Search Our Scientific Publications & Authors

J Reconstr Microsurg 2019 Feb 22. Epub 2019 Feb 22.

Department of Human Pathology of the Adult, the Child and the Adolescent, University of Messina, Messina, Italy.

Background:  Preclinical training in perforator flap harvesting is typically conducted on living animal models; however, repeated training is not possible with these models because of ethical and/or economical constraints. We describe an anterolateral thigh flap (ALT flap) training model using chicken thigh that seems to be an appropriate training model prior, for example, to raise a perforator flap in a living rat or swine model.

Methods:  A total of 10 chicken legs were used in this study. Read More

Biomed Mater 2019 Feb 22. Epub 2019 Feb 22.

Product Development Group Zurich, Eidgenossische Technische Hochschule Zurich Departement Maschinenbau und Verfahrenstechnik, Zurich, ZH, SWITZERLAND.

Human autologous bioengineered skin has been successfully developed and used to treat skin injuries in a growing number of cases. In current clinical studies, the biomaterial used is fabricated via plastic compression of collagen hydrogel to increase the density and stability of the tissue. To further facilitate clinical adoption of bioengineered skin, the fabrication technique needs to be improved in terms of standardization and automation. Read More

Int J Infect Dis 2019 Feb 19. Epub 2019 Feb 19.

Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Austria. Electronic address:

Dalbavancin, a lipoglycopeptide with prolonged half-life approved for the treatment of acute bacterial skin-and-soft-tissue-infections, can be used for the treatment of infections caused by gram-positive bacteria requiring long term treatment such as endocarditis, prosthetic joint infections (PJI) or osteomyelitis. Clinical data is limited in these settings.

Objectives: To evaluate indications, safety, tolerability and long-term outcomes of dalbavancin-treated patients. Read More

Anaerobe 2019 Feb 19. Epub 2019 Feb 19.

Section of Microbiology, University Hospital of Guadalajara, Guadalajara, Spain.

We describe the characteristics of 11 cases of skin and soft tissue infections due to Cutibacterium (formerly Propionibacterium) avidum. This microorganism should be considered a potential skin pathogen especially in patients with breast infections. The clinical outcome is usually good but serious infections such as necrotizing infections may occur. Read More

J Ethnopharmacol 2019 Feb 19. Epub 2019 Feb 19.

Centre for Complementary Medicine, Institute for Infection Prevention and Hospital Epidemiology, Faculty of Medicine, University of Freiburg, Breisacher Straße 115 B, 79106 Freiburg, Germany. Electronic address:

Ethnopharmacological Relevance: The improvement of wound healing has always been an important issue for both ethnopharmacological and modern medical research. In this study, we used state-of-the-art methods to investigate extracts of plants used traditionally in Nepal for more than 1,000 years to treat inflammatory skin injuries.

Aim Of The Study: We focused on the potential of the plant extracts to ameliorate wound healing and to influence immune modulatory properties. Read More

Eur J Pharm Biopharm 2019 Feb 19. Epub 2019 Feb 19.

Laboratory of Pharmaceutical Technology and Biopharmacy, CIRM, University of Liege, Belgium.

Nucleic acids carried by non-viral nanovectors have demonstrated high potential as a therapeutic strategy for gene-related diseases. The dermal or transdermal gene delivery allow to target local skin diseases or to reach the blood stream. However, the skin is the first defense barrier of the body and must be overcome to distribute nucleic acids. Read More

J Oral Maxillofac Surg 2019 Jan 28. Epub 2019 Jan 28.

Assistant Professor and Associate Program Director, Department of Oral and Maxillofacial Surgery, University of Rochester Medical Center, Eastman Institute for Oral Health, Rochester, NY.

Scleroderma and more generally systemic sclerosis comprise a group of autoimmune diseases characterized by increased collagen synthesis and deposition within connective tissue. The Scleroderma Foundation estimates that as many as 300,000 persons in the United States have scleroderma. Although the etiology of the disease is unknown, it is thought to be related to chronic inflammation secondary to autoimmune tissue damage. Read More

Ann Thorac Surg 2019 Feb 19. Epub 2019 Feb 19.

