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BMJ Case Rep 2022 Jun 20;15(6). Epub 2022 Jun 20.

Department of Surgery, University of the Philippines-Philippine General Hospital, Manila, Metro Manila, Philippines.

Basal cell carcinoma (BCC) is a common skin malignancy and usually occurs in sun-exposed areas like the head and neck. Occurrence in the perianal area is rare, accounting for only 0.08% of all BCC, and 0. Read More

Front Oncol 2022 23;12:846278. Epub 2022 May 23.

Moores Cancer Center, University of California, San Diego, La Jolla, CA, United States.

Background: The recent addition of immunotherapy as a treatment modality to surgery and radiation has vastly improved disease control for patients with keratinocyte-derived carcinomas (KCs) that are incurable with local therapies alone. With the advent of immune checkpoint inhibitors (ICPis) in non-melanoma skin cancers comes diagnostic and therapeutic challenges when considering treatment strategies for patients presenting with clinical perineural invasion (cPNI) of locally advanced KC of the head and neck.

Objectives: We report four cases that convey the diagnostic and therapeutic complexity of managing patients with neuropathic symptoms from cutaneous neurotropic carcinomas of the head and neck. Read More

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Mar;47(3):384-389

Department of Plastic and Cosmetic Surgery, Xiangya Hospital, Central South University, Changsha 410008.

Nevus-like basal cell carcinoma syndrome (NBCCS) is a rare autosomal dominant disease characterized by the occurrence of multiple maxillofacial keratocysts, basal cell carcinoma, child medulloblastoma, and various skeletal and soft tissue dysplasia. In 2020, a patient with NBCCS dominated by facial basal cell carcinoma was admitted to Xiangya Hospital of Central South University. The patient was an elderly woman. Read More

JPRAS Open 2022 Jun 10;32:88-92. Epub 2022 Mar 10.

Department of Plastic and Reconstructive Surgery, Kansai Medical University, Osaka, Japan.

We herein report a 57-year-old man afflicted with multiple malignant tumors arising from a giant sebaceous nevus on his left parieto-temporal scalp and neck. The upper eyelid was resected in all layers, and the auricle was resected as well, leaving part of the external auricular cartilage; the parotid gland area was also resected over the parotid fascia. The lost part of the left eyebrow was reconstructed using an anterior forehead skin flap, and the residual defect was covered with skin graft and expanded scalp flap. Read More

Sci Rep 2022 03 22;12(1):4891. Epub 2022 Mar 22.

Department of Burn Plastic and Aesthetic Surgery, General Hospital of Ningxia Medical University, No. 804, Shengli South Street, Xingqing District, Yinchuan, 750001, China.

Large eyelid defect after excision of malignancies or trauma is difficult to reconstruct due to special structure and function of the eyelid. In this study, we aimed to present the outcomes of subcutaneous pedicled propeller flap for reconstructing the large eyelid defect after excision of malignancies or trauma. A retrospective review of patients diagnosed with eyelid defect due to excision of malignancies or trauma, and undergoing subcutaneous pedicled propeller flap for reconstructing the large eyelid defect, was conducted at our hospital. Read More

Am J Dermatopathol 2022 May;44(5):e54-e56

Department of Dermatopathology, University of Virginia, Charlottesville, VA.

Abstract: Neurocristic hamartomas (NCH) of cutaneous origin are especially rare congenital or acquired neoplasms that often arise through aberrant embryologic development of pluripotent neural crest cells. Clinically, they often present as pigmented macules or papules on the scalp with associated alopecia. NCHs are characterized histopathologically by dermal melanocytic, fibroblastic, and neurosustentacular components. Read More

Int Ophthalmol 2022 Jun 28;42(6):1867-1874. Epub 2022 Jan 28.

Department of Ophthalmology and Visual Sciences, Division of Ophthalmic Plastic and Reconstructive Surgery, Paulista School of Medicine, Federal University of São Paulo, São Paulo, SP, Brazil.

Objective: The incidence of malignant eyelid tumors is considerably increasing, even in young patients. The purpose of this study was to identify particularities in individuals under 40 years of age affected by eyelid malignancies.

Methods: Clinical charts of patients under 40 years of age who underwent eyelid tumor excision from 2014 to 2020 in two reference centers, one in Brazil and one in the USA, were reviewed. Read More

J Eur Acad Dermatol Venereol 2022 06 3;36(6):e460-e464. Epub 2022 Feb 3.

Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

J Pathol 2022 05 28;257(1):96-108. Epub 2022 Mar 28.

CARADERM Network, Pau, France.

