562 results match your criteria Sleeplessness and Circadian Rhythm Disorder

Relationship between insomnia and rest time between shifts among shift workers: A multicenter cross-sectional study.

J Occup Health 2022 Jan;64(1):e12336

Department of Occupational and Environmental Medicine, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea.

Objectives: A rest time of less than 11 h taken by a shift worker between shifts is defined as quick return (QR). QR is shown to decrease sleep time by virtue of decreasing rest time, diminishing sleepiness and exhaustion, and increasing the number of sick days taken by employees. Therefore, in this multicenter retrospective study, the association between QR and the incidence of insomnia was established using the night-shift questionnaire from the Korean Workers Health Examination-Common Data Model. Read More

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January 2022

[Pre-pandemic melatonin treatment for sleep disorders and COVID-19 infection. A retrospective cross-sectional study].

Vertex 2022 Mar;XXXIII(155):13-24

Servicio de Neurología. Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Introduction: Melatonin is a safe medication with multiple uses in sleep medicine for the treatment of circadian rhythm disorders, insomnia, and REM sleep behavior disorder. In view that melatonin has been recommended as an adjuvant treatment in COVID-19 pandemic mainly due to its anti-inflammatory properties, the objective of the present study was to evaluate the history of COVID-19 infection and the requirement of hospitalization in a group of adult patients previously treated with melatonin for various sleep disorders.

Material And Methods: This is a retrospective cross-sectional study of data from a closed population of 110 adult patients at a University Hospital treated with melatonin for various sleep disorders, analyzed until the onset of COVID-19 pandemic. Read More

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Feasibility and preliminary efficacy for morning bright light therapy to improve sleep and plasma biomarkers in US Veterans with TBI. A prospective, open-label, single-arm trial.

PLoS One 2022 14;17(4):e0262955. Epub 2022 Apr 14.

Department of Neurology, Oregon Health & Science University, Portland, Oregon, United States of America.

Mild traumatic brain injury (TBI) is associated with persistent sleep-wake dysfunction, including insomnia and circadian rhythm disruption, which can exacerbate functional outcomes including mood, pain, and quality of life. Present therapies to treat sleep-wake disturbances in those with TBI (e.g. Read More

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Changes in sleep behavior, sleep problems, and psychological distress/health-related quality of life of young Japanese individuals before and during the COVID-19 pandemic.

Chronobiol Int 2022 06 9;39(6):781-791. Epub 2022 Feb 9.

Department of Somnology, Tokyo Medical University, Tokyo, Japan.

Social restrictions during the coronavirus disease (COVID-19) pandemic have impacted sleep behavior and sleep problems, and their related daytime functioning in young adults. However, no studies have examined such changes in young individuals from countries with mild infection intensity and social restrictions. Therefore, we focused on sleep behaviors and sleep issues in young people in Japan. Read More

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Insomnia subtypes characterised by objective sleep duration and NREM spectral power and the effect of acute sleep restriction: an exploratory analysis.

Sci Rep 2021 12 21;11(1):24331. Epub 2021 Dec 21.

CIRUS Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Sydney, Australia.

Insomnia disorder (ID) is a heterogeneous disorder with proposed subtypes based on objective sleep duration. We speculated that insomnia subtyping with additional power spectral analysis and measurement of response to acute sleep restriction may be informative in overall assessment of ID. To explore alternative classifications of ID subtypes, insomnia patients (n = 99) underwent two consecutive overnight sleep studies: (i) habitual sleep opportunity (polysomnography, PSG) and, (ii) two hours less sleep opportunity (electroencephalography, EEG), with the first night compared to healthy controls (n = 25). Read More

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December 2021

[Sleep disorders in patients with a neurocognitive disorder].

Encephale 2022 Jun 14;48(3):325-334. Epub 2021 Dec 14.

