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Cell Mol Biol Lett 2019 8;24. Epub 2019 Mar 8.

Department of Burn and Plastic Surgery, The First People's Hospital of Nantong, Nantong, 226001 China.

Background: Cutaneous squamous cell carcinoma (CSCC) is a common type of skin malignancy. MicroRNA-221 (miRNA-221) is a critical non-coding RNA in tumor initiation and progression. However, the molecular mechanisms of miRNA-221 in the development of CSCC remain unknown. Read More

Int J Surg Case Rep 2019 7;56:96-100. Epub 2019 Mar 7.

Multidisciplinary Department of Medical and Dental Specialties, Università degli Studi della Campania "Luigi Vanvitelli", Plastic Surgery Unit, Naples, Italy.

Introduction: Metastases represent one of the most outstanding characteristics of malignant neoplasms and are relatively rare in the skin, in spite of the great extension of the cutaneous organs. Development of cutaneous metastases from colon cancer is a rare event, usually occurring in widely disseminated disease and commonly leading to a poor prognosis. As to location, cutaneous metastases often favor areas close to the primary malignancy, such as lung cancer and skin metastases on the trunk. Read More

Arch Craniofac Surg 2019 Feb 1;20(1):58-61. Epub 2019 Feb 1.

Department of Plastic and Reconstructive Surgery, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.

Chronic burn scars often cause various skin malignancies at rates of up to 2%. These lesions are usually squamous cell carcinomas, but rarely, malignant melanoma is reported. We report a 67-year-old male with a malignant melanoma on a burn scar with regional metastasis. Read More

Fam Cancer 2019 Apr;18(2):193-196

Department of Dermatology, Academic Medical Centre, Amsterdam, The Netherlands.

Lynch syndrome (LS) is an autosomal-dominant inherited disorder characterized by a predisposition to colorectal cancer and extracolonic cancers (particularly endometrium, ovary, stomach, small bowel, hepatobiliary tract, pancreas, urothelial tract, brain, and skin). Muir-Torre syndrome (MTS) is considered a phenotypical variant of LS, where patients develop sebaceous neoplasms and keratoacanthomas. Currently, only few studies and case reports suggest an association between LS and other skin cancers, such as Bowens' disease, melanoma and squamous cell carcinoma (SCC). Read More

Curr Med Sci 2018 Dec 7;38(6):1038-1044. Epub 2018 Dec 7.

Department of Plastic Surgery, Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Marjolin's ulcer (MU) is a rare but aggressive epidermoid carcinoma observed in scars or wounds. This article provides comprehensive characteristics and prognostic details of MU. Clinical data of 40 patients with MU between January 2010 and December 2017 were analyzed retrospectively. Read More

J Dermatol Sci 2018 Dec 3;92(3):230-236. Epub 2018 Nov 3.

Prognosis and Statistical Investigation Committee, Japanese Skin Cancer Society, Japan; Department of Dermatology and Plastic Surgery, Kumamoto University, Japan.

Background: There are limited treatment options for advanced non-melanoma skin cancers (NMSCs). To overcome this issue, we need to conduct clinical studies, however, there is a lack of information on how many patients with advanced NMSCs are treated annually in Japan.

Objective: To investigate the actual number of advanced NMSC patients in Japan. Read More

Singapore Med J 2018 Oct;59(10):519-523

Department of Dermatology, Singapore General Hospital, Singapore.

Introduction: Lifelong immunosuppression after renal transplant exerts effects on the recipients' skin, including skin infections, skin cancers and drug-induced skin disorders. Our study aimed to determine the epidemiology of skin conditions among renal transplant recipients in the largest tertiary hospital in Singapore.

Methods: We reviewed the medical records of kidney transplant recipients at Singapore General Hospital, Singapore, between 1 January 2003 and 31 December 2013. Read More

Anticancer Res 2018 Oct;38(10):5825-5830

Department of Radiation Oncology, Cleveland Clinic, Cleveland, OH, U.S.A.

Background/aim: There are limited data regarding survival, failure patterns, and factors associated with disease recurrence in patients with cutaneous squamous cell cancer of the head and neck (cSCC-HN) with nodal metastases.

Patients And Methods: A retrospective analysis of patients with cSCC-HN metastatic to cervical and/or parotid lymph nodes treated with surgery and post-operative radiation therapy was performed.

