1,062 results match your criteria Sleep Disorder Geriatric


[The expressions of CTLA-4 and PD-1 on CD(4)(+) T cells and the level of plasma VEGF in patients with obstructive sleep apnea hypopnea syndrome].

Zhonghua Jie He He Hu Xi Za Zhi 2019 Apr;42(4):268-274

Department of Respiratory and Critical Care Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong Geriatric Institute, Guangzhou 510080, China.

CD(4)(+)T cells, cytotoxic T-lymphocyte antigen 4 (CTLA-4), programmed cell death-1 (PD-1) and vascular endothelial growth factor (VEGF) are associated with cancer development. The aim of the present study was to investigate the expression of CTLA-4, PD-1 and VEGF in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). From January 2017 to January 2018, a total of 47 first-visit outpatients were recruited in the Sleep and Respiratory Disorder Center of Guangdong Provincial People's Hospital, and were divided into control group (=17, mean age 54±12 years), mild-to-moderate OSAHS group (=15, mean age 54±12 years) and severe OSAHS group (=15, mean age 56±13 years). Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-0939.2019.04.004DOI Listing
April 2019
11 Reads

Overnight Urge Perception in Nocturia Is Independent of Depression, PTSD, or Anxiety in a Male Veterans Administration Population.

J Clin Sleep Med 2019 Apr 15;15(4):615-621. Epub 2019 Apr 15.

Department of Urology, SUNY Downstate Medical Center, Brooklyn, New York.

Study Objectives: The goal of this study was to compare the urge perception associated with nocturnal voiding at the time of voiding in individuals with and without depression, posttraumatic stress disorder (PTSD), or anxiety diagnoses to test the hypothesis that patients with such diagnoses are more likely to experience insomnia-driven convenience voiding during the sleep period.

Methods: A database of voiding diaries with urge perception grades (UPGs) from 429 adult males seeking treatment for nocturia at a Veterans Affairs-based urology clinic was analyzed. The UPG categorizes perception for urinating from 0 (out of convenience) to 4 (desperate urge). Read More

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http://dx.doi.org/10.5664/jcsm.7726DOI Listing
April 2019
4 Reads

Insomnia Disorder Among Older Veterans: Results of a Postal Survey.

J Clin Sleep Med 2019 Apr 15;15(4):543-551. Epub 2019 Apr 15.

David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California.

Study Objectives: To estimate the prevalence of insomnia disorder among older veterans and to study relationships among age and self-rated health, with insomnia disorder, self-reported sleep duration and sleep efficiency.

Methods: A cross-sectional postal survey of community-dwelling older veterans (older than 60 years) seen at one VA Healthcare System in the prior 18 months was performed, which was constructed to align with the general diagnostic criteria for insomnia disorder (International Classification of Sleep Disorders, Second Edition [ICSD-2]). The survey also queried self-reported sleep duration, bedtime, and wake time, which were used to calculate sleep efficiency. Read More

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http://dx.doi.org/10.5664/jcsm.7710DOI Listing
April 2019
10 Reads

Mild cognitive impairment in de novo Parkinson's disease: A neuromelanin MRI study in locus coeruleus.

Mov Disord 2019 Apr 2. Epub 2019 Apr 2.

Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China.

Background: We aimed to investigate neuromelanin-sensitive magnetic resonance imaging (NM-MRI) features in the locus coeruleus of de novo Parkinson's disease patients with different cognitive states and to determine whether these features are associated with cognitive impairment.

Methods: Three groups of subjects were recruited in this study, including patients with de novo PD with mild cognitive impairment (n = 23), patients with de novo PD without cognitive impairment (n = 48), and control subjects (n = 32). All subjects underwent clinical evaluations, as well as MRI scanning. Read More

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http://dx.doi.org/10.1002/mds.27682DOI Listing
April 2019
5 Reads

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.

Authors:
Amy R Bentley Yun J Sung Michael R Brown Thomas W Winkler Aldi T Kraja Ioanna Ntalla Karen Schwander Daniel I Chasman Elise Lim Xuan Deng Xiuqing Guo Jingmin Liu Yingchang Lu Ching-Yu Cheng Xueling Sim Dina Vojinovic Jennifer E Huffman Solomon K Musani Changwei Li Mary F Feitosa Melissa A Richard Raymond Noordam Jenna Baker Guanjie Chen Hugues Aschard Traci M Bartz Jingzhong Ding Rajkumar Dorajoo Alisa K Manning Tuomo Rankinen Albert V Smith Salman M Tajuddin Wei Zhao Mariaelisa Graff Maris Alver Mathilde Boissel Jin Fang Chai Xu Chen Jasmin Divers Evangelos Evangelou Chuan Gao Anuj Goel Yanick Hagemeijer Sarah E Harris Fernando P Hartwig Meian He Andrea R V R Horimoto Fang-Chi Hsu Yi-Jen Hung Anne U Jackson Anuradhani Kasturiratne Pirjo Komulainen Brigitte Kühnel Karin Leander Keng-Hung Lin Jian'an Luan Leo-Pekka Lyytikäinen Nana Matoba Ilja M Nolte Maik Pietzner Bram Prins Muhammad Riaz Antonietta Robino M Abdullah Said Nicole Schupf Robert A Scott Tamar Sofer Alena Stancáková Fumihiko Takeuchi Bamidele O Tayo Peter J van der Most Tibor V Varga Tzung-Dau Wang Yajuan Wang Erin B Ware Wanqing Wen Yong-Bing Xiang Lisa R Yanek Weihua Zhang Jing Hua Zhao Adebowale Adeyemo Saima Afaq Najaf Amin Marzyeh Amini Dan E Arking Zorayr Arzumanyan Tin Aung Christie Ballantyne R Graham Barr Lawrence F Bielak Eric Boerwinkle Erwin P Bottinger Ulrich Broeckel Morris Brown Brian E Cade Archie Campbell Mickaël Canouil Sabanayagam Charumathi Yii-Der Ida Chen Kaare Christensen Maria Pina Concas John M Connell Lisa de Las Fuentes H Janaka de Silva Paul S de Vries Ayo Doumatey Qing Duan Charles B Eaton Ruben N Eppinga Jessica D Faul James S Floyd Nita G Forouhi Terrence Forrester Yechiel Friedlander Ilaria Gandin He Gao Mohsen Ghanbari Sina A Gharib Bruna Gigante Franco Giulianini Hans J Grabe C Charles Gu Tamara B Harris Sami Heikkinen Chew-Kiat Heng Makoto Hirata James E Hixson M Arfan Ikram Yucheng Jia Roby Joehanes Craig Johnson Jost Bruno Jonas Anne E Justice Tomohiro Katsuya Chiea Chuen Khor Tuomas O Kilpeläinen Woon-Puay Koh Ivana Kolcic Charles Kooperberg Jose E Krieger Stephen B Kritchevsky Michiaki Kubo Johanna Kuusisto Timo A Lakka Carl D Langefeld Claudia Langenberg Lenore J Launer Benjamin Lehne Cora E Lewis Yize Li Jingjing Liang Shiow Lin Ching-Ti Liu Jianjun Liu Kiang Liu Marie Loh Kurt K Lohman Tin Louie Anna Luzzi Reedik Mägi Anubha Mahajan Ani W Manichaikul Colin A McKenzie Thomas Meitinger Andres Metspalu Yuri Milaneschi Lili Milani Karen L Mohlke Yukihide Momozawa Andrew P Morris Alison D Murray Mike A Nalls Matthias Nauck Christopher P Nelson Kari E North Jeffrey R O'Connell Nicholette D Palmer George J Papanicolau Nancy L Pedersen Annette Peters Patricia A Peyser Ozren Polasek Neil Poulter Olli T Raitakari Alex P Reiner Frida Renström Treva K Rice Stephen S Rich Jennifer G Robinson Lynda M Rose Frits R Rosendaal Igor Rudan Carsten O Schmidt Pamela J Schreiner William R Scott Peter Sever Yuan Shi Stephen Sidney Mario Sims Jennifer A Smith Harold Snieder John M Starr Konstantin Strauch Heather M Stringham Nicholas Y Q Tan Hua Tang Kent D Taylor Yik Ying Teo Yih Chung Tham Henning Tiemeier Stephen T Turner André G Uitterlinden Diana van Heemst Melanie Waldenberger Heming Wang Lan Wang Lihua Wang Wen Bin Wei Christine A Williams Gregory Wilson Mary K Wojczynski Jie Yao Kristin Young Caizheng Yu Jian-Min Yuan Jie Zhou Alan B Zonderman Diane M Becker Michael Boehnke Donald W Bowden John C Chambers Richard S Cooper Ulf de Faire Ian J Deary Paul Elliott Tõnu Esko Martin Farrall Paul W Franks Barry I Freedman Philippe Froguel Paolo Gasparini Christian Gieger Bernardo L Horta Jyh-Ming Jimmy Juang Yoichiro Kamatani Candace M Kammerer Norihiro Kato Jaspal S Kooner Markku Laakso Cathy C Laurie I-Te Lee Terho Lehtimäki Patrik K E Magnusson Albertine J Oldehinkel Brenda W J H Penninx Alexandre C Pereira Rainer Rauramaa Susan Redline Nilesh J Samani James Scott Xiao-Ou Shu Pim van der Harst Lynne E Wagenknecht Jun-Sing Wang Ya Xing Wang Nicholas J Wareham Hugh Watkins David R Weir Ananda R Wickremasinghe Tangchun Wu Eleftheria Zeggini Wei Zheng Claude Bouchard Michele K Evans Vilmundur Gudnason Sharon L R Kardia Yongmei Liu Bruce M Psaty Paul M Ridker Rob M van Dam Dennis O Mook-Kanamori Myriam Fornage Michael A Province Tanika N Kelly Ervin R Fox Caroline Hayward Cornelia M van Duijn E Shyong Tai Tien Yin Wong Ruth J F Loos Nora Franceschini Jerome I Rotter Xiaofeng Zhu Laura J Bierut W James Gauderman Kenneth Rice Patricia B Munroe Alanna C Morrison Dabeeru C Rao Charles N Rotimi L Adrienne Cupples

