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Plast Reconstr Surg 2019 Jan;143(1):64-74

Dallas, Texas; and Miami, Fla. From the Department of Plastic Surgery, University of Texas Southwestern Medical Center; private practice; and Dallas Plastic Surgery Institute.

Background: Use of nonsurgical skin rejuvenation has grown over the past two decades. This has led to an increase in ablative and nonablative resurfacing devices. Moderate to heavy perioral rhytides require an ablative laser to maximize results. Read More

J Drugs Dermatol 2018 Nov;17(11):1157 - 1162

OBJECTIVE: The aim of this study was to evaluate the incidence of adverse effects following laser skin resurfacing with the microablative carbon dioxide (CO2) laser system (SmartXide DOT; DEKA, Calenzano, Italy). METHODS: A retrospective chart review was performed. Data was collected for DOT laser procedures performed at three clinical centers from 2008-2014. Read More

J Oral Maxillofac Surg 2018 Oct 27. Epub 2018 Oct 27.

Lecturer, Department of Oral & Maxillofacial Surgery, MGM Dental College & Hospital, Navi Mumbai, India.

Purpose: The purpose was to evaluate the clinical outcomes of laser skin resurfacing using an ultra-pulse carbon dioxide (CO) laser and manual dermabrasion with a medium-grit drywall sand screen for scar revision in adults with Fitzpatrick skin type III to V.

Materials And Methods: A total of 20 postsurgical and post-traumatic scars in individuals with Fitzpatrick skin type III to V were included in this study. Preoperative evaluation of the scars was performed by 3 blinded observers using the Manchester scar rating scale. Read More

Facial Plast Surg Clin North Am 2018 Nov 16;26(4):439-446. Epub 2018 Aug 16.

Department of Otolaryngology-Head and Neck Surgery, Weill Cornell Medicine, 1305 York Avenue, Fifth Floor, New York, NY 10021, USA. Electronic address:

Platelet preparations, including platelet-rich plasma and platelet-rich fibrin matrix, have been used to improve wound healing, recovery time, and cosmetic outcomes for facial rejuvenation. Bioactive growth factors released from platelets are the putative agents in producing a reparative tissue reaction in the treated area. Different methods of processing the patients' blood will yield different types of platelet preparations with different components and properties, and it is important to understand these differences and their potential implications. Read More

J Cosmet Laser Ther 2018 Sep 10:1-8. Epub 2018 Sep 10.

a Department of Dermatology , the First Affiliated Hospital of Nanjing Medical University , Nanjing , Jiangsu , China.

Background: Fractional carbon dioxide laser resurfacing (FxCR) is a routine treatment of Dermatology while many patients suffered the damage of skin barrier function after FxCR.

Objective: To evaluate the benefits of antimicrobial peptides (AMPs) and hyaluronic acid (HA) compound mask on wound healing after FxCR on human and mouse skin.

Methods: Twenty-four subjects were treated with FxCR on the bilateral cheeks. Read More

Aesthetic Plast Surg 2018 Aug 21. Epub 2018 Aug 21.

Department of Plastic and Reconstructive Surgery, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University, 1 Singil-ro, Yeongdeungpo-gu, Seoul, 07441, Republic of Korea.

Purpose: A linear surgical scar, when located in the head and neck region, can be a significant cosmetic concern. Laser skin resurfacing with a fractional laser and a pulsed dye laser has been proven to be useful for treating such scars. As alternatives, we used a classic ablative CO laser in continuous mode with a 1-mm spot size and a 595-nm Nd:YAG laser. Read More

J Cosmet Laser Ther 2018 Jul 18:1-2. Epub 2018 Jul 18.

a Department of Dermatology , Habib Thameur Hospital , Tunis , Tunisia.