Paediatric Cardiology Services, Royal Brompton Hospital and Harefield NHS Foundation Trust, National Heart and Lung Institute, Imperial College London.

Few patients experience migraines following transcatheter closure of secundum atrial septal defects using nitinol devices. These are usually treated with analgesics and resolve after a few months as the device endothelialises. We report a 16 years-old male who required surgical explantation of the device 6 years after closure because of debilitating headaches. Read More

ACS Appl Mater Interfaces 2019 Feb 22. Epub 2019 Feb 22.

With the rapid development of flexible wearable electronics, piezoresistive sensor with low detection limit and wide strain sensing range turn to be great challenges for its application in this field. Here, cracked cellulose nanofibril/silver nanowire (CA) layer coated polyurethane (PU) sponge was acquired through simple dip-coating process followed by pre-compression treatment. The electrical conductivity and mechanical property of the conductive CA@PU sponge could be effective tuned through changing the dip-coating number. Read More

Genet Mol Biol 2019 Feb 21. Epub 2019 Feb 21.

Department of Surgical, Medical and Health Sciences, University of Trieste, Trieste, Italy.

Oral Lichen Planus (OLP) is an oral inflammatory condition, mediated by host immune system reaction, presenting basal membrane damages with inflammatory lesions in the mouth and/or skin. In this study, the role of functional polymorphisms in the MBL2 gene, encoding for Mannose-Binding Protein C (MBP-C), a member of the innate immune response and an acute-phase protein able to activate the complement cascade, was investigated to assess a possible association with OLP susceptibility in Italian patients. Two variations at the promoter region (called H/L and X/Y) and three at the first exon (at codon 52, 54, and 57) of the MBL2 gene were analyzed in 69 OLP patients and 244 healthy controls from northeastern Italy. Read More

PLoS One 2019 22;14(2):e0212645. Epub 2019 Feb 22.

Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

Bald thigh syndrome is a common hair loss disorder in sighthounds. Numerous possible causes, including environmental conditions, trauma, stress, endocrinopathies and genetic components have been proposed, but only endocrinopathies have been ruled out scientifically. The overall goal of our study was to identify the cause of bald thigh syndrome and the pathological changes associated with it. Read More

PLoS One 2019 22;14(2):e0211999. Epub 2019 Feb 22.

School of Physiotherapy and Exercise Science, Curtin University, Perth, Western Australia, Australia.

Objective: This pilot study assessed the efficacy of a knee guard device, which used magnetophoresis to transdermally deliver Glucosamine, Chondroitin and Hyaluronic Acid in a cohort of individuals with prior knee injury. The aim was to determine if the change in physical function and pain with the knee guard device was equivalent to the change produced by an established topical NSAID formulation containing diclofenac sodium 1%.

Methods: A randomized, controlled, equivalence trial evaluated outcomes following treatment with the knee guard device or NSAID formulation. Read More

Expert Opin Pharmacother 2019 Feb 22:1-10. Epub 2019 Feb 22.

b Section of Dermatology and Venereology, Department of Medicine , University of Verona , Verona , Italy.

Introduction: Psoriasis is a chronic inflammatory skin disease that is increasingly being recognized as a complex disorder affecting multiple systems. Systemic inflammation is considered the pathogenic link between psoriasis and its comorbid conditions that include arthritis, metabolic disorders, depression, and cardiovascular diseases. The presence of comorbid conditions modifies both its clinical management and the therapeutic approach in psoriatic patients. Read More

