1,305 results match your criteria Sleep Disorder Geriatric


Potentially Inappropriate Medications in Chinese Older Outpatients in tertiary hospitals according to Beers Criteria: A Cross-sectional Study.

Int J Clin Pract 2021 May 10:e14348. Epub 2021 May 10.

Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, China.

Objectives: Multimorbidity and polypharmacy in older adults always increase the prevalence of potentially inappropriate medications (PIMs) and affect the quality of life of older adults. Currently, the data of PIMs on Chinese geriatric outpatients based on Beers criteria 2015 and 2019 has not been studied. The purposes of this study were aimed to investigate the prevalence of PIMs prescription and the most frequent PIMs among outpatients according to the two criteria, and to explore related risk factors for PIMs. Read More

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Association of Structural Magnetic Resonance Imaging Measures With Psychosis Onset in Individuals at Clinical High Risk for Developing Psychosis: An ENIGMA Working Group Mega-analysis.

JAMA Psychiatry 2021 May 5. Epub 2021 May 5.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.

Importance: The ENIGMA clinical high risk (CHR) for psychosis initiative, the largest pooled neuroimaging sample of individuals at CHR to date, aims to discover robust neurobiological markers of psychosis risk.

Objective: To investigate baseline structural neuroimaging differences between individuals at CHR and healthy controls as well as between participants at CHR who later developed a psychotic disorder (CHR-PS+) and those who did not (CHR-PS-).

Design, Setting, And Participants: In this case-control study, baseline T1-weighted magnetic resonance imaging (MRI) data were pooled from 31 international sites participating in the ENIGMA Clinical High Risk for Psychosis Working Group. Read More

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Detection of Motor Dysfunction With Wearable Sensors in Patients With Idiopathic Rapid Eye Movement Disorder.

Front Bioeng Biotechnol 2021 15;9:627481. Epub 2021 Apr 15.

Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics, Beijing, China.

Patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) are at high risk for conversion to synucleinopathy and Parkinson disease (PD). This can potentially be monitored by measuring gait characteristics of iRBD patients, although quantitative data are scarce and previous studies have reported inconsistent findings. This study investigated subclinical gait changes in polysomnography-proven iRBD patients compared to healthy controls (HCs) during 3 different walking conditions using wearable motor sensors in order to determine whether gait changes can be detected in iRBD patients that could reflect early symptoms of movement disorder. Read More

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A Case of Lung Cancer with Brain Metastasis following Late-Onset Bipolar Disorder.

Behav Neurol 2021 1;2021:8880539. Epub 2021 Apr 1.

Department of Psychiatry, Chang Gung Memorial Hospital at Linkou, 333 Taoyuan, Taiwan.

Objective: To describe a case of lung cancer with brain metastasis in a patient who developed new late-onset bipolar disorder 2 years previously.

Background: The typical onset age of bipolar disorder is approximately 20, and the first episode is usually a depressive episode. It is still not clear which age-specific factors contribute to the underlying risk. Read More

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Severe urticarial rash as the initial symptom of COVID-19 infection.

BMJ Case Rep 2021 Mar 25;14(3). Epub 2021 Mar 25.

Department of Medicine, Division of Hospital Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.

A 54-year-old woman presented with pruritic rash and hives of 3 days' duration followed by shortness of breath for 1 day. SARS-CoV-2 PCR test for COVID-19 was positive. Cutaneous manifestations of COVID-19 include acral lesions, urticarial rash, erythematous maculopapular rash, vascular rashes and vesicular rash. Read More

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Prevalence of the core clinical features and the other neuropsychiatric symptoms in dementia with Lewy bodies.

Psychogeriatrics 2021 May 23;21(3):443-445. Epub 2021 Mar 23.

Department of Geriatric Neurology, Shiga General Hospital, Moriyama, Japan.

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Motoric Subtypes of Delirium and Long-Term Functional and Mental Health Outcomes in Adults After Critical Illness.

