12,390 results match your criteria Sleeplessness and Circadian Rhythm Disorder


Gene Expression Profiles of Tumor Necrosis Factor-α and Endothelin-1 in Obstructive Sleep Apnea.

ORL J Otorhinolaryngol Relat Spec 2018 Dec 11;81(1):16-23. Epub 2018 Dec 11.

Department of Otolaryngology and Head and Neck Surgery, Wakayama University Hospital, Wakayama, Japan.

Background/aims: The aim of this study was to observe the relationship between the gene expression profiles of tumor necrosis factor (TNF)-α and endothelin (EDN)-1 and obstructive sleep apnea (OSA).

Methods: A prospective, cross-sectional study performed at a tertiary-care academic center; 108 patients with snoring and day-time sleeplessness were included in this study carried out in the Otolaryngology Department. All patients were evaluated with 1-night polysomnography (PSG). Read More

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December 2018
6 Reads

Role of autonomic nervous system in atrial fibrillation.

Int J Cardiol 2018 Nov 18. Epub 2018 Nov 18.

Centre for Heart Rhythm Disorders (CHRD), South Australian Health and Medical Research Institute (SAHMRI), University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia.

Atrial fibrillation is the most common sustained arrhythmia and is associated with significant morbidity and mortality. The autonomic nervous system has a significant role in the milieu predisposing to the triggers, perpetuators and substrate for atrial fibrillation. It has direct electrophysiological effects and causes alterations in atrial structure. Read More

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November 2018
4 Reads

[Benzodiazepine cessation in ambulatory practice. A review].

Presse Med 2018 Oct 24;47(10):899-912. Epub 2018 Oct 24.

AP-HP, hôpital Fernand-Widal, département de psychiatrie et de médecine addictologique, 200, rue du Faubourg-Saint-Denis, 75010 Paris, France; Faculté de médecine Paris-Diderot et Inserm Umrs 1144, 75006 Paris, France. Electronic address:

Seven studies evaluated pharmacological treatments and 12 studies evaluated non-pharmacological interventions including Cognitive Behavioural Therapy (CBT), minimal interventions toward patients, pharmacists or physicians, or dedicated visits, in order to discontinue benzodiazepines treatments. Among pharmacological treatments, only melatonin was significantly efficacious in patients suffering from insomnia alone. BCT showed efficacy in increasing self-efficacy feeling toward BZD cessation and in patients with sleep disorders. Read More

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October 2018
7 Reads

[Should the duration of treatment be limited using benzodiazepines?]

Presse Med 2018 Oct 25;47(10):892-898. Epub 2018 Oct 25.

Université Bordeaux, Inserm, Bordeaux Population Health Research Center, Pharmaco epidemiology research team, UMR 1219, 33000 Bordeaux, France; Centre hospitalier Charles-Perrens, 33000 Bordeaux, France. Electronic address:

Benzodiazepines and Z-drugs have pharmacodynamic effects with tolerance that can occur quickly, after one week to one month of treatment and that concerns hypnotic and anxiolytic properties in particular. Old studies showed a real but poor short-term efficacy of benzodiazepines on anxiety and sleep disturbances. Long-term efficacy of benzodiazepines can be confused with the occurrence of rebound effect, discontinuation symptoms or relapse when the treatment is quitted; they contribute to an apparent efficacy, as well as the symptoms removal when treatment is re-initiated. Read More

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October 2018
3 Reads

[Benzodiazepine use and misuse in France].

Presse Med 2018 Oct 25;47(10):878-881. Epub 2018 Oct 25.

University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team Pharmacoepidemiology, UMR 1219, 33076 Bordeaux, France; DRUGS-SAFE National Platform of Pharmacoepidemiology, 33076 Bordeaux, France; University Hospital of Bordeaux, Clinical Pharmacology, 33076 Bordeaux, France.

