7,345 results match your criteria Small [Journal]


Screening Therapeutic Agents Specific to Breast Cancer Stem Cells Using a Microfluidic Single-Cell Clone-Forming Inhibition Assay.

Small 2019 Apr 18:e1901001. Epub 2019 Apr 18.

Department of Laboratory Medicine, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, 510180, China.

Screens of cancer stem cells (CSCs)-specific agents present significant challenges to conventional cell assays due to the difficulty in preparing CSCs ready for drug testing. To overcome this limitation, developed is a microfluidic single-cell assay for screening breast cancer stem cell-specific agents. This assay takes advantage of the single-cell clone-forming capability of CSCs, which can be specifically inhibited by CSC-targeting agents. Read More

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http://dx.doi.org/10.1002/smll.201901001DOI Listing
April 2019
1 Read

High-Stability MnO Nanowires@C@MnO Nanosheet Core-Shell Heterostructure Pseudocapacitance Electrode Based on Reversible Phase Transition Mechanism.

Small 2019 Apr 18:e1900862. Epub 2019 Apr 18.

Hebei Key Laboratory of Applied Chemistry, College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, 066004, China.

A stable MnO @C@MnO core-shell heterostructure consisting of vertical MnO nanosheets grown evenly on the surface of the MnO @carbon nanowires are obtained by simple liquid phase method combined with thermal treatment. The hierarchical MnO @C@MnO heterostructure electrode possesses a high specific capacitance of 350 F g and an excellent cycle performance owing to the existence of the pore structure among the ultrasmall MnO nanoparticles and the rapid transmission of electrons between the active material and carbon coating layer. Particularly, according to the in situ Raman spectra analysis, no characteristic peaks corresponding to MnOOH are found during charging/discharging, indicating that pseudocapacitive behavior of the MnO electrode have no relevance to the intercalation/deintercalation of protons (H ) in the electrolyte. Read More

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http://dx.doi.org/10.1002/smll.201900862DOI Listing

Building Carbon-Based Versatile Scaffolds on the Electrode Surface to Boost Capacitive Performance for Fiber Pseudocapacitors.

Small 2019 Apr 17:e1900721. Epub 2019 Apr 17.

Nanoyang Group, State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, Tianjin, 300072, China.

In order to fabricate high performance fiber pseudocapacitors, the trade-off between high mass loading and high utilization efficiency of pseudocapacitive materials should be carefully addressed. Here, a solution that is to construct a carbon-based versatile scaffold is reported for loading pseudocapacitive materials on carbonaceous fibers. The scaffold can be easily built by conformally coating commercial pen ink on the fibers without any destruction to the fiber skeleton. Read More

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http://dx.doi.org/10.1002/smll.201900721DOI Listing

Responsive Porous Microcarriers With Controllable Oxygen Delivery for Wound Healing.

Small 2019 Apr 17:e1901254. Epub 2019 Apr 17.

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.

Microcarriers with oxygen-delivering capacity have attracted increasing interest in the field of tissue regeneration. Here, a kind of molybdenum disulfide quantum dots (MoS QDs) integrated responsive porous microcarriers with controllable oxygen-delivering ability for wound healing is presented. The specific gelatin methacryloyl (GelMa) porous microcarriers are derived from inverse opal microparticles which can be decorated with the oxygen-carrying protein hemoglobin. Read More

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http://dx.doi.org/10.1002/smll.201901254DOI Listing
April 2019
2 Reads

Smart Microcapsules with Molecular Polarity- and Temperature-Dependent Permeability.

Small 2019 Apr 17:e1900434. Epub 2019 Apr 17.

Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea.

Microcapsules with molecule-selective permeation are appealing as microreactors, capsule-type sensors, drug and cell carriers, and artificial cells. To accomplish molecular size- and charge-selective permeation, regular size of pores and surface charges have been formed in the membranes. However, it remains an important challenge to provide advanced regulation of transmembrane transport. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.2019004
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http://dx.doi.org/10.1002/smll.201900434DOI Listing
April 2019
2 Reads

Precise Surface Engineering of Cathode Materials for Improved Stability of Lithium-Ion Batteries.

Small 2019 Apr 17:e1901019. Epub 2019 Apr 17.

CAS Key Laboratory of Molecular Nanostructure and Nanotechnology, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences (CAS), Beijing, 100190, P. R. China.

As lithium-ion batteries continue to climb to even higher energy density, they meanwhile cause serious concerns on their stability and reliability during operation. To make sure the electrode materials, particularly cathode materials, are stable upon extended cycles, surface modification becomes indispensable to minimize the undesirable side reaction at the electrolyte-cathode interface, which is known as a critical factor to jeopardizing the electrode performance. This Review is targeted at a precise surface control of cathode materials with focus on the synthetic strategies suitable for a maximized surface protection ensured by a uniform and conformal surface coating. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.2019010
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http://dx.doi.org/10.1002/smll.201901019DOI Listing
April 2019
2 Reads

Ball-Mill-Exfoliated Graphene: Tunable Electrochemistry and Phenol Sensing.

Small 2019 Apr 17:e1805567. Epub 2019 Apr 17.