J Drugs Dermatol 2019 Feb;18(2):141-146

Background: Rosacea is characterized by irritation associated with erythema, telangiectasias and papules/pustules. Whole formula nature-based sensitive skin products are formulated to maintain skin barrier and appropriate hydration that can lead to soothing benefits. Objective: To evaluate the efficacy and tolerability of a regimen consisting of a cleanser containing natural oils, beeswax, and witch hazel and day and night creams containing natural oils, glycerin, and botanical anti-inflammatories (NR); and a synthetic dermatologist-recommended regimen of cetyl alcohol, sodium lauryl sulphate-containing cleanser, and glycerin, polyisobutene-containing lotion (CR) in subjects with rosacea. Read More

J Drugs Dermatol 2019 Feb;18(2):122-129

Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects around 13% of children and 7% of adults in the US. It can have a significant impact on the quality of life (QoL) of affected individuals due to pruritus and the visibility of lesions on the skin. AD is increasingly recognized as a systemic disease, since dysregulation of the adaptive and innate immune systems plays a key role in the underlying disease pathogenesis, which has important implications for how the condition is treated. Read More

Med Lav 2019 Feb 22;110(1):3-10. Epub 2019 Feb 22.

Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano.

Background: Oil refinery workers are exposed to several well-established carcinogens and working in this type of industry has been classified by IARC as probable carcinogen to humans (Group 2A).

Objectives: To examine the mortality experience of workers employed in four Italian oil refineries.

Methods: The cohort included 5112 male workers ever employed between 1949 and 2011. Read More

IEEE Trans Biomed Eng 2019 Feb 15. Epub 2019 Feb 15.

We introduce a portable system for clinical studies based on Time-Domain Diffuse Correlation Spectroscopy (TD-DCS). After evaluating different lasers and detectors, the final system is based on a pulsed laser with about 550 picosecond (ps) pulse width and a coherence length of 38 mm, and two types of single-photon avalanche diodes (SPAD). The higher efficiency of the red-enhanced SPAD maximizes detection of the collected light, increasing the signal-to-noise ratio, while the better timing response of the CMOS SPAD optimizes the selection of late photons and increases spatial resolution. Read More

Elife 2019 Feb 22;8. Epub 2019 Feb 22.

Department of Physiology and Cellular Biophysics, Columbia University, New York, United States.

Touch sensation is initiated by mechanosensory neurons that innervate distinct skin structures; however, little is known about how these neurons are patterned during mammalian skin development. We explored the cellular basis of touch-receptor patterning in mouse touch domes, which contain mechanosensory Merkel cell-neurite complexes and abut primary hair follicles. At embryonic stage 16. Read More

Curr Med Res Opin 2019 Feb 22. Epub 2019 Feb 22.

b Health Economics and Outcomes Research, Novartis Pharmaceuticals Corporation , East Hanover , NJ , USA.

Introduction: Chronic idiopathic/spontaneous urticaria (CIU/CSU) is a debilitating skin condition that is burdensome for patients and healthcare providers. We aimed to describe clinical characteristics, consultation patterns, and healthcare resource utilization in real-world US patients with refractory and non-refractory CIU/CSU.

Methods: Data were collected from the Adelphi Real World 2015 Urticaria Disease Specific Programme. Read More

Int Wound J 2019 Mar;16 Suppl 1:36-42

Biologics Division, Biopharmaceuticals and Herbal Medicine Evaluation Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju, Republic of Korea.

The aims of this randomised controlled study were to determine whether the application of silicone adhesive dressings with standard preventive care would reduce the impairment of skin integrity and to evaluate the subepidermal moisture (SEM) value in anatomical locations to predict impairment of skin integrity. Of the 71 intensive care unit patients enrolled, 35 and 31 were randomly assigned to the intervention and control groups, respectively. The SEM value was measured at each site (the coccyx, sacrum, and both buttocks) repeatedly three times at every dressing change. Read More

Pediatr Dermatol 2019 Feb 22. Epub 2019 Feb 22.

Department of Dermatology, University of Virginia Health System, Charlottesville, Virginia.