Benzodiazepine use remains high in France in 2015, especially among the elders. However, encouraging trend is observed regarding hypnotic benzodiazepines initiation: between 2008 and 2015, incident use of hypnotics, including that of Z-drugs, decreased while incident use of anxiolytics remained stable. Most of new benzodiazepine users (86 %) had treatment duration that complies with guidelines. Read More

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October 2018

Aloysia citriodora Palau (lemon verbena) for insomnia patients: A randomized, double-blind, placebo-controlled clinical trial of efficacy and safety.

Phytother Res 2018 Nov 19. Epub 2018 Nov 19.

Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.

Aloysia citriodora (A. citriodora) has a long history of traditional use for sedation and treatment of insomnia in different societies. This study was carried out to assess the efficacy of A. Read More

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November 2018
3 Reads
2.400 Impact Factor

Sleep Quality and Sleep Duration with CKD are Associated with Progression to ESKD.

Clin J Am Soc Nephrol 2018 Dec 15;13(12):1825-1832. Epub 2018 Nov 15.

Yaizu City Hospital, Yaizu, Shizuoka, Japan.

Background And Objectives: Shorter or longer sleep duration and poor sleep quality are risk factors for numerous cardio-metabolic diseases, cardiovascular disease, and mortality in subjects with normal kidney function. The association of sleep duration and sleep quality with health outcomes in patients with CKD remains uncertain.

Design, Setting, Participants, & Measurements: A 4-year prospective cohort study in 17 nephrology centers in Japan, the CKD Japan Cohort (CKD-JAC) Study, assessed an association of self-reported sleep duration and sleep quality, on the basis of the Pittsburgh Sleep Quality Index (PSQI) questionnaire, with incidence of ESKD in 1601 patients with eGFR 10-59 ml/min per 1. Read More

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December 2018
4 Reads

Sleep Problems and Their Correlates in Children with Autism Spectrum Disorder: An Indian Study.

J Autism Dev Disord 2018 Nov 13. Epub 2018 Nov 13.

Maulana Azad Medical College, Bahadur Shah Zafar Marg, New delhi, 110002, India.

Sleep problems were studied in both typically developing (TD) children and those with autism spectrum disorder (ASD) using the Sleep Disturbance Scale for Children. Factors associated with these problems were also studied in children with ASD. Seventy-three children with ASD and their age and sex matched TD controls in age group of 3-12 years were enrolled in the study. Read More

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November 2018
1 Read

Cluster Analysis of Symptoms of Bangladeshi Women with Breast Cancer.

Indian J Palliat Care 2018 Oct-Dec;24(4):397-401

Department of Palliative Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.

Background: Breast cancer (BC) patients may experience multiple symptoms due to the disease itself, cancer treatment or combination of both.

Aim: The aim of the present study was to express multiple symptoms experienced by the patients with BC as clusters.

Methods: This was a retrospective study. Read More

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November 2018
3 Reads

Acupressure for insomnia: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2018 Nov;97(45):e13180

Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.

Background: Insomnia is a public sleep disorder defined as a deficiency of sleep quantity or quality. Acupressure is a low-cost treatment that has potential as an insomnia therapy.

Methods: Four databases will be searched from inception to date. Read More

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November 2018
1 Read

Shift work and sex are variants across Karolinska Sleep Questionnaire and the application of linking analysis as a step forward using Item Response Theory.

Chronobiol Int 2018 Nov 7:1-15. Epub 2018 Nov 7.

a School of Public Health , São Paulo University , Brazil.

The frequency of sleep disturbances is considerably higher in the night and shift workers and in females than in day workers and males, respectively. However, a subjective sleep scale must be invariant across these groups, independently of the level of their members on the scale. This study is aimed to test the invariance of the Karolinska Sleep Questionnaire's (KSQ) items by shift work and sex. Read More

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November 2018
4 Reads

[Good practices in prescribing benzodiazepines].

