510 results match your criteria Sleeplessness and Circadian Rhythm Disorder

Demographic, psychological, chronobiological, and work-related predictors of sleep disturbances during the COVID-19 lockdown in Italy.

Sci Rep 2021 06 1;11(1):11416. Epub 2021 Jun 1.

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio (Coppito 2), 67100, Coppito, AQ, Italy.

The first COVID-19 contagion wave caused unprecedented restraining measures worldwide. In Italy, a period of generalized lockdown involving home confinement of the entire population was imposed for almost two months (9 March-3 May 2020). The present is the most extensive investigation aimed to unravel the demographic, psychological, chronobiological, and work-related predictors of sleep disturbances throughout the pandemic emergency. Read More

View Article and Full-Text PDF

Work-Fitness Evaluation for Shift Work Disorder.

Tae-Won Jang

Int J Environ Res Public Health 2021 02 1;18(3). Epub 2021 Feb 1.

Department of Occupational and Environmental Medicine, Hanyang University, Seoul 04763, Korea.

Shift work disorder (SWD), which is characterized by insomnia and excessive sleepiness related with shift work, is one of the most common health problems in shift workers. Shift work disorder causes insomnia, fatigue, worse work performance, an increased likelihood of accidents, and a poor quality of life. In addition, SWD is associated with decreased productivity and increased economic costs. Read More

View Article and Full-Text PDF
February 2021

Sleep and COVID-19, the history of sleep, chronobiology and insomnia.

Dieter Riemann

J Sleep Res 2021 02;30(1):e13272

Department of Psychiatry and Psychotherapy, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany.

View Article and Full-Text PDF
February 2021

Prevalence and associated factors of circadian rhythm sleep-wake disorders and insomnia among visually impaired Japanese individuals.

BMC Public Health 2021 01 6;21(1):31. Epub 2021 Jan 6.

Department of Somnology, Tokyo Medical University, Tokyo, Japan.

Background: Although earlier studies have demonstrated that circadian rhythm sleep-wake disorders (CRSWD) are more prevalent in visually impaired individuals, the actual prevalence of CRSWD and insomnia among the visually impaired Japanese population remains unclear. The aim of this cross-sectional, telephone-based study was to estimate the prevalence of CRSWD and insomnia, and explore factors associated with CRSWD and insomnia among visually impaired Japanese individuals.

Methods: A nationwide telephone survey was conducted among visually-impaired individuals through local branches of the Japan Federation of the Blind. Read More

View Article and Full-Text PDF
January 2021

Sleep and Sex: A Review of the Interrelationship of Sleep and Sexuality Disorders in the Female Population, Through the Lens of Sleeping Beauty Syndrome.

Sex Med Rev 2021 Apr 3;9(2):221-229. Epub 2020 Oct 3.

Department of Obstetrics & Gynecology, University of California, Irvine, Orange, CA, USA. Electronic address:

Introduction: For many, sleep and sex are crucial for physical, emotional, and mental well-being. Poor sleep quality is linked to a myriad of ailments from coronary artery disease to major depressive disorder. Likewise, a decrease in the frequency of sexual activity is associated with a decrease in self-rated health status. Read More

View Article and Full-Text PDF

Telemedicine in Pediatric Sleep.

Shalini Paruthi

Sleep Med Clin 2020 Sep 3;15(3S):e1-e7. Epub 2020 Sep 3.

Sleep Medicine and Research Center, St. Luke's Hospital, 232 South Woods Mill Road, Chesterfield, MO 63017, USA; Pediatrics, Saint Louis University School of Medicine, St Louis, MO, USA. Electronic address:

Prior to the COVID-19 pandemic, few pediatric sleep medicine clinicians routinely engaged in telemedicine visits because thorough examinations were difficult to perform; there was lack of consistent reimbursement; and many clinicians were busy with their in-office practices. This article reviews how telemedicine has been explored in pediatric sleep medicine prior to the pandemic, current applications of telemedicine, challenges, and reimagining pediatric sleep within the realm of telemedicine. Read More

View Article and Full-Text PDF
September 2020

Effect of Suvorexant vs Placebo on Total Daytime Sleep Hours in Shift Workers: A Randomized Clinical Trial.

