807,192 results match your criteria Skin Malignancies Merkel Cell Carcinoma and Rare Appendageal Tumors* Plastic Surgery


A novel ablative radiofrequency (RF) microplasma non-surgical blepharoplasty for dermatochalasis.

Dermatol Ther 2020 Jul 11:e14002. Epub 2020 Jul 11.

Department of Clinical Anatomy, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA.

Background and Objectives Dermatochalasis (DC) is part of the aging process of the eyelids, characterized by lax, redundant, overhanging excess eyelid skin. Mostly it is treated by surgical blepharoplasty. Lately alternative alternative non-surgical blepharoplasty technologies have been introduced. Read More

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http://dx.doi.org/10.1111/dth.14002DOI Listing

Indirect skin sign of COVID-19 days: striae rubrae.

J Cosmet Dermatol 2020 Jul 11. Epub 2020 Jul 11.

Department of Dermatology, Karabuk University, Faculty of Medicine, Karabuk, Turkey.

During COVID-19 pandemic, an increase was observed in stress-related dermatological diseases and COVID-19 related rash, while a significant decrease was observed in cosmetological outpatient applications. However, one month after the COVID-19 outbreak began, we observed a rapid increase especially individuals under 20 years of age diagnosed with stria rubrae in dermatology outpatient clinics. The number of patients diagnosed with striae rubrae was four times higher than last month (0. Read More

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http://dx.doi.org/10.1111/jocd.13607DOI Listing

Monitoring skin metastases during immuno- and targeted therapy using total-body 3D photography.

J Eur Acad Dermatol Venereol 2020 Jul 11. Epub 2020 Jul 11.

Department of Dermatology, University Hospital Erlangen, CCC-EMN, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Eruptive skin metastases in melanoma are an uncommon manifestation of rapidly progressive, systemic disease . Type and kinetics of these lesions have not been analyzed before, because of the rarity of the event and technical restrictions of total-body photography. We present the first sequential total-body 3D photography-based analysis by a VECTRA 360WB imaging system of a melanoma patient suffering from disseminated, spreading skin metastases under treatment with immune checkpoint antibodies and subsequent BRAF/MEK inhibition. Read More

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http://dx.doi.org/10.1111/jdv.16806DOI Listing

Disseminated Cryptococcosis with Cutaneous Manifestation.

Transpl Infect Dis 2020 Jul 11:e13412. Epub 2020 Jul 11.

Division of Infectious Diseases, Carolinas Medical Center, Atrium Health, Charlotte, NC, USA.

Cutaneous cryptococcosis is uncommon. It is usually a result of disseminated infection and can present with a wide of variety of skin lesions. We report a case of disseminated cryptococcosis in a kidney transplant recipient who presented with nodular lesions in the forehead following a bout of acute cellular rejection. Read More

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http://dx.doi.org/10.1111/tid.13412DOI Listing

The value of preoperative high-resolution MRI with microscopy coil for facial nonmelanoma skin cancers.

Skin Res Technol 2020 Jul 11. Epub 2020 Jul 11.

Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, P.R.China.

Background: The extent and depth of facial nonmelanoma skin cancers and the involvement of adjacent structures are critical features for surgical planning, but they are difficult to assess clinically. High-resolution MRI (HR-MRI) with microscopy coil may facilitate detailed evaluation of skin lesions. The authors performed this prospective study to determine the value of high-resolution microscopy coil MRI in the preoperative evaluation of nonmelanoma skin cancer. Read More

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http://dx.doi.org/10.1111/srt.12909DOI Listing

The link between Vitamin D and Covid-19: distinguishing facts from fiction.

Authors:
Peter Bergman

J Intern Med 2020 Jul 11. Epub 2020 Jul 11.

Department of Laboratory Medicine, Karolinska Institutet, Alfred Nobels Alle 8, 141 52, Huddinge, Sweden.

Vitamin D is produced in the skin under the influence of UVB-light from the sun or obtained via the diet by eating fatty fish, enriched dairy products or supplements. Vitamin D is known to support a healthy bone and severe deficiency may lead to osteomalacia or the rickets, which still occur in poor areas of the world. In addition, vitamin D support key functions in many organs, including the brain, muscle and the immune systems (Holick, 2007). Read More

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http://dx.doi.org/10.1111/joim.13158DOI Listing

Prospective randomized trial of endoscopic vs open radial artery harvest for CABG: Clinical outcome, patient satisfaction, and midterm RA graft patency.

J Card Surg 2020 Jul 11. Epub 2020 Jul 11.

Department of Cardiology, King Fahd Military Medical Complex, Dhahran, KSA.

Background And Aim: Endoscopic radial artery (RA) harvest (ERAH) is an alternative to open RA harvest (ORAH) technique. Our aim was to ascertain clinical outcomes, patent satisfaction, and 1-year angiographic patency rates after ERAH and ORAH.

