3,091 results match your criteria Skin Tissue Expansion

CMM-Net: Contextual multi-scale multi-level network for efficient biomedical image segmentation.

Sci Rep 2021 May 13;11(1):10191. Epub 2021 May 13.

Department of Electrical and Electronic Engineering, College of Engineering, Yonsei University, Seoul, Republic of Korea.

Medical image segmentation of tissue abnormalities, key organs, or blood vascular system is of great significance for any computerized diagnostic system. However, automatic segmentation in medical image analysis is a challenging task since it requires sophisticated knowledge of the target organ anatomy. This paper develops an end-to-end deep learning segmentation method called Contextual Multi-Scale Multi-Level Network (CMM-Net). Read More

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Natural killer T-cell lymphoma causing bilateral recurrent recalcitrant dacryocystitis.

Orbit 2021 May 11:1-5. Epub 2021 May 11.

Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA.

A 35-year-old female with a history of chronic extensive rhinosinusitis, previously treated twice with functional endoscopic sinus surgery, presented with recurrent dacryocystitis despite prior dacryocystorhinostomy. Histopathological specimens taken at the most recent sinus surgery demonstrated a lymphocytic inflammatory reaction without evidence of angiodestruction or necrosis. Flow cytometry was normal. Read More

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ASCs derived from burn patients are more prone to increased oxidative metabolism and reactive oxygen species upon passaging.

Stem Cell Res Ther 2021 May 6;12(1):270. Epub 2021 May 6.

United States Army Institute of Surgical Research, JBSA Fort Sam Houston, 3698 Chambers Pass, San Antonio, TX, USA.

Background: Patients with severe burn injury (over 20% of the total body surface area) experience profound hypermetabolism which significantly prolongs wound healing. Adipose-derived stem cells (ASCs) have been proposed as an attractive solution for treating burn wounds, including the potential for autologous ASC expansion. While subcutaneous adipocytes display an altered metabolic profile post-burn, it is not known if this is the case with the stem cells associated with the adipose tissue. Read More

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Osteosarcoma of the temporal bone occurring 40 years after radiotherapy: A technical case report presenting resection of intra- and extracranial lesions followed by a one-stage reconstruction.

Surg Neurol Int 2021 14;12:152. Epub 2021 Apr 14.

Department of Pathology, Harasanshin Hospital, Hakata-ku, Fukuoka, Japan.

Background: Osteosarcoma (OS) is a malignant tumor of the bone, which rarely occurs in the head-and-neck regions as a primary or a secondary malignancy. Adequate surgical resection is currently the mainstay of treatment for head-and-neck OS; however, resection and reconstruction can be difficult because the anatomies of these regions are complex. We present a case of an OS arising from the temporal bone 40 years after radiation therapy, which was successfully treated with resection and a one-stage reconstruction using intraoperative tissue expansion technique. Read More

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Gated Radiotherapy Development and its Expansion.

J Biomed Phys Eng 2021 Apr 1;11(2):239-256. Epub 2021 Apr 1.

PhD, Department of Medical Physics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

One of the most important challenges in treatment of patients with cancerous tumors of chest and abdominal areas is organ movement. The delivery of treatment radiation doses to tumor tissue is a challenging matter while protecting healthy and radio sensitive tissues. Since the movement of organs due to respiration causes a discrepancy in the middle of planned and delivered dose distributions. Read More

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Repair Exposure of the Postauricular Tissue Expander Using the Modified Brent Method: A 7-Year Experience.

Ear Nose Throat J 2021 Apr 29:1455613211007967. Epub 2021 Apr 29.

Department of Ear Reconstruction, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Shijingshan District, Beijing, People's Republic of China.

Objectives: Ear reconstruction is a challenging surgery for the complicated conditions in patients with microtia. The tissue expansion techniques were necessary and relatively safe for patients with insufficient soft tissue. However, complications such as necrosis of expanded flap and exposure of tissue expander limited the popularization of this method. Read More

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Periodontal (formerly type VIII) Ehlers-Danlos syndrome: Description of 13 novel cases and expansion of the clinical phenotype.

