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Gac Med Mex 2022 ;158(2):104-109

Neuroimmunoendocrinology Laboratory, Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez".

Introduction: Fibromyalgia (FM) is a non-degenerative syndrome characterized by generalized, chronic musculoskeletal pain, as well as mood, memory and sleep disorders.

Objective: To search for serum anti-neural antibodies (ANeuA) in patients with FM (FMP) in order to rule out autoimmune etiology.

Methods: The Fibromyalgia Impact Questionnaire (FIQ) and Beck's depression inventory (BDI) were applied. Read More

Invest Radiol 2022 Mar 29. Epub 2022 Mar 29.

Institute of Neuroradiology, University Hospital of LMU Munich.

Objectives: Recently, a novel clearing system for interstitial solutes of the brain was described as a perivascular pathway named the glymphatic system. Furthermore, lymphatic vessels were found in the meninges to drain interstitial fluids. It is hypothesized that interstitial solutes, such as amyloid β, are firstly processed through the brain by the glymphatic system and secondly drained out of the brain by lymphatic vessels (glymphatic-lymphatic fluid transport system [GLS]). Read More

Sleep 2022 Jun 28. Epub 2022 Jun 28.

Center on Biological Rhythms and Sleep (COBRAS), Washington University School of Medicine, St. Louis, Missouri, USA.

Comb Chem High Throughput Screen 2022 Jun 27. Epub 2022 Jun 27.

State Key Laboratory of NBC Protection for Civilians, Beijing 102205, China.

Background The incidence of sleep disorders is more than 27% in the worldwide, and the development of novel sleep drugs that target GABAA receptors is of great interest. Traditional drug screening methods restrict the discovery of lead compounds, the high-throughput screening system is a powerful means for the lead compounds discovery of sleep drug. Methods The GABAA1-CHO cell line stably expressing α1β2γ2L was constituted by co-transfection of α1, β2 and γ2L subunits into CHO-T-Rex cells. Read More

Sleep Epidemiol 2021 Dec 25;1. Epub 2021 Nov 25.

Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA.

Study Objectives: Clinical and population health recommendations are derived from studies that include self-report. Differences in question wording and response scales may significantly affect responses. We conducted a methodological review assessing variation in event definition(s), context (i. Read More

Nat Sci Sleep 2022 21;14:1175-1186. Epub 2022 Jun 21.

Department of Acupuncture & Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 610075, People's Republic of China.

Background: Gender differences in hippocampal and parahippocampal gyrus (HIP/PHG) volumes have been reported in sleep disorders. Therefore, this study investigated the moderating effect of gender on the relationship between chronic insomnia disorder (CID) and the HIP/PHG functional connectivity (FC) network.

Methods: For this study, 110 patients diagnosed with CID (43 men and 67 women) and 60 matched good sleep control (GSC) (22 men and 38 women) were recruited. Read More

J Occup Environ Med 2022 Jun;64(6):e374-e377

From the Department of Emergency Medicine, Chungbuk National University Hospital, Seowon-gu, Cheongju-si, Chungcheongbuk-do, South Korea (Shin, Dr Park, Dr Chai, Dr Kim, Dr Lee, and Dr Kim); Strategic Research, Laerdal Medical, Stavanger, Norway (Dr Kong); Department of Paramedic Science, Korea National University of Transportation, Jeungpyeong-gun, Chungcheongbuk-do, South Korea (Shin); Department of Emergency Medicine, College of Medicine, Chungbuk National University, Seowongu, Cheongjusi, Chungcheongbuk-do, South Korea (Dr Kim, Dr Lee, and Dr Kim).

Objectives: This study aimed to identify the association between the healthrelated characteristics and the subscales of occupational stress of live fire instructors and heart rate variability (HRV).

Methods: We conducted questionnaire survey on a general health checkup for 15 live fire instructors. Occupational stress and HRV parameters were measured to determine the association between health behavior, including smoking, drinking, exercise, and sleep-related disorders, and occupational stress of live fire instructors and HRV parameters using Spearman's rank correlation coefficient. Read More

J Affect Disord 2022 Jun 24. Epub 2022 Jun 24.

