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BMJ Case Rep 2021 Apr 23;14(4). Epub 2021 Apr 23.

Department of Pathology, Japanese Red Cross Akita Hospital, Akita, Japan.

Basal cell carcinoma (BCC) showing signet ring (SR) cell morphology is a very rare variant of BCC. Here, we report BCC with SR cell morphology developed in the right cheek skin of a 79-year-old man. Histopathologic examination showed irregularly shaped islands of basaloid cells with characteristic peripheral palisading. Read More

BMJ Case Rep 2021 Jan 26;14(1). Epub 2021 Jan 26.

Department of Otolaryngology, Division of Facial Plastic & Reconstructive Surgery, University of Virginia, Charlottesville, Virginia, USA.

Nasal reconstruction following a total or subtotal resection presents a challenging clinical scenario. Ample external skin coverage is readily available using the paramedian forehead flap (PMFF), but restoring adequate internal lining of sufficient size and pliability is a major limitation. Intranasal mucosal flaps or free tissue transfer is often employed for this purpose, each with their own sets of limitations. Read More

Medicine (Baltimore) 2020 Dec;99(51):e23789

Department of Plastic and Reconstructive Surgery.

Abstract: Skin cancer diagnoses are rising due to increasing ultraviolet ray exposure and an aging population. The complete surgical excision of skin cancer, including a normal tissue, has been the widely performed and determining the adequate safety margin is essential. In this study, we compared the preoperative thickness and width of skin cancer by ultrasonography with the measurements by histopathologic findings. Read More

BMJ Case Rep 2020 Dec 21;13(12). Epub 2020 Dec 21.

Plastic Surgery, Whiston Hospital, Prescot, UK.

Br J Dermatol 2021 01 16;184(1):e4. Epub 2020 Dec 16.

National Xeroderma Pigmentosum Service, St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, UK.

J Clin Med 2020 Nov 25;9(12). Epub 2020 Nov 25.

Department of Nursing, Faculty of Medicine, University of Extremadura, Badajoz, 06006 Extremadura, Spain.

Exposure to sunlight is the major source of vitamin D and the main environmental cause of non-melanocytic skin cancers. Vitamin D, partly mediated through the vitamin D receptor (VDR), has potential therapeutic applications in skin cancer. The aim of this study was to investigate the association of and VDR polymorphisms among patients with non-melanoma cancers and controls. Read More

Medicina (Kaunas) 2020 Nov 25;56(12). Epub 2020 Nov 25.

Department of Translational Research and New Technologies in Medicine and Surgery, Plastic Surgery Unit, University of Pisa, 56125 Pisa, Italy.

The nose represents the most common site for the presentation of cutaneous cancer, especially in sun-exposed areas: ala, dorsum, and tip. Even the smallest loss of substance can create aesthetic and psychosocial concerns for patients; therefore, surgeons who perform nasal reconstruction should be strictly confident with the pertinent surgical anatomy in order to tailor the procedure to the patient's condition and needs. Radical tumor excision and satisfactory aesthetic and functional results are primary targets. Read More

J Plast Reconstr Aesthet Surg 2021 03 1;74(3):644-710. Epub 2020 Nov 1.

Department of Plastic and Reconstructive Surgery, Royal Free NHS Foundation Trust London, United Kingdom.

Minerva Stomatol 2020 Nov 18. Epub 2020 Nov 18.

Maxillo-Facial Surgery Unit, University of Campania Luigi Vanvitelli, Naples, Italy.

Background: Most nasal cutaneous malignancies occur on the caudal third of the nose. Commonly, following resective surgery, the surgeon is requested to reconstruct the ala. Small skin defects of the nose may be left healing by secondary intention, although this may sometimes create an unpleasant scar. Read More

Int J Mol Sci 2020 Nov 14;21(22). Epub 2020 Nov 14.

Department of Onco-Hematology, Unit of Medical Oncology, Centro di Riferimento Oncologico della Basilicata (IRCCS-CROB), 85028 Rionero in Vulture, Italy.

Cutaneous basal cell carcinoma (BCC) is the most common type of human tumor, and its incidence rate is increasing worldwide. Up until a few years ago, therapeutic options have been limited for patients with advanced BCC (including metastatic and locally-advanced BCC). Over the last few years, promising systemic therapies have been investigated for the treatment of advanced BCC. Read More

J Plast Reconstr Aesthet Surg 2021 03 2;74(3):644-710. Epub 2020 Nov 2.

Department of Plastic and Reconstructive Surgery, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Castle Road, Cottingham HU16 5JQ, England.

