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Fortschr Neurol Psychiatr 2019 Apr 18;87(4):259-270. Epub 2019 Apr 18.

Long-term prescriptions of benzodiazepines are made mainly to elderly and female patients. Withdrawal treatments should be carried out gradually over a period of several weeks. Sleep and depressive disorders during benzodiazepine withdrawal can best be treated with sedating antidepressants. Read More

Ecotoxicol Environ Saf 2019 Apr 15;178:94-104. Epub 2019 Apr 15.

State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 211198, PR China; School of Life Science and Technology, China Pharmaceutical University, Nanjing, 211198, PR China; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210023, PR China. Electronic address:

Light is involved in many critical physiological or biochemical processes of human beings, such as visual sensing and the production of vitamin D. Recent studies have showed that the lights of different wavelengths have a profound influence in life activities. For example, blue light promotes alertness, whereas green light (GL) induces sleep in mice. Read More

Brain Res 2019 Apr 15. Epub 2019 Apr 15.

Student's Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran; NeuroImaging Network (NIN), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Electronic address:

Narcolepsy (NA) is a primary sleep disorder characterized by loss of hypocretinergic/orexinergic neurons. NA is associated with an increased risk for metabolic disorders such as diabetes mellitus (DM). Proposed mechanisms for this association are alterations in food intake, disruption of energy balance, glucose tolerance, and insulin sensitivity, as well as inflammation and genetic factors. Read More

PLoS One 2019 18;14(4):e0215530. Epub 2019 Apr 18.

Department of Epidemiology and Biostatistics, School of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of Congo.

Background: The ultimate goal of asthma treatment is long-term control. Uncontrolled asthma is a major public health problem worldwide, but there is a lack of data on asthma control and its causes in the Democratic Republic of Congo (DRC).

Objective: To determine the socio-demographic, environmental, clinical, and biological factors and comorbidities associated with uncontrolled adult asthma in Kinshasa, DRC. Read More

PLoS One 2019 18;14(4):e0215374. Epub 2019 Apr 18.

Department of Pain, Lanzhou University Second Hospital, Lanzhou, Gansu Province, People's Republic of China.

This study is to identify the risk factors for postoperative delirium (PODE) in patients undergoing microvascular decompression (MVD) for the treatment of primary cranial nerve disorders. We retrospectively reviewed the data of 912 patients (354 men, 558 women) with primary cranial nerve disorders (trigeminal neuralgia, 602 patients; hemifacial spasm, 296 patients; glossopharyngeal neuralgia, 14 patients) who underwent MVD in the Neurosurgery Department of Lanzhou University Second Hospital between July 2007 and June 2018. Potential risk factors for PODE were identified using univariate and multivariate stepwise logistic regression analysis. Read More

J Clin Endocrinol Metab 2019 Apr 18. Epub 2019 Apr 18.

Dutch Growth Research Foundation, Rotterdam, The Netherlands.

Context: Sleep-related breathing disorders (SRBD) are common in people with Prader-Willi syndrome (PWS). Young adults with PWS benefit from GH continuation after adult height by maintaining the improved body composition obtained during childhood. There are, however, no studies about the effects of GH on SRBD in young adults with PWS who were treated with GH during childhood. Read More

J Neurol 2019 Apr 17. Epub 2019 Apr 17.

King's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Basic and Clinical Neurosciences, De Crespigny Park, London, SE5 8AF, UK.

Objective: To identify associated (non-)motor profiles of Parkinson's disease (PD) patients with hyperhidrosis as a dominant problem.

Methods: This is a cross-sectional, exploratory, analysis of participants enrolled in the Non-motor Longitudinal International Study (NILS; UKCRN No: 10084) at the Parkinson's Centre at King's College Hospital (London, UK). Hyperhidrosis scores (yes/no) on question 28 of the Non-Motor Symptom Questionnaire were used to classify patients with normal sweat function (n = 172) and excessive sweating (n = 56) (Analysis 1; n = 228). Read More

Eur Arch Otorhinolaryngol 2019 Apr 17. Epub 2019 Apr 17.

