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Dement Geriatr Cogn Disord 2018 Dec 11;46(5-6):371-384. Epub 2018 Dec 11.

Department of Biomedical and NeuroMotor Sciences, Functional MR Unit, University of Bologna, Bologna,

Background: Bright light treatment is a therapeutic intervention mainly used to treat sleep and circadian disturbances in Alzheimer's disease (AD) patients. Recently, a handful of studies also focused on the effect on cognition and behavior. Conflicting findings are reported in the literature, and no definite conclusions have been drawn about its specific therapeutic effect. Read More

ORL J Otorhinolaryngol Relat Spec 2018 Dec 11;81(1):16-23. Epub 2018 Dec 11.

Department of Otolaryngology and Head and Neck Surgery, Wakayama University Hospital, Wakayama, Japan.

Background/aims: The aim of this study was to observe the relationship between the gene expression profiles of tumor necrosis factor (TNF)-α and endothelin (EDN)-1 and obstructive sleep apnea (OSA).

Methods: A prospective, cross-sectional study performed at a tertiary-care academic center; 108 patients with snoring and day-time sleeplessness were included in this study carried out in the Otolaryngology Department. All patients were evaluated with 1-night polysomnography (PSG). Read More

Med Princ Pract 2018 Dec 11. Epub 2018 Dec 11.

Objective: To investigate the influence of sleep apnea on ECG and blood pressure monitoring parameters in patients with acute heart failure (AHF).

Methods: 51 hospitalized patients with AHF (13 women, 38 men, mean age 60.8 years) underwent 24-hour combined monitoring of ECG and blood pressure and sleep apnea testing before discharge. Read More

Sleep Med Rev 2018 Nov 16;43:96-105. Epub 2018 Nov 16.

Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine University of Freiburg, Germany.

Previous research has identified insomnia as a predictor for the onset of depression. The aim of this meta-analysis is to investigate whether insomnia also predicts the onset of other mental disorders. Longitudinal studies were eligible for inclusion if they investigated insomnia at baseline (including nighttime- and daytime-symptoms) as a predictor of the later onset of psychopathology within a follow-up time-frame of at least 12 mo. Read More

Sleep Med Rev 2018 Nov 10;43:92-95. Epub 2018 Nov 10.

Sleep Medicine Services, Lankenau Medical Center, Wynnewood, PA, USA; Lankenau Institute for Medical Research, Wynnewood, PA, USA; Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA; Charles Widger School of Law, Villanova University, Villanova, PA, USA. Electronic address:

The DSM-5 and ICSD-3 have removed alcohol from the list of potential triggers for sleepwalking due to the lack of empirical evidence. Recent imaging and EEG based studies of sleepwalking and confusional arousals have provided a more data-based method of examining if alcohol is compatible with what is known about the neurophysiology and neurochemistry of sleepwalking. These studies have demonstrated a deactivation of the frontal areas of the brain, while the cingulate or motor cortex remains active and characterized activation in the form of beta EEG. Read More

J Allergy Clin Immunol Pract 2018 Dec 8. Epub 2018 Dec 8.

Oregon Health & Science University, Portland, OR.

Background: The impact of atopic dermatitis (AD) on health related quality of life and health utility in the United States adult population is not well-established.

Objectives: To determine the health utilities and quality of life adjusted years (QALYs) lost in adults with vs. without AD among the US population. Read More

Neurosci Biobehav Rev 2018 Dec 8. Epub 2018 Dec 8.

Department of Pediatrics, Dalhousie University and the IWK Health Centre, Canada.

Regression in children with epilepsy may involve loss of cognitive abilities, failure to progress or a slowing of developmental trajectory. A few seizures do not lead to regression. Large numbers of seizures may be associated with regression but the cause is an important cofounder. Read More

Am J Primatol 2018 Dec;80(12):e22932

Department of Anthropology, University of California, Davis, California.

Predation is widely recognized as an important selective pressure on prey animals such as baboons (Papio spp.), which face high leopard (Panthera pardus) predation risk, particularly at night. Baboons regularly sleep on cliff faces and in trees at night, ostensibly to avoid such predators. Read More

J Sleep Res 2018 Dec 9:e12803. Epub 2018 Dec 9.

Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Japan.