Fractional photothermolysis was initially introduced by Manstein in 2004 .Fractional CO2 laser technology introduced has allowed physicians to obtain good cosmetic results with a lower rate of complications than non-fractionated ablative laser treatment. However, adverse effects may still occur. Read More

J Drugs Dermatol 2018 Jul;17(7):796-799

Background And Objective: Misperceptions have persisted regarding scanning full-field erbium laser that have caused it to be overshadowed by fractional ablative resurfacing. This can lead to sub-optimally treating the periocular and perioral skin. Our report describes the utility of a combined approach of fractional ablative CO2 with full-field erbium ablation for full face rejuvenation. Read More

J Cosmet Dermatol 2018 Oct 29;17(5):756-761. Epub 2018 Jun 29.

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Epidermal growth factor (EGF) is one of the important peptides in wound healing process. The effects of EGF have been increasingly studied in various types of ulcers. However, data on postablative laser resurfacing wound is still limited. Read More

Lasers Surg Med 2018 Dec 17;50(10):1010-1016. Epub 2018 Jun 17.

Department of Dermatology, University Medical Centre Regensburg, 93042, Regensburg, Germany.

Background: Fractional ablative resurfacing is frequently used for treating atrophic and acne scars as well as for the early improvement of scars after surgery. No evidence-based clinical data on improving the appearance of skin grafts by fractional CO -laser resurfacing have been available so far.

Objectives: The primary outcome parameter was the adaptation of the skin graft to the surrounding skin 2, 6, and 12 months after the second laser treatment. Read More

Lasers Med Sci 2018 Sep 30;33(7):1485-1491. Epub 2018 Apr 30.

Student Hospital, Cairo, Egypt.

Pseudo-acanthosis nigricans is a common dermatological disorder that is usually difficult to treat secondary to maceration of the skin from excessive sweating, obesity, or associated with endocrine disorders. Fractional photothermolysis and chemical peeling have been reported to improve the condition. To determine whether fractional CO laser resurfacing or glycolic acid peel is more effective and safe option for therapy. Read More

Int J Dermatol 2018 Apr 12;57(4):480-487. Epub 2018 Feb 12.

Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Pathumwan, Bangkok, Thailand.

Proven as effective acne scar treatment, ablative fractional carbon dioxide (AFCO ) laser requires post-laser wound healing care. MAS063DP is a multicomponent nonsteroidal anti-inflammatory moisturizer for effective post-laser treatment. This study compares the efficacy of MAS063DP and 0. Read More

J Cosmet Laser Ther 2018 Jun 13;20(3):168-178. Epub 2017 Dec 13.

b Department of Plastic Surgery, Southern Medical University , Tonghe , Guangzhou , China.

Objective: Laser skin resurfacing (LSR) has been used for facial rejuvenation for the last 20 years. Posttreatment care after LSR is essential to decrease the risk of complications. Currently, no unified standards or criteria exist for invasive LSR posttreatment care. Read More

J Drugs Dermatol 2017 Nov;16(11):1085-1090

BACKGROUND: Fractional ablative lasers have been shown to be safe and effective for improving wrinkles, scars, skin texture, and dyspigmentation. However, the exact effects of this technology in vivo on epidermal and dermal skin constituents have not been delineated. This study evaluated the in vivo histological effects over time of treatment with a fractional ablative CO2 system, using different treatment parameters. Read More

BMJ Case Rep 2017 Oct 13;2017. Epub 2017 Oct 13.

Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

We describe a case of disfiguring facial pyoderma vegetans in order to highlight the challenges in managing this rare skin condition and review the literature.A 54-year-old woman presented to dermatology clinic with a 3-month history of a left-sided facial lesion, which had been treated as an infected sebaceous cyst. The lesion had dramatically increased in size in the weeks prior to presentation. Read More

JAMA Dermatol 2017 12;153(12):1292-1297

Department of Dermatology, Henry Ford Hospital, Detroit, Michigan.

Importance: Current models of Goltz syndrome cannot estimate the overall neocollagenesis and marked shift in collagen types after ablative fractional laser resurfacing (AFR) within treated areas of focal dermal hypoplasia (FDH).