Patients And Methods: A total of 50 patients undergoing coronary artery bypass grafting were prospectively randomized to two groups. Read More

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http://dx.doi.org/10.1111/jocs.14706DOI Listing

Frontal fibrosing alopecia: a descriptive cross-sectional study of 711 female cases from the U.K.

Br J Dermatol 2020 Jul 11. Epub 2020 Jul 11.

St. John's Institute of Dermatology, Guy's Hospital, London, SE1 9RT, U.K.

Frontal fibrosing alopecia (FFA) is an inflammatory primary scarring alopecia of uncertain aetiology that represents a variant of lichen planopilaris. It predominantly, although not exclusively, affects post-menopausal women. Its pathogenesis is characterised by immune-mediated follicular destruction at the level of the hair bulge, which leads to a clinical phenotype of progressive fronto-temporal hair and eyebrow loss that is often preceded by widespread body hair loss. Read More

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http://dx.doi.org/10.1111/bjd.19399DOI Listing

Long-Term Efficacy of Certolizumab Pegol for the Treatment of Plaque Psoriasis: Three-Year Results from Two Randomised Phase 3 Trials (CIMPASI-1 and CIMPASI-2).

Br J Dermatol 2020 Jul 11. Epub 2020 Jul 11.

Centre for Translational Research in Inflammatory Skin Diseases, Institute for Health Services Research in Dermatology and Nursing, University Medical Center Hamburg-Eppendorf and Skinflammation® Center, Hamburg, Germany.

Background: Certolizumab pegol (CZP) is an Fc-free, PEGylated anti-tumour necrosis factor biologic.

Objectives: Report three-year efficacy, pooled from CIMPASI-1 (NCT02326298) and CIMPASI-2 (NCT02326272) CZP in plaque psoriasis (PSO) phase 3 trials.

Methods: Adults with moderate to severe PSO for ≥6 months were randomised 2:2:1 to CZP 200 mg, CZP 400 mg, placebo, every two weeks (Q2W) for up to 48 weeks. Read More

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http://dx.doi.org/10.1111/bjd.19393DOI Listing

Secukinumab two weekly versus four weekly dosing in patients with plaque-type psoriasis: results from the randomized GAIN study.

Br J Dermatol 2020 Jul 11. Epub 2020 Jul 11.

Novartis Pharma GmbH, Nürnberg, Germany.

Background: Secukinumab is a fully human monoclonal antibody that selectively neutralizes IL-17A and shows long lasting efficacy and safety in plaque psoriasis. More evidence is required to optimize secukinumab dosing according to clinical response.

Objectives: GAIN compared the efficacy and safety of secukinumab 300 mg every two weeks (q2w) with 300mg every 4 weeks (q4w) in patients achieving PASI75 but not PASI90 after 16 weeks. Read More

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http://dx.doi.org/10.1111/bjd.19398DOI Listing

Spontaneously occurring melanoma in animals and their relevance to human melanoma.

J Pathol 2020 Jul 11. Epub 2020 Jul 11.

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.

In contrast to other cancer types, melanoma incidence has been increasing over the last 50 years, and while it still represents less than 5% of all cutaneous malignancies, melanoma accounts for the majority of skin cancer deaths, due to its propensity to metastasise. Whilst melanoma most commonly affects the skin, it can also arise in mucosal surfaces, the eye and the brain. For new therapies to be developed, a better understanding of the genetic landscape, signalling pathways and tumour-microenvironmental interactions are needed. Read More

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http://dx.doi.org/10.1002/path.5505DOI Listing

Guillain-Barre Syndrome Associated with SARS-CoV-2 Detection and a COVID-19 Infection in a Child.

J Pediatric Infect Dis Soc 2020 Jul 11. Epub 2020 Jul 11.

Faculty of Behavioral, Management and Social Sciences, Department Psychology, Health and Technology, University of Twente, Enschede, The Netherlands.

Coronavirus disease (COVID-19) is caused by SARS-CoV-2. Physicians in China reported what is believed to be the first adult case of a SARS-CoV-2 infection associated with acute Guillain-Barré syndrome (GBS), followed by five adult Italian patients and another case in the United States of America. In the current report we present one of the first descriptions of an association of GBS and SARS-CoV-2 infection within a child. Read More

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http://dx.doi.org/10.1093/jpids/piaa086DOI Listing

Insulin-like growth factor-I rescue of primary keratinocytes from pre- and post-ultraviolet B radiation effects.

J Photochem Photobiol B 2020 Jul 3;209:111951. Epub 2020 Jul 3.

Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.

Ultraviolet B radiation (UVBR) induces the formation of photolesions in epidermal keratinocytes, potentially affecting cellular function and contributing towards malignant transformation. Insulin-like growth factor-I (IGF-I) contributes to protection of keratinocytes against UVBR-induced damage. Studies have shown that exogenous IGF-I or dermal fibroblast conditioned media pre-UVBR contributes to protection in primary keratinocytes by preventing apoptosis, modulating cell cycle progression and affecting photolesion removal through its damage preventative effects, however, the efficacy of IGF-I post-UVBR has not been sufficiently addressed. Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2020.111951DOI Listing

Computer-aided classification of suspicious pigmented lesions using wide-field images.