Amsterdam UMC location Vrije University Amsterdam, Department of Psychiatry, Amsterdam Public Health (Mental Health program) and Amsterdam Neuroscience (Mood, Anxiety, Psychosis, Stress & Sleep program) research institutes, Amsterdam, the Netherlands. Electronic address:

Background: Childhood trauma (CT) is a risk factor for depressive and anxiety disorders. However, whether CT is more strongly linked to specific clinical features of these disorders remains inconclusive. The current study comprehensively examined cross-sectional and longitudinal associations between CT and depressive/anxiety symptomatology in a large adult sample with current and remitted depressive and/or anxiety disorders. Read More

Res Dev Disabil 2022 Jun 24;128:104271. Epub 2022 Jun 24.

Sleep Education and Research Laboratory, UCL Institute of Education, London, UK. Electronic address:

Background: There is a growing body of research studying the impact sleep has on attention among typically developing (TD) children, but research is lacking among autistic children.

Aims: The present study aimed to explore, for the first time, differences in (1) attention, (2) sleep parameters among primary school-aged Singaporean autistic children (N = 26) and Singaporean TD children (N = 20), and with UK autistic (N = 11) and UK TD children (N = 16), and (3) the impact of sleep on attention.

Methods And Procedures: Actigraphy was used to objectively assess sleep, and a Continuous Performance Task was used to measure attentional domains. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2022 ;122(5. Vyp. 2):58-64

Krasnoyarsk Scientific Center of the Siberian Branch - Research Institute for Medical Problems in the North, Krasnoyarsk, Russia.

Objective: To establish the relationship between disturbances of the regime and quality of night sleep and daytime sleepiness in adolescents from Central Siberia with internet addiction with different types of content consumed.

Material And Methods: A single cross-sectional observational study of a school sample in three large cities in Siberia was performed. The study included 4615 schoolchildren aged 12-18 years (46. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2022 ;122(5. Vyp. 2):48-51

Herzen State Pedagogical University of Russia, St Petersburg, Russia.

The article describes pathogenetic models for insomnia: «3P» model of insomnia, hyperarousal model, and sleep reactivity to stress model. Anxiety and stress are addressed as predisposing, precipitating and perpetuating factors of insomnia. The problem of high comorbidity of insomnia and mental disorders is highlighted. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2022 ;122(5. Vyp. 2):35-41

Moscow Institute of Physics and Technology, Moscow, Russia.

Objective: To study the effectiveness and safety of the sleep normalization medical device SONYA in the treatment of insomnia.

Material And Methods: The effectiveness and safety of the SONYA device was studied in 32 subjects randomized into two groups - those who received stimulation using this device and those who received false stimulation (placebo). The indicators of subjective sleep characteristics, polysomnography, and emotional state were evaluated. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2022 ;122(5. Vyp. 2):29-34

Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

The reorganization of treatment facilities during the COVID-19 pandemic has altered the working conditions of large numbers of the health workers (HW) worldwide. The implementation of professional activities in such realities has led to an increased risk of developing a number of psychological disorders, including insomnia. The percentage of insomnia in HW has increased significantly. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2022 ;122(5. Vyp. 2):23-28

International Society for the Study of Stress «Stress under control», Moscow, Russia.

The pandemic of coronavirus infection, which has begun in 2019, has not ended to this day. COVID-19 adversely affects human health not only in the acute period of the disease, but also in the long-run: in a large percentage of cases, recovery takes very long, patients require and often have problems returning to their baseline. During the first wave of the pandemic in 2020, researchers noted that about 10-20% of patients didn't fully recover three weeks after the onset of the disease. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2022 ;122(5. Vyp. 2):11-17

Institute of Higher Nervous Activity and Neurophysiology, Moscow, Russia.