Presse Med 2018 Oct 29;47(10):872-877. Epub 2018 Oct 29.

Centre hospitalier universitaire, faculté de médecine, service de pharmacologie médicale et clinique, 31000 Toulouse, France. Electronic address:

Due to pharmacologic tolerance and dependence, benzodiazepines and z-drugs have to be used over short duration of treatment. Three pharmacokinetic characteristics should be taken into account by the prescriber: the galenic form, the plasma half-life, and the presence of an active metabolite. The patient and the prescriber should talk about possible adverse events and treatment discontinuation before treatment initiation. Read More

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October 2018

Contribution of individual COPD assessment test (CAT) items to CAT total score and effects of pulmonary rehabilitation on CAT scores.

Health Qual Life Outcomes 2018 Oct 30;16(1):205. Epub 2018 Oct 30.

Department of Research and Education, CIRO, Hornerheide 1, Horn, 6085, NM, The Netherlands.

Background: The COPD Assessment Test (CAT) contains eight items (cough, phlegm, chest tightness, breathlessness, limited activities, confidence leaving home, sleeplessness and energy). The current study aimed 1) to better understand the impact of the respiratory and non-respiratory CAT item scores on the CAT total score; and 2) to determine the impact of pulmonary rehabilitation (PR) on CAT items and CAT total score.

Methods: CAT total score of ≥10 or ≥ 18 points was used to classify patients as highly symptomatic, a decrease of 2 points was considered as clinically relevant improvement. Read More

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October 2018

Evaluation of the Sleep-Prolonging Effect of Lagenaria vulgaris and Cucurbita pepo Extracts on Pentobarbital-Induced Sleep and Possible Mechanisms of Action.

Medicina (Kaunas) 2018 Jul 31;54(4). Epub 2018 Jul 31.

Student Research Committee, Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad 91778-99191, Iran.

Sleeplessness is the most common sleep disorder. In this study, the hypnotic effect of macerated (HAME) and soxhlet (HASE) extract of (fruit and seed) and (fruit) were studied in mice. Extracts and fractions were administered intra-peritoneally (i. Read More

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July 2018
6 Reads

Assessing sleep quality of Lebanese high school students in relation to lifestyle: pilot study in Beirut.

East Mediterr Health J 2018 Oct 10;24(8):722-728. Epub 2018 Oct 10.

Laboratoire et clinique du sommeil, Hôpital Rivière-des-Prairies, Université de Montréal, Québec, Canada.

Background: Sleep problems in teenagers seriously disturb the active process of learning. Given the absence of sleep data from Lebanon, a study to determine sleep quality among adolescents is vital.

Aims: To understand sleep habits and patterns that affect sleep quality, and assess the amplitude of possible sleep problems in Lebanese adolescents, raising awareness of the effects of good sleep hygiene on general health in adolescents. Read More

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October 2018
4 Reads

Sleep disturbances and sleep disorders in adults living with chronic pain: a meta-analysis.

Sleep Med 2018 Dec 11;52:198-210. Epub 2018 Jun 11.

Faculty of Health & Medical Sciences, The University of Adelaide, South Australia, Australia; Psychology Department and Pain Management Unit, Central Adelaide Local Health Network, South Australia, Australia.

Objectives: Chronic pain, with or without an identified diagnosis or cause, is widespread and commonly associated with sleep disturbances. However, research has often used poor quality measures of sleep and focused on specific pain conditions, thereby limiting its reliability and applicability to the wider CP population. This study meta-analysed the findings from studies that used objective polysomnographic measures of sleep or examined diagnosed sleep disorders in people with CP. Read More

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December 2018
5 Reads

Associations of birth characteristics with perimenopausal disorders: a prospective cohort study.

J Dev Orig Health Dis 2018 Oct 9:1-7. Epub 2018 Oct 9.

1Department of Public Health Sciences,Karolinska Institutet,Stockholm,Sweden.

