624 results match your criteria Skin Pharmacology and Physiology[Journal]


Quantitative Analysis of Free Amino Acids and Urea Derived from Isolated Corneocytes of Healthy Young, Healthy Aged, and Diseased Skin.

Skin Pharmacol Physiol 2019 Feb 15;32(2):94-100. Epub 2019 Feb 15.

Department of Pharmaceutical Technology and Biopharmaceutics, Institute of Pharmacy, Martin Luther University of Halle-Wittenberg, Halle (Saale),

Background/aims: Free amino acids (FAAs) and urea, present inside the corneocytes, can be important indicators of skin condition. However, due to the lack of a standard extraction protocol for FAAs from corneocytes, conflicting research results have been reported. Therefore, the purpose of this study was (1) to standardize the extraction protocol and (2) to investigate FAA profiles in healthy young and healthy old volunteers, as well as in psoriasis and atopic dermatitis patients. Read More

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http://dx.doi.org/10.1159/000495992DOI Listing
February 2019

Development of a Novel Approach to Studying Corneodesmosomes and Stratum Corneum Adhesion: Extending Knowledge on the Pathophysiology of Sensitive Skin.

Skin Pharmacol Physiol 2019 Jan 23;32(2):81-93. Epub 2019 Jan 23.

Department of Dermatology, Radboud university medical center, Nijmegen, The Netherlands.

Background/aims: Aberrant skin barrier and intercorneocyte adhesion are potential contributors to the pathomechanism of sensitive skin (SS). Here we aimed to develop a novel and easy-to-apply method to analyze corneodesmosomes and to interrogate potential differences between corneocytes of subjects with SS and non-SS (NSS).

Methods: Corneocytes of the volar forearm and upper outer quadrant of the left buttock of SS (n = 10) and NSS (n = 8) subjects were extracted as a function of depth using adhesive tape and stained with anti-desmoglein 1 (DSG1) antibody. Read More

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http://dx.doi.org/10.1159/000495070DOI Listing
January 2019
1 Read

Reconstructed Human Epidermis Predicts Barrier-Improving Effects of Lactococcus lactis Emulsion in Humans.

Skin Pharmacol Physiol 2019 Jan 10;32(2):72-80. Epub 2019 Jan 10.

Institute of Pharmacy, Pharmacology and Toxicology, Freie Universität Berlin, Berlin,

Background/aims: The skin provides protection against chemical, physical, and biological stressors, yet the skin morphology changes over the course of life. These changes might affect the skin barrier function and facilitate the onset of age-related diseases. Since orally applied lactic acid bacteria ameliorate signs of aged and atopic skin, we investigated the effects of a topically applied Lactococcus lactis emulsion. Read More

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https://www.karger.com/Article/FullText/495255
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http://dx.doi.org/10.1159/000495255DOI Listing
January 2019
1 Read

Influence of Storage and Preservation Techniques on Egg-Derived Carotenoids: A Substantial Source for Cutaneous Antioxidants.

Skin Pharmacol Physiol 2019 Jan 4;32(2):65-71. Epub 2019 Jan 4.

Department of Dermatology and Venerology, State Hospital Klagenfurt, Klagenfurt,

Antioxidants like carotenoids play a major role in the prevention of the destructive influence of free radicals in our skin. Carotenoids, as well as all other antioxidants, are substantial substances which must be supplied by nutrition. Resonance Raman spectroscopy (RRS) allows measurement of the carotenoid content of eggs, representing a rich carotenoid source in our nutrition. Read More

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http://dx.doi.org/10.1159/000493147DOI Listing
January 2019
1 Read

Evaluation of Serum Paraoxonase, Arylesterase, Prolidase Activities and Oxidative Stress in Patients with Alopecia Areata.

Skin Pharmacol Physiol 2018 Dec 13;32(2):59-64. Epub 2018 Dec 13.

Private practice, Kutahya, Turkey.

Background: Alopecia areata (AA) is a disease characterized by the hair loss sharply limited in any part of the body, especially on the scalp, in circular or oval areas. The purpose of this study is to search the serum paraoxonase 1 (PON1), arylesterase and oxidative status with serum prolidase activities in people with AA.

Methods: The study included 60 AA and 50 healthy control subjects. Read More

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http://dx.doi.org/10.1159/000494690DOI Listing
December 2018
1 Read
2.366 Impact Factor

Current Data on Effects of Long-Term Missions on the International Space Station on Skin Physiological Parameters.

Skin Pharmacol Physiol 2019 28;32(1):43-51. Epub 2018 Nov 28.

DermaTronnier, Institute for Experimental Dermatology, Witten/Herdecke University, Witten, Germany.

Background: Skin reaction to spaceflight has not really been studied yet, although the skin has a very important barrier function to protect the body and can contribute to a more general understanding of physiology. It is proposed here to make a more thorough investigation of the skin during long-term spaceflight, using noninvasive techniques.

