1,318 results match your criteria Skin Malignancies Squamous Cell Carcinoma* Plastic Surgery


Revisiting the value of the 'bandoneon' flap for lower lip reconstruction: a report of two cases and outcome.

J Surg Case Rep 2020 May 23;2020(5):rjaa082. Epub 2020 May 23.

Division of Plastic Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA.

Mild- to moderate-sized lip defects that affect one- to two-thirds of the total lip length often require that utilization of local soft tissue rearrangement in order to re-establish lip anatomy, function and esthetics. The use of local flaps in lip reconstruction often follows oncologic resection of common skin malignancies including basal cell carcinoma and squamous cell carcinoma. When considering the types of flaps to use for lip defects of one- to two-third total length, a variety of flaps designs have been described, each with its benefits in drawbacks. Read More

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http://dx.doi.org/10.1093/jscr/rjaa082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246337PMC

Eyelid Complications Associated with Surgery for Periocular Cutaneous Malignancies.

Facial Plast Surg 2020 Apr 15;36(2):166-175. Epub 2020 May 15.

Department of Ophthalmology, Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan.

Periocular skin is highly prone to malignancies, especially basal cell and squamous cell carcinomas. Because of the complex anatomy and eye-protecting functions of the periocular tissues, treatment of these cancers requires special considerations. Mohs micrographic surgery is usually the treatment of choice, whenever possible, in order to enhance margin control while limiting collateral damage to nearby normal structures. Read More

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http://dx.doi.org/10.1055/s-0040-1709515DOI Listing
April 2020
0.992 Impact Factor

The use of modified keystone flap in periarticular or large superficial tumor resection surgery.

J Surg Oncol 2020 Jun 3;121(7):1090-1096. Epub 2020 Mar 3.

Department of Plastic and Reconstruction, Shanghai Changhai Hospital Affiliated to Second Military Medical University, Shanghai, China.

Background And Objectives: The keystone design perforator island flap (KDPIF) is often used to cover defects in reliable blood supply and similar skin patterns, but its mobility is limited, especially when the wound is large or occurs around joints. Here, we describe a modified KDPIF, boat-shaped flap. We added a V shape along the lateral arc, forming a V-Y flap on KDPIF's outer arc shapes like a sail. Read More

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http://dx.doi.org/10.1002/jso.25879DOI Listing

A spindle cell squamous cell carcinoma on the cheek presenting with in-transit metastases and a satellite lesion.

Authors:
Eui-Tae Lee

Arch Craniofac Surg 2020 Feb 20;21(1):58-63. Epub 2020 Feb 20.

Department of Plastic and Reconstructive Surgery, Chungbuk National University College of Medicine, Cheongju, Korea.

Spindle cell squamous cell carcinoma (SpSCC) is a biphasic tumor composed of squamous cell epithelial and spindle cell mesenchymal components, both of which are malignant. Cutaneous SpSCC can cause diagnostic and therapeutic difficulties because of its rarity, heterogeneity, morphological similarity to other cutaneous spindle cell neoplasms, and uncertain pathogenesis and prognosis, particularly when the squamous cell carcinoma component is minimal or missing. Intransit metastasis and satellite lesion (satellitosis) constitute a spectrum of non-nodal regional metastases. Read More

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http://dx.doi.org/10.7181/acfs.2019.00654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054195PMC
February 2020

Quality of Life in Patients with Surgically Removed Skin Tumors.

Medicina (Kaunas) 2020 Feb 9;56(2). Epub 2020 Feb 9.

Department of Plastic and Reconstructive Surgery, Clinical Emergency Hospital "Prof. Dr. Agrippa Ionescu", Bucharest, 011356, Romania.

: Skin cancer is one of the most frequently diagnosed malignancies. The main goal of the therapeutic management is total excision with the prevention of recurrence and metastasis. The quality of life of the patients with skin cancer is affected by the morbidity risk, surgery, and cosmetic or functional aspects. Read More

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http://dx.doi.org/10.3390/medicina56020066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074335PMC
February 2020

Actinic Keratosis and Cutaneous Squamous Cell Carcinoma.

Dtsch Arztebl Int 2019 09;116(37):616-626

Skin Cancer Center Hannover, Department of Dermatology, Hannover Medical School; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Leipzig; Department of Radiotherapy, University Hospital Regensburg; Department of Oromaxillofacial, Plastic and Esthetic Surgery, Osnabrück Hospital GmbH, Osnabrück; Department of Dermatology and Allergology, University Hospital (LMU), Munich.