Results: This study included 76 patients (57 immunocompetent and 18 immunosuppressed) with a median follow-up of 18 months. Read More

Oncol Rep 2018 Dec 28;40(6):3830-3842. Epub 2018 Sep 28.

Department of Plastic and Reconstructive Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.

Cutaneous squamous cell carcinoma (cSCC) is one of the most common skin cancers. However, the efficacy and utility of the available drug therapies are limited. The objective of the present study was to determine the genes and molecular pathways associated with cSCC by using computational tools and publicly available data, and to explore drugs targeting the relevant molecular pathways for cSCC treatment. Read More

Plast Reconstr Surg 2018 09;142(3):373e-387e

Dallas, Texas From the Department of Plastic Surgery, University of Texas Southwestern Medical Center.

Learning Objectives: After studying this article, the participant should be able to: 1. Characterize basal and squamous cell carcinomas as low or high risk based on size, location, histology, and clinical features. 2. Read More

Int J Mol Sci 2018 Aug 23;19(9). Epub 2018 Aug 23.

Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Frankfurt Orofacial Regenerative Medicine (FORM), Medical Center Goethe-University Frankfurt am Main, 60590 Frankfurt am Main, Germany.

Vismodegib, an inhibitor of the Hedgehog signaling pathway, is an approved drug for monotherapy in locally advanced or metastatic basal cell carcinoma (BCC). Data on combined modality treatment by vismodegib and radiation therapy, however, are rare. In the present study, we examined the radiation sensitizing effects of vismodegib by analyzing viability, cell cycle distribution, cell death, DNA damage repair and clonogenic survival in three-dimensional cultures of a BCC and a head and neck squamous cell carcinoma (HNSCC) cell line. Read More

Plast Reconstr Surg 2018 11;142(5):818e-819e

Royal Prince Alfred Hospital Westmead Clinical School, Westmead and, Institute of Academic Surgery, Royal Prince Alfred Hospital, University of Sydney Institute of Academic Surgery, Royal Prince Alfred Hospital, University of Sydney and Department of Head and Neck Surgery, Chris O'Brien Lifehouse Cancer Centre Institute of Academic Surgery, Royal Prince Alfred Hospital, University of Sydney, Department of Head and Neck Surgery, Chris O'Brien Lifehouse Cancer Centre, and Department of Plastic Surgery, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.

Int J Surg Case Rep 2018 8;50:122-125. Epub 2018 Aug 8.

Department of Plastic & Reconstructive Surgery, Rambam Health Care Campus, Haifa, Israel.

Introduction: Cutaneous squamous cell carcinoma (SCC) is a common skin cancer, second in incidence only to basal cell carcinoma (BCC). The incidence of SCC increases significantly with age; thus, it is rarely diagnosed in young patients. In this paper, we present two cases of young patients who presented clinically with purulent lesions that were later diagnosed as large primary SCCs. Read More

Int J Dermatol 2018 Oct 13;57(10):1208-1217. Epub 2018 Aug 13.

Department of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.

Background: Actinic keratosis (AK) is an incipient form of cutaneous squamous cell carcinoma (cSCC). Understanding the differentially expressed genes between AK and cSCC states would be helpful for the early prevention and treatment of cSCC. Consequently, this study aimed to screen the key genes associated with the progression of AK to cSCC. Read More

Biochem Biophys Res Commun 2018 09 30;503(3):1941-1948. Epub 2018 Jul 30.

Department of Plastic Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, China. Electronic address:

GDC-0084 is a novel and potent small-molecule PI3K-mTOR dual inhibitor. The present study examined its potential activity in cutaneous squamous cell carcinoma (cSCC) cells. Our results show that GDC-0084 treatment at nanomole concentrations potently inhibited survival and proliferation of established (A431, SCC-13 and SCL-1 lines) and primary human cSCC cells. Read More

Dermatology 2018 31;234(3-4):99-104. Epub 2018 Jul 31.

Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.

Background: Skin cancer removal surgery involving the tip or dorsum of the nose often results in large-sized defects with exposure of cartilage. In such cases, the paramedian forehead flap is a frequently used reconstruction technique; however, this method is complex and can result in a cosmetically unsatisfying outcome.

Objective: To describe the folded transposition flap as an aesthetically pleasing alternative to the paramedian forehead flap for large nasal defects with exposed cartilage. Read More

Wounds 2018 Jul;30(7):E68-E70

Department of Orthopaedics and Rehabilitation, Yale School of Medicine; and Yale Podiatric Foot and Ankle Surgery Residency Program, New Haven, CT.

