significant improvements in progression-free survival and overall survival in patients with unresectable, stage III NSCLC who had not progressed after platinum-based chemoradiotherapy (CRT). These findings have led to the widespread acceptance of the 'PACIFIC regimen' (durvalumab after CRT) as the standard of care in this setting. Read More

Int J Surg Case Rep 2021 May 16;82:105785. Epub 2021 Mar 16.

Division of Colon and Rectal Surgery, Department of Surgery, Tri-Service General Hospital, No. 325, Sec. 2, Chenggong Rd., Neihu District, Taipei City, 11490, Taiwan, ROC.

Introduction: Bladder urothelial carcinoma rarely spreads to the gastrointestinal tract, and its presentation in the rectum varies. We report a case of a patient who presented with an annular constriction of the rectum.

Presentation Of Case: A 60-year-old man was referred to our hospital with chief complaints of anal stricture and partial obstruction for about 1 month. Read More

Open Med (Wars) 2021 30;16(1):498-511. Epub 2021 Mar 30.

Department of Gastrointestinal Surgery, Lishui People's Hospital, No. 15 Dazhong Road, Liandu District, Lishui 323000, Zhejiang, China.

Background: Malignant tumors were considered as the leading causes of cancer-related mortality globally. More and more studies found that dysregulated genes played an important role in carcinogenesis. The aim of this study was to explore the significance of KPNA2 in human six major cancers including non-small cell lung cancer (NSCLC), gastric cancer, colorectal cancer, breast cancer, hepatocellular carcinoma, and bladder cancer based on bioinformatics analysis. Read More

Orv Hetil 2021 04 2;162(15):579-586. Epub 2021 Apr 2.

1 Semmelweis Egyetem, Általános Orvostudományi Kar, Urológiai Klinika, Budapest, Üllői út 78/B, 1082.

Összefoglaló. Az immunrendszer nem megfelelő működése meghatározó szerepet játszik a daganatok kialakulásában, progressziójában és az egyes terápiák hatékonyságában is. A bélrendszer baktériumai a szervezet immunitásán keresztül képesek befolyásolni a szervezet gyógyszeres terápiákra adott válaszreakcióját, kiváltképpen az immunellenőrzőpont-gátló kezelések hatását. Read More

Zhonghua Yi Xue Za Zhi 2021 Mar;101(12):861-865

Department of Urology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To evaluate the clinical features, surgical effects and factors that may affect prognosis of muscular invasive bladder cancer in young people. The clinical data of young (aged 44 and below) patients with muscle invasive bladder cancer who underwent robot-assisted radical cystectomy at the First Affiliated Hospital of Zhengzhou University from October 1st, 2014 to October 31st, 2018 were retrospectively analyzed, which included age, gender, body mass index (BMI), tumor discovery method, tumor location, tumor size, comorbid diseases, operation time, intraoperative blood loss, urinary diversion method, postoperative complications, postoperative hospital stay, postoperative pathology and follow-up results. A total of 24 patients were enrolled in this study, and 18(75%) were male and 6(25%) were female. Read More

Mol Med Rep 2021 Jun 31;23(6). Epub 2021 Mar 31.

Department of Urology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.

ABT‑737 is a recently reported inhibitor of members of the Bcl‑2 family of apoptosis regulators. However, to the best of our knowledge, its necroptosis‑inducing function in bladder cancer has not yet been researched. Thus, the present study aimed to investigate whether this Bcl‑2 family inhibitor can induce both apoptosis and necroptosis of urothelial carcinoma cells. Read More

Front Oncol 2021 10;11:650937. Epub 2021 Mar 10.

Department of Medical Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

Previous studies have revealed an increased risk of second primary malignancies (SPMs) after colorectal cancer (CRC); however, no previous investigation has quantified differences in the risk of SPMs based on the histological subtypes of first primary CRC. Patients diagnosed with first primary CRC between 2000 and 2011 were identified from the Surveillance, Epidemiology, and End Results cancer registries. The patients were divided into three cohorts: classical adenocarcinoma (CA), mucinous adenocarcinoma (MA), and signet-ring cell carcinoma (SRCC). Read More

Pol Przegl Chir 2020 Jul;93(1):1-5

Department of Surgery All India Institute Of Medical Sciences, Rishikesh Uttarakhand, India.

<b>Introduction:</b> Gall bladder (GB) small cell carcinoma (SCC) comprises 0.5% of all gall bladder cancers. It carries a poor prognosis in view of its aggressive nature. Read More

J Clin Med 2021 Feb 14;10(4). Epub 2021 Feb 14.