JAMA Netw Open 2020 06 1;3(6):e206614. Epub 2020 Jun 1.

Pulmonary, Critical Care, and Sleep Medicine Section, VA Palo Alto Health Care System, Palo Alto, California.

Importance: Many shift workers have difficulty sleeping during the daytime owing to an inappropriately timed circadian drive for wakefulness.

Objective: To determine whether a dual hypocretin receptor antagonist would enable shift workers to have more daytime sleep.

Design, Setting, And Participants: This double-blind, placebo-controlled randomized clinical trial included 2 weeks of baseline data and 3 weeks of intervention data, from March 2016 to December 2018. Read More

View Article and Full-Text PDF

Cannabidiol (CBD) and Δ-tetrahydrocannabinol (THC) for chronic insomnia disorder ('CANSLEEP' trial): protocol for a randomised, placebo-controlled, double-blinded, proof-of-concept trial.

BMJ Open 2020 05 18;10(5):e034421. Epub 2020 May 18.

Woolcock Institute of Medical Research, Centre for Sleep and Chronobiology, Sydney, New South Wales, Australia

Introduction: Insomnia is a highly prevalent and costly condition that is associated with increased health risks and healthcare utilisation. Anecdotally, cannabis use is frequently reported by consumers to promote sleep. However, there is limited research on the effects of cannabis on sleep and daytime function in people with insomnia disorder using objective measures. Read More

View Article and Full-Text PDF

Are cognitive variables that maintain insomnia also involved in shift work disorder?

Sleep Health 2020 06 9;6(3):399-406. Epub 2020 Apr 9.

École de psychologie, Université Laval, Québec, Québec, Canada; Laboratoire Psycho/Socio/Culturel du sommeil, Université Laval, Québec, Québec, Canada; Centre de recherche CERVO, Québec, Québec, Canada; Centre de recherche du CHU de Québec-Université Laval, Québec, Québec, Canada. Electronic address:

Objective: Shift Work Disorder (SWD) is explained mainly by a misalignment between the sleep schedule and the circadian rhythm. However, the possible role of cognitive variables in maintaining SWD remains unknown. Therefore, the objective of this study is to evaluate whether cognitive variables known to maintain insomnia in day workers might also be involved in perpetuating SWD. Read More

View Article and Full-Text PDF

Circadian rhythm in the assessment of postconcussion insomnia: a cross-sectional observational study.

CMAJ Open 2020 Jan-Mar;8(1):E142-E147. Epub 2020 Mar 10.

Department of Psychology (Zalai, Girard), Ryerson University, Toronto, Ont.; Oakville Centre for Cognitive Therapy (Zalai), Oakville, Ont.; Division of Neurosurgery and Injury Prevention (Cusimano), St. Michael's Hospital, University of Toronto; Department of Psychiatry (Shapiro), University of Toronto; Youthdale Child and Adolescent Sleep Centre (Shapiro), Toronto, Ont.

Background: Insomnia is a major predictor of adverse outcomes in mild traumatic brain injury (mTBI), including concussion; although insomnia symptoms may be due to various sleep disorders, those related to circadian rhythm sleep-wake disorders (CRSWDs) require specific assessment and treatment. The objective of the current study was to determine the prevalence of CRSWD in a sample of treatment-seeking people with chronic insomnia symptoms after an mTBI.

Methods: Participants aged 17-65 years who had experienced an mTBI and reported chronic insomnia were recruited from diverse community clinics in Ontario 3-24 months after their injury to participate in this cross-sectional observational study. Read More

View Article and Full-Text PDF
February 2021

[Differential diagnosis of insomnia from other comorbid primary sleep disorders].

Aten Primaria 2020 05 3;52(5):345-354. Epub 2020 Mar 3.

Neurofisiología Clínica, Unidad del sueño, Complejo Hospitalario de Navarra, Pamplona, Navarra, España.

The "insomnia complaint" currently has a very high prevalence in the medical consulting room. This assumes that any doctor must have some basic notions of how to approach it. But currently, there are certain aspects that hinder this approach, especially when the "insomnia disorder" needs to be ruled out from the rest of the primary sleep disorders. Read More

View Article and Full-Text PDF

Lemborexant: First Approval.