J Plast Reconstr Aesthet Surg 2021 04 7;74(4):890-930. Epub 2020 Nov 7.

Department of Plastic Surgery, Cambridge University Hospitals NHS Trust, Cambridge CB2 0QQ, United Kingdom; Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, United Kingdom. Electronic address:

World J Mens Health 2020 Aug 28. Epub 2020 Aug 28.

Department of Urology, Tianjin Medical University General Hospital, Tianjin, China.

Purpose: We conducted a systematic review and meta-analysis to quantify the association between phosphodiesterase type 5 inhibitors (PDE5Is) use and skin cancers and we also examined whether down-expression of the PDE5A gene was related to worse prognosis for malignant melanoma (MM) patients.

Materials And Methods: The PubMed, Cochrane Library, Web of Science, EMBASE, and ClinicalTrails.gov databases were searched. Read More

Arch Craniofac Surg 2020 Oct 20;21(5):315-318. Epub 2020 Oct 20.

Department of Plastic and Reconstructive Surgery, Konkuk University Chungju Hospital, Konkuk University School of Medicine, Chungju, Korea.

Side effects of tattoos can occur due to unexpected body responses. Concerns about the side effects of tattoos are growing concomitantly with the increasing number of tattooed individuals. We report a rare case of basal cell carcinoma (BCC) on a tattooed eyebrow. Read More

J Cancer Res Ther 2020 Sep;16(5):1051-1055

Department of Plastic and Cosmetic Surgery, Daping Hospital, Army Military Medical University, Chongqing, China.

Purpose: The purpose of this study is to investigate the clinical efficacy of Mohs surgery in combination with topical photodynamic therapy (PDT) for facial basal cell carcinoma.

Patients And Methods: Eighty-six patients with facial basal cell carcinoma treated in our department from April 2011 to December 2013 were included. Mohs surgery was used to remove the lesions followed by direct suturing, skin flap grafting, or medium thickness free-skin grafting to repair the incisions. Read More

J Dermatol 2021 Jan 24;48(1):96-100. Epub 2020 Sep 24.

Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.

A case of xeroderma pigmentosum (XP) group D in a 39-year-old Japanese man is reported. The patient had suffered from moderate to severe solar sensitivity and freckle-like pigmented macules in sun-exposed areas since 6 years of age, and developed skin malignancies such as squamous cell carcinoma, actinic keratosis, Bowen's disease and basal cell carcinoma. The minimal erythema dose for ultraviolet (UV) radiation was decreased with a delayed peak reaction. Read More

Eur J Cancer 2020 11 19;140:151-153. Epub 2020 Sep 19.

Department of Otolaryngology Head and Neck Surgery, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. Electronic address:

Dermatol Surg 2021 02;47(2):184-188

Department of Dermatology, University of California, Irvine, California.

Background: The primary endpoint for surgical excision of skin cancer is the positive margin status. Tumor characteristics may explain much of this risk, but other important factors can include physician specialty.

Objective: To determine the variables affecting the success of a basal cell carcinoma (BCC) or melanoma in situ (MIS) excision. Read More

Acta Chir Plast 2020 ;62(1-2):4-9

Introduction: Diagnosis of malignant cutaneous tumours of the hand is often difficult because of the different anatomic structures present in this region and yet clinicians must be able to distinguish typical benign entities from life-threatening or limb-threatening malignant diseases. Due to the hand's complex structures located in a small area, surgeons must evaluate constantly the balance of inadequate surgery against functional and cosmetic aspects. Thus, a multidisciplinary approach is recommended for a correct diagnosis and treatment design. Read More

Aging (Albany NY) 2020 08 14;12(15):15328-15333. Epub 2020 Aug 14.

Department of Burn and Plastic Surgery, Huaian First People's Hospital, Huaian, Jiangsu, China.

To explore the association between the IL-6 -174 G/C polymorphism and the risk of basal cell carcinoma (BCC) in a Chinese population, we performed a case-control study involving 265 BCC patients and 341 controls. Genotyping was performed using polymerase chain reaction with sequence-specific primers. The data showed that the GG+CG and GG genotypes were associated with an increased risk of BCC. Read More

Harefuah 2020 Aug;159(8):541-544

Department of Plastic Surgery, "Emek" Medical Center, Afula, Israel.

Aims: This study aimed at demonstrating whether the histological and clinical manifestations of pigmented basal cell carcinoma are different among those who were previously treated with ionizing radiation for ringworm infection.

Background: Ionizing radiation is known to cause increased morbidity among those who are chronically exposed. Basal cell carcinoma in known to be related to ionizing radiation however, the characteristics of pigmented BCC in relation to ionizing radiation are poorly described. Read More

Eur J Cancer 2020 10 21;138:30-40. Epub 2020 Aug 21.