We report 21 cases of trichogerminoma harbouring previously undescribed FOXK1::GRHL1/2 or GPS2::GRHL1/2/3 in-frame fusion transcripts. Microscopic examination of a preliminary set of five cases revealed well-delimitated tumours located in the dermis with frequent extension to the subcutaneous tissue. Tumours presented a massive and nodular architecture and consisted of a proliferation of basaloid cells. Read More

Arch Craniofac Surg 2022 Feb 10;23(1):17-22. Epub 2022 Jan 10.

Department of Plastic and Reconstructive Surgery, Pusan National University School of Medicine, Busan, Korea.

Background: Reconstruction of large facial defects is challenging as both functional and cosmetic results must be considered. Reconstruction with forehead flaps on the face is advantageous; nonetheless, reconstruction of large defects with forehead flaps alone results in extensive scarring on the donor site. In our study, the results of reconstruction using a combination of forehead flaps and other techniques for large facial defects were evaluated. Read More

In Vivo 2022 Jan-Feb;36(1):251-257

Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, U.S.A.;

Background/aim: It is estimated that nonmelanoma skin cancer (NMSC), including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), affects more than 3 million Americans each year. Translation of next-generation sequencing (NGS) data into identification of new potential targets for therapeutic applications may be helpful. Whole-exome sequencing (WES) is a widely used NGS method that involves sequencing the protein-coding regions of the genome. Read More

World J Surg Oncol 2021 Dec 24;19(1):350. Epub 2021 Dec 24.

Department of Plastic Surgery, Medical School, University of Ioannina, Leoforos St. Niarchou, 45110, Ioannina, Greece.

Background: The outbreak of COVID-19 pandemic led to a 2-month lockdown in Europe. Elective surgeries, including skin cancer excisions, were postponed. The purpose of this prospective case-control study was to assess the impact of the treatment delay on patients with non-melanoma skin cancer (NMSC) or melanoma operated in the first post-lockdown period. Read More

J Surg Case Rep 2021 Dec 20;2021(12):rjab560. Epub 2021 Dec 20.

Department of Plastic Surgery, St. Savvas Anticancer-Ongologic Hospital of Athens, Athens, Greece.

Collision tumors are neoplasms coexisting in the some anatomical area. The most common combination is melanocytic nevus with basal cell carcinoma. Melanocytic nevus with basal cell carcinoma constitutes the most common cutaneous combination. Read More

Dermatol Surg 2021 12;47(12):1660-1661

Department of Dermatology and Mohs Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

J Dtsch Dermatol Ges 2021 11;19(11):1571-1580

Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Innsbruck, Innsbruck, Austria.

Squamous cell carcinoma is the second most common malignancy of the skin after basal cell carcinoma and mainly found in sun-exposed areas such as the face. This mostly locally destructive malignancy may show invasive growth and insidious mechanisms of dissemination such as perineural invasion. Periorbital squamous cell carcinoma is associated with perineural invasion in up to 14 % of cases. Read More

Int J Mol Sci 2021 Oct 23;22(21). Epub 2021 Oct 23.

ZIK Plasmatis, Leibniz Institute for Plasma Science and Technology (INP), Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany.

Reactive oxygen species (ROS) have been subject of increasing interest in the pathophysiology and therapy of cancers in recent years. In skin cancer, ROS are involved in UV-induced tumorigenesis and its targeted treatment via, e.g. Read More

Am J Ophthalmol 2022 04 23;236:164-171. Epub 2021 Oct 23.

Genentech, Inc. (K.B, C.S.M, A.S, J.L., EM), South San Francisco, California, USA.

Purpose: To date, there are no studies on healthcare resource utilization (HRU) and costs for treating periocular basal cell carcinoma (pBCC). We investigated real-world HRU and costs of patients with limited versus extensive pBCC.

Design: This was a retrospective cost analysis. Read More

PeerJ 2021 24;9:e12234. Epub 2021 Sep 24.

Department of Nursing, Faculty of Medicine and Health Sciences, University of Extremadura, Badajoz, Extremadura, Spain.

Background: Skin cancer is one of the common malignancies. There is sufficient evidence that sunlight (ultraviolet radiation) contributes to the development of skin cancer, but there is also evidence that relates adequate serum levels of vitamin D produced on the skin by the action of ultraviolet radiation with the decreased risk of various types of cancers, including skin cancer. The aim of this study was to investigate the association of vitamin D serum levels among patients with non-melanoma skin cancers (basal cell carcinoma and squamous cell carcinoma) and controls. Read More

Int J Dermatol 2022 07 10;61(7):e269-e270. Epub 2021 Oct 10.

Department of Reconstructive and Aesthetic Plastic Surgery, "Campus Bio-Medico di Roma" University, Rome, Italy.

Ophthalmic Genet 2022 02 5;43(1):27-35. Epub 2021 Oct 5.

Department of Human and Molecular Genetics, Virginia Commonwealth University Health System, Richmond, VA, USA.