Clin Genet 2021 Apr 23. Epub 2021 Apr 23.

Clinique Dermatologique, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.

Periodontal Ehlers-Danlos syndrome (pEDS) is a rare condition caused by pathogenic variants in the C1R and C1S genes, encoding subunits C1r and C1s of the first component of the classical complement pathway. It is characterized by early-onset periodontitis with premature tooth loss, pretibial hyperpigmentation and skin fragility. Rare arterial complications have been reported, but venous insufficiency is rarely described. Read More

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A randomized, controlled clinical trial of autologous stromal vascular fraction cells transplantation to promote mechanical stretch-induced skin regeneration.

Stem Cell Res Ther 2021 Apr 15;12(1):243. Epub 2021 Apr 15.

Department of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizhaoju Road, Shanghai, 200011, People's Republic of China.

Background: The regeneration response of the skin to mechanical stretching in vivo has been explored in reconstructive surgery to repair large-scale deformities. The ability of the skin to regenerate limits the reconstructive outcome. Here, we propose an approach in which autologous stromal vascular fraction (SVF) cells and mechanical stretching are combined to overcome this limitation and promote skin regeneration. Read More

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Interaction between Staphylococcus Agr virulence and neutrophils regulates pathogen expansion in the skin.

Cell Host Microbe 2021 Apr 7. Epub 2021 Apr 7.

Department of Pathology and Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:

Staphylococcus aureus commonly infects the skin, but the host-pathogen interactions controlling bacterial growth remain unclear. S. aureus virulence is regulated by the Agr quorum-sensing system that controls factors including phenol-soluble modulins (PSMs), a group of cytotoxic peptides. Read More

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Oral Exposure to House Dust Mite Activates Intestinal Innate Immunity.

Foods 2021 Mar 9;10(3). Epub 2021 Mar 9.

Instituto de Investigación en Ciencias de la Alimentación (CIAL, CSIC-UAM), 28049 Madrid, Spain.

Scope: House dust mite (HDM) induces Th2 responses in lungs and skin, but its effects in the intestine are poorly known. We aimed to study the involvement of HDM in the initial events that would promote sensitization through the oral route and eventually lead to allergy development.

Methods And Results: BALB/c mice were exposed intragastrically to proteolytically active and inactive HDM, as such, or in combination with egg white (EW), and inflammatory and type 2 responses were evaluated. Read More

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Safety of CPX4 Breast Tissue Expanders in Primary Reconstruction Patients.

Plast Reconstr Surg Glob Open 2021 Mar 26;9(3):e3425. Epub 2021 Mar 26.

Artisan Plastic Surgery, LLC, Atlanta, Ga.

In the United States, 2-stage expander-to-implant-based breast reconstruction accounts for more than half of all breast reconstruction procedures. Tissue expansion technology has undergone significant advancements in the past few decades. Previous reports suggest that the most common perioperative complications associated with breast tissue expanders are infection and skin flap necrosis. Read More

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Biomechanical Effects of Unidirectional Expansion Using Anisotropic Expanders in Horse Skin Tissue.

J Equine Vet Sci 2021 04 3;99:103399. Epub 2021 Feb 3.

Department of Materials, University of Oxford, Parks Road, OX1 3PH, United Kingdom.

The use of a self-inflating tissue expander is a technique to stretch cutaneous tissues for potential use in reconstructive skin surgeries. This study investigates the mechanical properties of horse skin stretched by the subcutaneous implantation of anisotropic tissue expanders at the forehead, right shoulder, and dorsomedial part of the cannon region of the right forelimb in six (n = 6) horses. After 14 days of skin expansion, expanded and normal (control) skin samples were harvested and their mechanical properties of elastic modulus (EM), maximum force (MF), maximum stress (MSs) and maximum strain (MSr) were evaluated using uniaxial tension test. Read More

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Structural basis of Blastomyces Endoglucanase-2 adjuvancy in anti-fungal and -viral immunity.

