Search Our Scientific Publications & Authors

Int J Urol 2018 Dec 17. Epub 2018 Dec 17.

Kyorin Pharmaceutical, Tokyo, Japan.

Objectives: To investigate the efficacy of vibegron on nocturia in patients with overactive bladder.

Methods: Among the Japanese overactive bladder patients enrolled in the placebo-controlled, multicenter, randomized, double-blind phase 3 study of vibegron, a total of 669 patients with nocturia (≥1 nocturnal void) were included. Changes from baseline in micturition parameters were compared for vibegron treatment (50 and 100 mg/day) versus placebo. Read More

Fortschr Neurol Psychiatr 2018 Dec 17. Epub 2018 Dec 17.

Zentralinstitut für Seelische Gesundheit, AG Schizophrenieforschung; Medizinische Fakultät Mannheim / Universität Heidelberg.

The concept of mental disorder has many facets. Specific concepts of disease or disorder stand for individual entities, classified as diagnoses. Ideally, they are based on discrete physical, neurobiological or - as is the case with hereditary diseases - genetic findings. Read More

Am J Nephrol 2018 Dec 17;49(1):41-51. Epub 2018 Dec 17.

Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei,

Background: Extensive studies have demonstrated that sleep is an important modulator of cardiovascular and metabolic diseases. However, its impact on renal function remains uncertain.

Methods: A total of 26,249 adults aged ≥20 years were recruited through voluntary health examinations in Taiwan. Read More

Sleep Med 2018 Nov 19;54:142-152. Epub 2018 Nov 19.

Division of Clinical Psychology and Psychotherapy, Department of Psychology, Saarland University, Campus A1 3, D-66123 Saarbrücken, Germany.

Background: Extensive empirical evidence indicates that sleep plays an active role in memory consolidation. Moreover, sleep has been found to preferentially enhance emotional memories and may modulate affective reactions to previously encountered stimuli. Notably, recent findings suggest that disruptions of sleep-related memory processing could be involved in posttraumatic symptom development such that sleep disturbances may accelerate symptoms of intrusive re-experiencing. Read More

Curr Opin Psychiatry 2018 Dec 14. Epub 2018 Dec 14.

Department of Molecular and Human Genetics, Baylor College of Medicine.

Purpose Of Review: To provide an update of the most recent studies on Smith-Magenis syndrome (SMS) with a focus on the unique pattern of behavioral and sleep disturbances associated with the condition.

Recent Findings: The recent literature on SMS has focused on the characteristic severe behavioral and sleep disturbances. A better understanding of the underlying pathophysiological mechanisms and common clinical course has helped further characterize SMS, while much is left to be discovered in regard to effective treatment/management. Read More

Crit Care Med 2019 Jan;47(1):133-135

Center for Healthcare Delivery Science; and Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA The Pulmonary Center, and Evans Center for Implementation and Improvement Sciences, Department of Medicine, Boston University School of Medicine; and Department of Health Law, Policy and Management, Boston University School of Public Health, Boston, MA.

Crit Care Med 2019 Jan;47(1):1-2

Department of Critical Care Medicine, Queen's University and Kingston Health Sciences Center, Kingston, ON, Canada Icahn School of Medicine at Mount Sinai, New York, NY.

Chronobiol Int 2018 Dec 17:1-11. Epub 2018 Dec 17.

b Division of Cancer Epidemiology and Genetics , National Cancer Institute , Rockville , MD , USA.

The circadian system influences virtually all biological functions. Understanding the impact of circadian variation on metabolism may provide insight into mechanisms of circadian-associated disorders and guide the implementation of chrono-therapy. Previous research has reported circadian variation in 7-20% of metabolites in human blood. Read More

Behav Sleep Med 2018 Dec 17:1-9. Epub 2018 Dec 17.

a Department of Psychology , State University of New York Binghamton , Binghamton , NY.

Objective/background: Numerous psychiatric conditions characterized by repetitive negative thinking (RNT) are also frequently associated with disruptions in the duration and timing of sleep. The emerging literature supports that these types of sleep disruptions may be associated with negative psychological consequences such as depressed mood, anxiety, and poor emotion regulation, all of which have features of RNT. There is a paucity of research on the association between RNT and disruptions in sleep duration and timing in adolescents. Read More

Exp Clin Psychopharmacol 2018 Dec 17. Epub 2018 Dec 17.