Objectives: To clinically improve FDH by using AFR to characterize the specific ratio of collagen types associated with observed clinical changes.

Design, Setting, And Participants: This case report of a girl with Goltz syndrome used extensive laboratory evaluation and multiple observers blinded to the patient's clinical status. Read More

Clin Plast Surg 2017 Oct 21;44(4):757-766. Epub 2017 Jul 21.

Shriners Hospital for Children, 51 Blossom Street, Boston, MA 02114, USA.

In this review, the authors discuss the use of laser photothermolysis and laser resurfacing in the management of hypertrophic burn scars. They provide details regarding preoperative selection, intraoperative decision making, and postoperative care. Read More

JAMA Dermatol 2017 10;153(10):1021-1025

Department of Dermatology, University of Michigan Medical School, Ann Arbor.

Importance: Erosive pustular dermatosis (EPD) is a rare condition that typically affects actinically damaged skin of the scalp. Characterized by sterile pustules, erosions, and crusts, EPD is difficult to treat and heals slowly. The exact cause of EPD is unknown, although trauma is an inciting factor. Read More

Dermatol Surg 2017 Sep;43(9):1137-1143

*All authors are affiliated with the National Skin Centre, Singapore.

Background: Fractional carbon dioxide (CO2) laser resurfacing unites the idea of fractional photothermolysis with an ablative 10,600-nm wavelength. This technology permits effective treatment of acne scarring, with shorter recovery and a decreased side effect profile as compared to traditional CO2 laser resurfacing.

Objective: The aims of this study were to study the efficacy and safety of fractional CO2 laser for acne scars in Asian patients. Read More

J Drugs Dermatol 2017 Jul;16(7):707-710

INTRODUCTION: A topical proprietary procedural enhancement system (PES) containing a combination of active ingredients including a tripeptide and hexapeptide (TriHex Technology™, Alastin Procedure Enhancement Invasive System, ALASTIN Skincare™, Inc., Carlsbad, CA) has been used successfully to aid in healing and improve symptomatology following resurfacing procedures.

METHODS: PES (Gentle Cleanser, Regenerating Skin Nectar with TriHex Technology™, Ultra Nourishing Moisturizer with TriHex Technology™, Soothe + Protect Recovery Balm, Broad Spectrum 30+ Sunscreen) was compared to a basic regimen (Aquaphor™, Cerave™ cleanser, Vanicream™, Alastin Broad Spectrum 30+ Sunscreen) in a split face/ décolleté trial following fractional non-ablative thulium-doped resurfacing treatment to the face or décolleté. Read More

J Eur Acad Dermatol Venereol 2018 Jan 4;32(1):113-116. Epub 2017 Aug 4.

FAAD-FEADV Medical and Scientific Director, SDC The Skin Doctors Center, Trieste, Italy.

Background: Aesthetically pleasing results and fast, uneventful recovery are highly desirable after rejuvenating ablative laser procedures. Wound dressings following ablative laser procedures should ideally improve and optimize the wound healing environment.

Objective: The purpose of this comparative split-face, single-blinded, prospective observational study was to assess the efficacy and acceptability of two primary wound dressings immediately after a full-face fractional CO laser resurfacing procedure. Read More

Facial Plast Surg 2017 Jun 1;33(3):299-310. Epub 2017 Jun 1.

Meridian Plastic Surgery Center, Indianapolis, Indiana.

J Cosmet Laser Ther 2017 Aug 6;19(4):199-204. Epub 2017 Feb 6.

d Cochrane Taiwan , Taipei Medical University , Taipei , Taiwan.

Background: Laser resurfacing is used to minimize wrinkles, solar scars and sequelae of acne.

Objective: Purpose of the systematic review was to compare resurfacing outcomes of CO laser and erbium: yttrium aluminium garnet (erb:YAG) laser therapies.