Key Laboratory for Material Chemistry of Energy Conversion and Storage, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China.

A simple wet ball-milling method for exfoliating pristine graphite to graphene nanosheets is proposed. The surfactant of cetyltrimethyl ammonium bromide is utilized to greatly improve the exfoliation efficiency of graphene nanosheets. Variation of the ball-milling time is an efficient way to control the size and thickness of graphene nanosheets, as well as the level of edge defects. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.2018055
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http://dx.doi.org/10.1002/smll.201805567DOI Listing
April 2019
4 Reads

Cell Encapsulation in Soft, Anisometric Poly(ethylene) Glycol Microgels Using a Novel Radical-Free Microfluidic System.

Small 2019 Apr 16:e1900692. Epub 2019 Apr 16.

DWI-Leibniz Institute for Interactive Materials, Forckenbeckstrasse 50, 52074, Aachen, Germany.

Complex 3D artificial tissue constructs are extensively investigated for tissue regeneration. Frequently, materials and cells are delivered separately without benefitting from the synergistic effect of combined administration. Cell delivery inside a material construct provides the cells with a supportive environment by presenting biochemical, mechanical, and structural signals to direct cell behavior. Read More

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http://dx.doi.org/10.1002/smll.201900692DOI Listing

Alternatives to Cryogenic Distillation: Advanced Porous Materials in Adsorptive Light Olefin/Paraffin Separations.

Small 2019 Apr 17:e1900058. Epub 2019 Apr 17.

Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117585, Singapore.

As primary feedstocks in the petrochemical industry, light olefins such as ethylene and propylene are mainly obtained from steam cracking of naphtha and short chain alkanes (ethane and propane). Due to their similar physical properties, the separations of olefins and paraffins-pivotal processes to meet the olefin purity requirement of downstream processing-are typically performed by highly energy-intensive cryogenic distillation at low temperatures and high pressures. To reduce the energy input and save costs, adsorptive olefin/paraffin separations have been proposed as promising techniques to complement or even replace cryogenic distillation, and growing efforts have been devoted to developing advanced adsorbents to fulfill this challenging task. Read More

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http://dx.doi.org/10.1002/smll.201900058DOI Listing

α-Fe O Nanoparticles Decorated C@MoS Nanosheet Arrays with Expanded Spacing of (002) Plane for Ultrafast and High Li/Na-Ion Storage.

Small 2019 Apr 16:e1901083. Epub 2019 Apr 16.

School of Environmental and Chemical Engineering, Shanghai University, 99 Shangda Road, Shanghai, 200444, P. R. China.

MoS nanosheets as a promising 2D nanomaterial have extensive applications in energy storage and conversion, but their electrochemical performance is still unsatisfactory as an anode for efficient Li /Na storage. In this work, the design and synthesis of vertically grown MoS nanosheet arrays, decorated with graphite carbon and Fe O nanoparticles, on flexible carbon fiber cloth (denoted as Fe O @C@MoS /CFC) is reported. When evaluated as an anode for lithium-ion batteries, the Fe O @C@MoS /CFC electrode manifests an outstanding electrochemical performance with a high discharge capacity of 1541. Read More

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http://dx.doi.org/10.1002/smll.201901083DOI Listing

Monitoring Nanocrystal Self-Assembly in Real Time Using In Situ Small-Angle X-Ray Scattering.

Small 2019 Apr 16:e1900438. Epub 2019 Apr 16.

Deutsches Elektronen-Synchrotron (DESY), Notkestraße 85, 22607, Hamburg, Germany.

Self-assembled nanocrystal superlattices have attracted large scientific attention due to their potential technological applications. However, the nucleation and growth mechanisms of superlattice assemblies remain largely unresolved due to experimental difficulties to monitor intermediate states. Here, the self-assembly of colloidal PbS nanocrystals is studied in real time by a combination of controlled solvent evaporation from the bulk solution and in situ small-angle X-ray scattering (SAXS) in transmission geometry. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.2019004
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http://dx.doi.org/10.1002/smll.201900438DOI Listing
April 2019
6 Reads

Temperature Gradients Drive Bulk Flow Within Microchannel Lined by Fluid-Fluid Interfaces.

Small 2019 Apr 16:e1900472. Epub 2019 Apr 16.

Physical Intelligence Department, Max Planck Institute for Intelligent Systems, Stuttgart, 70569, Germany.

Surface tension gradients induce Marangoni flow, which may be exploited for fluid transport. At the micrometer scale, these surface-driven flows can be quite significant. By introducing fluid-fluid interfaces along the walls of microfluidic channels, bulk fluid flows driven by temperature gradients are observed. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.2019004
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http://dx.doi.org/10.1002/smll.201900472DOI Listing
April 2019
2 Reads

Self-Healing, Adhesive, and Highly Stretchable Ionogel as a Strain Sensor for Extremely Large Deformation.

Small 2019 Apr 16:e1804651. Epub 2019 Apr 16.

Kavli Institute for Bionano Science and Technology, John A. Paulson School of Engineering and Applied Science, Harvard University, Cambridge, MA, 02138, USA.