This study examined whether sleep duration and excessive daytime sleepiness (EDS) are related to cognitive decline among community-dwelling older adults with intact cognition at baseline, using 4-year longitudinal data. A total of 3,151 community-dwelling older individuals aged ≥65 years were studied. They were assessed for cognitive function, including memory, attention, executive function and processing speed. Read More

Int J Older People Nurs 2018 Dec 7:e12215. Epub 2018 Dec 7.

Public Health Nursing Department, Florence Nightingale Nursing Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Background: Sleep problems are much more prevalent in nursing home residents than in their community-dwelling counterparts. Cognitive behavioural therapy is likely to improve sleep quality in older adults. However, these interventions have a narrow scope to generalise to nursing home practice, and there are minimal data on the effectiveness of the integration of cognitive behavioural therapy and motivational interviewing in nursing home settings. Read More

Int Forum Allergy Rhinol 2018 Dec 10. Epub 2018 Dec 10.

Division of Rhinology, Department of Otolaryngology-Head and Neck Surgery, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.

Background: Previous studies on the impact of wait times for endoscopic sinus surgery (ESS) in medically recalcitrant chronic rhinosinusitis (rCRS) have not examined its influence on the 5 distinct symptoms domains of the 22-item Sino-Nasal Outcome Test (SNOT-22), and have not applied evidence-based surgical indications. Our primary study objective was to investigate the impact of ESS wait times on postoperative SNOT-22 global and symptom domain scores in patients with rCRS deemed "appropriate" surgical candidates.

Methods: This was a retrospective analysis of adult patients with rCRS undergoing ESS, categorized as "appropriate" surgical candidates. Read More

Pediatr Int 2018 Nov;60(11):997

Department of Pediatrics, Juntendo University Nerima Hospital, Tokyo, Japan.

Obes Surg 2018 Dec 7. Epub 2018 Dec 7.

Programa de Pós-Graduação em Ciências da Saúde: Ginecologia e Obstetrícia, UFRGS, Porto Alegre, Brazil.

Background: Obesity and its complications are prevalent in women and increase with age. Polyneuropathy (PNP) is a complication of obesity and bariatric surgery (BS). In subjects with severe (grades II and III) obesity and without DM who are candidates for BS, the prevalence of PNP and associated conditions are not well characterized. Read More

Obes Surg 2018 Dec 7. Epub 2018 Dec 7.

General Surgery, Mayo Clinic, Jacksonville, FL, USA.

Background: Indications and outcomes of bariatric surgery in the elderly remain controversial. We aimed to evaluate and compare safety and early outcomes of bariatric procedures in this age group.

Study Design: We performed a retrospective case-control study of Mayo Clinic bariatric surgery patients from January 1, 2016, to January 31, 2018. Read More

J Med Syst 2018 Dec 10;43(1):15. Epub 2018 Dec 10.

Stanford Byers Center for Biodesign, Stanford University School of Medicine, Stanford, CA, USA.

We append two additional funders to our acknowledgments. Read More

Exp Brain Res 2018 Dec 10. Epub 2018 Dec 10.

Department of Neuro-Regeneration, Fukushima Medical University, 1 Hikarigaoka, Fukushima, Fukushima, Japan.

Caffeine, an adenosine receptor antagonist, is known to affect sleep-awake cycles, the stress response, and learning and memory. It has been suggested that caffeine influences synaptic plasticity, but the effects of caffeine on synaptic plasticity in the human brain remain unexplored. The present study aimed to investigate the effects of caffeine on long-term potentiation (LTP)-like effects in the primary motor cortex of healthy humans. Read More

Int J Public Health 2018 Dec 10. Epub 2018 Dec 10.

Department of Public Health, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.

Objectives: We examined changes in sleep-onset difficulties over time and associations with physical activity and screen time behavior among adolescents.

Methods: We used data from last four survey waves of the Health Behavior in School-Aged Children (HBSC) study (2002-2006-2010-2014). Multilevel logistic regression analyses were conducted to explore associations between regular sleeping difficulties, excessive screen time exposure and being insufficiently physically active (i. Read More

Sleep Breath 2018 Dec 7. Epub 2018 Dec 7.