Department of Oncology, Herlev and Gentofte Hospital, University of Copenhagen, Herlev, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; Department of Clinical Oncology and Palliative Care, Zealand University Hospital, Roskilde, Denmark. Electronic address:

Background: Electrochemotherapy (ECT) is a treatment for both primary and secondary cutaneous tumours. The international Network for sharing practices on ECT group investigates treatment outcomes after ECT using a common database with defined parameters.

Methods: Twenty-eight centres across Europe prospectively uploaded data over an 11-year period. Read More

Int J Mol Sci 2020 Jul 29;21(15). Epub 2020 Jul 29.

Section of Medical Oncology, Department of Biomedical Sciences and Clinical Oncology (DIMO), University of Bari 'Aldo Moro', 70121 Bari, Italy.

Non-melanoma skin cancers (NMSCs) include basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and Merkel cell carcinoma (MCC). These neoplasms are highly diverse in their clinical presentation, as well as in their biological evolution. While the deregulation of the Hedgehog pathway is commonly observed in BCC, SCC and MCC are characterized by a strikingly elevated mutational and neoantigen burden. Read More

Dermatol Ther 2020 11 14;33(6):e14094. Epub 2020 Aug 14.

Department of Dermatology, Faculty of Medicine, Manisa Celal Bayar University, Manisa, Turkey.

Skin cancers are the most common type of cancer. Nonmelanoma skin cancers (NMSCs) are more common than melanoma. Although the mortality rate is low, cancer word can be frightening for patients. Read More

Arch Craniofac Surg 2020 Jun 29;21(3):202-205. Epub 2020 Jun 29.

Department of Plastic and Reconstructive Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.

Trichoepithelioma is a benign hair follicle tumor that can undergo malignant transformation into basal cell carcinoma in rare cases. Due to the similar clinical and histological features of trichoepithelioma and basal cell carcinoma, distinguishing between these types of tumors can be a diagnostic challenge. Punch biopsy obtains only a small sample of the entire lesion, and thus inherently involves a risk of misdiagnosis between histologically similar diseases. Read More

Arch Craniofac Surg 2020 Jun 29;21(3):188-192. Epub 2020 Jun 29.

Department of Plastic and Reconstructive Surgery, Konkuk University Chungju Hospital, Konkuk University School of Medicine, Chungju, Korea.

The most common forms of nonmelanocytic skin cancer (NMSC) are basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The growing incidence of skin cancer in the Republic of Korea has sparked increasing scientific interest in these types of tumors. In the case described herein, multiple NMSCs occurred asynchronously in various areas of the body in a single patient. Read More

Saudi Med J 2020 Jul;41(7):709-714

Division of Plastic Surgery, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia. E-mail.

Objectives: To assess the prevalence of melanoma and non-melanoma skin cancer for patients attended King Khalid University Hospital, Riyadh, Saudi Arabia. We are also assessing the most common category of skin cancer to be encountered among those patients. Methods: The authors conducted a retrospective study including all patients (Saudi and non-Saudi) who attended King Khalid University Hospital (KKUH) at the period of (2007-2018). Read More

J Otolaryngol Head Neck Surg 2020 Jun 1;49(1):33. Epub 2020 Jun 1.

Department of Otolaryngology - Head and Neck Surgery, London Health Sciences Centre, Victoria Hospital, University of Western Ontario, 800 Commissioners Road E, London, ON, N6A 5W9, Canada.

Background: Hydrogen peroxide (HO) is a product of respiration in mitochondria and an important oxidizing agent in biological systems. Previous investigations have shown the efficacy of HO in treating skin conditions such as seborrheic keratosis and actinic keratosis. In an area like the face, reconstruction of excision defects and ultimately aesthetic outcomes are of utmost importance. Read More

J Surg Case Rep 2020 May 23;2020(5):rjaa082. Epub 2020 May 23.

Division of Plastic Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA.

Mild- to moderate-sized lip defects that affect one- to two-thirds of the total lip length often require that utilization of local soft tissue rearrangement in order to re-establish lip anatomy, function and esthetics. The use of local flaps in lip reconstruction often follows oncologic resection of common skin malignancies including basal cell carcinoma and squamous cell carcinoma. When considering the types of flaps to use for lip defects of one- to two-third total length, a variety of flaps designs have been described, each with its benefits in drawbacks. Read More

Dermatol Ther 2020 07 22;33(4):e13674. Epub 2020 Jun 22.

Medical Faculty, Johannes Kepler University Linz, Linz, Austria.