Fabricating a strain sensor that can detect large deformation over a curved object with a high sensitivity is crucial in wearable electronics, human/machine interfaces, and soft robotics. Herein, an ionogel nanocomposite is presented for this purpose. Tuning the composition of the ionogel nanocomposites allows the attainment of the best features, such as excellent self-healing (>95% healing efficiency), strong adhesion (347. Read More

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http://dx.doi.org/10.1002/smll.201804651DOI Listing
April 2019
1 Read

Precise Patterning of Organic Semiconductor Crystals for Integrated Device Applications.

Small 2019 Apr 16:e1900332. Epub 2019 Apr 16.

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou Jiangsu, 215123, P. R. China.

Development of high-performance organic electronic and optoelectronic devices relies on high-quality semiconducting crystals that have outstanding charge transport properties and long exciton diffusion length and lifetime. To achieve integrated device applications, it is a prerequisite to precisely locate the organic semiconductor crystals (OSCCs) to form a specifically patterned structure. Well-patterned OSCCs can not only reduce leakage current and cross-talk between neighboring devices, but also facilely integrate with other device elements and their corresponding interconnects. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.2019003
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http://dx.doi.org/10.1002/smll.201900332DOI Listing
April 2019
1 Read

Recent Progress in Molecular Design of Fused Ring Electron Acceptors for Organic Solar Cells.

Authors:
Somnath Dey

Small 2019 Apr 16:e1900134. Epub 2019 Apr 16.

Department of Chemistry, Texas A&M University at Qatar, P.O. Box 23874, Doha, Qatar.

The quest for sustainable energy sources has led to accelerated growth in research of organic solar cells (OSCs). A solution-processed bulk-heterojunction (BHJ) OSC generally contains a donor and expensive fullerene acceptors (FAs). The last 20 years have been devoted by the OSC community to developing donor materials, specifically low bandgap polymers, to complement FAs in BHJs. Read More

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http://dx.doi.org/10.1002/smll.201900134DOI Listing

Dynamic Nanostructures from DNA-Coupled Molecules, Polymers, and Nanoparticles.

Small 2019 Apr 15:e1900504. Epub 2019 Apr 15.

Department of Chemistry and Nanoscience, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul, 03760, Korea.

Dynamic and reconfigurable systems that can sense and react to physical and chemical signals are ubiquitous in nature and are of great interest in diverse areas of science and technology. DNA is a powerful tool for fabricating such smart materials and devices due to its programmable and responsive molecular recognition properties. For the past couple of decades, DNA-based self-assembly is actively explored to fabricate various DNA-organic and DNA-inorganic hybrid nanostructures with high-precision structural control. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.2019005
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http://dx.doi.org/10.1002/smll.201900504DOI Listing
April 2019
2 Reads

Impact of Locally Administered Carboxydextran-Coated Super-Paramagnetic Iron Nanoparticles on Cellular Immune Function.

Small 2019 Apr 15:e1900224. Epub 2019 Apr 15.

MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge, CB2 0XZ, UK.

Interstitially administered iron oxide particles are currently used for interoperative localization of sentinel lymph nodes (LNs) in cancer staging. Several studies have described concerns regarding the cellular accumulation of iron oxide nanoparticles relating them to phenotype and function deregulation of macrophages, impairing their ability to mount an appropriate immune response once an insult is present. This study aims to address what phenotypic and functional changes occur during lymphatic transit and accumulation of these particles. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.2019002
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http://dx.doi.org/10.1002/smll.201900224DOI Listing
April 2019
1 Read

Broadband High-Efficiency Chiral Splitters and Holograms from Dielectric Nanoarc Metasurfaces.

Small 2019 Apr 15:e1900483. Epub 2019 Apr 15.

Nanophotonics Research Centre, Shenzhen Key Laboratory of Micro-Scale Optical Information Technology, Shenzhen University, Shenzhen, 518060, China.

Simultaneous broadband and high efficiency merits of designer metasurfaces are currently attracting widespread attention in the field of nanophotonics. However, contemporary metasurfaces rarely achieve both advantages simultaneously. For the category of transmissive metadevices, plasmonic or conventional dielectric metasurfaces are viable for either broadband operation with relatively low efficiency or high efficiency at only a selection of wavelengths. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.2019004
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http://dx.doi.org/10.1002/smll.201900483DOI Listing
April 2019
1 Read

Biopebble Containers: DNA-Directed Surface Assembly of Mesoporous Silica Nanoparticles for Cell Studies.

Small 2019 Apr 15:e1900083. Epub 2019 Apr 15.

Karlsruhe Institute of Technology (KIT), Institute for Biological Interfaces (IBG 1), Hermann-von-Helmholtz-Platz, D-76344, Eggenstein-Leopoldshafen, Germany.

The development of methods for colloidal self-assembly on solid surfaces is important for many applications in biomedical sciences. Toward this goal, described is a versatile class of mesoporous silica nanoparticles (MSN) that contain on their surface various types of DNA molecules to enable their self-assembly into micropatterned surface architectures useful for cell studies. Monodisperse dye-doped MSN are synthesized by biphase stratification and functionalized with an aptamer oligonucleotide that serves as gatekeeper for the triggered release of encapsulated molecular cargo, such as fluorescent dye rhodamine B or the anticancer drug doxorubicin. Read More

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http://dx.doi.org/10.1002/smll.201900083DOI Listing

A Molecular Hero Suit for In Vitro and In Vivo DNA Nanostructures.

