12,374 results match your criteria Skull Base Benign Tumors

Preservation of nasal turbinates in endoscopic, anterior skull base surgery-yes, we can!

Eur Arch Otorhinolaryngol 2021 May 8. Epub 2021 May 8.

Department of Neurosurgery, Medical University of Graz, Graz, Austria.

Objective: To evaluate the frequency, type and indications of nasal turbinate (NT) resection during endoscopic, anterior skull base surgery and to analyze factors that may have an impact on the need of NT removal.

Methods: In this retrospective cohort study, 306 subjects (150 males and 156 females, mean age 55.4 ± 15. Read More

View Article and Full-Text PDF

Sinonasal Renal Cell-Like Adenocarcinoma.

Cureus 2021 Apr 4;13(4):e14285. Epub 2021 Apr 4.

Otolaryngology - Head and Neck Surgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, USA.

Sinonasal renal cell-like adenocarcinoma (SNRCLA) is a newly defined, rare malignant tumor of the nasal cavity. The clinical course and response to treatment remain uncertain. The purpose of this study is to report a new case of SNRCLA and review the literature to determine clinical characteristics, treatment options, and outcomes. Read More

View Article and Full-Text PDF

Free flap transfer, a safe and efficient method for reconstruction of composite skull base defects after salvage resection of advanced intra- and extracranial communicating tumors: Short title Free flap transfer for reconstruction of composite skull base defects.

World Neurosurg 2021 Apr 30. Epub 2021 Apr 30.

Department of Neurosurgery, National Cancer Center/ National Clinical Research Center for Cancer/ Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100021, China. Electronic address:

Object: Surgical treatment of advanced intra- and extracranial communicating skull base tumors is challenging, especially for the reconstruction of the large composite defect left by tumor resection. The aim of the study is to evaluate the utility of the free flap reconstruction of the defects resulting from radical resection of these tumors in a single institution.

Methods: The clinical data of 17 consecutive patients who underwent free flap reconstruction for defect left by salvage resection of advanced intra- and extracranial communicating tumors from 2013 to 2019 were retrospectively collected and analyzed. Read More

View Article and Full-Text PDF

Brain-invasive meningiomas: molecular mechanisms and potential therapeutic options.

Brain Tumor Pathol 2021 Apr 26. Epub 2021 Apr 26.

Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, People's Republic of China.

Meningiomas are the most commonly diagnosed benign intracranial adult tumors. Subsets of meningiomas that present with extensive invasion into surrounding brain areas have high recurrence rates, resulting in difficulties for complete resection, substantially increased mortality of patients, and are therapeutically challenging for neurosurgeons. Exciting new data have provided insights into the understanding of the molecular machinery of invasion. Read More

View Article and Full-Text PDF

Lateral skull base surgery for posterior oral cavity cancer.

Int J Oral Maxillofac Surg 2021 Apr 19. Epub 2021 Apr 19.

Department of Oral and Maxillofacial Surgery, Second Xiangya Hospital of Central South University, Changsha, Hunan, China. Electronic address:

The aim of this study was to better understand posterior oral cavity cancer (POCC) and its surgical treatment. This was a retrospective study of 76 patients who were diagnosed with POCC and underwent surgical treatment. Twenty-eight patients were treated with anatomical unit resection surgery (AURS) and 48 patients with conventional surgery. Read More

View Article and Full-Text PDF

Aggressive Progression of a WHO Grade I Meningioma of the Posterior Clinoid Process: An Illustration of the Risks Associated With Observation of Skull Base Meningiomas.

Cureus 2021 Mar 19;13(3):e14005. Epub 2021 Mar 19.

Nerosurgery, Prince of Wales Private Hospital, Sydney, AUS.

Benign, small, and asymptomatic World Health Organization grade I meningiomas are usually managed expectantly with surveillance imaging with the assumption that they are predictably slowing growing. In this paper, we report the case of an incidentally discovered small, right-sided posterior clinoid meningioma in a 53-year-old female. The tumor was managed conservatively but an annual surveillance magnetic resonance imaging demonstrated that the meningioma had an unexpected significant growth impinging on the brainstem, requiring surgical resection and radiosurgery for residual tumor. Read More

View Article and Full-Text PDF

Invisible compression, anterior fossa tumor causing trigeminal neuralgia.

