753,835 results match your criteria Skin Pharmacology and Physiology[Journal]


Donor T-cell-derived interleukin-22 promotes thymus regeneration and alleviates chronic graft-versus-host disease in murine allogeneic hematopoietic cell transplant.

Int Immunopharmacol 2018 Dec 14;67:194-201. Epub 2018 Dec 14.

Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China; Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou Medical University, Xuzhou, China. Electronic address:

Defect of thymus results in poor posttransplant immune recovery and dysfunction of immune tolerance after allogeneic hematopoietic cell transplants (allo-HCT). Improving thymus regeneration represents a potential strategy to accelerate recovery of T-cell immunity. IL-22 was reported to mediate thymus regeneration after injury. Read More

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December 2018
1 Read

Comparison of International Systemic Adverse Reactions due to Allergen Immunotherapy.

J Allergy Clin Immunol Pract 2018 Dec 14. Epub 2018 Dec 14.

Section of Allergy and Clinical Immunology, Imperial College London, National Heart and Lung Institute, Royal Brompton Hospital, London, UK.

Background: Several classifications of systemic adverse reactions (SAR) during allergen immunotherapy (AIT) have been proposed but the comparison of their usefulness in daily clinical practice is lacking.

Objective: The present post hoc analysis was aimed to investigate the practicality of the most relevant international classifications proposed by the European Academy of Allergology and Clinical Immunology (EAACI), the American Academy of Asthma, Allergology and Clinical Immunology /American College of Allergy, Asthma and Immunology (AAAACI/ACAAI), and the World Allergy Organization (WAO) using data provided by the longitudinal European Survey on Adverse Systemic Reactions in Allergen Immunotherapy (EASSI) based on daily clinical practice in 3 countries in Europe.

Methods: One hundred and nine SAR over 4363 AIT courses were classified as mild (n=78, 71. Read More

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December 2018
1 Read

Immediate Hypersensitivity to Polyethylene Glycols and Polysorbates: More Common Than We Have Recognized.

J Allergy Clin Immunol Pract 2018 Dec 14. Epub 2018 Dec 14.

Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Background: The most common immediate hypersensitivity to macrogols is associated with PEG 3350, however the epidemiology, mechanisms and cross-reactivity are poorly understood. Thousands of medications contain either PEGs or structurally similar polysorbates.

Objective: Our objective was to better understand the mechanism, cross-reactivity and scope of PEG hypersensitivity. Read More

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December 2018
2 Reads

Dissolvable microneedle patch containing doxorubicin and docetaxel is effective in 4T1 xenografted breast cancer mouse model.

Int J Pharm 2018 Dec 14. Epub 2018 Dec 14.

Department of Pharmacy, Birla Institute of Technology and Science (BITS) Pilani, Hyderabad Campus, Hyderabad 500078, Telangana, India. Electronic address:

Microneedle-devices provide a promising alternative to syringe-injection-based administration of chemotherapeutics. Dissolvable polymeric microneedles provide possibility of carrying greater payload and dual drugs. Here, we report development of polyvinyl pyrrolidone and polyvinyl alcohol composite dissolvable polymeric microneedle system for co-delivery of doxorubicin HCl and docetaxel. Read More

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December 2018
1 Read

Active edible films of methylcellulose with extracts of green apple (Granny Smith) skin.

Int J Biol Macromol 2018 Dec 14. Epub 2018 Dec 14.

Centro de Investigación y Desarrollo en Criotecnología de Alimentos (CIDCA)-CONICET, CIC, Facultad de Ciencias Exactas - UNLP, 47 y 116, La Plata 1900, Argentina. Electronic address:

The aim a present study was developed methylcellulose (MC) active edible films with extracts of green apple skin, as model systems of edible coating. Active edible films were developed by incorporation of ethanolic extract of freeze-dried apple skin (EEFD) and aqueous extract of apple skin (AES) at 10, 20 and 25% (v/v) concentrations. Analysis of thermal, mechanical and functional properties was carried out. Read More

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December 2018
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IgE blockade in autoimmunity: Omalizumab induced remission of bullous pemphigoid.

Clin Immunol 2018 Dec 14. Epub 2018 Dec 14.

Department of Clinical Immunology, Royal Perth Hospital, Perth, WA 6000, Australia; Institute of Immunology and Infectious Diseases (IIID), Murdoch University, Murdoch, WA 6150, Australia. Electronic address:

Bullous pemphigoid (BP) is a blistering dermopathy and a prototypic antibody-mediated autoimmune disease. Detection of IgG autoantibodies against hemidesmosomal proteins BP180 and/or BP230 are diagnostic and levels can correlate with disease activity. Therapies include corticosteroids and oral immunosuppressants, while intravenous immunoglobulin and rituximab are reserved for treatment resistant cases. Read More

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December 2018
3 Reads

Is it possible to combine photodynamic therapy and application of dinitrosyl iron complexes in the wound treatment?