This case report presents a 17-year-old boy with Bardet-Biedl syndrome (BBS) and a long-standing hyperpigmented eruption on the left trunk and upper extremity, clinically and histologically consistent with linear porokeratosis (LP). BBS patients frequently require solid organ transplant, and subsequent immunosuppression places them at especially high risk for malignant transformation of premalignant skin lesions such as LP. Although BBS affects multiple organ systems, there are only a handful of case reports detailing associated cutaneous involvement, and, to our knowledge, this is the first reported case of linear porokeratosis occurring in patient with BBS. Read More

Pediatr Dermatol 2019 Feb 22. Epub 2019 Feb 22.

Department of Biostatistics & Bioinformatics, Duke University, Durham, North Carolina.

Objective: To quantify complications and rates of adverse events associated with surgical excision of hemangiomas in children using a national surgical database.

Data Source: Pediatric American College of Surgeons (ACS) National Surgical Quality Improvement Program (ACS NSQIP -pediatric), years 2012-2016.

Methods: Subjects included children under 18 years with a postoperative diagnosis of International Classification of Diseases (ICD), 9th revision code: 228. Read More

Rheumatology (Oxford) 2019 Feb 21. Epub 2019 Feb 21.

Muscle Disease Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, USA.

Biomater Sci 2019 Feb 22. Epub 2019 Feb 22.

Cell Therapy and Regenerative Medicine Comprehensive Center, Kerman University of Medical Sciences, Kerman, Iran. and Department of Hematology and Laboratory Sciences, Faculty of Allied Medical Sciences, Kerman University of Medical Sciences, Kerman, Iran.

The application of conventional approaches to diabetic wound regeneration has some limitations. Thus, skin substitutes could be a new therapeutic possibility. In this regard, fibrin scaffolds are promising materials due to their desirable characteristics. Read More

Expert Opin Drug Deliv 2019 Feb 22. Epub 2019 Feb 22.

a Department of Pharmaceutical Technology, Faculty of Pharmacy , University of Coimbra , Azinhaga Sta. Comba, 3000-548 Coimbra , Portugal.

Introduction: Nanotechnology is an increasingly widespread area of research for its various applications and advantages. Accordingly, nanotechnology has been the focus of investment in different areas of science, namely as a technological strategy for the development of cosmetics formulations. Nanosystems allow for a profit skin penetration and an effective release profile of ingredients, which contributes for superior technological and cosmetic effects. Read More

ACS Appl Mater Interfaces 2019 Feb 22. Epub 2019 Feb 22.

Combinatory modulation of the physical and biochemical characteristics of nanocarrier delivery systems have only begun to be investigated. Here, we studied the combined effects of incorporation of active targeting moieties into nanocarriers and their morphology affecting the enhanced permeation and retention (EPR) effect for nonomedicinal cancer therapy. Self-assembled lipid nanoparticles with low-polydispersity sub-50 nm size range and identical chemical compositions were synthesized, characterized, and correlated with in vitro cancer cellular internalization and in vivo tumor accumulation and treatments. Read More

Rev Med Liege 2019 Feb;74(2):100-103

Service de Pneumo-Allergologie pédiatrique, CHC Clinique de l'Espérance, Montegnée, Belgique.

Paracetamol (acetaminophen) is a molecule recognized worldwide for its anti-inflammatory and analgesic properties. While side effects are rare, some patients have allergic or non-allergic hypersensitivity to this molecule. Anamnesis helps to guide the diagnosis. Read More

J Tissue Eng Regen Med 2019 Feb 22. Epub 2019 Feb 22.

Cellular and Functional Biology and Biomolecules Engineering Group. School of Science, Antonio Nariño University, Bogotá, Colombia.

Platelet-rich plasma (PRP), a platelet concentrate contained in a small volume of plasma, has become a promising option in the last decade to treat different diseases related to the skin due to its high concentration of growth factors. When it is of autologous origin, it decreases the probability of suffering adverse reactions and transfusion-transmitted infections, thus it is an optimal and safe therapy for the patient. PRP has been used in the treatment of several dermatological conditions such as acne, alopecia and skin ulcers. Read More

Eur J Pain 2019 Feb 21. Epub 2019 Feb 21.

