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Fortschr Neurol Psychiatr 2019 Apr 18;87(4):259-270. Epub 2019 Apr 18.

Long-term prescriptions of benzodiazepines are made mainly to elderly and female patients. Withdrawal treatments should be carried out gradually over a period of several weeks. Sleep and depressive disorders during benzodiazepine withdrawal can best be treated with sedating antidepressants. Read More

Ecotoxicol Environ Saf 2019 Apr 15;178:94-104. Epub 2019 Apr 15.

State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 211198, PR China; School of Life Science and Technology, China Pharmaceutical University, Nanjing, 211198, PR China; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210023, PR China. Electronic address:

Light is involved in many critical physiological or biochemical processes of human beings, such as visual sensing and the production of vitamin D. Recent studies have showed that the lights of different wavelengths have a profound influence in life activities. For example, blue light promotes alertness, whereas green light (GL) induces sleep in mice. Read More

Life Sci 2019 Apr 15. Epub 2019 Apr 15.

Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.

Aims: The current study aims to evaluate the possible protective effect of omega-3 fatty acids on memory impairment induced by sleep-deprivation in rats.

Materials And Methods: Animals were chronically sleep deprived using the modified multiple platform model (8 h/day for 8 weeks). Omega-3 fatty acids were administered as fish oil via oral gavage at a daily dose of 100 mg omega-3 PUFA/100 g BWT. Read More

Brain Res 2019 Apr 15. Epub 2019 Apr 15.

Student's Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran; NeuroImaging Network (NIN), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Electronic address:

Narcolepsy (NA) is a primary sleep disorder characterized by loss of hypocretinergic/orexinergic neurons. NA is associated with an increased risk for metabolic disorders such as diabetes mellitus (DM). Proposed mechanisms for this association are alterations in food intake, disruption of energy balance, glucose tolerance, and insulin sensitivity, as well as inflammation and genetic factors. Read More

Am J Med 2019 Apr 15. Epub 2019 Apr 15.

Department of Medicine, Boston University School of Medicine, Boston, MA.

Chest 2019 Apr 15. Epub 2019 Apr 15.

Department of Radiation Oncology, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston TX, USA.

Radiation-induced lung injury (RILI) encompasses any lung toxicity induced by radiation therapy (RT) and manifests acutely as radiation pneumonitis (RP) and chronically as radiation pulmonary fibrosis (RPF). Since most patients with thoracic and breast malignancies are expected to undergo RT in their lifetime, many with curative intent, the population at risk is significant. Further, indications for thoracic RT are expanding given the advent of stereotactic body radiation therapy or stereotactic ablative radiotherapy (SBRT/SABR) for early stage lung cancer in non-surgical candidates as well as oligometastatic pulmonary disease from any solid tumor. Read More

PLoS One 2019 18;14(4):e0215530. Epub 2019 Apr 18.

Department of Epidemiology and Biostatistics, School of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of Congo.

Background: The ultimate goal of asthma treatment is long-term control. Uncontrolled asthma is a major public health problem worldwide, but there is a lack of data on asthma control and its causes in the Democratic Republic of Congo (DRC).

Objective: To determine the socio-demographic, environmental, clinical, and biological factors and comorbidities associated with uncontrolled adult asthma in Kinshasa, DRC. Read More

PLoS One 2019 18;14(4):e0215345. Epub 2019 Apr 18.

Department of Psychiatry, Nihon University School of Medicine, Tokyo, Japan.

Background: A scientific understanding of the effects of seasonal changes on sleep duration and sleep problems such as insomnia and hypersomnia has yet to be elucidated; however, such an understanding could aid the establishment of an optimal sleep hygiene program to treat such problems.

Methods: We investigated the effects of seasonal changes on sleep duration and sleep problems in Japanese community residents. Data on 1,388 individuals aged 15-89 years who participated in the Survey of Seasonal Variations in Food Intakes conducted by the National Institute of Health and Nutrition of Japan (2004-2007) were analyzed. Read More

PLoS One 2019 18;14(4):e0215374. Epub 2019 Apr 18.

Department of Pain, Lanzhou University Second Hospital, Lanzhou, Gansu Province, People's Republic of China.