Small 2019 Apr 15:e1805386. Epub 2019 Apr 15.

Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.

Precise control of DNA base pairing has rapidly developed into a field full of diverse nanoscale structures and devices that are capable of automation, performing molecular analyses, mimicking enzymatic cascades, biosensing, and delivering drugs. This DNA-based platform has shown the potential of offering novel therapeutics and biomolecular analysis but will ultimately require clever modification to enrich or achieve the needed "properties" and make it whole. These modifications total what are categorized as the molecular hero suit of DNA nanotechnology. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.2018053
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http://dx.doi.org/10.1002/smll.201805386DOI Listing
April 2019
1 Read

Artificial Photosynthesis with Polymeric Carbon Nitride: When Meeting Metal Nanoparticles, Single Atoms, and Molecular Complexes.

Small 2019 Apr 12:e1900772. Epub 2019 Apr 12.

International Research Center for Renewable Energy, State Key Laboratory of Multiphase Flow in Power Engineering, Xi'an Jiaotong University, Xi'an, 710049, China.

Artificial photosynthesis for solar water splitting and CO reduction to produce hydrogen and hydrocarbon fuels has been considered as one of the most promising ways to solve increasingly serious energy and environmental problems. As a well-documented metal-free semiconductor, polymeric carbon nitride (PCN) has been widely used and intensively investigated for photocatalytic water splitting and CO reduction, owing to its physicochemical stability, visible-light response, and facile synthesis. However, PCN as a photocatalyst still suffers from the fast recombination of electron-hole pairs and poor water redox reaction kinetics, greatly restricting its activity for artificial photosynthesis. Read More

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http://dx.doi.org/10.1002/smll.201900772DOI Listing

Development of Dip-Pen Nanolithography (DPN) and Its Derivatives.

Small 2019 Apr 12:e1900564. Epub 2019 Apr 12.

Laboratory for Advanced Interfacial Materials and Devices, Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, 999077, Hong Kong SAR, China.

Dip-pen nanolithography (DPN) is a unique nanofabrication tool that can directly write a variety of molecular patterns on a surface with high resolution and excellent registration. Over the past 20 years, DPN has experienced a tremendous evolution in terms of applicable inks, a remarkable improvement in fabrication throughput, and the development of various derivative technologies. Among these developments, polymer pen lithography (PPL) is the most prominent one that provides a large-scale, high-throughput, low-cost tool for nanofabrication, which significantly extends DPN and beyond. Read More

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http://dx.doi.org/10.1002/smll.201900564DOI Listing

Amorphous Mn O Nanocages with High-Efficiency Charge Transfer for Enhancing Electro-Optic Properties of Liquid Crystals.

Small 2019 Apr 12:e1805475. Epub 2019 Apr 12.

Beijing Advanced Innovation Center for Biomedical Engineering, Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology, Ministry of Education, School of Chemistry, Beihang University, Beijing, 100191, P. R. China.

Improving electro-optic properties is essential for fabricating high-quality liquid crystal displays. Herein, by doping amorphous Mn O octahedral nanocages (a-Mn O ONCs) into a nematic liquid crystal (NLC) matrix E7, outstanding electro-optic properties of the blend are successfully obtained. At a doping concentration of 0. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.2018054
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http://dx.doi.org/10.1002/smll.201805475DOI Listing
April 2019
6 Reads

Highly Reproducible Physiological Asymmetric Membrane with Freely Diffusing Embedded Proteins in a 3D-Printed Microfluidic Setup.

Small 2019 Apr 12:e1900725. Epub 2019 Apr 12.

Laboratoire de Physique de l'Ecole Normale Supérieure, PSL Research University, CNRS, Sorbonne Université, Université Sorbonne Paris Cité, Paris, 75005, France.

Experimental setups to produce and to monitor model membranes have been successfully used for decades and brought invaluable insights into many areas of biology. However, they all have limitations that prevent the full in vitro mimicking and monitoring of most biological processes. Here, a suspended physiological bilayer-forming chip is designed from 3D-printing techniques. Read More

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http://dx.doi.org/10.1002/smll.201900725DOI Listing

Intrinsically Optimizing Charge Transfer via Tuning Charge/Discharge Mode for Lithium-Oxygen Batteries.

Small 2019 Apr 12:e1900154. Epub 2019 Apr 12.

Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry-of-Education Key Laboratory for Synthesis and Applications of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan, 430062, P. R. China.

Lithium-oxygen batteries have an ultrahigh theoretical energy density, almost ten times higher than lithium-ion batteries. The poor conductivity of the discharge product Li O , however, severely raises the charge overpotential and pulls down the cyclability. Here, a simple and effective strategy is presented for regular formation of lithium vacancies in the discharge product via tuning charge/discharge mode, and their effects on the charge transfer behavior. Read More

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http://dx.doi.org/10.1002/smll.201900154DOI Listing
April 2019
1 Read

Flexible Micropillar Electrode Arrays for In Vivo Neural Activity Recordings.