Centre de recherche de l'institut universitaire de gériatrie de Montréal, Montréal, Québec, Canada; Département de psychologie, université de Montréal, Montréal, Québec, Canada; Département de santé, kinésiologie et physiologie appliquée, centre d'études en neurobiologie comportementale et centre PERFORM, université Concordia, Montréal, Québec, Canada. Electronic address:

Introduction: Sleep disorders are prevalent in patients with a neurocognitive disorder, and diagnosis and treatment in these patients remain challenging in clinical practice.

Methods: This narrative review offers a systematic approach to diagnose and treat sleep disorders in neurocognitive disorders.

Results: Alzheimer's disease is often associated with circadian rhythm disorders, chronic insomnia, and sleep apnea-hypopnea syndrome. Read More

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Comparative efficacy of digital cognitive behavioral therapy for insomnia: A systematic review and network meta-analysis.

Sleep Med Rev 2022 02 10;61:101567. Epub 2021 Nov 10.

School of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan; Research Center of Sleep Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

The comparative efficacy of various approaches of digital cognitive behavioral therapy for insomnia (CBTi) is still unclear. This network meta-analysis explored the comparative efficacy of digital CBTi approaches in adults with insomnia. Four electronic databases were searched from inception to June 27, 2020. Read More

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February 2022

Treating Insomnia with High Risk of Depression Using Therapist-Guided Digital Cognitive, Behavioral, and Circadian Rhythm Support Interventions to Prevent Worsening of Depressive Symptoms: A Randomized Controlled Trial.

Psychother Psychosom 2022 6;91(3):168-179. Epub 2021 Dec 6.

Department of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.

Introduction: The global disease burden of major depressive disorder urgently requires prevention in high-risk individuals, such as recently discovered insomnia subtypes. Previous studies targeting insomnia with fully automated eHealth interventions to prevent depression are inconclusive: dropout was high and likely biased, and depressive symptoms in untreated participants on average improved rather than worsened.

Objective: This randomized controlled trial aimed to efficiently prevent the worsening of depressive symptoms by selecting insomnia subtypes at high risk of depression for internet-based circadian rhythm support (CRS), cognitive behavioral therapy for insomnia (CBT-I), or their combination (CBT-I+CRS), with online therapist guidance to promote adherence. Read More

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The effectiveness of an individualized sleep and shift work education and coaching program to manage shift work disorder in nurses: a randomized controlled trial.

J Clin Sleep Med 2022 04;18(4):1035-1045

Turner Institute for Brain and Mental Health, School of Psychological Sciences Monash University, Clayton, Victoria, Australia.

Study Objectives: While insomnia and sleepiness symptoms are common in shift workers, 20%-30% experience more severe symptoms and meet the criteria for shift work disorder (SWD). SWD can lead to impairments in cognitive function, physical and mental health, and reduced productivity and increased risk of workplace injury. The aim of this study was to deliver and evaluate a shift work individual management coaching program, focusing on sleep education, promoting good sleep hygiene, and providing individualized behavioral strategies to cope with shift schedules. Read More

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Sleep-Wake Disturbances: Common Side Effect.

Clin J Oncol Nurs 2021 12;25(6):33

University of California San Diego Moores Cancer Center.

For sleep-wake disturbances, standards of care are based on established evidence-based practice. Sleep-wake disturbances are defined as ongoing issues with sleep or daytime sleepiness (e.g. Read More

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December 2021

Associations of adverse childhood experiences with adolescent total sleep time, social jetlag, and insomnia symptoms.

Sleep Med 2021 12 21;88:104-115. Epub 2021 Oct 21.

Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA; Johns Hopkins Center on Aging and Health, Baltimore, MD, USA.

Study Objective: Adverse childhood experiences (ACEs) are associated with sleep problems in adulthood, but less research has focused on ACEs and sleep during adolescence. The goal of the present study was to explore associations between ACEs reported at ages 5 and 9 years, and sleep (ie, total sleep time (TST), social jetlag, and insomnia symptoms) at age 15.

Methods: Participants comprised 817 families from the Fragile Families and Child Wellbeing Study, a nationally representative sample of children born to unwed parents. Read More

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December 2021

Soporific effect of modified Suanzaoren Decoction on mice models of insomnia by regulating Orexin-A and HPA axis homeostasis.