Department of Otorhinolaryngology Head and Neck Surgery, Police General Hospital, 492/1 Rama 1 Road, Patumwan, Bangkok, Thailand.

Objective: To conduct a systematic review and meta-analysis in children with syndromic craniosynostosis, to evaluate the effect of adenotonsillectomy for the treatment of obstructive sleep apnea (OSA).

Study Design: A systematic review and meta-analysis.

Search Methods: Data sources: a comprehensive search of PubMed, SCOPUS, Ovid Medline, and Web of science databases was performed through June 22nd, 2018. Read More

Open Med (Wars) 2019 4;14:307-316. Epub 2019 Apr 4.

Department of Neurology, Faculty of Medicine, University of Debrecen, Debrecen, Egyetem tér 1, H-4032, Hungary.

Background: Behavioural and psychological symptoms in dementia (BPSD) form an important sub-syndrome of dementia. We assessed the frequency and severity of BPSD in a random sample of Hungarian treatment-naïve dementia patients. Furthermore, we examined the relationship between cognitive symptoms and BPSD and the pattern of BPSD in specific types of dementias. Read More

J Thorac Dis 2019 Mar;11(Suppl 3):S480-S482

CNR, Institute of Biomedicine and Molecular Immunology, Palermo, Italy.

Ger Med Sci 2019 22;17:Doc02. Epub 2019 Feb 22.

Department of Internal Medicine II, University Hospital Ulm, Germany.

The current gold standard for assessment of most sleep disorders is the in-laboratory polysomnography (PSG). This approach produces high costs and inconveniences for the patients. An accessible and simple preliminary screening method to diagnose the most common sleep disorders and to decide whether a PSG is necessary or not is therefore desirable. Read More

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Sleep Medicine and Sleep Disorders Center, Aichi Medical University Hospital, Japan.

Objective The association between narcolepsy and rapid eye movement (REM)-related obstructive sleep apnea (OSA) has not been reported. This study aimed to examine the prevalence of REM-related OSA in narcolepsy patients. Methods From January 2013 to April 2018, 141 adult patients were diagnosed with narcolepsy using nocturnal polysomnography and the multiple sleep latency test. Read More

Rev Assoc Med Bras (1992) 2019 Mar 11;65(3):375-383. Epub 2019 Apr 11.

Department of Psychobiology, Federal University of Sao Paulo, Sao Paulo, SP, Brasil.

Objective: This study aims to evaluate the sleep of subjects with polycystic ovary syndrome (PCOS), with and without hyperandrogenism, in comparison with a healthy control group and examine the effects of hyperandrogenism and obesity on sleep parameters.

Methods: A total of 44 volunteers were recruited to participate in the study. Clinical, biochemical and polysomnographic parameters were used to diagnose PCOS and hyperandrogenism. Read More

J Med Internet Res 2019 Apr 17;21(4):e11029. Epub 2019 Apr 17.

Korea University College of Medicine, Department of Psychiatry, Seoul, Republic of Korea.

Background: Virtually, all organisms on Earth have their own circadian rhythm, and humans are no exception. Circadian rhythms are associated with various human states, especially mood disorders, and disturbance of the circadian rhythm is known to be very closely related. Attempts have also been made to derive clinical implications associated with mood disorders using the vast amounts of digital log that is acquired by digital technologies develop and using computational analysis techniques. Read More

Qual Life Res 2019 Apr 16. Epub 2019 Apr 16.

Department of Psychology, The Education University of Hong Kong, Tai Po, Hong Kong.

Purpose: For many individuals with mental disorders, stigma may represent a potent stressor that can disrupt sleep and impair health and quality of life. In this study, we tested a stigma model of sleep health, hypothesizing that public stigma (as indicated by experienced discrimination) and internalized stigma (as indicated by self-stigma content and process) would affect sleep and, in turn, health-related quality of life (HRQoL) among individuals with mental disorders.