Surg Neurol Int 2021 17;12:106. Epub 2021 Mar 17.

Department of Neurosurgery, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain.

Background: Trigeminal neuralgia secondary to posterior and middle fossae tumors, whether ipsilateral or contralateral, has been well described. However, this disabling disease has never been reported in the context of anterior fossa neoplasms.

Case Description: A 75-year-old female with right hemifacial pain was diagnosed with an anterior clinoid meningioma. Read More

View Article and Full-Text PDF

Hemorrhagic Giant Cell Tumor of the Occipital Skull Base: A Case Report and Literature Review.

Cureus 2021 Mar 11;13(3):e13832. Epub 2021 Mar 11.

Department of Pediatric Surgery, Division of Pediatric Neurosurgery, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, USA.

Giant cell tumor of bone is a benign but locally aggressive osteolytic neoplasm that represents 3% to 5% of all primary bone tumors, primarily found at the epiphyses of long bones. Less than 1% are of calvarial origin. Herein, we report a rare case of a nine-year-old girl with a hemorrhagic giant cell tumor of the left occipital skull base. Read More

View Article and Full-Text PDF

Petrosal Approach With Preservation of the Superior Petrosal Sinus (the Graceful Petrosal) for Resection of Giant Trigeminal Schwannoma: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 Apr;20(5):E342-E343

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Trigeminal schwannomas are benign tumors amendable to curative surgical resection.1 Excellent outcomes, with preservation and improvement of cranial nerve function, including trigeminal nerve function, have been reported with microsurgical resection through skull base approaches.2 Dumbell shaped tumors, involving the middle and posterior fossa, are more challenging. Read More

View Article and Full-Text PDF

Comparison of ependymomas and medulloblastomas located in the posterior cranial fossa: An anatomical and histopathological study.

Arch Ital Biol 2020 12;158(3-4):74-81

Department of Neurosurgery, Faculty of Medicine, University of Dicle, 21280, Diyarbakır, Turkey - Email:

Posterior fossa tumors (PFTs) include medulloblastomas, atypical teratoid/rhabdoid tumors, pilocytic astrocytomas, ependymomas, and brainstem gliomas. We evaluated patients with surgery at our clinic, comparing epidemiological, clinical, radiological, and pathological characteristics of medulloblastoma and ependymoma to identify factors that might assist preoperative diagnosis, help to develop treatment algorithms, and have prognostic value after surgery. Pediatric patients from 0 to 16 and young adults from 16 to 29 years of age with surgery for pathologically confirmed ependymomas or medulloblastomas between January 2014 and January 2020 were eligible. Read More

View Article and Full-Text PDF
December 2020

Post-operative outcomes of different surgical approaches to oropharyngeal squamous cell cancer: a case-matched study.

J Laryngol Otol 2021 Apr 5;135(4):348-354. Epub 2021 Apr 5.

ENT Clinic, Head and Neck Department, University of Trieste, Italy.

Objective: To compare the post-operative outcomes of transoral laser microsurgery, lateral pharyngotomy and transmandibular surgery in oropharyngeal cancer management.

Methods: Records of 162 patients treated with transmandibular surgery, transoral laser microsurgery or lateral pharyngotomy were reviewed. The transoral laser microsurgery cohort was matched with the lateral pharyngotomy and transmandibular surgery cohorts for tumour stage, tumour subsite and human papilloma virus status, and the intra- and post-operative outcomes were compared. Read More

View Article and Full-Text PDF

Surgical Outcome of Trigeminal Schwannomas.

Cancers (Basel) 2021 Mar 15;13(6). Epub 2021 Mar 15.

Department of Neurosurgery, Klinikum rechts der Isar, School of Medicine, Technical University Munich, 81675 Munich, Germany.

