Search Our Scientific Publications & Authors

World Neurosurg 2021 May 8. Epub 2021 May 8.

Department of Neurosurgery, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; "Aldo Ravelli" Research Center, Milan, Italy; Department of Medical-Surgical Physiopathology and Transplantation, University of Milan, Milan, Italy.

Objective: This study aims to assess the feasibility and reliability of our endoscopic trans-nasal technique for the repair of cribriform and sellar high-flow CSF leaks.

Methods: A comparison between patients suffering from high-flow rhinorrhea and treated through a free grafting endoscopic technique or the "parachute" technique, our nasal packing proposal, was performed.

Results: Thirty-three patients were included. Read More

World Neurosurg 2021 May 8. Epub 2021 May 8.

Department of Otolaryngology - Head and Neck Surgery, University of California, Irvine, Orange, CA, USA;; Department of Neurological Surgery, University of California, Irvine, Orange, CA, USA;. Electronic address:

Objective: Osteosarcomas of the skull base are rare and aggressive tumors that are most commonly treated with primary surgical resection and adjuvant chemoradiation. Using the National Cancer Database (NCDB), we analyzed demographic and clinical prognosticators for overall survival (OS).

Methods: The NCDB was queried for cases of histologically confirmed skull base osteosarcoma treated between 2004 and 2015, excluding patients receiving palliation or having less than 1 month of follow-up. Read More

World Neurosurg 2021 May 8. Epub 2021 May 8.

Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address:

Background: Histological grade has important implications for the management in meningioma. It is important to understand the risk of high-grade meningioma (Grade II and III). In this article, we systematically reviewed the histological grade of meningioma depending on the location and the sex, and its relationship with recurrence. Read More

Otol Neurotol 2021 May 10. Epub 2021 May 10.

Department of Otolaryngology Head and Neck Surgery, Washington University School of Medicine in St. Louis, St. Louis, Missouri Department of Otolaryngology Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, Kansas Department of Otolaryngology, Medizinische Hochschule Hannover, Hannover Cluster of Excellence "Hearing4all" of the German Research Foundation (EXC 1077), Germany.

Hypothesis: MicroRNAs predicted to regulate neurotrophin signaling can be found in human perilymph.

Background: Animal and human temporal bone studies suggest that spiral ganglion health can affect cochlear implant (CI) outcomes. Neurotrophins have been identified as a key factor in the maintenance of spiral ganglion health. Read More

Head Neck 2021 May 11. Epub 2021 May 11.

Department of Otolaryngology - Head & Neck Surgery, M. D. Anderson Cancer Center, Houston, Texas, USA.

The incidence of cerebrospinal fluid leak after ventral skull base reconstruction is a primary outcome of interest to skull base surgeons. Exposure to pre-operative radiation may put patients at an increased risk of skull base reconstructive failure. A systematic search identified studies which included patients receiving ventral skull base reconstruction in the setting of pre-operative radiation. Read More

Pituitary 2021 May 10. Epub 2021 May 10.

Division of Neurosurgery, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.

Purpose: Postoperative cerebrospinal fluid rhinorrhoea (CSFR) remains a frequent complication of endonasal approaches to pituitary and skull base tumours. Watertight skull base reconstruction is important in preventing CSFR. We sought to systematically review the current literature of available skull base repair techniques. Read More

Sci Rep 2021 May 10;11(1):9838. Epub 2021 May 10.

Department of Biomedical Engineering, University of Texas at Austin, 1 University Station, BME 5.202D, C0800, Austin, TX, 78712, USA.

Physical activity has been consistently linked to decreased incidence of breast cancer and a substantial increase in the length of survival of patients with breast cancer. However, the understanding of how applied physical forces directly regulate breast cancer remains limited. We investigated the role of mechanical forces in altering the chemoresistance, proliferation and metastasis of breast cancer cells. Read More

Mol Cell Biol 2021 May 10. Epub 2021 May 10.

Medical School, University of Crete, Heraklion, Crete, 71003, Greece

ETS2 repressor factor (ERF) haploinsufficiency causes late onset craniosynostosis (OMIM 600775; CRS4) in humans while in mice Erf-insufficiency also leads to a similar multi-suture synostosis phenotype preceded by mildly reduced calvarium ossification. However, neither the cell types affected nor the effects per se have been identified so far. Here we establish an system for the expansion of suture-derived mesenchymal stem and progenitor cells (sdMSCs) and analyze the role of Erf levels in their differentiation. Read More

World J Surg Oncol 2021 May 10;19(1):146. Epub 2021 May 10.

Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, 266003, China.

Background: This study aimed to identify the characteristic radiological signs for the diagnosis of Langerhans cell histiocytosis (LCH) of the bone.

Methods: We retrospectively studied 82 cases of LCH with bone lesions confirmed by pathology. Clinical and radiological features of the patients were analyzed. Read More

J Epidemiol Glob Health 2021 Apr 26. Epub 2021 Apr 26.

Directorate of Drug Store, Injection Section, Directorate General of Medical Supplies, Muscat, Sultanate of Oman.

Objective: Little information is available about the etiology, pathophysiology, risk factors, and epidemiologic features of Bone Tuberculosis (Bone-TB). In this work, we present the epidemiological data about the Bone-TB in the Sultanate of Oman.

Methods: Retrospectively, we identified and assessed those patients who were diagnosed with Bone-TB between January 2002 and December 2019 at Khoula Hospital. Read More

Vet Surg 2021 May 10. Epub 2021 May 10.

Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.

Objective: Design 3D printed skull contoured brain biopsy guides (3D-SCGs) from computed tomography (CT) or T1-weighted magnetic resonance imaging (T1W MRI).

Study Design: Feasibility study.

Sample Population: Five beagle dog cadavers and two client-owned dogs with brain tumors. Read More

World J Clin Cases 2021 Apr;9(12):2791-2800

Department of Neurosurgery, The First Affiliated Hospital of Shantou University Medical College, Shantou 515041, Guangdong Province, China.

Background: Malignant pheochromocytoma with cerebral and skull metastasis is a very rare disease. Combining our case with 16 previously reported cases identified from a PubMed search, an analysis of 17 cases of malignant cerebral pheochromocytoma was conducted. This literature review aimed to provide information on clinical manifestations, radiographic and histopathological features, and treatment strategies of this condition. Read More

Front Vet Sci 2021 22;8:603775. Epub 2021 Apr 22.

Office of Information Technology, University of Tennessee, Knoxville, TN, United States.

Computed tomography (CT) is the imaging modality of choice to evaluate patients with acute head trauma. However, magnetic resonance imaging (MRI) may be chosen in select cases. The objectives of this study were to evaluate the agreement of MRI with CT in the assessment for presence or absence of acute skull fractures in a canine and feline cadaver model, compare seven different MRI sequences (T1-W, T2-W, T2-FLAIR, PD-W, T2-W, "SPACE" and "VIBE"), and determine agreement of four different MRI readers with CT data. Read More

Front Pediatr 2021 23;9:561654. Epub 2021 Apr 23.

Department of Surgery, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea.

Unpowered scooters for recreation and transportation are popular among children. However, to date, there have been no studies on scooter-related injuries in Korea. This study aimed to assess the frequency and injury pattern with unpowered scooters and to propose prevention strategies. Read More

Neurol Clin Pract 2021 Feb;11(1):6-12

Department of Neurology (PGM), Brigham and Women's Hospital, Boston; Department of Neurology (PGM), Harvard Vanguard Medical Associates, Braintree; Division of Neurology (PGM), Cambridge Health Alliance; Harvard Medical School (PGM), Boston, MA; Department of Neurology (UN), West Virginia University, School of Medicine, Morgantown, WV; St. George's University (SK), School of Medicine, Grenada, WI; Hackensack Meridian School of Medicine at Seton Hall University (RK), Nutley; and Neuroscience Institute at Hackensack University Medical Center (RK), Hackensack, NJ.

Background: Occipital neuralgia (ON) is a paroxysmal disorder involving lancinating pain that originates in the neck or skull base with superior radiation toward the apex. ON more commonly occurs in patients with other coexisting headache disorders. There are limited data regarding the prevalence of ON. Read More

Gastroenterol Hepatol Bed Bench 2021 ;14(2):123-131

Department of Clinical Genetic, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran.

Aim: Efforts to explore biomarkers and biological pathways involved in the disease are needed to improve colorectal cancer (CRC) diagnosis and alternative treatments.

Background: The fourth common malignancy in the world is colorectal cancer. The over-all burden is predicted to rise by 2030. Read More

Front Pharmacol 2021 23;12:678322. Epub 2021 Apr 23.

