13,398 results match your criteria Skull Base Benign Tumors

The Influence of Hospital Volume on the Outcomes of Nasopharyngeal, Sinonasal, and Skull-Base Tumors: A Systematic Review of the Literature.

J Neurol Surg B Skull Base 2022 Jun 19;83(3):270-280. Epub 2021 Jan 19.

Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, United States.

 The center of excellence model of health care hypothesizes that increased volume in a specialized center will lead to better and more affordable care. We sought to characterize the volume-outcome data for surgically treated sinonasal and skull base tumors and (chemo) radiation-treated nasopharyngeal malignancy.   Systematic review of the literature. Read More

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Wait and Scan Management of Intra-canalicular Vestibular Schwannomas: Analysis of Growth and Hearing Outcome.

Otol Neurotol 2022 Jul;43(6):676-684

Gruppo Otologico, Piacenza-Rome, Italy.

Objective: To report on the results of intracanalicular vestibular schwannomas (ICVS) that were managed by wait and scan and to analyze the possible predictors of tumor growth and hearing deterioration throughout the observation period.

Study Design: A retrospective case series.

Setting: Quaternary referral center for skull base pathologies. Read More

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[Giant petrosal meningioma invading the fourth ventricle: total removal of a recurrent tumor after eighteen years. Neurosurgical nuances. Case report and literature review].

Zh Vopr Neirokhir Im N N Burdenko 2022 ;86(3):77-82

Blokhin National Cancer Research Center, Moscow, Russia.

The authors present a patient and neurosurgical nuances of total resection of recurrent meningioma of posterior surface of petrous bone 65´35´30 mm. The tumor captured two critical zones of posterior cranial fossa with unusual frontal growth and spread from the surface of petrous bone to the fourth ventricle. The neoplasm filled the ventricle without lesion of ependyma. Read More

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Neoadjuvant B-RAF and MEK Inhibitor Targeted Therapy for Adult Papillary Craniopharyngiomas: A New Treatment Paradigm.

Front Endocrinol (Lausanne) 2022 9;13:882381. Epub 2022 Jun 9.

Pituitary and Skull Base Neurosurgical Department, Reference Center for Rare Pituitary Diseases HYPO, "Groupement Hospitalier Est" Hospices Civils de Lyon, "Claude Bernard" Lyon 1 University, Hôpital Pierre Wertheimer, Lyon, France.

Background: Surgical and clinical management of craniopharyngiomas is associated with high long-term morbidity especially in the case of hypothalamic involvement. Improvements in knowledge of craniopharyngioma molecular biology may offer the possibility of safe and effective medical neoadjuvant treatments in a subset of patients harboring papillary subtype tumors with a BRAFV600E mutation.

Method: We report herein two cases of tubero-infundibular and ventricular Papillary Craniopharyngiomas in which BRAF/MEK inhibitor combined therapy was used as adjuvant (Case 1) or neoadjuvant (Case 2) treatment, with a 90% reduction in tumor volume observed after only 5 months. Read More

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Clinical Problem Solving: A 56-Year-Old Woman With Right Facial Weakness, Numbness, and Diplopia.

Neurohospitalist 2022 Jul 23;12(3):512-515. Epub 2022 Feb 23.

Neurology Department, Brigham and Women's Hospital, Boston, MA, USA.

We discuss a case of a middle-aged woman with a history of urothelial carcinoma, who presented with subacute progression of double vision, right facial numbness, and back pain. Her MRI brain and spine demonstrated multifocal enhancing lesions at the skull base and throughout the spine. Since her initial serum and cerebrospinal fluid (CSF) studies were unrevealing, she underwent a biopsy of her skull base lesion, which was initially concerning for infection. Read More

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Endoscopic Transpterygoid Transcavernous Approach for Resection of a Petroclival Chondrosarcoma: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2022 Jul 20;23(1):e60-e61. Epub 2022 Apr 20.

Department of Neurosurgery, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA.

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Commentary: Microsurgical Resection of a Petroclival Meningioma via a Suboccipital Approach: Technical Nuances and Anatomical Considerations: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2022 Jul 11;23(1):e56-e57. Epub 2022 May 11.

Division of Neurosurgery, Lehigh Valley Health Network, Allentown, Pennsylvania, USA.

