765,199 results match your criteria Skin Malignancies Merkel Cell Carcinoma and Rare Appendageal Tumors* Plastic Surgery


A scalable database of organ doses for common diagnostic fluoroscopy examinations of children: procedures of current practice at the University of Florida.

Phys Med Biol 2019 Apr 23. Epub 2019 Apr 23.

Biomedical Engineering, University of Florida, PO Box 116131, 1275 Center Drive, Gainesville, Florida, 32611-6131, UNITED STATES.

Of all the medical imaging modalities that utilize ionizing radiation, fluoroscopy proves to be the most difficult to assess values of patient organ dose owing to the dynamic and patient-specific nature of the irradiation geometry and its associated x-ray beam characteristics. With the introduction of the radiation dose structured report (RDSR) in the mid-2000s, however, computational tools have been developed to extract patient and procedure-specific data for each irradiation event of the study, and when coupled to a computational phantom of the patient, values of skin and internal organ dose may be assessed. Unfortunately, many legacy and even current diagnostic fluoroscopy units do not have RDSR reporting capabilities, thus limiting these dosimetry reporting advances. Read More

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http://dx.doi.org/10.1088/1361-6560/ab1badDOI Listing
April 2019
1 Read

Myelopathy after zoster virus infection in immunocompetent patients: A case series.

J Spinal Cord Med 2019 Apr 23:1-5. Epub 2019 Apr 23.

a Department of Neurology , Habib Bourguiba University Hospital , Sfax , Tunisia.

Context: After primary infection, varicella zoster virus (VZV) becomes latent in ganglionic neurons. If immunity declines, VZV is reactivated and can spread to the dermatome depending from this ganglion and in some cases to the spinal cord. Myelopathy is rare and may develop in the absence of skin rash making the diagnosis very difficult. Read More

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http://dx.doi.org/10.1080/10790268.2019.1607053DOI Listing

Innate Immune Responses to in the Airway.

J Interferon Cytokine Res 2019 Apr 23. Epub 2019 Apr 23.

Department of Pathology and Laboratory Medicine, Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, New Jersey.

is an emerging opportunistic pathogen that has risen to become a serious global threat, prevalent in health care settings and the community, which results in high morbidity and mortality rates. Its alarming expansion of antibiotic resistance is one of the most problematic traits of and as so, this bacterium has been classified as a serious threat and high priority target by the CDC. The most common types of infections induced by this pathogen include pneumonia (both hospital and community acquired), bacteremia, skin and soft tissue, urinary tract infections, endocarditis, and meningitis. Read More

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http://dx.doi.org/10.1089/jir.2019.0008DOI Listing

Adverse immune reactions and non-immune medications for perioperative use.

Rev Alerg Mex 2019 Jan-Mar;66(1):99-114

Universidad Autónoma de Nuevo León, Hospital Universitario Dr. José Eleuterio González, Centro Regional de Alergia e Inmunología Clínica, Monterrey, Nuevo León, México.

Reactions to medications can occur through a mechanism mediated by immunoglobulin or otherwise, not both. Drug allergy is a type of adverse reaction to the drug and comprises a range of hypersensitivity reactions mediated by different immunological mechanisms with diverse clinical manifestations. A rate of 3. Read More

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http://dx.doi.org/10.29262/ram.v66i1.541DOI Listing

Chronic pruritus.

Rev Alerg Mex 2019 Jan-Mar;66(1):85-98

Universidad de Antioquia, Grupo de Alergología Clínica y Experimental, Medellín, Colombia.

Chronic pruritus is defined as an unpleasant sensation on the skin that causes scratching and lasts more than six weeks. This symptom may be a manifestation of a cutaneous or systemic disease and it jeopardizes the patients' quality of life, constantly altering their sleep and daily activities. The pathophysiology is complex and it includes multiple mediators and their respective receptors which, through different signaling pathways, carry information through type C nerve fibers towards the thalamus; from where it is distributed to various areas of the cerebral cortex. Read More

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http://dx.doi.org/10.29262/ram.v66i1.345DOI Listing

[Diagnosis of allergic sensitization in patients with allergic rhinitis and asthma in a tropical environment].

Rev Alerg Mex 2019 Jan-Mar;66(1):44-54

Clínica El Ávila, Servicio de Alergia e Inmunología Clínica, Caracas, Venezuela.