Introduction: Squamous cell carcinoma (SCC) is most commonly found on sun-damaged skin and less often occurs on the toes and feet.

Case Report: A 41-year-old man with a history of human immunodeficiency virus and asthma, who had received highly active antiretroviral therapy for 7 years while incarcerated, presented to the emergency department with a primary SCC of the left foot with inguinal lymph node metastasis. The patient underwent a left foot transmetatarsal amputation; due to noncompliance, he underwent a below-the-knee amputation 17 days later as a result of surgical findings and extent of infection. Read More

Ulus Travma Acil Cerrahi Derg 2018 Jul;24(4):364-368

Department of Plastic, Reconstructive and Aesthetic Surgery, Acıbadem Mehmet Ali Aydınlar University, Acıbadem Maslak Hospital, İstanbul-Turkey.

Background: Extensive scalp defects caused by various etiologies often require free-tissue transfer. We aimed to review our experience in the reconstruction of extensive scalp defects with free anterolateral flaps.

Methods: A retrospective analysis was performed on all patients with extensive scalp defects that were reconstructed with free anterolateral thigh flaps from November 2007 to April 2015. Read More

Rom J Morphol Embryol 2018 ;59(1):345-352

Department of Plastic Surgery and Reconstructive Microsurgery, Emergency Clinical Hospital of Bucharest, Romania;

The risk of developing basal cell carcinoma (BCC) during lifetime varies between 29-55%, while for squamous cell carcinoma (SCC) varies between 7-11%. Between them, considered to be a BCC, there is a particular histological type, named metatypical basal cell carcinoma (MTC) or basosquamous cell carcinoma (BSCC). In this paper, we presented a rare case of metatypical carcinoma of the forehead with an interesting history of unexpected recurrences, underlining the clinical, therapeutic and histological essential aspects that may come in use to other clinicians in managing this type of cancer. Read More

J Am Acad Dermatol 2019 Feb 18;80(2):460-465.e9. Epub 2018 Jun 18.

Department of Neurology, Odense University Hospital, Odense, Denmark; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.

Background: Hydrochlorothiazide use has been associated with markedly increased risk for squamous cell carcinoma. No previous studies have investigated the association between hydrochlorothiazide use and the risk for Merkel cell carcinoma (MCC) and malignant adnexal skin tumors (MAST).

Objective: To examine the association between hydrochlorothiazide use and the risk for MCC and MAST. Read More

G Ital Dermatol Venereol 2018 Dec 11;153(6):747-762. Epub 2018 Jun 11.

Department of Dermatology, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.

Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer, accounting for 20% of all cutaneous malignancies, and has an increasing incidence in the elderly as well as in the younger population. Although most cSCC is treated with simple therapeutic procedures, advanced cSCC can lead a significant risk for morbidity, negative impact on quality of life, and death. Proper management includes distinguishing between high-risk and low-risk lesions and determining treatment accordingly. Read More

Biomed Res Int 2018 2;2018:9489163. Epub 2018 Apr 2.

Dermatology Unit "Daniele Innocenzi", Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Polo Pontino, Rome, Italy.

Cutaneous squamous cell carcinoma (cSCC) is an increasing public health problem. It is a primary malignant skin tumor with Malpighian differentiation and together with basal cell carcinoma is classified among nonmelanoma skin cancers (NMSCs). cSCC usually occurs on photoexposed areas, such as the head, the neck, and the extremities, and its incidence increases with age. Read More

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2018 02;32(2):210-214

Department of Burn and Plastic Surgery, Affiliated Hospital of Zunyi Medical College, Zunyi Guizhou, 563003, P.R.China.

Objective: To explore the effectiveness of propeller facial artery perforator flap to repair the defect after resection of skin malignant tumor at upper lip.

Methods: Between July 2012 and January 2017, 17 cases with skin malignant tumor at upper lip underwent tumor resection and the remained defect was repaired with propeller facial artery perforator flap. Among the 17 patients, 3 were male and 14 were female, with an average age of 57 years (range, 35-82 years). Read More

BMJ Case Rep 2018 May 18;2018. Epub 2018 May 18.

Histopathology Department, Mid Essex Hospital Services NHS Trust, Chelmsford, UK.

