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Am J Dermatopathol 2022 Mar;44(3):170-173

Department of Pathology, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA.

Background: Rhabdomyomatous mesenchymal hamartomas (RMHs), also termed striated muscle hamartomas, are rare benign tumors of skin and subcutis, which mostly occur at birth with a predilection for the head and neck. Simple surgical excision is the treatment modality of choice with excellent prognosis.

Objective: To review the spectrum of the different clinical and pathologic features of RMHs in pediatric patients and recognize their characteristics to avoid confusion with other lesions in their list of differential diagnosis. Read More

Am J Dermatopathol 2020 Nov;42(11):858-860

Departments of Pathology, and.

Epidermotropic metastasis of head and neck squamous cell carcinoma is rare. We report a case of a 56-year-old white man with a history of oral squamous cell carcinoma who presented with multiple papules on the face, eyelid, and chest wall. The histopathologic examination of the skin lesions revealed nests of malignant cells with basaloid features and zones of cytoplasmic vacuolization predominantly within the dermis but focally involving the epidermis. Read More

Int J Dermatol 2020 May 6;59(5):582-589. Epub 2020 Mar 6.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: Primary cutaneous angiosarcoma (CA) is a rare but aggressive tumor with a high rate of local recurrence. This study was designed to analyze the clinicopathological features of primary CA and identify factors of cutaneous manifestations associated with the prognosis of angiosarcoma.

Methods: Medical records of 55 patients with primary CA were retrospectively analyzed to investigate clinical features, survivals, and prognostic factors. Read More

Pediatr Dermatol 2018 Nov 15;35(6):808-816. Epub 2018 Oct 15.

Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.

Background: Recent reports indicate that tufted angioma is a rare vascular neoplasm that manifests more frequently at birth than previously thought. Few studies specifically address congenital presentation.

Objectives: We analyzed the clinicopathological characteristics, clinical course, and treatment of congenital tufted angioma (cTA) and evaluated variables that were indicative of problematic lesions. Read More

Ann Pathol 2018 Dec 16;38(6):386-390. Epub 2018 Aug 16.

Service de pathologie, centre hospitalier Montbéliard, 12, rue Docteur Flamand, 25200 Montbéliard, France.

We report the case of a Caucasian 73-year-old woman, without medical history, who is operated of two lesions of the forehead and the scalp measuring 0.4 and 1cm. There is no adenopathy. Read More

J Neurosurg 2018 06 4;128(6):1725-1730. Epub 2017 Aug 4.

Departments of1Neurosurgery and.

Intracranial intravascular papillary endothelial hyperplasia (IPEH), also referred to as Masson's tumor, is a condition that rarely occurs in the nervous system. IPEH most frequently occurs extracranially in the skin of the face, skull, neck, and trunk and can easily be mistaken clinically, radiologically, and histologically for angiosarcoma, organizing hematoma, or other vascular malformations. IPEH accounts for roughly 2% of all vascular tumors and is extremely rare intracranially, with only 23 reported cases compared with more than 300 cases of IPEH occurring in the skin and subcutaneous tissue. Read More

An Bras Dermatol 2017 Mar-Apr;92(2):235-238

Universidade Federal do Espírito Santo (Ufes) - Vitória (ES), Brazil.

Angiosarcoma is a rare and aggressive tumor with high rates of metastasis and relapse. It shows a particular predilection for the skin and superficial soft tissues. We report three distinct and typical cases of angiosarcoma that were diagnosed in a single dermatology clinic over the course of less than a year: i) Angiosarcoma in lower limb affected by chronic lymphedema, featuring Stewart-Treves syndrome; ii) a case of the most common type of angiosarcoma loated in the scalp and face of elderly man and; iii) a skin Angiosarcoma in previously irradiated breast. Read More

Am J Rhinol Allergy 2016 May;30(3):83-90

Otorhinolaryngology and Head and Neck Surgery Clinic, Bakirkoy Dr Sadi Konuk Research and Training Hospital, Istanbul, Turkey.

Objectives: The goal of this study was to review the main lesion types of the nasal skin and appropriate treatment strategies rather than to present a comprehensive list of all diseases that affect the skin that can involve the nose.

Methods: We reviewed the main nasal skin lesion types and available treatment strategies. Nasal skin lesions were classified as benign, premalignant, or malignant. Read More

An Bras Dermatol 2015 Jul-Aug;90(4):488-93

Medical University of Graz, Graz, AT.

Background: The dermoscopic criteria of extrafacial melanomas are well-known.

Objective: To determine the frequency of dermatoscopic findings in head and neck melanomas (HNM) and to assess the distinguishing dermoscopic criteria of facial and extrafacial melanoma.

Methods: This observational study included 108 patients with HNM (63% male, mean age 64 years). Read More

JAMA Otolaryngol Head Neck Surg 2015 Apr;141(4):335-40

Department of Radiation Oncology, Mayo Clinic, Scottsdale, Arizona.