Background: Few studies in tropical developing countries have utilized molecular diagnosis to characterize allergen-specific responses to aeroallergens.

Objective: To investigate the in vivo and in vitro responses of IgE antibodies to inhalant allergens in allergic patients with rhinitis and/or asthma.

Methods: A prospective study in which patients with allergic rhinitis and/or asthma were included. Read More

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http://dx.doi.org/10.29262/ram.v66i1.570DOI Listing

[Sensitivity and specificity of the modified epicutaneous patch test in the diagnosis of respiratory allergy to Dermatophagoides pteronyssinus].

Rev Alerg Mex 2019 Jan-Mar;66(1):38-43

Universidad Autónoma de Puebla, Hospital Universitario de Puebla, Servicio de Alergia e Inmunología Clínica, Puebla, Puebla, México.

Background: The skin prick test is recognized as the gold standard for the specific diagnosis of allergy.

Objective: To determine the sensitivity and specificity of the epicutaneous patch test that has been modified for the diagnosis of respiratory allergy to Dermatophagoides pteronyssinus.

Methods: An observational, interpretative, prolective, and transversal study. Read More

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http://dx.doi.org/10.29262/ram.v66i1.533DOI Listing

[Results and limitations of epidemiological studies on food allergy. Focus on tropical countries].

Rev Alerg Mex 2019 Jan-Mar;66(1):9-17

Universidad de Antioquía, Grupo de Alergología Clínica y Experimental, Antioquía, Colombia.

Allergy and food atopy are a consequence of immune responses unadapted to antigens mediated by common and otherwise harmless foods. Food allergy (AF) occurs frequently in children under three years of 3 to 15%, as well as in people over 6 to 8%. AF may be mediated by immunoglobulin E or cellular mechanisms and may present with a wide variety of symptoms in the skin, respiratory and gastrointestinal tracts. Read More

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http://dx.doi.org/10.29262/ram.v66i1.340DOI Listing

[Allergy to food in adults with allergic respiratory diseases: prevalence and clinical manifestations].

Rev Alerg Mex 2019 Jan-Mar;66(1):1-8

Hospital Civil de Guadalajara Dr. Juan I. Menchaca, Servicio de Alergia e Inmunología Clínica, Guadalajara, México.

Background: Food allergy is considered a typical problem in the pediatric population, however, cases occur in adults more frequently.

Objective: To determine the prevalence of food allergy in patients with allergic rhinitis and asthma; as well as the foods and symptoms most related to said problem.

Methods: Through a cross-sectional study, the information of 257 adults with asthma or allergic rhinitis was analyzed. Read More

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http://dx.doi.org/10.29262/ram.v66i1.400DOI Listing

Economic evaluations of onchocerciasis interventions: a systematic review and research needs.

Trop Med Int Health 2019 Apr 23. Epub 2019 Apr 23.

London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, UK.

Objective: To provide a systematic review of economic evaluations that have been conducted for onchocerciasis interventions, to summarise current key knowledge and to identify research gaps.

Method: A systematic review of the literature was conducted on the 8 of August 2018 using the PubMed (MEDLINE) and ISI Web of Science electronic databases. No date or language stipulations were applied to the searches. Read More

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http://dx.doi.org/10.1111/tmi.13241DOI Listing

Facilitating closeness between babies with congenital abnormalities and their parents in the NICU: A qualitative study of neonatal nurses' experiences.

J Clin Nurs 2019 Apr 23. Epub 2019 Apr 23.

School of Nursing and Midwifery, Western Sydney University, Australia.

Aims And Objectives: This qualitative study explored the experiences of neonatal nurses with facilitating closeness between parents and babies with congenital abnormalities in the Neonatal Intensive Care Unit (NICU).

Background: Babies with congenital abnormalities often require admission to the Neonatal Intensive Care Unit. Parents may experience emotional distancing from their baby, due to their response to their baby's congenital abnormality, as well as physical separation due to their baby's hospitalisation in the NICU. Read More

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http://dx.doi.org/10.1111/jocn.14894DOI Listing

Rare cancers in childhood and adolescence in Brazil: First report of data from 19 population-based cancer registries.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

IRCCS Foundation, Evaluative Epidemiology Unit, Evaluative Epidemiology Unit, National Cancer Institute, Milan, Italy.