Institute of Biomedicine and Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, China.

Patients with a skull defect are at risk of developing cerebrospinal fluid leakage and ascending bacterial meningitis at >10% per year. However, treatment with stem cells has brought great hope to large-area cranial defects. Having found that transforming growth factor (TGF)-β3 can promote the osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs), we designed a hybrid TGF-β3/recombinant human-like collagen recombinant human collagen/chitosan (CS) freeze-dried sponge (TRFS) loading hPDLSCs (TRFS-h) to repair skull defects in rats. Read More

Can Vet J 2021 May;62(5):505-508

Eastcott Referrals, Edison Park, Dorcan Way, Swindon SN3 3RB, Wiltshire, United Kingdom (Rossi, Sainato, Renfrew); Langford Vets, University of Bristol School of Veterinary Sciences, Langford House, Langford, Bristol, BS40 5DU, United Kingdom (Kumaratunga).

A 20-month-old neutered male dachshund dog was referred because of a 10-week history of swelling close to the medial canthus of the left eye. Recurrence of the lesion and cytological appearance of the fluid content were suggestive of inflammation. Computed tomography revealed a triangular-shaped bone defect in the skull deep to the lesion. Read More

Otol Neurotol 2021 Jun;42(5):e573-e578

Division of Otology/Neurotology-Skull Base Surgery, Department of Otolaryngology/Head and Neck Surgery, Michigan Medicine, The University of Michigan, Ann Arbor, Michigan.

Objective: Highlight the importance of establishing a differential diagnosis to identify and treat multiple origins of dizziness in a patient following traumatic brain injury (TBI).

Patient: 73-year-old man with TBI and temporal bone fracture developed posttraumatic bilateral multiple canal benign paroxysmal positional vertigo (BPPV).

Intervention: Multi-disciplinary diagnostic evaluation and vestibular rehabilitation (VR) treatment focused on canalith repositioning maneuvers (CRMs) and central adaptation. Read More

J Craniomaxillofac Surg 2021 Apr 24. Epub 2021 Apr 24.

Sackler School of Medicine,Tel Aviv University, Tel Aviv, Israel; Communication Disorders Faculty, Hadassah Academic College, Jerusalem, Israel.

The study aimed at assessing the relationship between skull base morphology, represented by skull base and nasopharyngeal angles, and palatal anatomy among patients with 22q11DS and velopharyngeal dysfunction. Retrospective analysis of patients with 22q11DS and velopharyngeal dysfunction. Age, sex, severity of velopharyngeal dysfunction, type of cleft (overt cleft palate, submucous cleft palate, occult submucous cleft palate, or no-CP, and cephalometric skull base angles were reviewed. Read More

J Laryngol Otol 2021 May 10:1-7. Epub 2021 May 10.

Department of Otolaryngology Head and Neck Surgery, Fiona Stanley Hospital, Murdoch, Australia.

Background And Objective: Spontaneous cerebrospinal fluid leak of the temporal bone is an emerging clinical entity for which prompt and accurate diagnosis is difficult given the subtle signs and symptoms that patients present with. This study sought to describe the key temporal bone abnormalities in patients with spontaneous cerebrospinal fluid leak.

Methods: A retrospective cohort study was conducted of adult patients with biochemically confirmed spontaneous cerebrospinal fluid leak. Read More

Ann Palliat Med 2021 Apr;10(4):4975-4981

Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China.

Primary malignant melanoma of the gastrointestinal mucosa is a rare tumor. Here, we report a case of a 60-year-old female patient with esophageal malignant melanoma. Combined with the related literature, the clinical manifestations, imaging, histopathological and immunohistochemical features of primary esophageal malignant melanoma were observed and analyzed. Read More

Breast Cancer Res Treat 2021 May 8. Epub 2021 May 8.

Division of Neurosurgery, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Shizuoka, Japan.

Purpose: While leptomeningeal metastasis (LM) from estrogen receptor-positive, HER2-negative advanced breast cancer (ER + HER2-ABC) has a poor prognosis, the details of ER + HER2-LM are unclear. We therefore retrospectively investigated patients with LM from ER + HER2-ABC.

Methods: ER + HER2-ABC patients who received any therapy at Shizuoka Cancer Center between October 2002 and December 2017 were retrospectively analyzed. Read More

Eur Arch Otorhinolaryngol 2021 May 8. Epub 2021 May 8.