Nat Genet 2019 04 29;51(4):636-648. Epub 2019 Mar 29.

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Read More

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http://dx.doi.org/10.1038/s41588-019-0378-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467258PMC
April 2019
10 Reads
29.352 Impact Factor

Prevalence of Disagreement About Appropriateness of Treatment Between ICU Patients/Surrogates and Clinicians.

Chest 2019 Mar 26. Epub 2019 Mar 26.

Department of Intensive Care Medicine, Ghent University Hospital, Ghent, Belgium.

Background: ICU patients/surrogates may experience adverse outcomes related to perceived inappropriate treatment. The objective was to determine the prevalence of patient/surrogate-reported perceived inappropriate treatment, its impact on adverse outcomes, and discordance with clinicians.

Methods: We conducted a multicenter, prospective, observational study of adult ICU patients. Read More

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http://dx.doi.org/10.1016/j.chest.2019.02.404DOI Listing
March 2019
1 Read
7.483 Impact Factor

The goddess who spins the thread of life: Klotho, psychiatric stress, and accelerated aging.

Brain Behav Immun 2019 Mar 11. Epub 2019 Mar 11.

National Center for PTSD at VA Boston Healthcare System, Boston, MA, USA; Boston University School of Medicine, Department of Psychiatry, Boston, MA, USA.

Background: Longevity gene klotho (KL) is associated with age-related phenotypes but has not been evaluated against a direct human biomarker of cellular aging. We examined KL and psychiatric stress, including posttraumatic stress disorder (PTSD), which is thought to potentiate accelerated aging, in association with biomarkers of cellular aging.

Methods: The sample comprised 309 white, non-Hispanic genotyped veterans with measures of epigenetic age (DNA methylation age), telomere length (n = 252), inflammation (C-reactive protein), psychiatric symptoms, metabolic function, and white matter neural integrity (diffusion tensor imaging; n = 185). Read More

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http://dx.doi.org/10.1016/j.bbi.2019.03.007DOI Listing
March 2019
3 Reads

Clinical Features and Correlates of Excessive Daytime Sleepiness in Parkinson's Disease.

Front Neurol 2019 19;10:121. Epub 2019 Feb 19.

Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.

To explore the clinical features and correlates of excessive daytime sleepiness (EDS) in a Chinese population of Parkinson's disease (PD) patients. Patients with clinically established or clinically probable PD were recruited. Clinical and demographic data were collected, and participants were evaluated using standardized assessment protocols. Read More

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http://dx.doi.org/10.3389/fneur.2019.00121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389626PMC
February 2019
5 Reads

Noninvasive Ventilation: Education and Training. A Narrative Analysis and an International Consensus Document.

Adv Respir Med 2019 Mar 4. Epub 2019 Mar 4.

Intensive Care Unit. Hospital Morales Meseguer Murcia, Murcia, 30008, Spain.

Background: Noninvasive ventilation (NIV) is an increasingly used method of respiratory support. The use of the NIV is expanding over the time and if properly used, it can save patients life and improve long-term prognosis. However, both knowledge and skills for its proper use as a life-support are paramount. Read More

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http://dx.doi.org/10.5603/ARM.a2019.0006DOI Listing
March 2019
4 Reads

Prevalence of mental illness and their association with sociodemographic factors in the rural geriatric population in Chittoor, Andhra Pradesh, India: A community-based study.

J Educ Health Promot 2018 28;7:165. Epub 2018 Dec 28.

Department of Community Medicine, Apollo Institute of Medical Sciences and Research, Chittoor, Andhra Pradesh, India.

Background: Mental health problems such as cognitive impairment, depression, anxiety, and sleep disorders arising out of senility, neurosis, and living conditions are common in the geriatric population.

Objective: The objective of this study was to estimate the prevalence of mental illness and to describe their sociodemographic factors in the rural geriatric population and see their association with other factors.

Methodology: A community-based cross-sectional study was done on individuals aged more than 60 years. Read More

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http://dx.doi.org/10.4103/jehp.jehp_193_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333028PMC
December 2018
1 Read

Prevalence of Depression in an Urban Geriatric Population in Marathwada Region of Western India.

Indian J Psychol Med 2019 Jan-Feb;41(1):32-37

Department of Community Medicine, Government Medical College, Vidisha, Madhya Pradesh, India.

Background: Depression is a common problem in the elderly but is often undetected and ignored as a medical problem, leading to poor quality of life. This community-based study was conducted to know the burden and risk factors of depression among the elderly.

Subjects And Methods: The survey was done in 2015 in Maharashtra, India as a part of an initiative addressing community mental health needs of the elderly. Read More

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http://dx.doi.org/10.4103/IJPSYM.IJPSYM_234_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337928PMC
February 2019
1 Read

Relationship of Nocturnal Sleep Dysfunction and Pain Subtypes in Parkinson's Disease.

Mov Disord Clin Pract 2019 Jan 8;6(1):57-64. Epub 2018 Nov 8.

Institute of Psychiatry, Psychology, & Neuroscience at King's College and King's College Hospital NHS Foundation Trust London United Kingdom.

Background: Little research has been conducted regarding the relationship between sleep disorders and different pain types in Parkinson's disease (PD).

Objective: To explore the influence of the various pain subtypes experienced by PD patients on sleep.

Methods: Three hundred consecutive PD patients were assessed with the PD Sleep Scale-Version 2 (PDSS-2), King's PD Pain Scale (KPPS), King's PD Pain Questionnaire (KPPQ), Visual Analog Scales for Pain (VAS-Pain), and Hospital Anxiety and Depression Scale. Read More

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http://dx.doi.org/10.1002/mdc3.12694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335509PMC
January 2019
2 Reads

Comparison of Quantitative Electroencephalogram During Sleep in Depressed and Non-Depressed Patients with Parkinson's Disease.

Med Sci Monit 2019 Feb 7;25:1046-1052. Epub 2019 Feb 7.

Department of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China (mainland).

BACKGROUND Depression is one of the most important factors affecting quality of life in Parkinson's patients. Most research on Parkinson's disease with depression has focused on neuroimaging, and there have been few quantitative electroencephalogram studies. Sleep is a biomarker for depression; therefore, the aim of this study was to identify differences in quantitative electroencephalograms during sleep in depressed and non-depressed patients with Parkinson's disease. Read More

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http://dx.doi.org/10.12659/MSM.913931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375285PMC
February 2019
2 Reads

Improved understanding, detection, and management of neuropsychiatric complications: essential components to the optimal treatment of Parkinson's disease.