Background: Cutaneous squamous cell carcinoma (cSCC) and its precursors, actinic keratoses (AK), are common. Physicians of multiple specialties are confronted with their treatment.

Methods: This review is based on publications retrieved by a selective search in PubMed, as well as on the German guidelines on AK and cSCC, skin cancer prevention, and surgery with histologic guidance. Read More

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http://dx.doi.org/10.3238/arztebl.2019.0616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819699PMC
September 2019

Reconstruction following Excision of Malignant Scalp Tumors with Split Thickness Skin Graft with and without Acellular Dermal Matrix: A Comparative Study.

J Cutan Aesthet Surg 2019 Oct-Dec;12(4):203-211

Department of Plastic and Reconstructive Surgery, Tehran University of Medical Sciences, Imam Khomeini Hospital Complex, Tehran, Iran.

Background: Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most common malignancies, which occur on the scalp. There are various therapeutic methods for managing these malignancies in which the standard treatment method of both is surgical excision with a good margin. Sometimes, the patients need full-thickness excision due to the deep invasion, so exposing the underlying calvarium may be a challenge for surgeons. Read More

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http://dx.doi.org/10.4103/JCAS.JCAS_96_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6967162PMC
February 2020

[Interdisciplinary Management of Tumours of the Eyelid and Periorbital Region].

Klin Monbl Augenheilkd 2020 Jan 22;237(1):46-56. Epub 2020 Jan 22.

Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie, Universitätsklinikum Halle (Saale), Martin-Luther-Universität Halle-Wittenberg, Halle (Saale).

Introduction: Skin malignancies are typically localised in areas of the head that are exposed to the sun. Basal cell carcinomas (BCC) are the most frequent malignancies on the facial skin. Their incidence is raising - due to demographic changes. Read More

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http://dx.doi.org/10.1055/a-1082-1454DOI Listing
January 2020

Dual vascular free transverse rectus abdominis myocutaneous flap for hemifacial reconstruction in a vessel-depleted neck.

Arch Plast Surg 2020 Jan 15;47(1):88-91. Epub 2020 Jan 15.

Department of Plastic Surgery, Korea University College of Medicine, Seoul, Korea.

Cutaneous squamous cell carcinoma (SCC) is the second most common skin malignancy. This report describes the case of an unusual extensive SCC involving the whole hemiface, which required reconstruction with a combination of a dual vascular free transverse rectus abdominis muscle (TRAM) flap and a skin graft. A 79-year-old woman visited our hospital with multiple large ulcerated erythematous patches on her right hemiface, including the parieto-temporal scalp, bulbar and palpebral conjunctiva, cheek, and lip. Read More

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http://dx.doi.org/10.5999/aps.2019.00927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976761PMC
January 2020

'Dragon horn SCC'.

BMJ Case Rep 2019 Dec 29;12(12). Epub 2019 Dec 29.

Plastic Surgery, Countess of Chester Hospital, Chester, Cheshire West and Chester, UK.

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http://dx.doi.org/10.1136/bcr-2019-233305DOI Listing
December 2019

Facial cutaneous squamous cell carcinoma - microscopic safety margins and their impact on developing local recurrences.

J Craniomaxillofac Surg 2020 Jan 29;48(1):49-55. Epub 2019 Nov 29.

Department of Oral and Maxillofacial Surgery, Facial Plastic Surgery, University Medical Centre Mainz, Augustusplatz 2, 55131 Mainz, Germany.

Objectives: Surgical excision remains the treatment of choice for facial cutaneous squamous cell carcinoma (cSCC) despite there being no generally accepted diameter of clear margins. Therefore, the aim of this study was to evaluate the impact of microscopic clear margins diameter (mCMD) with respect to the development of local recurrences (LR).

Materials And Methods: The medical records of 99 patients with a total of 142 cases of facial cSCC, who underwent surgical treatment between January 2010 and December 2015, were reviewed for demographic data and clinicopathological features. Read More

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http://dx.doi.org/10.1016/j.jcms.2019.11.022DOI Listing
January 2020

Expression profile of sonic hedgehog signaling-related molecules in basal cell carcinoma.

PLoS One 2019 22;14(11):e0225511. Epub 2019 Nov 22.

Department of Pathology, Jeju National University College of medicine, Jeju, South Korea.