Materials And Methods: Medline, Cochrane Library, EMBASE and Google Scholar databases were searched until 9 April 2015 using the following terms: laser, carbon dioxide/CO, facial wrinkles, rhytides and erbium-doped yttrium aluminium garnet/erbium:YAG/Er:YAG. Read More

J Drugs Dermatol 2016 Nov;15(11):1315-1319

Background & Objective: Surgical scars are an unwanted sequela following surgical procedures. Several different treatment modalities and approaches are currently being employed to improve the cosmesis of surgical scars with each having varying degrees of success. The objective of this study was to assess the ef cacy and safety pulsed dye laser treatment, CO2 ablative fractional resurfacing, and a combined treatment with these two modalities for the cosmetic improvement of surgical scarring that occurred following the surgical removal of skin cancer from different anatomic areas. Read More

J Am Acad Dermatol 2017 Feb;76(2):e53-e55

Department of Dermatology, Heinrich-Heine University, Düsseldorf, Germany. Electronic address:

Photomed Laser Surg 2017 May 12;35(5):278-281. Epub 2017 Jan 12.

Toyos Clinic , Nashville, Tennessee.

Fractional continuous wave CO laser resurfacing is used to improve photodamage, wrinkles, and acne scarring by surface ablation and by using heat to activate natural collagen production and dermal remodeling. In this study, the author examined the efficacy and safety of nonincisional continuous wave fractional CO laser blepharoplasty in the upper lid. Standard lid measurements including marginal reflex distance, palpebral fissure, and upper lid crease were performed preoperatively and at 6 months by the surgeon. Read More

Photomed Laser Surg 2017 Mar 30;35(3):171-175. Epub 2016 Dec 30.

4 "Laser in Dermatology, " University of Rome Tor Vergata , Rome, Italy .

Background: The CO laser has become the gold standard treatment in dermatologic surgery for the treatment of a large number of skin and mucosal lesions. The introduction of the fractional micro-ablative technology represented an integration to the ablative resurfacing technique, reducing the healing time and the side effects.

Objective: Vaginal rejuvenation performed with this technique is a minimally invasive procedure that stimulates internal tissues of the female lower genital tract to regenerate the mucosa, improving tissue trophism and restoring the correct functionality. Read More

Surgeon 2017 Dec 7;15(6):321-324. Epub 2016 Dec 7.

Department of Urology, NHS Greater Glasgow and Clyde, Glasgow, G51 4TF, Scotland, UK.

Introduction & Objective: The non-invasive nature of penile intraepithelial neoplasia (PeIN) allows for curative penile sparing therapy and is recommended, in their guidelines, by the European Association of Urology (EAU). Treatment options include topical chemotherapy, immunotherapy, laser treatment, photodynamic therapy and surgical excision. Our primary aim was to evaluate the outcome of carbon dioxide (CO) laser treatment of penile intraepithelial neoplasia. Read More

Lasers Med Sci 2017 Feb 24;32(2):283-289. Epub 2016 Nov 24.

Department of Dermatology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Ablative fractional lasers were introduced for treating facial rhytides. Few studies have compared fractional CO and Er:YAG lasers on cutaneous photodamages by a split trial. The aim of the present study was to compare these modalities in a randomized controlled double-blind split-face design with multiple sessions and larger sample size compared to previous studies done before. Read More

Lasers Med Sci 2017 Feb 24;32(2):291-295. Epub 2016 Nov 24.

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Pran-nok Road, Bangkok, 10700, Thailand.

Topical anaesthetic cream (TAC) is commonly used as a pre-treatment of ablative fractional resurfacing (AFR) laser. Most of anaesthetic cream contains distilled water as major component. Therefore, pre-operative TAC may interfere the photothermal reaction in the skin treated with fractional carbon-dioxide (FCO) laser and fractional erbium-doped yttrium aluminium garnet (FEr:YAG) laser. Read More

J Cosmet Laser Ther 2017 Feb 2;19(1):43-48. Epub 2016 Dec 2.

b Department of Dermatology , Seoul St. Mary's Hospital , Seoul , Republic of Korea.