Aims: The aim of the present Skin-B study is to investigate the kinetics and range of possible skin modifications during long-duration spaceflights and their recovery. Read More

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http://dx.doi.org/10.1159/000494688DOI Listing
January 2019

Self-Reported Skin Changes by a Selected Number of Astronauts after Long-Duration Mission on ISS as Part of the Skin B Project.

Skin Pharmacol Physiol 2019 28;32(1):52-57. Epub 2018 Nov 28.

DermaTronnier, Institute for Experimental Dermatology, Witten/Herdecke University, Witten, Germany.

Background: One of the most challenging and important factors of manned space missions is to keep astronauts healthy on orbit. In a study on 46 ISS crew members who were on 6-month (average) missions, skin rashes were the most self-reported event. Furthermore, among notable events, 40% were classified as skin rashes/hypersensitivities. Read More

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http://dx.doi.org/10.1159/000494689DOI Listing
January 2019
2 Reads

ZnO:SBA-15 Nanocomposites for Potential Use in Sunscreen: Preparation, Properties, Human Skin Penetration and Toxicity.

Skin Pharmacol Physiol 2019 31;32(1):32-42. Epub 2018 Oct 31.

Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, UNIFESP, Diadema, Brazil.

Aim: We evaluated the effects of the incorporation of zinc oxide (ZnO) nanoparticles in a mesoporous matrix, aiming to improve the textural, structural and morphological properties and verify their safety so that they can be applied in sunscreen cosmetics.

Materials And Methods: ZnO nano-particles were incorporated into an ordered mesoporous silica matrix known as Santa Barbara Amorphous-15 (SBA-15), using post-synthesis methodology. The resulting nanocomposites were characterized using X-ray diffraction, small angle X-ray scattering, N2 adsorption-desorption isotherms, Fourier transform infrared spectroscopy, scanning electron microscopy and predicted in vitro sun protector factor (SPF) estimation. Read More

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http://dx.doi.org/10.1159/000491758DOI Listing
January 2019
3 Reads

In vivo Human Skin Penetration of the UV Filter Ethylhexyl Triazone: Effect of Lipid Microparticle Encapsulation.

Skin Pharmacol Physiol 2019 31;32(1):22-31. Epub 2018 Oct 31.

Background/aims: The data available on the skin permeability of ethylhexyl triazone (EHT), a widely used high-molecular-weight (823.1-Da) UV filter, are scarce and obtained only via in vitro studies. Therefore, we evaluated in vivo the penetration of EHT in human stratum corneum by the tape stripping technique. Read More

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https://www.karger.com/Article/FullText/493761
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http://dx.doi.org/10.1159/000493761DOI Listing
January 2019
4 Reads

Effect of Physical and Chemical Hair Removal Methods on Skin Barrier Function in vitro: Consequences for a Hydrophilic Model Permeant.

Skin Pharmacol Physiol 2019 19;32(1):8-21. Epub 2018 Oct 19.

Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Life Sciences, University of Vienna, Vienna, Austria.

Background: Although very common in our society, the effect of hair removal on physiological skin parameters and on the ingress of applied chemicals has not been systematically investigated. Thus, as a first step, the aim of the present study was to elucidate the effect of hair removal through epilation (electric epilation, waxing) and depilation (dry and wet shaving, depilatory cream) on skin properties in vitro using the porcine ear model.

Methods: Attenuated total reflection Fourier transform infrared spectroscopy, measurement of the transepidermal water loss (TEWL), visualization by capacitance-based contact imaging, confocal Raman spectroscopy (CRS), diffusion cell studies and tape stripping experiments were employed. Read More

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http://dx.doi.org/10.1159/000493168DOI Listing
January 2019

Moisturizers versus Current and Next-Generation Barrier Repair Therapy for the Management of Atopic Dermatitis.

Skin Pharmacol Physiol 2019 18;32(1):1-7. Epub 2018 Oct 18.

We compare here the principal characteristics of over-the-counter moisturizers with physiologic lipid-based barrier repair therapy. Moisturizers are standard ancillary therapy for anti-inflammatory skin disorders, like atopic dermatitis (AD), and can attenuate the emergence of AD, the initial step in the "atopic march." But not all moisturizers are beneficial; some can make skin function worse, and can even induce inflammation, possibly accounting for the frequent occurrence of "sensitive skin" in women. Read More

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https://www.karger.com/Article/FullText/493641
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http://dx.doi.org/10.1159/000493641DOI Listing
January 2019
1 Read

Antioxidant Properties of Ferulic Acid and Its Possible Application.

Skin Pharmacol Physiol 2018 20;31(6):332-336. Epub 2018 Sep 20.