Basal cell carcinoma (BCC) is the most common human cancer, characterized by aberrant activation of the hedgehog (HH) signaling pathway resulting from mutations in the patched 1 (PTCH1) or smoothened (SMO) genes. In the present study, to uncover the expression profile of HH signaling-related molecules, we thoroughly examined the mRNA and protein expression levels of six molecules including GLI1, GLI2, PTCH1, PTCH2, SHH, and SMO in BCC and various other cutaneous tumors. Real-time PCR analysis demonstrated that BCC showed remarkably enhanced mRNA expression of all HH molecules, except SMO compared to other skin tumors. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0225511PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874381PMC

Complex regional pain syndrome as a paraneoplastic disorder associated with metatypical basal cell carcinoma.

Rom J Morphol Embryol 2019 ;60(2):685-689

Department of Plastic Surgery and Reconstructive Microsurgery, University of Medicine and Pharmacy of Craiova, Romania;

Metatypical basal cell carcinoma (MTBCC) is a rare form of tumor, which associates the clinical and histopathological (HP) characteristics of both basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), with a 5% chance for the development of metastases. The reference diagnosis remains the HP confirmation from the lesional tissue. The current report illustrates the case of a 74-year-old patient, diagnosed with MTBCC consequently to the biopsy from the clinically malignant lesion with HP and immunohistochemical examination, currently in clinical remission following surgical treatment. Read More

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March 2020
1 Read

Electrochemotherapy in Skin Malignancies of Head and Neck Cancer Patients: Clinical Efficacy and Aesthetic Benefits.

Acta Derm Venereol 2019 Dec;99(13):1246-1252

Department of Plastic and Reconstructive Surgery, San Gallicano Dermatological Institute, IRCCS, IT-00144 Rome, Italy.

Skin malignancies of the head and neck inflict significant structural, functional, and cosmetic burdens upon those affected. We retrospectively addressed electrochemotherapy anti-tumour efficacy in head and neck skin cancer patients who were not suitable for standard treatments. Scars' physical characteristics and aesthetics were evaluated using validated scar assessment scales. Read More

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http://dx.doi.org/10.2340/00015555-3341DOI Listing
December 2019
1 Read

Is Three-Dimensional Virtual Planning in Cranial Reconstruction for Advanced Cutaneous Squamous Cell Carcinoma of the Skull a Feasible Option?

J Craniofac Surg 2019 Nov-Dec;30(8):2362-2367

Academic Centre for Dentistry, University of Amsterdam.

Background: Cutaneous squamous cell carcinoma (cSCC) is a common type of malignant skin disorder. An uncommon feature is local bony invasion, as can rarely be seen in lesions on the scalp. The optimal treatment strategy in these rare cases is still under debate. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005895DOI Listing
January 2020
1 Read

A review of timelines for metastasis in cutaneous squamous cell carcinoma, and evidence for clinical follow-up.

J Plast Reconstr Aesthet Surg 2019 12 27;72(12):2064-2094. Epub 2019 Sep 27.

Department of Plastic and Reconstructive Surgery, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bjps.2019.09.017DOI Listing
December 2019

Split thickness skin graft in active psoriasis in patient with clear cell variant squamous cell carcinoma.

BMJ Case Rep 2019 Sep 16;12(9). Epub 2019 Sep 16.

Plastic Surgery, Townsville Hospital and Health Service, Townsville, Queensland, Australia.

The case report discusses split thickness skin grafting in a patient with active psoriasis. This also reports a case of a rare variant of squamous cell carcinoma. Read More

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http://dx.doi.org/10.1136/bcr-2019-231295DOI Listing
September 2019
1 Read

Reconstruction of a dorsal thoracic wall defect with a dorsal intercostal artery perforator flap after removal of a bulky cutaneous squamous cell carcinoma: a case report.

J Med Case Rep 2019 Sep 17;13(1):294. Epub 2019 Sep 17.

Department of Plastic Reconstructive Surgery and Burns, Rangueil University Hospital, 1 avenue du Professeur Jean Poulhès, 31400, Toulouse, France.

Introduction: Surgical reconstruction of large soft tissue defects of the upper back is challenging. Although the usefulness of free perforator flaps has been demonstrated, local options remain limited. The dorsal intercostal artery perforator flap was recently described but its use is still uncommon. Read More

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http://dx.doi.org/10.1186/s13256-019-2226-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747734PMC
September 2019
1 Read

Squamous cell carcinoma of the renal pelvis presenting as an integumentary neoplasm of the flank: A case report.