Comput Methods Programs Biomed 2020 Jul 1;195:105631. Epub 2020 Jul 1.

Research Laboratory of Electronics, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA; MIT linQ, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139, USA; Brigham and Women's Hospital - Harvard Medical School, 75 Francis St, Boston, MA 02115, United States.

Background And Objective: Early identification of melanoma is conducted through whole-body visual examinations to detect suspicious pigmented lesions, a situation that fluctuates in accuracy depending on the experience and time of the examiner. Computer-aided diagnosis tools for skin lesions are typically trained using pre-selected single-lesion images, taken under controlled conditions, which limits their use in wide-field scenes. Here, we propose a computer-aided classifier system with such input conditions to aid in the rapid identification of suspicious pigmented lesions at the primary care level. Read More

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http://dx.doi.org/10.1016/j.cmpb.2020.105631DOI Listing

Pembrolizumab-induced severe oral mucositis in a patient with squamous cell carcinoma of the lung: A case study.

Lung Cancer 2020 Jun 30;147:21-25. Epub 2020 Jun 30.

Division of Medical Oncology-Hematology, Department of Internal Medicine, Kyung Hee University Hospital, College of Medicine, Kyung Hee University, Seoul, Republic of Korea. Electronic address:

Background: Immune checkpoint inhibitors, such as pembrolizumab, a humanized monoclonal antibody against programmed death-1, elicit antitumor activity in various types of cancers, including lung cancer. However, pembrolizumab has been reported to cause diverse immune-related adverse events associated with T-cell activation.

Case Presentation: We present the case of a 61-year-old man with advanced non-small cell lung cancer who was administered pembrolizumab as first-line treatment. Read More

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http://dx.doi.org/10.1016/j.lungcan.2020.06.033DOI Listing

A facile fabrication of dissolving microneedles containing 5-aminolevulinic acid.

Int J Pharm 2020 Jul 8:119554. Epub 2020 Jul 8.

CEA, LETI-DTBS, 17 rue des Martyrs, Grenoble Cedex, France.

Photodynamic therapy induced by protoporphyrin IX (PpIX) is widely used to treat precancerous skin lesions. The penetration depth of the prodrug 5-aminolevulinic acid (5-ALA) using topical application is currently limited, which hampers the production of PpIX in deep seated lesions. To enhance 5-ALA delivery in deep skin layers, a soluble microneedles patch (MN-patch) containing 5-ALA has been successfully developed by using a fast solvent casting molding method which could be easily up-scaled. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2020.119554DOI Listing

Design of pressure-sensitive adhesive suitable for the preparation of transdermal patches by hot-melt printing.

Int J Pharm 2020 Jul 8:119607. Epub 2020 Jul 8.

Department of Pharmaceutical Sciences, Università degli Studi di Milano - via G. Colombo 71 -, 20133 Milan, Italy. Electronic address:

This work aimed to design low-melting pressure sensitive adhesives and demonstrate the feasibility of the preparation of (trans)dermal patches by hot-melt ram extrusion printing. This approach allows defining both the geometry of (trans)dermal patch and the drug strength easily according to patient needs. The preparation steps are the mixing of a poly-ammonium methacrylate polymer (i. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2020.119607DOI Listing

Electrospun Vancomycin-loaded Nanofibers for Management of Methicillin-resistant Staphylococcus aureus-induced Skin Infections.

Int J Pharm 2020 Jul 8:119620. Epub 2020 Jul 8.

Assiut International Center of Nanomedicine, Al-Rajhy Liver Hospital, Assiut University, Assiut 71515, Egypt; Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt; Science Academy, Badr University in Cairo (BUC), Badr City, Cairo 11829 , Egypt. Electronic address:

Skin damage exposes the underlying layers to bacterial invasion, leading to skin and soft tissue infections. Several pathogens have developed resistance against conventional topical antimicrobial treatments and rendered them less effective. Recently, several nanomedical strategies have emerged as a potential approach to improve therapeutic outcomes of treating bacterial skin infections. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2020.119620DOI Listing

Structural and transcriptional evidence of mechanotransduction in the Drosophila suzukii ovipositor.

J Insect Physiol 2020 Jul 8:104088. Epub 2020 Jul 8.

Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige, Italy; Centre Agriculture, Food and Environment (C3A), University of Trento, San Michele all'Adige, Italy.