Crit Care Med 2021 May;49(5):e521-e532

Critical Illness, Brain Dysfunction, and Survivorship (CIBS) Center and the Center for Health Services Research, Vanderbilt University Medical Center, Nashville, TN.

Objectives: Adult ICU survivors that experience delirium are at high risk for developing new functional disabilities and mental health disorders. We sought to determine if individual motoric subtypes of delirium are associated with worse disability, depression, and/or post-traumatic stress disorder in ICU survivors.

Design: Secondary analysis of a prospective multicenter cohort study. Read More

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Taiwanese Depression Questionnaire and AD8 Questionnaire for Screening Late-Life Depression in Communities.

Neuropsychiatr Dis Treat 2021 9;17:747-755. Epub 2021 Mar 9.

Community Medicine Research Center, Chang Gung Memorial Hospital, Keelung, Taiwan.

Background: Major depressive disorder (MDD) presents with emotional and somatic symptoms and sometimes subjective cognitive complaints (SCCs). This study developed a collaborative method to integrate SCC assessment for evaluating late-life MDD.

Methods: Residents aged >50 years in the Community Medicine Research Center of Keelung Chang Gung Memorial Hospital in Taiwan during 2017-2018 were prospectively recruited in this study. Read More

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Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry.

Am J Hum Genet 2021 04 12;108(4):564-582. Epub 2021 Mar 12.

The Charles R. Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Although many loci have been associated with height in European ancestry populations, very few have been identified in African ancestry individuals. Furthermore, many of the known loci have yet to be generalized to and fine-mapped within a large-scale African ancestry sample. We performed sex-combined and sex-stratified meta-analyses in up to 52,764 individuals with height and genome-wide genotyping data from the African Ancestry Anthropometry Genetics Consortium (AAAGC). Read More

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Insomnia and falls in older adults: are they linked to executive dysfunction?

Psychogeriatrics 2021 May 8;21(3):359-367. Epub 2021 Mar 8.

Division of Geriatric Medicine, Department of Internal Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Background: Insomnia increases the incidence of falls and impairs executive function. Moreover, falls are associated with executive function impairment. The relationship between falls and executive function in patients with insomnia is not clear. Read More

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Sleep duration and timing are nonlinearly associated with depressive symptoms among older adults.

Sleep Med 2021 May 10;81:93-97. Epub 2021 Feb 10.

Department of Health Promotion and Health Education, National Taiwan Normal University, Taiwan; Faculty of Sport Sciences, Waseda University, Japan. Electronic address:

Background: Geriatric depression is a common but preventable psychiatric disorder; however, its association with specific sleep patterns remains unclear. Therefore, we examined the association of self-reported sleep duration and sleep timing with depressive symptoms in the older population.

Methods: A total of 1068 older Taiwanese adults (52. Read More

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Non-Motor Fluctuations in Parkinson's Disease: Validation of the Non-Motor Fluctuation Assessment Questionnaire.

Mov Disord 2021 Feb 15. Epub 2021 Feb 15.

James J. and Joan A. Gardner Center for Parkinson's Disease and Movement Disorders Department of Neurology, University of Cincinnati, Cincinnati, Ohio, USA.

Background: In patients with Parkinson's disease (PD), sleep, mood, cognitive, autonomic, and other non-motor symptoms may fluctuate in a manner similar to motor symptoms.

Objectives: To validate a final version of a patient-rated questionnaire that captures the presence and severity of non-motor fluctuations in levodopa-treated PD patients (NoMoFA).

Methods: We recruited PD subjects from five movement disorders centers across the US and Canada. Read More

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February 2021

Synergistic efficacy and diminished adverse effect profile of composite treatment of several ADHD medications.

Neuropharmacology 2021 04 12;187:108494. Epub 2021 Feb 12.