Lesley J Scott

Drugs 2020 Mar;80(4):425-432

Springer Nature, Mairangi Bay, Private Bag 65901, Auckland, 0754, New Zealand.

Lemborexant (DAYVIGO™) is an orally administered, dual orexin receptor (OXR) antagonist that exhibits reversible competitive antagonism at OXR1 and OXR2 (> affinity at OXR2) that was discovered and developed by Eisai Inc. for the treatment of adult patients with insomnia. In December 2019, lemborexant received its first approval (with final interim scheduling) in the USA for the treatment of adult patients with insomnia, characterized by difficulties with sleep onset and/or sleep maintenance. Read More

View Article and Full-Text PDF

Employees with shift work disorder experience excessive sleepiness also on non-work days: a cross-sectional survey linked to working hours register in Finnish hospitals.

Ind Health 2020 Aug 20;58(4):366-374. Epub 2020 Feb 20.

Finnish Institute of Occupational Health, Finland.

A considerable proportion of shift workers have work schedule-related insomnia and/or excessive sleepiness, a phenomenon described as shift work disorder (SWD). There is yet a lack of evidence on whether or not employees recover from symptoms of SWD between work shifts. We studied whether SWD and its subtypes are associated with insomnia and excessive sleepiness during weekly non-work days and with 24-h sleep time. Read More

View Article and Full-Text PDF

Stability of chronotype over a 7-year follow-up period and its association with severity of depressive and anxiety symptoms.

Depress Anxiety 2020 05 17;37(5):466-474. Epub 2020 Feb 17.

Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion regulation (ICPE), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Background: Chronotype is an individual's preferred timing of sleep and activity, and is often referred to as a later chronotype (or evening-type) or an earlier chronotype (or morning-type). Having an evening chronotype is associated with more severe depressive and anxiety symptoms. Based on these findings it is has been suggested that chronotype is a stable construct associated with vulnerability to develop depressive or anxiety disorders. Read More

View Article and Full-Text PDF

The correlation between the electroencephalographic spectral analysis and salivary cortisol rhythm in insomnia.

Sleep Breath 2020 Jun 16;24(2):661-667. Epub 2020 Feb 16.

Department of Neurology, Kayseri Training and Research Hospital, Şeker Mahallesi, Molu Yolu/Kocasinan, 38010, Kayseri, Turkey.

Objective: Insomnia is a common sleep disorder that affects many adults either transiently or chronically. This study aimed to establish whether there is a relationship between the electroencephalographic (EEG) spectral analysis and salivary cortisol levels in insomnia and compared to healthy controls.

Materials And Methods: This case-control study included 15 insomnia patients and 15 healthy control subjects. Read More

View Article and Full-Text PDF

Association between affective temperaments and mood features in bipolar disorder II: The role of insomnia and chronobiological rhythms desynchronization.

J Affect Disord 2020 04 22;266:263-272. Epub 2020 Jan 22.

Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine University of Freiburg, Germany.

Background: Bipolar disorders are complex disorders involving the interaction of multiple factors. Affective temperaments, insomnia, and chronobiological rhythms desynchronization may all contribute to bipolar disorder. Since there is a paucity of research examining this topic we aimed to study how they are interrelated and collectively associated with clinical features of bipolar disorder. Read More

View Article and Full-Text PDF

Relationship between Intrinsically Photosensitive Ganglion Cell Function and Circadian Regulation in Diabetic Retinopathy.

Sci Rep 2020 01 31;10(1):1560. Epub 2020 Jan 31.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.

Background: Intrinsically photosensitive retinal ganglion cells (ipRGCs) control non-visual light responses (e.g. pupillary light reflex and circadian entrainment). Read More

View Article and Full-Text PDF
January 2020

A composite measure of sleep health is associated with symptoms of depression among Japanese female hospital nurses.

Compr Psychiatry 2020 02 5;97:152151. Epub 2019 Dec 5.

Department of Psychiatry, Nihon University School of Medicine, Tokyo, Japan. Electronic address:

Background: Individual dimensions of sleep health, including satisfaction, sleepiness/alertness, timing, efficiency, and duration, are associated with depression. We investigated whether a composite sleep health score is associated with symptoms of depression among Japanese female hospital nurses.