Drosophila suzukii is an invasive pest that prefers to lay eggs in ripening fruits, whereas most closely related Drosophila species exclusively use rotten fruit as oviposition site. This behaviour is allowed by an enlarged and serrated ovipositor that can pierce intact fruit skin, and by multiple contact sensory systems (mechanosensation and taste) that detect the optimal egg-laying substrates. Here, we tested the hypothesis that bristles present in the D. Read More

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http://dx.doi.org/10.1016/j.jinsphys.2020.104088DOI Listing

Solid Tumor Metastases to the Pancreas Diagnosed Using Fine-Needle Aspiration.

Am J Clin Pathol 2020 Jul 11. Epub 2020 Jul 11.

Department of Anatomical Pathology, Hepatology and Nutrition, University of Texas MD Anderson Cancer Center, Houston.

Objectives: Solid tumor metastases to the pancreas are rare, and only limited literature on the topic is available. In this retrospective study, we reviewed 107 cases of solid tumor metastases to the pancreas diagnosed by fine-needle aspiration (FNA) from 2005 to 2019.

Methods: Information including the patients' clinical histories, radiologic and pathologic findings, treatments, and follow-up were collected. Read More

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http://dx.doi.org/10.1093/ajcp/aqaa090DOI Listing

Molecular and cellular correlates of human nerve regeneration: ADCYAP1/PACAP enhance nerve outgrowth.

Brain 2020 Jul 11. Epub 2020 Jul 11.

Nuffield Department of Clinical Neurosciences, The University of Oxford, Oxford, UK.

We only have a rudimentary understanding of the molecular and cellular determinants of nerve regeneration and neuropathic pain in humans. This cohort study uses the most common entrapment neuropathy (carpal tunnel syndrome) as a human model system to prospectively evaluate the cellular and molecular correlates of neural regeneration and its relationship with clinical recovery. In 60 patients undergoing carpal tunnel surgery [36 female, mean age 62. Read More

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http://dx.doi.org/10.1093/brain/awaa163DOI Listing

Pollution assessment and health risk evaluation of eight (metalloid) heavy metals in farmland soil of 146 cities in China.

Environ Geochem Health 2020 Jul 10. Epub 2020 Jul 10.

Sate Key Laboratory of Pollution Control and Resource Reuse, School of Environment Science and Engineering, Tongji University, Shanghai, 200092, People's Republic of China.

Heavy metals are the most important indicator for farmland soil; however, in China, few provincial and national scales of studies have been done on heavy metals. Herein, by retrieving published studies, we calculated the spatial distribution characters and evaluated the health risks of Cu, Zn, Cd, Ni, Pb, Cr, As, and Hg in the farmland soil of 146 cities in China. Results showed that (1) the range (mean) values of eight (metalloid) heavy metals were as follows in mg/kg: Cu 0. Read More

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http://dx.doi.org/10.1007/s10653-020-00634-yDOI Listing

The Cancer Clear & Simple Story: Developing a Cancer Prevention Curriculum for Rural Wisconsin Through a Community Partnership.

J Cancer Educ 2020 Jul 10. Epub 2020 Jul 10.

Department of Medicine, Dell Medical School, The University of Texas at Austin, Room 7.702, 1701 Trinity St., Austin, TX, 78712-1850, USA.

To address rural cancer disparities, the University of Wisconsin Carbone Cancer Center launched a rural cancer project through its Cancer Health Disparities Initiative (CHDI) in 2010. With support from the National Cancer Institute's (NCI) National Outreach Network, CHDI conducted an assessment of rural counties and partnered with Adams County to implement a collaborative cancer education project. Together CHDI and Adams County partners selected an evidence-based educational curriculum, Understanding Cancer, as a basis for local adaptation for use with rural Wisconsin communities. Read More

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http://dx.doi.org/10.1007/s13187-020-01819-wDOI Listing

Anti-transcriptional intermediary factor 1-γ antibody-positive dermatomyositis induced by nivolumab for lung adenocarcinoma: A case report.

Invest New Drugs 2020 Jul 10. Epub 2020 Jul 10.

Department of Respiratory Medicine, Kobe City Medical Center General Hospital, 2-1-1, Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.

Immune checkpoint inhibitors can induce immune-related adverse events (irAEs) in different organs. Dermatomyositis is a rare form of systemic irAE. Although dermatomyositis-specific antibodies, especially anti-transcriptional intermediary factor 1-γ (anti-TIF1-γ) antibodies, have been detected in a few cases of immune checkpoint inhibitor-associated dermatomyositis, their titers before immunotherapy have not been examined. Read More

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http://dx.doi.org/10.1007/s10637-020-00974-7DOI Listing

Stoma complications and quality of life in patients with Indiana pouch versus appendico/neo-appendico-umbilicostomy urinary diversions.

World J Urol 2020 Jul 10. Epub 2020 Jul 10.

USC/Norris Comprehensive Cancer Center, USC Institute of Urology, 1441 Eastlake Avenue, Suite 7416, Los Angeles, CA, 90089, USA.