Nitric Oxide 2018 Dec 14. Epub 2018 Dec 14.

Department of Polymers and Composites, N.N.Semenov Institute of Chemical Physics, RAS, 4 Kosygin St., Moscow, 119991, Russia; Institute for Regenerative Medicine, Sechenov University, 8-2 Trubetskaya St., Moscow, 119991, Russia; Institute of Photonic Technologies, Research Center "Crystallography and Photonics", RAS, 2 Pionerskaya st., Troitsk, Moscow, 142190, Russia.

We have studied the effect of interactions between dinitrosyl iron complexes with thiol-containing ligands (DNIC-TL) and diglucamine salt of chlorine e6 (photoditazine, PD) on the rate of photosensitized oxidation of a model organic substrate - tryptophan - in the presence and absence of an amphiphilic polymer, Pluronic F127, as well as on the DNIC-TL and PD photostability. Using EPR and UV spectroscopy, we determined the rate constants for photodegradation of mono- and dinuclear DNIC-TL and PD, respectively. The presence of the photosensitizer and Pluronic F127 has been shown to have a negligible effect on the rate of photodestruction of mono- and dinuclear DNIC-TL, taking into account the changing DNIC-TL and PD concentrations in the photoexcitation conditions. Read More

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December 2018
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Molecular cloning and expression analysis of coagulation factor VIII and plasminogen involved in immune response to GCRV, and immunity activity comparison of grass carp Ctenopharyngodon idella with different viral resistance.

Fish Shellfish Immunol 2018 Dec 14. Epub 2018 Dec 14.

Hunan Engineering Technology Research Center of Featured Aquatic Resources Utilization, Hunan Agricultural University, Changsha, 410128, China; Collaborative Innovation Center for Efficient and Health Production of Fisheries in Hunan Province, Changde, Hunan, 415000, China. Electronic address:

The grass carp reovirus (GCRV) has been shown to cause lethal infections in the grass carp Ctenopharyngodon idella (C. idella). In order to investigate the immune response to GCRV infection, the full-length cDNA sequences of coagulation factor VIII (CiFVIII) and plasminogen (CiPLG) from C. Read More

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December 2018
1 Read

Mast Cell Granules: Modulating adaptive immune response remotely.

J Allergy Clin Immunol 2018 Dec 14. Epub 2018 Dec 14.

Immune Imaging Program Centenary Institute, Faculty of Medicine and Health The University of Sydney, Camperdown, NSW 2050, Australia; Discipline of Dermatology, Faculty of Medicine and Health University of Sydney, NSW 2006, Australia; Department of Dermatology, Medical University of Vienna, Vienna 1090, Austria.

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December 2018
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A pedicled split extended vertical deep inferior epigastric (s-vDIEP) flap and an adipo-dermal thigh local flap for the reconstruction of the medial thigh compartment after sarcoma resection: A case report.

Microsurgery 2018 Dec 17. Epub 2018 Dec 17.

Department of Plastic and Hand Surgery, University Hospital Zurich, Zurich, Switzerland.

Large upper medial thigh defects in prior irradiated tissue require challenging reconstructions. Several techniques have been reported to reconstruct this region and according to the literature, pedicled perforator flaps are the first reconstructive option. The anterolateral thigh flap is considered the gold standard, while surprisingly the pedicle deep inferior epigastric (DIEP) flap in vertical fashion has not been frequently employed, if compared with its muscular counterpart, the pedicle vertical rectus abdomins flap (vRAM). Read More

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December 2018
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Genome wide association study to identify predictors for severe skin toxicity in colorectal cancer patients treated with cetuximab.

PLoS One 2018 17;13(12):e0208080. Epub 2018 Dec 17.

Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands.

EGFR-antibodies are associated with significant skin toxicity, including acneiform rash and folliculitis. It remains impossible to predict the occurrence of severe skin toxicity due to the lack of predictive markers. Here, we present the first genome-wide association study (GWAS) to find single nucleotide polymorphisms (SNPs) associated with EGFR inhibitor-induced skin toxicity using data of the multicentre randomized phase III CAIRO2 trial (clinicaltrials. Read More

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December 2018
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Characterization of T cell receptors in a novel murine model of nickel-induced intraoral metal contact allergy.