Medicine (Baltimore) 2019 Sep;98(36):e17049

Chonbuk National University, Biomedical Research Institute of Chonbuk National University Hospital, Research Institute of Clinical Medicine of Chonbuk National University, Department of Orthopedic Surgery.

Rationale: Although chronic pyelonephritis and urolithiasis are established risk factors for squamous cell carcinoma (SCC), only a minority of patients with chronic urolithiasis eventually develop SCC. It is believed that the chronic irritation leads to squamous cell metaplasia that may subsequently develop into SCC. Although studies show that SSC generally spreads locally with associated symptoms of lymphadenopathy, metastasis to the lungs and liver have also been reported. Read More

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http://dx.doi.org/10.1097/MD.0000000000017049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739005PMC
September 2019
3 Reads

Poorly differentiated cutaneous squamous cell carcinomas have high incomplete excision rates with UK minimum recommended pre-determined surgical margins.

J Plast Reconstr Aesthet Surg 2020 Jan 29;73(1):43-52. Epub 2019 Jul 29.

Department of Plastic Surgery, Cambridge University Hospitals NHS Trust, Cambridge CB2 0QQ, UK; Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK. Electronic address:

Background: In the UK, the British Association of Dermatology-British Association of Plastic, Reconstructive and Aesthetic Surgery (BAD-BAPRAS) guidelines recommend excision of high-risk cutaneous squamous cell carcinomas (cSCCs), including poorly differentiated cSCCs, with a minimum peripheral margin of 6 mm.

Objectives: We assess whether the BAD-BAPRAS minimum margin achieves histological clearance in poorly differentiated cSCCs.

Patients And Methods: Demographics, surgical notes and histological reports from all patients having a primary cSCC excised at the Plastic Surgery Department of Addenbrooke's Hospital, Cambridge, UK, between January 2017 and April 2018 were analysed. Read More

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http://dx.doi.org/10.1016/j.bjps.2019.06.034DOI Listing
January 2020

Oncodermatology of the Head and Neck.

Facial Plast Surg 2019 Aug 30;35(4):368-376. Epub 2019 Aug 30.

Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.

The European Academy of Facial Plastic Surgery celebrates its 40th anniversary. We aimed to describe innovations in the diagnostics and treatment in head and neck skin cancer over the past 40 years as well as future perspectives. Landmark events, developments, and highlights over the past decades for basal cell carcinoma, cutaneous squamous cell carcinoma, and melanoma are discussed. Read More

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http://dx.doi.org/10.1055/s-0039-1695044DOI Listing
August 2019
4 Reads

Reply: Current Basal and Squamous Cell Skin Cancer Management.

Plast Reconstr Surg 2019 09;144(3):521e-522e

Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1097/PRS.0000000000005976DOI Listing
September 2019

Current Basal and Squamous Cell Skin Cancer Management.

Plast Reconstr Surg 2019 09;144(3):520e-521e

Division of Plastic Surgery, Penn State Milton S. Hershey Medical Center, Hershey, Pa.

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http://dx.doi.org/10.1097/PRS.0000000000005975DOI Listing
September 2019

Downregulation of kynureninase restrains cutaneous squamous cell carcinoma proliferation and represses the PI3K/AKT pathway.

Clin Exp Dermatol 2020 Mar 26;45(2):194-201. Epub 2019 Sep 26.

Department of, Burn and Plastic Surgery, First Affiliated Hospital of Wannan Medical College, Wuhu, China.

Background: The protein kynureninase (KYNU) has recently been reported to participate in the pathological processes of various diseases.

Aim: To explore the expression and the biological function of KYNU in cutaneous squamous cell carcinoma (cSCC).

Methods: Expression of KYNU in cSCC cell lines and tissues was firstly evaluated based on the Gene Expression Omnibus and the Oncomine databases. Read More

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http://dx.doi.org/10.1111/ced.14072DOI Listing

Clinical Characteristics and Outcome of Malignant Eyelid Tumors: A Five-Year Retrospective Study.

Med Arch 2019 Jun;73(3):209-212

Clinic for Ophthalmology, University Clinical Center Tuzla, Bosnia and Herzegovina.

Introduction: To the best of our knowledge, this is the first study about malignant eyelid tumors in the region of Tuzla, Bosnia and Herzegovina, and it shows similar results comparing with other countries (the annual incidence of eyelid tumors in Tuzla region is about 3.73/100 000 population). Malignant eyelid tumors are relatively uncommon, but potentially fatal disease. Read More

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http://dx.doi.org/10.5455/medarh.2019.73.209-212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643352PMC
June 2019
12 Reads

Oncological and aesthetic outcome following surgical management of orbito-palpebral skin cancers: A retrospective study of 132 patients.