Int Psychogeriatr 2019 Jan;31(1):1-4

Rutgers,The State University of New Jersey,Robert Wood Johnson Medical School,Piscataway,NJ,USA.

It has been well established that Parkinson's disease (PD) is not just a movement disorder (Weintraub and Burn, 2011). Fortunately, the past two decades have seen increased attention to the neuropsychiatric aspects of the disease process. Neuropsychiatric symptoms (e. Read More

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http://dx.doi.org/10.1017/S1041610219000048DOI Listing
January 2019
1 Read

Effects of Brief Cognitive Behavioral Therapy for Insomnia on Improving Depression Among Community-Dwelling Older Adults: A Randomized Controlled Comparative Study.

Worldviews Evid Based Nurs 2019 Feb 3;16(1):78-86. Epub 2019 Feb 3.

Kitasato University Graduate School of Medical Sciences, Kanagawa, Japan.

Background: Cognitive behavioral therapy for insomnia (CBT-I) has been shown to improve depressive symptoms in older adults with comorbid insomnia and depression. However, it remains unclear whether brief CBT-I is effective for improving depressive symptoms in community-dwelling older adults with insomnia symptoms of varying severity.

Aim: This study sought to examine the effectiveness of a brief CBT-I intervention delivered by public health nurses to improve depressive symptoms among older adults recruited from a community setting. Read More

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http://dx.doi.org/10.1111/wvn.12342DOI Listing
February 2019
2 Reads

Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions.

Authors:
Paul S de Vries Michael R Brown Amy R Bentley Yun J Sung Thomas W Winkler Ioanna Ntalla Karen Schwander Aldi T Kraja Xiuqing Guo Nora Franceschini Ching-Yu Cheng Xueling Sim Dina Vojinovic Jennifer E Huffman Solomon K Musani Changwei Li Mary F Feitosa Melissa A Richard Raymond Noordam Hugues Aschard Traci M Bartz Lawrence F Bielak Xuan Deng Rajkumar Dorajoo Kurt K Lohman Alisa K Manning Tuomo Rankinen Albert V Smith Salman M Tajuddin Evangelos Evangelou Mariaelisa Graff Maris Alver Mathilde Boissel Jin Fang Chai Xu Chen Jasmin Divers Ilaria Gandin Chuan Gao Anuj Goel Yanick Hagemeijer Sarah E Harris Fernando P Hartwig Meian He Andrea R V R Horimoto Fang-Chi Hsu Anne U Jackson Anuradhani Kasturiratne Pirjo Komulainen Brigitte Kühnel Federica Laguzzi Joseph H Lee Jian'an Luan Leo-Pekka Lyytikäinen Nana Matoba Ilja M Nolte Maik Pietzner Muhammad Riaz M Abdullah Said Robert A Scott Tamar Sofer Alena Stancáková Fumihiko Takeuchi Bamidele O Tayo Peter J van der Most Tibor V Varga Yajuan Wang Erin B Ware Wanqing Wen Lisa R Yanek Weihua Zhang Jing Hua Zhao Saima Afaq Najaf Amin Marzyeh Amini Dan E Arking Tin Aung Christie Ballantyne Eric Boerwinkle Ulrich Broeckel Archie Campbell Mickaël Canouil Sabanayagam Charumathi Yii-Der Ida Chen John M Connell Ulf de Faire Lisa de Las Fuentes Renée de Mutsert H Janaka de Silva Jingzhong Ding Anna F Dominiczak Qing Duan Charles B Eaton Ruben N Eppinga Jessica D Faul Virginia Fisher Terrence Forrester Oscar H Franco Yechiel Friedlander Mohsen Ghanbari Franco Giulianini Hans J Grabe Megan L Grove C Charles Gu Tamara B Harris Sami Heikkinen Chew-Kiat Heng Makoto Hirata James E Hixson Barbara V Howard M Arfan Ikram David R Jacobs Craig Johnson Jost Bruno Jonas Candace M Kammerer Tomohiro Katsuya Chiea Chuen Khor Tuomas O Kilpeläinen Woon-Puay Koh Heikki A Koistinen Ivana Kolcic Charles Kooperberg Jose E Krieger Steve B Kritchevsky Michiaki Kubo Johanna Kuusisto Timo A Lakka Carl D Langefeld Claudia Langenberg Lenore J Launer Benjamin Lehne Rozenn N Lemaitre Yize Li Jingjing Liang Jianjun Liu Kiang Liu Marie Loh Tin Louie Reedik Mägi Ani W Manichaikul Colin A McKenzie Thomas Meitinger Andres Metspalu Yuri Milaneschi Lili Milani Karen L Mohlke Thomas H Mosley Kenneth J Mukamal Mike A Nalls Matthias Nauck Christopher P Nelson Nona Sotoodehnia Jeff R O'Connell Nicholette D Palmer Raha Pazoki Nancy L Pedersen Annette Peters Patricia A Peyser Ozren Polasek Neil Poulter Leslie J Raffel Olli T Raitakari Alex P Reiner Treva K Rice Stephen S Rich Antonietta Robino Jennifer G Robinson Lynda M Rose Igor Rudan Carsten O Schmidt Pamela J Schreiner William R Scott Peter Sever Yuan Shi Stephen Sidney Mario Sims Blair H Smith Jennifer A Smith Harold Snieder John M Starr Konstantin Strauch Nicholas Tan Kent D Taylor Yik Ying Teo Yih Chung Tham André G Uitterlinden Diana van Heemst Dragana Vuckovic Melanie Waldenberger Lihua Wang Yujie Wang Zhe Wang Wen Bin Wei Christine Williams Gregory Wilson Mary K Wojczynski Jie Yao Bing Yu Caizheng Yu Jian-Min Yuan Wei Zhao Alan B Zonderman Diane M Becker Michael Boehnke Donald W Bowden John C Chambers Ian J Deary Tõnu Esko Martin Farrall Paul W Franks Barry I Freedman Philippe Froguel Paolo Gasparini Christian Gieger Bernardo L Horta Yoichiro Kamatani Norihiro Kato Jaspal S Kooner Markku Laakso Karin Leander Terho Lehtimäki Patrik K E Magnusson Brenda Penninx Alexandre C Pereira Rainer Rauramaa Nilesh J Samani James Scott Xiao-Ou Shu Pim van der Harst Lynne E Wagenknecht Ya Xing Wang Nicholas J Wareham Hugh Watkins David R Weir Ananda R Wickremasinghe Wei Zheng Paul Elliott Kari E North Claude Bouchard Michele K Evans Vilmundur Gudnason Ching-Ti Liu Yongmei Liu Bruce M Psaty Paul M Ridker Rob M van Dam Sharon L R Kardia Xiaofeng Zhu Charles N Rotimi Dennis O Mook-Kanamori Myriam Fornage Tanika N Kelly Ervin R Fox Caroline Hayward Cornelia M van Duijn E Shyong Tai Tien Yin Wong Jingmin Liu Jerome I Rotter W James Gauderman Michael A Province Patricia B Munroe Kenneth Rice Daniel I Chasman L Adrienne Cupples Dabeeru C Rao Alanna C Morrison

Am J Epidemiol 2019 Jan 29. Epub 2019 Jan 29.

Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas.

An individual's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multi-ancestry genome-wide association study of levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. We included 45 studies in Stage 1 (genome-wide discovery) and 66 studies in Stage 2 (focused follow-up), for a total of 394,584 individuals from five ancestry groups. Read More

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https://academic.oup.com/aje/advance-article/doi/10.1093/aje
Publisher Site
http://dx.doi.org/10.1093/aje/kwz005DOI Listing
January 2019
24 Reads
5.230 Impact Factor

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.