Objectives: To evaluate three subtypes of continent-cutaneous urinary diversion (CCUD); Indiana pouch (IP), right colon pouch with appendico-umbilicostomy (AU), and right colon pouch with neo-appendico-umbilicostomy (NAU), by investigating diversion-specific complications and quality-of-life outcomes.

Materials And Methods: A retrospective review of an IRB-approved database was conducted for perioperative and outcome data. The EORTC QLQ-C30 questionnaire was used to assess quality of life; all responses were obtained > 6 months after diversion. Read More

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http://dx.doi.org/10.1007/s00345-020-03348-zDOI Listing

Malpractice and Patient Safety Concerns.

Am J Clin Pathol 2020 Jul 11. Epub 2020 Jul 11.

Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles.

Objectives: "Assurance behaviors," a type of defensive medicine, involve physicians' utilization of additional patient services to avoid adverse legal outcomes. We aim to compare the use of clinical behaviors (such as ordering additional tests, services, and consultations) due to malpractice concerns with the same behaviors due to patient safety concerns.

Methods: A national sample of dermatopathologists (n = 160) completed an online survey. Read More

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http://dx.doi.org/10.1093/ajcp/aqaa088DOI Listing

Extrapulmonary manifestations of COVID-19.

Nat Med 2020 Jul 10. Epub 2020 Jul 10.

Division of Nephrology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.

Although COVID-19 is most well known for causing substantial respiratory pathology, it can also result in several extrapulmonary manifestations. These conditions include thrombotic complications, myocardial dysfunction and arrhythmia, acute coronary syndromes, acute kidney injury, gastrointestinal symptoms, hepatocellular injury, hyperglycemia and ketosis, neurologic illnesses, ocular symptoms, and dermatologic complications. Given that ACE2, the entry receptor for the causative coronavirus SARS-CoV-2, is expressed in multiple extrapulmonary tissues, direct viral tissue damage is a plausible mechanism of injury. Read More

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http://dx.doi.org/10.1038/s41591-020-0968-3DOI Listing

Comparative Morphology of the Lungs and Skin of two Anura, Pelophylax nigromaculatus and Bufo gargarizans.

Sci Rep 2020 Jul 10;10(1):11420. Epub 2020 Jul 10.

School of Medicine, Southeast University, Nanjing, 210009, China.

The lungs and skin are important respiratory organs in Anura, but the pulmonary structure of amphibians remains unclear due to the lack of a suitable procedure. This study improved the procedure used for fixing lungs tissues and used light microscopy, transmission electron microscopy and scanning electron microscopy to reveal the differences in the lung and skin morphologies between Pelophylax nigromaculatus (P. nigromaculatus) and Bufo gargarizans (B. Read More

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http://dx.doi.org/10.1038/s41598-020-65746-yDOI Listing

A second generation leishmanization vaccine with a markerless attenuated Leishmania major strain using CRISPR gene editing.

Nat Commun 2020 Jul 10;11(1):3461. Epub 2020 Jul 10.

Division of Emerging and Transfusion Transmitted Diseases, CBER, FDA, Silver Spring, MD, 20993, USA.

Leishmaniasis is a neglected tropical disease caused by Leishmania protozoa transmitted by infected sand flies. Vaccination through leishmanization with live Leishmania major has been used successfully but is no longer practiced because it resulted in occasional skin lesions. A second generation leishmanization is described here using a CRISPR genome edited L. Read More

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http://dx.doi.org/10.1038/s41467-020-17154-zDOI Listing

Chemosensory mechanisms of host seeking and infectivity in skin-penetrating nematodes.

Proc Natl Acad Sci U S A 2020 Jul 10. Epub 2020 Jul 10.

Molecular Biology Institute, University of California, Los Angeles, CA 90095;

Approximately 800 million people worldwide are infected with one or more species of skin-penetrating nematodes. These parasites persist in the environment as developmentally arrested third-stage infective larvae (iL3s) that navigate toward host-emitted cues, contact host skin, and penetrate the skin. iL3s then reinitiate development inside the host in response to sensory cues, a process called activation. Read More

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http://dx.doi.org/10.1073/pnas.1909710117DOI Listing

Multidimensional analysis of genetic background and environmental factors: Cases of atopy in asthmatic children.

Arch Pediatr 2020 Jul 7. Epub 2020 Jul 7.

Department of Cellular Biology, Faculty of Biological Sciences, Blida 1 University, Blida, Algeria.

The present work aimed, through a multidimensional analysis of a data set related to 76 asthmatic children (2-16 years), to their family, and to their antecedents, to establish typical profiles of children with asthma, combining similar or even identical characteristics. A questionnaire was presented to the parents concerning possible consanguinity, prematurity of the child, birth order, skin prick test results, presence of animals, indoor dampness, medical history, and cases of atopy among the children and their antecedents. The links between variables were first identified by means of chi-square tests. Read More

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http://dx.doi.org/10.1016/j.arcped.2020.05.011DOI Listing

Investigating proteome changes between primary and metastatic cutaneous squamous cell carcinoma using SWATH mass spectrometry.