Small 2019 Apr 12:e1900582. Epub 2019 Apr 12.

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China.

Flexible electronics that can form tight interfaces with neural tissues hold great promise for improving the diagnosis and treatment of neurological disorders and advancing brain/machine interfaces. Here, the facile fabrication of a novel flexible micropillar electrode array (µPEA) is described based on a biotemplate method. The flexible and compliant µPEA can readily integrate with the soft surface of a rat cerebral cortex. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.2019005
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http://dx.doi.org/10.1002/smll.201900582DOI Listing
April 2019
2 Reads

Specific K Binding Sites as CO Traps in a Porous MOF for Enhanced CO Selective Sorption.

Small 2019 Apr 12:e1900426. Epub 2019 Apr 12.

National Institute for Advanced Materials, Tianjin Key Laboratory of Metal and Molecule-Based Material Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin, 300350, P. R. China.

Metal-organic frameworks (MOFs) can be fine-tuned to boost sorbent-sorbate interactions in order to improve gas sorption and separation performance, but the design of MOFs with ideal structural features for gas separation applications remains a challenge. Herein it is reported that unsaturated alkali metal sites can be immobilized in MOFs through a tetrazole based motif and that gas affinity can thereby be boosted. In the prototypal MOF of this type-NKU-521 (NKU denotes Nankai University), K cations are effectively embedded in a trinuclear Co -tetrazole coordination motif. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.2019004
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http://dx.doi.org/10.1002/smll.201900426DOI Listing
April 2019
2 Reads

Comment on "Topical Delivery of Avastin to the Posterior Segment of the Eye In Vivo Using Annexin A5-Associated Liposomes": Topical Liposomal Bevacizumab Results in Negligible Retinal Concentrations.

Authors:
Arto Urtti

Small 2019 Apr 14;15(15):e1805199. Epub 2019 Mar 14.

Laboratory of Biohybrid Technologies, Institute of Chemistry, St. Petersburg State University, Peterhoff Campus, Universitetskii pr. 26, 198504, St. Petersburg, Russia.

The previously published report suggests that liposomes, functionalized with annexin-5, can deliver bevacizumab to the retina after topical administration as eyedrops. Topical delivery of bevacizumab would be an attractive alternative to the current treatment that involves monthly intravitreal injections to the eye. In this Comment, the retinal concentrations of topically applied liposomal bevacizumab are compared to the levels reached after intravitreal injections. Read More

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http://dx.doi.org/10.1002/smll.201805199DOI Listing

Polyproline Tri-Helix Macrocycles as Nanosized Scaffolds to Control Ligand Patterns for Selective Protein Oligomer Interactions.

Small 2019 Apr 12:e1900561. Epub 2019 Apr 12.

Department of Chemistry, National Tsing Hua University, Hsinchu, 30013, Taiwan.

Multivalent ligand-receptor interactions play essential roles in biological recognition and signaling. As the receptor arrangement on the cell surface can alter the outcome of cell signaling and also provide spatial specificity for ligand binding, controlling the presentation of ligands has become a promising strategy to manipulate or selectively target protein receptors. The lack of adjustable universal tools to control ligand positions at the size of a few nanometers has prompted the development of polyproline tri-helix macrocycles as scaffolds to present ligands in designated patterns. Read More

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http://dx.doi.org/10.1002/smll.201900561DOI Listing

Chemical Properties, Structural Properties, and Energy Storage Applications of Prussian Blue Analogues.

Small 2019 Apr 12:e1900470. Epub 2019 Apr 12.

Institute for Superconducting and Electronic Materials, University of Wollongong, Wollongong, NSW, 2522, Australia.

Prussian blue analogues (PBAs, A T[M(CN) ], A = Li, K, Na; T = Fe, Co, Ni, Mn, Cu, etc.; M = Fe, Mn, Co, etc.) are a large family of materials with an open framework structure. Read More

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http://dx.doi.org/10.1002/smll.201900470DOI Listing

Key Aspects of Lithium Metal Anodes for Lithium Metal Batteries.

Small 2019 Apr 11:e1900687. Epub 2019 Apr 11.

Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences Shenyang, Liaoning, 110016, China.

Rechargeable batteries are considered promising replacements for environmentally hazardous fossil fuel-based energy technologies. High-energy lithium-metal batteries have received tremendous attention for use in portable electronic devices and electric vehicles. However, the low Coulombic efficiency, short life cycle, huge volume expansion, uncontrolled dendrite growth, and endless interfacial reactions of the metallic lithium anode are major obstacles in their commercialization. Read More

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http://dx.doi.org/10.1002/smll.201900687DOI Listing
April 2019
3 Reads

Nucleic Acid-Based Functional Nanomaterials as Advanced Cancer Therapeutics.

Small 2019 Apr 11:e1900172. Epub 2019 Apr 11.

Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (MOE), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300350, P. R. China.