PLoS Pathog 2021 Mar 18;17(3):e1009324. Epub 2021 Mar 18.

Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.

The development of safe subunit vaccines requires adjuvants that augment immunogenicity of non-replicating protein-based antigens. Current vaccines against infectious diseases preferentially induce protective antibodies driven by adjuvants such as alum. However, the contribution of antibody to host defense is limited for certain classes of infectious diseases such as fungi, whereas animal studies and clinical observations implicate cellular immunity as an essential component of the resolution of fungal pathogens. Read More

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Continuous External Tissue Expansion Closure Technique for Management of Forearm Compartment Syndrome Releases and Simple Upper-Extremity Wounds.

J Hand Surg Am 2021 Mar 12. Epub 2021 Mar 12.

Division of Hand Surgery, Department of Orthopedic Surgery, University of Miami Miller School of Medicine, Miami, FL. Electronic address:

Upper-extremity wounds from various etiologies such as trauma and fasciotomies can prove to be problematic for the upper-extremity surgeon. These defects can result in considerable morbidity often requiring prolonged wound care and the eventual use of skin grafting from a separate painful donor site. Tissue expansion takes advantage of the viscoelastic properties of skin to provide additional tissue for reconstruction. Read More

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Explantation in Tissue Expander and Direct-to-Implant Reconstruction with Acellular Dermal Matrix: How to Avoid Early Reconstructive Failures.

Plast Reconstr Surg 2021 04;147(4):579e-586e

From the Department of Plastic Surgery, Memorial Sloan Kettering Cancer Center.

Background: In the United States, approximately 57,000 tissue expander/implant-based breast reconstructions are performed each year. Complete submuscular tissue expander coverage affords the best protection against implant exposure but can restrict lower pole expansion. The benefits of using acellular dermal matrix are enticing, but questions remain as to whether or not its presence increases reconstructive failures. Read More

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Phenotypic analysis of Pyrin-Associated Autoinflammation with Neutrophilic Dermatosis patients during treatment.

Rheumatology (Oxford) 2021 Mar 8. Epub 2021 Mar 8.

KU Leuven, Department of Microbiology and Immunology, Leuven, Belgium.

Objective: In 2016 specific heterozygous gain-of-function mutations in MEFV were reported causal for a distinct autoinflammatory disease coined pyrin-associated autoinflammation with neutrophilic dermatosis (PAAND). We sought to provide an extended report on clinical manifestations in PAAND patients to date and evaluate the efficacy and safety of treatment with the IL-1-blocking agent anakinra.

Methods: We undertook an open-label pilot study with anakinra. Read More

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Thermal conditioning improves quality and speed of keratinocyte sheet production for burn wound treatment.

Cytotherapy 2021 Mar 5. Epub 2021 Mar 5.

Center for Applied Biotechnology and Molecular Medicine, Zurich, Switzerland; Department of Plastic Surgery and Hand Surgery, University Hospital Zurich, Zurich, Switzerland.

Background Aims: Cultured patient-specific keratinocyte sheets have been used clinically since the 1970s for the treatment of large severe burns. However, despite significant developments in recent years, successful and sustainable treatment is still a challenge. Reliable, high-quality grafts with faster availability and a flexible time window for transplantation are required to improve clinical outcomes. Read More

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γδ T Cells in Merkel Cell Carcinomas Have a Proinflammatory Profile Prognostic of Patient Survival.

Cancer Immunol Res 2021 Mar 5. Epub 2021 Mar 5.

Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.

Merkel cell carcinomas (MCC) are immunogenic skin cancers associated with viral infection or UV mutagenesis. To study T-cell infiltrates in MCC, we analyzed 58 MCC lesions from 39 patients using multiplex-IHC/immunofluorescence (m-IHC/IF). CD4 or CD8 T cells comprised the majority of infiltrating T lymphocytes in most tumors. Read More

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Supraclavicular Flap for Severe Post-burn Neck Contracture in Children.