PLoS One 2018 17;13(12):e0209248. Epub 2018 Dec 17.

Department of Clinical Immunology, Clinical Research Center for Rheumatology and Allergy, Sagamihara National Hospital, National Hospital Organization, Sagamihara, Japan.

Nickel is a component of several alloy types that are widely used in our environment, including several dental alloy types that cause intraoral metal contact allergy. However, metal-specific immune responses in the oral mucosa have not been elucidated because a suitable animal model has not been established. In this study, we established a novel murine model of nickel-induced intraoral metal contact allergy and aimed to elucidate the immune response in terms of T-cell receptor repertoire and cytokine profiles in inflamed oral mucosa. Read More

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December 2018
2 Reads

Acanthamoeba profilin elicits allergic airway inflammation in mice.

PLoS Negl Trop Dis 2018 Dec 17;12(12):e0006979. Epub 2018 Dec 17.

Department of Parasitology School of Medicine, Pusan National University, Yangsan, Gyeongsangnam-do, South Korea.

Background: In previous studies, we suggested that Acanthamoeba is a new aero-allergen and that patients who showed positive results for the skin-prick test response to Acanthamoeba cross-reacted with several pollen allergens. Additionally, patients with common antibodies reacted to the 13-15 kDa Acanthamoeba unknown allergen.

Objective: We examined whether profilin of Acanthamoeba is a human airway allergic agent because of its molecular weight. Read More

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December 2018
1 Read

Widespread circulation of West Nile virus, but not Zika virus in southern Iran.

PLoS Negl Trop Dis 2018 Dec 17;12(12):e0007022. Epub 2018 Dec 17.

Department of Clinical Virology, Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Namazi Hospital, Shiraz, Iran.

West Nile virus (WNV) and Zika virus (ZIKV) are mosquito-borne viral infections. Over the past few decades, WNV has been associated with several outbreaks involving high numbers of neuroinvasive diseases among humans. The recent re-emergence of ZIKV has been associated with congenital malformation and also with Guillain-Barre syndrome in adults. Read More

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December 2018
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Chemical predator signals induce metabolic suppression in rock goby (Gobius paganellus).

PLoS One 2018 17;13(12):e0209286. Epub 2018 Dec 17.

Leibniz Centre for Tropical Marine Research (ZMT), Bremen, Germany.

In nature, a multitude of both abiotic and biotic stressors influence organisms with regard to their overall fitness. Stress responses that finally impair normal biological functions may ultimately result in consequences for whole populations. This study focused on the metabolic response of the intertidal rock pool fish Gobius paganellus towards simulated predation risk. Read More

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December 2018
2 Reads

Correlation of serum tryptase levels with total number of nevi, Breslow thickness, ulceration, and mitotic index in melanoma patients: evaluation of a promising prognostic marker.

Melanoma Res 2018 Dec 15. Epub 2018 Dec 15.

Dermatologic Clinic, Departement of Internal Medicine and Medical Specialties, La Sapienza University of Rome.

Current evidences suggest that mast cells contribute to the proliferation and differentiation of skin melanocytes. According to these findings, we carried out an observational cross-sectional study to investigate the correlation between the total number of nevi (TN), Breslow thickness (BT), and serum tryptase (ST) levels in a cohort of 35 melanoma (MM) patients. A Mann-Whitney test was performed to compare ST values within each variable. Read More

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December 2018
1 Read

Quantifying Burn Injury-Related Disability and Quality of Life in the Developing World: A Primer for Patient-Centered Resource Allocation.

Ann Plast Surg 2018 Dec 13. Epub 2018 Dec 13.

From the Department of Plastic Surgery, The University of Virginia, Charlottesville, VA.

Background: Untreated or undertreated burns are commonly encountered by plastic surgeons on medical trips in India and represent a major cause of disability. We sought to utilize validated patient-reported outcomes instruments to identify the patient population with the greatest burn-related disability in order to appropriately allocate plastic surgery resources to those in greatest need.

Methods: The Quick Disability of the Arm, Shoulder, and Hand, RAND 36-Item Short Form Health Survey, and Burn-Specific Health Scale-Revised, Brief, and Adapted questionnaires were administered via an interpreter during a plastic surgery trip to Jharkhand, India, in January 2018. Read More

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December 2018
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Abnormal Presentation of Aggressive Fibromatosis After Radiotherapy for Keloids: Case Report and Brief Literature Review.