Background: Polydeoxyribonucleotide (PDRN) is an active compound that can promote wound healing. PDRN stimulates wound healing by enhancing angiogenesis and increasing fibroblast growth rates. Laser skin resurfacing is a popular cosmetic procedure for skin rejuvenation. Read More

Medicine (Baltimore) 2016 Oct;95(42):e5168

aDepartment of Paediatric Surgery bDepartment of Paediatric Radiology cDepartment of Endocrynology, Medical University of Lublin, Lublin, Poland.

Treatment of hypertrophic scars arising as a result of thermal burns in children is still a big problem. The results of the treatment are not satisfactory for patients and parents, and new methods of treatment are still investigated.We present the use of one of the most modern carbon dioxide (CO2) lasers (Lumenis Encore laser equipped with a Synergistic Coagulation and Ablation for Advanced Resurfacing module) in the treatment of hypertrophic scars in children after burns. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Jan 23;123(1):e10-e15. Epub 2016 Aug 23.

Division of Oral and Maxillofacial Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Objective: Facial resurfacing with a CO laser has been used for treatment of pathologic lesions and for cosmetic purposes. Postoperative complications and problems after laser resurfacing include infections, acneiform lesions, and pigment changes. This retrospective study describes the most common problems and complications in 105 patients and assesses postoperative pain in 38 patients. Read More

Lasers Surg Med 2017 01 8;49(1):45-59. Epub 2016 Sep 8.

Division of Dermatology, Department of Medicine, University of Hong Kong, Hong Kong, SAR, China.

Background And Objective: Fractionated photothermolysis (FP) has revolutionized modern laser technology. By creating selective columns of microthermal damage, fractionated devices allows for greater treatment depths to be achieved without the prolonged downtime and risk of complications seen in traditional fully ablative laser resurfacing. Fractional resurfacing is a proven method to treat a variety of cutaneous conditions. Read More

Lasers Med Sci 2016 Nov 10;31(8):1707-1715. Epub 2016 Aug 10.

Department of Ophthalmology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Morphea is a rare fibrosing skin disorder that occurs as a result of abnormal homogenized collagen synthesis. Fractional ablative laser resurfacing has been used effectively in scar treatment via abnormal collagen degradation and induction of healthy collagen synthesis. Therefore, fractional ablative laser can provide an effective modality in treatment of morphea. Read More

J Cosmet Laser Ther 2016 Nov 5;18(7):387-388. Epub 2016 Aug 5.

a Department of Dermatology , Chung-Ang University College of Medicine , Seoul , South Korea.

Facial scars can be caused by a traumatic event or indeed surgical procedures. Several treatment modalities have been suggested including surgical or resurfacing techniques, autologous fat transfer, and injection of fillers. However, these approaches have varying degrees of success and associated side effects. Read More

Lasers Med Sci 2016 Nov 13;31(8):1607-1611. Epub 2016 Jul 13.

Department of Life, Health & Enviromental Sciences, Plastic and Reconstructive Surgery Section, University of L'Aquila, 67100, L'Aquila, Italy.

As known, fractional CO resurfacing treatments are more effective than non-ablative ones against aging signs, but post-operative redness and swelling prolong the overall downtime requiring up to steroid administration in order to reduce these local systems. In the last years, an increasing interest has been focused on the possible use of probiotics for treating inflammatory and allergic conditions suggesting that they can exert profound beneficial effects on skin homeostasis. In this work, the Authors report their experience on fractional CO laser resurfacing and provide the results of a new post-operative topical treatment with an experimental cream containing probiotic-derived active principles potentially able to modulate the inflammatory reaction associated to laser-treatment. Read More

Lasers Surg Med 2017 01 8;49(1):84-87. Epub 2016 Jul 8.

Dermatology and Laser Surgery Center, Houston, Texas.