Perimenopausal disorders (PDs) are prevalent and importantly affect quality of life among middle-aged women. Yet, very little is known about the developmental origins of these disorders. The objective of this study was to investigate the associations of birth characteristics with PDs. Read More

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October 2018
1 Read

[The efficacy of cognitive behavioral therapy in insomnic patients with or without comorbidities: a pilot study].

Zhonghua Nei Ke Za Zhi 2018 Oct;57(10):731-737

Key Laboratory of Behavioral Science, Chinese Academy of Sciences, Institute of Psychology & Department of Psychology, University of Chinese Academy of Sciences, Beijing 100101, China.

To evaluate the effectiveness of cognitive behavior therapy for insomnia (CBT-i) in chronic insomnia patients in terms of the improvements of psychological and sleep diary parameters. Patients who met the diagnostic criteria of chronic insomnia, were divided into primary group or comorbid group. Both groups received standard CBT-i interventions. Read More

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October 2018
10 Reads

Understanding the Use of Acupuncture for Insomnia Among Cancer Survivors: A Qualitative Study.

J Altern Complement Med 2018 Sep/Oct;24(9-10):962-967

3 Memorial Sloan Kettering Cancer Center , New York, New York.

Objective: To understand cancer survivors' perceptions regarding the use of acupuncture for the treatment of cancer-related insomnia.

Design: Semistructured interviews with cancer survivors participating in a randomized controlled trial comparing the effectiveness of Cognitive Behavioral Therapy for Insomnia (CBT-I) and acupuncture for the treatment of insomnia. Interviews were conducted before randomization into either treatment option, and structured to elicit participants' experiences with insomnia as well as their beliefs and understanding surrounding acupuncture for the treatment of insomnia. Read More

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October 2018
13 Reads

Insomnia among Cancer Caregivers: A Proposal for Tailored Cognitive Behavioral Therapy.

J Psychother Integr 2018 Sep;28(3):275-291

Memorial Sloan Kettering Cancer Center, Department of Psychiatry and Behavioral Sciences.

Caregivers are relatives, friends, or partners who have a significant relationship with and provide assistance (i.e., physical, emotional) to a patient with often life-threatening, serious illnesses. Read More

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September 2018
1 Read

Reply to Hua Liu, HaiCun Shi and PingLei Pan: Coordinate based meta-analyses in a medium sized literature: Considerations, limitations and road ahead.

Sleep Med Rev 2018 12 26;42:236-238. Epub 2018 Aug 26.

Institute of Neuroscience and Medicine (INM-1; INM-7), Research Center Jülich, Jülich, Germany; Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

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December 2018
2 Reads
8.510 Impact Factor

A qualitative assessment of health behaviors and experiences during menopause: A cross-sectional, observational study.

Maturitas 2018 Oct 21;116:36-42. Epub 2018 Jul 21.

Pennington Biomedical Research Center, Baton Rouge, LA 70808, United States. Electronic address:

Objectives: A qualitative research study was performed to assess the health and lifestyle behaviors of middle-aged women during the menopause transition, as well as to inform the development of interventions designed to combat menopause symptoms and improve quality of life during and after menopause.

Study Design: Data were collected from 1611 women via a 21-item questionnaire distributed electronically. Only women who self-reported age ≥40 years and who were either peri-menopausal or post-menopausal were included in the analyses. Read More

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October 2018
1 Read

Medicalisation, pharmaceuticalisation, or both? Exploring the medical management of sleeplessness as insomnia.

Sociol Health Illn 2018 Sep 21. Epub 2018 Sep 21.

Criminology & Sociology, School of Law, Royal Holloway, Egham, UK.

In this paper we examine the medical management of sleeplessness as 'insomnia', through the eyes of general practitioners (GPs) and sleep experts in Britain. Three key themes were evident in the data. These related to (i) institutional issues around advocacy and training in sleep medicine (ii) conceptual issues in the diagnosis of insomnia (iii) and how these played out in terms of treatment issues. Read More

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September 2018
1 Read

Brain structural and functional alterations in insomnia disorder: More "homogeneous" research is needed.