Ann Plast Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Burn and Plastic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Rationale: Keloids, dermal fibroproliferative lesions, often occur secondary to skin injury and extend beyond the margins of the original lesion. Aggressive fibromatosis (AF) is a rare condition arising from fibroblasts and is characterized clinically as a nonmetastasizing but locally invasive tumor. In this work, we present the case of a patient who developed AF in the chest 3 years after surgery and postoperative radiotherapy for keloids. Read More

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December 2018
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Modified V-Y Fasciocutaneous Flap Reconstruction After Abdominoperineal Resection in Irradiated Patients Prevents Wound Dehiscence and Associated Complications: A Retrospective Analysis and Benchtop Confirmation.

Ann Plast Surg 2018 Dec 13. Epub 2018 Dec 13.

Division of Plastic and Reconstructive Surgery, Duke University Medical Center, Durham NC.

Background: Primary perineal closure following abdominal perineal resection (APR) is reported to have a wound complication rate as high as 66%, whereas flap reconstruction reduces wound complications to 15% to 35%. A modified de-epithelialized V-Y fasciocutaneous flap aims to further improve results in this patient population.

Methods: To study the breaking force of a simple interrupted suture in either skin or subcutaneous fat, various quantitative assessments were performed in a porcine flap model using uniaxial static tensile testing with an Instron tensiometer, with a single or triple row of 3 Vicryl sutures in both skin and fat. Read More

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December 2018
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Optimal Result of One-Stage Secondary Debulking Procedure After Flap Reconstruction of the Ankle.

Ann Plast Surg 2018 Dec 13. Epub 2018 Dec 13.

From the Department of Plastic and Reconstructive Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Skin and soft tissue defect of the ankle usually mandates flap reconstruction; however, bulky flap and difficulty ambulance have been the major disadvantages after flap reconstruction of this area. We used the concept of full-thickness skin graft as a 1-stage method of secondary debulking procedure to achieve both aesthetic and functional results.

Methods: Since January of 2004 to June of 2016, 22 one-stage secondary debulking procedures were performed on 22 patients who had received reconstruction with flaps for ankle defects. Read More

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December 2018
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Ixekizumab improves patient-reported outcomes in patients with active psoriatic arthritis and inadequate response to tumour necrosis factor inhibitors: SPIRIT-P2 results to 52 weeks.

Clin Exp Rheumatol 2018 Nov 19. Epub 2018 Nov 19.

Department of Medicine, Rheumatology Research Unit, University of Queensland, Sunshine Coast, QLD, Australia.

Objectives: To report patient-reported outcomes (PROs) of ixekizumab-treated patients with psoriatic arthritis (PsA) and an inadequate response (IR) or intolerance to tumour necrosis factor inhibitors (TNFi) to 52 weeks.

Methods: In SPIRIT-P2, patients with active PsA and an IR or intolerance to TNFi were randomised to ixekizumab 80 mg every 4 weeks (IXEQ4W; N=122) or every 2 weeks (IXEQ2W; N=123), or placebo (PBO; N=118) during the initial 24-week double-blind treatment period. At Week 16, background therapy was modified for IRs; additionally, IRs in the placebo group were re-randomised (1:1) to IXEQ2W or IXEQ4W. Read More

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November 2018
2 Reads

Skin Integrity and Infection Prevention Las Vegas: transform uncertainty into quality wound healing.

Authors:

J Wound Care 2018 Dec;27(12):860-861

The 4th International Skin Integrity and Infection Prevention conference, in hosted by the Journal of Wound Care and the University of Huddersfield, was held in Las Vegas. The last in our series of reports, which describe the key points discussed at the sponsored symposia, looked at wound bed preparation, concentrating on debriding a wound using a surfactant gel when sharp debridement is not an option. Read More

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December 2018
1 Read

Photodynamic therapy in infected venous and mixed leg ulcers: a pilot experience.

J Wound Care 2018 Dec;27(12):816-821

Consultant, Angiology Department, MD Barbantini Clinic, Lucca, Italy.

Objective:: To assess the tolerability and efficacy of photodynamic therapy (PDT) with RLP068, a novel phthalocyanine-derived photosensitiser, in controlling the bacterial load in different leg ulcers, due to vascular pathophysiology.

Method:: An observational study of patients with infected leg ulcers of different pathophysiology, admitted to the hospital for a skin grafting procedure, were included. All patients underwent two sessions of PDT at time zero and after 72 hours. Read More

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December 2018
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Skin Integrity and Infection Prevention Las Vegas: continuous delivery of oxygen enhances closure of diabetic foot ulcers.