Cureus 2021 Jan 25;13(1):e12910. Epub 2021 Jan 25.

Trauma, Olympia Hospital & Research Centre, Trichy, IND.

The neck is essential and vital for all head movements and performing daily functional activities. The second-degree deep dermal and full-thickness burns causing anterior neck contracture restricts movement and if untreated develop deformities, in the oral cavity, eyes, posture, and chin growth and development, especially in children. Neck contracture results in kyphoscoliosis, lower lip seal resulting in impaired vision, balance, swallowing, feeding, and speech as well as social stigma, depression, and embarrassment. Read More

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January 2021

Pathophysiology of Skin Resident Memory T Cells.

Front Immunol 2020 3;11:618897. Epub 2021 Feb 3.

Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Tissue resident memory T (T) cells reside in peripheral, non-lymphoid tissues such as the skin, where they act as alarm-sensor cells or cytotoxic cells. Physiologically, skin T cells persist for a long term and can be reactivated upon reinfection with the same antigen, thus serving as peripheral sentinels in the immune surveillance network. CD8CD69CD103 T cells are the well-characterized subtype that develops in the epidermis. Read More

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February 2021

Encephalocraniocutaneous Lipomatosis Associated with Orbital Cyst: A Variant or New Entity?

Turk J Ophthalmol 2021 Feb;51(1):66-69

University of Maiduguri Teaching Hospital, Department of Pediatrics, Maiduguri, Nigeria.

Encephalocraniocutaneous lipomatosis (ECCL), also known as Haberland or Fishman syndrome, is an extremely rare congenital neurocutaneous disorder that characteristically involves ectomesodermal tissues such as the central nervous system, eyes, and skin. The etiology of the disease remains unknown. Here we present a rare case of ECCL associated with bilateral eye involvement and orbital cyst from Sub-Saharan Africa. Read More

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February 2021

Clonal expansion in non-cancer tissues.

Nat Rev Cancer 2021 04 24;21(4):239-256. Epub 2021 Feb 24.

Department of Pathology and Tumour Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Cancer is a clonal disorder derived from a single ancestor cell and its progenies that are positively selected by acquisition of 'driver mutations'. However, the evolution of positively selected clones does not necessarily imply the presence of cancer. On the contrary, it has become clear that expansion of these clones in phenotypically normal or non-cancer tissues is commonly seen in association with ageing and/or in response to environmental insults and chronic inflammation. Read More

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[Indocyanine green angiography technique assisted brachial artery perforator propeller flap to repair soft tissue defects of trunk and upper limb].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Feb;35(2):200-205

Scar Comprehensive Treatment Center, Plastic Surgery Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100144, P.R.China.

Objective: To explore the feasibility of using indocyanine green (ICG) angiography to detect brachial artery perforators, and the clinical application of brachial artery perforator propeller (BAPP) flaps to repair soft tissue defects of the trunk and upper limbs.

Methods: Between August 2016 and February 2019, ICG angiography was used to detect the perforating vessels of the brachial artery muscle septum, and the BAPP flaps were cut out with the detected perforating vessels as the pedicle to repair 19 cases of trunk and upper limb soft tissue defects. There were 12 males and 7 females, with an average age of 28. Read More

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February 2021

Systematic Review of Tissue Expansion: Utilization in Non-breast Applications.

Plast Reconstr Surg Glob Open 2021 Jan 21;9(1):e3378. Epub 2021 Jan 21.

Division of Plastic, Reconstructive, Maxillofacial and Oral Surgery, Duke University Medical Center, Durham, N.C.

Background: Tissue expansion is a versatile reconstructive technique providing well-vascularized local tissue. The current literature focuses largely on tissue expansion for breast reconstruction and in the context of burn and pediatric skin/soft tissue replacement; however, less traditional applications are also prevalent. The aim of this study was to systematically review the utilization of tissue expansion in such less well-characterized circumstances. Read More

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January 2021

Reconstruction of Circumferential Upper Extremity Defect Using a Bipedicle Expanded Flank Flap.