This study is to identify the risk factors for postoperative delirium (PODE) in patients undergoing microvascular decompression (MVD) for the treatment of primary cranial nerve disorders. We retrospectively reviewed the data of 912 patients (354 men, 558 women) with primary cranial nerve disorders (trigeminal neuralgia, 602 patients; hemifacial spasm, 296 patients; glossopharyngeal neuralgia, 14 patients) who underwent MVD in the Neurosurgery Department of Lanzhou University Second Hospital between July 2007 and June 2018. Potential risk factors for PODE were identified using univariate and multivariate stepwise logistic regression analysis. Read More

PLoS Comput Biol 2019 Apr 18;15(4):e1006968. Epub 2019 Apr 18.

Department of Computer Science, ETH Zurich, Zürich, Switzerland.

Understanding sleep and its perturbation by environment, mutation, or medication remains a central problem in biomedical research. Its examination in animal models rests on brain state analysis via classification of electroencephalographic (EEG) signatures. Traditionally, these states are classified by trained human experts by visual inspection of raw EEG recordings, which is a laborious task prone to inter-individual variability. Read More

Eur J Sport Sci 2019 Apr 18:1-9. Epub 2019 Apr 18.

a Sport & Exercise Discipline Group , University of Technology Sydney , Moore Park , Australia.

Objectives: To investigate player responses 48 h post single (SM) and multi-match (MM) weeks on two subjective and three objective outcome measures to infer recovery status.

Methods: From 42 professional players over 2 seasons, outcome measures relevant to recovery status were collected 48 h following matches, as well as during pre-season training weeks as a comparative baseline. These included (1) 5-item subjective wellness questionnaire, (2) total quality recovery (TQR) scale, (3) hip adduction squeeze test, ankle knee to wall (KTW) test, and active knee extension (AKE) flexibility test. Read More

J Clin Endocrinol Metab 2019 Apr 18. Epub 2019 Apr 18.

Dutch Growth Research Foundation, Rotterdam, The Netherlands.

Context: Sleep-related breathing disorders (SRBD) are common in people with Prader-Willi syndrome (PWS). Young adults with PWS benefit from GH continuation after adult height by maintaining the improved body composition obtained during childhood. There are, however, no studies about the effects of GH on SRBD in young adults with PWS who were treated with GH during childhood. Read More

J Appl Physiol (1985) 2019 Apr 18. Epub 2019 Apr 18.

School of Physical Therapy, Graduate Institute of Rehabilitation Science, China Medical University, Taiwan.

Background: This study was to investigate the effects of exercise training on anti-apoptotic pathways and mitochondrial biogenesis in ovariectomized hypertensive rats.

Methods: Histopathological analysis, TUNEL assay and Western blotting were performed on the excised hearts from female spontaneously hypertensive rats (SHR), which were divided into a sham-operated sedentary hypertensive (SHR-S), a sedentary hypertensive ovariectomized (SHR-O), and hypertensive ovariectomized rats which underwent treadmill exercise training (SHR-OT, 60 min/day, 5 days/week) for 8 weeks, along with normotensive Wistar Kyoto rats (WKY).

Results: When compared with the WKY group, the SHR-S group exhibited decreased protein levels of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) and mitochondrial OPA-1 (mitochondrial biogenesis) and decreased further in the SHR-O group. Read More

Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 2019 Apr 18:1-12. Epub 2019 Apr 18.

a The Healthy Brain Ageing Clinic, School of Psychology , The University of Sydney , Camperdown , NSW , Australia.

Cardiovascular disease in older people is often linked with cognitive impairment, particularly in domains of executive function and processing speed. Our aims examined whether carotid-femoral pulse wave velocity (PWV) related to subtle changes of executive function and processing speed. Fifty-six individuals with subjective mood and/or cognitive concerns underwent PWV and neuropsychological assessments of processing speed (Trail Making Test Part A) and executive functioning (Delis Kaplan Executive Function System Stroop Task; Trail Making Test Part B, TMT-B). Read More

Future Oncol 2019 Apr 18. Epub 2019 Apr 18.

Department of Radiology and Oncology, University Kebangsaan Malaysia Medical Centre, Hospital Canselor Tunku Muhriz, Wilayah Persekutuan Kuala Lumpur, Malaysia.

The present study investigated the relationship between psychological problems, illness acceptance and cancer-related complaints among Malaysian cancer patients. One-hundred and six cancer patients were recruited and were requested to complete validated self-reported questionnaires that measured their psychological distresses, sleep quality, pain, fatigue and illness acceptance. There was a significant relationship between cancer-related symptoms, illness acceptance and psychological distresses commonly experienced by local cancer patients (p < 0. Read More

J Med Virol 2019 Apr 17. Epub 2019 Apr 17.