Biomed Pharmacother 2021 Nov 10;143:112141. Epub 2021 Sep 10.

Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, No. 18, Chaowang Road, Xiacheng District, Hangzhou, Zhejiang 310014, China. Electronic address:

Aim: Modified Suanzaoren Decoction (MSZRD) is obtained by improving Suanzaoren Decoction (SZRT), a traditional Chinese herbal prescription that has been used to treat insomnia for more than thousands of years. Our previous study showed that MSZRD can improve the gastrointestinal discomfort related insomnia by regulating Orexin-A. This study is the first study to evaluate the effects and possible mechanisms of MSZRD in mice with insomnia caused by p-chlorophenylalanine (PCPA) combined with multifactor random stimulation. Read More

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November 2021

Treatment of Circadian Rhythm Sleep-Wake Disorders.

Curr Neuropharmacol 2022 ;20(6):1022-1034

Department of Neurology (Sleep Disorders), the Affiliated Chaohu Hospital of Anhui Medical University, Hefei 238000, Anhui Province, P.R. China.

Circadian rhythm sleep-wake disorders (CRSWDs) are a distinct class of sleep disorders caused by alterations to the circadian time-keeping system, its entrainment mechanisms, or a mismatch between the endogenous circadian rhythm and the external environment. The main clinical manifestations are insomnia and excessive daytime sleepiness that often lead to clinically meaningful distress or cause mental, physical, social, occupational, educational, or other functional impairment. CRSWDs are easily mistaken for insomnia or early waking up, resulting in inappropriate treatment. Read More

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Randomized Noninferiority Trial of Telehealth Delivery of Cognitive Behavioral Treatment of Insomnia Compared to In-Person Care.

J Clin Psychiatry 2021 08 24;82(5). Epub 2021 Aug 24.

Department of Psychiatry, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania.

Insomnia is prevalent and is associated with a range of negative sequelae. Cognitive behavioral treatment for insomnia (CBT-I) is the recommended intervention, but availability is limited. Telehealth provides increased access, but its efficacy is not certain. Read More

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The contribution of sleep to anorexia nervosa severity.

Eat Weight Disord 2022 May 23;27(4):1563-1568. Epub 2021 Aug 23.

Centre for Mental Health, Faculty of Health, Arts and Design, AMDC907, Swinburne University of Technology, John St, Hawthorn, VIC, 3122, Australia.

Purpose: Anorexia nervosa (AN) is associated with poor sleep and altered circadian rhythms. Evidence is unclear as to whether these features relate to ongoing psychiatric symptoms of AN, or are merely concomitant with low weight. In this study, we sought to evaluate subjective sleep quality and sleep-wake preferences in a sample of individuals with lifetime AN. Read More

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Night work as a stressor: The role of sleep reactivity to stress in the relationship between night work and insomnia.

J Sleep Res 2022 04 23;31(2):e13468. Epub 2021 Aug 23.

Department of Clinical Neurophysiology, Sleep Medicine Center, Institute of Psychiatry and Neurology, Warsaw, Poland.

Sleep reactivity to stress is a predisposition to experience sleep disturbances in response to stress. The present study aimed to examine the potential moderating role of sleep reactivity to stress in the relationship between the number of night shifts per month as a stressor and insomnia symptoms. A total of 188 shift-working physicians completed a short questionnaire about work schedule, the Ford Insomnia Response to Stress and the Insomnia Severity Index. Read More

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Treatment of Insomnia with Zaleplon in HIV+ Significantly Improves Sleep and Depression.

Psychopharmacol Bull 2021 06;51(3):50-64

Goldschmied, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA; Chronobiology and Sleep Institute, University of Pennsylvania, Philadelphia, PA. Sengupta, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA. Sharma, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA. Taylor, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA. Morales, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA; Department of Biostatistics, Epidemiology & Informatics, University of Pennsylvania, Philadelphia, PA. Thase, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA. Weljie, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA. Kayser, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA; Chronobiology and Sleep Institute, University of Pennsylvania, Philadelphia, PA.