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Dejerine Syndrome Variant Due to Medullary Perforating Artery Ischemia During Foramen Magnum Meningioma Resection: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2022 Jul 20;23(1):e52-e53. Epub 2022 Apr 20.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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Resection of Skull Base Meningioma With Extensive Extracranial Extension: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2022 Jul 20;23(1):e51. Epub 2022 Apr 20.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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Traumatic Rupture of a Skull Base Dermoid Cyst Mimicking Chronic Meningitis.

Cureus 2022 May 17;14(5):e25066. Epub 2022 May 17.

Department of Neurology, Mount Auburn Hospital, Harvard Medical School, Boston, USA.

Cranial dermoid cysts are rare, embryologic tumors containing fat, hair, and other ectodermal elements. They occur most frequently in the posterior fossa and are typically diagnosed as incidental findings on brain imaging done for an unrelated reason. Traumatic rupture of a previously unidentified intracranial dermoid cyst can mimic symptoms of post-concussion syndrome and should be ruled out with magnetic resonance imaging (MRI). Read More

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A 2 and 5-Year Longitudinal Analysis of 671 Consecutive Patients Diagnosed with Unilateral Vestibular Schwannoma.

Otol Neurotol 2022 Jul;43(6):702-708

Department of Skull Base Surgery, Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Objective: To analyse the 2 and 5-year outcomes of a cohort of patients with newly diagnosed vestibular schwannoma patients.

Study Design: Longitudinal cohort study.

Setting: Tertiary skull base referral unit. Read More

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[Radiation therapy of malignant salivary gland tumors].

HNO 2022 Jun 10. Epub 2022 Jun 10.

Universitätsklinikum Heidelberg (UKHD) und Deutsches Krebsforschungszentrum (DKFZ), Nationales Centrum für Tumorerkrankungen (NCT), Im Neuenheimer Feld 460, 69120, Heidelberg, Deutschland.

Due to their rarity, histologic heterogeneity, and localization, treatment of malignant salivary gland tumors requires an interdisciplinary approach. First-line treatment includes complete tumor resection. Postoperative radiation therapy is advised in patients with risk factors, i. Read More

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Salvage Endoscopic Skull Base Surgery: Another Treatment Option After Immunotherapy for Recurrent Nasopharyngeal Carcinoma.

Front Immunol 2022 24;13:899932. Epub 2022 May 24.

Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China.

Background: Advanced recurrent nasopharyngeal carcinoma (NPC) is a relatively common nasopharyngeal skull base disease for which there is no uniform treatment modality. Not all patients are satisfied with the efficacy of immunotherapy with or without chemotherapy.

Methods: This study included patients who underwent salvage endoscopic skull base nasopharyngectomy after immunotherapy between February 2017 and June 2021. Read More

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Infra-Temporal and Pterygo-Palatine Fossae Tumors: A Frontier in Endoscopic Endonasal Surgery-Description of the Surgical Anatomy of the Approach and Report of Illustrative Cases.

Int J Environ Res Public Health 2022 May 25;19(11). Epub 2022 May 25.

Programma Neurochirurgia Ipofisi-Pituitary Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy.

Infratemporal and pterygopalatine fossae (ITF and PPF) represent two complex paramedian skull base areas, which can be defined as jewelry boxes, containing a large number of neurovascular and osteomuscular structures of primary importance. They are in close communication with many craniofacial areas, such as nasal/paranasal sinuses, orbit, middle cranial fossa, and oral cavities. Therefore, they can be involved by tumoral, infective or inflammatory lesions spreading from these spaces. Read More

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MRI-negative Cushing's Disease: Management Strategy and Outcomes in 15 Cases Utilizing a Pure Endoscopic Endonasal Approach.

BMC Endocr Disord 2022 Jun 9;22(1):154. Epub 2022 Jun 9.

Department of Neurological Surgery, Pauline Braathen Neurological Center, Cleveland Clinic Florida, Weston, Florida, USA.

Background: Cushing's disease (CD) is among the most common etiologies of hypercortisolism. Magnetic resonance imaging (MRI) is often utilized in the diagnosis of CD, however, up to 64% of adrenocorticotropic hormone (ACTH)-producing pituitary microadenomas are undetectable on MRI. We report 15 cases of MRI negative CD who underwent surgical resection utilizing a purely endoscopic endonasal approach. Read More

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[Malignant solitary fibrous tumors: a clinicopathological and molecular genetic analysis].