Centre for Human Drug Research, Leiden, The Netherlands.

Background: Although reproducibility is considered essential for any method used in scientific research, it is investigated only rarely; thus, strikingly little has been published regarding the reproducibility of evoked pain models involving human subjects. Here, we studied the reproducibility of a battery of evoked pain models for demonstrating the analgesic effects of two analgesic compounds.

Methods: A total of 81 healthy subjects participated in four studies involving a battery of evoked pain tests in which mechanical, thermal, and electrical stimuli were used to measure pain detection and tolerance thresholds. Read More

Wound Repair Regen 2019 Jan 11. Epub 2019 Jan 11.

Association of Dutch Burn Centres, Maasstad Hospital, Rotterdam, the Netherlands.

Scar formation is an important adverse consequence of burns. How patients appraise their scar quality is often studied shortly after sustaining the injury, but information in the long-term is scarce. Our aim was therefore to evaluate long-term patient-reported quality of burn scars. Read More

Vet Dermatol 2019 Feb 22. Epub 2019 Feb 22.

Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, 944 Garrod Dr, Davis, CA, 95616, USA.

Background: Hamsters are popular companion animals which may present to veterinarians for treatment of skin diseases. Most descriptions of dermatoses in hamsters have primarily been in case reports and in text books.

Hypothesis/objectives: To document skin diseases and their prevalence in companion hamsters examined in northern California, USA, and Nantes, France, and to investigate predilections for the most common conditions documented in medical records over a 33 year or 15 year period, respectively. Read More

Contact Dermatitis 2019 Feb 21. Epub 2019 Feb 21.

Allergy Section, Hospital General Universitario., Ciudad Real, Spain.

A 51-year-old female patient was treated with Pregabalin (Lyrica) 25 mg/day for 3 weeks and 75 mg/day during a 4th week). After a month of treatment, a maculopular rash developed in the nape, neck, ears, arms knees and ankles which improved after the withdrawal of the drug and administration of deflazacort 30 mg for 5 days. This article is protected by copyright. Read More

Curr Allergy Asthma Rep 2019 Feb 22;19(2):11. Epub 2019 Feb 22.

Division of Allergy and Immunology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave., Boston, MA, 02115, USA.

Purpose Of Review: Pediatric drug hypersensitivity is a rapidly evolving field. The purpose of this paper is to review the current state of pediatric drug hypersensitivity and highlight new developments in diagnosis and management.

Recent Findings: This paper will discuss the safety and use of risk stratification to proceed directly to oral challenge without prior skin testing for β-lactam reactions. Read More

Mil Med 2019 Feb 22. Epub 2019 Feb 22.

Naval Hospital Jacksonville, 2080 Child Street, Jacksonville, FL.

Introduction: The identified number of isolated populations with unique medical characteristics is growing. These populations are difficult to study. Civil-military humanitarian operations are part of our medical force readiness training, and are also a venue through which unique populations can be simultaneously served and evaluated. Read More

Prev Med Rep 2019 Mar 28;13:346-353. Epub 2018 Dec 28.

University of Pennsylvania Perelman School of Medicine, 423 Guardian Drive, Blockley Hall, Philadelphia, PA 19104, United States of America.

Although skin cancer incidence is highest among non-Hispanic Whites, minority populations are often diagnosed with more advanced stage disease and are more likely to experience poor outcomes. Fewer people of color do not practice primary prevention of skin cancer according to recommendations, but public health education and interventions to promote sun protection behaviors have consistently targeted non-Hispanic Whites. This study examines performance of sun protection behaviors in a multiethnic sample and whether demographic, lifestyle and psychosocial predictors of these behaviors differ by race and ethnicity. Read More

Case Rep Dermatol Med 2019 16;2019:3730915. Epub 2019 Jan 16.

Department of Anatomy-Histology-Embryology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.

