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Sci Rep 2021 Jun 11;11(1):12391. Epub 2021 Jun 11.

Department of Plastic, Reconstructive and Aesthetic Surgery, Second Chair of Surgery Medical, University of Lodz, Lodz, Poland.

Skin cancers are the most common neoplasms; frequently, they localize on the face. The aim of paper is to present the incidence of skin tumors in a single center from 2017 to 2019, describe trends in its frequency and find relations between neoplasms and sex, type of cancer, and its size. An analysis of histopathological files from the surgical department between 2017 and 2019 was calculated. Read More

Acta Otorhinolaryngol Ital 2021 Apr;41(Suppl. 1):S145-S157

Plastic and Reconstructive Surgery Unit, "A. Gemelli" Hospital Foundation IRCCS, Catholic University of the Sacred Heart, Rome, Italy.

J Plast Surg Hand Surg 2021 May 25:1-5. Epub 2021 May 25.

Division of Plastic Surgery, Mayo Clinic, Rochester, MN, USA.

The aim of this study is to report our institution's experience with pediatric skin malignancies. A single institution retrospective review of pediatric patients with a primary skin malignancy from 1992 to 2020 was performed. Demographics, tumor characteristics and treatment outcomes were reviewed. Read More

Facial Plast Surg 2021 Jun 14;37(3):407-410. Epub 2021 Apr 14.

Plastic Reconstructive and Aesthetic Surgery Department, Cumhuriyet University Medical Faculty, Sivas, Turkey.

The nose is highly vulnerable to skin cancers due to the unavoidable sun exposure. The most common localization of skin cancers on the face is nose. Although the nose appears to be a single structure, it comprises many aesthetic units with different histological and anatomical properties. Read More

ANZ J Surg 2021 05 15;91(5):871-877. Epub 2021 Mar 15.

Midlands Regional Plastic and Reconstructive Surgery Unit, Waikato District Health Board, Hamilton, New Zealand.

Background: 'Skin Shop' is a model of care at a high-volume tertiary centre that describes a registrar-lead skin cancer service under consultant supervision. Ninety-two percent of lesions are completely excised, 4.2% are narrowly excised and 3. Read More

Arch Craniofac Surg 2020 Dec 20;21(6):363-367. Epub 2020 Dec 20.

Department of Plastic and Reconstructive Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

Cutaneous squamous cell carcinoma (cSCC) is the second most common nonmelanoma skin cancer, and its incidence is increasing globally. In Korea, there were 12,516 diagnosed cases of cSCC between 1999 and 2014. Surgical treatment, for which several options are available, is the standard of care for cSCC and securing a sufficient surgical resection margin is always important. Read More

BMC Surg 2021 Feb 23;21(1):100. Epub 2021 Feb 23.

Department of Plastic and Hand Surgery, Medical Center - University of Freiburg, Faculty of Medicine, Comprehensive Cancer Center Freiburg, University of Freiburg, Freiburg, Germany.

Background: Epidermolysis bullosa is a group of rare inherited skin diseases characterized by blister formation following mechanical skin trauma. Epidermolysis bullosa is associated with increased skin cancer rates, predominantly squamous cell carcinomas, yet to our best knowledge, there is no reported case of dermatofibrosarcoma protuberans in a patient with Epidermolysis bullosa.

Case Presentation: Here, we present a 26-year-old man with junctional epidermolysis bullosa, who developed a DFSP on the neck. Read More

Facial Plast Surg 2021 Jun 27;37(3):390-394. Epub 2021 Jan 27.

Department of Otolaryngology, Columbia University, New York, New York.

This article determines if patient, defect, and repair factors can be used to predict the use of additional treatments to achieve optimal aesthetic results after repair of facial Mohs defects. An electronic chart review of patients undergoing Mohs excision and reconstruction of facial neoplasms from November 2005 to April 2017 was performed, reviewing patient demographics and history, tumor size, defect size and location, method and service of reconstruction, time between resection and repair, complications, and subsequent treatments. A total of 1,500 cases with basal cell and squamous cell carcinoma were analyzed. Read More

BMC Surg 2021 Jan 18;21(1):41. Epub 2021 Jan 18.

School of Medicine, National Yang-Ming University, Taipei, Taiwan.

Background: Scalp reconstruction is a common challenge for surgeons, and there are many different treatment choices. The "crane principle" is a technique that temporarily transfers a scalp flap to the defect to deposit subcutaneous tissue. The flap is then returned to its original location, leaving behind a layer of soft tissue that is used to nourish a skin graft. Read More

Anticancer Res 2021 Jan;41(1):289-295

Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, U.S.A.

Background/aim: Satellitosis/in-transit metastasis (S-ITM) has prognostic value in melanoma and Merkel cell carcinoma, but is not incorporated into cutaneous squamous cell carcinoma (cSCC) staging.