Ferulic acid has low toxicity and possesses many physiological functions (anti-inflammatory, antioxidant, antimicrobial activity, anticancer, and antidiabetic effect). It has been widely used in the pharmaceutical, food, and cosmetics industry. Ferulic acid is a free radical scavenger, but also an inhibitor of enzymes that catalyze free radical generation and an enhancer of scavenger enzyme activity. Read More

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http://dx.doi.org/10.1159/000491755DOI Listing
November 2018
5 Reads

Novel Facial Cream Containing Carnosine Inhibits Formation of Advanced Glycation End-Products in Human Skin.

Skin Pharmacol Physiol 2018 10;31(6):324-331. Epub 2018 Sep 10.

Innovation and Development, ISDIN, Barcelona, Spain.

Background: Accumulation of advanced glycation end-products (AGEs) in skin has been associated with skin aging. Inhibition of glycation of proteins of extracellular matrix may help skin texture and appearance. The objective of the study was to demonstrate the antiglycation activity of topically applied carnosine and novel facial cream (FC) containing carnosine in human skin explants ex vivo. Read More

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https://www.karger.com/Article/FullText/492276
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http://dx.doi.org/10.1159/000492276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262686PMC
November 2018
7 Reads

Tretinoin Loaded Nanoemulsion for Acne Vulgaris: Fabrication, Physicochemical and Clinical Efficacy Assessments.

Skin Pharmacol Physiol 2018 10;31(6):316-323. Epub 2018 Sep 10.

Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.

Background And Aim: Acne vulgaris is a common inflammatory skin condition which is treated using Tretinoin (TRE), a widely used retinoid. Nano emulations (NEs) are colloidal nano-sized particles that enhance the therapeutic efficacy of TRE and minimize adverse effects. This study is aimed at developing a TRE-loaded NE (NE-TRE) and at assessing the therapeutic effects of the formulation in acne vulgaris lesions, compared to conventional 0. Read More

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http://dx.doi.org/10.1159/000488993DOI Listing
November 2018
3 Reads
2.370 Impact Factor

Application of Photoacoustic Methods and Confocal Microscopy for Monitoring of Therapeutic Response in Plaque Psoriasis.

Skin Pharmacol Physiol 2018 5;31(6):308-315. Epub 2018 Sep 5.

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Dermatology, Venerology and Allergology, Berlin, Germany.

Psoriasis is prone to relapses and requires long-term therapy that may induce a range of adverse effects; therefore, an efficient and early detection of relapses is desirable. In this study, photoacoustic imaging and confocal laser scanning microscopic (CLSM) methods were investigated for their suitability in psoriasis follow-up examinations. Using a high-resolution photoacoustic system, the vascular structures of 11 psoriatic patients and 6 healthy volunteers were investigated. Read More

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http://dx.doi.org/10.1159/000492474DOI Listing
November 2018

Influence of Relative Humidity on Electrodermal Levels and Responses.

Skin Pharmacol Physiol 2018 4;31(6):298-307. Epub 2018 Sep 4.

Department of Clinical and Biomedical Engineering, Oslo University Hospital, Oslo, Norway.

Background/aim: Electrodermal activity (EDA) is a widely used measure in psychophysiological research, and its use in wearable devices has grown in recent times. It is recommended to have proper conditions for EDA measurement, and skin hydration is one factor that has a significant influence. It is, however, not known to what extent the ambient humidity influences the recording. Read More

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http://dx.doi.org/10.1159/000492275DOI Listing
November 2018
1 Read

Age- and Diabetes-Related Changes in the Free Fatty Acid Composition of the Human Stratum Corneum.

Skin Pharmacol Physiol 2018 21;31(6):283-291. Epub 2018 Aug 21.

Institute of Pharmacy, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.

Of particular importance for Stratum corneum (SC) lipids are the free fatty acids (FFAs). Age-related changes of the SC structure lead to diminished capacity for barrier compensation. The aims of this cross-sectional study were to identify even-numbered especially odd-numbered FFAs within the intercorneocytic lamellar lipid structures of the SC and to explore age- and diabetes-related changes in FFAs. Read More

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https://www.karger.com/Article/FullText/490800
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http://dx.doi.org/10.1159/000490800DOI Listing
November 2018
13 Reads

Antidermatophytic Activity and Skin Retention of Clotrimazole Microemulsion and Microemulsion-Based Gel in Comparison to Conventional Cream.

Skin Pharmacol Physiol 2018 21;31(6):292-297. Epub 2018 Aug 21.

Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Thailand.

Aim: Antifungal activity, skin permeation and skin retention of water-in-oil microemulsion (ME) and microemulsion-based gel (MBG) containing clotrimazole (CTZ) were evaluated in comparison to a conventional CTZ cream.

