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Crit Rev Oncol Hematol 2022 Jun 22:103751. Epub 2022 Jun 22.

Molecular Cancer Genetics & Translational Research Lab, Section of Genetics, Department of Zoology, Aligarh Muslim University, Aligarh-202002, India. Electronic address:

Background: Apigenin is being increasingly recognized as a cancer chemopreventive agent. We aimed to investigate the anticancer effects of Apigenin in in-vivo studies to know its present research status and how close or how far it is from the clinics.

Methods: Several electronic databases such as PubMed, Springer, Cochrane, and ctri. Read More

Int J Biol Macromol 2022 Jun 22. Epub 2022 Jun 22.

Department of Bioproducts and Biosystems Engineering, University of Minnesota, St Paul, MN 55108, USA.

The formidable virulence of methicillin-resistant staphylococcus aureus (MRSA) have thrown great challenges to biomedicine, which mainly derives from their autocrine phenol-soluble modulins (PSMs) toxins, especially the most toxic member termed phenol-soluble modulins α3 (PSMα3). PSMα3 cytotoxicity is attributed to its amyloidal fibrillation and subsequent formation of cross-α sheet fibrils. Inspired by the multiple biological activity of Sappanwood, herein, we adopted brazilin, a natural polyphenolic compound originated from Caesalpinia sappan, as a potential antidote of PSMα3 toxins, and attempted to prove that the regulation of PSMα3 fibrillation was an effective alexipharmic way for MRSA infections. Read More

J Invest Dermatol 2022 Jun 22. Epub 2022 Jun 22.

Department of Dermatology, Keio University School of Medicine, Tokyo, Japan; Laboratory for Skin Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. Electronic address:

TMEM79 is a predisposing gene for atopic dermatitis (AD). Tmem79-deficient mice develop spontaneous dermatitis in a biphasic pattern. The 1-phase dermatitis is unique, as it occurs independent of microbiota status, whereas the 2-phase dermatitis is microbiota-dependent. Read More

J Am Acad Dermatol 2022 Jun 22. Epub 2022 Jun 22.

Department of Human-Computer Interaction, Hanyang University, Seoul, South Korea.

Background: Although various skin cancer detection devices have been proposed, most of them are not used owing to their insufficient diagnostic accuracies. Laser-induced plasma spectroscopy (LIPS) can noninvasively extract biochemical information of skin lesions using an ultrashort pulsed laser.

Objective: To investigate the diagnostic accuracy and safety of a real-time noninvasive in vivo skin cancer diagnostics utilizing non-discrete molecular LIPS combined with a deep neural network (DNN)-based diagnostic algorithm. Read More

J Am Acad Dermatol 2022 Jun 22. Epub 2022 Jun 22.

Department of Dermatology, Weill Cornell Medicine New York, NY, USA. Electronic address:

Background: Longitudinal melanonychia (LM) is a common dermatologic finding in clinical practice with a broad differential diagnosis. Melanocytic activation is the most common LM etiology.

Objective: To investigate clinical and dermoscopic differences of benign LM based on Fitzpatrick skin type and in biopsied vs. Read More

J Ethnopharmacol 2022 Jun 22:115499. Epub 2022 Jun 22.

College of Animal Sciences (College of Bee Science), Fujian Agriculture and Forestry University, Fuzhou, 350002, China; College of Marine Sciences, Fujian Agriculture and Forestry University, Fuzhou, 350002, China. Electronic address:

Ethnopharmacological Relevance: According to the Compendium of Materia Medica, honey has been used as a traditional medicine in treatment against mucositis, tinea, hemorrhoids and psoriasis. In complementary medicine, due to its significant antimicrobial activity, honey has been widely used as a remedy for skin wounds and gastrohelcosis for thousands of years.