Background: Rare childhood cancer is challenging to define. The Italian Pediatric Rare Tumor (TREP) Study considers rare tumors to include solid malignancies characterized by an annual incidence rate of <2 cases per 1 million and not enrolled in clinical trials. The objective of the current study was to analyze the population incidence rate of rare tumors among children and adolescents (those aged birth-19 years) in Brazil. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32121
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http://dx.doi.org/10.1002/cncr.32121DOI Listing
April 2019
1 Read

Microencapsulated Parathyroid Allotransplantation in the Omental Tissue.

Artif Organs 2019 Apr 23. Epub 2019 Apr 23.

Bezmialem Vakif University, Faculty of Medicine, Department of General Surgery, Istanbul, Turkey.

Background: Permanent hypoparathyroidism is a severe clinical condition accompanied by low parathormone level. Conventional treatment requires life-long medication, and daily drug usage has some side-effects. To avoid this circumstance, transplantation is an alternative and curative option. Read More

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http://dx.doi.org/10.1111/aor.13475DOI Listing

Poly(lactide- co-glycolide) Nanoparticles for Prolonged Therapeutic Efficacy of Esculentin-1a-Derived Antimicrobial Peptides against Pseudomonas aeruginosa Lung Infection: in Vitro and in Vivo Studies.

Biomacromolecules 2019 Apr 23. Epub 2019 Apr 23.

Laboratory affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, Department of Biochemical Sciences "A. Rossi Fanelli" , Sapienza University of Rome , via degli Apuli, 9 , 00185 Rome , Italy.

Due to their excellent in vitro activity against multidrug resistant bacteria, antimicrobial peptides (AMPs) hold promise for treatment of Pseudomonas aeruginosa lung infections in cystic fibrosis (CF) sufferers. In this work, poly(lactide- co-glycolide) (PLGA) nanoparticles for lung delivery of AMPs deriving from the frog-skin esculentin-1a, namely, Esc(1-21) and Esc(1-21)-1c (Esc peptides), were successfully developed. Improved peptide transport through artificial CF mucus and simulated bacterial extracellular matrix was achieved in vitro. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01829DOI Listing

Grover’s Disease Treated With Total Skin Electron Beam Radiotherapy

J Drugs Dermatol 2019 Apr;18(4):392-393

Persistent Grover's disease can cause significant symptoms of pruritus thereby decreasing quality of life. Many patients undergo successful conservative management of their disease; however, a subset of patients is recalcitrant despite multiple lines of therapy. Accordingly, we present, to our knowledge, the first reported case of recalcitrant Grover's disease treated successfully with radiotherapy. Read More

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Treatment of Psoriasis With Biologics and Apremilast in Patients With a History of Malignancy: A Retrospective Chart Review

J Drugs Dermatol 2019 Apr;18(4)

Introduction: Biologics have transformed the management of moderate-to-severe psoriasis. The risk of developing a malignancy during treatment is an important consideration, and many studies have been conducted to determine the magnitude of this risk. However, there is little research on the use of biologic treatment in psoriasis patients with a history of established malignancy. Read More

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A comparative study on the effectiveness of herbal extracts vs 2.5% benzoyl peroxide in the treatment of mild to moderate acne vulgaris.

J Cosmet Dermatol 2019 Apr 23. Epub 2019 Apr 23.

Skin Center, Srinakharinwirot University, Bangkok, Thailand.

Background: Although there is a standard guideline for the treatment of acne, it is still a common skin disease, and suboptimal medication adherence is a major reason for treatment failure. Herbal extracts are an interesting alternative medicine because they consist of a variety of active ingredients. Moreover, herbal extracts may have improved therapeutic efficacy because of the combination of various herbs. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.12962
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http://dx.doi.org/10.1111/jocd.12962DOI Listing
April 2019
1 Read

Therapeutic patient education and self-management support for patients with psoriasis - a systematic review.

J Dtsch Dermatol Ges 2019 Apr 23. Epub 2019 Apr 23.

Division of Evidence-Based Medicine, Department of Dermatology, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Psoriasis is a chronic inflammatory skin condition. Patient education may be one option to improve adherence and coping. The aim of this systematic review is to identify studies evaluating educational interventions for psoriasis patients. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ddg.13840
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http://dx.doi.org/10.1111/ddg.13840DOI Listing
April 2019
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The psychological and aesthetic impact of age-related hair changes in females.

J Cosmet Dermatol 2019 Apr 23. Epub 2019 Apr 23.