Patients And Methods: From our IRB-approved registry, patients with high-risk cSCC, including patients with S-ITM, were identified. Univariate (UVA) and multivariate (MVA) analyses were performed to compare disease progression (DP) and overall survival (OS). Read More

Medicine (Baltimore) 2020 Dec;99(51):e23789

Department of Plastic and Reconstructive Surgery.

Abstract: Skin cancer diagnoses are rising due to increasing ultraviolet ray exposure and an aging population. The complete surgical excision of skin cancer, including a normal tissue, has been the widely performed and determining the adequate safety margin is essential. In this study, we compared the preoperative thickness and width of skin cancer by ultrasonography with the measurements by histopathologic findings. Read More

BMJ Case Rep 2020 Dec 9;13(12). Epub 2020 Dec 9.

Department of Surgery, Division of Plastic and Reconstructive Surgery, University of California San Francisco, San Francisco, California, USA.

For patients whose vasculitis is managed with biologic medications, no reports or evidence-based guidance exists regarding the perioperative management of microvascular flaps. We present a case of a 78-year-old patient with Takayasu's arteritis (TA) and diabetes mellitus who was taking infliximab and underwent wide local excision of squamous cell carcinoma, craniectomy and reconstruction with a latissimus dorsi flap. TA, an immune-mediated large cell vasculitis characterised by granuloma formation, tends to affect larger vessels and aortic branches. Read More

J Plast Reconstr Aesthet Surg 2021 03 1;74(3):644-710. Epub 2020 Nov 1.

Department of Plastic and Reconstructive Surgery, Royal Free NHS Foundation Trust London, United Kingdom.

J Plast Reconstr Aesthet Surg 2021 03 2;74(3):644-710. Epub 2020 Nov 2.

Department of Plastic and Reconstructive Surgery, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Castle Road, Cottingham HU16 5JQ, England.

J Plast Reconstr Aesthet Surg 2021 04 7;74(4):890-930. Epub 2020 Nov 7.

Department of Plastic Surgery, Cambridge University Hospitals NHS Trust, Cambridge CB2 0QQ, United Kingdom; Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, United Kingdom. Electronic address:

World J Mens Health 2020 Aug 28. Epub 2020 Aug 28.

Department of Urology, Tianjin Medical University General Hospital, Tianjin, China.

Purpose: We conducted a systematic review and meta-analysis to quantify the association between phosphodiesterase type 5 inhibitors (PDE5Is) use and skin cancers and we also examined whether down-expression of the PDE5A gene was related to worse prognosis for malignant melanoma (MM) patients.

Materials And Methods: The PubMed, Cochrane Library, Web of Science, EMBASE, and ClinicalTrails.gov databases were searched. Read More

Br J Dermatol 2021 03 18;184(3):401-414. Epub 2021 Jan 18.

British Association of Dermatologists, Willan House, 4 Fitzroy Square, London, W1T 5HQ, UK.

Cell Mol Biol (Noisy-le-grand) 2020 Jul 31;66(5):142-147. Epub 2020 Jul 31.

Pharmaceutical Sciences and Cosmetic Products Research Center, Kerman University of Medical Sciences, Kerman, Iran.

The current experiment was performed to explore the effect and possible mechanism of resveratrol on the proliferation, migration and invasion of skin squamous cell carcinoma cells (HSC-5). Tetramethyl azozo blue (MTT) method, Transwell experiment and real-time fluorescence quantitative PCR (RT-qPCR) were used to detect the effects of resveratrol intervention on the proliferation, migration and invasion of HSC-5 cells and the expression of miR-126. The miR-126 mimics and inhibitors were transfected into HSC-5 cells, and the effects of up-regulation or down-regulation of HSC-5 expression on the proliferation, migration and invasion of HSC-5 cells were detected. Read More

J Plast Reconstr Aesthet Surg 2021 02 19;74(2):407-447. Epub 2020 Sep 19.

Department of Plastic Surgery, University Hospital Coventry and Warwickshire, United Kingdom.

Laryngoscope 2021 04 2;131(4):E1198-E1208. Epub 2020 Oct 2.

Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.

Objectives: Squamous cell carcinoma of nasal vestibule and pyramid is rare, thus classification, treatment protocol, and indications for elective neck treatment are still controversial. Nasal reconstruction is challenging, as well, and prosthesis is still used.

Study Design: Retrospective cohort study. Read More

Mol Med Rep 2020 Nov 14;22(5):4236-4242. Epub 2020 Sep 14.

Department of Radiation Oncology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.

DEAD‑Box Helicase 46 (DDX46) is an ATP‑dependent RNA helicase that plays a central role in transcription splicing and ribosome assembly. However, the role of DDX46 in cutaneous squamous cell carcinoma (CSCC) remains to be elucidated. The aim of the present study was to investigate the role of DDX46 in CSCC by assessing DDX46 expression levels in CSCC tissues and cell lines. Read More

J Dermatol 2021 Jan 24;48(1):96-100. Epub 2020 Sep 24.

Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.

A case of xeroderma pigmentosum (XP) group D in a 39-year-old Japanese man is reported. The patient had suffered from moderate to severe solar sensitivity and freckle-like pigmented macules in sun-exposed areas since 6 years of age, and developed skin malignancies such as squamous cell carcinoma, actinic keratosis, Bowen's disease and basal cell carcinoma. The minimal erythema dose for ultraviolet (UV) radiation was decreased with a delayed peak reaction. Read More

Minerva Med 2020 Dec 21;111(6):589-600. Epub 2020 Sep 21.

Dermatology Unit, Luigi Vanvitelli University of Campania, Naples, Italy -

Despite the overall excellent survival rates in patients affected by early cutaneous squamous cell carcinoma (CSCC), advanced forms of CSCC are associated with high patient mortality. To date, only limited therapeutic modalities have been implemented, including chemotherapy and radiotherapy. Systemic therapy was enriched by the addition of epidermal growth factor receptor inhibitors (EGFRi) in the last years. Read More

Acta Chir Plast 2020 ;62(1-2):4-9

Introduction: Diagnosis of malignant cutaneous tumours of the hand is often difficult because of the different anatomic structures present in this region and yet clinicians must be able to distinguish typical benign entities from life-threatening or limb-threatening malignant diseases. Due to the hand's complex structures located in a small area, surgeons must evaluate constantly the balance of inadequate surgery against functional and cosmetic aspects. Thus, a multidisciplinary approach is recommended for a correct diagnosis and treatment design. Read More

Eur J Cancer 2020 10 21;138:30-40. Epub 2020 Aug 21.

Department of Oncology, Herlev and Gentofte Hospital, University of Copenhagen, Herlev, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; Department of Clinical Oncology and Palliative Care, Zealand University Hospital, Roskilde, Denmark. Electronic address:

Background: Electrochemotherapy (ECT) is a treatment for both primary and secondary cutaneous tumours. The international Network for sharing practices on ECT group investigates treatment outcomes after ECT using a common database with defined parameters.

Methods: Twenty-eight centres across Europe prospectively uploaded data over an 11-year period. Read More

Dermatol Online J 2020 Jun 15;26(6). Epub 2020 Jun 15.

Department of Plastic Surgery, Royal Free Hospital, Hampstead, London.

Background: Squamous cell carcinoma (SCC) is the most common malignancy of the upper limb, and can pose a significant therapeutic challenge. Early treatment needs to be radical whilst maintaining function.

Methods: We describe two cases of upper limb squamous cell carcinoma treated with radiotherapy, review the literature on radiotherapy as a primary treatment modality, and discuss the specific difficulties treating SCC in the hand. Read More

J Dermatol 2020 Nov 13;47(11):1317-1321. Epub 2020 Aug 13.

Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.

Merkel cell carcinoma (MCC) is an aggressive neoplasm and patients with metastasis have poor survival outcomes. Recently, avelumab, an anti-programmed death ligand 1 (PD-L1) immune checkpoint inhibitor, was approved for first-line treatment in patients with metastatic MCC. While the administration interval of avelumab is every 2 weeks, the durable effect of a single administration of avelumab is unknown. Read More

Int J Mol Sci 2020 Jul 29;21(15). Epub 2020 Jul 29.

Section of Medical Oncology, Department of Biomedical Sciences and Clinical Oncology (DIMO), University of Bari 'Aldo Moro', 70121 Bari, Italy.

Non-melanoma skin cancers (NMSCs) include basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and Merkel cell carcinoma (MCC). These neoplasms are highly diverse in their clinical presentation, as well as in their biological evolution. While the deregulation of the Hedgehog pathway is commonly observed in BCC, SCC and MCC are characterized by a strikingly elevated mutational and neoantigen burden. Read More

Dermatol Ther 2020 11 14;33(6):e14094. Epub 2020 Aug 14.

Department of Dermatology, Faculty of Medicine, Manisa Celal Bayar University, Manisa, Turkey.

Skin cancers are the most common type of cancer. Nonmelanoma skin cancers (NMSCs) are more common than melanoma. Although the mortality rate is low, cancer word can be frightening for patients. Read More

Arch Craniofac Surg 2020 Jun 29;21(3):188-192. Epub 2020 Jun 29.

Department of Plastic and Reconstructive Surgery, Konkuk University Chungju Hospital, Konkuk University School of Medicine, Chungju, Korea.

The most common forms of nonmelanocytic skin cancer (NMSC) are basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The growing incidence of skin cancer in the Republic of Korea has sparked increasing scientific interest in these types of tumors. In the case described herein, multiple NMSCs occurred asynchronously in various areas of the body in a single patient. Read More