Authors:
Tuomas O Kilpeläinen Amy R Bentley Raymond Noordam Yun Ju Sung Karen Schwander Thomas W Winkler Hermina Jakupović Daniel I Chasman Alisa Manning Ioanna Ntalla Hugues Aschard Michael R Brown Lisa de Las Fuentes Nora Franceschini Xiuqing Guo Dina Vojinovic Stella Aslibekyan Mary F Feitosa Minjung Kho Solomon K Musani Melissa Richard Heming Wang Zhe Wang Traci M Bartz Lawrence F Bielak Archie Campbell Rajkumar Dorajoo Virginia Fisher Fernando P Hartwig Andrea R V R Horimoto Changwei Li Kurt K Lohman Jonathan Marten Xueling Sim Albert V Smith Salman M Tajuddin Maris Alver Marzyeh Amini Mathilde Boissel Jin Fang Chai Xu Chen Jasmin Divers Evangelos Evangelou Chuan Gao Mariaelisa Graff Sarah E Harris Meian He Fang-Chi Hsu Anne U Jackson Jing Hua Zhao Aldi T Kraja Brigitte Kühnel Federica Laguzzi Leo-Pekka Lyytikäinen Ilja M Nolte Rainer Rauramaa Muhammad Riaz Antonietta Robino Rico Rueedi Heather M Stringham Fumihiko Takeuchi Peter J van der Most Tibor V Varga Niek Verweij Erin B Ware Wanqing Wen Xiaoyin Li Lisa R Yanek Najaf Amin Donna K Arnett Eric Boerwinkle Marco Brumat Brian Cade Mickaël Canouil Yii-Der Ida Chen Maria Pina Concas John Connell Renée de Mutsert H Janaka de Silva Paul S de Vries Ayşe Demirkan Jingzhong Ding Charles B Eaton Jessica D Faul Yechiel Friedlander Kelley P Gabriel Mohsen Ghanbari Franco Giulianini Chi Charles Gu Dongfeng Gu Tamara B Harris Jiang He Sami Heikkinen Chew-Kiat Heng Steven C Hunt M Arfan Ikram Jost B Jonas Woon-Puay Koh Pirjo Komulainen Jose E Krieger Stephen B Kritchevsky Zoltán Kutalik Johanna Kuusisto Carl D Langefeld Claudia Langenberg Lenore J Launer Karin Leander Rozenn N Lemaitre Cora E Lewis Jingjing Liang Jianjun Liu Reedik Mägi Ani Manichaikul Thomas Meitinger Andres Metspalu Yuri Milaneschi Karen L Mohlke Thomas H Mosley Alison D Murray Mike A Nalls Ei-Ei Khaing Nang Christopher P Nelson Sotoodehnia Nona Jill M Norris Chiamaka Vivian Nwuba Jeff O'Connell Nicholette D Palmer George J Papanicolau Raha Pazoki Nancy L Pedersen Annette Peters Patricia A Peyser Ozren Polasek David J Porteous Alaitz Poveda Olli T Raitakari Stephen S Rich Neil Risch Jennifer G Robinson Lynda M Rose Igor Rudan Pamela J Schreiner Robert A Scott Stephen S Sidney Mario Sims Jennifer A Smith Harold Snieder Tamar Sofer John M Starr Barbara Sternfeld Konstantin Strauch Hua Tang Kent D Taylor Michael Y Tsai Jaakko Tuomilehto André G Uitterlinden M Yldau van der Ende Diana van Heemst Trudy Voortman Melanie Waldenberger Patrik Wennberg Gregory Wilson Yong-Bing Xiang Jie Yao Caizheng Yu Jian-Min Yuan Wei Zhao Alan B Zonderman Diane M Becker Michael Boehnke Donald W Bowden Ulf de Faire Ian J Deary Paul Elliott Tõnu Esko Barry I Freedman Philippe Froguel Paolo Gasparini Christian Gieger Norihiro Kato Markku Laakso Timo A Lakka Terho Lehtimäki Patrik K E Magnusson Albertine J Oldehinkel Brenda W J H Penninx Nilesh J Samani Xiao-Ou Shu Pim van der Harst Jana V Van Vliet-Ostaptchouk Peter Vollenweider Lynne E Wagenknecht Ya X Wang Nicholas J Wareham David R Weir Tangchun Wu Wei Zheng Xiaofeng Zhu Michele K Evans Paul W Franks Vilmundur Gudnason Caroline Hayward Bernardo L Horta Tanika N Kelly Yongmei Liu Kari E North Alexandre C Pereira Paul M Ridker E Shyong Tai Rob M van Dam Ervin R Fox Sharon L R Kardia Ching-Ti Liu Dennis O Mook-Kanamori Michael A Province Susan Redline Cornelia M van Duijn Jerome I Rotter Charles B Kooperberg W James Gauderman Bruce M Psaty Kenneth Rice Patricia B Munroe Myriam Fornage L Adrienne Cupples Charles N Rotimi Alanna C Morrison Dabeeru C Rao Ruth J F Loos

Nat Commun 2019 01 22;10(1):376. Epub 2019 Jan 22.

Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, 10029, NY, USA.

Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. Read More

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http://dx.doi.org/10.1038/s41467-018-08008-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342931PMC
January 2019
27 Reads
10.742 Impact Factor

CBT for late-life insomnia and the accuracy of sleep and wake perceptions: Results from a randomized-controlled trial.

J Sleep Res 2019 Jan 4:e12809. Epub 2019 Jan 4.

David Geffen School of Medicine, University of California, Los Angeles, California, USA.

Subjective and objective estimates of sleep are often discordant among individuals with insomnia who typically under-report sleep time and over-report wake time at night. This study examined the impact and durability of cognitive-behavioural therapy for insomnia on improving the accuracy of sleep and wake perceptions in older adults, and tested whether changes in sleep quality were related to changes in the accuracy of sleep/wake perceptions. One-hundred and fifty-nine older veterans (97% male, mean age 72. Read More

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http://dx.doi.org/10.1111/jsr.12809DOI Listing
January 2019
3 Reads

[Chinese expert consensus on the assessment and management of stroke-related sleep disorders].

Authors:

Zhonghua Nei Ke Za Zhi 2019 Jan;58(1):17-26

Stroke-related sleep disorders (SSD) are common symptoms after stroke, which are common but easily ignored. Studies have shown that sleep disorders in stroke patients would have negative impact on prognosis. However, there is still a lack of consensus and guidance on SSD evaluation and management worldwide. Read More

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http://doi.med.wanfangdata.com.cn/10.3760/cma.j.issn.0578-14
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http://dx.doi.org/10.3760/cma.j.issn.0578-1426.2019.01.004DOI Listing
January 2019
3 Reads

Untangling PTSD and TBI: Challenges and Strategies in Clinical Care and Research.

Curr Neurol Neurosci Rep 2018 Nov 8;18(12):106. Epub 2018 Nov 8.

VISN 20 Northwest Network Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System, 1660 S. Columbian Way, S116 MIRECC, Seattle, WA, 98108, USA.

Purpose Of Review: Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) can result from similar injuries and can result in similar symptoms, such as problems with sleep, concentration, memory, and mood. Although PTSD and persistent sequelae due to a TBI (PST) have generally been viewed as pragmatically confounded but conceptually separable entities, we examine emerging evidence emphasizing the breadth of overlap in both clinical presentation and underlying pathophysiology between PST and PTSD.

Recent Findings: New evidence underscores the poor specificity of symptoms to etiology and emphasizes the potential, after both physical brain injury and traumatic stress, for changes in each of the three interacting systems that coordinate the body's response to the experience or expectation of major injury-the immune, endocrine, and neuromodulatory neurotransmitter systems. Read More

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http://link.springer.com/10.1007/s11910-018-0908-5
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http://dx.doi.org/10.1007/s11910-018-0908-5DOI Listing
November 2018
24 Reads

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.