Importance: The removal of café-au-lait macules (CALMs) in patients with darker skin phototypes poses a significant challenge due to limited available therapeutic options and increased risk of adverse effects, including permanent scarring and further dyspigmentation. Herein, we demonstrate the novel use of non-ablative fractional photothermolysis for the safe removal of CALMs in individuals with Fitzpatrick skin type (FST) IV-V.

Observations: Retrospective analysis of four patients (FST IV-V) with CALMs revealed that three of these patients had greater than 50% clearance after multiple treatment sessions with the non-ablative fractional 1,550-nm erbium-doped fiber laser. Read More

Clin Plast Surg 2016 Jul 13;43(3):515-25. Epub 2016 May 13.

New Jersey Plastic Surgery, 29 Park Street, Montclair, NJ 07042, USA.

Laser resurfacing is a very popular procedure worldwide. Full field and fractional lasers are used in many aesthetic practices. There have been significant advances in laser resurfacing in the past few years, which make patient treatments more efficacious and with less downtime. Read More

Open Access Maced J Med Sci 2016 Jun 24;4(2):271-6. Epub 2016 May 24.

Acibadem Sistina Clinical Hospital, Skopje, Republic of Macedonia.

Aim: The aim of the study was to confirm the efficiency and safety of the fractional CO2 laser in skin renewal and to check the possibility of having a synergistic effect in patients who besides carbon dioxide laser are treated with PRP (platelet-rich plasma) too.

Material And Methods: The first group (Examined Group 1 or EG1) included 107 patients treated with fractional CO2 laser (Lutronic eCO2) as mono-therapy. The second group (Control Group or CG) covered 100 patients treated with neither laser nor plasma in the same period but subjected to local therapy with drugs or other physio-procedures under the existing protocols for treatment of certain diseases. Read More

Clin Cosmet Investig Dermatol 2016 5;9:107-14. Epub 2016 May 5.

Instituto de Dermatologia Professor Rubem David Azulay, Santa Casa de Misericórdia do Rio de Janeiro, Rio de Janeiro, Brazil; Serviço de Anatomia Patológica da Faculdade de Medicina da Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

The description of atomic structure by Niels Bohr set the basis for the emergence of quantum physics. Based on these fundamentals, Einstein published in 1917 a paper on the amplification of energy by Stimulated Emission of Radiation as part of his quantum theories. In 1955, Townes and Gordon turned Einstein's theories into practice, creating a coherent and amplified microwave device using ammonia gas in an optical medium. Read More

J Cosmet Laser Ther 2016 Oct 2;18(6):352-4. Epub 2016 Jun 2.

a Laser Skin Care of Louisiana , Lafayette , LA , USA.

Fractional CO2 laser resurfacing using aggressive treatment parameters may result in adverse effects comparable to those of fully ablative CO2 laser resurfacing. A 45-year-old female underwent fractional CO2 laser treatment of the neck. She contacted the author for treatment of the marked erythema, swelling, and perceived skin tightness that resulted from the resurfacing procedure. Read More

Lasers Surg Med 2016 08 6;48(6):577-83. Epub 2016 Apr 6.

Goldman, Butterwick, Groff, Fabi, and Wu, Cosmetic Laser Dermatology, 9339 Genesee Avenue, Suite 300, San Diego, California, 92121.

Background And Objectives: Multi-modal combination treatments for facial rejuvenation offer the potential to achieve superior results in a single treatment session. In this study, we evaluate the safety and efficacy of combining multiple laser modalities in a single treatment session.

Methods: Fifty patients underwent a multi-modal facial laser resurfacing procedure consisting of the sequential use of 595 nm pulsed dye laser, 755 nm alexandrite laser, superficial fractionated and fully ablative CO2 laser, superficial fully ablative erbium-YAG laser, and deep fractionated ablative CO2 laser in a single treatment session. Read More

Indian J Dermatol Venereol Leprol 2016 Mar-Apr;82(2):162-8

Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Autologous platelet-rich plasma has recently attracted significant attention throughout the medical field for its wound-healing ability.