Methods: CTZ-ME and CTZ-MBG containing 1% w/w of CTZ were produced. Antifungal activity against Trichophyton mentagrophytes was assessed by the agar diffusion method. Read More

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http://dx.doi.org/10.1159/000491756DOI Listing
November 2018
2 Reads

Epidermal Lamellar Granules.

Authors:
Philip Wertz

Skin Pharmacol Physiol 2018 15;31(5):262-268. Epub 2018 Aug 15.

In the mid-1950s and 1960s, transmission electron microscopes became widely available, leading to many studies of the ultrastructure of various tissues including the epidermis. Most of these studies involved tissue fixation with formaldehyde and postfixation with osmium tetroxide. A few studies employed freeze-fracture electron microscopy. Read More

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https://www.karger.com/Article/FullText/491757
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http://dx.doi.org/10.1159/000491757DOI Listing
November 2018
10 Reads

A Pilot Study to Evaluate the Effects of Topically Applied Cosmetic Creams on Epidermal Responses.

Skin Pharmacol Physiol 2018 15;31(5):269-282. Epub 2018 Aug 15.

Department of Pharmaceutical Sciences and Experimental Therapeutics, University of Iowa College of Pharmacy, Iowa City, Iowa, USA.

Application of exogenous products, such as creams, to the skin can result in subclinical changes in selected epidermal functions such as transepidermal water loss (TEWL), hydration, redness, and pH; these changes may lead to or contribute to irritation. Changes in skin surface inflammatory factors may provide further insight into this potential for irritation. The objective of this study was to evaluate the changes in epidermal properties and inflammatory mediators after 4 days of topical application of 2 different polymers formulated in cosmetic creams. Read More

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http://dx.doi.org/10.1159/000490531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112171PMC
November 2018
12 Reads

Controversy on the Use of Povidone-Iodine in Chronic Wounds.

Authors:
Franz Trautinger

Skin Pharmacol Physiol 2018 8;31(5):261. Epub 2018 Aug 8.

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https://www.karger.com/Article/FullText/491641
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http://dx.doi.org/10.1159/000491641DOI Listing
November 2018
12 Reads

Follicular Penetration of Caffeine from Topically Applied Nanoemulsion Formulations Containing Penetration Enhancers: In vitro Human Skin Studies.

Skin Pharmacol Physiol 2018 12;31(5):252-260. Epub 2018 Jul 12.

Therapeutics Research Centre, Diamantina Institute, Translational Research Institute, University of Queensland, Brisbane, Queensland, Australia.

Background/aims: This study aimed to investigate transfollicular delivery enhancement of caffeine from nanoemulsion formulations incorporating oleic acid (OA) and eucalyptol (EU) as chemical penetration enhancers.

Methods: Caffeine permeation was evaluated from nanoemulsions containing OA or EU and an aqueous control solution through excised human full-thickness skin with hair follicles opened, blocked, or left untreated. Differential tape stripping was performed, followed by cyanoacrylate skin surface biopsies to determine the amount of caffeine in the hair follicles, and skin extraction to determine the retention of caffeine in the skin. Read More

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http://dx.doi.org/10.1159/000489857DOI Listing
November 2018
2 Reads

Inflammation: A Contributor to Depressive Comorbidity in Inflammatory Skin Disease.

Skin Pharmacol Physiol 2018 28;31(5):246-251. Epub 2018 Jun 28.

Department of Medicine, University of Toronto, Women's College Hospital, Toronto, Ontario, Canada.

The prevalence of affective disorders such as depression and anxiety is particularly high in patients with autoimmune diseases, including inflammatory skin diseases such as psoriasis, atopic dermatitis, and hidradenitis suppurativa. A dysregulated immune response has been linked to the precipitation of depression in many patient populations. However, studies examining the extent to which the underlying skin disease inflammatory processes contribute to depression and a subsequent decline in quality of life are limited. Read More

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http://dx.doi.org/10.1159/000490002DOI Listing
November 2018
33 Reads

Differentiation of Different Nonmelanoma Skin Cancer Types Using OCT.

Skin Pharmacol Physiol 2018 12;31(5):238-245. Epub 2018 Jun 12.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Background: Early detection of various types of nonmelanoma skin cancer has been a challenge in dermatology. Noninvasive examination procedures such as optical coherence tomography (OCT) play an increasingly important role, besides the established gold standard of histological tissue sample analysis. OCT is a noninvasive, cross-sectional, real-time technique that allows conclusions to be drawn with regard to the presence of pathologies. Read More

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http://dx.doi.org/10.1159/000489269DOI Listing
November 2018

Basic Fibroblast Growth Factor Influences Epidermal Homeostasis of Living Skin Equivalents through Affecting Fibroblast Phenotypes and Functions.

Skin Pharmacol Physiol 2018 30;31(5):229-237. Epub 2018 May 30.