Authors:
Symen Ligthart Ahmad Vaez Urmo Võsa Maria G Stathopoulou Paul S de Vries Bram P Prins Peter J Van der Most Toshiko Tanaka Elnaz Naderi Lynda M Rose Ying Wu Robert Karlsson Maja Barbalic Honghuang Lin René Pool Gu Zhu Aurélien Macé Carlo Sidore Stella Trompet Massimo Mangino Maria Sabater-Lleal John P Kemp Ali Abbasi Tim Kacprowski Niek Verweij Albert V Smith Tao Huang Carola Marzi Mary F Feitosa Kurt K Lohman Marcus E Kleber Yuri Milaneschi Christian Mueller Mahmudul Huq Efthymia Vlachopoulou Leo-Pekka Lyytikäinen Christopher Oldmeadow Joris Deelen Markus Perola Jing Hua Zhao Bjarke Feenstra Marzyeh Amini Jari Lahti Katharina E Schraut Myriam Fornage Bhoom Suktitipat Wei-Min Chen Xiaohui Li Teresa Nutile Giovanni Malerba Jian'an Luan Tom Bak Nicholas Schork Fabiola Del Greco M Elisabeth Thiering Anubha Mahajan Riccardo E Marioni Evelin Mihailov Joel Eriksson Ayse Bilge Ozel Weihua Zhang Maria Nethander Yu-Ching Cheng Stella Aslibekyan Wei Ang Ilaria Gandin Loïc Yengo Laura Portas Charles Kooperberg Edith Hofer Kumar B Rajan Claudia Schurmann Wouter den Hollander Tarunveer S Ahluwalia Jing Zhao Harmen H M Draisma Ian Ford Nicholas Timpson Alexander Teumer Hongyan Huang Simone Wahl YongMei Liu Jie Huang Hae-Won Uh Frank Geller Peter K Joshi Lisa R Yanek Elisabetta Trabetti Benjamin Lehne Diego Vozzi Marie Verbanck Ginevra Biino Yasaman Saba Ingrid Meulenbelt Jeff R O'Connell Markku Laakso Franco Giulianini Patrik K E Magnusson Christie M Ballantyne Jouke Jan Hottenga Grant W Montgomery Fernando Rivadineira Rico Rueedi Maristella Steri Karl-Heinz Herzig David J Stott Cristina Menni Mattias Frånberg Beate St Pourcain Stephan B Felix Tune H Pers Stephan J L Bakker Peter Kraft Annette Peters Dhananjay Vaidya Graciela Delgado Johannes H Smit Vera Großmann Juha Sinisalo Ilkka Seppälä Stephen R Williams Elizabeth G Holliday Matthijs Moed Claudia Langenberg Katri Räikkönen Jingzhong Ding Harry Campbell Michele M Sale Yii-Der I Chen Alan L James Daniela Ruggiero Nicole Soranzo Catharina A Hartman Erin N Smith Gerald S Berenson Christian Fuchsberger Dena Hernandez Carla M T Tiesler Vilmantas Giedraitis David Liewald Krista Fischer Dan Mellström Anders Larsson Yunmei Wang William R Scott Matthias Lorentzon John Beilby Kathleen A Ryan Craig E Pennell Dragana Vuckovic Beverly Balkau Maria Pina Concas Reinhold Schmidt Carlos F Mendes de Leon Erwin P Bottinger Margreet Kloppenburg Lavinia Paternoster Michael Boehnke A W Musk Gonneke Willemsen David M Evans Pamela A F Madden Mika Kähönen Zoltán Kutalik Magdalena Zoledziewska Ville Karhunen Stephen B Kritchevsky Naveed Sattar Genevieve Lachance Robert Clarke Tamara B Harris Olli T Raitakari John R Attia Diana van Heemst Eero Kajantie Rossella Sorice Giovanni Gambaro Robert A Scott Andrew A Hicks Luigi Ferrucci Marie Standl Cecilia M Lindgren John M Starr Magnus Karlsson Lars Lind Jun Z Li John C Chambers Trevor A Mori Eco J C N de Geus Andrew C Heath Nicholas G Martin Juha Auvinen Brendan M Buckley Anton J M de Craen Melanie Waldenberger Konstantin Strauch Thomas Meitinger Rodney J Scott Mark McEvoy Marian Beekman Cristina Bombieri Paul M Ridker Karen L Mohlke Nancy L Pedersen Alanna C Morrison Dorret I Boomsma John B Whitfield David P Strachan Albert Hofman Peter Vollenweider Francesco Cucca Marjo-Riitta Jarvelin J Wouter Jukema Tim D Spector Anders Hamsten Tanja Zeller André G Uitterlinden Matthias Nauck Vilmundur Gudnason Lu Qi Harald Grallert Ingrid B Borecki Jerome I Rotter Winfried März Philipp S Wild Marja-Liisa Lokki Michael Boyle Veikko Salomaa Mads Melbye Johan G Eriksson James F Wilson Brenda W J H Penninx Diane M Becker Bradford B Worrall Greg Gibson Ronald M Krauss Marina Ciullo Gianluigi Zaza Nicholas J Wareham Albertine J Oldehinkel Lyle J Palmer Sarah S Murray Peter P Pramstaller Stefania Bandinelli Joachim Heinrich Erik Ingelsson Ian J Deary Reedik Mägi Liesbeth Vandenput Pim van der Harst Karl C Desch Jaspal S Kooner Claes Ohlsson Caroline Hayward Terho Lehtimäki Alan R Shuldiner Donna K Arnett Lawrence J Beilin Antonietta Robino Philippe Froguel Mario Pirastu Tine Jess Wolfgang Koenig Ruth J F Loos Denis A Evans Helena Schmidt George Davey Smith P Eline Slagboom Gudny Eiriksdottir Andrew P Morris Bruce M Psaty Russell P Tracy Ilja M Nolte Eric Boerwinkle Sophie Visvikis-Siest Alex P Reiner Myron Gross Joshua C Bis Lude Franke Oscar H Franco Emelia J Benjamin Daniel I Chasman Josée Dupuis Harold Snieder Abbas Dehghan Behrooz Z Alizadeh

Am J Hum Genet 2018 Nov;103(5):691-706

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands. Electronic address:

C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is associated with multiple complex diseases. The genetic determinants of chronic inflammation remain largely unknown, and the causal role of CRP in several clinical outcomes is debated. We performed two genome-wide association studies (GWASs), on HapMap and 1000 Genomes imputed data, of circulating amounts of CRP by using data from 88 studies comprising 204,402 European individuals. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029297183032
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http://dx.doi.org/10.1016/j.ajhg.2018.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218410PMC
November 2018
35 Reads
10.931 Impact Factor

Managing challenging behaviours in dementia.

Singapore Med J 2018 Oct;59(10):514-518

Department of Psychological Medicine, Changi General Hospital, Singapore.

Dementia is a condition marked by the progressive and irreversible clinical syndrome of cognitive decline that is eventually severe enough to interfere with daily living. Management of dementia is often complex and requires a multidisciplinary approach. This article discusses the behavioural and psychological symptoms of dementia (BPSD), such as agitation, insomnia, restlessness, hallucinations, anxiety and depressed mood, for which patients and their caregivers commonly seek medical advice from their primary care clinician. Read More

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http://dx.doi.org/10.11622/smedj.2018125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199192PMC
October 2018
4 Reads

Sleep Architecture Changed Without RBD in Patients With FTDP-17.

J Clin Sleep Med 2018 Oct 15;14(10):1735-1739. Epub 2018 Oct 15.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Study Objectives: The aim of this study is to detect the features of sleep disorder via polysomnography (PSG) based on Chinese pedigree of frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17).

Methods: Five members (two symptomatic patients and three patients with a presymptomatic mutation) from the FTDP-17 pedigree were enrolled, in comparison with 9 patients with Parkinson disease (PD) and 11 control patients. Each patient underwent standard PSG and hypnogram analysis. Read More

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http://dx.doi.org/10.5664/jcsm.7384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175784PMC
October 2018
4 Reads

The efficacy of nasal airway stent (Nastent) on obstructive sleep apnoea and prediction of treatment outcomes.

J Oral Rehabil 2019 Jan 21;46(1):51-57. Epub 2018 Oct 21.

Department of Oral-Facial Disorders, Osaka University Graduate School of Dentistry, Suita-city, Osaka, Japan.

Background: Obstructive sleep apnoea (OSA) is characterised by recurrent episodes of partial or complete upper airway collapse during sleep and is highly prevalent in the general population. The nasopharyngeal airway stent (Nastent) is a specifically designed, preformed silicone tube that intends to maintain the upper airway patency during sleep and reduce snoring and sleep apnoea.

Objective(s): The purpose of this study was to determine the efficacy of Nastent treatment and examine predictors for Nastent treatment outcomes in patients with OSA. Read More

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http://dx.doi.org/10.1111/joor.12725DOI Listing
January 2019
14 Reads

Does the Geriatric Depression Scale measure depression in Parkinson's disease?

Int J Geriatr Psychiatry 2018 12 25;33(12):1662-1670. Epub 2018 Sep 25.

Research Service, Veterans Affairs San Diego Healthcare System, San Diego, California.

