3,259 results match your criteria Skin Tissue Expansion


Distinct interactors define the p63 transcriptional signature in epithelial development or cancer.

Biochem J 2022 Jun;479(12):1375-1392

Department of Experimental Medicine, TOR, University of Rome 'Tor Vergata', Rome, Italy.

The TP63 is an indispensable transcription factor for development and homeostasis of epithelia and its derived glandular tissue. It is also involved in female germline cell quality control, muscle and thymus development. It is expressed as multiple isoforms transcribed by two independent promoters, in addition to alternative splicing occurring at the mRNA 3'-UTR. Read More

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ECOG-ACRIN Guideline for Contouring and Treatment of Early Stage Anal Cancer Using IMRT/IGRT.

Pract Radiat Oncol 2022 Jul-Aug;12(4):335-347

Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, Ohio. Electronic address:

Purpose: Previous anal cancer guidelines delineate target volumes similarly for all patients with squamous cell carcinoma of the anal canal and/or perianal skin (SCCA), regardless of disease stage. The purpose of this guideline is to provide customized radiation treatment recommendations for early stage (T1-2 N0 M0) anal cancer treated with intensity modulated and image guided radiation therapy (RT).

Methods And Materials: A contouring atlas and radiation treatment recommendations for the ongoing, randomized phase II trial of deintensified chemoradiation for early stage SCCA (EA2182) was created by an expert panel of radiation oncologists. Read More

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Single-Cell Transcriptomics Uncover Key Regulators of Skin Regeneration in Human Long-Term Mechanical Stretch-Mediated Expansion Therapy.

Front Cell Dev Biol 2022 30;10:865983. Epub 2022 May 30.

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Tissue expansion is a commonly performed therapy to grow extra skin for reconstruction. While mechanical stretch-induced epidermal changes have been extensively studied in rodents and cell culture, little is known about the mechanobiology of the human epidermis . Here, we employed single-cell RNA sequencing to interrogate the changes in the human epidermis during long-term tissue expansion therapy in clinical settings. Read More

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Reconstruction of Scalp Anterior Hairline with Tissue Expansion and Skin Flap.

Skin Appendage Disord 2022 May 6;8(3):261-264. Epub 2021 Dec 6.

Coordinator of Plastic Surgery Department, Hospital do Servidor Público Municipal, São Paulo, Brazil.

Introduction: Cutaneous defects involving the frontal region and anterior hairline of the scalp can result from congenital or acquired conditions. The negative esthetic impact can cause disturbances in the psychic and social sphere of the patient, causing problems in interpersonal relationships and in the body image itself. The use of skin expanders is usually effective in this region due to the bone base providing support and stability for its use. Read More

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The Effect of Fat Grafting on Expansion Pressures in Expander-Based Postmastectomy Breast Reconstruction: Outcomes in Normal and Irradiated Tissues.

Ann Plast Surg 2022 06;88(5 Suppl 5):S455-S460

Cancer Cell Biology Group, Institut d'Investigació Sanitària Illes Balears, (IdISBa), Palma de Mallorca, Spain.

Introduction: The impact of fat grafting on the viscoelasticity of irradiated tissues is poorly defined. We investigate the effect of subcutaneous fat grafting on postmastectomy tissue expansion in patients undergoing delayed breast reconstruction. We quantify observed viscoelastic and trophic changes of the skin envelope. Read More

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Metformin Promotes Mechanical Stretch-Induced Skin Regeneration by Improving the Proliferative Activity of Skin-Derived Stem Cells.

Front Med (Lausanne) 2022 24;9:813917. Epub 2022 May 24.

Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Background: Skin expansion by mechanical stretch is an essential and widely used treatment for tissue defects in plastic and reconstructive surgery; however, the regenerative capacity of mechanically stretched skin limits clinical treatment results. Here, we propose a strategy to enhance the regenerative ability of mechanically stretched skin by topical application of metformin.

Methods: We established a mechanically stretched scalp model in male rats ( = 20), followed by their random division into two groups: metformin-treated ( = 10) and control ( = 10) groups. Read More

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Retention of Donor T Cells in Lymphohematopoietic Tissue and Augmentation of Tissue PD-L1 Protection for Prevention of GVHD While Preserving GVL Activity.