Department of Neurosurgery, Medical University of Graz, Graz, Austria.

Objective: To evaluate the frequency, type and indications of nasal turbinate (NT) resection during endoscopic, anterior skull base surgery and to analyze factors that may have an impact on the need of NT removal.

Methods: In this retrospective cohort study, 306 subjects (150 males and 156 females, mean age 55.4 ± 15. Read More

Eur Neurol 2021 May 7:1-7. Epub 2021 May 7.

Professor, Institute of Social Science, I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, Moscow, Russian Federation.

In his serially published atlas of pathology, Anatomie Pathologique du Corps Humain (1829-1842), French anatomist and pathologist Jean Cruveilhier (1791-1874) provided an early clinical-pathologic description of Dyke-Davidoff-Masson syndrome. Cruveilhier's case was initially published around 1830, more than a century before the clinical and radiologic report of Dyke and colleagues in 1933 based on a series of patients studied with pneumoencephalography. Although Dyke and colleagues were apparently unaware of Cruveilhier's prior description, Cruveilhier's case manifested all of the key osseous and neuropathological features of Dyke-Davidoff-Masson syndrome as later elaborated by Dyke and colleagues: (1) cerebral hemiatrophy with ex vacuo dilation of the lateral ventricle, (2) ipsilateral thickening of the diploe of the skull, and (3) ipsilateral hyper-pneumatization of the frontal sinuses. Read More

J Neurosurg 2021 May 7:1-11. Epub 2021 May 7.

1Department of Neurosurgery, Beijing Tiantan Hospital, and.

Objective: Due to the proximity of craniopharyngioma to the optic apparatus, one of the most common complications after surgery is visual deterioration. Intraoperative visual evoked potential (VEP), as a means of real-time visual function monitoring, has been integrated into transsphenoidal surgery for pituitary adenoma to predict postoperative visual outcome. Compared with pituitary tumor, craniopharyngioma often adheres to optic nerves, with increased risk of postoperative visual impairment. Read More

Compend Contin Educ Dent 2021 Apr;42(4):g1-g4

Faculty Member, Advanced Education in General Dentistry Residency Program, University of Cincinnati Medical Center; Private Practice limited to Periodontics and Dental Implants, Milford, Ohio; Diplomate, American Board of Periodontology; Diplomate, International Congress of Oral Implantologists.

Fixed prostheses offer various advantages over conventional removable devices for immediate restoration of a fractured tooth in the esthetic zone. In this case report, a fixed solution is employed through the use of a same-day provisional restoration attached to an immediately placed dental implant. Utilizing biologics and an implant system that allows for excellent primary stability, this treatment modality offers a predictable method for achieving immediate implant placement and provisionalization. Read More

Compend Contin Educ Dent 2021 Apr;42(4):f1-f4

Master, Academy of General Dentistry; Diplomate, International Congress of Oral Implantologists; Private Practice, Silver Spring, Maryland.

Various materials have been used for extraction socket preservation in anticipation of implant placement or to limit resorption of socket walls. Materials have ranged from autogenous bone, allografts, and xenografts to synthetics. Ideally, the graft material being placed into the socket at the time of extraction should fully convert to host bone to yield vital bone that will permit implant osseointegration with as much contact between bone and the implant surface as possible. Read More

Br J Neurosurg 2021 May 7:1-14. Epub 2021 May 7.

Department of Neuroradiology, Great Ormond Street Hospital NHS Foundation Trust, London, UK.

Lesions of the paediatric cranial vault are diverse both in their presentation and aetiology. As such, they pose a diagnostic challenge to the paediatric neurosurgeon and neuroradiologist. In this article, we delineate the spectrum of paediatric calvarial pathology into four distinct groups: (1) lytic lesion(s); (2) focal sclerotic lesion(s); (3) diffuse cranial vault sclerosis; and (4) abnormal shape of the cranial vault. Read More

Compend Contin Educ Dent 2021 Apr;42(4):158-162

Private Practice, Chalfont, Pennsylvania.

Over time, patients treated in developmental stages of implantology may need additional treatment,as teeth adjacent to implants may fail and require replacement themselves with new implants. Blending newer implant rehabilitations into a dentition with existing implant-supported restorations can be challenging. The use of implants with a subcrestal angle correction (SAC) enables predictable screw-retained anchorage of temporary and definitive restorations. Read More