J Dermatol Sci 2020 Jun 30. Epub 2020 Jun 30.

Centre for Translational Skin Research, Faculty of Medicine and Health, The University of Sydney, Westmead, New South Wales, Australia; Department of Dermatology, Westmead Hospital, Westmead, New South Wales, Australia. Electronic address:

Background: Cutaneous squamous cell carcinoma (cSCC) is a common malignancy worldwide and the first as the cause of death from keratinocytic carcinomas. Around 5% of primary cSCCs metastasize, leading to a 5-year survival rate of only 11 %.

Objective: This paper aims to investigate the proteome profile of primary and metastatic cSCC lesions for the identification of potential diagnostic biomarkers and molecular alterations. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2020.06.012DOI Listing

Case for diagnosis. Infiltrated areas on the trunk.

An Bras Dermatol 2020 Jun 25. Epub 2020 Jun 25.

Tropical Dermatology Clinic, Fundação de Dermatologia Tropical e Venereologia Alfredo da Matta, Manaus, AM, Brazil.

Leprosy is an infectious disease with chronic evolution, caused by Mycobacterium leprae, an acid-fast bacillus that mainly affects the skin and peripheral nervous tissue. Many of the clinical manifestations of leprosy can mimic connective tissue diseases. The authors present the case of a 49-year-old woman who had been treated for four years for systemic lupus erythematosus in a rheumatological service. Read More

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http://dx.doi.org/10.1016/j.abd.2019.12.007DOI Listing

Oncoplastic Repair in Breast Conservation: Comprehensive Evaluation of Techniques and Oncologic Outcomes of 937 Patients.

Clin Breast Cancer 2020 Jun 7. Epub 2020 Jun 7.

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.

Background: Breast-conserving surgery, especially with oncoplastic breast surgery (OBS), is becoming the standard of care in the surgical management of breast cancer. We investigated the applied technique of OBS and oncologic outcomes in a large series of patients.

Patients And Methods: This study was conducted between January 2008 and June 2018 in two centers in Iran. Read More

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http://dx.doi.org/10.1016/j.clbc.2020.05.016DOI Listing

Tattoo Pigment within Regional Lymph Nodes Mimicking Cutaneous Melanoma Metastasis.

Acta Dermatovenerol Croat 2020 Jul;28(1):47-48

Nikolina Jurišić, MD,

Dear Editor, The diagnosis of malignant melanoma accounts for 1-2% of all cancer diagnoses, around 4% of all malignant skin diseases, and 80% of all skin cancer deaths (1). The prognosis depends on several factors including tumor size, Clark level, Breslow thickness, location, ulceration, and presence of metastases. Detection of lymph node metastasis is initially accomplished by clinical examination and by operative evaluation for occult metastasis using sentinel lymph node biopsy (SLNB) when indicated (2). Read More

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Unusual Case of Granuloma Annulare Associated with Diabetes Mellitus.

Acta Dermatovenerol Croat 2020 Jul;28(1):45-46

Associate Professor Suzana Ljubojević Hadžavdić, MD, PhD, Department of Dermatology and Venereology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Šalata 4, 10000 Zagreb , Croatia;

Dear Editor, Granuloma annulare (GA) is an asymptomatic, chronic, and relatively common granulomatous skin condition which presents with annular papules usually slowly progressing into plaques on the extremities and the trunk. It usually presents with non-scaly, erythematous, annular plaques on the distal extremity (1,2). The pathogenesis of GA is still unknown, although a variety of possible factors contributing the disease have been reported, including drugs (3), insect bites, sun exposure, trauma, vaccinations, and viral infections (e. Read More

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Expression of p16 Protein in Cutaneous Basal Cell Carcinoma: Still far from Being Clearly Understood.

Authors:
Vladimir Bartoš

Acta Dermatovenerol Croat 2020 Jul;28(1):43-44

Vladimir Bartoš, MD, Faculty Hospital, Žilina, Slovakia;

Dear Editor, p16INK4a protein (p16) is an important tumor suppressor protein involved in the carcinogenesis of many human malignancies. I have read with interest an article by Donati et al. (1) in this journal, who investigated an expression of p16 and proliferation marker Ki-67 in cutaneous tumors. Read More

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Do Athletes Practicing Outdoors Know and Care Enough About the Importance of Photoprotection?

Acta Dermatovenerol Croat 2020 Jul;28(1):41-42

Prof. Marija Buljan, MD, PhD, Department of Dermatology and Venereology, Sestre milosrdnice University Hospital Centre, Vinogradska 29, 10000 Zagreb, Croatia;

Athletes practicing and competing outdoors are exposed to considerable UV radiation and at an increased risk for the development of UV-related skin conditions, including skin cancer. Risk factors for skin cancer include genetics, immune status, and particularly UV radiation. Independent factors, such as phototype, family or personal history of melanoma, number of nevi, atypical nevi and solar lentigines, as well as sunburn history are also important risk indicators for skin cancer, especially melanoma (1-3). Read More

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Incomplete Schnitzler Syndrome.