Front Immunol 2022 23;13:907673. Epub 2022 May 23.

Arthur D. Riggs Diabetes and Metabolism Research Institute, The Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, Unites States.

Allogeneic hematopoietic cell transplantation (Allo-HCT) is a curative therapy for hematological malignancies (i.e., leukemia and lymphoma) due to the graft-versus-leukemia (GVL) activity mediated by alloreactive T cells that can eliminate residual malignant cells and prevent relapse. Read More

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Silicone-Textile Composite Resistive Strain Sensors for Human Motion-Related Parameters.

Sensors (Basel) 2022 May 23;22(10). Epub 2022 May 23.

Unit of Measurements and Biomedical Instrumentation, Departmental Faculty of Engineering, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 00128 Rome, Italy.

In recent years, soft and flexible strain sensors have found application in wearable devices for monitoring human motion and physiological parameters. Conductive textile-based sensors are good candidates for developing these sensors. However, their robust electro-mechanical connection and susceptibility to environmental factors are still an open challenge to date. Read More

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An Up-To-Date Review Regarding Cutaneous Benefits of L. Essential Oil.

Antibiotics (Basel) 2022 Apr 20;11(5). Epub 2022 Apr 20.

Department of Pharmacognosy, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.

Due to the plethora of pharmacological activities reported in the literature, L. is a valuable aromatic plant for the medicine of the XXI century. Recent studies highlight that L. Read More

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Tolerance of a Vascularized Composite Allograft Achieved in MHC Class-I-mismatch Swine Mixed Chimerism.

Front Immunol 2022 10;13:829406. Epub 2022 May 10.

Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.

Background: Vascularized composite allografts (VCAs) allow reconstruction of devastating injuries and amputations, yet require lifelong immunosuppression that is associated with significant morbidity. Induction of immune tolerance of VCAs would permit widespread use of these procedures. VCAs are acquired from deceased donors most likely to be -MHC-mismatched (in contrast to living-related renal transplant donor-recipient pairs matched at one MHC haplotype). Read More

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[Effects of expanded frontal-parietal pedicled flap in reconstructing cervical scar contracture deformity in children after burns].

Zhonghua Shao Shang Za Zhi 2022 May;38(5):454-461

Department of Burns, Zhengzhou First People's Hospital, Zhengzhou 450004, China.

To explore the effects of expanded frontal-parietal pedicled flap in reconstructing cervical scar contracture deformity in children after burns. A retrospective observational study was conducted. From January 2015 to December 2020, 18 male children with cervical scar contracture deformity after burns who met the inclusion criteria were admitted to Zhengzhou First People's Hospital, aged 4 to 12 years, including 10 cases with degree Ⅱ cervical scar contracture deformity and 8 cases with degree Ⅲ scar contracture deformity, and were all reconstructed with expanded frontal-parietal pedicled flap. Read More

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Surgical management of facial congenital melanocytic nevi: Experiences and outcomes at an academic center.

J Cosmet Dermatol 2022 May 20. Epub 2022 May 20.

Department of Brun and Plastic Surgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorder, Chongqing, China.

Background: Congenital melanocytic nevi (CMN), benign pigmented birthmarks caused by the mutation of melanocytic cells during embryofetal development, can cause aesthetic problem when it is located on the face. Surgical managements of facial CMN are required by both pediatric patients and their parents. Surgical management, including excision or staged excision, skin grafting, dermabrasion, tissue expansion or multiple re-expansion combined with flaps transplantation, have been reported previously. Read More

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Differential regulation of CD8 CD86 Vγ1.1 γδT cell responses in skin barrier tissue protection and homeostatic maintenance.

Eur J Immunol 2022 May 17. Epub 2022 May 17.

Department of Microbiology, Immunology, and Molecular Genetics, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA.