Department of Burns and Plastic Surgery, Second Affiliated Hospital, Shantou University Medical College, Shantou, China.

Aims: To elucidate the possible mechanisms of how basic fibroblast growth factor (bFGF) influences epidermal homeostasis in a living skin equivalent (LSE) model.

Methods: Several wound healing-related growth factors were analyzed at protein and mRNA levels for dermal fibroblasts of induced alpha-smooth muscle actin (α-SMA)-positive or α-SMA-negative phenotypes. During culturing an LSE model by seeding normal human keratinocytes on a fibroblast-populated type I collagen gel, bFGF or neutralizing antibody for keratinocyte growth factor (KGF) was added to investigate its effects on fibroblast phenotypes and, subsequently, epidermal homeostasis by histology and immunohistochemistry. Read More

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http://dx.doi.org/10.1159/000488992DOI Listing
November 2018
2 Reads

Hybrid Diffuse Reflectance Spectroscopy: Non-Erythemal in vivo Testing of Sun Protection Factor.

Skin Pharmacol Physiol 2018 23;31(4):220-228. Epub 2018 May 23.

Background/aims: In order to define a label sun protection factor (SPF) of topically applied sunscreens, in vivo test methods like ISO 24444, FDA guideline, or the Australian standard are used worldwide. The basis of all these methods is provoking an erythemal skin reaction by UV irradiation to find the level of unprotected and protected minimal erythemal doses (MED). In vitro methods replacing the human skin by any kind of non-human material are still not available. Read More

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http://dx.doi.org/10.1159/000488249DOI Listing
October 2018
2 Reads

Diclofenac Sodium 3% in Hyaluronic Acid 2.5% Gel Significantly Diminishes the Actinic Keratosis Area and Severity Index.

Skin Pharmacol Physiol 2018 23;31(4):206-211. Epub 2018 May 23.

CentroDerm Clinic, Wuppertal, Germany.

Background/aims: Actinic keratosis area and severity index (AKASI) is a new assessment tool to quantify the severity of actinic damage on the head. Thus far, it has not been evaluated in monitoring the efficacy of field-directed topical treatments in actinic keratosis (AK) in routine clinical practice. Thus, the aim of this study was to determine treatment outcomes by using AKASI 3 months after the initiation of topical application of diclofenac sodium 3% in hyaluronic acid 2. Read More

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http://dx.doi.org/10.1159/000488248DOI Listing
October 2018
3 Reads

Costaria costata Extract Suppresses Development of Atopic Dermatitis in chloro-2,4-dinitrobenzene-treated NC/Nga Mice.

Skin Pharmacol Physiol 2018 23;31(4):212-219. Epub 2018 May 23.

Department of Medical Nutrition, Kyung Hee University, Yongin, Republic of Korea.

We investigated the potential effects of Costaria costata (CC) on atopic dermatitis (AD) development in chloro-2,4-dinitrobenzene (DNCB)-treated NC/Nga mice. CC is a brown alga distributed across the seas of Korea, China, and Japan. A total of 40 mice were randomly assigned to 5 groups with 8 mice per group: untreated Balb/c mice, AD control (0. Read More

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http://dx.doi.org/10.1159/000487643DOI Listing
October 2018
34 Reads

Solvent-Extracted Wool Wax: Thermotropic Properties and Skin Efficacy.

Skin Pharmacol Physiol 2018 9;31(4):198-205. Epub 2018 May 9.

Department of Chemicals and Surfactant Technology, IQAC-CSIC, Barcelona, Spain.

Background/aims: Wool wax is a soft, yellow, waxy substance that is secreted by the sebaceous glands of sheep. The purpose of wool wax is to waterproof and protect the wool. Chemically, wool wax is a complex mixture of esters, fatty acids, and alcohols. Read More

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https://www.karger.com/Article/FullText/488247
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http://dx.doi.org/10.1159/000488247DOI Listing
October 2018
18 Reads

The Influence of Reactive Oxygen Species and Glucocorticoids on Dry Skin in a Mouse Model of Arthritis.

Skin Pharmacol Physiol 2018 26;31(4):188-197. Epub 2018 Apr 26.

Laboratory of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Japan.

Background: Dry skin induced by rheumatoid arthritis (RA) causes itching, which negatively influences a patient's quality of life. We previously reported that mast cells are related to dry skin in arthritic mice. However, the mechanism of mast cell activation is unclear. Read More

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http://dx.doi.org/10.1159/000488250DOI Listing
October 2018
2 Reads

Rituximab in Refractory Chronic Spontaneous Urticaria: An Encouraging Therapeutic Approach.

Skin Pharmacol Physiol 2018 12;31(4):184-187. Epub 2018 Apr 12.

Dermatology Unit, Hospital Clinic de Barcelona, Barcelona, Spain.