Sleep Med Rev 2018 12 26;42:234-235. Epub 2018 Aug 26.

Department of Neurology, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, PR China; Department of Central Laboratory, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, PR China. Electronic address:

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December 2018
1 Read

Effects of Pain and Sleep Quality on Falls Among Nursing Home Residents in Turkey.

Res Gerontol Nurs 2018 09;11(5):257-264

The current study was conducted to detect the incidence of falls among individuals in nursing homes, as well as the impact of pain and sleep quality on falls. The sample for this cross-sectional study comprised 291 older adults. Pain was assessed using the Geriatric Pain Measure and insomnia was assessed using the Insomnia Severity Index. Read More

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September 2018
5 Reads

Targeted Neurotransmitters Profiling Identifies Metabolic Signatures in Rat Brain by LC-MS/MS: Application in Insomnia, Depression and Alzheimer's Disease.

Molecules 2018 Sep 17;23(9). Epub 2018 Sep 17.

School of Pharmacy, National and Local Joint Engineering Laboratory for Key Technology of Chinese Material Medica Quality Control, Shenyang Pharmaceutical University, 103 Wenhua Rd, Shenyang 110016, China.

Epidemiological, cross-sectional, and prospective studies have suggested that insomnia, Alzheimer's disease (AD) and depression are mutually interacting conditions and frequently co-occur. The monoamine and amino acid neurotransmitter systems in central nervous system were involved in the examination of neurobiological processes of this symptom complex. However, few studies have reported systematic and contrastive discussion of different neurotransmitters (NTs) changing in these neurological diseases. Read More

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September 2018

Impact of migraine on the clinical presentation of insomnia: a population-based study.

J Headache Pain 2018 Sep 14;19(1):86. Epub 2018 Sep 14.

Department of Neurology, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemoon-gu, Seoul, Republic of Korea.

Background: Insomnia and migraine are closely related; insomnia aggravates migraine symptoms. This study was conducted to investigate the impact of migraine on the clinical presentation of insomnia symptoms.

Methods: The data of the Korean Headache-Sleep Study (KHSS) were used in the present study. Read More

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September 2018
10 Reads

Sleep onset latency is related with reduced bone mineral density in elderly people with insomnia: a retrospective study.

Clin Interv Aging 2018 30;13:1525-1530. Epub 2018 Aug 30.

Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China,

Purpose: Inconsistent outcome about association between insufficient sleep and bone mineral density (BMD) has been reported. The present study aimed to determine whether BMD was associated with score of Pittsburgh Sleep Quality Index (PSQI).

Methods: A total of 410 patients (mean age 81. Read More

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November 2018
5 Reads

Cognitive behavioral therapy for insomnia combined with eszopiclone for the treatment of sleep disorder patients transferred out of the intensive care unit: A single-centred retrospective observational study.

Medicine (Baltimore) 2018 Sep;97(37):e12383

Department of Medical Psychosomatic, Hangzhou Seventh People's Hospital.

Patients transferred out of the intensive care unit (ICU) are always impaired by sleep disorders. Cognitive behavioral therapy for insomnia (CBT-I) and eszopiclone are 2 commonly prescribed strategies for insomnia. In the current study, the effect of the combined application of the 2 methods on sleep disorders in ICU transferred out patients was assessed. Read More

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September 2018
1 Read

Oriental herbal medicine for insomnia in the elderly with hypertension: A systematic review protocol.

Medicine (Baltimore) 2018 Sep;97(36):e12200

Department of Neuropsychiatry of Korean Medicine, Pohang Korean Medicine Hospital, Daegu Haany University, Pohang-si, Gyeongsangbuk-do, Republic of Korea.