Department of Dermatology, San Diego School of Medicine, University of California, La Jolla, California.

Background: While dermatologists focus on practices to promote anti-aging, thinning hair that frames a more rejuvenated face can affect age perception and cosmesis.

Objectives: To characterize the effects of age-related hair changes on age determination and perceived attractiveness.

Methods: A search was conducted for articles on intrinsic and extrinsic aging as it relates to hair. Read More

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http://dx.doi.org/10.1111/jocd.12960DOI Listing

Development and evaluation of novel topical gel of neem extract for the treatment of bacterial infections.

J Cosmet Dermatol 2019 Apr 23. Epub 2019 Apr 23.

Department of Pharmaceutics, N.G.S.M. Institute of Pharmaceutical Sciences, NITTE Deemed to be University, Mangalore, India.

Background: The microspheres are one of the major formulations in the novel drug delivery systems. These days' scientists are predominantly focusing on natural plant products because of the poisonous effect of synthetic drug molecules. From olden days itself, neem has some excellent antibacterial activities. Read More

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http://dx.doi.org/10.1111/jocd.12965DOI Listing

How can Dermanyssus gallinae (De Geer 1778) (Acari: Anactinotrichida: Dermanyssidae) walk upwards on slippery surfaces?

Avian Pathol 2019 Apr 23:1-25. Epub 2019 Apr 23.

b Wageningen Livestock Research , P.O. Box 338, 6700 AH Wageningen , The Netherlands.

Scanning electron microscopy observations of the distal leg region of the poultry red mite Dermanyssus gallinae (De Geer 1778) identified the presence of a compound ambulacrum, the part of the leg that contacts the substratum when the mite walks. The ambulacrum is comprised of a praetarsus (the ambulacrum stalk), a pulvillus and two claws. The pulvillus is a weakly sclerotized structure that can be partly expanded or retracted in the praetarsus. Read More

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http://dx.doi.org/10.1080/03079457.2019.1608909DOI Listing

Natural resolution of non-anaphylactic shrimp allergy in patients diagnosed 10 years earlier by oral food challenge.

Asian Pac J Allergy Immunol 2019 Apr 23. Epub 2019 Apr 23.

Division of Allergy and Clinical Immunology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Shrimp allergy is considered a lifelong condition. The natural resolution of shrimp allergy is not well studied.

Objective: To investigate the natural resolution of shrimp allergy among a cohort of patients diagnosed with shrimp allergy 10 years earlier by oral shrimp challenge. Read More

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http://dx.doi.org/10.12932/AP-080119-0470DOI Listing

The clinical significance of antinuclear antibodies and specific autoantibodies in juvenile and adult systemic lupus erythematosus patients.

Asian Pac J Allergy Immunol 2019 Apr 23. Epub 2019 Apr 23.

Center of Excellence in Immunology and Immune-mediated Diseases, Department of Microbiology.

Background: Juvenile systemic lupus erythematosus (JSLE) and adult SLE (ASLE) patients present with different clinical manifestations, but it is unknown if there are differences in their antinuclear autoantibody (ANA) profiles or if staining patterns are associated with specific autoantibodies and clinical manifestations.

Objective: To determine whether distinct types and numbers of ANA-staining patterns are associated with specific autoantibodies and clinical manifestations in JSLE and ASLE patients.

Methods: A retrospective study was performed in Thai children (n = 146) and adults (n = 180) diagnosed with SLE using the Systemic Lupus International Collaborating Clinics classification criteria. Read More

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http://dx.doi.org/10.12932/AP-211218-0465DOI Listing

Association of HLA genotypes with Beta-lactam antibiotic hypersensitivity in children.

Asian Pac J Allergy Immunol 2019 Apr 23. Epub 2019 Apr 23.

Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand 10400.

Background: Beta-lactam (BL) antibiotics hypersensitivity is common in children. Clinical manifestation of BL hypersensitivity varies from mild to severe cutaneous adverse drug reactions (SCARs).