Primary cutaneous extraskeletal osteosarcoma (PCEO) is a rare malignant neoplasm with less than 20 cases reported in the literature to date. Presenting as a nodule or mass on the skin, commonly at sites of previous trauma or radiation, these lesions are differentiated from other neoplasms through their characteristic microscopic appearance. This report highlights a case of PCEO in a 75-year-old man with a history of squamous cell carcinoma (SCC) of the scalp. Read More

Cancer Sci 2018 Jul 25;109(7):2178-2187. Epub 2018 Jun 25.

Division of Cancer Chemotherapy, Miyagi Cancer Center Research Institute, Miyagi, Japan.

Here, we address the function of protein phosphatase 6 (PP6) loss on K-ras-initiated tumorigenesis in keratinocytes. To do so, we developed tamoxifen-inducible double mutant (K-ras -expressing and Ppp6c-deficient) mice in which K-ras expression is driven by the cytokeratin 14 (K14) promoter. Doubly-mutant mice showed early onset tumor formation in lips, nipples, external genitalia, anus and palms, and had to be killed by 3 weeks after induction by tamoxifen, while comparably-treated K-ras -expressing mice did not. Read More

J Drugs Dermatol 2018 May;17(5):499-505

Background: An increase in nonmelanoma skin cancer (NMSC) in younger patients has been reported. Many are treated with Mohs micrographic surgery (MMS).

Objective: Investigate patient and tumor characteristics in patients less than 50 years undergoing MMS for NMSC at a large, referral-based practice. Read More

BMJ Case Rep 2018 Apr 28;2018. Epub 2018 Apr 28.

Department of Plastic and Reconstructive Surgery, Odense University Hospital, Odense, Denmark.

A 60-year-old male patient with a large infected cranial apex lesion was admitted with lethargy and mental status changes. The patient underwent evaluation with imaging studies, a skin biopsy, cultures with microscopy and a diagnostic burr hole. MRI and positron emission tomography/CT scan revealed a squamous cell carcinoma with ingrowth in the midline of the brain and subdural empyema infected with and High dose intravenous antibiotic treatment was initiated and the patient subsequently underwent a surgical resection of the carcinoma with a 1 cm margin of surrounding skin and skull. Read More

Eur J Cancer 2018 06 14;96:34-43. Epub 2018 Apr 14.

Department of Dermatology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.

Background: Advanced cutaneous squamous cell carcinoma (aSCC) is an area of unmet medical need and no treatment standards are established. Recently, an anti-PD-1 inhibitor received FDA breakthrough therapy designation. The aim of the study was to describe the clinical course, therapeutic management and prognosis of aSCC under real-life conditions. Read More

Ann Chir Plast Esthet 2018 Jul 9;63(4):343-348. Epub 2018 Apr 9.

Department of plastic reconstructive and aesthetic surgery, university hospital of Picardie, 80054 Picardie cedex 1, France. Electronic address:

Objective: Perineal defects are encountered ever more frequently, in the treatment of vulvar cancers or abdominoperineal resection. The surgical treatment of vulvar cancer leads to significant skin defect. The aim of the reconstruction is not to provide volume but rather to resurface perineum. Read More

J Burn Care Res 2018 Jun;39(4):636-639

Department of Medicine, Surgery and Neuroscience, Unit of Plastic Surgery, University of Study of Siena, Siena, Italy.

Marjolin's ulcer is an aggressive disease arising in chronic wounds and cutaneous scars. Corbo et al define Marjolin's ulcer an often overlooked or misdiagnosed tumor. We report a case of Marjolin's ulcer arose in a burn scar of a 51-year-old man who sustained a burn in childhood. Read More

J Craniofac Surg 2018 Sep;29(6):1574-1577

Department of Plastic Surgery, Ankara Oncology Training and Research Hospital, Ankara, Turkey.

Introduction: Reconstruction of facial defects is not only important for cosmesis but also for the function. Local flaps are considered the best reconstruction method for facial defects. The authors want to show the feasibility of free style facial perforator flap for the reconstruction of moderate sized mid-facial defects. Read More

G Ital Dermatol Venereol 2018 Apr;153(2):278-282

Division of Plastic Surgery, Department of Surgical Sciences, University of Parma, Parma, Italy.

The skin cancers of the head and neck district are localized mostly on the nose, which, by being in the center of the mid-face, has an important aesthetic role. Therefore, many reconstructive techniques have been studied; among them regional skin flaps appeared the most suitable since they guaranteed the oncological radicality as well as a good aesthetic outcome. In this paper, we present our experience with the use of the Zitelli bilobed flap, which is defined as a double transposition flap for the reconstruction of the nose defects. Read More

Exp Clin Transplant 2018 Mar;16 Suppl 1(Suppl 1):95-100

From the Department of Plastic and Reconstructive Surgery, Baskent University Faculty of Medicine, Ankara, Turkey.