Background: Hypertension and insomnia are common diseases in the elderly. Oriental herbal medicine has been widely used in East Asia, and it has been considered as a promising alternative to conventional pharmacotherapy because of its efficacy in geriatrics. Moreover, since oriental herbal medicine acts on multiple targets, it may affect both hypertension and insomnia at the same time, which can reduce the risk of polypharmacy in this population. Read More

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September 2018
10 Reads

Evidence-based psychological therapies for insomnia.

Lancet 2018 09;392(10149):735

Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK.

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September 2018
1 Read

Making sleep easier: pharmacological interventions for insomnia.

Expert Opin Pharmacother 2018 Sep 3;19(13):1465-1473. Epub 2018 Sep 3.

a Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine , University of Freiburg , Freiburg im Breisgau , Germany.

Introduction: The disorder insomnia represents a relevant and frequent condition in clinical care. Cognitive behavioral therapy of insomnia (CBT-I) is regarded as first line treatment. Pharmacotherapy can be considered if CBT-I is not available or effective. Read More

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September 2018
11 Reads

Prevalence and socio-economic correlates of insomnia among older people in Anhui, China.

Australas J Ageing 2018 Sep;37(3):E91-E96

School of Health Service Management, Anhui Medical University, Hefei, China.

Objective: To measure the prevalence of insomnia and identify the socio-economic correlates of insomnia among older people of Anhui Province of China.

Methods: A cross-sectional study was conducted among 3045 randomly selected consenting residents aged 60 and older from Anhui Province during 2013. Insomnia was assessed using the Athens Insomnia Scale (AIS). Read More

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September 2018

Double-blind randomized placebo-controlled trial on efficacy and safety of Lactuca sativa L. seeds on pregnancy-related insomnia.

J Ethnopharmacol 2018 Dec 30;227:176-180. Epub 2018 Aug 30.

Maternal-Fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Ethnopharmacological Relevance: There is limited evidence about the role of herbal and traditional medicine in pregnancy-related insomnia. Extant documents on traditional Persian medicine refer to many plants which could induce sleep and which were used by pregnant women. In Iran, local herbal shops continue to provide these herbs to pregnant women to treat insomnia. Read More

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December 2018
13 Reads

An effectiveness comparison of acupuncture treatments for insomnia disorder: A bayesian network meta-analysis protocol.

Medicine (Baltimore) 2018 Aug;97(35):e12060

Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Clinical College of Guangzhou University of Chinese Medicine.

Background: Acupuncture (ACU) is used frequently in the management of insomnia disorder in China. Whereas there is variability in practice regarding the selection of ACU treatments, most choices are made based on personal experience or preference of clinician. This study uses network meta-analysis to compare the effectiveness of different forms of ACU for insomnia and assesses the evidence with the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. Read More

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August 2018
8 Reads

Magnetic resonance study on the brain structure and resting-state brain functional connectivity in primary insomnia patients.

Medicine (Baltimore) 2018 Aug;97(34):e11944

Department of Radiology, People's Hospital of Zhengzhou University and Henan Provincial People's Hospital, Zhengzhou, Henan, China.

The aim of the study was to study the changes in brain structure and functional connectivity in primary insomnia (PI) patients, as well as to explore the biological characteristics of PI abnormality and the pathophysiological mechanism underlying the brain structure and the abnormal functional connectivity under depression.Voxel-based morphometry (VBM) technique and resting-state functional connectivity magnetic resonance imaging (rs-fcMRI) techniques were used to investigate the brain structure and rs-fc in PI and light-moderate primary insomnia with depression (PID) patients; healthy individuals were used as the normal control (NC) group. The differences between the 3 groups, the correlation between the brain network connection of the anterior cingulate cortex (ACC), and clinical information were compared. Read More

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August 2018
6 Reads

Toll-like Receptor 4 Pathway Polymorphisms Interact with Pollution to Influence Asthma Diagnosis and Severity.