Department of Respiratory Disease, The First Affiliated Hospital of Fujian Medical University, No.20 Chazhong Road, Fuzhou, 350005, Taijiang District, China.

Purpose: Long non-coding RNAs (lncRNAs) are a recently identified class of regulatory molecules involved in the regulation of numerous biological processes, but their functions in a rat model of chronic intermittent hypoxia (CIH) remain largely unknown. Therefore, for further investigation, we aimed to explore lncRNA expression profiles and reveal their potential functional roles in rat models of CIH.

Methods: We used a well-established CIH rat model and conducted lncRNA microarray experiments on the heart samples of rats with CIH and under normoxia control. Read More

Sleep 2018 Dec 10. Epub 2018 Dec 10.

Nicotine Tob Res 2018 Dec 11. Epub 2018 Dec 11.

University at Buffalo, The State University of New York.

Introduction: Assessment of withdrawal symptoms, treatment mechanisms, and side effects is central to understanding and improving smoking cessation interventions. Though each domain is typically assessed separately with widely-used questionnaires to separately assess each domain (e.g. Read More

J Clin Endocrinol Metab 2018 Dec 6. Epub 2018 Dec 6.

Department of Internal Medicine I, University of Lübeck, Lübeck, Germany.

Context: Chronodisruption as caused by e.g. perturbations of 24h-rhythms of physiology and behavior clearly may promote the development of metabolic diseases. Read More

Cereb Cortex 2018 Dec 7. Epub 2018 Dec 7.

Laboratory of Neuro Imaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, USA.

Brain structural morphology differs with age. This study examined age-differences in surface-based morphometric measures of cortical thickness, volume, and surface area in a well-defined sample of 8137 generally healthy UK Biobank participants aged 45-79 years. We illustrate that the complexity of age-related brain morphological differences may be related to the laminar organization and regional evolutionary history of the cortex, and age of about 60 is a break point for increasing negative associations between age and brain morphology in Alzheimer's disease (AD)-prone areas. Read More

JAMA 2018 Dec;320(22):2354-2364

Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.

Importance: Atrial fibrillation (AF) is the most common arrhythmia affecting 1% of the population. Young individuals with AF have a strong genetic association with the disease, but the mechanisms remain incompletely understood.

Objective: To perform large-scale whole-genome sequencing to identify genetic variants related to AF. Read More

Sleep 2018 Dec;41(12)

Department of Psychiatry and Behavioral Medicine, Howard University College of Medicine, Washington, DC.

Sleep 2018 Dec;41(12)

Department of Developmental and Behavioral Pediatrics, Pediatric Translational Medicine Institution, Shanghai Childrenges Medical Center, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Study Objectives: To examine trajectories of poor sleep quality from late pregnancy to 36 months postpartum, baseline indicators, and association with prospective maternal mood disturbances.

Methods: A cohort of 262 nonclinical women was followed at late pregnancy, 42 days, 3, 6, 9, 12, 18, 24, and 36 months postpartum. Sleep quality was measured with the Pittsburgh Sleep Quality Index at all time points, and mood disturbances were assessed at late pregnancy and 36 months postpartum. Read More

J Am Med Inform Assoc 2018 Dec 7. Epub 2018 Dec 7.

School of Nursing, Columbia University, New York City, New York USA.

Objective: To systematically synthesize the literature on information visualizations of symptoms included as National Institute of Nursing Research common data elements and designed for use by patients and/or healthcare providers.

Methods: We searched CINAHL, Engineering Village, PsycINFO, PubMed, ACM Digital Library, and IEEE Explore Digital Library to identify peer-reviewed studies published between 2007 and 2017. We evaluated the studies using the Mixed Methods Appraisal Tool (MMAT) and a visualization quality score, and organized evaluation findings according to the Health Information Technology Usability Evaluation Model. Read More

Sleep 2018 Dec 11. Epub 2018 Dec 11.

AfaSci Research Laboratories, Redwood City, California, USA.

Study Objectives: A major challenge in treating insomnia is to find effective medicines with fewer side effects. Activation of G-protein-gated inward rectifying K+ channels (GIRKs) by GABAB agonists baclofen or γ-hydroxybutyric acid (GHB) promotes non-rapid eye movement (NREM) sleep and consolidates sleep. However, baclofen has poor brain penetration, GHB possesses abuse liability, and in rodents both drugs cause spike-wave discharges (SWDs), an absence seizure activity. Read More

Pain Med 2018 Dec 7. Epub 2018 Dec 7.