Compared to αβT cells, γδT cells are more innate-like and preferentially function as the first line of defense in barrier tissues. Certain populations of γδT cells possess adaptive immune cell properties but their regulation is not well understood. We herein report that while innate-like γδT17 cells dominated in the skin of WT mice, Vγ1. Read More

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Staged Ilizarov distraction histogenesis and corrective reconstruction for severe malunited calcaneal fractures.

Arch Orthop Trauma Surg 2022 May 6. Epub 2022 May 6.

Department of Orthopaedic Surgery, West China Hospital, Sichuan University, No. 37, Guoxue Avenue, Chengdu, 610041, Sichuan, China.

Purpose: Severe calcaneal malunion is a clinical conundrum for the difficulty of calcaneal reconstruction without soft tissue complications. The aim of this study is to introduce the treatment strategy and preliminary results of staged Illizarov distraction histogenesis and corrective reconstruction for severe malunion of calcaneal fractures.

Methods: From June 2014 to May 2020, 14 patients with severe calcaneal malunion treated with the staged strategy were retrospectively analyzed. Read More

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Identification of Common Hub Genes in Human Dermal Fibroblasts Stimulated by Mechanical Stretch at Both the Early and Late Stages.

Front Surg 2022 18;9:846161. Epub 2022 Apr 18.

Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Background: Mechanical stretch is vital for soft tissue regeneration and development and is utilized by plastic surgeons for tissue expansion. Identifying the common hub genes in human dermal fibroblasts (HDFs) stimulated by mechanical stretch at different stages will help elucidate the mechanisms involved and improve the efficiency of tissue expansion.

Methods: A gene expression dataset (GSE58389) was downloaded from the Gene Expression Omnibus database. Read More

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Complication Profile of Total Submuscular Versus Prepectoral Tissue Expander Placement: A Retrospective Cohort Study.

Ann Plast Surg 2022 06 23;88(5 Suppl 5):S439-S442. Epub 2022 Apr 23.

Department of Women's Oncology, Breast Program, H. Lee Moffitt Cancer Center, Tampa, FL.

Background: We sought to compare the safety profile of prepectoral breast reconstruction with total submuscular tissue expander reconstruction, previously our standard. Primary outcomes of interest in this retrospective cohort study were incidence of infection, hematoma, seroma, mastectomy flap necrosis, and reconstruction loss.

Methods: Total submuscular and prepectoral with acellular dermal matrix reconstructions consecutively performed by a single surgeon (P. Read More

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Air versus Saline: The Effect of Tissue Expander Fill on Outcomes of Prepectoral Breast Reconstruction.

Plast Reconstr Surg 2022 Jul 2;150(1):28-36. Epub 2022 May 2.

From the Department of Plastic and Reconstructive Surgery, Johns Hopkins Hospital; and Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine.

Background: Traditionally, saline is used for intraoperative/postoperative expansion in two-stage alloplastic breast reconstruction. Recently, intraoperative expansion with air has been proposed, to reduce pressure on the mastectomy skin flap in the immediate postoperative setting. The authors examined whether the intraoperative tissue expansion medium (i. Read More

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Mechanical tension mobilizes Lgr6 epidermal stem cells to drive skin growth.

Sci Adv 2022 04 27;8(17):eabl8698. Epub 2022 Apr 27.

Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21231, USA.

Uniquely among mammalian organs, skin is capable of marked size change in adults, yet the mechanisms underlying this notable capacity are unclear. Here, we use a system of controlled tissue expansion in mice to uncover cellular and molecular determinants of skin growth. Through machine learning-guided three-dimensional tissue reconstruction, we capture morphometric changes in growing skin. Read More

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Deconvolution of Adult T-Cell Leukemia/Lymphoma With Single-Cell RNA-Seq Using Frozen Archived Skin Tissue Reveals New Subset of Cancer-Associated Fibroblast.

Front Immunol 2022 7;13:856363. Epub 2022 Apr 7.

Genome Medicine Institute, Seoul National University College of Medicine, Seoul, South Korea.