Aim Of The Study: This study is aimed at exploring the antimicrobial activity and mechanisms of honey sourced from medical plants, and revealing the composition-activity relationship, to facilitate their complementary and alternative application in the therapy of bacterial infectious diseases. Read More

Biochimie 2022 Jun 22. Epub 2022 Jun 22.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, I.R. Iran. Electronic address:

Combination chemotherapy seems to be a beneficial choice for some cancer patients particularly when the drugs target different processes of oncogenesis; patients treated with combination therapies sometimes have a better prognosis than those treated with single drug chemotherapy. However, research has shown that this is not always the case, and this approach may only increase toxicity without having a significant effect in augmenting the antitumor actions of the drugs. Doxorubicin (Dox) is one of the most common chemotherapy drugs used to treat many types of cancer, but it also has serious side effects, such as cardiotoxicity, skin necrosis, testicular toxicity, and nephrotoxicity. Read More

Acta Trop 2022 Jun 22:106570. Epub 2022 Jun 22.

National Reference Laboratory for Plague, Tularemia and Q fever, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Akanlu, Kabudar Ahang, Hamadan, Iran; Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Tehran, Iran. Electronic address:

Background: Tularemia is a zoonotic disease that has been reported in many countries of the Northern Hemisphere. However, in some countries, such as Iran, this disease has been neglected by the health care system, and it is under-reported.

Case Presentation: Here we report an unusual case of ulceroglandular tularemia occurring in a 35-year-old woman who presented with a skin lesion of the left flank, inguinal lymphadenopathy, and an abdominal abscess. Read More

Am J Perinatol 2022 Jun 25. Epub 2022 Jun 25.

Department of Obstetrics and Gynecology and Reproductive Sciences, University of Maryland Medical Center, Baltimore, United States.

Objective To evaluate if supraumbilical midline vertical incision performed in patients with a hanging pannus (umbilicus at the level of the pubic bone) is a reasonable alternative to Pfannenstiel in patients with Body Mass Index (BMI) ≥ 50 kg/m2 undergoing cesarean delivery. Methods Retrospective cohort study in patients with BMI ≥50 kg/m2 undergoing cesarean delivery at a single center from 2016 to 2020. Study groups were Pfannenstiel VS supraumbilical vertical skin incision. Read More

Facial Plast Surg 2022 Jun 25. Epub 2022 Jun 25.

Plastic Surgery, Plastic Surgery, Thessaloniki, Greece.

There is a need for a specialist pathway or progression in aesthetic medicine for aesthetic physicians. A structured program for specialised training in non-surgical facial aesthetics to empower physicians is the need of the hour. The pharmaceutical companies currently provide training sessions, taking considerable initiatives to train aesthetic professionals. Read More

Phytomedicine 2022 Jun 15;104:154250. Epub 2022 Jun 15.

Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan. Electronic address:

Background: Parkinson's disease (PD) is a neurodegenerative disorder involving the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Cellular clearance mechanisms, including the autophagy-lysosome pathway, are commonly affected in the pathogenesis of PD. The lysosomal Ca channel mucolipin TRP channel 1 (TRPML1) is one of the most important proteins involved in the regulation of autophagy. Read More

Mar Environ Res 2022 Jun 16;179:105687. Epub 2022 Jun 16.

National Institute of Oceanography and Fisheries, NIOF, Egypt.

This study comparing the expected pollution status of phenol along with heavy metals in sediments of two economic regions on the Mediterranean Sea coast using equilibrium partitioning method (EPM) as well as exposure of fishermen and populations to these sediments through ingestion and skin contact while swimming. El-Dekhila (ED) and Abu Talat (AT) regions were different in sediment texture and pollution sources. The expected ecological hazards of phenol in the studied areas were carried out using the equilibrium partitioning method (EPM) by which the partition coefficient of organic carbon-water, K (logK> 0. Read More

Gen Hosp Psychiatry 2022 Jun 16;78:9-13. Epub 2022 Jun 16.

Center for Psychotherapy Research, University Hospital Heidelberg, Heidelberg, Germany.

Objective: Although traumatic stress including childhood maltreatment (CM) has a profound impact on mental health, its relation to pathological skin picking (PSP) has been understudied and results remain inconclusive. Likewise, posttraumatic stress disorder (PTSD) as the most typical sequelae of traumatic stress has hardly been investigated in those with PSP. The objective of our online case-control study was to shed further light on this issue. Read More

Int J Surg Case Rep 2022 Jun 21;96:107339. Epub 2022 Jun 21.