Methods: Participants were nurses (n = 2482, all women, age 31. Read More

View Article and Full-Text PDF
February 2020

The epidemiology of sleep disorders in Israel: results from a population-wide study.

Sleep Med 2020 03 6;67:120-127. Epub 2019 Nov 6.

Institute of Research and Innovation, Maccabi Healthcare Services, Israel; The Sleep and Fatigue Institute, Assuta Medical Center, Israel; The Research Institute of Applied Chronobiology, The Academic College of Tel-Hai, Israel.

Background: Studies on the prevalence of sleep disorders have found great variability due to different data collection methods and case definitions. We aimed at assessing the prevalence of sleep disorders in a large, unselected population using validated clinical patient records. To the best of our knowledge, this is the first large clinically based study on sleep disorders. Read More

View Article and Full-Text PDF

Poor sleep quality associates with self-reported psychiatric and cardiometabolic symptoms independently of sleep timing patterns in a large sample of rural and urban workers.

J Sleep Res 2020 10 6;29(5):e12969. Epub 2020 Jan 6.

Laboratório de Cronobiologia e Sono, Hospital de Clínicas de Porto Alegre (HCPA)/Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.

Poor sleep associates with mental and cardiometabolic pathological outcomes. The participation of sleep timing features in the pathways by which this relationship occurs is not clear. This study aims to evaluate the interrelationship between sleep quality and self-reported psychiatric/cardiometabolic symptoms, considering mediation and moderation effects of sleep timing patterns, and urban versus rural work environment, respectively; and to verify the association between sleep quality and polymorphisms of AANAT, RORA and TIMELESS genes. Read More

View Article and Full-Text PDF
October 2020

Cognitive behavioural therapy interventions for insomnia among shift workers: RCT in an occupational health setting.

Int Arch Occup Environ Health 2020 07 18;93(5):535-550. Epub 2019 Dec 18.

Finnish Institute of Occupational Health (FIOH), Topeliuksenkatu 41 b, 00250, Helsinki, Finland.

Introduction: The aim of the study was to compare the effectiveness of cognitive behavioural therapy interventions for insomnia (CBT-I) to that of a sleep hygiene intervention in a randomized controlled design among shift workers. We also studied whether the features of shift work disorder (SWD) affected the results.

Methods: A total of 83 shift workers with insomnia disorder were partially randomized into a group-based CBT-I, self-help CBT-I, or sleep hygiene control intervention. Read More

View Article and Full-Text PDF

Sleep disorders in children with Angelman and Smith-Magenis syndromes: The assessment of potential causes of disrupted settling and night time waking.

Res Dev Disabil 2020 Feb 12;97:103555. Epub 2019 Dec 12.

Cerebra Centre for Neurodevelopmental Disorders, University of Birmingham, UK; School of Psychology, 52 Pritchatts Road, University of Birmingham, UK.

Background: Sleep problems are common in Smith-Magenis (SMS) and Angelman syndromes (AS). Effectiveness of interventions depends on appropriate assessment, complicated by compromised self-report and health and behaviour difficulties. Studying settling and waking in these syndromes could inform assessment. Read More

View Article and Full-Text PDF
February 2020

Somatic symptoms are associated with Insomnia disorder but not Obstructive Sleep Apnoea or Hypersomnolence in traumatic brain injury.

NeuroRehabilitation 2019 ;45(3):409-418

CIRUS, Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Sydney, NSW, Australia.

Background: Previous studies examining insomnia in populations with traumatic brain injury (TBI) have not distinguished between transient insomnia symptoms and insomnia disorder and associations have been confounded by other highly prevalent sleep disorders post-TBI.

Objective: To investigate the associations between affective symptoms and somatoform symptoms in patients with TBI and insomnia, sleep apnoea and hypersomnolence.

Methods: Twenty-four participants from a multidisciplinary brain injury rehabilitation service with TBI were assessed for insomnia disorder, using Diagnostic and Statistical Manual Fifth Edition (DSM-5) criteria. Read More

View Article and Full-Text PDF

Survey Results of a Pilot Sleep Study Near Atlanta International Airport.