Adult T-cell Leukemia/Lymphoma (ATLL) is a rare aggressive T-cell malignancy caused by human T-cell leukemia virus type 1 (HTLV-1) infection. However, little is known about the underlying activated molecular pathways at the single cell level. Moreover, the intercellular communications between the tumor microenvironment (TME) and tumor cells in this malignancy are currently unknown. Read More

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[Clinical effects of free transplantation of expanded thoracodorsal artery perforator flaps in reconstructing cervical cicatrix contracture deformity after burns].

Zhonghua Shao Shang Za Zhi 2022 Apr;38(4):328-334

Department of Burns and Cutaneous Surgery, Burn Center of PLA, the First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China.

To explore the clinical effects of free transplantation of expanded thoracodorsal artery perforator flaps in reconstructing cervical cicatrix contracture deformity after burns. A retrospective observational study was conducted. From May 2018 to April 2021, 11 patients with cervical cicatrix contracture deformity after burns who met the inclusion criteria were admitted to the First Affiliated Hospital of Air Force Medical University, including 3 males and 8 females, aged 5 to 46 years, with a course of cervical cicatrix contracture deformity of 5 months to 8 years. Read More

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[Clinical effects of free transplantation of expanded ilioinguinal flaps in the reconstruction of severe scar contracture deformity after extensive burns].

Zhonghua Shao Shang Za Zhi 2022 Apr;38(4):321-327

Department of Burns, Tongren Hospital of Wuhan University & Wuhan Third Hospital, Wuhan 430060, China.

To investigate the clinical effects of free transplantation of expanded ilioinguinal flaps in the reconstruction of severe scar contracture after extensive burns. A retrospective observational study was conducted. From August 2017 to October 2021, 7 patients with severe scar contracture deformity caused by extensive burns were hospitalized in Tongren Hospital of Wuhan University & Wuhan Third Hospital, including 5 males and 2 females, aged 26-65 years, with scar area of 20 cm×4 cm-34 cm×14 cm. Read More

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[Clinical application of expanded internal mammary artery perforator flap combined with vascular supercharge in reconstruction of faciocervical scar].

Zhonghua Shao Shang Za Zhi 2022 Apr;38(4):313-320

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.

To summarize the clinical experience of expanded internal mammary artery perforator (IMAP) flap combined with vascular supercharge in reconstruction of faciocervical scar. The retrospective observational study was conducted. From September 2012 to May 2021, 23 patients with postburn or posttraumatic faciocervical scars who met the inclusion criteria were admitted to Shanghai Ninth People's Hospital of Shanghai Jiao Tong University School of Medicine, including 18 males and 5 females, aged from 11 to 58 years, all of whom were reconstructed with expanded IMAP flaps. Read More

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[Aesthetic reconstruction of the scar contracture deformity in chin and neck with expanded flaps based on the "MRIS" principle].

Zhonghua Shao Shang Za Zhi 2022 Apr;38(4):306-312

Department of Plastic Surgery, State Key Laboratory of Trauma, Burns and Combined Injury, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing 400038, China.

The surgical reconstruction strategy for scar contracture deformity in chin and neck was explored, aiming to obtain better aesthetic outcome. A retrospective observational study was conducted. From December 2017 to April 2021, 34 patients with scar contracture deformity in chin and neck after burns were hospitalized in the Department of Plastic Surgery of the First Affiliated Hospital of Army Medical University (the Third Military Medical University), aged 12-54 years, including 13 males and 21 females, 4 cases with chin affected only, 7 cases with neck affected only, and 23 cases with both chin and neck affected. Read More

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[Application of skin and soft tissue expansion in repairing pediatric patients with superficial defects].

Authors:
X J Ma J K Ding

Zhonghua Shao Shang Za Zhi 2022 Apr;38(4):301-305

Department of Plastic Surgery, the First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China.

Skin and soft tissue expansion can provide skin tissue similar to the recipient area in color and texture, which is one of the ideal methods in the repair of superficial defects. However, due to the long treatment cycle and relatively high complications rate in pediatric patients, expansion still faces many challenges. Based on the clinical practice and the current progress in skin and soft tissue expansion, this paper briefly discusses the change of skin after expansion, and the application, prevention and treatment of complications in the application of expansion in pediatric patients, aiming to provide reference for expansion in pediatric patients. Read More

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Tissue Sodium Accumulation: Pathophysiology and Clinical Implications.