Objectives: Skin cancers are one of the most common malignancies in solid-organ transplant recipients. Increased age and immunosuppressive drug use are risk factors for posttransplant skin malignancies. We evaluated nonmelanocytic skin cancer incidence and development time in transplant patients. Read More

Plast Reconstr Surg 2018 03;141(3):469e-471e

Department of Plastic Surgery, MedStar Georgetown University Hospital, Washington, D.C.

J Craniofac Surg 2018 May;29(3):735-737

Department of Plastic Reconstructive and Aesthetic Surgery.

Free flaps based on static slings principles cannot provide esthetic and functional outcomes at a desired level in total or close to total lip loss. Therefore, dynamic methods have become a current issue in recent years and especially the idea of functional gracilis free muscle flap has been suggested. In this study, we present a case of a successful total lower lip repair with this flap. Read More

J Craniofac Surg 2018 May;29(3):608-613

Department of Orthopaedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

Reconstruction of scalp defects caused by tumor resection or trauma is very challenging. A majority of the surgeons prefer to use local flap rather than skin graft or free flap for scalp defects repair. The aim of this study is to investigate the technique of modified unilateral pedicled V-Y advancement flap for the reconstruction of scalp defect. Read More

Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.

Division of Dermatology, University of Kansas Medical Center, Kansas City, Kansas.

Background: Hydroxyurea is an antimetabolite primarily used to treat myeloproliferative disorders, and chronic treatment is associated with many cutaneous adverse effects ranging in severity from ichthyosis to aggressive nonmelanoma skin cancer.

Case Presentation: We report a 67-year-oldman with a history of polycythemia vera who was referred for management of progressively worsening dorsal hand lesions. The patient presented withhyperpigmentation, ichthyosis, plantar keratoderma, dermatomyositis-like eruptions, two squamous cell carcinomas, and actinic keratoses. Read More

Saudi Med J 2018 Feb;39(2):213-216

Department of Plastic Reconstructive and Aesthetic Surgery, Faculty of Medicine, Celal Bayar University, Manisa, Turkey. E-mail.

Objectives: To emphasize different clinical features of tumor that can be misdiagnosed clinically.

Methods: A total of 8 cases operated between September 2009 and 2016 at the Celal Bayar University, Faculty of Medicine were included in the study. Patients' clinicopathological features, type of surgery and follow up information were evaluated. Read More

J Am Acad Dermatol 2018 03 10;78(3):560-578. Epub 2018 Jan 10.

Department of Family Medicine, University of Michigan, Ann Arbor, Michigan.

Cutaneous squamous cell carcinoma (cSCC) is the second most common form of human cancer and has an increasing annual incidence. Although most cSCC is cured with office-based therapy, advanced cSCC poses a significant risk for morbidity, impact on quality of life, and death. This document provides evidence-based recommendations for the management of patients with cSCC. Read More

BMJ Case Rep 2018 Jan 11;2018. Epub 2018 Jan 11.

Department of Plastic Surgery, South Eastern Health and Social Care Trust, Dundonald, UK.

J Craniofac Surg 2018 May;29(3):668-670

Department of Plastic and Reconstructive Surgery, Toho University Omori Medical Center, Tokyo, Japan.

Background: Lower lip reconstruction requires consideration of esthetic and functional outcome in selecting a surgical procedure, and reconstruction with local tissue is useful. The authors reconstructed full-thickness defects with a unit advancement flap.

Methods: Reconstruction was performed using this method in 4 patients with lower lip squamous cell carcinoma in whom tumor resection with preservation of the mouth angle was possible. Read More

J Am Acad Dermatol 2018 04 4;78(4):673-681.e9. Epub 2017 Dec 4.

Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark. Electronic address:

Background: Hydrochlorothiazide, one of the most frequently used diuretic and antihypertensive drugs in the United States and Western Europe, is photosensitizing and has previously been linked to lip cancer.

Objective: To examine the association between hydrochlorothiazide use and the risk of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC).

Methods: From the Danish Cancer Registry, we identified patients (cases) with nonmelanoma skin cancer (NMSC) during 2004-2012. Read More

J Eur Acad Dermatol Venereol 2018 Jul 22;32(7):1147-1154. Epub 2017 Dec 22.