Nucleic acid-based functional nanomaterials (NAFN) have been widely used as emerging drug delivery nanocarriers for cancer therapeutics. Considerable works have demonstrated that NAFN can effectively load and protect therapeutic agents, and particularly enable targeting delivery to the tumor site and stimuli-responsive release. These outstanding performances are due to NAFN's unique properties including inherent biological functions and sequence programmability as well as biocompatibility and biodegradability. Read More

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http://dx.doi.org/10.1002/smll.201900172DOI Listing

Recent Progress in Three-Terminal Artificial Synapses: From Device to System.

Small 2019 Apr 11:e1900695. Epub 2019 Apr 11.

Institute of Optoelectronic Thin Film Devices and Technology, Nankai University, Tianjin, 300350, China.

Synapses are essential to the transmission of nervous signals. Synaptic plasticity allows changes in synaptic strength that make a brain capable of learning from experience. During development of neuromorphic electronics, great efforts have been made to design and fabricate electronic devices that emulate synapses. Read More

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http://dx.doi.org/10.1002/smll.201900695DOI Listing
April 2019
8.368 Impact Factor

Modulation of Bi MoO -Based Materials for Photocatalytic Water Splitting and Environmental Application: a Critical Review.

Small 2019 Apr 10:e1901008. Epub 2019 Apr 10.

College of Environmental Science and Engineering, Hunan University, Changsha, 410082, P. R. China.

Highly active photocatalysts driving chemical reactions are of paramount importance toward renewable energy substitutes and environmental protection. As a fascinating Aurivillius phase material, Bi MoO has been the hotspot in photocatalytic applications due to its visible light absorption, nontoxicity, low cost, and high chemical durability. However, pure Bi MoO suffers from low efficiency in separating photogenerated carriers, small surface area, and poor quantum yield, resulting in low photocatalytic activity. Read More

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http://dx.doi.org/10.1002/smll.201901008DOI Listing

Dynamic DNA Structures.

Small 2019 Apr 10:e1900228. Epub 2019 Apr 10.

Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Department of Chemistry, Emory University, Atlanta, GA, 30322, USA.

Dynamic DNA structures, a type of DNA construct built using programmable DNA self-assembly, have the capability to reconfigure their conformations in response to environmental stimulation. A general strategy to design dynamic DNA structures is to integrate reconfigurable elements into conventional static DNA structures that may be assembled from a variety of methods including DNA origami and DNA tiles. Commonly used reconfigurable elements range from strand displacement reactions, special structural motifs, target-binding DNA aptamers, and base stacking components, to DNA conformational change domains, etc. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.2019002
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http://dx.doi.org/10.1002/smll.201900228DOI Listing
April 2019
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Programmable Atom Equivalents: Atomic Crystallization as a Framework for Synthesizing Nanoparticle Superlattices.

Small 2019 Apr 10:e1805424. Epub 2019 Apr 10.

Department of Materials Science and Engineering, Massachusetts Institute of Technology (MIT), 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.

Decades of research efforts into atomic crystallization phenomenon have led to a comprehensive understanding of the pathways through which atoms form different crystal structures. With the onset of nanotechnology, methods that use colloidal nanoparticles (NPs) as nanoscale "artificial atoms" to generate hierarchically ordered materials are being developed as an alternative strategy for materials synthesis. However, the assembly mechanisms of NP-based crystals are not always as well-understood as their atomic counterparts. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.2018054
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http://dx.doi.org/10.1002/smll.201805424DOI Listing
April 2019
2 Reads

Carbon-Based Alloy-Type Composite Anode Materials toward Sodium-Ion Batteries.

Small 2019 Apr 10:e1900628. Epub 2019 Apr 10.

Department of Mechanical Engineering, National University of Singapore, Singapore, 117574, Singapore.

In the scenario of renewable clean energy gradually replacing fossil energy, grid-scale energy storage systems are urgently necessary, where Na-ion batteries (SIBs) could supply crucial support, due to abundant Na raw materials and a similar electrochemical mechanism to Li-ion batteries. The limited energy density is one of the major challenges hindering the commercialization of SIBs. Alloy-type anodes with high theoretical capacities provide good opportunities to address this issue. Read More

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http://dx.doi.org/10.1002/smll.201900628DOI Listing
April 2019
8.368 Impact Factor

Self-Assembled Nickel Pyrophosphate-Decorated Amorphous Bimetal Hydroxides 2D-on-2D Nanostructure for High-Energy Solid-State Asymmetric Supercapacitor.

Small 2019 Apr 10:e1901145. Epub 2019 Apr 10.

School of Chemical Engineering, Chonnam National University 77, Yongbong-ro, Buk-gu, Gwangju, 61186, Republic of Korea.

To obtain a supercapacitor with a remarkable specific capacitance and rate performance, a cogent design and synthesis of the electrode material containing abundant active sites is necessary. In present work, a scalable strategy is developed for preparing 2D-on-2D nanostructures for high-energy solid-state asymmetric supercapacitors (ASCs). The self-assembled vertically aligned microsheet-structured 2D nickel pyrophosphate (Ni P O ) is decorated with amorphous bimetallic nickel cobalt hydroxide (NiCo-OH) to form a 2D-on-2D nanostructure arrays electrode. Read More

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http://dx.doi.org/10.1002/smll.201901145DOI Listing
April 2019
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Deep Learning to Speed up the Development of Structure-Property Relations For Hexagonal Boron Nitride and Graphene.