Methods: A total of 282 individuals with mental disorders from Hong Kong, China, completed questionnaire measures of experienced discrimination, self-stigma content and process, sleep disturbance, and physical and mental HRQoL. Read More

Clin Ter 2019 Mar-Apr;170(2):e110-e123

Department of Neurology and Psychiatry University of Rome Sapienza.

Aims: The aim of the study was to investigate the frequency, type, causes and consequences of violence and aggression experienced by Emergency Department workers during their interactions with patient, their relatives or companions and whether the phenomenon of violence at work is a specific risk factor predicting stress and possible stress related pathologies in emergency health workers. The study proposes a model of effective intervention for the prevention and management of violence and stress.

Methods: A cross-sectional retrospective study was performed with a sample of 323 healthcare workers at Department of Emergency and Acceptance of Level II and the Psychiatric Services of Diagnosis and Care of the University Hospital Policlinico Umberto I, in Rome, Italy, between June 2016 and February 2017. Read More

Nat Commun 2019 Apr 16;10(1):1763. Epub 2019 Apr 16.

Biological and Soft Systems Sector, Cavendish Laboratory, University of Cambridge, Cambridge, CB3 0HE, UK.

Personalized approaches for systematically assessing ciliary beat dynamics and for drug testing would improve the challenging task of diagnosing and treating respiratory disorders. In this pilot study, we show how multiscale differential dynamic microscopy (multi-DDM) can be used to characterize collective ciliary beating in a non-biased automated manner. We use multi-DDM to assess the efficacy of different CFTR-modulating drugs in human airway epithelial cells derived from subjects with cystic fibrosis (ΔF508/ΔF508 and ∆F508/-) based on ciliary beat frequency and coordination. Read More

Eur Addict Res 2019 Apr 16:1-12. Epub 2019 Apr 16.

Department of Psychiatry, Addis Ababa University, College of Health Sciences, School of Medicine Addis Ababa, Addis Ababa, Ethiopia.

Background: Problematic khat use, not khat use per se, is a public health and social concern for the public, researchers, and policy makers. However, the construct problematic khat use is not well-established and not fully recognized in the modern definition of substance use disorders including Diagnostic Statistic Manual (DSM-5) and international classification of diseases (ICD-10), although DSM-5 included it in the "stimulant use disorder" category. Existing scoping reviews have focused on khat use, which could not allow the differentiation of khat use from problematic khat use. Read More

PLoS Genet 2019 Apr 16;15(4):e1007739. Epub 2019 Apr 16.

Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, United States of America.

Sleep disordered breathing (SDB)-related overnight hypoxemia is associated with cardiometabolic disease and other comorbidities. Understanding the genetic bases for variations in nocturnal hypoxemia may help understand mechanisms influencing oxygenation and SDB-related mortality. We conducted genome-wide association tests across 10 cohorts and 4 populations to identify genetic variants associated with three correlated measures of overnight oxyhemoglobin saturation: average and minimum oxyhemoglobin saturation during sleep and the percent of sleep with oxyhemoglobin saturation under 90%. Read More

Med Lav 2019 Apr 19;110(2):115-129. Epub 2019 Apr 19.

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Background: Workplace hazards are a significant source of health impairment for workers and of financial losses for firms. EU directives on workers' health and safety standards significantly contributed to reduce reported occupational injuries, yet the incidence and prevalence of work-related mental illness is still very high.

Objectives: We investigated the association between work-related hazards and individuals' perceived mental health. Read More

Zhongguo Zhong Yao Za Zhi 2019 Mar;44(6):1069-1074

Traditional Chinese Medicine Hospital of Huairou District Beijing 101400,China.

The efficacy and safety of traditional Chinese medicine and acupuncture in the treatment of kidney-deficiency and bloodstasis perimenopausal sleep disorders were evaluated. A total of 67 subjects who completed the study were randomly divided into two groups. The traditional Chinese medicine group was orally given Bushen Huoxue Anshen Fang,and the acupuncture group was given acupuncture treatment. Read More

Sultan Qaboos Univ Med J 2018 Nov 28;18(4):e455-e460. Epub 2019 Mar 28.