Department of Urology, Medical University of Innsbruck, 6020 Innsbruck, Austria.

Although Bacillus Calmette Guérin (BCG) remains a mainstay of adjuvant treatment in high-risk, non-muscle-invasive bladder cancer, BCG failure occurs in up to 40% of patients, with radical cystectomy (RC) as the inevitable therapeutic consequence. Current data suggest that PD-L1 immunosuppressive signaling is responsible for BCG failure, supporting the therapeutic rationale of combining checkpoint inhibitors with BCG. To address the immune cascade in 19 RC specimens obtained after BCG failure, we applied a small immunohistochemical (IHC) panel consisting of selected markers (PD-L1, GATA-3, a disintegrin and metalloproteinase (ADAM) proteases, IL-10/IL-10R). Read More

Cancer Control 2021 Jan-Dec;28:1073274821997455

Department of Urology, 12579Southeast University Affiliated Zhongda Hospital, Nanjing, Jiangsu, China.

Background: Recent studies have shown that methyltransferase-like 3, a catalytic enzyme that is predominant in the N6-methyladenosine methyltransferase system, is abnormally expressed in various types of carcinoma and is correlated with poorer prognosis. However, the clinical functions of methyltransferase-like 3 in the prognosis of tumors are not fully understood.

Methods: We identified studies by searching PubMed, Web of Science, and MedRvix for literature (up to June 30, 2020), and collected a total of 9 studies with 1257 patients for this meta-analysis. Read More

J Clin Pathol 2021 Feb 22. Epub 2021 Feb 22.

Division of Anatomical Pathology, University of Cape Town, Cape Town, South Africa.

Carbonic anhydrase IX (CAIX) is a transmembrane metalloenzyme which is upregulated in tumour cells under hypoxic conditions. CAIX expression is induced by the accumulation of hypoxia-inducible factor-1α and has several downstream effects, including acidification of the extracellular pH, loss of cellular adhesion and increased tumour cell migration. CAIX is upregulated in a variety of solid organ tumours and has prognostic implications. Read More

Int J Urol 2021 05 16;28(5):593-597. Epub 2021 Feb 16.

Department of Urology, Mayo Clinic Hospital, Phoenix, Arizona, USA.

Objectives: To compare ureteroenteric stricture rates after radical cystectomy in patients who undergo an intracorporeal urinary diversion versus other surgical approaches.

Methods: We retrospectively reviewed health records of all patients who underwent cystectomy with urinary diversion at Mayo Clinic Hospital (Phoenix, AZ, USA) from 1 January 2007 through 1 January 2018. Ureteroenteric stricture was identified by surveillance imaging. Read More

Expert Rev Mol Diagn 2021 Feb 22;21(2):161-173. Epub 2021 Feb 22.

Department of Mental and Physic Health and Preventive Medicine, Pathology Unit, University of Campania Luigi Vanvitelli, Napoli, Italy.

: Multitarget FISH (mFISH) is a technique allowing for simultaneous detection of multiple targets sequences on the same slide through the choice of spectrally distinct fluorophore labels. The mFISH could represent a useful tool in the field of precision oncology.: This review discusses the potential applications of mFISH technology in the molecular diagnosis of different solid and hematological tumors, including non-small cell lung cancers, melanomas, renal cell carcinomas, bladder carcinomas, germ cell tumors, and multiple myeloma, as commonly required in the clinical practice. Read More

Int J Radiat Oncol Biol Phys 2021 Feb 6. Epub 2021 Feb 6.

Department of Medical Oncology, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom; Cancer Sciences Unit, University of Southampton, Southampton, United Kingdom.

Purpose: Small cell carcinoma of the bladder (SCCB) is rare, accounting for less than 1% of all bladder carcinomas. It is aggressive, and outcomes are poor as a result of its early metastatic spread. Owing to its rarity, there are limitations on data to propose standardized management pathways. Read More

Environ Pollut 2021 Apr 28;275:116601. Epub 2021 Jan 28.

State Key Laboratory of Organic Geochemistry and Guangdong Province Key Laboratory of Environmental Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, China; Lancaster Environmental Centre, Lancaster University, LA1 4YQ, Lancaster, United Kingdom. Electronic address:

DNA methylation (DNAm) plays a significant role in deleterious health effects inflicted by fine particulate matter (PM) on the human body. Recent studies have reported that DNAm of imprinted control regions (ICRs) in imprinted genes may be a sensitive biomarker of environmental exposure. Less is known about specific biomarkers of imprinted genes after PM exposure. Read More