Small 2019 Apr 10:e1900656. Epub 2019 Apr 10.

Department of Civil and Environmental Engineering, Rice University, Houston, TX, 77005, USA.

Structure-property maps play a key role in accelerated materials discovery. The current norm for developing these maps includes computationally expensive physics-based simulations. Here, the capabilities of deep learning agents are explored such as convolutional neural networks (CNNs) and multilayer perceptrons (MLPs) to predict structure-property relations and reduce dependence on simulations. Read More

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http://dx.doi.org/10.1002/smll.201900656DOI Listing

Nanowire-Seeded Growth of Single-Crystalline (010) β-Ga O Nanosheets with High Field-Effect Electron Mobility and On/Off Current Ratio.

Small 2019 Apr 10:e1900580. Epub 2019 Apr 10.

Materials Genome Institute, Shanghai University, 333 Nanchen Road, Shanghai, 200444, China.

2D β-Ga O nanosheets, as fundamental materials, have great potential in next generations of ultraviolet transparent electrodes, high-temperature gas sensors, solar-blind photodetectors, and power devices, while their synthesis and growth with high crystalline quality and well-controlled orientation have not been reported yet. The present study demonstrates how to grow single-crystalline ultrathin quasi-hexagonal β-Ga O nanosheets with nanowire seeds and proposes a hierarchy-oriented growth mechanism. The hierarchy-oriented growth is initiated by epitaxial growth of a single-crystalline β-Ga O nanowire on a GaN nanocrystal and followed by homoepitaxial growth of quasi-hexagonal (010) β-Ga O nanosheets. Read More

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http://dx.doi.org/10.1002/smll.201900580DOI Listing

Covalently Linked Perylene Diimide-Polydiacetylene Nanofibers Display Enhanced Stability and Photocurrent with Reversible FRET Phenomenon.

Small 2019 Apr 10:e1901342. Epub 2019 Apr 10.

Department of Chemical Engineering, Hanyang University, Seoul, 04763, Korea.

Because of their unique structural and optical properties, 1D perylene diimide (PDI) derivatives have gained attention for use in optoelectronic devices. However, PDI-containing self-assembled supramolecular systems often are of limited use because they have supramolecular architectures that are held together by weak noncovalent π-π stacking, hydrogen bonding, and hydrophobic interactions. As a result, they are intrinsically unstable under solution-processing conditions. Read More

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http://dx.doi.org/10.1002/smll.201901342DOI Listing

A Sensitive Aptasensor Based on a Hemin/G-Quadruplex-Assisted Signal Amplification Strategy for Electrochemical Detection of Gastric Cancer Exosomes.

Small 2019 Apr 8:e1900735. Epub 2019 Apr 8.

Department of Clinical Laboratory, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, P. R. China.

Emerging evidence indicates that exosomes derived from gastric cancer cells enhance tumor migration and invasion through the modulation of the tumor microenvironment. However, it remains a major problem to detect cancer-specific exosomes due to technical and biological challenges. Most of the methods reported could not achieve efficient detection of tumor-derived exosomes in the background of normal exosomes. Read More

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http://dx.doi.org/10.1002/smll.201900735DOI Listing

Graphitic Hollow Nanocarbon as a Promising Conducting Agent for Solid-State Lithium Batteries.

Small 2019 Apr 8:e1900235. Epub 2019 Apr 8.

Next Generation Battery Research Center, Korea Electrotechnology Research Institute, 12, Bulmosan-ro 10beon-gil, Seongsan-gu, Changwon-si, Gyeongsangnam-do, 51543, Republic of Korea.

All-solid-state batteries (ASSBs) have lately received enormous attention for electric vehicle applications because of their exceptional stability by engaging all-solidified cell components. However, there are many formidable hurdles such as low ionic conductivity, interface instability, and difficulty in the manufacturing process, for its practical use. Recently, carbon, one of the representative conducting agents, turns out to largely participate in side reactions with the solid electrolyte, which finally leads to the formation of insulating side products at the interface. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.2019002
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http://dx.doi.org/10.1002/smll.201900235DOI Listing
April 2019
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8.368 Impact Factor

Cryo-EM-On-a-Chip: Custom-Designed Substrates for the 3D Analysis of Macromolecules.

Small 2019 Apr 8:e1900918. Epub 2019 Apr 8.

Virginia Tech Carilion Research Institute, Virginia Tech, Roanoke, VA, 24016, USA.

The fight against human disease requires a multidisciplinary scientific approach. Applying tools from seemingly unrelated areas, such as materials science and molecular biology, researchers can overcome long-standing challenges to improve knowledge of molecular pathologies. Here, custom-designed substrates composed of silicon nitride (SiN) are used to study the 3D attributes of tumor suppressor proteins that function in DNA repair events. Read More

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http://dx.doi.org/10.1002/smll.201900918DOI Listing

Interlayer Hydrogen-Bonded Metal Porphyrin Frameworks/MXene Hybrid Film with High Capacitance for Flexible All-Solid-State Supercapacitors.