Background: Nevoid basal cell carcinoma syndrome (NBCCS) is a rare genetic disorder associated with basal cell carcinomas (BCC), skeletal anomalies, and jaw cysts, and a number of ocular abnormalities. We describe a case of a 12-year-old boy diagnosed with NBCCS found to have several ophthalmic manifestations including a myelinated retinal nerve fiber. We conducted a literature review targeting the ocular and systemic manifestations of NBCCS, with a focus on the ophthalmic findings that have not been well characterized. Read More

J Plast Reconstr Aesthet Surg 2021 Nov 14;74(11):3196-3211. Epub 2021 Sep 14.

g; Welsh Centre for Burns and Plastic Surgery Morriston Hospital, Swansea United Kingdom.

Psychooncology 2022 02 14;31(2):238-244. Epub 2021 Sep 14.

Department of Plastic and Reconstructive Surgery, Catharina Hospital, Eindhoven, The Netherlands.

Objective: Nonmelanoma skin cancer (NMSC) is one of the most diagnosed cancers in the world, with the number of new occurrences rising every year. Most patients with facial skin cancer experience cancer-related worry. Yet, little is known about their worry during the period after cancer treatment. Read More

J Craniofac Surg 2022 May 10;33(3):e287-e290. Epub 2021 Sep 10.

Department of Burns, Plastic, Maxillofacial and Microvascular Surgery, Lok Nayak Hospital, New Delhi, India.

Aim: To describe a series of medial canthal defect reconstruction by local/loco-regional flaps following excision of basal cell carcinoma.

Material And Methods: A series of 35 medial canthal defects following excision of basal cell carcinoma was reconstructed by local/loco-regional flaps. For smaller defects, glabellar lateral advancement flap or Limberg's flap from the nasolabial area were used to resurface the defects. Read More

Cesk Slov Oftalmol 2021 ;77(4):208-213

Aim: We present the management of a severe case of recurrent periocular basal cell carcinoma, orbital invasion and exenteration.

Case Report: The present case is of a recurrent basal cell carcinoma in a 84-year-old male presenting with non-healing lesion above right eyelid. A tumor excision was performed in May 2014. Read More

Acta Dermatovenerol Croat 2021 Apr;291(1):8-20

Sanda Smuđ Orehovec, MD, Division of Plastic and Reconstructive Surgery and Breast Surgery , Department of Surgery, Clinical Hospital Centre Zagreb, Kišpatićeva 12, 10000 Zagreb, Croatia;

The most common nonmelanoma skin cancers (NMSC) are basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The incidence of NMSC is 18-20 times higher than the incidence of melanoma. The Cyclooxygenase-2 (COX-2) and Matrix Metalloproteinase-1 (MMP-1) enzymes have both been linked to the development of these diseases but their exact significance is unknown. Read More

Br J Dermatol 2021 11 2;185(5):877. Epub 2021 Sep 2.

Department of Oncology, Norfolk and Norwich University Hospital, Norwich, UK.

Br J Cancer 2022 03 1;126(4):562-568. Epub 2021 Sep 1.

Department of Plastic and Reconstructive Surgery, Norfolk and Norwich University Hospital NHS Foundation Trust, Norwich, UK.

Background: Basal cell carcinoma (BCC) is the most common human cancer. Facial BCCs most commonly occur on the nose and the management of these lesions is particularly complex, given the functional and complex implications of treatment. Multidisciplinary team (MDT) meetings are routinely held to integrate expertise from dermatologists, surgeons, oncologists, radiologists, pathologists and allied health professionals. Read More

Dermatol Surg 2021 12;47(12):1634-1635

Department of Plastic and Reconstructive Surgery, School of Medicine, Chungnam National University, Daejeon, South Korea.

ANZ J Surg 2021 Dec 30;91(12):2744-2749. Epub 2021 Aug 30.

Plastic Surgery North Shore, Auckland, New Zealand.

Background: Surgical skin specimens are known to undergo significant shrinkage when excised and processed. The degree of shrinkage is important for medical care, research and third-party assessment. Studies to date have shown variable degrees of shrinkage. Read More

J Eur Acad Dermatol Venereol 2021 Oct 25;35(10):1949-1956. Epub 2021 Aug 25.

Institute of Dermatology, Catholic University of the Sacred Heart, Italy.

Background: No simple classification system has emerged for 'advanced basal cell carcinomas', and more generally for all difficult-to-treat BCCs (DTT-BCCs), due to the heterogeneity of situations, TNM inappropriateness to BCCs, and different approaches of different specialists.

Objective: To generate an operational classification, using the unconscious ability of experts to simplify the great heterogeneity of the clinical situations into a few relevant groups, which drive their treatment decisions.

Method: Non-supervised independent and blinded clustering of real clinical cases of DTT-BCCs was used. Read More