Background: Chronic spontaneous urticaria (CSU) is a frequent mast cell-driven disease that affects approximately 0.5-1% of the population. Antihistamines are currently the drugs of choice in patients with CSU. Read More

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http://dx.doi.org/10.1159/000487402DOI Listing
October 2018
1 Read

Skin Barrier Restoration and Moisturization Using Horse Oil-Loaded Dissolving Microneedle Patches.

Skin Pharmacol Physiol 2018 5;31(3):163-171. Epub 2018 Apr 5.

Department of Biotechnology, Yonsei University, Seoul, Republic of Korea.

Background: Horse oil (HO) has skin barrier restoration and skin-moisturizing effects. Although cream formulations have been used widely and safely, their limited penetration through the stratum corneum is a major obstacle to maximizing the cosmetic efficacy of HO. Therefore, we aimed to encapsulate HO in a cosmetic dissolving microneedle (DMN) for efficient transdermal delivery. Read More

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https://www.karger.com/Article/FullText/487401
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http://dx.doi.org/10.1159/000487401DOI Listing
September 2018
7 Reads

Topical Treatment of Skin Injury Inflicted in Mice by X-Ray Irradiation.

Skin Pharmacol Physiol 2018 4;31(4):175-183. Epub 2018 Apr 4.

Department of Pharmaceutical Technology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.

Background/aims: There is no treatment, without side effects, efficiently preventing or curing skin burns, caused by radiotherapy. A new experimental topical treatment protocol was assessed in mice receiving orthovoltage X-rays at an equivalent dose to that applied to human breast cancer patients in conventional radiotherapy.

Methods: SKH-HR2 female hairless mice were irradiated on their dorsum with a total dose of 4,300 cGy during a 1-month period (20 fractions). Read More

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https://www.karger.com/Article/FullText/487404
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http://dx.doi.org/10.1159/000487404DOI Listing
October 2018
8 Reads

Effect of Fluid Intake on Hydration Status and Skin Barrier Characteristics in Geriatric Patients: An Explorative Study.

Skin Pharmacol Physiol 2018 3;31(3):155-162. Epub 2018 Apr 3.

Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Background/aim: Inadequate fluid intake is assumed to be a trigger of water-loss dehydration, which is a major health risk in aged and geriatric populations. Thus, there is a need to search for easy to use diagnostic tests to identify dehydration. Our overall aim was to investigate whether skin barrier parameters could be used for predicting fluid intake and/or hydration status in geriatric patients. Read More

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https://www.karger.com/Article/FullText/487403
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http://dx.doi.org/10.1159/000487403DOI Listing
September 2018
8 Reads

Commentary on the "Evidence- and Consensus-Based (S3) Guidelines for the Treatment of Actinic Keratosis" Published by the International League of Dermatological Societies in Cooperation with the European Dermatology Forum.

Skin Pharmacol Physiol 2018 3;31(3):144-146. Epub 2018 Apr 3.

Department of Dermatology and Allergology, Clinic Vest, Recklinghausen, Germany.

In 2015, the International League of Dermatological Societies and the European Dermatology Forum published a guideline for the treatment of actinic keratosis, which is classified as an evidence- and consensus-based S3 guideline. From the point of view of the GD Task Force "Licht.Hautkrebs. Read More

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http://dx.doi.org/10.1159/000486687DOI Listing
September 2018
8 Reads

Dermocosmetics for Use in Rosacea: Guideline of the Society for Dermopharmacy.

Skin Pharmacol Physiol 2018 29;31(3):147-154. Epub 2018 Mar 29.

Department of Dermatology and Allergology, Ludwig-Maximilians University, Munich, Germany.

Rosacea is a widespread inflammatory skin disease that is chronically recurrent and affects predominately the central parts of the face. Affected individuals typically react to numerous cosmetics with redness, burning, and/or worsening of the complexion. Consequently, there is a high demand for dermocosmetics that do not provoke such reactions and are suitable for use in rosacea. Read More

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https://www.karger.com/Article/FullText/486688
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http://dx.doi.org/10.1159/000486688DOI Listing
September 2018
6 Reads

Punicalagin and (-)-Epigallocatechin-3-Gallate Rescue Cell Viability and Attenuate Inflammatory Responses of Human Epidermal Keratinocytes Exposed to Airborne Particulate Matter PM10.

Skin Pharmacol Physiol 2018 22;31(3):134-143. Epub 2018 Mar 22.

Department of Molecular Medicine, Cell and Matrix Research Institute, BK21 Plus KNU Biomedical Convergence Program, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.

Background/aims: Airborne particulate matter with a diameter of < 10 µm (PM10) causes oxidative damage, inflammation, and premature skin aging. In this study, we evaluated whether polyphenolic antioxidants attenuate the inflammatory responses of PM10-exposed keratinocytes.