Small 2019 Apr 8:e1901351. Epub 2019 Apr 8.

Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications (NUPT), 9 Wenyuan Road, Nanjing, 210023, P. R. China.

2D metal-porphyrin frameworks (MPFs) are attractive for advanced energy storage devices. However, the inferior conductivity and low structural stability of MPFs seriously limit their application as flexible free-standing electrodes with high performance. Here, for the first time, an interlayer hydrogen-bonded MXene/MPFs film is proposed to overcome these disadvantages by intercalation of highly conductive MXene nanosheets into MPFs nanosheets via a vacuum-assisted filtration technology. Read More

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http://dx.doi.org/10.1002/smll.201901351DOI Listing

Graphene-Assisted Growth of Patterned Perovskite Films for Sensitive Light Detector and Optical Image Sensor Application.

Small 2019 Apr 8:e1900730. Epub 2019 Apr 8.

School of Electronic Science and Applied Physics, Hefei University of Technology, Hefei, Anhui, 230009, China.

Controlled growth of high-quality patterned perovskite films on a large scale is essentially required for the application of this class of materials in functional integrated devices and systems. Herein, graphene-assisted hydrophilic-hydrophobic surface-induced growth of Cs-doped FAPbI perovskite films with well-patterned shapes by a one-step spin-coating process is developed. Such a facile fabrication technique is compatible with a range of spin-coated perovskite materials, perovskite manufacturing processes, and substrates. Read More

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http://dx.doi.org/10.1002/smll.201900730DOI Listing
April 2019
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8.368 Impact Factor

The Binary Effect on Methicillin-Resistant Staphylococcus aureus of Polymeric Nanovesicles Appended by Proline-Rich Amino Acid Sequences and Inorganic Nanoparticles.

Small 2019 Apr 8:e1804247. Epub 2019 Apr 8.

Department of Chemical Engineering, Northeastern University, Boston, MA, 02115, USA.

Prevalent research underscores efforts to engineer highly sophisticated nanovesicles that are functionalized to combat antibiotic-resistant bacterial infections, especially those caused by methicillin-resistant Staphylococcus aureus (MRSA), and that aid with wound healing or immunomodulation. This is especially relevant for patients who are susceptible to Staphylococcus aureus infections postoperatively. Here, antibacterial formulations are incorporated into polymeric, biocompatible vesicles called polymersomes (PsNPs) that self-assemble via hydrophobic interactions of admixed aqueous and organic substances. Read More

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http://dx.doi.org/10.1002/smll.201804247DOI Listing

2D Free-Standing Nitrogen-Doped Ni-Ni S @Carbon Nanoplates Derived from Metal-Organic Frameworks for Enhanced Oxygen Evolution Reaction.

Small 2019 Apr 8:e1900348. Epub 2019 Apr 8.

International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), Namiki 1-1, Tsukuba, Ibaraki, 305-0044, Japan.

2D metal-organic frameworks (2D MOFs) are promising templates for the fabrication of carbon supported 2D metal/metal sulfide nanocomposites. Herein, controllable synthesis of a newly developed 2D Ni-based MOF nanoplates in well-defined rectangle morphology is first realized via a pyridine-assisted bottom-up solvothermal treatment of NiSO and 4,4'-bipyridine. The thickness of the MOF nanoplates can be controlled to below 20 nm, while the lateral size can be tuned in a wide range with different amounts of pyridine. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.2019003
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http://dx.doi.org/10.1002/smll.201900348DOI Listing
April 2019
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Unveiling the Interfacial Effects for Enhanced Hydrogen Evolution Reaction on MoS /WTe Hybrid Structures.

Small 2019 Apr 8:e1900078. Epub 2019 Apr 8.

Department of Mechanical Engineering and Materials Science, Yale University, New Haven, CT, 06511, USA.

Using the MoS -WTe heterostructure as a model system combined with electrochemical microreactors and density function theory calculations, it is shown that heterostructured contacts enhance the hydrogen evolution reaction (HER) activity of monolayer MoS . Two possible mechanisms are suggested to explain this enhancement: efficient charge injection through large-area heterojunctions between MoS and WTe and effective screening of mirror charges due to the semimetallic nature of WTe . The dielectric screening effect is proven minor, probed by measuring the HER activity of monolayer MoS on various support substrates with dielectric constants ranging from 4 to 300. Read More

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http://dx.doi.org/10.1002/smll.201900078DOI Listing
April 2019
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Investigating the Optical Properties of a Laser Induced 3D Self-Assembled Carbon-Metal Hybrid Structure.

Small 2019 Apr 8:e1900512. Epub 2019 Apr 8.

Max Planck Institute for the Science of Light, 91058, Erlangen, Germany.

Carbon-based and carbon-metal hybrid materials hold great potential for applications in optics and electronics. Here, a novel material made of carbon and gold-silver nanoparticles is discussed, fabricated using a laser-induced self-assembly process. This self-assembled metamaterial manifests itself in the form of cuboids with lateral dimensions on the order of several micrometers and a height of tens to hundreds of nanometers. Read More

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http://dx.doi.org/10.1002/smll.201900512DOI Listing