J Craniomaxillofac Surg 2019 Oct 16;47(10):1577-1582. Epub 2019 Jul 16.

Department of Plastic, Reconstructive and Maxillo-Facial Surgery, Henri-Mondor Hospital, AP-HP, Creteil, France.

Background: The incidence of facial skin cancers continues to rise, with major studies on their impacts still lacking in the literature. This study reports on the oncological and aesthetic results following surgical management of an orbito-palpebral skin cancer.

Methods: This retrospective, monocentric study included patients treated for a non-melanoma skin cancer of the eyelid and orbit. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10105182193034
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http://dx.doi.org/10.1016/j.jcms.2019.07.015DOI Listing
October 2019
2 Reads

Comment on `The detection rate of human papillomavirus in well-differentiated squamous cell carcinoma and keratoacanthoma: is there new evidence for a viral pathogenesis of keratoacanthoma?' - reply from authors.

Br J Dermatol 2019 12 15;181(6):1345-1346. Epub 2019 Oct 15.

Dermatology Clinic, Maggiore Hospital, Piazza dell'Ospitale 1, University of Trieste, Trieste, Italy.

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http://dx.doi.org/10.1111/bjd.18385DOI Listing
December 2019
12 Reads

A Rare Transformation of Epidermoid Cyst into Squamous Cell Carcinoma: A Case Report with Literature Review.

Am J Case Rep 2019 Aug 3;20:1141-1143. Epub 2019 Aug 3.

Department of Surgery, Division of Plastic and Reconstructive Surgery, Marshall University, Huntington, WV, USA.

BACKGROUND Epidermoid cysts are the most common benign skin lesions that can occur anywhere on the body, and frequently occur on the face, scalp, neck, and trunk. Typically, patients are asymptomatic, and the lesions present as firm skin-colored nodules filled with keratinous or sebaceous materials that are formed by cystic expansion of the epidermal epithelium. Malignant transformation is rare in epidermoid cysts. Read More

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http://dx.doi.org/10.12659/AJCR.912828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690212PMC
August 2019
6 Reads

Quality of life and clinical and demographic characteristics of patients with cutaneous squamous cell carcinoma submitted to tumor resection by double-bladed scalpel.

An Bras Dermatol 2019 Jul 29;94(3):304-312. Epub 2019 Jul 29.

Department of Clinical Medicine, Universidade Federal de Santa Catarina (SC), Brazil.

Background: Non-melanoma skin cancer accounts for a third of all malignancies registered in Brazil, with squamous cell carcinoma (SCC) being one of its subtypes. It develops in photo-exposed areas, affecting social habits and causing negative influence on quality of life (QoL).

Objectives: To evaluate QoL in patients with primary cutaneous SCC. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20197842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668942PMC
July 2019
3 Reads

Acellular Dermal Matrix Mistaken as Recurrence of Malignancy Following Surgery on Positron Emission Tomography/Computed Tomography: A Case Report.

Ann Otol Rhinol Laryngol 2019 Dec 27;128(12):1189-1193. Epub 2019 Jul 27.

Department of Otorhinolaryngology and Biomedical Research Institute, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea.

Objectives: To report a rare clinical presentation of an acellular dermal matrix (ADM) used during lateral temporal bone resection mimicking recurrence of cancer of external auditory canal (EAC) on positron emission tomography/computed tomography (PET/CT) 9 months after surgery.

Methods: Case report and literature review.

Results: A 71-year-old woman underwent lateral temporal bone resection 9 months earlier for management of squamous cell carcinoma of the EAC. Read More

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http://dx.doi.org/10.1177/0003489419863448DOI Listing
December 2019

The "Bat Flap": A flap for reconstruction of large skull skin defects.

J Plast Reconstr Aesthet Surg 2019 Nov 5;72(11):1856-1871. Epub 2019 Jul 5.

Dermatology Unit, Modena and Reggio Emilia University, Modena, Italy.

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http://dx.doi.org/10.1016/j.bjps.2019.06.007DOI Listing
November 2019
2 Reads

Defining skin cancer local recurrence.

J Am Acad Dermatol 2019 Aug;81(2):581-599

Department of Dermatology and Skin Science, University of British Columbia, Vancouver, Canada.