Methods: Primary human epidermal keratinocytes were exposed in vitro to PM10 in the absence or presence of punicalagin and (-)-epigallocatechin-3-gallate (EGCG), which are the major polyphenolic antioxidants found in pomegranate and green tea, respectively. Read More

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https://www.karger.com/Article/FullText/487400
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http://dx.doi.org/10.1159/000487400DOI Listing
September 2018
32 Reads

Effects of Short-Term Moisturizer Application in Different Ethnic Skin Types: Noninvasive Assessment with Optical Coherence Tomography and Reflectance Confocal Microscopy.

Skin Pharmacol Physiol 2018 14;31(3):125-133. Epub 2018 Mar 14.

Background/aims: Ethnic skin types are known to differ in their morphological and physiological features. Thus, treatment responses may vary among different races. We aimed to assess skin morphology of different ethnicities and to compare the effect of short-term moisturizer application using optical coherence tomography (OCT) and reflectance confocal microscopy (RCM). Read More

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http://dx.doi.org/10.1159/000486626DOI Listing
September 2018
5 Reads

Physiological and Molecular Effects of in vivo and ex vivo Mild Skin Barrier Disruption.

Skin Pharmacol Physiol 2018 7;31(3):115-124. Epub 2018 Mar 7.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy, Berlin, Germany.

The success of topically applied treatments on skin relies on the efficacy of skin penetration. In order to increase particle or product penetration, mild skin barrier disruption methods can be used. We previously described cyanoacrylate skin surface stripping as an efficient method to open hair follicles, enhance particle penetration, and activate Langerhans cells. Read More

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http://dx.doi.org/10.1159/000484443DOI Listing
September 2018
2 Reads

Sesquiterpene-Enriched Extract of Curcuma aeruginosa Roxb. Retards Axillary Hair Growth: A Randomised, Placebo-Controlled, Double-Blind Study.

Skin Pharmacol Physiol 2018 9;31(2):99-106. Epub 2018 Feb 9.

Bioscreening Unit, Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok, Thailand.

Background: Sesquiterpenes in Curcuma aeruginosa Roxb. inhibit steroid 5α-reductase and dihydrotestosterone production, and reverse androgenic alopecia. This study sought to show that a high sesquiterpene C. Read More

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http://dx.doi.org/10.1159/000486136DOI Listing
August 2018
6 Reads

A Time-Series Study of the Effect of Air Pollution on Outpatient Visits for Acne Vulgaris in Beijing.

Skin Pharmacol Physiol 2018 7;31(2):107-113. Epub 2018 Feb 7.

Department of Dermatology, The General Hospital of Air Force, Beijing, China.

Background/aims: There is increasing evidence that exposure to air pollutants, including particulate matter (PM2.5, PM10), nitrogen dioxide (NO2), and sulfur dioxide (SO2), might aggravate preexisting skin diseases such as eczema and urticaria. Here we investigated if a possible link exists between air pollution and acne vulgaris. Read More

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http://dx.doi.org/10.1159/000484482DOI Listing
August 2018
4 Reads

New Hydrogels Enriched with Antioxidants from Saffron Crocus Can Find Applications in Wound Treatment and/or Beautification.

Skin Pharmacol Physiol 2018 1;31(2):95-98. Epub 2018 Feb 1.

Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.

Saffron extracts have a long history of application as skin protectant, possibly due to their ability to scavenge free radicals. In this work, the performance of a hydrogel enriched with antioxidant compounds isolated from saffron crocus (Crocus sativus L.) petals was tested. Read More

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http://dx.doi.org/10.1159/000486135DOI Listing
August 2018
5 Reads

Laser Scanning Microscopic Investigations of the Decontamination of Soot Nanoparticles from the Skin.

Skin Pharmacol Physiol 2018 20;31(2):87-94. Epub 2018 Jan 20.

Center of Experimental and Applied Cutaneous Physiology (CCP), Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Background/aims: Airborne pollutants, such as nano-sized soot particles, are increasingly being released into the environment as a result of growing population densities and industrialization. They can absorb organic and metal compounds with potential biological activity, such as polycyclic aromatic hydrocarbons and airborne pollen allergens. Local and systemic toxicities may be induced in the skin if the particulates release their harmful components upon dermal contact. Read More

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http://dx.doi.org/10.1159/000485900DOI Listing
August 2018
4 Reads

Vitamin D and the Pathophysiology of Inflammatory Skin Diseases.

Skin Pharmacol Physiol 2018 6;31(2):74-86. Epub 2018 Jan 6.

Research Department, Division of Translational Medicine, Sidra Medicine, Doha, Qatar.