Int J Environ Res Public Health 2019 11 6;16(22). Epub 2019 Nov 6.

Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

Aircraft noise can disturb the sleep of residents living near airports. To investigate potential effects of aircraft noise on sleep, recruitment surveys for a pilot field study were mailed to households around Atlanta International Airport. Survey items included questions about sleep quality, sleep disturbance by noise, noise annoyance, coping behaviors, and health. Read More

View Article and Full-Text PDF
November 2019

The role of sleep hygiene in the risk of Shift Work Disorder in nurses.

Sleep 2020 02;43(2)

School of Psychological Sciences and Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Melbourne, Victoria, Australia.

A high proportion (20%-30%) of shift workers experience Shift Work Disorder (SWD), characterized by chronic sleepiness and/or insomnia associated with work schedules. The reasons for individual variation in shift work tolerance are not well understood, however. The aim of this study was to identify individual factors that contribute to the risk of SWD. Read More

View Article and Full-Text PDF
February 2020

The chronotherapeutic treatment of bipolar disorders: A systematic review and practice recommendations from the ISBD task force on chronotherapy and chronobiology.

Bipolar Disord 2019 12 22;21(8):741-773. Epub 2019 Nov 22.

Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Aims: To systematically review the literature on the efficacy and tolerability of the major chronotherapeutic treatments of bipolar disorders (BD)-bright light therapy (LT), dark therapy (DT), treatments utilizing sleep deprivation (SD), melatonergic agonists (MA), interpersonal social rhythm therapy (IPSRT), and cognitive behavioral therapy adapted for BD (CBTI-BP)-and propose treatment recommendations based on a synthesis of the evidence.

Methods: PRISMA-based systematic review of the literature.

Results: The acute antidepressant (AD) efficacy of LT was supported by several open-label studies, three randomized controlled trials (RCTs), and one pseudorandomized controlled trial. Read More

View Article and Full-Text PDF
December 2019

Italian Association of Sleep Medicine (AIMS) position statement and guideline on the treatment of menopausal sleep disorders.

Maturitas 2019 Nov 15;129:30-39. Epub 2019 Aug 15.

Division of Obstetrics and Gynecology, Department of Clinical and Experimental Medicine, University of Pisa, Italy.

Insomnia, vasomotor symptoms (VMS) and depression often co-occur after the menopause, with consequent health problems and reductions in quality of life. The aim of this position statement is to provide evidence-based advice on the management of postmenopausal sleep disorders derived from a systematic review of the literature. The latter yielded results on VMS, insomnia, circadian rhythm disorders, obstructive sleep apnea (OSA) and restless leg syndrome (RLS). Read More

View Article and Full-Text PDF
November 2019

Sodium oxybate (Xyrem) treatment in severely sleep-deprived child with Epstein-Barr virus encephalitis with lesion of sleep-wake regulation system: a case report.

Sleep Med 2019 10 10;62:29-31. Epub 2019 Apr 10.

Danish Center of Sleep Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

We present the effect of exogenous sodium oxybate (GHB) in a severely tormented boy unable to sleep and unable to be anesthetized due to a lesion in the sleep initiation system involving the tracks between the ventrolateral preoptic nucleus and the reticular system. We bypassed the system by using sodium oxybate's effect on the cortical GHB and GABA receptors involved in the initiation and maintenance of sleep. Read More

View Article and Full-Text PDF
October 2019

Evening preference and poor sleep independently affect attentional-executive functions in patients with depression.

Psychiatry Res 2019 11 26;281:112533. Epub 2019 Aug 26.

Vitos Clinic for Psychiatry and Psychotherapy Giessen, Germany; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Germany.

Cognitive impairments are well documented in major depressive disorder (MDD), however, they cannot be fully explained by depressive symptom severity. We investigated how diurnal preference and sleep quality affect cognitive function in MDD. In 34 inpatients with current MDD and 29 healthy controls (HC), we obtained diurnal preference (Morningness-Eveningness Questionnaire, MEQ) and subjective sleep quality (Pittsburgh Sleep Quality Index, PSQI). Read More

View Article and Full-Text PDF
November 2019