Authors:

J Wound Care 2018 Dec;27(12):856-857

The 4th International Skin Integrity and Infection Prevention conference, hosted by the Journal of Wound Care and the University of Huddersfield in Las Vegas, included a series of sponsored symposia. This is the third in our series of reports on the key points of the symposia, which outlined the effects of hypoxia on wound healing, and how reduced oxygen levels can lead to chronic, non-healing wounds. The speaker, Mark Niederauer, explained what can be done to combat low oxygen levels using a new continuous diffusion of oxygen (CDO) device. Read More

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December 2018
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A new unilateral abduction orthosis for Ponseti-treated clubfoot: A cohort study to assess compliance.

Prosthet Orthot Int 2018 Dec 17:309364618814866. Epub 2018 Dec 17.

2 Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust, Oswestry, UK.

Background:: The Ponseti method for treating congenital talipes equinovarus requires an orthosis to maintain correction after manipulation and casting, typically the 'boots and bar'. Non-compliance with the orthosis increases the risk of recurrent deformity. This study investigates a new orthosis, the abduction dorsiflexion mechanism. Read More

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December 2018
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Behcet's Disease in Iran; Analysis of 7641 Cases.

Mod Rheumatol 2018 Dec 17:1-21. Epub 2018 Dec 17.

a Behcet's Disease Unit, Rheumatology Research Center , Shariati Hospital, Tehran University of Medical Sciences , Tehran , Iran.

Objective: To analyze Behcet's Disease (BD) in Iran, from 1975 to 2018, and compare to 35 large/small reports from other countries.

Methods: Patients from all over Iran, when suspected, were sent to the BD Unit. The diagnosis was done by expert opinion. Read More

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December 2018
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Relative antigenicity of components in vascularized composite allotransplants: An experimental study of microRNAs expression in rat hind limb transplantation model.

Microsurgery 2018 Dec 17. Epub 2018 Dec 17.

Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background: Skin is considered to be the most antigenic component of all vascularized composite allotransplantation tissues. However, no studies have used methods other than histological assessment to analyze the relative antigenicity of various components. In this study, we analyzed gene expression to investigate the relative antigenicity of each component in the transplanted limb. Read More

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December 2018
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Systemic Tofacitinib Concentrations in Adult Patients With Atopic Dermatitis Treated With 2% Tofacitinib Ointment and Application to Pediatric Study Planning.

J Clin Pharmacol 2018 Dec 17. Epub 2018 Dec 17.

Pfizer Inc., Groton, CT, USA.

Atopic dermatitis is a chronic eczematous, pruritic, inflammatory skin condition affecting children and adults. Tofacitinib is a Janus kinase inhibitor. The efficacy, safety, and pharmacokinetics of 2% tofacitinib ointment twice daily have been evaluated in a 4-week phase 2a multisite randomized, double-blind, vehicle-controlled, parallel-group study (NCT02001181) in adult patients with mild to moderate atopic dermatitis and 2% to 20% body surface area (BSA) involvement. Read More

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December 2018
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Preparation and properties of cellulose nanocrystals, gelatin, hyaluronic acid composite hydrogel as wound dressing.

J Biomater Sci Polym Ed 2018 Dec 17:1-27. Epub 2018 Dec 17.

c Second Department of Oncology, Linyi People's Hospital , Linyi 276003 , China.

Gelatin (GA), hyaluronic acid (HA) and cellulose nanocrystals (CNC) are promising materials for skin wound care. In this study the GA-HA-CNC hydrogels were prepared by cross-linking and freeze-drying. The composition and mechanism of GA-HA-CNC hydrogels were confirmed by FTIR. Read More

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December 2018
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UCP2 Overexpression Redirects Glucose into Anabolic Metabolic Pathways.

Proteomics 2018 Dec 17:e1800353. Epub 2018 Dec 17.

Department of Pharmacology, Toxicology & Neuroscience, LSU Health Sciences Center, Shreveport, LA, 71130.

Uncoupling protein 2 (UCP2) is often upregulated in cancer cells. The UCP2 upregulation is positively correlated with enhanced proliferation, tumorigenesis, and metabolic alterations, thus suggesting that UCP2 upregulation could play a key role in sensing metabolic changes to promote tumorigenesis. To determine the global metabolic impact of UCP2 upregulation, we used C glucose as a source molecule to 'trace' the metabolic fate of carbon atoms derived from glucose. Read More

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December 2018
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Description and characterization of a hair coat disorder in schipperkes.

Vet Dermatol 2018 Dec 17. Epub 2018 Dec 17.

Department of Biomedical and Diagnostic Sciences, UT College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN, 37996, USA.

Background: Schipperkes develop bilaterally symmetrical alopecia preceded by lightening of the hair coat not associated with systemic clinical signs. The alopecia is presumptively diagnosed as Alopecia X but has never been investigated.