Neurology Department, University Clinical Hospital Lozano Blesa, Instituto Aragonés de Ciencias de la Salud, Grupo de Estudio de Trastornos del Movimiento y Cefaleas (GIIS070), Zaragoza, Spain; Neurology Department, University Clinical Hospital Lozano Blesa, Zaragoza, Spain.

Background. : Cluster headache is one of the most disabling of all headache conditions. Although some studies have investigated the psychological profile of patients with cluster headache, research on its impact on cognitive function in patients with episodic cluster headache outside the cluster bout is scant. Read More

Arab J Urol 2018 Dec 25;16(4):404-410. Epub 2018 Jul 25.

Department of Urology, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.

Objective: To evaluate the effect of oral desmopressin in patients with nocturia associated with benign prostatic hyperplasia (BPH).

Patients And Methods: With a rise of the use of oral desmopressin in the treatment of nocturia in patients with BPH, a systematic review was performed according to the Cochrane systematic reviews guidelines and in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist.

Results: The literature search yielded 18 studies. Read More

Biopsychosoc Med 2018 26;12:17. Epub 2018 Nov 26.

2Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, 35 Shinamomachi, Shinjuku, Tokyo, 1608582 Japan.

Background: There have been many reports on the treatment effect of cochlear implantation and hearing aids in the treatment of tinnitus in patients with severe hearing loss. However, as far as we are aware, there are no reports of investigation of treatment approaches for the tinnitus of deaf patients whose communication is solely carried out in sign language due to a long duration of deafness.

Case Presentation: We experienced a case of severe tinnitus with bilateral deafness for more than 50 years. Read More

Front Hum Neurosci 2018 26;12:452. Epub 2018 Nov 26.

Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom.

Electroencephalography (EEG) recordings represent a vital component of the assessment of sleep physiology, but the methodology presently used is costly, intrusive to participants, and laborious in application. There is a recognized need to develop more easily applicable yet reliable EEG systems that allow unobtrusive long-term recording of sleep-wake EEG ideally away from the laboratory setting. cEEGrid is a recently developed flex-printed around-the-ear electrode array, which holds great potential for sleep-wake monitoring research. Read More

Front Cell Neurosci 2018 26;12:454. Epub 2018 Nov 26.

Department of Radiology, Xinqiao Hosptial, Third Military Medical University, Chongqing, China.

: Early postmenopausal women frequently suffer from cognitive impairments and emotional disorders, such as lack of attention, poor memory, deficits in executive function and depression. However, the underlying mechanisms of these impairments remain unclear. : Forty-three early postmenopausal women and forty-four age-matched premenopausal controls underwent serum sex hormone analysis, neuropsychological testing and resting-state functional magnetic resonance imaging (rs-fMRI). Read More

Neurol Genet 2018 Dec 7;4(6):e281. Epub 2018 Nov 7.

Objective: To provide new insights into the related clinical and imaging phenotypes and refine the phenotype-genotype correlation in syndrome.

Methods: We analyzed the clinical and imaging phenotypes of a cohort of 45 patients with a pathogenic or likely pathogenic variant and performed phenotype-genotype correlations.

Results: A total of 37 different heterozygous mutations were identified, of which 18 are novel. Read More

Pain Res Manag 2018 4;2018:5801510. Epub 2018 Nov 4.

University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, Netherlands.

Objective: The aim of the current study was to compare physical activity and sleep duration between patients with chronic fatigue syndrome (CFS), patients with fibromyalgia syndrome (FMS), and controls and to examine the association between physical activity level and sleep duration with symptom severity within these patient groups.

Methods: This study used data of LifeLines, a general population cohort in which 1.0% (=943, 63. Read More

Can Respir J 2018 6;2018:2157974. Epub 2018 Nov 6.

Department of Orthodontics, Case Western Reserve University, Cleveland, USA.