West Virginia University School of Medicine.

It is well-documented in the literature that individuals repeatedly exposed to cocaine exhibit cognitive impairment and that cognitive dysfunction is a risk factor for poor treatment outcomes in those with cocaine use disorder (CUD). Specific deficits related to attention, episodic memory, working memory, and executive functioning are the most common deficits noted in this population. Given that cognitive impairment is a risk factor for poor treatment outcomes in those with CUD, identifying possible moderating factors contributing to and/or exacerbating cocaine-related cognitive deficits is of great importance. Read More

FP Essent 2018 Dec;475:11-17

University of Michigan Medical School Department of Pediatrics - Developmental Behavioral Pediatrics, 1522 Simpson Road, East Ann Arbor, MI 48109-5718.

Attention-deficit/hyperactivity disorder (ADHD) is a neurobehavioral condition that affects more than 9% of US children and adolescents and often is seen in family medicine settings. A comprehensive evaluation for ADHD gathers information across time and settings; considers common comorbid or alternative conditions, such as learning disabilities and disorders of mood or anxiety, vision, hearing, and sleep; and includes a thorough physical examination. The need for additional evaluation is determined by the history and physical examination results. Read More

Pediatr Endocrinol Rev 2018 Dec;16(2):266-274

Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil, E-mail:

Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness, cataplexy, sleep paralysis and hypnagogic and hypnopompic hallucinations. The onset of the symptoms usually occurs in childhood, and previous studies have reported an association between narcolepsy and other endocrine diseases in the pediatric population, such as obesity and precocious puberty. The incidence of overweight or obesity ranges from 25% to 74% in patients with narcolepsy type I, while precocious puberty is present in 17% of children with narcolepsy with cataplexy. Read More

Respirology 2018 Dec 17. Epub 2018 Dec 17.

Institute for Pulmonary Rehabilitation Research, Schoen Klinik Berchtesgadener Land, Schoenau am Koenigssee, Germany.

Demand oxygen delivery systems (DODS) enable prolongation of liquid oxygen cylinder life compared to continuous oxygen flow (CONT) use. Evidence is lacking, however, regarding their efficacy. This study investigated the literature comparing liquid-based CONT to DODS in patients with chronic obstructive pulmonary disease (COPD). Read More

Pediatr Dermatol 2018 Dec 16. Epub 2018 Dec 16.

Department of Dermatology, University of California San Francisco, San Francisco, California.

Background: Atopic dermatitis (AD) is an extremely common childhood disease, with considerable impact on the quality of life of affected children and their families. While pruritus is the hallmark symptom of this disease, AD has been well-documented to impact patients beyond physical symptoms, resulting in behavior problems, mood disorders, and sleep disturbance.

Objective: This literature review outlines how atopic dermatitis impacts the quality of life of families of children affected by AD. Read More

Physiol Rep 2018 Dec;6(24):e13942

Department of Human Science, Faculty of Design, Kyushu University, Fukuoka, Japan.

Light-induced melatonin suppression in children is reported to be more sensitive to white light at night than that in adults; however, it is unclear whether it depends on spectral distribution of lighting. In this study, we investigated the effects of different color temperatures of LED lighting on children's melatonin secretion during the night. Twenty-two healthy children (8. Read More

Mol Genet Genomic Med 2018 Dec 16. Epub 2018 Dec 16.

Department of Respiratory and Sleep Medicine in the First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.

Background: Lung adenocarcinoma (LUAD) accounts for approximately 40% of all lung cancer patients. There is an urgent need to understand the mechanisms of cancer progression in LUAD and to identify useful biomarkers to predict prognosis.

Methods: In this study, Oncomine database was used to identify potential genes contributed to cancer progression. Read More

ACS Omega 2018 Nov 26;3(11):15916-15923. Epub 2018 Nov 26.

Laboratório de Biologia Teórica e Computacional, Departamento de Biologia Celular, Universidade de Brasília, DF, 70910-900 Brasília, Brazil.

2,2,2-Trichloroethanol (TCE) is the active form of the sedative hypnotic drug chloral hydrate, one of the oldest sleep medications in the market. Understanding of TCE's action mechanisms to its many targets, particularly within the ion channel family, could benefit from the state-of-the-art computational molecular studies. In this direction, we employed de novo modeling aided by the force field toolkit to develop CHARMM36-compatible TCE parameters. Read More

Respir Med Case Rep 2019 26;26:68-72. Epub 2018 Nov 26.