The Geriatric Depression Scale (GDS) is recommended for screening depression in individuals with Parkinson's disease (PD). Empirical evidence, however, is limited regarding its validity and factor structure in PD. Thus, the current study sought to evaluate the convergent and divergent validity of the GDS, as well as the structure and validity of the derived factors. Read More

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http://dx.doi.org/10.1002/gps.4970DOI Listing
December 2018
22 Reads

Effects of Pain and Sleep Quality on Falls Among Nursing Home Residents in Turkey.

Res Gerontol Nurs 2018 09;11(5):257-264

The current study was conducted to detect the incidence of falls among individuals in nursing homes, as well as the impact of pain and sleep quality on falls. The sample for this cross-sectional study comprised 291 older adults. Pain was assessed using the Geriatric Pain Measure and insomnia was assessed using the Insomnia Severity Index. Read More

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http://dx.doi.org/10.3928/19404921-20180810-01DOI Listing
September 2018
9 Reads

Therapeutic approaches for the management of sleep disorders in geriatric population.

Curr Med Chem 2018 Sep 3. Epub 2018 Sep 3.

Laboratorio de Neurociencias Moleculares e Integrativas. Escuela de Medicina División Ciencias de la Salud. Universidad Anáhuac Mayab Mérida, Yucatán. Mexico.

Objective: Aging is a natural biological phenomenon that occurs in human beings. With increasing of age, there is an appearance of deleterious changes related with progression onto pathological conditions, including hypertension, heart disease, diabetes, hearing and vision impairments, as well as sleep disorders. It is important to recognize that some sleep disturbances reported by aged subjects include insomnia, obstructive sleep apnea, restless legs syndrome, among others. Read More

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http://dx.doi.org/10.2174/0929867325666180904113115DOI Listing
September 2018
6 Reads

Effects of a 10-week functional training programme on pain, mood state, depression, and sleep in healthy older adults.

Psychogeriatrics 2018 Jul;18(4):292-298

Department of Corporal Expression, University of Jaen, Jaen, Spain.

Background: The purpose of this study was to analyze the effects of a 10-week functional training (FT) programme on pain, mood state, sleep, and depression in healthy older adults.

Method: A group of 38 older adults (32 women, 6 men) voluntarily participated in this study. Participants were randomly assigned to either the experimental group (n = 20; age: 75. Read More

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http://dx.doi.org/10.1111/psyg.12323DOI Listing
July 2018
5 Reads

Delirium associated with only one dose of zopiclone in an older adult.

Psychogeriatrics 2018 Jul;18(4):321-323

Unit for Aging Brain and Dementia, Department of Geriatric Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.

Both insomnia and its treatment can lead to the development of delirium in older adults. In the present case, delirium occurred after a single dose of zopiclone was given for insomnia treatment in an 84-year-old patient. Considering the case, patients and caregivers should be informed about the rare complication when zopiclone is prescribed. Read More

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http://dx.doi.org/10.1111/psyg.12320DOI Listing
July 2018
4 Reads

Buying time: a proof-of-concept randomized controlled trial to improve sleep quality and cognitive function among older adults with mild cognitive impairment.

Trials 2018 Aug 17;19(1):445. Epub 2018 Aug 17.

Department of Physical Therapy, Aging, Mobility and Cognitive Neuroscience Laboratory, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

Background: Current evidence suggests that good quality sleep is associated with preserved cognitive function and reduced dementia risk in older adults. Sleep complaints are especially common among older adults with mild cognitive impairment (MCI), and this may contribute to their increased risk for progression to dementia. Thus, improving their sleep may be important for maintaining their cognitive health. Read More

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http://dx.doi.org/10.1186/s13063-018-2837-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098594PMC
August 2018
13 Reads

Prevalence of restless legs syndrome in individuals with migraine: a systematic review and meta-analysis of observational studies.

Neurol Sci 2018 Nov 17;39(11):1927-1934. Epub 2018 Aug 17.

Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, People's Republic of China.

Objective: Recent studies have shown an association between migraine and restless legs syndrome (RLS), but RLS prevalence among individuals with migraine differs substantially across studies. The present work aimed to comprehensively assess available evidence to estimate RLS prevalence among individuals with migraine and non-migraine controls.

Method: Web of Science, PubMed, Embase, Chinese National Knowledge Infrastructure, Wanfang, and SinoMed databases were searched for observational and case-control studies of RLS prevalence among individuals with migraine. Read More

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http://dx.doi.org/10.1007/s10072-018-3527-7DOI Listing
November 2018
21 Reads

Sleep Disorders in Women Veterans.

Sleep Med Clin 2018 Sep 28;13(3):433-441. Epub 2018 Jun 28.

Division of Pulmonary Critical Care and Sleep Medicine, Department of Internal Medicine, Wayne State University, Harper University Hospital, 3 Hudson, 3990 John R, Detroit, MI 48323, USA.

Sleep disorders are common among women veterans and contribute to poor functioning and quality of life. Studies show that women veterans are particularly prone to insomnia, sleep-disordered breathing, and insufficient sleep. Standard cognitive behavioral therapy for insomnia (CBT-I) should be viewed as first-line therapy for insomnia disorder, and women veterans should be screened and treated for sleep-disordered breathing. Read More

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http://dx.doi.org/10.1016/j.jsmc.2018.04.010DOI Listing
September 2018
1 Read

Sleep quality as predictor of BMI in non-depressed caregivers of people with dementia.

Eat Weight Disord 2018 Oct 10;23(5):553-560. Epub 2018 Aug 10.

Department of Psychology, Sapienza University of Rome, Rome, Italy.

Purpose: Although most cross-sectional and longitudinal studies of children and adolescents have found a link between short duration of sleep and obesity, the literature related to adults provides a non-consensual framework. The aim of the present study was to examine the association between sleep quality and BMI in a population of caregivers looking after people suffering from dementia, with a view to identifying the moderating role of depressive symptoms in the relationship between sleep problems and BMI.

Methods: A total of 117 subjects took part in the study, filling in a Sociodemographic Questionnaire, the Pittsburgh Sleep Quality Index, the Eating behavior Questionnaire and The Center for Epidemiologic Studies-Depression. Read More

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http://dx.doi.org/10.1007/s40519-018-0560-8DOI Listing
October 2018
4 Reads

Use of Body Sensors to Examine Nocturnal Agitation, Sleep, and Urinary Incontinence in Individuals With Alzheimer's Disease.

J Gerontol Nurs 2018 Aug;44(8):19-26

Nighttime agitation, sleep disturbances, and urinary incontinence (UI) occur frequently in individuals with dementia and can add additional burden to family caregivers, although the co-occurrence of these symptoms is not well understood. The purpose of the current study was to determine the feasibility and acceptability of using passive body sensors in community-dwelling individuals with Alzheimer's disease (AD) by family caregivers and the correlates among these distressing symptoms. A single-group, descriptive design with convenience sampling of participants with AD and their family caregivers was undertaken to address the study aims. Read More

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http://dx.doi.org/10.3928/00989134-20180626-03DOI Listing
August 2018
29 Reads

Comprehensive analysis of the predictors of neurobehavioral symptom reporting in veterans.

Neurology 2018 Aug 27;91(8):e732-e745. Epub 2018 Jul 27.

From the Department of Veterans Affairs, Boston Healthcare System, Geriatric Research, Education, and Clinical Center and Translational Research Center for TBI and Stress Disorders, Boston, MA.

Objective: This study assessed the strength of military-related concussion-, psychological-, and behavioral-related measures to predict neurobehavioral symptom (NBS) reporting in order to help clarify the extent to which persistent NBS reflect lingering effects of concussion vs other psychological/behavioral factors among veterans.

Methods: Baseline analysis included 351 consecutively enrolled veterans in the Translational Research Center for Traumatic Brain Injury and Stress Disorders longitudinal cohort study. One hundred eighty-six returned for a follow-up evaluation averaging 24 months post baseline. Read More

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http://dx.doi.org/10.1212/WNL.0000000000006034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107265PMC
August 2018
6 Reads

Deterioration of executive dysfunction in elderly with REM sleep behavior disorder (RBD).

Neurobiol Aging 2018 Oct 30;70:242-246. Epub 2018 Jun 30.

Center of Neurology, Department of Neurodegeneration and Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany; German Center for Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany.