Obstructive sleep apnea (OSA) is a common but still underrecognized disorder. A mandibular repositioning appliance (MRA) is used to treat OSA by advancing the mandible and thereby reducing the collapsibility of the upper airway. It has been found that an MRA increases the volume of the upper airway, especially the velopharyngeal area, in OSA patients. Read More

Front Psychol 2018 23;9:2316. Epub 2018 Nov 23.

Faculty of Psychology, University of Warsaw, Warsaw, Poland.

Tendency toward healthy and health-risk behavior is associated with external factors, and healthy lifestyle affects its quality. Activation of Behavioral Inhibition System (BIS) and Behavioral Activation System (BAS) and its association with sleeping habits provides insight into the correlates of voluntary sleep deprivation. Aim of the study was to evaluate the relationship between BIS/BAS activity and reasons for voluntary sleep deprivation among young adults and to assess benefits and costs of decreasing sleep duration. Read More

Front Neurosci 2018 23;12:860. Epub 2018 Nov 23.

Department of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, China.

Primary insomnia (PI) is the second most common mental disorder. However, the topologic alterations in structural brain connectome in patients with PI remain largely unknown. A total of 44 PI patients and 46 age-, gender-, and education level matched healthy control (HC) participants were recruited in this study. Read More

Mediators Inflamm 2018 8;2018:6808934. Epub 2018 Nov 8.

Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

Retinoic acid-inducible gene I (RIG-I) is an important regulator of virus-induced antiviral interferons (IFNs) and proinflammatory cytokines. It requires interaction with an adaptor molecule, mitochondrial antiviral-signaling protein (MAVS), to activate downstream signaling pathways. To elucidate the mechanism(s) by which RIG-I-dependent recognition of IAV infection triggers innate immune responses, we infected mutant mice lacking RIG-I or MAVS with influenza A virus (IAV) and measured their innate immune responses. Read More

Saudi Pharm J 2018 Dec 7;26(8):1127-1136. Epub 2018 Jul 7.

Woolcock Institute of Medical Research, University of Sydney, NSW, Australia.

Objectives: To investigate the effect of inhaler technique education delivered by a clinical pharmacist to patients hospitalised for asthma, on inhaler technique scores and asthma control at three months post-discharge.

Methods: This pre-post interventional study in Jordan enrolled patients who had been admitted for asthma and were using controller medication by Accuhaler [Diskus] (ACC), Turbuhaler (TH) or Pressurized metered dose inhalers (pMDI). Inhaler technique was assessed using published checklists (score 0-9). Read More

Pediatric Health Med Ther 2018 16;9:157-163. Epub 2018 Nov 16.

Department of Midwifery and Reproductive Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Infantile colic viewed as a non-dangerous prevalent issue could lead to stress in parents and long-term negative consequences in ex-colicky children. Researchers have not been successful in finding a certain treatment for colic symptoms. Studies suggest completely different approaches as its treatment. Read More

Appl Clin Genet 2018 15;11:135-144. Epub 2018 Nov 15.

Division of Pediatric Pulmonology and Sleep Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA,

Congenital central hypoventilation syndrome (CCHS) is a rare genetic disorder of the autonomic nervous system (ANS) and respiratory control. This disorder, formerly referred to as Ondine's curse, is due to a mutation in the gene that affects the development of the neural crest cells. CCHS has an autosomal dominant pattern of inheritance. Read More

PLoS One 2018 7;13(12):e0208502. Epub 2018 Dec 7.

Biomedical Engineering Group, Universidad de Valladolid, Valladolid, Spain.

Background: The gold standard for pediatric sleep apnea hypopnea syndrome (SAHS) is overnight polysomnography, which has several limitations. Thus, simplified diagnosis techniques become necessary.

Objective: The aim of this study is twofold: (i) to analyze the blood oxygen saturation (SpO2) signal from nocturnal oximetry by means of features from the wavelet transform in order to characterize pediatric SAHS; (ii) to evaluate the usefulness of the extracted features to assist in the detection of pediatric SAHS. Read More

PLoS One 2018 7;13(12):e0208540. Epub 2018 Dec 7.

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America.

The relationship between cardiovascular disease and abnormalities in sleep architecture is complex and bi-directional. Sleep disordered breathing (SDB) often confounds human studies examining sleep in the setting of heart failure, and the independent impact of isolated right or left heart failure on sleep is difficult to assess. We utilized an animal model of right heart failure using pulmonary artery banding (PAB) in mice to examine the causal effect of right heart failure on sleep architecture. Read More

PLoS One 2018 7;13(12):e0208761. Epub 2018 Dec 7.