More than 50% of individuals who are HIV positive report insomnia, which can reduce HIV treatment adherence, impair quality of life, and contribute to metabolic dysfunction. Major depressive disorder is also highly comorbid in this population, leading to further impairment. There is evidence that treating insomnia may improve not only sleep, but depression and metabolic function, as well. Read More

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Sleep disorders in people with type 2 diabetes and associated health outcomes: a review of the literature.

Diabetologia 2021 11 16;64(11):2367-2377. Epub 2021 Aug 16.

Department of Epidemiology and Data Science, Amsterdam UMC, location VUmc, Amsterdam, the Netherlands.

Sleep disorders are linked to development of type 2 diabetes and increase the risk of developing diabetes complications. Treating sleep disorders might therefore play an important role in the prevention of diabetes progression. However, the detection and treatment of sleep disorders are not part of standardised care for people with type 2 diabetes. Read More

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November 2021

Anonymous online cognitive behavioral therapy for sleep disorders in shift workers-a study protocol for a randomized controlled trial.

Trials 2021 Aug 16;22(1):539. Epub 2021 Aug 16.

Department of Medical Psychology and Medical Sociology, University Clinic for Psychiatry and Psychotherapy, Erlangen University Hospital, Friedrich-Alexander University Erlangen Nuremberg, Erlangen, Germany.

Background: Many shift workers suffer from sleep issues, which negatively affect quality of life and performance. Scientifically evaluated, structured programs for prevention and treatment are scarce. We developed an anonymous online cognitive behavioral therapy for insomnia (CBT-I) program. Read More

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Light therapy for the treatment of delayed sleep-wake phase disorder in adults: a systematic review.

Sleep Sci 2021 Apr-Jun;14(2):155-163

Escola Bahiana de Medicina e Saúde Pública, Pesquisa - Salvador - Bahia - Brazil.

Delayed sleep-wake phase disorder (DSWPD) is characterized by sleep onset times, beyond the usual schedules and social conveniences, which potentially impacts on health as well as on school and professional performance. The most common treatment for DSWPD is the light administration (light therapy), through light devices, with or without behavioral instructions. Since there is no consensus in the literature about its efficacy and how it should be processed, this study aims to evaluate the light therapy effectiveness in the delayed sleep-wake phase disorder therapeutics. Read More

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Depressed mood and repetitive negative thinking in Delayed Sleep-Wake Phase Disorder: Treatment effects and a comparison with good sleepers.

J Sleep Res 2022 02 4;31(1):e13452. Epub 2021 Aug 4.

College of Education, Psychology and Social Work, Flinders University, Adelaide, SA, Australia.

Circadian dysregulation and depressed mood commonly co-occur in young people, yet mechanisms linking Delayed Sleep-Wake Phase disorder (DSWPD) with depression are poorly understood. The present study aimed to examine the role of repetitive negative thinking (RNT), by comparing sleep, RNT and depressive symptomology between 40 'good' sleeping young people and 63 with DSWPD, with (n = 30) and without (n = 33) self-reported doctor-diagnosed depression. Secondary analysis from a randomised controlled trial was also undertaken to observe changes in depressive symptoms and RNT as a result of treatment for DSWPD. Read More

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February 2022

Sleep disorders in traumatic brain injury.

Neurocirugia (Astur : Engl Ed) 2021 Jul-Aug;32(4):178-187. Epub 2020 Dec 30.

Servicio de Neurocirugía, Hospital Universitario 12 de Octubre, Madrid, Spain.

The purpose of the review is to collect the most relevant current literature on the mechanisms of normal sleep and sleep disorders associated with traumatic brain injury (TBI), to discuss the most frequent conditions and the evidence on their possible treatments and future research. Sleep disorders are extremely prevalent after TBI (30-84%). Insomnia and circadian rhythm disorders are the most frequent disorders among the population that has suffered mild TBI, while hypersomnolence disorders are more frequent in populations that have suffered moderate and severe TBI. Read More

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Demographic, psychological, chronobiological, and work-related predictors of sleep disturbances during the COVID-19 lockdown in Italy.