(1) Background: As resection of trigeminal schwannomas is challenging, due to anatomical involvement of the anterior, middle and posterior fossa, the appropriate approach is important. We report our experience with surgical resection of trigeminal schwannomas by simple and classic skull-base approaches. (2) Methods: We performed a retrospective single-center study including patients who underwent surgery for trigeminal schwannoma tumors between June 2007 and May 2020, concentrating on surgical technique, extent of resection, postoperative outcome and complications. Read More

View Article and Full-Text PDF

Not all anosmia and fever was COVID-19 infection: a case report.

Pan Afr Med J 2020 23;37:371. Epub 2020 Dec 23.

Neurosurgery Department, Mohamed V Military Training Hospital, Rabat, Morocco.

COVID-19 pandemic touch all part of world to the date more than fifteen millions of patients are infected by virus including about 1,388,926 deaths (European Centre for Disease Prevention and Control an agency of the European Union). Morocco has put in place strict containment measures to control the disease and prevent the saturation of health systems. One of the great difficulties is to quickly identify asymptomatic and paucisymptomatic cases which function as an important vector of contagion. Read More

View Article and Full-Text PDF

[Analysis of efficacy of coblation assisted endoscope system for the treatment of parapharyngeal space tumors with transoral approach].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Mar;35(3):204-208

Department of Otorhinolaryngology,the First Affiliated Hospital,Nanjing Medical University,Nanjing,210029,China.

To summarize and analyze the feasibility, safety and efficacy of parapharyngeal space surgery assisted by coblation and endoscopic system with transoral approach. The data of 20 patients with parapharyngeal space tumors were retrospectively analyzed. All the patients underwent CT and/or MRI examination before surgery, and all underwent transoral approach assisted by coblation and endoscopic systems. Read More

View Article and Full-Text PDF

New proposal to revise the classification for squamous cell carcinoma of the external auditory canal and middle ear.

J Laryngol Otol 2021 Apr 31;135(4):297-303. Epub 2021 Mar 31.

Department of Otolaryngology - Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: The prognosis of patients with advanced squamous cell carcinoma of the external auditory canal and middle ear has been improved by advances in skull base surgery and multidrug chemoradiotherapy during the last two decades.

Methods: Ninety-five patients with squamous cell carcinoma of the external auditory canal and middle ear who were treated between 1998 and 2017 were enrolled. The number of patients with tumour stages T1, T2, T3 and T4 was 15, 22, 24 and 34, respectively. Read More

View Article and Full-Text PDF

Use of Salvage Surgery or Stereotactic Radiosurgery for Multiply Recurrent Skull Base Chordomas: A Single-Institution Experience and Review of the Literature.

J Neurol Surg B Skull Base 2021 Apr 14;82(2):161-174. Epub 2020 Jan 14.

Department of Radiation Oncology, University of Southern California, Keck School of Medicine, Los Angeles, California, United States.

 Chordomas are locally destructive neoplasms characterized by appreciable recurrence rates after initial multimodality treatment. We examined the outcome of salvage treatment in recurrent/progressive skull base chordomas.  This is a retrospective review of recurrent/progressive skull base chordomas at a tertiary urban academic medical center. Read More

View Article and Full-Text PDF

Clinical Assessment and Lesion-Specific Management of Orbital Vascular Malformations.

J Neurol Surg B Skull Base 2021 Feb 23;82(1):116-128. Epub 2021 Mar 23.

Division of Orbital and Ophthalmic Plastic Surgery, Doheny and Stein Eye Institutes, University of California, Los Angeles, United States.

The systematic classification of vascular disease as proposed and refined by the International Society for the Study of Vascular Anomalies (ISSVA) divides vascular pathology first into tumors and malformations. Malformations are described as simple and complex, where simple malformations contain a single vascular system and complex malformations comprised of multiple vascular systems. Arteriovenous malformations are considered in terms of inflow characteristics which are primarily responsible for the key management challenges. Read More

View Article and Full-Text PDF
February 2021

Masses of the Lacrimal Gland: Evaluation and Treatment.