School of Medicine and Center for Neuroscience Research, Konkuk University, Seoul, 05029, Republic of Korea; TriNeuro Inc., 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea. Electronic address:

Although attention-deficit/hyperactivity disorder (ADHD) is widely studied, problems regarding the adverse effect risks and non-responder problems still need to be addressed. Combination pharmacotherapy using standard dose regimens of existing medication is currently being practiced mainly to augment the therapeutic efficacy of each drug. The idea of combining different pharmacotherapies with different molecular targets to alleviate the symptoms of ADHD and its comorbidities requires scientific evidence, necessitating the investigation of their therapeutic efficacy and the mechanisms underlying the professed synergistic effects. Read More

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The Association Between REM Sleep Behavior Disorder and Autonomic Dysfunction in Parkinson's Disease.

J Parkinsons Dis 2021 ;11(2):747-755

Department of Geriatric Medicine, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: REM behavior disorder (RBD) can occur in the context of neurodegenerative alpha-synucleinopathies, such as Parkinson's disease (PD). PD patients with RBD (PD-pRBD) represent more severe symptoms and signs compared with those without RBD (PD-nRBD). On another note, autonomic dysfunction in PD patients is categorized as one of the most prominent non-motor symptoms and has been lately the field of interest in research. Read More

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January 2021

Machine learning for image-based detection of patients with obstructive sleep apnea: an exploratory study.

Sleep Breath 2021 Feb 8. Epub 2021 Feb 8.

Rist Inc., Kyoto, Japan.

Purpose: In 2-dimensional lateral cephalometric radiographs, patients with severe obstructive sleep apnea (OSA) exhibit a more crowded oropharynx in comparison with non-OSA. We tested the hypothesis that machine learning, an application of artificial intelligence (AI), could be used to detect patients with severe OSA based on 2-dimensional images.

Methods: A deep convolutional neural network was developed (n = 1258; 90%) and tested (n = 131; 10%) using data from 1389 (100%) lateral cephalometric radiographs obtained from individuals diagnosed with severe OSA (n = 867; apnea hypopnea index > 30 events/h sleep) or non-OSA (n = 522; apnea hypopnea index < 5 events/h sleep) at a single center for sleep disorders. Read More

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February 2021

Modifiable Comorbidities Associated with Cognitive Decline in Parkinson's Disease.

Mov Disord Clin Pract 2021 Feb 20;8(2):254-263. Epub 2021 Jan 20.

Parkinson's Disease Research, Education and Clinical Center, Michael J. Crescenz Veterans Affairs Medical Center Philadelphia Pennsylvania USA.

Background: Cognitive impairment (CI) is one of the most feared and debilitating complications of PD. No therapy has been shown to slow or prevent CI in PD.

Objective: To determine associations between modifiable comorbidities, including cardiovascular disease risk factors, mood disorders, and sleep characteristics, and rate of cognitive decline in Parkinson's disease (PD). Read More

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February 2021

Status of clinical research in neurology in Germany-A national survey.

Eur J Neurol 2021 May 26;28(5):1446-1452. Epub 2021 Feb 26.

Department of Neurology with the Institute of Translational Neurology, University Hospital Münster, Münster, Germany.

Background And Purpose: To provide an overview on the status of clinical research in neurology in Germany.

Methods: German university hospitals, nonuniversity hospitals, and neurological medical practices were surveyed regarding their clinical research activities during the period 2013 to 2017.

Results: Fifty percent of university hospitals, 10. Read More

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The Association between Symptoms of Nomophobia, Insomnia and Food Addiction among Young Adults: Findings of an Exploratory Cross-Sectional Survey.

Int J Environ Res Public Health 2021 01 15;18(2). Epub 2021 Jan 15.

Psychiatry & Behavioral Sciences, Gerontology & Geriatric Medicine, and Biobehavioral Nursing, University of Washington, Seattle, WA 98195-6560, USA.

No previous research has examined the association between symptoms of nomophobia and food addiction. Similarly, only a few studies have examined the association between nomophobia and symptoms of insomnia. This exploratory study utilized an online self-administered, structured questionnaire that included: basic sociodemographic and anthropometrics; the nomophobia questionnaire (NMP-Q); the insomnia severity index (ISI); and the Yale Food Addiction Scale (YFAS) in a convenience sample of young adults (18-35 years) in Bahrain ( = 654), 304 (46%) males and 350 (54%) females. Read More

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January 2021

A Model of Adolescent Sleep Health and Risk for Type 2 Diabetes.