REM sleep behavior disorder (RBD) represents a major and relatively specific prodromal marker for synucleinopathies such as Parkinson's disease (PD), dementia with Lewy bodies, and multisystem atrophy. Because PD patients primarily suffer from executive dysfunction, we hypothesized that individuals with RBD show an impairment in the nonamnestic executive domain rather than in amnestic domains. To address this question, we investigated a cohort of 1145 healthy elderly (183 with RBD) cross-sectionally and a subgroup of 544 of them longitudinally (144 with RBD) over 6 years. Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.06.029DOI Listing
October 2018
24 Reads

Sleep debt at the community level: impact of age, sex, race/ethnicity and health.

Sleep Health 2018 08 29;4(4):317-324. Epub 2018 Jun 29.

Division of Geriatric Medicine and the Center for Sleep and Circadian Neurobiology, University of Pennsylvania Perelman School of Medicine.

Objectives: Insufficient sleep has become recognized as a pervasive problem in modern society. Sleep debt is a novel measure of sleep adequacy that may be useful in describing those at risk for inadequate sleep. Our objective was to investigate factors that may be associated with sleep debt at the population level, as well as build upon previous data that showed that minority groups may be more likely to have sleep debt. Read More

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http://dx.doi.org/10.1016/j.sleh.2018.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101976PMC
August 2018
5 Reads

When a patient with depression is feeling sleepy, be aware of sleep apnoea.

BMJ Case Rep 2018 Jul 10;2018. Epub 2018 Jul 10.

University Center for Psychiatry, University Medical Center Groningen, Groningen, The Netherlands.

A 67-year-old man was referred to an outpatient clinic of geriatric psychiatry because of persistent symptoms of depression and anxiety, accompanied by sleepiness. The latter had been evaluated multiple times in the general practice over several years; each time it was considered to be a symptom of depression. After referral, the patient was diagnosed with severe obstructive sleep apnoea (OSA), comorbid to a depressive and anxiety disorder. Read More

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http://dx.doi.org/10.1136/bcr-2018-224873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058169PMC
July 2018
16 Reads

Use of Actigraphy for the Evaluation of Sleep Disorders and Circadian Rhythm Sleep-Wake Disorders: An American Academy of Sleep Medicine Systematic Review, Meta-Analysis, and GRADE Assessment.

J Clin Sleep Med 2018 Jul 15;14(7):1209-1230. Epub 2018 Jul 15.

Saint Thomas Medical Partners-Sleep Specialists, Nashville, Tennessee.

Introduction: The purpose of this systematic review is to provide supporting evidence for a clinical practice guideline on the use of actigraphy.

Methods: The American Academy of Sleep Medicine commissioned a task force of experts in sleep medicine. A systematic review was conducted to identify studies that compared the use of actigraphy, sleep logs, and/or polysomnography. Read More

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http://dx.doi.org/10.5664/jcsm.7228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040804PMC
July 2018
10 Reads

Use of Actigraphy for the Evaluation of Sleep Disorders and Circadian Rhythm Sleep-Wake Disorders: An American Academy of Sleep Medicine Clinical Practice Guideline.

J Clin Sleep Med 2018 Jul 15;14(7):1231-1237. Epub 2018 Jul 15.

Saint Thomas Medical Partners-Sleep Specialists, Nashville, Tennessee.

Introduction: The purpose of this guideline is to establish clinical practice recommendations for the use of actigraphy in adult and pediatric patients with suspected or diagnosed sleep disorders or circadian rhythm sleep-wake disorders.

Methods: The American Academy of Sleep Medicine (AASM) commissioned a task force of experts in sleep medicine to develop recommendations and assigned strengths based on a systematic review of the literature and an assessment of the evidence using the GRADE process. The task force provided a summary of the relevant literature and the quality of evidence, the balance of benefits and harms, patient values and preferences, and resource use considerations that support the recommendations. Read More

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http://dx.doi.org/10.5664/jcsm.7230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040807PMC
July 2018
19 Reads

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

Authors:
Mary F Feitosa Aldi T Kraja Daniel I Chasman Yun J Sung Thomas W Winkler Ioanna Ntalla Xiuqing Guo Nora Franceschini Ching-Yu Cheng Xueling Sim Dina Vojinovic Jonathan Marten Solomon K Musani Changwei Li Amy R Bentley Michael R Brown Karen Schwander Melissa A Richard Raymond Noordam Hugues Aschard Traci M Bartz Lawrence F Bielak Rajkumar Dorajoo Virginia Fisher Fernando P Hartwig Andrea R V R Horimoto Kurt K Lohman Alisa K Manning Tuomo Rankinen Albert V Smith Salman M Tajuddin Mary K Wojczynski Maris Alver Mathilde Boissel Qiuyin Cai Archie Campbell Jin Fang Chai Xu Chen Jasmin Divers Chuan Gao Anuj Goel Yanick Hagemeijer Sarah E Harris Meian He Fang-Chi Hsu Anne U Jackson Mika Kähönen Anuradhani Kasturiratne Pirjo Komulainen Brigitte Kühnel Federica Laguzzi Jian'an Luan Nana Matoba Ilja M Nolte Sandosh Padmanabhan Muhammad Riaz Rico Rueedi Antonietta Robino M Abdullah Said Robert A Scott Tamar Sofer Alena Stančáková Fumihiko Takeuchi Bamidele O Tayo Peter J van der Most Tibor V Varga Veronique Vitart Yajuan Wang Erin B Ware Helen R Warren Stefan Weiss Wanqing Wen Lisa R Yanek Weihua Zhang Jing Hua Zhao Saima Afaq Najaf Amin Marzyeh Amini Dan E Arking Tin Aung Eric Boerwinkle Ingrid Borecki Ulrich Broeckel Morris Brown Marco Brumat Gregory L Burke Mickaël Canouil Aravinda Chakravarti Sabanayagam Charumathi Yii-Der Ida Chen John M Connell Adolfo Correa Lisa de Las Fuentes Renée de Mutsert H Janaka de Silva Xuan Deng Jingzhong Ding Qing Duan Charles B Eaton Georg Ehret Ruben N Eppinga Evangelos Evangelou Jessica D Faul Stephan B Felix Nita G Forouhi Terrence Forrester Oscar H Franco Yechiel Friedlander Ilaria Gandin He Gao Mohsen Ghanbari Bruna Gigante C Charles Gu Dongfeng Gu Saskia P Hagenaars Göran Hallmans Tamara B Harris Jiang He Sami Heikkinen Chew-Kiat Heng Makoto Hirata Barbara V Howard M Arfan Ikram Ulrich John Tomohiro Katsuya Chiea Chuen Khor Tuomas O Kilpeläinen Woon-Puay Koh José E Krieger Stephen B Kritchevsky Michiaki Kubo Johanna Kuusisto Timo A Lakka Carl D Langefeld Claudia Langenberg Lenore J Launer Benjamin Lehne Cora E Lewis Yize Li Shiow Lin Jianjun Liu Jingmin Liu Marie Loh Tin Louie Reedik Mägi Colin A McKenzie Thomas Meitinger Andres Metspalu Yuri Milaneschi Lili Milani Karen L Mohlke Yukihide Momozawa Mike A Nalls Christopher P Nelson Nona Sotoodehnia Jill M Norris Jeff R O'Connell Nicholette D Palmer Thomas Perls Nancy L Pedersen Annette Peters Patricia A Peyser Neil Poulter Leslie J Raffel Olli T Raitakari Kathryn Roll Lynda M Rose Frits R Rosendaal Jerome I Rotter Carsten O Schmidt Pamela J Schreiner Nicole Schupf William R Scott Peter S Sever Yuan Shi Stephen Sidney Mario Sims Colleen M Sitlani Jennifer A Smith Harold Snieder John M Starr Konstantin Strauch Heather M Stringham Nicholas Y Q Tan Hua Tang Kent D Taylor Yik Ying Teo Yih Chung Tham Stephen T Turner André G Uitterlinden Peter Vollenweider Melanie Waldenberger Lihua Wang Ya Xing Wang Wen Bin Wei Christine Williams Jie Yao Caizheng Yu Jian-Min Yuan Wei Zhao Alan B Zonderman Diane M Becker Michael Boehnke Donald W Bowden John C Chambers Ian J Deary Tõnu Esko Martin Farrall Paul W Franks Barry I Freedman Philippe Froguel Paolo Gasparini Christian Gieger Jost Bruno Jonas Yoichiro Kamatani Norihiro Kato Jaspal S Kooner Zoltán Kutalik Markku Laakso Cathy C Laurie Karin Leander Terho Lehtimäki Lifelines Cohort Study Patrik K E Magnusson Albertine J Oldehinkel Brenda W J H Penninx Ozren Polasek David J Porteous Rainer Rauramaa Nilesh J Samani James Scott Xiao-Ou Shu Pim van der Harst Lynne E Wagenknecht Nicholas J Wareham Hugh Watkins David R Weir Ananda R Wickremasinghe Tangchun Wu Wei Zheng Claude Bouchard Kaare Christensen Michele K Evans Vilmundur Gudnason Bernardo L Horta Sharon L R Kardia Yongmei Liu Alexandre C Pereira Bruce M Psaty Paul M Ridker Rob M van Dam W James Gauderman Xiaofeng Zhu Dennis O Mook-Kanamori Myriam Fornage Charles N Rotimi L Adrienne Cupples Tanika N Kelly Ervin R Fox Caroline Hayward Cornelia M van Duijn E Shyong Tai Tien Yin Wong Charles Kooperberg Walter Palmas Kenneth Rice Alanna C Morrison Paul Elliott Mark J Caulfield Patricia B Munroe Dabeeru C Rao Michael A Province Daniel Levy