J Neurol Surg B Skull Base 2021 Feb 18;82(1):100-106. Epub 2021 Feb 18.

Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, United States.

Lacrimal gland lesions account for approximately 9 to 10% of all biopsied orbital masses. Potential causes include nongranulomatous and granulomatous inflammation, autoimmune disease, lymphoproliferative disorders, benign epithelial proliferation, malignant neoplasia, and metastatic disease. Inflammatory lesions and lymphoproliferative disorders are the most common and may be unilateral or bilateral; they may also be localized to the orbit or associated with systemic disease. Read More

View Article and Full-Text PDF
February 2021

Optic Nerve Gliomas.

J Neurol Surg B Skull Base 2021 Feb 19;82(1):91-95. Epub 2021 Jan 19.

Division of Hematology/Oncology, Department of Pediatrics, Albany Medical College, Slingerlands, New York, United States.

 To describe the diagnostic and management features of optic nerve gliomas.  Literature review.  Optic nerve gliomas are generally benign in the pediatric age group although they are usually malignant and aggressive in adults. Read More

View Article and Full-Text PDF
February 2021

"Single-step" resection and cranio-orbital reconstruction for spheno-orbital metastasis with custom made implant. A case report and review of the literature.

Int J Surg Case Rep 2021 Apr 11;81:105755. Epub 2021 Mar 11.

Department of Neurosurgery, Hospital "M. Bufalini" - AUSL della Romagna, 286 Viale Ghirotti, 47521 Cesena, Italy.

Introduction And Importance: Brain metastasis involving the skull base is a rare complication of malignant tumors. Besides radiotherapy, surgical treatment is a therapeutical option even though it may apply complex technical procedures that may delay complementary therapies. However, in recent days, the innovation of custom-made implants allows treating selected patients with fewer complications and better results. Read More

View Article and Full-Text PDF

Non-Coding RNAs Participate in the Pathogenesis of Neuroblastoma.

Front Oncol 2021 24;11:617362. Epub 2021 Feb 24.

Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Neuroblastoma is one of the utmost frequent neoplasms during the first year of life. This pediatric cancer is believed to be originated during the embryonic life from the neural crest cells. Previous studies have detected several types of chromosomal aberrations in this tumor. Read More

View Article and Full-Text PDF
February 2021

A Rare Tumor of Clivus Masquerading as Pituitary Adenoma.

Asian J Neurosurg 2020 Oct-Dec;15(4):1091-1095. Epub 2020 Dec 21.

Department of Pathology, ICMR-National Institute of Pathology, New Delhi, India.

Giant cell tumors (GCT) are generally benign, commonly affecting young adults, with a slight preponderance in females. They are locally aggressive with a high rate of local recurrence. Most of them are found in the epiphysis of long bones, making the base of the skull a rare site. Read More

View Article and Full-Text PDF
December 2020

Extended Anterolateral Infralabyrinthine Transjugular Approach for Microsurgical Resection of Giant Glomus Vagale Tumor: Operative Video and Technical Nuances.

J Neurol Surg B Skull Base 2021 Feb 26;82(Suppl 1):S59-S60. Epub 2020 Nov 26.

Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Neurological Institute of New Jersey, Saint Barnabas Medical Center, RWJ Barnabas Health, Newark, New Jersey, United States.

Glomus vagale tumor is a paraganglioma of the vagus nerve. It is a rare type of benign tumor that occupies the head and neck and skull base regions. Patients often present with lower cranial nerve dysfunctions such as difficulty swallowing, tongue weakness, and hoarseness. Read More

View Article and Full-Text PDF
February 2021

Image-based diagnosis of residual or recurrent nasopharyngeal carcinoma may be a phantom tumor phenomenon.

Medicine (Baltimore) 2021 Feb;100(8):e24555

Department of Nuclear Medicine, Tri-Service General Hospital National Defense Medical Center.