Ann Plast Surg 2021 03;86(3):279-286

No. 9 Department, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Resurfacing of extensive upper extremity lesions remains a challenge for plastic surgeons because of optimal functional and aesthetic outcomes and limitations of flap size. We introduced a pre-expanded flank flap to reconstruct the circumferential upper extremity defect in one sequence of tissue expansion.

Method: Between March 2015 and June 2019, 14 consecutive patients underwent reconstructive treatment for circumferential soft tissue lesions in the upper extremity using a bipedicle expanded flank flap. Read More

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A novel two-stage strategy combing tissue expansion and Nagata`s technique for total auricular reconstruction.

J Plast Reconstr Aesthet Surg 2021 Jan 10. Epub 2021 Jan 10.

Department of Ear Reconstruction, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

Background: This study was performed to explore the clinical application of the Nagata's technique for combing tissue expansion in auricular reconstruction.

Methods: The auricular reconstruction was performed in two surgical stages. At the first stage, an 80 ml expander was inserted in the mastoid region after preoperative evaluation. Read More

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January 2021

Pericyte migration and proliferation are tightly synchronized to endothelial cell sprouting dynamics.

Integr Biol (Camb) 2021 Feb;13(2):31-43

Center for Heart and Reparative Medicine Research, Fralin Biomedical Research Institute, Roanoke, VA 24014, USA.

Pericytes are critical for microvascular stability and maintenance, among other important physiological functions, yet their involvement in vessel formation processes remains poorly understood. To gain insight into pericyte behaviors during vascular remodeling, we developed two complementary tissue explant models utilizing 'double reporter' animals with fluorescently-labeled pericytes and endothelial cells (via Ng2:DsRed and Flk-1:eGFP genes, respectively). Time-lapse confocal imaging of active vessel remodeling within adult connective tissues and embryonic skin revealed a subset of pericytes detaching and migrating away from the vessel wall. Read More

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February 2021

The enigmatic role of HLA-B*27 in spondyloarthritis pathogenesis.

Semin Immunopathol 2021 Apr 22;43(2):235-243. Epub 2021 Jan 22.

Pediatric Translational Research Branch, National Institute of Arthritis, Musculoskeletal, and Skin Diseases, National Institutes of Health (NIH), Bethesda, MD, USA.

Establishing a clear role for HLA-B*27 in the pathogenesis of spondyloarthritis continues to be challenging. Aberrant properties of the heavy chain as well as a potential role presenting arthritogenic peptides continue to be pursued as plausible mechanisms. Recent studies implicate HLA-B*27 in aberrant bone formation. Read More

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Intraoperative tissue expansion to allow primary linear closure of 2 large adjacent surgical defects.

Cutis 2020 Nov;106(5):250-252

Department of Dermatologic Surgery, Silver Falls Dermatology, Salem, Oregon, USA.

It is becoming increasingly more common for dermatology patients to present for treatment of multiple skin cancers during the same appointment. When 2 lesions are close together, the final repair will need to take into consideration the final size of the adjacent defects, any normal tissue remaining between the defects, and the inherent tension of the tissue in those locations. The SUTUREGARD ISR device (Sutureguard Medical Inc) can allow intraoperative tissue expansion to decrease tension on the tissue and may provide the opportunity to allow primary linear closure for both defects as opposed to a much larger flap or graft repair. Read More

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November 2020

Mesenchymal Stem Cell Spheroids Embedded in an Injectable Thermosensitive Hydrogel: An In Situ Drug Formation Platform for Accelerated Wound Healing.

ACS Biomater Sci Eng 2020 09 27;6(9):5096-5109. Epub 2020 Aug 27.

Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.

The ability of mesenchymal stem cells (MSCs) to enhance cutaneous wound healing has been well established. Extensive expansion of cells to reach sufficient cell numbers for regenerating tissues has always limited cell-based therapies. An ingenious solution to address this challenge is to develop a strategy to increase the immunomodulatory effects of MSCs without expanding them. Read More

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September 2020