Zhonghua Bing Li Xue Za Zhi 2022 Jun;51(6):518-523

Department of Pathology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To explore the clinicopathological features, immunophenotype and molecular genetic characteristics of malignant solitary fibrous tumor (MSFT). Seven cases of MSFT were collected from the First Affiliated Hospital of Zhengzhou University from July 2018 to December 2020. Immunohistochemistry, RNA-based NGS and DNA-based NGS were performed. Read More

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[Surgical Strategy of Benign Skull Base Tumors Based on Membrane Structure].

No Shinkei Geka 2022 May;50(3):681-694

Department of Neurosurgery, The Jikei University School of Medicine.

Meningiomas, schwannomas, and pituitary adenomas are typically benign tumors of intracranial origin, but all of these tumors have a border with the surrounding tissue. The basic structure is a clear "boundary" between the tumor and its surroundings, with a thin membrane layer to create that separation. This layer of membrane is the boundary between the tumor and its surroundings and provides a space for the tumor to grow its cells, and can be viewed as the so-called "tumor capsule. Read More

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[Points and Pitfalls of Deep Dural Suture].

No Shinkei Geka 2022 May;50(3):663-670

Department of Neurosurgery, Nippon Medical School.

Infection, especially meningitis, has always been a problem in transsphenoidal surgery(TSS)for tumors of the sella turcica, and it would not be an exaggeration to say that the history of improvements in transsphenoidal sinus surgery is the history of the battle against meningitis. Furthermore, around 1990, endoscopy was introduced to TSS, and TSS has been applied to median skull base tumors extending beyond the sella turcica and is being performed as extended TSS. As a result, TSS has also been performed for surgeries with large dural defects, and the deep dural suture method(DDSM)has been advocated mainly in Japan while TSS has been improved to prevent cerebrospinal fluid leakage. Read More

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[Lateral Suboccipital Retrosigmoid and Far Lateral Approaches:Various Extensions for Schwannoma, Meningioma, and Epidermoid Cyst Surgery].

No Shinkei Geka 2022 May;50(3):625-633

Department of Neurosurgery, Tokyo Medical University.

The lateral suboccipital retrosigmoid approach is one of the most established approaches for accessing the posterior cranial fossa. In order to expand the surgical field, several extensions, including(1)extended craniotomy(e.g. Read More

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[The Anterior Transpetrosal Approach].

No Shinkei Geka 2022 May;50(3):614-624

Department of Neurosurgery, Keio University School of Medicine.

The Anterior transpetrosal approach is a skull base surgical procedure that can provide a wide operative view of the petroclival and the prepontine region. This approach requires one to accurately understand the anatomy of the anterior part of the temporal bone and the histological structure of the dura mater. In addition, it is necessary to learn operative techniques for venous preservation, accurate hemostasis at each step, and prevention of cerebrospinal fluid leakage. Read More

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[Basic Concept of Skull Base Reconstructive Surgery].

No Shinkei Geka 2022 May;50(3):586-594

Department of Plastic and Reconstructive Surgery, Graduate School of Medical and Dental Sciences(Medicine), Tokyo Medical and Dental University.

In most cases of anterior cranial fossa defects, the cranial cavity and the nasal cavity are connected, and it is necessary to reconstruct the skull base in a narrow sense to separate both cavities. If the surgical purpose is only separation, reconstruction with a pedicled local flap is often possible. As other surgical purposes such as the reconstruction of surrounding tissues are added, the transplanted tissue volume becomes insufficient, and free tissue transfer is required. Read More

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[Common Sense in Head and Neck Surgery for Malignant Skull Base Disease:Lack of Common Sense in Neurosurgery].

Takahiro Asakage

No Shinkei Geka 2022 May;50(3):578-585

Department of Head and Neck Surgery, Tokyo Medical and Dental University Hospital.

Skull base surgery for malignant skull base disease is one of the most difficult surgeries. The success of the surgery depends on the harmonization of the excellent skills of the three departments: neurosurgery, otorhinolaryngology/head and neck surgery, and plastic surgery. In addition, it is necessary to perform complete resection, that is, resection in which the malignant tumor is removed along with some surrounding healthy tissue. Read More

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[Latest Findings on Meningioma:WHO grades 1/2/3].

Soichi Oya

No Shinkei Geka 2022 May;50(3):564-571

Department of Neurosurgery, Saitama Medical Center.