Abstract: Some nasopharyngeal carcinoma (NPC) patients may present convincing radiological evidence mimicking residual or recurrent tumor after radiotherapy. However, by means of biopsies and long term follow-up, the radiologically diagnosed residuals/recurrences are not always what they appear to be. We report our experience on this "phantom tumor" phenomenon. Read More

View Article and Full-Text PDF
February 2021

FDG PET/CT to Detect Incidental Findings in Patients With Hepatocellular Carcinoma-Additional Benefit for Patients Considered for Liver Transplantation?

Clin Nucl Med 2021 Mar 4. Epub 2021 Mar 4.

From the Clinic of Nuclear Medicine Clinic of General, Visceral and Vascular Surgery, Jena University Hospital, Jena, Germany.

Purpose: FDG PET/CT has been described for noninvasive grading, detection of extrahepatic spread, and recurrence in hepatocellular carcinoma (HCC). As compared with localized imaging approaches (MRI, ultrasonography), FDG PET/CT not only focuses on the liver, but covers a long field of view from the base of the skull to the thighs, visualizing pathologic findings not related to HCC. The aims of this retrospective study were to (1) describe the frequency of relevant incidental findings on FDG PET/CT in HCC patients, (2) evaluate the impact on treatment strategy in HCC patients considered for liver transplantation, and (3) to discuss the role of FDG PET/CT in patients considered for transplantation in general. Read More

View Article and Full-Text PDF

Pneumatosis intestinalis in a radioactive iodine-refractory metastasic thyroid papillary carcinoma with BRAF mutation treated with dabrafenib-trametinib: a case report.

J Med Case Rep 2021 Mar 2;15(1):109. Epub 2021 Mar 2.

Medical Oncology Department, University Hospital 12 de Octubre, Madrid, Spain.

Background: Pneumatosis intestinalis (PI) is a rare entity which refers to the presence of gas within the wall of the small bowel or colon which is a radiographic sign. The etiology and clinical presentation are variable. Patients with PI may present either with chronic mild non-specific symptoms or with acute abdominal pain with peritonitis. Read More

View Article and Full-Text PDF

Locally advanced tongue squamous cell carcinoma in epidermolysis simplex bullosa patient: a therapeutic conundrum.

Ann R Coll Surg Engl 2021 Mar;103(3):e85-e87

Head and Neck & Skull Base Centre, King Abdullah Medical City, Mecca, Saudi Arabia.

Epidermolysis bullosa simplex (EBS) is a debilitating condition affecting the skin and mucous membranes that is characterised by frequent ulceration and blistering on trivial trauma. In EBS, oral cavity mucosal injuries lead to a high propensity for developing squamous cell carcinomas. Locally advanced tongue carcinoma arising in this background presents a challenging therapeutic conundrum. Read More

View Article and Full-Text PDF

Skull Base Chordoma: A Case Presentation and Review of Literature.

West Afr J Med 2021 Feb;38(2):171-175

Department of Surgery, University of Benin/University of Benin Teaching Hospital, Benin City, Edo State,Nigeria.

Chordomas are rare, aggressive, bone cancers with notochordal differentiation, a marked predilection for the axial skeleton, and higher incidence in males. Approximately 30% of chordomas occur at the skull base where they make up 0.1-0. Read More

View Article and Full-Text PDF
February 2021

Strategies for Optic Pathways Decompression for Extra-Axial Tumors or Intracranial Aneurysms: A Technical Note.

J Neurol Surg A Cent Eur Neurosurg 2021 Feb 28. Epub 2021 Feb 28.

Department of Neurosurgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.

Background:  Different types of skull base tumors and intracranial aneurysms may lead to compression of the optic pathways. Since most of them are biologically benign conditions, the first aim of surgery is preservation of optic nerves rather than the oncologic radicality.

Materials And Methods:  Based on the progressive technical refinements coming from our institutional experience of optic nerve compression from aneurysms and extra-axial tumors, we analyzed the surgical steps to release nerves and chiasm during tumor debulking and aneurysm clipping. Read More

View Article and Full-Text PDF
February 2021