Definitions of skin cancer recurrence are variable and nonstandardized, which can lead to inconsistent and potentially inappropriate management of tumors of uncertain recurrence status. Defining recurrence is important given the potential association with metastasis in both melanoma and nonmelanoma skin cancer. A review of the literature across multiple disciplines involved in the care of skin cancer patients reveals that although criteria for recurrence are provided in the majority of cases, most are vague and inconsistent. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.03.087DOI Listing
August 2019
1 Read

Squamous cell carcinoma arising in a chronic leg ulcer in Klippel-Trenaunay syndrome after the Charles procedure: A case with 40 years of follow up.

J Dermatol 2019 Nov 8;46(11):e403-e405. Epub 2019 Jul 8.

Department of Plastic and Reconstructive Surgery, Center for Vascular Anomalies, Tonan Hospital, Sapporo, Japan.

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http://dx.doi.org/10.1111/1346-8138.15001DOI Listing
November 2019

Tumor Depth of Invasion (Tumor > 4 cm/Depth > 10 mm and Depth > 20 mm) and Through Cortex/Skin Invasion are Both Valid Criteria for Classifying Tumors as pT4a in AJCC 2018 Oral Cavity Cancer Staging System.

Ann Surg Oncol 2019 Oct 1;26(11):3663-3672. Epub 2019 Jul 1.

Department of Head and Neck Oncology Group, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyüan, Taiwan, ROC.

Background: According to the AJCC third to seventh edition staging manuals (1988-2010), the presence of through cortex and/or skin invasion in oral cavity squamous cell carcinoma (OCSCC) identifies T4a tumors. The AJCC eighth edition (2018) introduced a depth of invasion (DOI) > 20 mm as a criterion for pT4a. Subsequently, a revision maintained that tumors > 4 cm with a DOI > 10 mm should be classified as pT4a. Read More

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http://dx.doi.org/10.1245/s10434-019-07576-5DOI Listing
October 2019
6 Reads

Extended Central Artery Perforator Propeller Flap for Large Nasal Defects.

J Craniofac Surg 2019 Nov-Dec;30(8):2408-2411

Ankara Oncology Training and Research Hospital, Department of Plastic Reconstructive and Aesthetic Surgery, Ankara, Turkey.

Various local flaps have been defined for small skin defects of the nose. However, the repair of large nasal defects is only possible with flaps allowing a large tissue transfer, such as a free flap, forehead flap, and nasolabial flap. In this study, large nasal defects were reconstructed with extended central artery perforator propeller (CAPP) flaps in an attempt to describe a single-stage procedure as an alternative technique to the median forehead flap. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005672DOI Listing
January 2020
13 Reads

Could EMA and cytokeratin 7 be useful in distinguishing tricholemmal carcinoma from clear-cell squamous cell carcinoma? A case series from our department and a brief review of the literature.

Acta Histochem 2019 Aug 21;121(6):765-767. Epub 2019 Jun 21.

Pathology Unit, S.Orsola Malpighi Hospital, Bologna University, Bologna, Italy.

Tricholemmal carcinoma is a malignant cutaneous adnexal tumor showing outer root sheath differentiation, thought to be the malignant counterpart of trichilemmoma. Although the real existence of tricholemmal carcinoma continues to be a matter of debate, it has been introduced in the recently published 4th edition of World Health Organization classification of skin tumors. Herein, we evaluated whether immunohistochemistry (EMA, CK7, CK5/14, p63, p16, and Ber-EP4) supports tricholemmal carcinoma as a separate entity and whether it could be useful in this differential diagnosis. Read More

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http://dx.doi.org/10.1016/j.acthis.2019.06.002DOI Listing
August 2019
7 Reads

Advances in Immunotherapy and Periocular Malignancy.

Semin Ophthalmol 2019 9;34(4):327-333. Epub 2019 Jun 9.

a Ophthalmic Plastic Surgery , Massachusetts Eye and Ear Infirmary , Boston , MA , USA.

Immunotherapy has significantly advanced the field of oncology in recent decades. Understanding normal immunosurveillance, as well as the ways in which tumor cells have evolved to evade it, has provided the knowledge for development of drugs that allow one's own immune system to target and destroy malignant cells (immunotherapy). Cutaneous malignancies are particularly sensitive to this class of drugs. Read More

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http://dx.doi.org/10.1080/08820538.2019.1620813DOI Listing
July 2019
8 Reads
1.196 Impact Factor

Reverse-supercharged, distally based latissimus dorsi flap for lumbar defect: A case report.

Microsurgery 2019 Jul 7;39(5):452-456. Epub 2019 May 7.

Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science, Okayama, Japan.

Well-vascularized tissue is required for successful reconstruction of a soft tissue defect in the lumbar region. There are several options for reconstruction; however, controversy exists regarding the optimal technique. Here, we present a case of a lumbar defect following tumor resection in a 75-year-old patient that was repaired using a reverse-supercharged, distally based latissimus dorsi flap. Read More

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http://dx.doi.org/10.1002/micr.30467DOI Listing
July 2019
4 Reads

Estimating the health care costs of non-melanoma skin cancer in Saskatchewan using physician billing data.

Curr Oncol 2019 04 1;26(2):114-118. Epub 2019 Apr 1.

Saskatchewan Cancer Agency, Saskatoon, SK.

Introduction: Given the high occurrence and morbidity of non-melanoma skin cancer (nmsc), its economic burden on the Canadian health care system is a cause for concern. Despite that relevance, few studies have used patient-level data to calculate the cost of nmsc. The objective of the present study was to use physician billing data to describe the health care costs and service utilization associated with nmsc in Saskatchewan. Read More

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http://dx.doi.org/10.3747/co.26.4557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476453PMC
April 2019
3 Reads

Keratinocyte cancer excisions in Australia: Who performs them and associated costs.

Australas J Dermatol 2019 Nov 22;60(4):294-300. Epub 2019 Apr 22.

Department of Population Health, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.

Background/objective: To describe the clinical settings in which keratinocyte cancers are excised in Queensland and describe the types of practitioners who excise them; to examine costs; and to identify predictors of hospital admission.

Methods: We used linked data for participants from the QSkin study (n = 43 794), including Medicare claims and Queensland hospital admissions relating to treatment episodes for incident keratinocyte cancers from July 2011 to June 2015. We used multinomial logistic regression to measure associations between demographic and clinical characteristics and treatment setting. Read More

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http://dx.doi.org/10.1111/ajd.13056DOI Listing
November 2019
4 Reads

USF1-induced upregulation of LINC01048 promotes cell proliferation and apoptosis in cutaneous squamous cell carcinoma by binding to TAF15 to transcriptionally activate YAP1.

Cell Death Dis 2019 04 1;10(4):296. Epub 2019 Apr 1.

Guangzhou Institute of Dermatology, Institute of Dermatology, Guangzhou Medical University, No.56 Hengfu Road, Guangzhou, 510095, Guangdong, China.

Previous studies have revealed that dysregulation of long non-coding RNAs (lncRNAs) can facilitate carcinogenesis. This study aims to investigate the biological role of a certain lncRNA in cutaneous squamous cell carcinoma (CSCC). According to the data of TCGA database, high expression of long intergenic non-protein coding RNA 1048 (LINC01048) is an unfavorable prognostic factor for patients with CSCC. Read More

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http://dx.doi.org/10.1038/s41419-019-1516-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443651PMC
April 2019
3 Reads
5.014 Impact Factor

Massive Periocular Squamous Cell Carcinoma With Response to Pembrolizumab (Keytruda).

Ophthalmic Plast Reconstr Surg 2019 Sep/Oct;35(5):e127

Oculofacial Plastic and Orbital Surgery, Gavin Herbert Eye Institute University of California, Irvine, California, U.S.A.

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http://dx.doi.org/10.1097/IOP.0000000000001351DOI Listing
January 2020

miRNA-221 promotes cutaneous squamous cell carcinoma progression by targeting PTEN.

Cell Mol Biol Lett 2019 8;24. Epub 2019 Mar 8.

Department of Burn and Plastic Surgery, The First People's Hospital of Nantong, Nantong, 226001 China.

Background: Cutaneous squamous cell carcinoma (CSCC) is a common type of skin malignancy. MicroRNA-221 (miRNA-221) is a critical non-coding RNA in tumor initiation and progression. However, the molecular mechanisms of miRNA-221 in the development of CSCC remain unknown. Read More

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http://dx.doi.org/10.1186/s11658-018-0131-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407258PMC
April 2019
7 Reads

Autologous Skin-Grafting Surgery to Prevent Esophageal Stenosis After Complete Circular Endoscopic Submucosal Tunnel Dissection for Superficial Esophageal Neoplasms.

Am J Gastroenterol 2019 05;114(5):822-825

Department of Gastroenterology, Chinese PLA General Hospital, Beijing, China.