Department of Social and Health Systems Research, National Institute for Health and Welfare, Helsinki, Finland.

Background: A growing body of research indicates that cross-cultural competence in nurses can improve migrant patients' health-related outcomes, but little is known about the potential benefits of cross-cultural competence on the nurses' own well-being.

Objective: To examine whether cross-cultural competence (empathy, skills, positive attitudes, and motivation) is associated with perceived time pressure at work, psychological distress, and sleep problems among registered nurses in Finland, and whether there are differences in these potential associations between native and foreign-born nurses.

Methods: The present cross-sectional study was based on a sample of 212 foreign-born nurses licensed to practice in Finland and a random sample of 744 native Finnish nurses. Read More

Nat Commun 2018 Dec 10;9(1):5257. Epub 2018 Dec 10.

Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, OX3 7LF, UK.

Physical activity and sleep duration are established risk factors for many diseases, but their aetiology is poorly understood, partly due to relying on self-reported evidence. Here we report a genome-wide association study (GWAS) of device-measured physical activity and sleep duration in 91,105 UK Biobank participants, finding 14 significant loci (7 novel). These loci account for 0. Read More

Nat Rev Endocrinol 2018 Dec 7. Epub 2018 Dec 7.

Department of Endocrinology and Metabolism, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.

Insulin resistance is a main determinant in the development of type 2 diabetes mellitus and a major cause of morbidity and mortality. The circadian timing system consists of a central brain clock in the hypothalamic suprachiasmatic nucleus and various peripheral tissue clocks. The circadian timing system is responsible for the coordination of many daily processes, including the daily rhythm in human glucose metabolism. Read More

Curr Opin Anaesthesiol 2018 Dec 6. Epub 2018 Dec 6.

Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Miller School of Medicine, University of Miami.

Purpose Of Review: Tattoos and medallions are examples of nonstandard do-not-resuscitate (DNR) orders that some people use to convey end-of-life wishes. These DNR orders are neither universally accepted nor understood for reasons discussed within this manuscript.

Recent Findings: Studies show both providers and patients confuse the meaning and implication of DNR orders. Read More

Med Sci Sports Exerc 2018 Dec 5. Epub 2018 Dec 5.

Department of Physical Education and Sport Sciences, University of Limerick, Limerick, Ireland.

Recent findings support positive effects of acute aerobic exercise on worry, state anxiety, and feelings of energy and fatigue among young adult women with subclinical, or analogue, Generalized Anxiety Disorder (GAD). However, exercise effects among young adult men with analogue GAD are unstudied.

Purpose: This study replicated initial findings of positive effects of acute vigorous-intensity aerobic exercise on worry, state anxiety, and feelings of energy and fatigue among young adult women with analogue GAD, examined responses among young adult men with analogue GAD, and explored sex-related differences and moderation by physical activity level, trait anxiety, depression, and poor sleep status. Read More

Surg Laparosc Endosc Percutan Tech 2018 Dec 10. Epub 2018 Dec 10.

Department of General Surgery, Kaizhou People Hospital, Chongqing, China.

Introduction: The efficacy of melatonin to improve sleep quality after laparoscopic cholecystectomy remains controversial. We conduct a systematic review and meta-analysis to explore the influence of melatonin intervention versus placebo on sleep quality after laparoscopic cholecystectomy.

Methods: We searched PubMed, EMbase, Web of Science, EBSCO, and Cochrane library databases through July 2018 for randomized controlled trials assessing the effect of melatonin intervention versus placebo on sleep quality after laparoscopic cholecystectomy. Read More

Curr Opin Crit Care 2018 Dec 10. Epub 2018 Dec 10.

Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine.

Purpose Of Review: To provide an overview of the current research in identifying homogeneous subgroups and phenotypes in ARDS.

Recent Findings: In recent years, investigations have used either physiology, clinical data, biomarkers or a combination of these to stratify patients with ARDS into distinct subgroups with divergent clinical outcomes. In some studies, there has also been evidence of differential treatment response within subgroups. Read More