Hypothesis/objectives: The purpose of this study was to describe clinical features, histopathological and laboratory abnormalities associated with symmetrical, noninflammatory alopecia in schipperkes. Read More

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December 2018
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Quantitative susceptibility mapping detects neovascularization of the epiphyseal cartilage after ischemic injury in a piglet model of legg-calvé-perthes disease.

J Magn Reson Imaging 2018 Dec 17. Epub 2018 Dec 17.

Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, USA.

Background: Legg-Calvé-Perthes disease (LCPD) is a childhood hip disorder thought to be caused by disruption of blood supply to the developing femoral head. There is potential for imaging to help assess revascularization of the femoral head.

Purpose: To investigate whether quantitative susceptibility mapping (QSM) can detect neovascularization in the epiphyseal cartilage following ischemic injury to the developing femoral head. Read More

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December 2018
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Relationship between sick building syndrome and indoor air quality among hospital staff.

Med Lav 2018 Dec 20;109(6):435-443. Epub 2018 Dec 20.

Medicine Faculty of Dumlupinar University, Department of Public Health.

Background: Sick building syndrome (SBS) is defined as a condition occurring in those who live or work in a modern building and who suffer from symptoms such as headache, fatigue, lack of concentration and irritation of the skin and mucous membranes.

Objectives: The aim of this study was to evaluate the relationship between personal characteristics, environmental factors and the prevalence of SBS among the secretaries working in a hospital.

Method: In this cross-sectional study, questionnaires were administered to all secretaries who were working in Kutahya hospital in January and March 2018. Read More

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December 2018
1 Read

Nanomedicine Advances in Topical Infective and Non-Infective Skin Diseases Therapy.

Recent Pat Antiinfect Drug Discov 2018 ;13(2):104

University Institute of Pharmaceutical Sciences (UIPS), Panjab University, Chandigarh, India.

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January 2018
1 Read

Margin-Controlled, Staged Surgical Excision in the Treatment of High-Risk Basal Cell Carcinomas of the Head and Neck Region.

J Cutan Med Surg 2018 Dec 17:1203475418820868. Epub 2018 Dec 17.

2 Department of Plastic Reconstructive and Aesthetic Surgery, Marmara University School of Medicine, Istanbul, Turkey.

Background:: The most common skin cancer is basal cell carcinoma (BCC), and the gold-standard treatment for high-risk tumours is Mohs surgery. However, alternative methods are needed for high-risk tumours in countries where the performance rate of Mohs surgery is low.

Objectives:: The objective of this article is to investigate the feasibility, efficacy, and safety of margin-controlled, staged surgical excision (MCSSE) in high-risk tumours as a possible treatment alternative. Read More

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December 2018
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Distinction of Condylomata Acuminata from Vulvar Vestibular Papules or Pearly Penile Papules Using Ki-67 Immunostaining.

J Cutan Med Surg 2018 Dec 17:1203475418819992. Epub 2018 Dec 17.

1 Departments of Dermatology and Skin Science, University of British Columbia, Vancouver, Canada.

Background:: Ki-67 is an immunohistochemical stain used as a nuclear proliferation marker. It is nonspecific, and is expressed in all active phases of the cell cycle. Vulvar vestibular papules in women and pearly penile papules in men are benign fibrous papules on the genitals, are noninfectious, and do not require treatment. Read More

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December 2018
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"A child may be tall but also stunted." Conceptualization of and meanings attached to childhood height and short stature in rural Tanzania.

Matern Child Nutr 2018 Dec 16:e12769. Epub 2018 Dec 16.

Population Research Centre, Faculty of Spatial Sciences, University of Groningen, The Netherlands.

Stunting affects large numbers of under-fives in Tanzania. But do caretakers of under-fives recognize height as a marker of child growth? What meanings do they attach to linear growth? An ethnographic study using cultural schemas theory was conducted in a rural community in Southeastern Tanzania to investigate caregivers' conceptualizations of child height in relation to growth and the meanings attached to short stature. Data for the study was collected through 19 focus group discussions, 30 in-depth interviews, and five key informant interviews with caregivers of under-fives, including mothers, fathers, elderly women, and community health workers. Read More

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December 2018
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Preventing secondary exposure to women from men applying a novel nestorone/testosterone contraceptive gel.

Andrology 2018 Dec 16. Epub 2018 Dec 16.

Department of Medicine, Division of Endocrinology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.

Background: Testosterone (T)/Nestorone (NES) combination gel is a potential transdermal male contraceptive that suppresses gonadotropins and spermatogenesis. Transfer of transdermal T from men to women can be prevented by washing or covering application sites with clothing.