Objectives: To assess the safety and effectiveness of autologous skin-grafting surgery (ASGS) for preventing esophageal stenosis after complete circular endoscopic submucosal tunnel dissection (ccESTD) for superficial esophageal neoplasms.

Methods: Between October 2017 and March 2018, 8 patients who underwent ccESTD and ASGS were included. We assessed the occurrence of esophageal stenosis and adverse events. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000169DOI Listing
May 2019
4 Reads

Helical Rim Reconstruction With Chondrocutaneous Hatchet Flap-Z Plasty.

Ann Plast Surg 2019 05;82(5):533-536

Department of Plastic, Reconstructive and Aesthetic Surgery, University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.

Background: Helical rim reconstruction is relatively difficult because of the unique anatomical structure of the ear. The aesthetic and functional characteristics of the ear make such reconstruction even more important. This article presents the newly defined chondrocutaneous hatchet flap-Z plasty (HFZP) method in helical rim defects and evaluates the results. Read More

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http://dx.doi.org/10.1097/SAP.0000000000001774DOI Listing
May 2019
5 Reads

PDGFR-induced autocrine SDF-1 signaling in cancer cells promotes metastasis in advanced skin carcinoma.

Oncogene 2019 06 15;38(25):5021-5037. Epub 2019 Mar 15.

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.

Advanced and undifferentiated skin squamous cell carcinomas (SCCs) exhibit aggressive growth and enhanced metastasis capability, which is associated in mice with an expansion of the cancer stem-like cell (CSC) population and with changes in the regulatory mechanisms that control the proliferation and invasion of these cells. Indeed, autocrine activation of PDGFRα induces CSC invasion and promotes distant metastasis in advanced SCCs. However, the mechanisms involved in this process were unclear. Read More

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http://dx.doi.org/10.1038/s41388-019-0773-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756210PMC
June 2019
17 Reads

Large single cutaneous metastasis of colon adenocarcinoma mimicking a squamous cell carcinoma of the skin: A case report.

Int J Surg Case Rep 2019 7;56:96-100. Epub 2019 Mar 7.

Multidisciplinary Department of Medical and Dental Specialties, Università degli Studi della Campania "Luigi Vanvitelli", Plastic Surgery Unit, Naples, Italy.

Introduction: Metastases represent one of the most outstanding characteristics of malignant neoplasms and are relatively rare in the skin, in spite of the great extension of the cutaneous organs. Development of cutaneous metastases from colon cancer is a rare event, usually occurring in widely disseminated disease and commonly leading to a poor prognosis. As to location, cutaneous metastases often favor areas close to the primary malignancy, such as lung cancer and skin metastases on the trunk. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612193010
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http://dx.doi.org/10.1016/j.ijscr.2019.02.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424055PMC
March 2019
31 Reads

Validation Study of the AJCC Cancer Staging Manual, Eighth Edition, Staging System for Eyelid and Periocular Squamous Cell Carcinoma.

JAMA Ophthalmol 2019 05;137(5):537-542

Orbital Oncology and Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston.

Importance: To our knowledge, there are no validation studies to date of the prognostic value of the AJCC Cancer Staging Manual, eighth edition (AJCC 8), criteria for eyelid and periocular squamous cell carcinoma.

Objective: To determine the association of tumor (T) category in AJCC 8 with local recurrence, nodal metastasis, distant metastasis, and disease-specific survival (DSS) for eyelid and periocular squamous cell carcinoma.

Design, Setting, And Participants: In this retrospective, single-center cohort study, 109 consecutive patients with eyelid and periocular squamous cell carcinoma treated from January 1999 to April 2018 were included. Read More

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http://dx.doi.org/10.1001/jamaophthalmol.2019.0238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512305PMC
May 2019
7 Reads

Epidemiology and natural history of cutaneous squamous cell carcinoma in recessive dystrophic epidermolysis bullosa patients: 20 years' experience of a reference centre in Spain.

Clin Transl Oncol 2019 Nov 12;21(11):1573-1577. Epub 2019 Mar 12.

Department of Dermatology, La Paz University Hospital, Madrid, Spain.

Background: Cutaneous squamous cell carcinoma (cSCC) is the leading cause of death in patients with recessive dystrophic epidermolysis bullosa (RDEB). We provide the management and prognosis of cSCC in RDEB patients at a Spanish reference center.

Materials And Methods: We retrospectively included patients with RDEB attended in La Paz University Hospital from November 1988 to October 2018. Read More

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http://dx.doi.org/10.1007/s12094-019-02073-3DOI Listing
November 2019
1 Read