Antioxidants (Basel) 2022 Apr 9;11(4). Epub 2022 Apr 9.

National Laboratory for Human Reproduction, University of Pécs, 7624 Pécs, Hungary.

Excessive sodium intake has been well established as a risk factor for the development and progression of cardiovascular and renal diseases. Its adverse effects are achieved by renal sodium retention and related volume expansion and by inducing low-grade inflammation and oxidative stress (OS) in the target tissues. This review presents the recent concept of nonosmotic sodium storage in the skin interstitium, the subsequent dissociation of sodium and volume homeostasis, and the cellular response to the increased tissue sodium concentration. Read More

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First Successful Separation of Craniopagus Twins in India-Plastic Surgical Considerations.

Indian J Plast Surg 2022 Feb 25;55(1):36-44. Epub 2022 Feb 25.

Department of Plastic Reconstructive and Burns Surgery, Burns & Plastic Surgery Block, All India Institute of Medical Sciences New Delhi, India.

Separation of total vertical craniopagus with shared venous sinuses poses multiple challenges. Provision of soft-tissue cover to the exposed brains at the time of total separation is one of them, due to the large size of the defect and paucity of local tissues. Staged separation of twins is advised with partial venous and parenchymal disconnection in the first stage and total separation in the second stage. Read More

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February 2022

[The surgical activity of medical organizations providing out-patient medical care in The Russian Federation].

Authors:
S I Shlyafer

Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med 2022 Mar;30(2):264-269

The Federal State Budget Institution "The Central Research Institute for Health Organization and Informatics" of Minzdrav of Russia, 127254, Moscow, Russia,

One of important directions in improving effectiveness of out-patient surgical medical care is development of in-patient replacement forms. The purpose of the study. is to investigate volume of surgical work performed in medical organizations providing outpatient care in the Russian Federation in 2010-2019. Read More

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HSV-2-Specific Human Female Reproductive Tract Tissue Resident Memory T Cells Recognize Diverse HSV Antigens.

Front Immunol 2022 31;13:867962. Epub 2022 Mar 31.

Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, United States.

Antigen-specific T persist and protect against skin or female reproductive tract (FRT) HSV infection. As the pathogenesis of HSV differs between humans and model organisms, we focus on humans with well-characterized recurrent genital HSV-2 infection. Human CD8+ T persisting at sites of healed human HSV-2 lesions have an activated phenotype but it is unclear if T can be cultivated . Read More

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Non HCV-Related Mixed Cryoglobulinemic Vasculitis With Biopsy-Proven Renal Involvement: The Effects of Rituximab.

Front Med (Lausanne) 2022 28;9:819320. Epub 2022 Mar 28.

Nephrology and Dialysis Unit (The European Rare Kidney Disease Reference Network, The European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases, and the European Reference Network That Aims at Improving the Care of Patients With Rare Immunological Disorders), Center of Research of Immunopathology and Rare Diseases- Coordinating Center of the Network for Rare Diseases of Piedmont and Aosta Valley, Department of Clinical and Biological Sciences, University of Turin and S. Giovanni Bosco Hub Hospital, Turin, Italy.

In the countries where HCV infection is still endemic, about 90% of subjects with mixed cryoglobulinemia had previously been infected with HCV and about 80% are RNA positive. Remarkable results in severe HCV-related cryoglobulinemic vasculitis have been obtained with Rituximab. Details of the clinical characteristics and effective treatment of non HCV-related cryogloulinemic syndromes are presently lacking. Read More

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Delayed two-stage nipple sparing mastectomy and simultaneous expander-to-implant reconstruction of the large and ptotic breast.

Gland Surg 2022 Mar;11(3):524-534

Department of Family Medicine and Population Health, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.

Background: Large and ptotic breasts are considered an anatomical contraindication for nipple sparing mastectomy (NSM). Necrosis rates can be as high as 76%. The authors examined whether targeted preshaping mastopexy/reduction combined with simultaneous two-stage preshaping of the implant pocket prepares for an uneventful implant reconstruction. Read More

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