Objective: To determine the association of HLA genotype and BL hypersensitivity and the prevalence of true drug allergy in patients with history of BL hypersensitivity. Read More

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http://dx.doi.org/10.12932/AP-271118-0449DOI Listing

Red Deer Umbilical Cord Lining Mesenchymal Stem Cell Extract Cream for Rejuvenation of the Face

J Drugs Dermatol 2019 Apr;18(4):363-366

Background: Aging is a multifactorial process that involves all components of the skin. Both intrinsic and extrinsic forces play a role in this aging process. A new patented protein mix derived from red deer umbilical cord lining stem cell conditioned media (Calecim® Multi Action Cream, CellResearch Corporation, Singapore) has been developed to improve the signs of aging. Read More

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The Effect of Calcipotriene-Betamethasone Dipropionate Aerosol Foam versus Vehicle on Target Lesions in Moderate Severity Plaque Psoriasis: Focus on Elbows and Knees

J Drugs Dermatol 2019 Apr;18(4):358-361

Calcipotriene 0.005%, a vitamin D analog, plus betamethasone dipropionate 0.064%, a high potency topical corticosteroid, are combined in an aerosol foam formulation proven to be effective and safe using once daily topical application for plaque psoriasis. Read More

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A Randomized Controlled Tolerability Study to Evaluate Reformulated Benzoyl Peroxide Face Washes for Acne Vulgaris

J Drugs Dermatol 2019 Apr;18(4):350-356

Introduction: This randomized, evaluator-blind, single-center, parallel-group study sought to evaluate the tolerability of two reformulated face washes containing benzoyl peroxide (BPO) in adults with mild to moderate acne vulgaris. Methods: Healthy adults with mild to moderate acne vulgaris were randomly allocated (1:1:1) to one of two reformulated test products (containing BPO at a concentration of either 4% or 10%) or an older formulation containing 10% BPO (reference product), which they applied twice daily for 21±2 days. The primary tolerability assessment was clinical assessment of signs and symptoms of cutaneous irritation by a dermatologist. Read More

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A Double-Blind Randomized Controlled Trial Evaluating the Efficacy and Tolerability of a Topical Body Treatment in Combination With Cryolipolysis Procedures

J Drugs Dermatol 2019 Apr;18(4):342-348

Background: Non-surgical fat reduction through cold application, cryolipolysis, is an extremely popular procedure. Apoptosis of the fat cell content may take around 3 months to resolve. Objective: A topical test product was compared to a bland emollient as an adjunct to the cryolipolysis procedure of the upper arms to determine if the product could hasten outcomes in these patients. Read More

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Liver fluke (Fasciola hepatica) co-infection with bovine tuberculosis (bTB) in cattle: a prospective herd-level assessment of herd bTB risk in dairy enterprises.

Transbound Emerg Dis 2019 Apr 23. Epub 2019 Apr 23.

Agri-food and Biosciences Institute, Veterinary Science Division, Stormont, Belfast, UK.

Co-infection of tuberculosis (TB) and helminths is recognised as a significant problem in regions where such pathogens are endemic and chronic cases exist. Co-infection can modulate the immune system leading to interference with diagnostic tests, increased pathological impacts, and pathogen persistence. However, research has found that such interactions between pathogens can be context and species specific. Read More

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http://dx.doi.org/10.1111/tbed.13209DOI Listing

Potential vector species of carp edema virus (CEV).

J Fish Dis 2019 Apr 23. Epub 2019 Apr 23.

Department of Fish Diseases, National Veterinary Research Institute, Pulawy, Poland.

During a PCR-based CEV survey in Poland in 2015-2017, the virus was detected in many farms both in clinical and asymptomatic cases and in common as well as in koi carp (Cyprinus carpio). In order to evaluate the potential carrier role of fish species that share the same habitats with carp, an experimental trial was performed. Investigations carried out on specimens of bleak (Alburnus alburnus), crucian carp (Carassius carassius), European perch (Perca fluviatilis), Prussian carp (Carassius gibelio), roach (Rutilus rutilus) and tench (Tinca tinca) cohabited with CEV-infected carp yielded positive results. Read More

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http://dx.doi.org/10.1111/jfd.13000DOI Listing

Which Nanobasics Should Be Taught in Medical Schools?

AMA J Ethics 2019 Apr 1;21(4):E337-346. Epub 2019 Apr 1.

The Walter J. Hamlin Professor of Dermatology and chair of the Department of Dermatology at Northwestern University Feinberg School of Medicine in Chicago, Illinois, where she also serves as the director of the Skin Disease Research Center.