Sleep Medicine Center, Shantou University Medical College, Shantou, Guangdong, China.

Accumulating evidence suggests that infections by herpesviruses might be closely linked to Alzheimer's disease (AD). Pathological hallmarks of AD brains include senile plaques induced by amyloid β peptide (Aβ) in the extracellular space and intracellular neurofibrillary tangles (NFTs) consisting of phosphorylated tau protein. The prevailing hypothesis for the mechanism of AD is amyloid cascade reaction. Read More

J Neurol 2019 Apr 17. Epub 2019 Apr 17.

King's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Basic and Clinical Neurosciences, De Crespigny Park, London, SE5 8AF, UK.

Objective: To identify associated (non-)motor profiles of Parkinson's disease (PD) patients with hyperhidrosis as a dominant problem.

Methods: This is a cross-sectional, exploratory, analysis of participants enrolled in the Non-motor Longitudinal International Study (NILS; UKCRN No: 10084) at the Parkinson's Centre at King's College Hospital (London, UK). Hyperhidrosis scores (yes/no) on question 28 of the Non-Motor Symptom Questionnaire were used to classify patients with normal sweat function (n = 172) and excessive sweating (n = 56) (Analysis 1; n = 228). Read More

Eur Arch Otorhinolaryngol 2019 Apr 17. Epub 2019 Apr 17.

Department of Otorhinolaryngology Head and Neck Surgery, Police General Hospital, 492/1 Rama 1 Road, Patumwan, Bangkok, Thailand.

Objective: To conduct a systematic review and meta-analysis in children with syndromic craniosynostosis, to evaluate the effect of adenotonsillectomy for the treatment of obstructive sleep apnea (OSA).

Study Design: A systematic review and meta-analysis.

Search Methods: Data sources: a comprehensive search of PubMed, SCOPUS, Ovid Medline, and Web of science databases was performed through June 22nd, 2018. Read More

Open Med (Wars) 2019 4;14:307-316. Epub 2019 Apr 4.

Department of Neurology, Faculty of Medicine, University of Debrecen, Debrecen, Egyetem tér 1, H-4032, Hungary.

Background: Behavioural and psychological symptoms in dementia (BPSD) form an important sub-syndrome of dementia. We assessed the frequency and severity of BPSD in a random sample of Hungarian treatment-naïve dementia patients. Furthermore, we examined the relationship between cognitive symptoms and BPSD and the pattern of BPSD in specific types of dementias. Read More

J Thorac Dis 2019 Mar;11(Suppl 3):S480-S482

CNR, Institute of Biomedicine and Molecular Immunology, Palermo, Italy.

J Thorac Dis 2019 Mar;11(Suppl 3):S202-S206

Department of Anaesthesia and Critical Care Medicine, Policlinico Umberto 1 Hospital, Sapienza University of Rome, Rome, Italy.

Ger Med Sci 2019 22;17:Doc02. Epub 2019 Feb 22.

Department of Internal Medicine II, University Hospital Ulm, Germany.

The current gold standard for assessment of most sleep disorders is the in-laboratory polysomnography (PSG). This approach produces high costs and inconveniences for the patients. An accessible and simple preliminary screening method to diagnose the most common sleep disorders and to decide whether a PSG is necessary or not is therefore desirable. Read More

Can J Respir Ther 2018 1;54(2):35-40. Epub 2018 Aug 1.

Pulmonology Department, Centro Hospitalar São João, Oporto, Portugal.

Introduction: Recent studies have reported a high prevalence of obstructive sleep apnoea (OSA) among patients with diffuse parenchymal lung disease (DPLD), mainly idiopathic pulmonary fibrosis (IPF). Effective OSA treatment appears to have a positive impact on morbidity and mortality in these patients. However, poor compliance to positive airway pressure (PAP) treatment in fibrotic DPLD patients has been reported. Read More

J Maxillofac Oral Surg 2019 Jun 27;18(2):299-306. Epub 2018 Aug 27.

1Department of Otolaryngology Head & Neck Surgery and Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, 6 Weizman St., Tel-Aviv, 6423906 Israel.