Importance: The etiology and optimal treatment are unknown for angiosarcoma, an aggressive malignant tumor that affects vascular endothelial cells and can be mistaken for benign lesions such as hemangioma.

Objective: To determine the treatment outcomes of patients with angiosarcoma of the face or scalp treated with a combination of surgery, radiation therapy, and/or chemotherapy.

Design, Setting, And Participants: Retrospective study of 55 patients with angiosarcoma of the face or scalp treated between January 1, 1973, and December 31, 2012, at a tertiary-care academic medical institution. Read More

World J Gastroenterol 2014 Dec;20(45):17254-9

Xue-Li Jin, Xi-Bin Xiao, Lian-Sheng Huang, Xiao-Ying Zhao, Department of Hematology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China.

Blue rubber bleb nevus syndrome (BRBNS) is a rare disease characterized by multiple venous malformations and hemangiomas in the skin and visceral organs. The lesions often involve the cutaneous and gastrointestinal systems. Other organs can also be involved, such as the central nervous system, liver, and muscles. Read More

Ann Dermatol 2014 Apr 30;26(2):231-5. Epub 2014 Apr 30.

Department of Dermatology, School of Medicine, The Catholic University of Korea, Seoul, Korea.

Angiosarcoma is a highly malignant vascular tumor of endothelial origin. Initially, a cutaneous manifestation presents as a singular or multifocal bruise-like patches on the skin, most frequently on the face, the scalp or the neck regions. On progression, the lesions become violaceous, and ill-defined spongy nodular tumors appear. Read More

J Craniomaxillofac Surg 2014 Oct 1;42(7):e353-8. Epub 2014 Apr 1.

Department of Maxillofacial Surgery, University of Naples "Federico II", Naples, Italy.

This is a literature review and retrospective chart review of ten years experience on the treatment of midcheek masses in our department. The purpose of this study is to provide the reader with an overview of the pathology of this complex anatomic area focusing the attention on the differential diagnosis and the recent surgical strategies. From May 2002 to December 2012 we enrolled 22 consecutive patients studied for masses located in the midcheek area. Read More

JAMA Dermatol 2014 May;150(5):546-9

Division of Dermatology, Washington University in St Louis School of Medicine, St Louis, Missouri.

Importance: Pseudoaneurysm is a well-known complication of trauma and iatrogenic injury to the vasculature. We report 3 cases of postsurgical pseudoaneurysm after Mohs surgery.

Observations: Three patients who underwent Mohs surgery for nonmelanoma skin cancers presented between 2 and 4 weeks after surgery with several days' history of painful, enlarging, pulsatile subcutaneous masses. Read More

Lasers Surg Med 2014 Mar 6;46(3):173-9. Epub 2014 Jan 6.

Department of Dermatology, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou Children's Hospital, Wenzhou, 325027, Zhejiang Province, China.

Background And Objective: There is an increasing interest in treating vascular lesions with a long-pulse Alexandrite laser. However, it is difficult to search information in the literature about infantile hemangiomas (IH) treated with long-pulse Alexandrite laser. This article aims to determine whether 755 nm long-pulse Alexandrite laser is effective and safe for early intervention of IH and provides some new data on this issue. Read More

Iran J Pediatr 2011 Sep;21(3):350-6

Pediatric Surgery Unit, Department of Surgery, University of Benin Teaching Hospital, Benin City, Nigeria.

Objective: Treatment of hemangioma/vascular tumors emphasize minimal invasion which require sophisticated facilities. This study reports the role of surgery in the management of symptomatic, and hemangioma which failed to respond to other modalities of treatment in resource-limited subregion.

Methods: A six-year (2004-2009) prospective study on the challenges and outcome of children referred for surgical management of hemangioma/vascular tumors was undertaken at the University of Benin Teaching Hospital, Nigeria. Read More

J Cutan Pathol 2012 May 5;39(5):493-9. Epub 2012 Apr 5.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030-4009, USA.

Background: Trichilemmoma (TL) can occur as a solitary sporadic lesion usually on the face or as multiple facial lesions almost invariably associated with Cowden syndrome (CS). CS is a multisystem disorder caused by a germline inactivating mutation in PTEN (10q23.31), a tumor suppressor gene. Read More

J Oral Maxillofac Surg 2010 Oct 3;68(10):2422-30. Epub 2010 Jul 3.

Department of Oral and Maxillofacial Surgery, Second Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Purpose: This clinical study assessed a pedicled supraclavicular fasciocutaneous island flap (SFIF) based on the transverse cervical artery that was extended to include shoulder skin for reconstructing the head and neck.

Patients And Methods: Pedicled SFIFs extended to include the shoulder skin based on the cutaneous feeder vessels and perforator vessels in the deep fascia of the transverse cervical artery were designed for 24 patients with defects of the head and neck after cancer ablation. Preoperative 3-dimensional computed tomographic angiography was performed in all patients. Read More

J Cutan Pathol 2010 Aug 8;37(8):901-6. Epub 2010 Feb 8.

Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Cutaneous angiosarcoma can sometimes mimic other benign and malignant lesions, thereby presenting a difficult differential diagnosis. In the two cases of cutaneous angiosarcoma presented herein, extensive foamy cell alteration of tumor cells resembled a reactive xanthogranulomatous process. Foamy cell angiosarcoma is an unusual and deceptively benign morphologic variant of cutaneous angiosarcoma. Read More

Dermatol Online J 2008 Sep 15;14(9):17. Epub 2008 Sep 15.

There are 4 types of plasma-cell neoplasia: classic multiple myeloma (MM), extramedullary plasmacytoma without MM, solitary plasmacytoma of bone, and plasma-cell leukemia. Cutaneous involvement may be seen in all 4 types of plasma-cell neoplasia. Specific cutaneous involvement in patients with MM is very uncommon. Read More

Surv Ophthalmol 2007 Sep-Oct;52(5):523-8

Baylor College of Medicine, Department of Ophthalmology, Houston, Texas, USA.

An 83-year-old man was seen with a history of bilateral progressive loss of vision of 1 month's duration. On examination, there was a reddish, nodular lesion adjacent to the right side of the nose. Slit-lamp examination revealed a reddish iris mass in the left eye. Read More

Arch Dermatol 2007 Jan;143(1):75-7

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Background: Cutaneous angiosarcoma is a rare, life-threatening tumor that is often initially misdiagnosed. This delay in diagnosis can affect tumor growth, metastatic potential, and prognosis.

Observations: We describe the "head-tilt maneuver," which highlights the vascular nature of these lesions and can be of potential benefit in early recognition and better appreciation of the clinical extent of this tumor. Read More

An Pediatr (Barc) 2003 Apr;58(4):339-49

Servicio de Neurología Pediátrica. Hospital Universitario La Paz. Madrid. Spain.

Objective: Cutaneous hemangiomas and vascular malformations constitute a systemic disease that is the most frequent of the neurocutaneous syndromes reported to date. It appears more frequently in women than in men. The aim of this study was to describe the characteristics of this new neurocutaneous syndrome. Read More

Zhonghua Kou Qiang Yi Xue Za Zhi 2002 Nov;37(6):418-20

Department of Head and Neck Surgery, Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China.

Objective: To evaluate the clinical effect of submental island flap.

Methods: The influence of head and neck radiotherapy and neck lymph node metastasis on the flap was analysed. The clinical effect in the near future and longterm of submental island flap for defects repair was evaluated. Read More

Am J Dermatopathol 2001 Apr;23(2):149-53

Institute of Pathology, Nuremburg, Germany.

The autosomal dominant Birt-Hogg-Dubé syndrome is a cutaneo-intestinal condition that manifests on the skin in the form of multiple, skin-colored small papules that, histologically, prove to be mantleomas (fibrofolliculomas and trichodiscomas). These cutaneous lesions usually appear in the region of the head, neck, and upper part of the trunk. To date, only a single report in the literature describes the localized occurrence of this syndrome. Read More

Laryngorhinootologie 1999 Oct;78(10):557-60

Klinik und Poliklinik für Hals-, Nasen- und Ohrenkranke, Ludwig Maximilians-Universität München.

Introduction: Angiosarcomas are rare, aggressive tumors of vascular origin, most commonly affecting older males. An optimum treatment strategy has not yet been defined.

Case Report: We report on a 68-year-old male patient who initially presented with a small, bruise-like macule of the cheek. Read More

Dermatol Surg 1996 Oct;22(10):841-4

Department of Dermatologic Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, USA.

Background And Design: The frequency-doubled Q-switched, neodymium:yttrium-aluminum-garnet (FD QSNd:YAG) laser has proven to be safe and effective in treating cutaneous pigmented lesions and tattoos. The observance of purpura following FD QSNd:YAG laser treatment of epidermal pigmented lesions led us to evaluate the use of this laser in the treatment of vascular lesions. The treatment protocol was designed to assess the efficacy of the FD QSNd:YAG laser in the treatment of small cutaneous vascular lesions such as telangiectases and small angiomas. Read More

Otolaryngol Head Neck Surg 1995 Nov;113(5):564-8

Department of Otolaryngology, McGill University, Royal Victoria Hospital, Montreal, Quebec.

Method: The bilateral transverse cervical arteries of 16 fresh cadavers were exposed by an infraclavicular midline approach. Each artery was cannulated, and methylene blue dye was infused to delineate the skin territory subserved by the vessel. The two major infusion skin patterns obtained allowed fashioning of a thin fasciocutaneous flap incorporating supraclavicular skin, which was based on the transverse cervical artery; or a larger flap additionally incorporating upper back skin and varying amounts of trapezius muscle, when the artery had a dorsal scapular artery branch. Read More