While most meningiomas are histologically benign tumors, higher grade meningiomas classified as WHO grades 2 and 3 are not always amenable to the standard treatment. To accurately assess the biological characteristics and prognosis of the tumor, the WHO classification of meningiomas has been continuously revised based on the latest findings. This article describes the recent modifications of the WHO classification of meningiomas. Read More

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[Anatomy for Endoscopic Endonasal Skull Base Surgery].

No Shinkei Geka 2022 May;50(3):535-543

Department of Otolaryngology-Head and Neck Surgery, Nagoya City University, Graduate School of Medical Sciences.

Endoscopic endonasal skull base surgery has become popular due to its minimally invasive nature to the patient and the development of various medical devices. The reason why it is considered less invasive is that it is possible to reach the anterior skull base lesion using the corridor of the nasal cavity and paranasal sinuses. The roles of the nasal sinuses include acting as breathing pathways, warming, humidifying, and filtering of inhaled air, olfaction, and being a resonant cavity, all of which are important for a comfortable life, and the loss of these functions reduces the quality of life. Read More

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[History of Skull Base Surgery].

Akio Morita

No Shinkei Geka 2022 May;50(3):496-507

Department of Neurological Surgery, Nippon Medical School.

Skull base surgery is a surgical field that involves the cooperation of multiple surgical and medical specialties, including neurosurgery, head-neck surgery, plastic-reconstructive surgery, radiation oncology, as well as multiple medical supporting teams. This field has been developed with the collaborative efforts of these medical specialties, and its history can be divided into five phases: Beginning of surgery(Prior to 1940); Early skull base surgery driven by the ENT-HN surgery group(1940-70); Conventional skull base surgery development based on anatomical, physiological knowledge and microsurgical equipment and technique(1970-90); Reflection and consolidation of the surgical dimension(1995-2005); and Evolution of endoscopic and new skull base surgical techniques(2005-). Several topics and advancements have improved this surgical field, such as access to the cavernous sinus, petrosal-temporal bone, and foramen magnum; concepts of minimally invasive surgical techniques; advanced endoscopic instruments; knowledge of biological assessments; and development of surgical robotics. Read More

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Current opinions on diagnosis and treatment of adenoid cystic carcinoma.

Oral Oncol 2022 Jul 2;130:105945. Epub 2022 Jun 2.

Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, Hunan 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Anatomy Laboratory of Division of Nose and Cranial Base, Clinical Anatomy Center of Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. Electronic address:

Adenoid cystic carcinoma (ACC) is a rare malignant tumor derived mainly from the salivary glands, representing approximately 1% of all headandneck carcinomasand 10% of all salivary gland neoplasms. ACC displays a paradoxical behavioral combination of an indolent growth pattern but an aggressive progression, with local recurrence and distant metastasis. The propensity of ACC of the head and neck (ACCHN) for perineural invasion and its anatomical location, especially if it extends to the nasal cavity and paranasal sinuses, facilitates tumor involvement in the surrounding structures, such as the orbit, pterygopalatine fossa, Meckel'scave, and cavernous sinus, which can lead to skull base involvement and intracranial extension. Read More

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Primary Intraosseous Cavernous Hemangioma of the Cranium: A Systematic Review of the Literature.

World Neurosurg 2022 May 30;164:323-329. Epub 2022 May 30.

Department of Neurosurgery, "Attikon" University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Primary intraosseous cavernous hemangioma (PICH) is a rare, benign tumor of vascular origin, typically arising in the vertebral body. Its presence in the skull is exceedingly rare, with only a few cases being reported worldwide. We carried out the first systematic review of the literature, covering the epidemiology, clinical and imaging features, management, and prognosis of cranial PICH. Read More

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Surgical Experience of Transcranial Approaches to Large-to-Giant Pituitary Adenomas in Knosp Grade 4.

Front Endocrinol (Lausanne) 2022 12;13:857314. Epub 2022 May 12.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Pituitary adenomas in Knosp grade 4 are difficult to resect completely and are generally involved in poor prognosis, because of the close relationship between the tumor and internal carotid. In this study, the authors retrospectively reviewed the outcome of different transcranial approaches in the management of large-to-giant pituitary adenomas in Knosp grade 4. A total of 42 patients with large-to-giant pituitary adenomas in Knosp grade 4, who underwent craniotomy in the Pituitary Disease Subdivision, Department of Neurosurgery, Beijing Tiantan Hospital, between March 2012 and March 2015 were included in this study. Read More

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