Most primary cutaneous B-cell lymphomas (PCBCL) are CD5 negative, and only a few cases were found to express CD5. We report the first well-documented CD5+ primary cutaneous diffuse large B-cell lymphoma-leg type (PCDLBCL-LT). A 71-year-old woman with a history of Multiple Sclerosis was admitted because of a nodule at the left thigh. Read More

Digit Health 2019 Jan-Dec;5:2055207619828225. Epub 2019 Feb 6.

Dermatology Research Centre, The University of Queensland, The University of Queensland Diamantina Institute, Brisbane, Queensland, Australia.

Objective: The aim of the study is to evaluate healthcare practitioners' views on and satisfaction with (i) digital image acquisition and storage and (ii) store-and-forward teledermoscopy services for the diagnosis of skin cancer in their clinical practice.

Methods: An online survey was conducted among 59 healthcare practitioners (GPs (=17), dermatologists (=22), dermatology registrars (=18), a dermatology research fellow (=1) and a plastic surgeon (=1)) to assess usability of digital image acquisition and storage for when the imaging process is conducted by the healthcare practitioners themselves, or by their patients. The study identifies the enablers and barriers of this emerging mode of medical practice. Read More

Clin Transl Allergy 2019 11;9. Epub 2019 Feb 11.

1Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, Poland.

Background: Links between multimorbidity of allergic diseases and allergen sensitization are still under debate, especially in adults. This study aimed to establish a relationship between polysensitization and allergic multimorbidity in children and adults and the allergens involved in multimorbidity.

Material And Method: A cross-sectional multicentre study enrolled children aged 6-7 and 13-14 years and adults aged 20-44 years from a Polish national cohort. Read More

Front Immunol 2019 7;10:139. Epub 2019 Feb 7.

Biosciences Department, Durham University, Durham, United Kingdom.

Front Immunol 2019 7;10:114. Epub 2019 Feb 7.

Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States.

Although the relevance of humoral immunity for protection against skin and soft tissue infections (SSTIs) has been suggested by several animal and human studies, the question of which human antibodies may be protective has so far impeded the development of a safe and effective vaccine. Because most adults have developed certain anti- antibodies due to colonization or infection, we hypothesized that the titers of antibodies to in uninfected controls would differ from those in infected patients and would also differ in infected patients from the time of acute infection to a 40-day convalescent serum. To test these hypotheses, we measured human antibody levels against a panel of 134 unique antigens comprising the surfome and secretome in subjects with active culture-confirmed SSTIs (cases) and in controls with no infection, using a novel protein microarray. Read More

Front Microbiol 2019 7;10:16. Epub 2019 Feb 7.

Jes Tech, KBR Wyle Laboratories Houston, Houston, TX, United States.

Latent herpes virus reactivation has been demonstrated in astronauts during shuttle (10-16 days) and International Space Station (≥180 days) flights. Following reactivation, viruses are shed in the body fluids of astronauts. Typically, shedding of viral DNA is asymptomatic in astronauts regardless of mission duration; however, in some cases, live/infectious virus was recovered by tissue culture that was associated with atopic-dermatitis or skin lesions during and after spaceflight. Read More

Front Neurol 2019 7;10:79. Epub 2019 Feb 7.

Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.

Melanocytic nevi present at birth, or within the first few months of life, are defined as congenital melanocytic nevi (CMN). Neurocutaneous melanosis (NCM) is a rare disorder, represents pigment cell tumors of the leptomeninges, and occurs in association with large or multiple CMN. NCM carries an extremely poor prognosis. Read More

Case Rep Oncol 2019 Jan-Apr;12(1):84-90. Epub 2019 Jan 21.

Division of Medical Oncology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.

Common dermatological side-effects associated with erlotinib, epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), include pruritus and skin rash, which are mediated by substance P, leading to the occasional discontinuation of cancer treatment. Aprepitant is an antagonist of neurokinin-1 receptor, through which substance P activates the pruritogens. Thus, aprepitant is expected to offer a promising option for the treatment of erlotinib-induced pruritus. Read More

Case Rep Oncol 2019 Jan-Apr;12(1):22-28. Epub 2019 Jan 4.