Haut-Leveque Cardiology Hospital, Pessac, France.

Purpose: The SERVE-HF study reported a risk of cardiovascular death associated with adaptive servo-ventilation (ASV) for central sleep apnea in patients with chronic heart failure with reduced left ventricular ejection fraction (LVEF). Therefore, we adopted in May 2015 a safety procedure in our 32 patients with ASV since 2006. It led to ASV removal in four patients due to ≤45% LVEF. Read More

Pilot Feasibility Stud 2018 10;4:183. Epub 2018 Dec 10.

1National Institutes of Health Clinical Center, Bethesda, USA.

Abstract: Alcohol use disorder (AUD) is characterized by problematic drinking that becomes severe. Individuals with AUD often experience insomnia and other sleep disturbances at various phases of recovery. Cognitive behavioral therapy for insomnia (CBT-I) is an efficacious non-pharmacological treatment for insomnia and is recommended as a first-line treatment for adults with chronic insomnia. Read More

Eur J Psychol 2018 Nov 30;14(4):880-896. Epub 2018 Nov 30.

Department of Health, Exercise Science and Recreation Management, Physical Activity Epidemiology Laboratory, Exercise Psychology Laboratory, The University of Mississippi, Oxford, MS, USA.

To examine the prospective association of personality with individual behavior, multibehavior and clustered health behavior profiles. A prospective study design was employed. Two hundred young adults provided baseline data and 126 (mean age: 21. Read More

Front Endocrinol (Lausanne) 2018 29;9:714. Epub 2018 Nov 29.

Second Internal Medicine Department, Vinohrady Teaching Hospital, Prague, Czechia.

Obstructive sleep apnea (OSA) is a common disorder in Type 2 diabetes (T2D) patients further increasing their already high cardiovascular risk. As T2D patients typically not report OSA symptoms, systematic screening for OSA in this population is warranted. We aimed to determine the readiness of T2D patients to undergo screening and to compare their adherence to continuous positive airway pressure (CPAP) therapy with "regular" sleep clinic patients who typically seek medical advice on their own initiative. Read More

Front Neurol 2018 29;9:1022. Epub 2018 Nov 29.

Monash Institute of Cognitive and Clinical Neurosciences and School of Psychological Sciences, Monash University, Melbourne, VIC, Australia.

Circadian disruption is associated with poor health outcomes, including sleep and mood disorders. The suprachiasmatic nucleus (SCN) of the anterior hypothalamus acts as the master biological clock in mammals, regulating circadian rhythms throughout the body. The clock is synchronized to the day/night cycle via retinal light exposure. Read More

Front Psychol 2018 29;9:2413. Epub 2018 Nov 29.

Norwegian Competence Center for Sleep Disorders, Haukeland University Hospital, Bergen, Norway.

To compare the effects of a self-help book for insomnia to that of sleep hygiene advice in a randomized controlled trial with follow-up after about 3 months among patients who were diagnosed with obstructive sleep apnea (OSA) and comorbid chronic insomnia, and who were concurrently initiating treatment with continuous positive airway pressure (CPAP). In all, 164 patients were included. OSA was diagnosed and categorized based on a standard respiratory polygraphic sleep study using a type 3 portable monitor. Read More

Front Neurosci 2018 30;12:892. Epub 2018 Nov 30.

International Institute for Integrative Sleep Medicine, University of Tsukuba, Tsukuba, Japan.

Neurons expressing neuropeptide orexins (hypocretins) in the lateral hypothalamus (LH) and serotonergic neurons in the dorsal raphe nucleus (DR) both play important roles in the regulation of sleep/wakefulness states, and show similar firing patterns across sleep/wakefulness states. Orexin neurons send excitatory projections to serotonergic neurons in the DR, which express both subtypes of orexin receptors (Mieda et al., 2011), while serotonin (5-HT) potently inhibits orexin neurons through activation of 5HT receptors (5HT1ARs). Read More

Clin Ophthalmol 2018 29;12:2471-2481. Epub 2018 Nov 29.

Public Health Sciences, Environmental Health Division, University of Miami, Miami, FL, USA,

Purpose: To compare dry eye (DE) diagnosis patterns by season in Miami vis-a-vis the US and examine differences in DE symptoms and signs by season in Miami.