Background: Vitamin D is a secosteroid, which was initially known for its skeletal role; however, in recent years, its functions in different organs have been increasingly recognized. In this review, we will provide an overview of vitamin D functions in the skin physiology with specific focus on its role in certain inflammatory skin conditions such as psoriasis and atopic dermatitis.

Methods: A comprehensive literature search was carried out in PubMed and Google Scholar databases using keywords like "vitamin D," "skin," "atopic dermatitis," and "psoriasis. Read More

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https://www.karger.com/Article/FullText/485132
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http://dx.doi.org/10.1159/000485132DOI Listing
August 2018
17 Reads

Neoplastic Multifocal Skin Lesions: Biology, Etiology, and Targeted Therapies for Nonmelanoma Skin Cancers.

Skin Pharmacol Physiol 2018 21;31(2):59-73. Epub 2017 Dec 21.

Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Coimbra, Portugal.

Neoplastic skin lesions are multifocal, diffuse skin infiltrations of particular relevance in the differential diagnosis of ulcerative, nodular, or crusting skin lesions. Nonmelanoma skin cancers (NMSCs), namely, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and also actinic keratosis (AK), are the most common malignant tumors in humans. BCCs do not proliferate rapidly and most of the times do not metastasize, while SCCs are more infiltrative, metastatic, and destructive. Read More

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http://dx.doi.org/10.1159/000479529DOI Listing
August 2018
15 Reads

Consensus on Wound Antisepsis: Update 2018.

Skin Pharmacol Physiol 2018 21;31(1):28-58. Epub 2017 Dec 21.

Institute of Hygiene and Environmental Medicine, University Medicine Greifswald, Greifswald, Germany.

Wound antisepsis has undergone a renaissance due to the introduction of highly effective wound-compatible antimicrobial agents and the spread of multidrug-resistant organisms (MDROs). However, a strict indication must be set for the application of these agents. An infected or critically colonized wound must be treated antiseptically. Read More

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https://www.karger.com/Article/FullText/481545
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http://dx.doi.org/10.1159/000481545DOI Listing
August 2018
36 Reads

Editorial.

Authors:

Skin Pharmacol Physiol 2017 9;30(6). Epub 2017 Dec 9.

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http://dx.doi.org/10.1159/000485353DOI Listing
October 2018
4 Reads

Capsaicin Used on Skin Influences Ion Transport Pathways: An in vitro Study.

Skin Pharmacol Physiol 2018 8;31(1):19-27. Epub 2017 Nov 8.

Department of Pathobiochemistry and Clinical Chemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Torun, Bydgoszcz, Poland.

Acute, adverse skin effects to capsaicin can be activated by inhibition of sodium transport not only in nociceptive neurons, but also in keratinocytes. The aim of the current study was to describe and compare immediate (15 s) and prolonged (30 min) effects of capsaicin on epidermal (not neural) sodium transport using a rabbit skin model. Skin fragments (n = 169) were incubated in 4 conditions: undisturbed ion transport (U; n = 48); inhibited sodium transport (INa; n = 34) with amiloride used as sodium transport blocker; long-term irritation by capsaicin with undisturbed ion transport (CAPSA-U; n = 43) and with inhibited sodium transport (CAPSA-INa; n = 35). Read More

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http://dx.doi.org/10.1159/000481689DOI Listing
August 2018
39 Reads

Pleiotropic Effects of White Willow Bark and 1,2-Decanediol on Human Adult Keratinocytes.

Skin Pharmacol Physiol 2018 8;31(1):10-18. Epub 2017 Nov 8.

Department of Life Sciences and Systems Biology, University of Turin, Turin, Italy.

Background: Acne vulgaris is a common skin defect, usually occurring during adolescence, but often it can persist in adults leaving permanent face scarring. Acne is usually treated with topical drugs, oral antibiotics, retinoids, and hormonal therapies, but medicinal plants are increasingly employed.

Objective: To investigate the protective role of white willow bark (WWB) and 1,2-decanediol (DD) on the damage caused by lipopolysaccharides (LPS) on human adult keratinocytes (HaCaT). Read More

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http://dx.doi.org/10.1159/000481690DOI Listing
August 2018
3 Reads

The Prevalence of Periodontitis Is Increased in Psoriasis and Linked to Its Inverse Subtype.

Skin Pharmacol Physiol 2017 2;30(6):324-328. Epub 2017 Nov 2.

Department of Dermatology, Medical University of Graz, Graz, Austria.

Periodontitis and psoriasis are suggested to be co-occurring, chronic inflammatory conditions with overlapping characteristics. However, respective evidence is rare and data on risk factors of periodontitis in psoriasis patients are minimal. The aim of this study was to expand the evidence of psoriasis-associated periodontitis and establish a potential risk profile for periodontitis. Read More

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http://dx.doi.org/10.1159/000481544DOI Listing
October 2018
4 Reads