The progressive growth in nanotechnology approaches to diagnostics and therapeutics, especially for cancer, necessitates training physicians in nanoethics. This article explains why it is critical for medical education to include instruction in nanotechnology, nanomedicine, nanotoxicology, and nanoethics and suggests basic concepts educators can use to infuse curricula with this content. Read More

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http://dx.doi.org/10.1001/amajethics.2019.337DOI Listing

Behaviour of cell penetrating peptide TAT-modified liposomes loaded with salvianolic acid B on the migration, proliferation, and survival of human skin fibroblasts.

J Liposome Res 2019 Apr 23:1-14. Epub 2019 Apr 23.

a Department of Traditional Chinese Medicine , Guangdong Pharmaceutical University of China , Guangzhou , PR China.

To investigate the efficacy of cell penetrating peptide TAT-modified liposomes loaded with salvianolic acid B (SAB-TAT-LIP) on the proliferation, migration, survival, and TGF-β expression of human skin fibroblasts (HSF) and to preliminarily evaluate its effect on the prevention and treatment of hypertrophic scars. SAB-TAT-LIP was prepared using the pH gradient reverse-phase evaporation method. The properties of the liposomes including morphology, percent entrapment efficiency, mean diameter, polydispersity index (PDI), zeta potential, in vitro release, in vitro percutaneous absorption, and serum stability were studied. Read More

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https://www.tandfonline.com/doi/full/10.1080/08982104.2019.1
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http://dx.doi.org/10.1080/08982104.2019.1593451DOI Listing
April 2019
1 Read

Tactile sensitivity, tactile acuity, and affective touch: from childhood to early adolescence.

Somatosens Mot Res 2019 Apr 23:1-7. Epub 2019 Apr 23.

b Department of Psychology , Sapienza University of Rome , Rome , Italy.

The development of somatosensation and affective touch acquires a central role throughout our lives, for several reasons. In adults, these functions are driven by different, neuroanatomically and functionally segregated fibres. To date, very little is known about the basic features of these fibres in childhood and this lack of knowledge is mirrored in the affective touch domain, where there are no studies on the main physiological features of the tactile processes linked to the stimulation of the hairy skin, namely the preferential site of affective touch. Read More

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http://dx.doi.org/10.1080/08990220.2019.1604334DOI Listing

Development of a read-across workflow for skin irritation and corrosion predictions.

SAR QSAR Environ Res 2019 Apr;30(4):279-298

a Chemicals Safety Department , Responsible Care & Quality Assurance Division , Mitsui Chemicals, Inc ., Chiba , Japan.

We developed a read-across workflow using the OECD QSAR Toolbox for the prediction of skin irritation and corrosion. In the workflow, we gathered analogues using an improved profiler for skin irritation and corrosion to define valid categories. In addition, we refined categories by removing chemicals based on melting points and structural features. Read More

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http://dx.doi.org/10.1080/1062936X.2019.1595136DOI Listing

The Association between Genetic Variation in Wnt Transcription Factor TCF7L2 (TCF4) and Alopecia Areata.

Immunol Invest 2019 Apr 23:1-8. Epub 2019 Apr 23.

a Skin Research Center , Shahid Beheshti University of Medical Sciences , Tehran , Iran.

Background: Alopecia areata (AA) is a non-scarring hair loss with a polymorphous presentation ranging from patchy lesions to involvement of the entire scalp. The disease is the consequence of an autoimmune attack on hair bulbs that results in a premature transition of hair follicles to catagen and telogen. Thus the Wnt/β-catenin signaling pathway that regulates the hair cycling might be involved in the pathogenesis of AA. Read More

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http://dx.doi.org/10.1080/08820139.2019.1597109DOI Listing
April 2019
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Netrin-1 plays a critical role in regulating capacities of epidermal stem cells upon ultraviolet-B (UV-B) irradiation.

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):1416-1422

a Department of Burns and Plastic Surgery , Shandong Provincial Hospital Affiliated to Shandong University , Jinan , China.

Loss of the capacities of epidermal stem cells (ESCs) induced by ultraviolet-B (UV-B) irradiation has been widely associated with various skin diseases. Netrin-1, a member of the axonal guidance protein family, has displayed diverse biological functions in different types of cells and tissues, mediated by its specific receptor UNC-5 homolog B (UNC5b). In this study, we examined the physiological functions of netrin-1 and UNC5b in ESCs upon UV-B exposure. Read More

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http://dx.doi.org/10.1080/21691401.2019.1593849DOI Listing
December 2019

Optoacoustic Mesoscopy Analysis and Quantitative Estimation of Specific Imaging Metrics in Fitzpatrick skin phototypes II to V.