Department of Surgery, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman.

Objectives: This study aimed to evaluate cognitive and behavioural changes among 9-14-year-old Omani children with obstructive sleep apnoea (OSA) after an adenotonsillectomy (AT).

Methods: This naturalistic observational study was conducted at the Sultan Qaboos University Hospital, Muscat, Oman, between January 2012 and December 2014. Omani children with adenotonsillar hypertrophy (ATH) underwent overnight polysomnography and those with confirmed OSA were scheduled for an AT. Read More

Lancet Respir Med 2019 Apr 12. Epub 2019 Apr 12.

Centro de Investigación Biomédica en Red Enfermedades Respiratorias, Madrid, Spain; Paediatric Department, Institut Respiratori, Hospital Clinic Barcelona, Barcelona, Spain; Respiratory Department, University of Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.

Obstructive sleep apnoea (OSA) is a heterogeneous and complex disease; however, diagnosis and management still rely on a simple set of tools and few therapeutic options. Precision medicine has emerged as the next goal for clinical practice, with the objective being to offer individually tailored treatments. Ways of implementing precision medicine in clinical practice have emerged for various respiratory disorders, and such an approach could also be readily exported to OSA. Read More

J Craniofac Surg 2019 Apr 10. Epub 2019 Apr 10.

Department of Otolaryngology, National Center for Child Health and Development, Tokyo, Japan.

Background: Sleep disordered breathing (SDB) is defined as a series of disorders including snoring, obstructive sleep apnea, and hypopnea. Few studies investigated the incidence of SDB following primary palatoplasty with objective testing. The aims of this study were to elucidate the prevalence and degree of SDB approximately 1 week following primary palatoplasty with objective testing and to clarify the risk factors. Read More

Crit Care Med 2019 Apr 15. Epub 2019 Apr 15.

Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Medicine, Harborview Medical Center, University of Washington, Seattle, WA.

Objectives: Family members of ICU survivors report long-term psychologic symptoms of posttraumatic stress disorder. We describe patient- and family-member risk factors for posttraumatic stress disorder symptoms among family members of survivors of acute respiratory distress syndrome.

Design: Prospective cohort study of family members of acute respiratory distress syndrome survivors. Read More

J Med Internet Res 2019 Apr 15;21(4):e11756. Epub 2019 Apr 15.

Department of Anesthesiology and Pain Medicine, School of Medicine, University of Washington, Seattle, WA, United States.

Background: Delivery of behavioral health interventions on the internet offers many benefits, including accessibility, cost-effectiveness, convenience, and anonymity. In recent years, an increased number of internet interventions have been developed, targeting a range of conditions and behaviors, including depression, pain, anxiety, sleep disturbance, and eating disorders. Human support (coaching) is a common component of internet interventions that is intended to boost engagement; however, little is known about how participants interact with coaches and how this may relate to their experience with the intervention. Read More

Front Pediatr 2019 29;7:111. Epub 2019 Mar 29.

Division of Neonatology, Department of Pediatrics, University of Kentucky, Lexington, KY, United States.

Neonatal abstinence syndrome (NAS) refers to a constellation of signs occurring in newborn infants who were exposed to opioids or opiates . These manifestations include poor feeding, gastrointestinal disorders, abnormal sleep patterns, and neurological signs such as jitteriness, tremors, and seizures (1, 2). Myoclonus, jitteriness, and tremors often may be interpreted as seizures and therefore treated as epileptic seizures. Read More

Front Neurol 2019 21;10:249. Epub 2019 Mar 21.

Department of Psychiatry and Psychotherapy, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.

J Obstet Gynaecol 2019 Apr 15:1-6. Epub 2019 Apr 15.

b Department of Biostatistics, Faculty of Medicine , Hitit University , Çorum , Turkey.