Introduction: The impact of the dimensional parameters of the pharyngeal bony frame by its length, width and the position of the hyoid upon the severity of obstructive sleep apnea syndrome (OSAS) has not been investigated in depth. Interactions of those parameters with body mass index (BMI) and their overall reciprocal effect on OSAS severity have also not been established.

Materials And Methods: This retrospective cross-sectional study was conducted on 108 male OSAS patients followed in OSAS outpatient clinics between November 2014 and October 2015. Read More

J Maxillofac Oral Surg 2019 Jun 5;18(2):256-259. Epub 2018 Mar 5.

1Oral and Maxillofacial Surgery, National Dental College, Derabassi, Punjab India.

Purpose: The aim of the study was to compare the efficacy of oral lorazepam as night sedation and premedication with diazepam.

Methods: A prospective, randomized, and double-blind study was done in 50 healthy patients in each drug group. The impacted third molar impaction was taken as the study model. Read More

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):252-255

Department of Respiratory and Critical Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing 100023, China.

Objective: Growing evidence indicates that both chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) may be related to increased risk of developing metabolic disorder and cardiovascular diseases. However, the association of sleep overlap syndrome (combination of COPD and OSA) with type 2 diabetes is unclear. The aim of this study was to investigate the association between overlap syndrome and prevalence of type 2 diabetes. Read More

Sci Rep 2019 Apr 17;9(1):6206. Epub 2019 Apr 17.

Division of Allergy & Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

There is an increasing prevalence of esophageal diseases but intact human tissue platforms to study esophageal function, disease mechanisms, and the interactions between cell types in situ are lacking. To address this, we utilized full thickness human donor esophagi to create and validate the ex vivo function of mucosa and smooth muscle (n = 25). Explanted tissue was tested for contractile responses to carbachol and histamine. Read More

Sci Rep 2019 Apr 17;9(1):6218. Epub 2019 Apr 17.

Yale University, New Haven, CT, USA.

Focal slowing (<4 Hz) of brain waves is often associated with focal cerebral dysfunction and is assumed to be increased closest to the location of dysfunction. Prior work suggests that slowing may be comprised of at least two distinct neural mechanisms: slow oscillation activity (<1 Hz) may reflect primarily inhibitory cortical mechanisms while power in the delta frequency (1-4 Hz) may correlate with local synaptic strength. In focal epilepsy patients, we examined slow wave activity near and far from the seizure onset zone (SOZ) during wake, sleep, and postictal states using intracranial electroencephalography. Read More

Ind Health 2019 Apr 17. Epub 2019 Apr 17.

Sleep/Wake Research Centre, Massey University, New Zealand.

Knowledge about cabin crew fatigue associated with ultra-long range (ULR) flights is still limited. Current ULR scheduling for cabin crew is therefore predominantly based on flight crew data. Cabin crews' views on fatigue, and their strategies for mitigating it, have seldom been sought. Read More

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Sleep Medicine and Sleep Disorders Center, Aichi Medical University Hospital, Japan.

Objective The association between narcolepsy and rapid eye movement (REM)-related obstructive sleep apnea (OSA) has not been reported. This study aimed to examine the prevalence of REM-related OSA in narcolepsy patients. Methods From January 2013 to April 2018, 141 adult patients were diagnosed with narcolepsy using nocturnal polysomnography and the multiple sleep latency test. Read More

Respiration 2019 Apr 17:1-5. Epub 2019 Apr 17.

University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA.

Background: Excessive drop of pleural pressure (Ppl) during therapeutic thoracentesis may be related to adverse events and/or to repeated procedures due to incomplete drainage.

Objective: This was a pilot study of the impact of the application of continuous positive airway pressure (CPAP) at +5 cm H2O upon the Ppl profile during thoracentesis.

Methods: This was a prospective, controlled study of 49 consecutive adults who underwent thoracentesis. Read More

Depress Anxiety 2019 Apr 17. Epub 2019 Apr 17.

Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, Illinois.

Background: Evidence-based treatments for post-traumatic stress disorder (PTSD) have poor uptake and remission rates, suggesting that alternative treatments are needed. Morning bright light may be an effective treatment for PTSD given its established effects on mood and sleep, however, there are no published trials.

Methods: We conducted a placebo-controlled pilot trial of a wearable light device, the Re-timer®, for individuals with probable PTSD. Read More

J Bone Miner Res 2019 Apr 17. Epub 2019 Apr 17.