J Biophotonics 2019 Apr 23:e201800442. Epub 2019 Apr 23.

Laboratory of Bio-Optical Imaging, Singapore Bioimaging Consortium, Agency for Science Technology and Research (A*STAR), Singapore.

Raster Scanning Optoacoustic Mesoscopy (RSOM) is a novel optoacoustic imaging modality that offers non-invasive, label-free, high resolution (~7 μm axial, ~30 μm lateral) imaging up to 1-2 mm below the skin, providing novel quantitative insights into skin pathophysiology. As the RSOM image contrast mechanism is based on light absorption, it is expected that the amount of melanin present in the skin will affect RSOM images. However, the effect of skin tone in the performance of RSOM has not been addressed so far. Read More

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http://dx.doi.org/10.1002/jbio.201800442DOI Listing

Effective remission of Chidamide on treatment of advanced mycosis fungoides:An unusual case report.

Dermatol Ther 2019 Apr 22:e12944. Epub 2019 Apr 22.

Dalian Medical University.

Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common types of primary cutaneous T-cell lymphoma (CTCL), which primarily involves skin without curative treatment. We report a case of a 29-year-old female Chinese patient, who developed multiple cutaneous lesions gradually for 5 years. However, the patient could not tolerate pruritus and ulceration of cutaneous lesions, so she was admitted to hospital and diagnosed with advanced MF based on clinical manifestation, laboratory and image results. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/dth.12944
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http://dx.doi.org/10.1111/dth.12944DOI Listing
April 2019
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Activation of Mast Cells Mediates Inflammatory Response in Psoriasis: Potential New Therapeutic Approach with IL-37.

Dermatol Ther 2019 Apr 22:e12943. Epub 2019 Apr 22.

Department of Microbiology and Infectious Diseases, Aristotle University of Thessaloniki, Macedonia, Greece.

Psoriasis (PS) is an autoimmune disorder characterized by chronic inflammatory skin immune-mediated disease which occurs in 2-4% of the worldwide population. PS is associated with an increased risk of cardiovascular disease and depression, and 30% of PS patients are affected with psoriatic arthritis. PS presents excessive keratinocyte proliferation, abnormal differentiation, and elevated mast cell (MC) number. Read More

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http://dx.doi.org/10.1111/dth.12943DOI Listing

Autonomic responses to fear conditioning among women with PTSD and dissociation.

Depress Anxiety 2019 Apr 22. Epub 2019 Apr 22.

Department of Psychiatry, Harvard Medical School, Cambridge, Massachusetts.

Background: Individuals with posttraumatic stress disorder (PTSD) demonstrate alterations in autonomic responses to fear conditioning, such as exaggerated startle and poor fear inhibition. However, there is a paucity of research on fear conditioning among individuals with PTSD and dissociative symptoms, which represents 10-30% of those with PTSD. The current study used a fear-potentiated startle (FPS) conditioning paradigm to examine autonomic responses among women with PTSD and a range of dissociative symptoms. Read More

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http://dx.doi.org/10.1002/da.22903DOI Listing

Linear Cutaneous Hypopigmentation and Atrophy Associated With Intralesional Steroid Injection: A Rarely Described Adverse reaction.

Dermatol Ther 2019 Apr 22:e12941. Epub 2019 Apr 22.

Dermatology Department, Sapienza University of Rome, Rome, Italy.

Intralesional steroid injection is a common and highly effective treatment procedure, which can be successfully used for several dermatologic, rheumatologic and orthopedic disorders. However, it may be associated with various local side effects, such as pain, granulomatous reaction, allergic reactions, hypo- or hyperpigmentation and, uncommonly, skin atrophy. A peculiar and rare side effect of steroid injection is linear hypopigmentation and atrophy, which is probably an expression of lymphatic spread of corticosteroid crystals. Read More

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http://dx.doi.org/10.1111/dth.12941DOI Listing

POEMS Syndrome: update on diagnosis, risk-stratification, and management.

Am J Hematol 2019 Apr 22. Epub 2019 Apr 22.

Professor of Medicine and Laboratory Medicine, Mayo Clnic.