Dermatologic Clinic, 'Sapienza' University of Rome, Rome, Italy.

Background: Electrochemotherapy (ECT) is currently used to treat unresectable superficial tumours of different histotypes through the combination of cytotoxic chemotherapy and local application of electric pulses. In 2006, a collaborative project defined the ESOPE (European Standard Operating Procedures of Electrochemotherapy) guidelines to standardize the procedure. The International Network for Sharing Practices of Electrochemotherapy (InspECT) aims to refine the ESOPE and improve clinical practice. Read More

J Plast Reconstr Aesthet Surg 2018 04 23;71(4):597-603. Epub 2017 Nov 23.

Plastic and Reconstructive Surgery Department, Hospital of Lithuanian University of Health Sciences Kauno Klinikos, Eivenių str. 2, Kaunas, Lithuania; Medical faculty, Lithuanian University of Health Sciences, A. Mickevičiaus str. 9, Kaunas, Lithuania.

Background: Cutaneous squamous cell carcinoma (CSCC) is the second most common malignant skin cancer with a tendency to spread through the lymphogenic pathway. Metastases are found in 2-6% of cases. The aim of this study was to determine CSCC micrometastases when non-invasive examination methods do not detect them. Read More

J Dermatol 2018 Feb 15;45(2):220-223. Epub 2017 Nov 15.

Department of Dermatology, Kansai Medical University Medical Center, Osaka, Japan.

Case 1 was a 75-year-old Japanese man who presented with a poorly demarcated, dark-red nodule with a destructive defect in the center, measuring 3 cm × 2 cm on the right wing of his nose. The histological diagnosis was a common form of infundibular squamous cell carcinoma. Atypical neoplastic cells radiated from the wall of a follicular infundibulum. Read More

Aesthetic Plast Surg 2018 Feb 9;42(1):310-321. Epub 2017 Nov 9.

Department of Plastic, Aesthetic, Reconstructive and Hand Surgery, AGAPLESION Diakonieklinikum Rotenburg, Elise-Averdieck-Straße 17, 27356, Rotenburg (Wümme), Germany.

Background: The literature reports many cases of cutaneous malignancy in the setting of skin tattoos. In this study, we review the reported incidence of and risk factors for tattoo-associated skin cancer.

Methods: A PubMed literature review was performed for all cases of tattoo-associated skin cancer, including squamous cell carcinoma, basal cell carcinoma, malignant melanoma, keratoacanthoma, and other rare skin malignancies (source: PubMed/until June 2017). Read More

J Plast Reconstr Aesthet Surg 2018 02 20;71(2):262-264. Epub 2017 Oct 20.

Department of Plastic and Maxillofacial Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Oral Oncol 2017 11 9;74:123-129. Epub 2017 Oct 9.

Department of Oral and Maxillofacial Surgery, Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China. Electronic address:

Objective: To explore a new method of reconstruction of through-and-through cheek defects and to evaluate this method's efficacy and patient prognosis.

Materials And Methods: This retrospective study included 70 patients who underwent reconstruction of through-and-through cheek defects. The surgical approach, design of facial skin incisions, selection and design of flaps, postoperative quality of life and prognosis of patients were recorded and reported. Read More

Arch Craniofac Surg 2017 Sep 26;18(3):191-196. Epub 2017 Sep 26.

Department of Plastic and Reconstructive Surgery, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Basal cell carcinoma (BCC) comprising several lesions is not uncommon, but nonsyndromic multiple BCCs with parotid invasion are rare entities. We present two cases of multiple sporadic, nonsyndromic BCCs, and one of these cases is a unique case of parotid invasion associated purely with actinic keratosis. In Case 1, a 79-year-old female presented with multiple skin lesions on the face and left hand. Read More

J Surg Oncol 2018 Mar 26;117(3):473-478. Epub 2017 Oct 26.

Department of Plastic Surgery, Medisch Centrum Leeuwarden, Leeuwarden, The Netherlands.

Background And Objectives: We excised cutaneous squamous cell carcinoma (cSCC) of the face while using intra-operative frozen section analysis of the margins in an optimized bread-loafing fashion (WIFSA).

Methods: Medical records were reviewed of 160 cSCCs of the face that were treated by surgical excision with WIFSA between April 2007 and January 2013. The accuracy of WIFSA was verified by comparing results with postoperative formalin-fixed paraffin-embedded (FFPE) sections. Read More