Sci Rep 2018 Aug 23;8(1):12713. Epub 2018 Aug 23.

Clinical Research Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, 27709, United States.

Asthma is a common chronic lung disease, the incidence and severity of which may be influenced by gene-environment interactions. Our objective was to examine associations between single nucleotide polymorphisms (SNPs) and combinations of SNPs in the toll-like receptor 4 (TLR4) pathway, residential distance to roadway as a proxy for traffic-related air pollution exposure, and asthma diagnosis and exacerbations. We obtained individual-level data on genotype, residential address, and asthma diagnosis and exacerbations from the Environmental Polymorphisms Registry. Read More

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August 2018
61 Reads

[Clinical, neuroimaging and genetic features of two Chinese families with fatal familial insomnia].

Zhonghua Yi Xue Za Zhi 2018 Aug;98(31):2501-2504

Department of Neurology, the Navy General Hospital, Beijing 100048, China.

To examine clinical, neuroimaging and genetic features of two Chinese families with fatal familial insomnia (FFI). The clinical data, including case history, physical examination, biochemical analysis of blood and neuroimaging of two pedigrees with FFI who admitted to the Navy General Hospital in 2014 and 2017 were collected. The D178N prion protein (PRNP) mutation were determined by DNA sequencing among the proband and family members. Read More

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August 2018
1 Read

Effects of a 10-week functional training programme on pain, mood state, depression, and sleep in healthy older adults.

Psychogeriatrics 2018 Jul;18(4):292-298

Department of Corporal Expression, University of Jaen, Jaen, Spain.

Background: The purpose of this study was to analyze the effects of a 10-week functional training (FT) programme on pain, mood state, sleep, and depression in healthy older adults.

Method: A group of 38 older adults (32 women, 6 men) voluntarily participated in this study. Participants were randomly assigned to either the experimental group (n = 20; age: 75. Read More

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July 2018
1 Read

Delirium associated with only one dose of zopiclone in an older adult.

Psychogeriatrics 2018 Jul;18(4):321-323

Unit for Aging Brain and Dementia, Department of Geriatric Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.

Both insomnia and its treatment can lead to the development of delirium in older adults. In the present case, delirium occurred after a single dose of zopiclone was given for insomnia treatment in an 84-year-old patient. Considering the case, patients and caregivers should be informed about the rare complication when zopiclone is prescribed. Read More

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July 2018
2 Reads

What should we tell our worried patients with insomnia about blood pressure?

Sleep Med Rev 2018 10 7;41:1-2. Epub 2018 Jul 7.

Sleep Research & Treatment Center, Penn State College of Medicine, Penn State Health Milton S. Hershey Medical Center, 500 University Dr. H073, Hershey, PA, 17033, USA. Electronic address:

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October 2018
1 Read

Chronic hypnotic use at 10 years-does the brand matter?

Eur J Clin Pharmacol 2018 Dec 8;74(12):1623-1631. Epub 2018 Aug 8.

Department of Family Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Purpose: Chronic use of sedative-hypnotics is very common, although not guideline-endorsed. The incidence among new users is not well studied, and there are currently no recommendations favoring any specific agent. We quantified the risk for chronic use in first-time hypnotic users, and the association of the initial choice of hypnotic with later usage patterns. Read More

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December 2018
4 Reads

Effect of Acupuncture Cooperated with Low-frequency Repetitive Transcranial Magnetic Stimulation on Chronic Insomnia: A Randomized Clinical Trial.

Curr Med Sci 2018 Jun 22;38(3):491-498. Epub 2018 Jun 22.

Department of Physical Medicine and Rehabilitation, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Wuhan, 430015, China.