The purpose of this study was to compare patients who were diagnosed with hyperemesis gravidarum (HG) with the control group by identifying anxiety, depression, sleep disorder levels and the relationship between them. This study involved 98 first-trimester pregnant women (46 HG patients and 52 control group patients) who applied to the Hitit University Medicine Faculty Obstetrics and Gynecology clinic. Statistically significant differences were found between HG patients and the control group according to the Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) scores (p < . Read More

Aging Ment Health 2019 Apr 14:1-8. Epub 2019 Apr 14.

a Faculty of Psychology, Southwest University , Chongqing , China.

Objectives: In the present study, we explored the age differences of mood states and memory performance between younger and older adults after one night of sleep disruption.

Method: Twenty-nine younger adults and 30 older adults completed mood states assessments and memory tasks before and after sleep disruption. Participants' sleep was disrupted by periodical phone calls once per hour. Read More

J Sleep Res 2019 Apr 14:e12858. Epub 2019 Apr 14.

Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

Evidence shows the possible link between insomnia and perinatal depressive symptoms. In order to find a convergent quantitative answer, we collected data via the search of Medline, EMBASE and reference tracking, which included nine studies (a total sample of 1,922 women). An aggregate effect size estimate (correlation coefficient) was generated using the comprehensive meta-analysis software. Read More

J Invasive Cardiol 2019 Apr 15. Epub 2019 Apr 15.

Minneapolis Heart Institute Foundation, 920 East 28th St, Suite 620, Minneapolis, MN 55407 USA.

Background: The burden and impact of sleep deprivation in cardiology has received limited study.

Methods: A multidisciplinary, online survey on sleep health patterns and sleep deprivation involving 44 closed-ended questions was distributed via email list to cardiovascular workers.

Results: The survey was circulated among 6683 individuals, of whom 481 (7. Read More

Cephalalgia 2019 Apr 13:333102419835466. Epub 2019 Apr 13.

1 Genetic Epidemiology Branch, National Institute of Mental Health, Bethesda, MD, USA.

Background: There is limited research on the association of sleep problems with International Classification of Headache Disorders (ICHD-II)-defined headache subtypes in youth, particularly from community-based samples. This cross-sectional study examines the associations of sleep patterns, symptoms and disorders with specific headache subtypes among adolescents from the general population of the United States.

Methods: The sample includes 10,123 adolescents in the National Comorbidity Survey - Adolescent Supplement, a face-to-face survey of adolescents aged 13-18 years in the continental USA. Read More

Clin Neurophysiol 2019 Mar 28;130(6):925-940. Epub 2019 Mar 28.

Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.

The pedunculopontine nucleus (PPN) is located in the mesopontine tegmentum and is best delimited by a group of large cholinergic neurons adjacent to the decussation of the superior cerebellar peduncle. This part of the brain, populated by many other neuronal groups, is a crossroads for many important functions. Good evidence relates the PPN to control of reflex reactions, sleep-wake cycles, posture and gait. Read More

J Affect Disord 2019 Mar 18;252:92-98. Epub 2019 Mar 18.

Unit of Psychiatry, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, China. Electronic address:

Background: Major depressive disorder (MDD) is a common psychiatric disorder which is associated with significant disability and psychosocial factors. There are only few epidemiological studies of MDD in economically underdeveloped regions of China. This study examined the 1-month and lifetime prevalence of MDD and their sociodemographic correlates in Hebei province, China. Read More

J Affect Disord 2019 Apr 8;252:74-83. Epub 2019 Apr 8.

Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China. Electronic address:

Background: A variety of functional metrics derived from resting-state functional magnetic resonance imaging (rs-fMRI) have been employed to explore spontaneous brain activity changes in major depressive disorder (MDD) and have enjoyed significant success in unraveling the neurobiological mechanisms underlying this disorder. However, it is unclear whether spatial and temporal coupling relationships among these rs-fMRI metrics are altered in MDD.

Methods: 50 patients with MDD and 36 well-matched healthy controls underwent rs-fMRI scans. Read More

J Affect Disord 2019 Apr 8;252:68-73. Epub 2019 Apr 8.

Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Background: The inflammation and oxidative stress are thought to play an important role in the etiopathogenesis of some psychological disorders. We aimed to assess the potential relationships between serum fat soluble vitamins (Vitamins A and E), antibody titers to Hsp27 (anti-Hsp27) and hematological markers of inflammation, with mood disorders in a population of adolescent girls.

Methods: A total of 563 adolescent girls (Age 12-18 years) were included in the study. Read More

Clin Gastroenterol Hepatol 2019 Apr 10. Epub 2019 Apr 10.

Institute of Biochemistry, Food Science and Nutrition, the Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University, Rehovot, Israel. Electronic address:

Background & Aims: Sleep disruption modifies the immune system and can trigger flares of inflammatory bowel diseases (IBD). Changes in expression of clock genes have been reported in patients with IBD. We investigated whether a change in the circadian clock is an early event in development of IBD. Read More

Phytomedicine 2019 Apr 4:152920. Epub 2019 Apr 4.

Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, Ankara 06100, Turkey. Electronic address:

Background: Identification of the low abundance of phytochemicals in plant extracts is very difficult. Pharmacological activity observed in such plants is not due to a single compound. In most cases, plant extracts show activity based on synergistic or antagonistic effects. Read More

Sleep Med Rev 2019 Mar 13;45:88-94. Epub 2019 Mar 13.

Special Needs in Oral Health, Sleep Breathing Disorders, Oral Health Sciences, Ghent University Hospital, Gent, Belgium.

Primary snoring, also known as simple or non-apnoeic snoring, is regarded as the first stage of sleep disordered breathing without severe medical consequences for the snorer and co-sleeper. Although it is a highly prevalent phenomenon in the general population, our knowledge is limited because of the lack of a consensus on terminology. This systematic review of the aspects used in the definitions of simple/primary snoring was conducted to obtain an inventory of current practices and compare these definitions with the conceptual definition of the American Academy of Sleep Medicine. Read More

J Oral Facial Pain Headache 2019 Apr 12. Epub 2019 Apr 12.

Aims: To evaluate the effectiveness of counseling on pain intensity and oral health-related quality of life (OHRQoL) in temporomandibular disorders (TMD) patients.

Methods: Fifty female patients diagnosed with TMD were divided into two groups: a group of waiting list patients (control group) and a group of patients who received counseling therapy (experimental group) involving education about etiologic factors, avoidance of parafunctional habits, and sleep, as well as dietary advice. All patients were evaluated at baseline and 7, 15, 30, and 60 days later. Read More

Can J Ophthalmol 2019 Apr 7;54(2):180-189. Epub 2018 Jun 7.

Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, Ont; Department of Ophthalmology, Schulich School of Medicine and Dentistry, Western University, London, Ont.. Electronic address:

Objective: To summarize and quantitatively evaluate sleep outcomes of dry eye disease (DED) patients.

Design: A systematic review and meta-analysis.

Participants: DED patients were individuals with dry eye symptoms or primary Sjogren's syndrome (pSS). Read More

Sleep Med 2019 Feb 19;57:122-127. Epub 2019 Feb 19.

Division of Neurology, Department of Clinical Medicine, Universidade Federal do Ceará, Brazil; Neurology Service, Hospital Geral de Fortaleza, Fortaleza, Ceará, Brazil; Center of Health Sciences, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil. Electronic address:

Purpose: The aim of this study was to clinically characterize sleep disorders in a cohort of Niemann-Pick type C (NPC) patients, correlating these findings with disease features and polysomnographic (PSG) results.

Methods: We evaluated eight consecutive patients with molecular confirmation of NPC followed at the Hospital Geral de Fortaleza. Patients underwent a comprehensive neurological and sleep evaluation. Read More

Elife 2019 Apr 11;8. Epub 2019 Apr 11.

Department of Biomedical Science, Washington State University, Spokane, United States.