Acta Dermatovenerol Croat 2020 Jul;28(1):38-40

Mattias A.S. Henning, MD, Department of Dermatology, Zealand University Hospital, Sygehusvej 5, 4000 Roskilde, Denmark;

Schnitzler syndrome (SS) is a rare autoinflammatory disease that presents with chronic urticaria and monoclonal immunoglobulin (Ig) M or G, accompanied by fever, abnormal bone remodeling, skin biopsy with a neutrophilic dermal infiltrate, leukocytosis, or elevated C-reactive protein. It is usually refractory to antihistamines and immunosuppression. We present a case report of clinical SS without monoclonal Ig with robust response to interleukin-1 inhibitor anakinra. Read More

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Topical Imiquimod for Management of Recurrent Lentigo Maligna Melanoma in Situ.

Acta Dermatovenerol Croat 2020 Jul;28(1):34-37

Professor Igor Bartenjev, MD, PhD, Department of Dermatovenerology, Medical faculty, University of Ljubljana, Pod kostanji 4, 1000 Ljubljana, Slovenia;

Topical imiquimod is a medication approved for the treatment of external genital and perianal warts, actinic keratosis, and superficial basal cell carcinoma. There have also been reports of its successful use in patients with lentigo maligna melanoma in situ. An 80-year-old female patient was diagnosed with lentigo maligna melanoma in situ which was then surgically removed. Read More

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Understanding the Relationship Between Smoking and Hidradenitis Suppurativa.

Acta Dermatovenerol Croat 2020 Jul;28(1):9-13

Joško Miše, MD, Department of Dermatology and Venereology, University Hospital Center Zagreb, School of Medicine, University of Zagreb, Šalata 4 , 10000 Zagreb, Croatia;

Hidradenitis suppurativa (HS) is a chronic skin disease affecting hair follicles in intertriginous areas, characterized by deep, recurrent, painful nodules and abscesses, fistulae, sinus tracts, and scarring. With a prevalence of 1-4%, HS is not an uncommon disease. Several risk factors have been linked with the development of HS, such as genetic predisposition, smoking, and obesity, leading to the hypothesis that HS develops as a result of environmental triggers in a genetically susceptible individual. Read More

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miR-183-3p suppresses proliferation and migration of keratinocyte in psoriasis by inhibiting GAB1.

Hereditas 2020 Jul 10;157(1):28. Epub 2020 Jul 10.

Department of Dermatology, Affiliated Hospital of North Sichuan Medical College, No. 1, Maoyuan South Road, Nanchong City, 637000, Sichuan Province, China.

Background: MicroRNAs (miRNAs) target genes involved in the hyperproliferation of keratinocytes or immune dysfunction of psoriasis. This study prospectively determined the involvement of miR-183-3p in the pathogenesis of psoriasis.

Methods: Differentially expressed miR-183-3p between psoriatic lesional and non-lesional skin were determined by quantitative RT-PCR and in situ hybridization (ISH). Read More

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http://dx.doi.org/10.1186/s41065-020-00138-wDOI Listing

Profiling trial burden and patients' attitudes to improve clinical research in epidermolysis bullosa.

Orphanet J Rare Dis 2020 Jul 10;15(1):182. Epub 2020 Jul 10.

Department of Dermatology and Allergology, University Hospital of the Paracelsus Medical University Salzburg, Muellner Hauptstrasse 48, 5020, Salzburg, Austria.

Background: Epidermolysis bullosa (EB) comprises inherited mechanobullous dermatoses with considerable morbidity and mortality. While current treatments are symptomatic, a growing number of innovative therapeutic compounds are evaluated in clinical trials. Clinical research in rare diseases like EB, however, faces many challenges, including sample size requirements and recruitment failures. Read More

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http://dx.doi.org/10.1186/s13023-020-01443-3DOI Listing

Adipose Tissue: A Source of Stem Cells with Potential for Regenerative Therapies for Wound Healing.

J Clin Med 2020 Jul 8;9(7). Epub 2020 Jul 8.

Plastic Surgery and Burns Research Unit, University of Bradford, Bradford BD71DP, UK.

Interest in adipose tissue is fast becoming a focus of research after many years of being considered as a simple connective tissue. It is becoming increasingly apparent that adipose tissue contains a number of diverse cell types, including adipose-derived stem cells (ASCs) with the potential to differentiate into a number of cell lineages, and thus has significant potential for developing therapies for regenerative medicine. Currently, there is no gold standard treatment for scars and impaired wound healing continues to be a challenge faced by clinicians worldwide. Read More

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http://dx.doi.org/10.3390/jcm9072161DOI Listing

Antimicrobial Spectrum of Titroleane™: A New Potent Anti-Infective Agent.