PLoS One 2018 18;13(6):e0198166. Epub 2018 Jun 18.

The Framingham Heart Study, Framingham, Massachusetts, United States of America.

Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association study accounting for gene-alcohol consumption interaction for BP might identify additional BP loci and contribute to the understanding of alcohol-related BP regulation. We conducted a large two-stage investigation incorporating joint testing of main genetic effects and single nucleotide variant (SNV)-alcohol consumption interactions. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198166PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005576PMC
January 2019
99 Reads
3.234 Impact Factor

The influence of personality traits on perception of pain in older adults - Findings from the Swedish National Study on Aging and Care - Blekinge study.

Scand J Pain 2015 Apr 1;7(1):3-8. Epub 2015 Apr 1.

Department of Health, Blekinge Institute of Technology, Karlskrona, Sweden.

Background and aims The experience of pain may vary in accordance with personality traits and individual characteristics. Neuroticism is demonstrated to constitute a vulnerability factor among younger and middle-aged pain patients. The combination of openness and neuroticism is associated with high anxiety/depression scores among adult individuals with chronic conditions. Read More

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http://dx.doi.org/10.1016/j.sjpain.2014.12.002DOI Listing
April 2015
5 Reads

Evidence for altered brain reactivity to norepinephrine in Veterans with a history of traumatic stress.

Neurobiol Stress 2018 Feb 15;8:103-111. Epub 2018 Mar 15.

VISN 20 Northwest Network Mental Illness Research, Education, and Clinical Center (MIRECC), VA Puget Sound Health Care System, 1660 S. Columbian Way, S116 MIRECC, Seattle, WA 98108, USA.

Background: Increases in the quantity or impact of noradrenergic signaling have been implicated in the pathophysiology of posttraumatic stress disorder (PTSD). This increased signaling may result from increased norepinephrine (NE) release, from altered brain responses to NE, or from a combination of both factors. Here, we tested the hypothesis that Veterans reporting a history of trauma exposure would show an increased association between brain NE and mental health symptoms commonly observed after trauma, as compared to Veterans who did not report a history of trauma exposure, consistent with the possibility of increased brain reactivity to NE after traumatic stress. Read More

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http://dx.doi.org/10.1016/j.ynstr.2018.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991318PMC
February 2018
28 Reads

Daytime bright light exposure, metabolism, and individual differences in wake and sleep energy expenditure during circadian entrainment and misalignment.

Neurobiol Sleep Circadian Rhythms 2018 Jan 29;4:49-56. Epub 2017 Dec 29.

Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, USA.

Daytime light exposure has been reported to impact or have no influence on energy metabolism in humans. Further, whether inter-individual differences in wake, sleep, 24 h energy expenditure, and RQ during circadian entrainment and circadian misalignment are stable across repeated 24 h assessments is largely unknown. We present data from two studies: Study 1 of 15 participants (7 females) exposed to three light exposure conditions: continuous typical room ~100 lx warm white light, continuous ~750 lx warm white light, and alternating hourly ~750 lx warm white and blue-enriched white light on three separate days in a randomized order; and Study 2 of 14 participants (8 females) during circadian misalignment induced by a simulated night shift protocol. Read More

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http://dx.doi.org/10.1016/j.nbscr.2017.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986103PMC
January 2018
11 Reads

The role of mirtazapine in patients with fibromyalgia: a systematic review.

Rheumatol Int 2018 Dec 2;38(12):2217-2224. Epub 2018 Jun 2.

Pharmacy Department (119), Durham VA Medical Center, 508 Fulton St., Durham, NC, 27705, USA.

Mirtazapine is commonly used to treat major depressive disorder. Due to its effects on multiple neurotransmitters, it has been investigated for possible benefits in patients with fibromyalgia. The objective of this systematic review is to assess the efficacy and safety of mirtazapine in the treatment of patients with fibromyalgia. Read More

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http://dx.doi.org/10.1007/s00296-018-4068-3DOI Listing
December 2018
5 Reads

Cognitive Impairment and Mortality in a Population-Based Parkinson's Disease Cohort.

J Parkinsons Dis 2018 ;8(2):353-362

Department of Neurology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.

Background: Parkinson's disease (PD) is a heterogeneous disorder with variability in phenotype and progression.

Objective: We describe characteristics of PD patients in the largest population-based cohort followed for progression to date, and evaluate clinical risk factors for cognitive impairment and mortality.

Methods: We collected longitudinal data using the Unified Parkinson's Disease Rating Scale (UPDRS), Mini-Mental State Exam (MMSE), and Geriatric Depression Scale (GDS) in 242 new-onset PD patients followed for progression. Read More

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http://dx.doi.org/10.3233/JPD-171257DOI Listing
January 2018
6 Reads

Mistimed food intake and sleep alters 24-hour time-of-day patterns of the human plasma proteome.

Proc Natl Acad Sci U S A 2018 06 21;115(23):E5390-E5399. Epub 2018 May 21.

Sleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, CO 80309;

Proteomics holds great promise for understanding human physiology, developing health biomarkers, and precision medicine. However, how much the plasma proteome varies with time of day and is regulated by the master circadian suprachiasmatic nucleus brain clock, assessed here by the melatonin rhythm, is largely unknown. Here, we assessed 24-h time-of-day patterns of human plasma proteins in six healthy men during daytime food intake and nighttime sleep in phase with the endogenous circadian clock (i. Read More

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http://dx.doi.org/10.1073/pnas.1714813115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003375PMC
June 2018
2 Reads

Sleep Apnea and Sleep-Disordered Breathing.

Otolaryngol Clin North Am 2018 Aug 17;51(4):827-833. Epub 2018 May 17.

Department of Otolaryngology-Head and Neck Surgery, Weill Cornell Medicine, New York Presbyterian Hospital, 1305 York Avenue, New York, NY 10021, USA. Electronic address:

Older adults undergo gradual changes in their sleep patterns. It is important to differentiate normal age-related sleep changes from sleep disorders. Because sleep disorders can impact an older adult's day-to-day life and contribute to various comorbidities, these patients should be carefully screened by using a detailed medical history, combined with a detailed sleep history. Read More

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http://dx.doi.org/10.1016/j.otc.2018.03.009DOI Listing
August 2018
14 Reads

Technologies for participatory medicine and health promotion in the elderly population.

Medicine (Baltimore) 2018 May;97(20):e10791

Faculty of Health Science.

Introduction: The progressive aging of the population is a socio-demographic phenomenon experienced by most countries in the world in recent decades, especially in Japan and in many European Union countries. During this process, so-called "geriatric syndromes" frequently occur. The focus of this study is the quality of life of the elderly in relation to these 3 factors: risk of falls, urinary incontinence, and insomnia. Read More

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http://dx.doi.org/10.1097/MD.0000000000010791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976343PMC
May 2018
5 Reads