Department of General Surgery, Kilimanjaro Christian Medical Centre, P O Box 3010, Moshi, Tanzania; Kilimanjaro Christian Medical University College, Faculty of Medicine, P O Box 2240, Moshi, Tanzania.

Introduction And Importance: The superficial circumflex iliac artery perforator flap is a widely used and acceptable option of free tissue transfer for small and large defects due to its ease of dissection and adjustable pedicle length.

Case Presentation: Herein we present our experience with two similar cases of hand ulcers with differing aetiologies that were managed successfully at our tertiary centre by general surgeons to cover the defects in order to salvage the hand.

Clinical Discussion: The pedicle groin flap was first described in 1972 and still indicated and used widely in hand resurfacing. Read More

Ultrasound Obstet Gynecol 2022 Jun 25. Epub 2022 Jun 25.

The Fetal Center, Children's Memorial Hermann Hospital, Department of Obstetrics and Gynecology, McGovern Medical School, The University of Texas Health Science Center at Houston, Texas, USA.

Objectives: In-utero spina bifida closure of large defects is often challenging, requiring tissue graft for watertight skin closure. No prior studies have compared the primary skin closure with the patch-based repair. Our objective was to compare neonatal and one-year outcomes associated with these two types of skin closure for in-utero spina bifida repair. Read More

J Clin Endocrinol Metab 2022 Jun 25. Epub 2022 Jun 25.

Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia.

Context: the majority of cases of epithelial cell-derived thyroid cancer are sporadic. Familial non-medullary thyroid cancer (FNMTC) occurs in about 5-9% of cases, either as a part of known syndromes such as Cowden syndrome or in the form of familial clustering of 2 or more affected family members. Hereditary Leiomyoma and renal cell cancer (HLRCC) syndrome is a rare familial cancer syndrome. Read More

J Dermatol 2022 Jun 25. Epub 2022 Jun 25.

Department of Dermatology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.

Systemic sclerosis (SSc) is an autoimmune disease characterized by skin and lung fibrosis. Over 90% of patients with SSc are positive for autoantibodies. In addition, the serum levels of B-cell activating factor, a potent B-cell stimulator, are correlated with SSc severity and activity. Read More

J Dermatol 2022 Jun 25. Epub 2022 Jun 25.

Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

As autoimmune skin diseases, both bullous pemphigoid (BP) and dermatomyositis (DM) show significant associations with the major histocompatibility complex (MHC) region. In fact, the coexistence of BP and DM has been previously reported. Therefore, we hypothesized that there may be a potential genetic correlation between BP and DM. Read More

Int J Biometeorol 2022 Jun 25. Epub 2022 Jun 25.

College of Fashion and Design, Donghua University, West Yan'an Road 1882, Shanghai, 200051, China.

The thermo-physiological human simulator has been used in many regions for estimating thermal behavior of the locals. The applicability of the human simulator to populations from different regions is, however, questioned due to its lack of consideration for the ethnic diversities in thermoregulation. This study checked the potential of improving the applicability of the Newton human simulator, one of the most popular simulators, by correcting its local set point skin temperatures according to the target population (Chinese as an example). Read More

Pharmacoepidemiol Drug Saf 2022 Jun 25. Epub 2022 Jun 25.

Netherlands Pharmacovigilance Centre Lareb, 's Hertogenbosch, the Netherlands.

Background: Adverse drug reaction (ADR) reports in pharmacovigilance databases often contain coded information and large amounts of unstructured or semi-structured information in plain text format. The unstructured format and sheer volume of these data often render them neglected. Structural topic modelling (STM) represents a potentially insightful way of harnessing these valuable data and to detect grouping or themes in spontaneous reports to aid signal detection. Read More

Rheumatology (Oxford) 2022 Jun 25. Epub 2022 Jun 25.

Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Lebanon, NH, 03756, USA.

Objectives: Four intrinsic molecular subsets (Inflammatory, Fibroproliferative, Limited, Normal-like) have previously been identified in systemic sclerosis (SSc) and are characterized by unique gene expression signatures and pathways. The intrinsic subsets have been linked to improvement with specific therapies. Here, we investigated associations between baseline demographics and intrinsic molecular subsets in a meta-analysis of published datasets. Read More

Exp Dermatol 2022 Jun 25. Epub 2022 Jun 25.