Objectives: We hypothesized that showering or wearing a shirt over gel application sites would prevent secondary exposure of T and NES to a woman after close skin contact. Read More

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December 2018
1 Read

Cellular retinol-binding protein-1 expression increases with increasing clinical severity of alopecia areata.

J Cosmet Dermatol 2018 Dec 16. Epub 2018 Dec 16.

Department of Pathology, Faculty of medicine, Tanta University, Tanta, Egypt.

Background: Alopecia areata (AA) is multifactorial disease mostly autoimmune affecting anagen hair follicles. Many researchers hypothesize that adequate retinoic acid (RA) levels are important for proper hair follicle behavior. Previous animal studies revealed increase in RA synthesis proteins and decrease in RA degradation proteins in AA patients when compared with controls. Read More

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December 2018
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A case of ochronosis successfully treated with the picosecond laser.

J Cosmet Dermatol 2018 Dec 16. Epub 2018 Dec 16.

Clínica Dermatológica Isela Méndez, Ciudad de México, México.

Exogenous ochronosis is a cutaneous condition characterized by blue-black pigmentation resulting as a complication of long-term application of skin-lightening creams containing hydroquinone and other substances such as quinine, phenol and mercury derivatives. We report a case of a 55-year-old woman who developed exogenous ochronosis as a result of prolonged use of topical hydroquinone for 5 years, characterized by greyish hyperpigmented patches on the nose and cheeks. The diagnosis was confirmed histologically. Read More

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December 2018
1 Read

Automatic measurement of air gap for proton therapy using orthogonal x-ray imaging with radiopaque wires.

J Appl Clin Med Phys 2018 Dec 16. Epub 2018 Dec 16.

Department of Radiation Oncology, Rutgers-Cancer Institute of New Jersey, Rutgers-Robert Wood Johnson University Hospital, Rutgers-The State University of New Jersey, New Brunswick, NJ, USA.

Purpose: The main objective of this study was to develop a technique to accurately determine the air gap between the end of the proton beam compensator and the body of the patient in proton radiotherapy.

Methods: Orthogonal x-ray image-based automatic coordinate reconstruction was used to determine the air gap between the patient body surface contour and the end of beam nozzle in proton radiotherapy. To be able to clearly identify the patient body surface contour on the orthogonal images, a radiopaque wire was placed on the skin surface of the patient as a surrogate. Read More

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December 2018
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Peroxisome proliferator-activated receptor-α agonist and all-trans retinoic acid induce epithelial differentiation of subcutaneous adipose-derived stem cells from debrided burn skin.

J Cell Biochem 2018 Dec 16. Epub 2018 Dec 16.

Combat Trauma and Burn Injury Research, United States Army Institute of Surgical Research, Fort Sam Houston, Texas.

This study demonstrates that adipose-derived stem cells from debrided skin (dsASCs) of burn patients can be isolated in sufficient quantities and differentiated into cytokeratin-expressing cells by treating them with all-trans retinoic acid (ATRA) and the peroxisome proliferator-activated receptor-α (PPARα) specific activator fenofibrate. Differentiation of dsASCs with ATRA and a combination of growth factors induced expression of simple epithelial markers (KRT7, KRT8, KRT18, and KRT19), along with low levels of stratified epithelial markers (KRT5, KRT10, KRT13, and KRT14). We have optimized a condition to induce dsASCs differentiation to epithelial cells by treatment with ATRA and fenofibrate alone. Read More

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December 2018
1 Read

Improvement in infected wound healing in type 1 diabetic rat by the synergistic effect of photobiomodulation therapy and conditioned medium.

J Cell Biochem 2018 Dec 16. Epub 2018 Dec 16.

Department of Biology and Anatomical Sciences, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.

We investigated the effects of photobiomodulation therapy (PBMT) and conditioned medium (CM) of human bone marrow mesenchymal stem cells (hBM-MSC) individually and/or in combination on the stereological parameters and the expression of basic fibroblast growth factor (bFGF), hypoxia-inducible factor (HIF-1α), and stromal cell-derived factor-1α (SDF-1α) in a wound model infected with methicillin-resistant Staphylococcus aureus (MRSA) in diabetic rats. CM was provided by culturing hBM-MSCs. Type 1 diabetes mellitus (T1DM) was induced in 72 rats, divided into four groups, harboring 18 rats each: group 1 served as a control group, group 2 received PBMT, group 3 received CM, and group 4 received CM + PBMT. Read More

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December 2018
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Pancreatic Enzyme Supplementation in Patients with Atopic Dermatitis and Food Allergies: An Open-Label Pilot Study.