Aims: This study was conducted to investigate the potential of platelet-rich plasma combined with fractional laser therapy in the treatment of acne scarring.

Methods: Sixteen patients (12 women and 4 men) who underwent split-face therapy were analyzed in this study. Read More

J Cosmet Laser Ther 2016 Jun 8;18(3):138-48. Epub 2016 Mar 8.

a Department of Dermatology , the First Affiliated Hospital of Nanjing Medical University , Nanjing , China.

Objective: To evaluate the effects of conditioned medium of adipose-derived stem cells (ADSC-CM) on efficacy and side effects after fractional carbon dioxide laser resurfacing (FxCR) when treating subjects with facial atrophic acne scars or with skin rejuvenation needs.

Materials And Methods: Twenty-two subjects were enrolled in the study and divided into two groups. Nine subjects were included in skin rejuvenation group and thirteen subjects were included in acne scar group, and all subjects underwent three sessions of FxCR. Read More

Lasers Surg Med 2016 Mar 27;48(3):238-44. Epub 2015 Nov 27.

INSERM U1189, INSERM, 1 Avenue Oscar Lambret, Lille, France.

Background And Objective: Laser-assisted drug delivery is an emerging technology to achieve greater penetration by existing topical medications to reach desired targets in the tissue. The objective of this research was to study whether laser-assisted delivery of Vitamin C, E, and Ferulic immediately postoperatively of fractional ablative laser could improve wound healing. Secondary objectives were to evaluate the potential molecular markers involved in this wound-healing process. Read More

Indian J Dermatol 2015 Sep-Oct;60(5):473-8

Department of Biostatistics and Epidemiology, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: A number of treatments for reducing the appearance of acne scars are available, but general guidelines for optimizing acne scar treatment do not exist. The aim of this study was to compare the clinical effectiveness and side effects of fractional carbon dioxide (CO2) laser resurfacing combined with punch elevation with fractional CO2 laser resurfacing alone in the treatment of atrophic acne scars.

Materials And Methods: Forty-two Iranian subjects (age range 18-55) with Fitzpatrick skin types III to IV and moderate to severe atrophic acne scars on both cheeks received randomized split-face treatments: One side received fractional CO2 laser treatment and the other received one session of punch elevation combined with two sessions of laser fractional CO2 laser treatment, separated by an interval of 1 month. Read More

Ophthalmic Plast Reconstr Surg 2016 Jul-Aug;32(4):267-9

*Private Practice, New York, New York; †Albert Einstein College of Medicine, Bronx, New York, New York; and ‡Texas Oculoplastic Consultants, Austin, Texas, U.S.A.

Purpose: Laser resurfacing, performed at the same time as blepharoplasty, has most commonly been applied to the lower eyelid skin but can effectively be used on the upper eyelid to reduce rhytidosis and improve skin quality. The authors evaluate the safety and efficacy of this procedure.

Methods: Fractional CO2 laser resurfacing was performed in conjunction with incisional upper blepharoplasty. Read More

Lasers Med Sci 2016 Jan;31(1):9-18

Treatment of keloids (K) and hypertrophic scars (HTS) is challenging. A few case reports reported good results in HTS treated by fractional CO2 laser. The aim of the present study was the assessment of the clinical response as well as histological changes in K and HTS treated by fractional CO2 laser and the role of matrix metalloproteinase 9 (MMP9) in the response. Read More

Lasers Surg Med 2015 Dec 29;47(10):788-91. Epub 2015 Sep 29.

Division of Pediatric and Adolescent Dermatology, Rady Children's Hospital, San Diego, California.

Background And Objective: Leishmaniasis is a vector borne disease that can cause disease manifestations that range from localized skin ulceration to lethal visceral disease. With increased global travel, cutaneous leishmaniasis (CL) is becoming more common in developed nations. However, current treatment options are limited. Read More