Curr Diab Rep 2021 01 15;21(2). Epub 2021 Jan 15.

University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Purpose Of Review: This paper presents a review of the current literature in support of a model explaining the relationships between sleep health and risk for type 2 diabetes in adolescents.

Recent Findings: Short sleep duration is associated with risk of developing obesity in youth. Sleep restriction increases energy expenditure, but also increases hunger, appetite, and food intake, causing positive energy balance, impacting appetite-regulating hormones, and leading to increased eating late at night. Read More

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January 2021

[Nonmotor symptoms in 32 patients with Parkinson disease].

Rev Med Chil 2020 Aug;148(8):1075-1082

Centro de Trastornos del Movimiento, Santiago, Chile.

Background: Nonmotor symptoms of Parkinson disease significantly hamper the quality of life of patients and have prognostic significance.

Aim: To evaluate the presence of nonmotor symptoms in patients with Parkinson disease.

Material And Methods: A structured interview was carried out in 32 patients aged 74 ± 9 years (53% men) with Parkinson disease asking specifically for impulse control disorders and dopaminergic dysregulation. Read More

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Home-EEG assessment of possible compensatory mechanisms for sleep disruption in highly irregular shift workers - The ANCHOR study.

PLoS One 2020 31;15(12):e0237622. Epub 2020 Dec 31.

Department of Geriatric Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

Study Objectives: While poor sleep quality has been related to increased risk of Alzheimer's disease, long-time shift workers (maritime pilots) did not manifest evidence of early Alzheimer's disease in a recent study. We explored two hypotheses of possible compensatory mechanisms for sleep disruption: Increased efficiency in generating deep sleep during workweeks (model 1) and rebound sleep during rest weeks (model 2).

Methods: We used data from ten male maritime pilots (mean age: 51. Read More

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January 2021

Moving More and Sitting Less as Healthy Lifestyle Behaviors are Protective Factors for Insomnia, Depression, and Anxiety Among Adolescents During the COVID-19 Pandemic.

Psychol Res Behav Manag 2020 17;13:1223-1233. Epub 2020 Dec 17.

Exercise and Mental Health Laboratory, Shenzhen University, Shenzhen 518060, People's Republic of China.

Purpose: This study aimed to investigate associations of physical activity time (PAT) and sitting time (ST) independently and jointly with insomnia, depressive and anxiety symptoms among Chinese adolescents in the context of COVID-19.

Methods: A cross-sectional study including 965 adolescents (mean age = 15.26, SD = 0. Read More

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December 2020

Hypomethylation of SNCA in Idiopathic REM Sleep Behavior Disorder Associated With Phenoconversion.

Mov Disord 2021 Apr 19;36(4):955-962. Epub 2020 Dec 19.

Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China.

Background: Hypomethylation of intron 1 of the α-synuclein (SNCA) gene has been extensively reported in the blood of patients with α-synucleinopathies. Idiopathic rapid eye movement sleep behavior disorder represents a prodromal stage of α-synucleinopathies. Methylation of α-synuclein intron 1 in idiopathic rapid eye movement sleep behavior disorder patients is largely unexplored. Read More

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Rheostatic Balance of Circadian Rhythm and Autophagy in Metabolism and Disease.

Front Cell Dev Biol 2020 24;8:616434. Epub 2020 Nov 24.

Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.

Circadian rhythms are physical, behavioral and environmental cycles that respond primarily to light and dark, with a period of time of approximately 24 h. The most essential physiological functions of mammals are manifested in circadian rhythm patterns, including the sleep-wake cycle and nutrient and energy metabolism. Autophagy is a conserved biological process contributing to nutrient and cellular homeostasis. Read More

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November 2020

The Effect of Pain Catastrophizing on Depression among Older Korean Adults with Chronic Pain: The Mediating Role of Chronic Pain Interference and Sleep Quality.

Int J Environ Res Public Health 2020 11 24;17(23). Epub 2020 Nov 24.