Sleep restriction and sleep disturbances are very common in modern industrialized societies, increasing the risk for the development of chronic sleep deficiency in the long term. Sleep disturbances are known to affect cognitive functions, primarily, working memory - the ability to store, update, and manipulate information over brief intervals for use in complex cognitive problems solving. However, the specific mechanisms underlying the decline in working memory due to disturbed sleep are still unclear. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2022 ;122(5. Vyp. 2)

In recent years, the problem of sleep disturbance has become particularly acute. The epidemic of coronavirus infection and lockdowns, the flow of contradictory information, as well as the decline in well-being have led to an almost threefold increase in the frequency of sleep disorders against the background of a surge in anxiety and depressive disorders. At the same time, the impact on sleep of foreign policy events and domestic tensions is still awaiting evaluation. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2022 ;122(6):55-62

Pirogov Russian National Research Medical University, Moscow, Russia.

Objective: Determination of the dose-dependent effect of the Teraligen for various nosological forms of disorders in psychiatric practice and general medicine.

Material And Methods: Analysis of 98 publications included in the database of the RISC (2012-2021) with the identification of disorders (according to ICD-10) in which Teraligen is prescribed or can be used (in adults and children from the age of 7).

Results: Despite a rather long and successful history use, research work on the study drug Teraligen continues. Read More

Soc Work Public Health 2022 Jun 26:1-10. Epub 2022 Jun 26.

Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Social workers are often front line behavioral health providers for underserved populations, many of whom experience sleep disturbances. Inadequate sleep presents a public health challenge and is associated with many adverse physical health and mental health consequences. Social workers are uniquely positioned to promote sleep health among individuals experiencing health inequities. Read More

Front Immunol 2022 1;13:892534. Epub 2022 Jun 1.

Department of Clinical Pharmacology and Pharmacotherapy, KU Leuven, Leuven, Belgium.

Serum albumin (SA), the most abundant soluble protein in the body, maintains plasma oncotic pressure and regulates the distribution of vascular fluid and has a range of other important functions. The goals of this review are to expand clinical knowledge regarding the functions of SA, elucidate effects of dysregulated SA concentration, and discuss the clinical relevance of hypoalbuminemia resulting from various diseases. We discuss potential repercussions of SA dysregulation on cholesterol levels, liver function, and other processes that rely on its homeostasis, as decreased SA concentration has been shown to be associated with increased risk for cardiovascular disease, hyperlipidemia, and mortality. Read More

Front Public Health 2022 9;10:848909. Epub 2022 Jun 9.

Faculty of Health Sciences, College of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia.

Background: Patients with depressed mental disorders may experience a lack of interest or pleasure, a poor mood, feelings of guilt or unworthiness, sleep and appetite disturbances, and easy fatigability. Based on the degree of the condition, depression is classed as mild, moderate, or severe. Maternal depression is the most common psychiatric condition during pregnancy, and its harmful effects have serious ramifications for both the mother and the fetus. Read More

Front Public Health 2022 9;10:888331. Epub 2022 Jun 9.

School of Kinesiology and Health Science, York University, Toronto, ON, Canada.

Background: Sleep deprivation and poor sleep quality contribute to increases in oxidative stress, antioxidant imbalance, and a pro-inflammatory state which may predispose to a higher risk of diabetes. Our objective was to estimate the contributions of C-reactive protein (CRP), gamma glutamyl transferase (GGT), and micronutrient antioxidants (bilirubin, carotenoids, uric acid, vitamins A, C-E?) to the relationships between sleep-fasting insulin concentration and -glycosylated hemoglobin (HbA1c).

Methods: Data from the 2005/06 US National Health and Nutritional Examination Survey were used ( = 1,946; 20 y+). Read More

Front Neurosci 2022 10;16:838486. Epub 2022 Jun 10.

Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States.

The prevalence of sleep disruptions is higher among people with alcohol use disorder (AUD), particularly during alcohol withdrawal, compared to non-AUD individuals. Although women generally have a higher risk of developing sleep disorders, few studies have investigated sex differences in sleep disruptions following chronic alcohol exposure. The present study examined sleep macroarchitecture (time spent asleep or awake and sleep onset latency) and microarchitecture (bout rate and duration and sleep spindle characterization) prior to alcohol vapor exposure (baseline), during acute withdrawal, and through protracted abstinence in female and male rats. Read More

Front Psychiatry 2022 10;13:898990. Epub 2022 Jun 10.

Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, Obu, Japan.

Psychological resilience refers to the ability to cope with adversities, and deficits in resilience might lead to mental illness. The COVID-19 pandemic has had impact on psychological resilience for older adults, but there are as yet no data on its impacts on the mental health of older adults who were living with mild cognitive impairment (MCI). Therefore, the aim of this study was to investigate the impact of the COVID-19 pandemic on psychological resilience in older adults with MCI and to explore associated physical and psychosocial factors. Read More

Front Psychiatry 2022 9;13:898600. Epub 2022 Jun 9.

Department of Sleep-Wake Disorders, National Institute of Mental Health, National Center of Neurology & Psychiatry, Tokyo, Japan.

Background: Delay in sleep-wake rhythms was observed in the general population during the coronavirus disease 2019 (COVID-19) pandemic. Patients with delayed sleep-wake phase disorder (DSWPD) may have also experienced exacerbation of symptoms, but no studies have investigated this topic. In this study, we aimed to retrospectively examine the changes in symptoms of outpatients with DSWPD both before and during the pandemic and to identify the factors associated with the exacerbation of sleep-wake rhythms. Read More

Compr Psychoneuroendocrinol 2021 Aug 27;7:100051. Epub 2021 Mar 27.

Biopsychology, Technische Universität Dresden, Andreas Schubert Bau, Dresden, Germany.

For poor sleep quality (SQ) as well as major depressive disorder (MDD) and burnout, a dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been identified. Although poor SQ is often reported as an early symptom of MDD or burnout, it is not clear whether HPA axis-related hormones can influence the association between SQ and MDD or burnout. This manuscript addresses this question by examining HPA axis-related hormones as potential moderators influencing the association between SQ and MDD or burnout. Read More

Psychol Res Behav Manag 2022 20;15:1545-1557. Epub 2022 Jun 20.

Saudi Board of Preventive Medicine, Ministry of Health, Makkah, Saudi Arabia.

Purpose: To examine the effect of long working hours on anxiety and depression among resident physicians working in Makkah, Saudi Arabia.

Methods: This is a cross-sectional study using an anonymous and confidential self-administered electronic questionnaire. Mental health status (depression and anxiety) is measured using hospital anxiety and depression scale. Read More

Front Neurol 2022 10;13:902637. Epub 2022 Jun 10.

Department of Neurology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czechia.

Aims Of The Study: Commonly used approach to illness assessment focuses on the patient's actual state supplemented by binary records of past events and conditions. This research project was designed to explain subjective experience in idiopathic hypersomnia (IH) patients influenced by their clinical symptoms and comorbidities.

Material And Methods: Forty-three IH patients of both sexes (female 60. Read More

Front Neurol 2022 10;13:880583. Epub 2022 Jun 10.

Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

REM sleep behavior disorder (RBD) is closely associated with Parkinson's disease (PD), however, the influence of dopaminergic replacement therapy (DRT) on the clinical course of RBD in PD remains less understood. The objective of our study is to investigate how DRTs modify the evolution of RBD in a longitudinal cohort study of initially PD patients. Four hundred and five drug-naive patients with early-stage PD were included. Read More

Clin Kidney J 2022 Jul 25;15(7):1290-1299. Epub 2022 Feb 25.

Internal Medicine Services, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland.

Background: Information on the incidence of chronic kidney disease (CKD) in the general population is scarce. This study examined the incidence and risk factors of CKD stages 1-5 in Iceland, based on multiple markers of kidney damage.

Methods: All serum creatinine (SCr) values, urine protein measurements and diagnosis codes for kidney diseases and comorbid conditions for people aged ≥18 years were obtained from electronic medical records of all healthcare institutions in Iceland in 2008-2016. Read More