Patients And Methods: US veteran affairs (VA) patient visits with ICD-9 codes for DE (375.15) and routine medical examination (V70. Read More

Sleep Med 2018 Nov 14. Epub 2018 Nov 14.

Department of Sleep Medicine, Sahlgrenska University Hospital, Sweden; Sahlgrenska Academy, Gothenburg University, Sweden. Electronic address:

Objective/background: The Clinical Global Impression scale (CGI) reflects the clinician's assessment of the disease impact on patient's global functioning. We assessed predictors of CGI scale rating in patients with obstructive sleep apnea (OSA).

Patients/methods: Consecutive patients with suspected OSA (n = 7581) were identified in the European Sleep Apnea Database (ESADA). Read More

Sleep Med 2018 Nov 26. Epub 2018 Nov 26.

University of Alberta, Edmonton, AB, Canada.

Objectives/background: This paper outlines the current state of Canadian training, clinical services, research, and advocacy initiatives related to non-respiratory sleep disorders, with a specific focus on insomnia, the most common sleep problem in children.

Methods: Information for this narrative review was collected from peer-reviewed publications, web-resources, and personal communications and experiences.

Results: It is estimated that approximately one-third of Canadian children and youth present with insomnia, and that this is impacting their physical and mental health, as well as learning in school. Read More

Sleep Med 2018 Oct 10. Epub 2018 Oct 10.

Sleep Research Institute, Paseo de la Habana 151, 28036, Madrid, Spain. Electronic address:

J Stroke Cerebrovasc Dis 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurology, KMC Manipal, Karnataka, India.

Background: Sleep apnea is increasingly being recognized as 1 of the important, modifiable risk factors of stroke and cardiovascular diseases. Sleep apnea is thought to impair the functional recovery following stroke. Hence, we evaluated the patients with acute ischemic stroke for prevalence of sleep apnea and compared the functional outcomes of patients with and without sleep apnea, at 3rd month of acute ischemic stroke. Read More

Int J Pediatr Otorhinolaryngol 2019 Jan 12;116:38-42. Epub 2018 Oct 12.

Department of Otorhinolaryngology, The Second Affiliated Hospital of Xi'an Jiaotong University, No.157, Xiwu Road, Xi'an, 710004, Shaanxi, China. Electronic address:

Objectives: Different experiment approaches have demonstrated that children with obstructive sleep apnea (OSA) exhibit neurocognitive and behavioral deficits. This review summarized the potential biomarkers of OSA-associated neurocognitive impairment in children.

Methods: A scoping review of studies on children with OSA that evaluated the potential value of different markers in identifying neurocognitive impairment was undertaken. Read More

Int J Pediatr Otorhinolaryngol 2019 Jan 3;116:177-180. Epub 2018 Nov 3.

University of Auckland, Department of Surgery, PO Box 99743, Newmarket, Auckland, 1149, New Zealand.

Introduction: Children who undergo adenotonsillectomy have a range of symptoms. Some present with infective symptoms, others with obstructive symptoms, and many with a combination of both. The most common surgical indication has changed over the past several decades from infective symptoms to obstructive symptoms. Read More

Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota.

Periodic limb movements in sleep (PLMS) are associated with adverse outcomes in patients with heart failure (HF). The aim of this study was to investigate whether PLMS change in response to adaptive servo-ventilation (ASV) for central sleep apnea (CSA) in patients with HF. We examined polysomnographic studies conducted between 2010 and 2014 at Mayo Clinic, Rochester, Minnesota (n = 14,444). Read More

Psychiatr Serv 2018 Dec 17:appips201800321. Epub 2018 Dec 17.

Department of Psychiatry, University of Michigan, Ann Arbor, and Center for Clinical Management Research, Department of Veterans Affairs Ann Arbor Healthcare System, Ann Arbor.

Objective:: Goals were to determine the prevalence of benzodiazepine use (as prescribed and misuse), characterize misuse, and examine variation by age.

Methods:: A cross-sectional analysis was conducted of 2015 and 2016 National Survey on Drug Use and Health data limited to adults ≥18 (N=86,186) and data from those respondents reporting benzodiazepine use (N=10,290). Measurements included past-year prescription benzodiazepine use and misuse ("any way a doctor did not direct"), substance use disorders, mental illness, and demographic characteristics. Read More

J Biol Rhythms 2018 Dec 17:748730418818655. Epub 2018 Dec 17.

Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA.

Age-related disrupted sleep has been associated with modifications in the timing of endogenous circadian rhythms. There are studies suggesting a decreased sensitivity of the aging circadian pacemaker to light. In this study, we aimed to test whether a moderate illuminance light stimulus would produce significant phase shifts in older adults, and whether those would fall in a range consistent with the illuminance response curve (IRC) we previously reported in older adults. Read More

J Oral Rehabil 2018 Dec 16. Epub 2018 Dec 16.

Southern Medical University, Savaid Medical School, University of the Chinese Academy of Sciences.

Background: Erosive tooth wear (ETW) has become a crucial oral health problem over the decades in China.

Objectives: To explore the prevalence and risk indicators of ETW among adolescents in Guangzhou, south China.

Methods: A cross-sectional survey of 720 participants was conducted in Guangzhou, using an equal-sized, stratified, multistage random sampling approach. Read More

Sleep Breath 2018 Dec 15. Epub 2018 Dec 15.

Children's Hospital Los Angeles, 4650 Sunset Blvd., #83, Los Angeles, CA, USA.

Purpose: Overweight and obese children have demonstrated reduced rapid eye movement (REM) sleep, affecting energy balance regulation and predisposition to weight gain. Obstructive sleep apnea (OSA) is a known cause of decreased REM sleep. The purpose of this study is to examine the association between the percentage of REM sleep, BMI z-score, and OSA severity in overweight and obese adolescents. Read More

Support Care Cancer 2018 Dec 15. Epub 2018 Dec 15.

Department of Medicine, Division of Hematology/Oncology, Vanderbilt University Medical Center, 2220 Pierce Avenue, 777 Preston Research Building, Nashville, TN, 37232, USA.

Purpose: Neuroinflammation and central sensitization from cancer and its therapy may result in chronic systemic symptoms (CSS) such as fatigue, sleep disturbance, chronic widespread pain, mood disorders, neuropsychiatric symptoms, and temperature dysregulation. We undertook a cross-sectional study of CSS in head and neck cancer (HNC) survivors to determine their frequency, severity, and impact.

Methods: HNC patients without evidence of recurrence who were at least 12 months post-treatment completed a one-time battery of self-report measures including the Vanderbilt Head and Neck Symptom survey plus the General Symptom Subscale, the Body Image Quality of Life Inventory, Neurotoxicity Rating Scale, the Profile of Mood States, and a five-item quality of life measure. Read More

Inj Prev 2018 Dec 15. Epub 2018 Dec 15.

Faculty of Health Sciences, Western University, London, Ontario, Canada.

Background: The majority of shift workers experience insufficient sleep as a result of their employment. Insufficient sleep is associated with impaired neurocognitive functioning, affecting key skills required for driving, resulting in shift workers experiencing a disproportionate burden of RTC injuries and fatalities. Yet, to our knowledge, no systematic literature review (SLR) exists to critically appraise and synthesise evidence on the determinants of fitness to drive (assessed on-road) and driving performance (assessed in a driving simulator) in shift workers with insufficient sleep. Read More

Thorax 2018 Dec 15. Epub 2018 Dec 15.

Division of Pulmonary, Allergy and Critical Care, Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Seizure 2018 Nov 29;64:45-49. Epub 2018 Nov 29.

School of Medicine, College of Medical & Veterinary Life Sciences, University of Glasgow, United Kingdom; Paediatric Neurosciences Research Group & EEG Department, Royal Hospital for Children, Glasgow, United Kingdom. Electronic address:

Purpose: To evaluate the clinical utility of the ambulatory electroencephalogram (AEEG) in children.

Method: Data from 199 consecutive referrals for a paediatric AEEG were reviewed retrospectively. Information was gathered on various aspects of the referral process, the characteristics of the children referred and the reasons for referral. Read More

Sleep Med 2018 Nov 22;54:134-141. Epub 2018 Nov 22.

Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. Electronic address:

Objective: To estimate the prevalence of poor sleep quality and identify related factors by gender in the Chinese rural population.

Methods: Overall, 27424 subjects (10881 males and 16543 females) aged 18-79 years were enrolled from the Henan Rural Cohort Study. Sleep quality was evaluated by the standard Pittsburgh Sleep Quality Index (PSQI) and global score>5 was classified as poor sleep quality. Read More

Sleep Med 2018 Nov 17;54:126-133. Epub 2018 Nov 17.

Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), N-7491 Trondheim, Norway; Department of Neurology and Clinical Neurophysiology, St. Olavs Hospital, N-7006 Trondheim, Norway.

Background: The relationship between insomnia and objectively measured obstructive sleep apnea (OSA) severity has not previously been investigated in both genders in the general population. The main aim of this population-based polysomnography (PSG) study was to evaluate the cross-sectional association between severity of OSA and DSM-V insomnia and insomnia severity.

Methods: A random sample of 1200 participants in the third Nord-Trøndelag Health Study (HUNT3) was invited and 213 (18%) aged between 21 and 82 years underwent an ambulatory PSG, a semi-structured interview, and a sleep-specific questionnaire. Read More

Sleep Med 2018 Nov 14;54:121-125. Epub 2018 Nov 14.

Department of Epidemiology, Nara Medical University School of Medicine, Nara, Japan.

Objectives: To evaluate the associations between pre-awake light (PAL) exposure and subjective and objective measures of sleep quality.

Methods: In this cross-sectional study of 1108 elderly participants (mean age, 71.9 years), we measured bedroom light intensity using a bedside light meter for two nights and sleep quality using actigraphy and a questionnaire. Read More

Gait Posture 2018 Dec 6;68:311-316. Epub 2018 Dec 6.

Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, NV, USA; Department of Neurology and Neurological Sciences, Stanford University, USA. Electronic address:

Background: The etiology of freezing of gait in Parkinson's disease (PD) is yet to be clarified. Non-motor risk factors including cognitive impairment, sleep disturbance and mood disorders have been shown in freezing of gait.

Research Question: We aimed to determine the predictive value of non-motor features in freezing of gait development. Read More

J Crit Care 2018 Dec 8;50:188-194. Epub 2018 Dec 8.

Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Emory University, Atlanta, GA, United States.

Introduction: Despite international guidelines, regional differences in treatment of vasodilatory shock remain. We characterized these differences using data from Angiotensin II in High Output Shock (ATHOS-3) trial.

Methods: The 321 patients treated in the ATHOS-3 trial were included. Read More

Respir Physiol Neurobiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Medicine, Bnai-Zion Medical Centre, Haifa, Israel; Rappaport School of Medicine, Technion Institute of Technology, Haifa, Israel. Electronic address:

Introduction: In addition to dyscoordination of upper airway dilator muscles activity, sleep may also alter the pattern of intra-muscular activation of single motor units (SMUs). Such changes should be identifiable by a state dependent change in EMG power spectrum, i.e. Read More

J Shoulder Elbow Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Orthopaedic Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Background: Shoulder arthroscopy is a common orthopedic procedure typically performed on an outpatient basis. Occasionally, patients require an unplanned hospital admission. An understanding of the incidence and risk factors for admission after shoulder arthroscopy may assist surgeons in determining which patients may be susceptible to unplanned admission after surgery. Read More

Neuroscience 2018 Dec 13. Epub 2018 Dec 13.

Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China. Electronic address:

γ oscillations (30-120 Hz) are generated intrinsically within local networks in the mammalian olfactory bulb (OB). The OB directly receives peripheral input from olfactory sensory neurons (OSNs) that can respond to nasal airflow, and centrifugal input from neuromodulatory systems whose activities are affected by the behavioral states of animal. How peripheral and centrifugal input dynamically modulate γ oscillations is unclear. Read More

Sleep Med 2018 Oct 17. Epub 2018 Oct 17.

Department of Neuroscience, Sleep Research Laboratory, Uppsala University, Uppsala, Sweden.

Am J Otolaryngol 2018 Dec 6. Epub 2018 Dec 6.

The Department of Otolaryngology-Head and Neck Surgery, The First Hospital of Jilin University, Changchun, 130000, Jilin Province, China. Electronic address:

Purpose: To explore the impact of H-uvulopalatopharyngoplasty (H-UPPP) in obstructive sleep apnea syndrome (OSAS) and gain insights into the potential mechanism underlying improvement by H-UPPP.

Methods: In a cohort of 11 OSAS patients, computational fluid dynamics (CFD) models of the upper airway were obtained using commercial software from computed tomography (CT) datasets before and after H-UPPP. Morphological and numerical parameters were respectively computed and compared during the peak tidal inspiratory flow. Read More