Klinik für Innere Medizin II, Hämatologie und internistische Onkologie, Universitätsklinikum Jena, Jena, Germany.

Infectious complications such as invasive aspergillosis or infection with (SM) in immunocompromised patients are associated with a high mortality rate. Our report concerns a 40-year-old male newly diagnosed very severe aplastic anemia (vSAA) who in consequence of a mosquito bite was suffering from skin lesion and consecutive soft tissue phlegmon subsequent to the administration of antithymocyte globulin; a full-thickness autologous meshed skin graft successfully performed to cover skin ulcera after allogeneic stem cell transplantation (SCT). This unusual case illustrates the importance of appropriate diagnosis, anti-infective therapy and close interdisciplinary diagnostic algorithms to minimalize side effects and the selection of resistant strains and to improve patients' outcome. Read More

Clin Med Insights Case Rep 2019 7;12:1179547619828723. Epub 2019 Feb 7.

Department of General Surgery, Indira Gandhi Medical College, Shimla, India.

Aggressive digital papillary adenocarcinoma (ADPA) is a rare tumour of eccrine origin. They present as asymptomatic nodules with flattened and thickened surface skin, most commonly on fingers and toes. It mimics many benign entities and tumours, hence leading to a delay in diagnosis. Read More

Sci Rep 2019 Feb 21;9(1):2524. Epub 2019 Feb 21.

Institute of Medical Biology, A*STAR, Singapore, 138684, Singapore.

Superresolution microscopy offers the advantage of imaging biological structures within cells at the nano-scale. Here we apply two superresolution microscopy techniques, specifically 3D structured illumination microscopy (3D-SIM) and direct stochastic optical reconstruction microscopy (dSTORM), a type of single molecule localisation microscopy, to localise IRSp53 protein and its I-BAR domain in relation to F-actin within filopodia. IRSp53 generates dynamic (extending and retracting) filopodia 300 nm wide with a distinct gap between IRSp53 and F-actin. Read More

Eur Respir J 2019 Feb 20. Epub 2019 Feb 20.

Montreal Chest Institute, McGill University Montreal, Canada.

Health care workers (HCWs) are at increased risk of latent tuberculosis infection (LTBI) and TB disease. We conducted an updated systematic review of the prevalence and incidence of LTBI in HCWs in low and middle-income countries (LMICs), associated factors, and infection control practices. We searched Medline, Embase, and Web of Science (01 January 2005-20 June 2017) for studies published in any language. Read More

Pediatrics 2019 Feb 21. Epub 2019 Feb 21.

Division of Pediatric Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas, Texas

Giant congenital nevi are melanocytic proliferations of the skin that may be complicated by melanoma, neurocutaneous melanocytosis, pain, pruritus, and disfigurement. Current treatment options include surgical resection and medical management of associated symptoms. There is limited efficacy in these modalities. Read More

J Prosthodont Res 2019 Feb 18. Epub 2019 Feb 18.

Section "Medical Materials Science and Technology", Tuebingen University Hospital, Tuebingen, Germany.

Purpose: To set up the digital database (DDB) of various anatomical parts, skin details and retention elements in order to simplify the digital workflow of facial prostheses manufacturing; and to quantify the reproduction of skin wrinkles on the prostheses prototypes with stereolithography (SLA) and direct light processing (DLP) methods.

Methods: Two structured light scanners were used to obtain the nasal and auricle forms of 50 probands. Furthermore, the ala nasi and scapha areas were captured with the digital single lens reflex camera and saved in jpeg format. Read More

J Dermatol Sci 2019 Jan 26. Epub 2019 Jan 26.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8575, Japan. Electronic address:

Background: The main pathogenesis of acne vulgaris is increase in sebum production and abnormal keratinization of the hair infundibulum. The androgens are involved in acne pathogenesis by modulating sebaceous glands to enhance sebum production. However, the molecular mechanisms of abnormal keratinization of the hair infundibulum are not fully elucidated. Read More