The effect of acupuncture cooperated with low-frequency repetitive transcranial magnetic stimulation (rTMS) on chronic insomnia was explored. Seventy-eight patients with chronic insomnia were randomly allocated into two groups: treatment group and control group. In the treatment group, the patients received acupuncture combined with rTMS treatment, and those in the control group were given acupuncture cooperated with sham rTMS treatment, 3 days per week for 4 weeks. Read More

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June 2018
1 Read

Urinary Mercury Levels Among Workers in E-waste Shops in Nakhon Si Thammarat Province, Thailand.

Authors:
Somsiri Decharat

J Prev Med Public Health 2018 Jul 19;51(4):196-204. Epub 2018 Jun 19.

Department of Occupational Health and Safety, Faculty of Health and Sports Science, Thaksin University, Phatthalung, Thailand.

Objectives: To determine urinary mercury levels in e-waste workers in Southern Thailand and the airborne mercury levels in the e-waste shops where they worked, to describe the associations between urinary and airborne mercury levels, and to evaluate the prevalence of mercury exposure-related health effects among e-waste workers.

Methods: A cross-sectional study was conducted by interviewing 79 workers in 25 e-waste shops who lived in Nakhon Si Thammarat Province, Thailand. Information on general and occupational characteristics, personal protective equipment use, and personal hygiene was collected by questionnaire. Read More

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Romaine Lettuce/Skullcap Mixture Improves Sleep Behavior in Vertebrate Models.

Biol Pharm Bull 2018 ;41(8):1269-1276

Department of Food Science and Technology, Seoul Women's University.

The aim of this study is to investigate the effects of romaine lettuce leaves extract (RE), skullcap root extract (SE) and their mixture on sleep behaviors in vertebrate models. HPLC analysis showed that RE contains lactucopicrin (0.02±0. Read More

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October 2018
15 Reads

Insomnia in Elderly Patients: Recommendations for Pharmacological Management.

Drugs Aging 2018 Sep;35(9):791-817

Division of Sleep Medicine, Department of Psychiatry and Behavioral Sciences, Stanford Outpatient Medical Center, Stanford University, 450 Broadway St. Pavilion C 2nd Floor MC 5704, Redwood City, CA, 94063, USA.

Chronic insomnia affects 57% of the elderly in the United States, with impairment of quality of life, function, and health. Chronic insomnia burdens society with billions of dollars in direct and indirect costs of care. The main modalities in the treatment of insomnia in the elderly are psychological/behavioral therapies, pharmacological treatment, or a combination of both. Read More

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September 2018
1 Read

SZSJ protects against insomnia by a decrease in ADMA level and an improvement in DDAH production in sleep-deprived rats.

Life Sci 2018 Sep 23;209:97-102. Epub 2018 Jul 23.

Hunan Province University Key Laboratory for Agricultural Biochemistry and Biotransformation, Hunan Agricultural University, China; Hunan Co-Innovation Center for Utilization of Botanical Functional Ingredients, China.

Aims: Recent investigations have shown that dimethylarginine dimethylaminohydrolase (DDAH) may be related to sleep disorder. The present study was conducted to test the hypnotic effect of jujubosides from Semen Ziziphi Spinosae (SZSJ) on sleep deprivation and the mechanisms involved.

Materials And Methods: Forty rats were randomly divided into 4 groups (n = 10): two groups of sleep-deprived rats treated with SZSJ (10 or 30 mg/kg per day), sleep-deprived rats group, and control group. Read More

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September 2018

The association of sleep with neighborhood physical and social environment.

Public Health 2018 Sep 21;162:126-134. Epub 2018 Jul 21.

Department of Social Sciences and Health Policy Division of Public Health Sciences, Wake Forest University School of Medicine Winston-Salem, NC, United States.

Objectives: While sleep is critical for good health, it remains a major public health concern because millions of individuals do not obtain a sufficient amount of sleep at night to reap proper health benefits. When examining factors that contribute to deleterious sleep outcomes, few researchers to date have examined the physical and social environments together.

Study Design: This article is an analytical essay. Read More

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September 2018