Autism Spectrum Disorder (ASD) is the most prevalent neurodevelopmental disorder in the United States and often co-presents with sleep problems. Sleep problems in ASD predict the severity of ASD core diagnostic symptoms and have a considerable impact on the quality of life of caregivers. Little is known, however, about the underlying molecular mechanisms of sleep problems in ASD. Read More

CNS Spectr 2019 Apr 11:1-6. Epub 2019 Apr 11.

Department of Clinical and Experimental Medicine, Section of Psychiatry,University of Pisa,Pisa,Italy.

Objective: To investigate if sleep disturbances may affect treatment outcomes of patients with panic disorder (PD).

Methods: Eighty-five PD outpatients with no Axis I comorbidity for mood disorders completed a baseline assessment (T1) and were evaluated after 3 (T2), 6 (T3) and 12 months (T4), with the Panic Disorder Severity Scale (PDSS) total score as outcome measure during a 12-month naturalistic follow-up. Patients were assessed with the Mood Spectrum Self-Report (MOODS-SR, Lifetime Version), and the PDSS. Read More

Am J Mens Health 2019 Mar-Apr;13(2):1557988319842985

6 Department of Medical Research, Tri-Service General hospital, National Defense Medical Center, Taipei, Republic of China.

This study aimed to investigate the association between males with psychosexual disorders (PSDs) and the risk of developing psychiatric disorders. A total of 34,972 enrolled patients, with 8,743 subjects who had suffered from PSD and 26,229 controls (1:3) matched for age and index year, from Taiwan's Longitudinal Health Insurance Database (LHID) from 2000 to 2015, selected from the National Health Insurance Research Database (NHIRD). After adjusting all the confounding factors, the multivariate Cox regression model was used to compare the risk of developing psychiatric disorders, between the PSD and non-PSD groups, during the 15 years of follow-up. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Apr;33(4):313-318

Department of Sleep and Disorders, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510655, China.

This study was designed to show the preliminary efficacy and safety of the improved tongue base suspension surgery in severe obstructive sleep apnea(OSA) patients classified as Friedman Ⅱand Friedman Ⅲ. The severe OSA patients diagnosed by PSG as Friedman Ⅱ type and Ⅲ type underwent surgery treatment. The tongue base of the patient was implanted with titanium plate and fixed on the chin of mandible. Read More

Neuropsychobiology 2019 Apr 10:1-9. Epub 2019 Apr 10.

Center for Affective, Stress and Sleep Disorders (ZASS), Psychiatric Clinics (UPK), University of Basel, Basel, Switzerland,

Background: Individuals with lichen planopilaris (LPP) typically present with hair loss and an irritated scalp, with signs and symptoms such as itching, erythema, scaling, and burning. Both hair loss and reddened skin may be visible also for other people. Therefore, it is conceivable that individuals with LPP might report a lower mental health status. Read More

Arq Neuropsiquiatr 2019 Mar;77(3):179-183

Necmettin Erbakan University, Meram Faculty of Medicine, Department of Neurology, Konya, Turkey.

Objective: To determine the prevalence of bruxism and related factors in patients with multiple sclerosis (MS).

Methods: Diagnosed with relapsing-remitting MS under the 2010-revised McDonald diagnostic criteria, 182 patients without MS exacerbations during the previous three months were included in the patient group, and 145 healthy individuals made up the control group in the study. Demographic data of the participants in both groups were determined. Read More

Obstet Gynecol 2019 Apr 5. Epub 2019 Apr 5.

Stanford University, Stanford, California; Monash University, Melbourne, Australia; and Santa Clara Valley Medical Center, Fruitdale, California.

Objective: To evaluate the effectiveness of cognitive behavioral therapy for insomnia during pregnancy.

Methods: Randomized, unmasked, 3-site controlled trial. Participants were randomly allocated to cognitive behavioral therapy for insomnia (a first-line, empirically supported psychosocial intervention that addresses sleep-related behaviors and cognitions) or a control intervention consisting of imagery exercises that paired patient-identified distressing nighttime experiences with patient-identified neutral images. Read More