Sci Rep 2021 06 1;11(1):11416. Epub 2021 Jun 1.

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio (Coppito 2), 67100, Coppito, AQ, Italy.

The first COVID-19 contagion wave caused unprecedented restraining measures worldwide. In Italy, a period of generalized lockdown involving home confinement of the entire population was imposed for almost two months (9 March-3 May 2020). The present is the most extensive investigation aimed to unravel the demographic, psychological, chronobiological, and work-related predictors of sleep disturbances throughout the pandemic emergency. Read More

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Chronic sleep restriction triggers inadequate napping habits in adolescents: a population-based study.

Sleep Med 2021 07 19;83:115-122. Epub 2021 Apr 19.

Human Chronobiology Laboratory, Department of Physiology, Biological Sciences Sector, Federal University of Paraná, Curitiba, Paraná, Brazil. Electronic address:

Background: The prevalence of chronic sleep restriction during adolescence is a major public health issue. Napping has been adopted to alleviate sleep pressure complaints. However, it also has the potential to amplify sleep restriction due to a vicious cycle triggered by delayed sleep times. Read More

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Depressive and stress symptoms in insomnia patients predict group cognitive-behavioral therapy for insomnia long-term effectiveness: A data-driven analysis.

J Affect Disord 2021 06 24;289:117-124. Epub 2021 Apr 24.

Sleep Disorder Center, San Raffaele Hospital Milan, Italy.

Background: Insomnia Disorder is characterized by high degree of phenotypic heterogeneity, that might influence treatment response.

Methods: 123 of 294 insomnia patients initially recruited (66.7% females, age=40. Read More

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Multitask fMRI and machine learning approach improve prediction of differential brain activity pattern in patients with insomnia disorder.

Sci Rep 2021 04 30;11(1):9402. Epub 2021 Apr 30.

Department of Psychiatry and Center for Sleep and Chronobiology, Seoul National University College of Medicine, Seoul, Republic of Korea.

We investigated the differential spatial covariance pattern of blood oxygen level-dependent (BOLD) responses to single-task and multitask functional magnetic resonance imaging (fMRI) between patients with psychophysiological insomnia (PI) and healthy controls (HCs), and evaluated features generated by principal component analysis (PCA) for discrimination of PI from HC, compared to features generated from BOLD responses to single-task fMRI using machine learning methods. In 19 patients with PI and 21 HCs, the mean beta value for each region of interest (ROIbval) was calculated with three contrast images (i.e. Read More

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Current Update on Clinically Relevant Sleep Issues in Parkinson's Disease: A Narrative Review.

Keisuke Suzuki

J Parkinsons Dis 2021 ;11(3):971-992

Department of Neurology, Dokkyo Medical University, Shimotsuga, Tochigi, Japan.

Sleep disturbances are among the common nonmotor symptoms in patients with Parkinson's disease (PD). Sleep can be disrupted by nocturnal motor and nonmotor symptoms and other comorbid sleep disorders. Rapid eye movement sleep behavior disorder (RBD) causes sleep-related injury, has important clinical implications as a harbinger of PD and predicts a progressive clinical phenotype. Read More

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Effects of work organization on the occurrence and resolution of sleep disturbances among night shift workers: a longitudinal observational study.

Sci Rep 2021 03 9;11(1):5499. Epub 2021 Mar 9.

Department of Occupational and Environmental Medicine, Ajou University School of Medicine, 164 World cup-ro, Yeongtong-gu, Suwon, 16499, South Korea.

This study aimed to investigate the association between work organization and the trajectories of insomnia patterns among night shift workers in a hospital. The health examination data of hospital workers, recorded from January 2014 to December 2018, were collected; 6765 records of 2615 night shift workers were included. Insomnia was defined as a score of ≥ 15 on the Insomnia Severity Index (ISI). Read More

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