Antibiotics (Basel) 2020 Jul 8;9(7). Epub 2020 Jul 8.

SETUBIO SA, Bioparc Vichy, F-03270 Hauterive, France.

Tea Tree oil (TTO) is well known for its numerous good properties but might be also irritating or toxic when used topically or ingested, thus limiting the number of possible applications in Humans. The aim of the study was to characterize the antimicrobial spectrum as well as the toxicity of Titroleane™, a new anti-infective agent obtained from TTO but cleared of its toxic monoterpenes part. The susceptibility to Titroleane™ of various pathogens (bacteria and fungi) encountered in animal and human health was studied in comparison with that of TTO. Read More

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http://dx.doi.org/10.3390/antibiotics9070391DOI Listing

The Effect of Muscle Exercise on Perforators Flow: A Prospective Cohort Study.

Medicina (Kaunas) 2020 Jul 8;56(7). Epub 2020 Jul 8.

Clinic of Plastic and Reconstructive Surgery, Department of Medicine (DAME), University of Udine, Piazzale Santa Maria della Misericordia 15, 33100 Udine, Italy.

: The metabolic response after exercise causes a significant increase in the muscle blood flow. While these effects are demonstrated for intra-muscular vessels, there is no evidence about the inter-muscular vessels, such as the septocutaneous perforators supplying the skin after they branch out from the deep source artery. The aim of our prospective study was to quantify the changes in the anterior tibial artery perforators arterial blood flow after mild isotonic exercise in a young and healthy population. Read More

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http://dx.doi.org/10.3390/medicina56070338DOI Listing

Secreted Factors from Keloid Keratinocytes Modulate Collagen Deposition by Fibroblasts from Normal and Fibrotic Tissue: A Pilot Study.

Biomedicines 2020 Jul 8;8(7). Epub 2020 Jul 8.

Burn Injury Research Unit, School of Biomedical Sciences, Faculty of Health and Medical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, Perth 6009, Australia.

Interactions between keratinocytes and fibroblasts in the skin layers are crucial in normal tissue development, wound healing, and scarring. This study has investigated the role of keloid keratinocytes in regulating collagen production by primary fibroblasts in vitro. Keloid cells were obtained from removed patients' tissue whereas normal skin cells were discarded tissue obtained from elective surgery procedures. Read More

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http://dx.doi.org/10.3390/biomedicines8070200DOI Listing

A Self-Powered Biosensor for Monitoring Maximal Lactate Steady State in Sport Training.

Biosensors (Basel) 2020 Jul 8;10(7). Epub 2020 Jul 8.

Physical Education Department, Northeastern University, Shenyang 110819, China.

A self-powered biosensor for monitoring the maximal lactate steady state (MLSS) during exercise has been developed for intelligently assisting training system. It has been presented to create poly (vinylidene fluoride) (PVDF)/Tetrapod-shaped ZnO (T-ZnO)/enzyme-modified nanocomposite film through an efficient and cost-effective fabrication process. This sensor can be readily attached to the skin surface of the tester. Read More

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http://dx.doi.org/10.3390/bios10070075DOI Listing

Study on the Effects of Grouting and Roughness on the Shear Behavior of Cohesive Soil-Concrete Interfaces.

Materials (Basel) 2020 Jul 8;13(14). Epub 2020 Jul 8.

Department of Geotechnical Engineering, Tongji University, Shanghai 200092, China.

Grouted soil-concrete interfaces exist in bored piles with post-grouting in pile tip or sides and they have a substantial influence on pile skin friction. To study the effect of grouting volume on the shearing characteristics of the interface between cohesive soil and concrete piles with different roughness, grouting equipment and a direct shear apparatus were combined to carry out a total of 48 groups of direct shear tests on cohesive soil-concrete interfaces incorporating the grouting process. The test results showed that the shear behavior of the grouted cohesive soil-concrete interface was improved mainly because increasing the grouting volume and roughness increased the interfacial apparent cohesion. Read More

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http://dx.doi.org/10.3390/ma13143043DOI Listing

Whole Genomic Analysis and Comparison of Two Canine Papillomavirus Type 9 Strains in Malignant and Benign Skin Lesions.

Viruses 2020 Jul 8;12(7). Epub 2020 Jul 8.

School of Veterinary Medicine, National Taiwan University, Taipei 10617, Taiwan.

Papillomaviruses (PVs) usually cause benign proliferative lesions in the stratified epithelium of various animal species. However, some high-risk types of PVs have been proven to lead to malignant transformations. In dogs, several canine papillomaviruses (CPVs) have been identified in malignant lesions and are suggested as one of the risk factors for the development of squamous cell carcinomas (SCCs). Read More

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http://dx.doi.org/10.3390/v12070736DOI Listing
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