Division of Dermatology, Department of Internal Related, Graduate School of Medicine, Kobe University, Kobe, Japan.

Non-melanoma skin cancer (NMSC) is mainly caused by ultraviolet (UV)-induced somatic mutations and is characterized by UV signature modifications. Xeroderma pigmentosum group A (Xpa) knockout mice exhibit extreme UV-induced photo-skin carcinogenesis, along with a photosensitive phenotype. We performed whole-exome sequencing (WES) of squamous cell carcinoma (SCC) samples after repetitive ultraviolet B (UVB) exposure to investigate the differences in the landscape of somatic mutations between Xpa knockout and wild-type mice. Read More

Acta Dermatovenerol Alp Pannonica Adriat 2022 Jun;31(2):89-92

Department of Infectious Diseases, University Medical Center Maribor, Maribor, Slovenia.

Tularemia, or rabbit fever, is a zoonotic infection caused by Francisella tularensis, a Gram-negative coccobacillus. F. tularensis subsp. Read More

Acta Dermatovenerol Alp Pannonica Adriat 2022 Jun;31(2):83-87

Department of Dermatovenereology, University Medical Centre Ljubljana, Ljubljana, Slovenia.

Cutaneous vasculitis is a recognized and potentially serious adverse event of immunization with several vaccines, and COVID-19 vaccines are no exception. We present a case of cutaneous leukocytoclastic vasculitis occurring 17 days after inoculation with adenoviral vector vaccine (Ad26.COV2. Read More

J Med Radiat Sci 2022 Jun 25. Epub 2022 Jun 25.

Radiation Oncology Princess Alexandra Hospital - Ipswich Road, Brisbane, Queensland, Australia.

Introduction: Anal canal cancer (ACC) is uncommon. The gold standard of care is chemoradiotherapy treatment. However, this treatment is associated with considerable acute and late side effects. Read More

J Cosmet Dermatol 2022 Jun 25. Epub 2022 Jun 25.

Clinical Research Development Center, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Melasma is a chronic and acquired pigmentary condition that primarily affects women and undermines patient satisfaction and confidence. Melasma mostly affects females, accounting for 90% of all cases. It affects people of all races, particularly those with skin types IV and V who live in areas with lots of UV radiation. Read More

Acta Dermatovenerol Alp Pannonica Adriat 2022 Jun;31(2):89-92

Department of Dermatovenereology, University Medical Centre Ljubljana, Ljubljana, Slovenia.

Cutaneous vasculitis is a recognized and potentially serious adverse event of immunization with several vaccines, and COVID-19 vaccines are no exception. We present a case of cutaneous leukocytoclastic vasculitis occurring 17 days after inoculation with adenoviral vector vaccine (Ad26.COV2. Read More

Acta Dermatovenerol Alp Pannonica Adriat 2022 Jun;31(2):83-87

Department of Infectious Diseases, University Medical Center Maribor, Maribor, Slovenia.

Tularemia, or rabbit fever, is a zoonotic infection caused by Francisella tularensis, a Gram-negative coccobacillus. F. tularensis subsp. Read More

Acta Dermatovenerol Alp Pannonica Adriat 2022 Jun;31(2):79-81

Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Strongyloides stercoralis causes chronic, mostly asymptomatic infections but hyperinfection syndrome may occur in immunosuppressed patients, especially in those receiving corticosteroids. We report a case of S. stercoralis hyperinfection syndrome in a solid organ transplant recipient that occurred approximately 2. Read More

Acta Dermatovenerol Alp Pannonica Adriat 2022 Jun;31(2):75-77

Department of Dermatology and Venereology, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey.

Transit metastases include metastatic foci of the skin and subcutaneous tissue located between the tumor and the nearest regional lymph node. Although transit metastases have been described for malignant melanoma, some cases of transit metastases have also been reported among primary cutaneous non-melanoma cancers. Treatment of patients with in-transit squamous cell carcinoma (SCC) is a multimodal approach for advanced staging imaging and therapy, including Mohs micrographic surgery, adjuvant radiation, and possibly sentinel lymph node biopsy and immunotherapy or chemotherapy. Read More