Disease Overview: POEMS syndrome is a paraneoplastic syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyradiculoneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease. Minor features include organomegaly, endocrinopathy, characteristic skin changes, papilledema, extravascular volume overload, and thrombocytosis. Read More

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http://dx.doi.org/10.1002/ajh.25495DOI Listing

Evaluation of tuberculin skin test (TST) in vervet monkeys (Chlorocebus pygerythrus) using experimentally tuberculin sensitized animals.

J Med Primatol 2019 Apr 22. Epub 2019 Apr 22.

Department of Pathology and Epidemiology, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran.

Background: Nowadays, several test methods with different useful values are available for diagnosis of the tuberculosis (TB) in non-human primates (NHPs). Despite some limitations of tuberculin skin test (TST), it is still the most commonly used method for TB testing of NHPs.

Methods: During this investigation, TST was performed upon three groups of experimentally tuberculin sensitized and one group of non-sensitized vervet monkeys (Chlorocebus pygerythrus) by means of two types of old tuberculin (OT) and two types of purified protein derivative (PPD) tuberculin. Read More

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http://dx.doi.org/10.1111/jmp.12413DOI Listing

Photodynamic therapy: A targeted literature review focussing on outcomes and optimisation in solid organ transplant recipients.

Australas J Dermatol 2019 Apr 22. Epub 2019 Apr 22.

Flinders Medical Centre, Bedford Park, South Australia, Australia.

Squamous cell carcinoma incidence is 65- to 250-fold in solid organ transplant recipients, BCC is 10-fold and in Australia, rates of skin cancer in solid organ transplant recipients reach 70-82% prevalence within the first 20 years; hence, effective, evidence-based treatment of early and precancerous lesions is an essential tool in dermatological patient care. Photodynamic therapy is used to treat a range of conditions including actinic keratoses, squamous cell carcinoma in situ, superficial basal cell carcinoma and nodular basal cell carcinoma. A literature review was undertaken to examine the outcomes of photodynamic therapy in solid organ transplant recipients and methods of optimising outcomes in solid organ transplant recipients. Read More

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http://dx.doi.org/10.1111/ajd.13049DOI Listing

A case of widespread molluscum contagiosum caused by baricitinib, a Janus kinase inhibitor.

Australas J Dermatol 2019 Apr 22. Epub 2019 Apr 22.

Skin and Cancer Foundation Inc, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/ajd.13059DOI Listing

Keratinocyte cancer excisions in Australia: Who performs them and associated costs.

Australas J Dermatol 2019 Apr 22. Epub 2019 Apr 22.

Department of Population Health, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.

Background/objective: To describe the clinical settings in which keratinocyte cancers are excised in Queensland and describe the types of practitioners who excise them; to examine costs; and to identify predictors of hospital admission.

Methods: We used linked data for participants from the QSkin study (n = 43 794), including Medicare claims and Queensland hospital admissions relating to treatment episodes for incident keratinocyte cancers from July 2011 to June 2015. We used multinomial logistic regression to measure associations between demographic and clinical characteristics and treatment setting. Read More

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http://dx.doi.org/10.1111/ajd.13056DOI Listing

Recurrent radiation recall dermatitis triggered by radiological procedures in a patient with breast cancer.

Australas J Dermatol 2019 Apr 22. Epub 2019 Apr 22.

Department of Pathology, Medichal School, Yıldırım Beyazit University, Ankara, Turkey.

Radiation recall dermatitis is an acute inflammatory reaction that occurs on previously irradiated skin by usage of chemotherapeutic agents and other triggering drugs. The recall reaction is usually associated with drugs but may also occur following ultraviolet radiation. We report a patient with radiation recall dermatitis, triggered after imaging procedures that involved radiation. Read More

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http://dx.doi.org/10.1111/ajd.13037DOI Listing
April 2019
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Generalised eruptive histiocytosis: Case report.

Australas J Dermatol 2019 Apr 22. Epub 2019 Apr 22.

Department of Dermatology and Venereology, Hospital Garcia de Orta, Almada, Portugal.

Generalised eruptive histiocytosis is a self-limited and benign non-Langerhans cell histiocytic disorder, characterised by recurrent crops of symmetrically distributed skin to red to brown coloured papules on the trunk and proximal extremities. Clinical and pathological correlation is required to establish the diagnosis. We herein present the clinical and histological features of generalised eruptive histiocytosis in a 24-year-old female patient. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ajd.13062
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http://dx.doi.org/10.1111/ajd.13062DOI Listing
April 2019
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