Veterans Affairs Nebraska-Western Iowa Health Care System, Research Service, Omaha, NE.

Objectives: Rheumatoid Arthritis (RA) is characterized by extra-articular involvement including lung disease, yet the mechanisms linking the two conditions are poorly understood. The collagen-induced arthritis (CIA) model was combined with the organic dust extract (ODE) airway inflammatory model to assess bone/joint-lung inflammatory outcomes.

Methods: DBA/1J mice were intranasally treated with saline or ODE daily for 5 weeks. Read More

PLoS One 2019 17;14(4):e0215355. Epub 2019 Apr 17.

German Armed Forces Hospital Hamburg, Centre for Mental Health, Hamburg, Germany.

Background: This study compares the sleep architecture of patients with posttraumatic stress disorder (PTSD) with that of both patients with depression and subjects with no mental disorder.

Method: 45 German armed forces personnel with PTSD, 72 German armed forces personnel with depression and 24 healthy control subjects underwent 24-hour polysomnography. The effects of group membership, medication and the statistical interaction of group and medication were analysed for the following variables: sleep onset latency, REM sleep latency, slow-wave sleep and REM sleep percentages. Read More

Int J Adolesc Med Health 2019 Apr 17. Epub 2019 Apr 17.

Department of Preventive and Social Medicine, Jawaharlal Institute of Post Graduate Medical Education, Pondicherry, India.

Background Adolescence is a critical stage of life which is characterized by rapid biological, social and emotional development. India has the highest adolescent population, however, there is paucity of literature reporting the sleep quality among adolescents. Objective To determine the sleep quality and its associated factors among adolescents residing in selected villages of rural Puducherry. Read More

J Neurophysiol 2019 Apr 17. Epub 2019 Apr 17.

Biology II, LMU Munich, Germany.

It is generally thought that apart from receptive field differences, such as preferred orientation and spatial frequency selectivity, primary visual cortex neurons are functionally similar to each other. However the genetic diversity of cortical neurons plus the existence of inputs additional to those required to explain known receptive field properties, might suggest otherwise. Here we report the existence of desynchronised states in anesthetised cat area 17 lasting up to 45 minutes, characterised by variable narrow-band local field potential (LFP) oscillations in the range 2 - 100 Hz and the absence of a synchronised 1/f frequency spectrum. Read More

Am J Respir Cell Mol Biol 2019 Apr 17. Epub 2019 Apr 17.

University of Groningen, University Medical Center Groningen, Pathology and Medical Biology, Groningen, Netherlands.

Lung disease accounts for every sixth death globally. Profiling the molecular state of all lung cell types in health and disease is currently revolutionizing the identification of disease mechanisms and will aid the design of novel diagnostic and personalized therapeutic regimens. Recent progress in high-throughput techniques for single-cell genomic and transcriptomic analyses has opened up new possibilities to study individual cells within a tissue, classify these into cell types, and characterize variations in their molecular profiles as a function of genetics, environment, cell-cell interactions, developmental processes, ageing or disease. Read More

Am J Respir Crit Care Med 2019 Apr 17. Epub 2019 Apr 17.

Cook County Health and Hospital Systems, Division of Pulmonary, Critial Care, and Sleep Medicine, Chicago, Illinois, United States ;

Braz J Psychiatry 2019 Apr 15. Epub 2019 Apr 15.

Departamento e Instituto de Psiquiatria, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.

Objective: To examine predictors associated with quality of life (QoL) in Brazilian medical students.

Methods: PubMed, PsycINFO, EMBASE, LILACS, and Google Scholar were searched for research articles in English or Portuguese published through August 2018. Observational studies that measured QoL with standard instruments were selected. Read More

Rev Assoc Med Bras (1992) 2019 Mar 11;65(3):375-383. Epub 2019 Apr 11.

Department of Psychobiology, Federal University of Sao Paulo, Sao Paulo, SP, Brasil.

Objective: This study aims to evaluate the sleep of subjects with polycystic ovary syndrome (PCOS), with and without hyperandrogenism, in comparison with a healthy control group and examine the effects of hyperandrogenism and obesity on sleep parameters.

Methods: A total of 44 volunteers were recruited to participate in the study. Clinical, biochemical and polysomnographic parameters were used to diagnose PCOS and hyperandrogenism. Read More

An Acad Bras Cienc 2019 8;91(1):e20180107. Epub 2019 Apr 8.