Paediatr Drugs 2018 Dec 17. Epub 2018 Dec 17.

Division of Gastroenterology, Departments of Medicine and Pediatrics, Research Institute of the McGIll University Health Centre, 1650 Cedar Avenue C10.145, Montreal, QC, H3G 1A4, Canada.

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects both patients and their families. Current therapies often alleviate symptoms but do not prevent or eradicate the disease.

Objectives: Our objective was to determine whether pancreatic enzyme supplementation is an effective and safe treatment in refractory pediatric AD associated with food allergies. Read More

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December 2018
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The prevalence and characteristics of local allergic rhinitis in Poland.

Rhinology 2018 Dec 17. Epub 2018 Dec 17.

Clinical Department of Otorhinolaryngology and Laryngological Oncology in Zabrze, Medical University of Silesia, Katowice, Poland.

Background: Local allergic rhinitis (LAR) is found in some patients with typical symptoms but who have negative skin prick tests and negative IgE to aeroallergens while presenting with positive nasal provocation tests for proper allergens. Little information about the clinical characteristics and prevalence of LAR has been published. The aim of this study was to determine the prevalence and characteristics of LAR in patients with symptoms of chronic rhinitis. Read More

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December 2018
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Concordance and Reproducibility of Melanoma Staging According to the 7th vs 8th Edition of the .

JAMA Netw Open 2018 May;1(1)

Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (Elmore); Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia (Elder); Department of Pathology, Institut Curie, Paris, France (Barnhill); Paris Sciences and Lettres Research University, Paris, France (Barnhill); Faculty of Medicine, University of Paris Descartes, Paris, France (Barnhill); Pathology Associates, Clovis, California (Knezevich); Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, Washington (Longton, Pepe); Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire (Titus); Department of Pediatrics, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire (Titus); Norris Cotton Cancer Center, Lebanon, New Hampshire (Titus); Center for Dermatoepidemiology, Providence Veterans Affair Medical Center, Providence, Rhode Island (Weinstock); Department of Dermatology, Brown University, Providence, Rhode Island (Weinstock); Department of Epidemiology, Brown University, Providence, Rhode Island (Weinstock); Department of Medical Informatics and Clinical Epidemiology, School of Medicine, Oregon Health and Science University, Portland (Nelson); Department of Medicine, School of Medicine, Oregon Health and Science University, Portland (Nelson); Department of Medicine, University of Washington School of Medicine, Seattle (Reisch, Radick, Piepkorn); Dermatopathology Northwest, Bellevue, Washington (Piepkorn).

Importance: The recently updated American Joint Committee on Cancer (AJCC) classification of cancer staging, the , 8th edition (), includes revisions to definitions of T1a vs T1b or greater. The Melanoma Pathology Study database affords a comparison,of pathologists' concordance and reproducibility in the microstaging of melanoma according to both the existing 7th edition ) and the new .

Objective: To compare and to examine whether changes to the definitions of T1a and T1b or greater are associated with changes in concordance and reproducibility. Read More

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May 2018
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Pathogenesis of Hypervirulent Group A Streptococcus.

Jpn J Med (Lond) 2018 ;1(6):269-275

Department of Microbiology and Immunology, Montana State University, Bozeman, MT 59718, USA.

Group A (GAS) causes common pharyngitis and skin infections and occasional severe invasive infections. This review describes the recent progress on the pathogenesis of hypervirulent GAS. CovRS mutations are frequent among invasive GAS isolates and lead to hypervirulence. Read More

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January 2018
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Rolling Dynamics of Nanoscale Elastic Shells Driven by Active Particles.

ACS Cent Sci 2018 Nov 1;4(11):1537-1544. Epub 2018 Nov 1.

Department of Polymer Science, University of Akron, Akron, Ohio 44325, United States.

Self-propelled elastic shells capable of transducing energy to rolling motion could have potential applications as drug delivery vehicles. To understand the dynamics of the nanoscale size elastic shells, we performed molecular dynamics simulations of shells filled with a mixture of active and passive beads placed in contact with an elastic substrate. The shell skin is made of cross-linked polymer chains. Read More

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November 2018
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Patient selection criteria and innovative techniques for improving outcome and cosmesis in acne keloidalis nuchae lesion excision and primary closure.

JAAD Case Rep 2019 Jan 4;5(1):24-28. Epub 2018 Dec 4.

Dermatology Division, Harbor-UCLA Department of Medicine, Torrance, California.

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January 2019
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