College of Nursing, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul 03080, Korea.

Pain catastrophizing is a notable concept associated with change in chronic pain interference and depression. Sleep quality is also one of the important factors affecting geriatric depression. This study examined the mediating effects of chronic pain interference and sleep quality on the relationship between pain catastrophizing and depression. Read More

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November 2020

Insomnia Precipitating Events among Women Veterans: The Impact of Traumatic and Nontraumatic Events on Sleep and Mental Health Symptoms.

Behav Sleep Med 2020 Nov 30:1-17. Epub 2020 Nov 30.

Geriatric Research, Education and Clinical Center, VA Greater Los Angeles Healthcare System, Los Angeles, California.

: The current study describes insomnia precipitating events reported by women Veterans and examines differences in sleep and psychological distress variables in those who endorsed traumatic, nontraumatic, or no insomnia precipitating events.: Baseline data were collected from 347 women Veterans enrolled in a behavioral sleep intervention study (NCT02076165). : Participants completed self-report measures of insomnia symptoms, sleep quality, sleep efficiency (SE), nightmare frequency, and depression and posttraumatic stress disorder (PTSD) symptoms; SE was also assessed by wrist actigraphy. Read More

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November 2020

[Cardiac functional alterations and its risk factors in elderly patients with obstructive sleep apnea syndrome free of cardiovascular disease].

Nan Fang Yi Ke Da Xue Xue Bao 2020 Nov;40(11):1587-1592

Department of Pulmonary and Critical Care Medicine, General Hospital of PLA, Beijing 100853, China.

Objective: To evaluate the changes of cardiac structure and function and their risk factors in elderly patients with obstructive sleep apnea syndrome (OSA) without cardiovascular complications.

Methods: Eighty-two elderly OSA patients without cardiovascular disease admitted between January, 2015 and October, 2016 were enrolled in this study. According to their apnea-hypopnea index (AHI, calculated as the average number of episodes of apnoea and hypopnoea per hour of sleep), the patients were divided into mild OSA group (AHI < 15) and moderate to severe OSA group (AHI ≥ 15). Read More

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November 2020

Association Between REM Sleep Behavior Disorder and Cognitive Dysfunctions in Parkinson's Disease: A Systematic Review and Meta-Analysis of Observational Studies.

Front Neurol 2020 6;11:577874. Epub 2020 Nov 6.

Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.

Rapid eye movement sleep behavior disorder (RBD) is thought to be a prodromal symptom of Parkinson's disease (PD). RBD is also thought to be involved in cognitive decline and dementia in PD. In PD, although the relationship between RBD and cognitive dysfunctions was confirmed by considerable studies, whether RBD was associated with distinct types of cognitive defects is worth of study. Read More

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November 2020

Randomized controlled trial of an integrated approach to treating insomnia and improving the use of positive airway pressure therapy in veterans with comorbid insomnia disorder and obstructive sleep apnea.

Sleep 2021 04;44(4)

Geriatric Research, Education and Clinical Center (GRECC), VA Greater Los Angeles Healthcare System, Los Angeles, CA.

Study Objectives: Cognitive behavioral therapy for insomnia (CBTI) for comorbid insomnia and obstructive sleep apnea (OSA) has had mixed results. We integrated CBTI with a positive airway pressure (PAP) adherence program and tested effects on sleep and PAP use.

Methods: 125 veterans (mean age 63. Read More

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Innovations in Geroscience to enhance mobility in older adults.

Exp Gerontol 2020 12 22;142:111123. Epub 2020 Oct 22.

University of Florida, Department of Psychology, 945 Center Drive, Gainesville, FL 32611, United States. Electronic address:

Aging is the primary risk factor for functional decline; thus, understanding and preventing disability among older adults has emerged as an important public health challenge of the 21st century. The science of gerontology - or geroscience - has the practical purpose of "adding life to the years." The overall goal of geroscience is to increase healthspan, which refers to extending the portion of the lifespan in which the individual experiences enjoyment, satisfaction, and wellness. Read More

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December 2020