Departamento de Ciências do Movimento Humano, Universidade Federal de São Paulo/UNIFESP, Rua Silva Jardim, 136, 11015-020 Santos, SP, Brazil.

This study investigated the effect of the intake of high (HGI) or low glycemic index (LGI) high-carbohydrate meals on athletes' sleep. Nine basketball adult male athletes were assessed during a championship and received high-carbohydrate meals (dinner and evening snack) with HGI or LGI. Quantitative and qualitative sleep variables were assessed: sleep latency (LAT), sleep efficiency (EFIC), Wake After Sleep Onset (WASO), sleep time through actigraphy and sleep diary. Read More

Menopause 2019 Apr 15. Epub 2019 Apr 15.

School of Nursing, Indiana University, Indianapolis, IN.

Objective: Women's sleep at menopause is widely reported to be problematic. The Insomnia Severity Index (ISI) is a commonly used tool for quantifying sleep problems in clinical and research settings, but psychometric properties in postmenopausal women have not been reported. Our study aim was to examine the factor structure of the ISI in a large and diverse sample of midlife women with hot flashes. Read More

Anesthesiology 2019 May;130(5):777

J Med Internet Res 2019 Apr 17;21(4):e11029. Epub 2019 Apr 17.

Korea University College of Medicine, Department of Psychiatry, Seoul, Republic of Korea.

Background: Virtually, all organisms on Earth have their own circadian rhythm, and humans are no exception. Circadian rhythms are associated with various human states, especially mood disorders, and disturbance of the circadian rhythm is known to be very closely related. Attempts have also been made to derive clinical implications associated with mood disorders using the vast amounts of digital log that is acquired by digital technologies develop and using computational analysis techniques. Read More

Sleep 2019 Apr 17. Epub 2019 Apr 17.

Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO.

Study Objectives: To evaluate the associations between sedentary time, total (total-PA), light (light-PA), moderate (MOD-PA), and vigorous (VIG-PA) physical activity with indices of sleep in postmenopausal women.

Methods: Baseline self-reported data from the Women's Health Initiative Observational Study (n=75,074) were used in this cross-sectional analysis. Total-PA, light-PA, MOD-PA, and VIG-PA were categorized by metabolic equivalents of the activity [MET-hour (hr)/week (wk)] and were estimated using validated questionnaires. Read More

Sleep 2019 Apr 17. Epub 2019 Apr 17.

Departments of Medicine, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School.

Study Objectives: Sleep disturbances and sleep apnea are associated with increased vulnerability to age-related disease, altering molecular pathways affecting biological aging. Telomere length captures one component of biological aging. We evaluated whether objectively assessed sleep and sleep apnea relate to leukocyte telomere length (LTL) in the Multi-Ethnic Study of Atherosclerosis (MESA). Read More

Sleep 2019 Apr 17. Epub 2019 Apr 17.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.

Study Objectives: Although sleep duration and quality were significant risk factors of type 2 diabetes (T2D), the impact of sleep initiation time on the development of T2D has not been studied in large longitudinal studies.

Methods: A total of 3,689 subjects without diabetes aged 40-69 years at baseline were enrolled from the Korean Genome and Epidemiology Study and followed up for 12 yrs. Participants were categorized based on habitual sleep initiation time by questionnaire as follows: 20:00-22:59 (early sleepers, ES, n=766), 23:00-24:59 (usual sleepers, US, n=2,407), and 1:00-5:59 (late sleepers, LS, n=516). Read More

Diabetes Metab J 2019 Apr;43(2):144-155

Epidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA.

Obstructive sleep apnea (OSA) and diabetes has been known to be closely related to each other and both diseases impact highly on the public health. There are many evidence of reports that OSA is associated with diabetes with a bidirectional correlation. A possible causal mechanism of OSA to diabetes is intermittent hypoxemia and diabetes to OSA is microvascular complication. Read More

Laryngoscope 2019 Apr 17. Epub 2019 Apr 17.

Otolaryngology Department, Western University, London, Ontario, Canada.

Objectives/hypothesis: Our objective was to determine whether drug-induced sleep apnea (DISE) affects the successfulness of the surgical outcome.

Study Design: Prospective, seven-country, nonrandomized trial.

Methods: There were 326 consecutive obstructive sleep apnea (OSA) patients who had nose, palate, and/or tongue surgery included in the study. Read More