Search our Database of Scientific Publications and Authors

I’m looking for a

    216 results match your criteria Skin Lightening and Depigmenting Agents

    1 OF 5

    N-(4-methoxyphenyl) caffeamide-induced melanogenesis inhibition mechanisms.
    BMC Complement Altern Med 2017 Jan 23;17(1):71. Epub 2017 Jan 23.
    Department of Cosmeceutics, China Medical University, Taichung, 404, Taiwan.
    Background: The derivative of caffeamide exhibits antioxidant and antityrosinase activity. The activity and mechanism of N-(4-methoxyphenyl) caffeamide (K36E) on melanogenesis was investigated.

    Methods: B16F0 cells were treated with various concentrations of K36E; the melanin contents and related signal transduction were studied. Read More

    Synthesis, Characterization, and Evaluation of Thiazolidine Derivatives of Cysteine for Suppressing Eumelanin Production.
    Chem Pharm Bull (Tokyo) 2016 ;64(12):1681-1691
    Institute for Innovation, Ajinomoto Co., Inc.
    In the pathway of melanin biosynthesis, cysteine (Cys) is utilized for the synthesis of pheomelanin. Accordingly, Cys is considered to suppress the formation of brown-black eumelanin. Although attempts have been made to utilize Cys and its derivatives as skin-whitening agents, their instability and odor hinders their application as a cosmetic agent. Read More

    The depigmenting effect of natural resorcinol type polyphenols Kuwanon O and Sanggenon T from the roots of morus australis.
    J Ethnopharmacol 2017 Jan 13;195:196-203. Epub 2016 Nov 13.
    School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, PR China. Electronic address:
    Ethnopharmacological Relevance: Morus australis, one of the major Morus species growing in East Asia, is rich in phenolic compounds. The extract of M. australis has been used as skin whitening components for a long period. Read More

    Tyrosinase inhibition and antioxidant properties of Asphodelus microcarpus extracts.
    BMC Complement Altern Med 2016 Nov 9;16(1):453. Epub 2016 Nov 9.
    Department of Life and Environmental Sciences, University of Cagliari, SS 554, Bivio per Sestu, I-09042 Monserrato, Cagliari, Italy.
    Background: Asphodelus microcarpus belongs to the family Liliaceae that include several medicinal plants. In the traditional medicine plants of the genus Asphodelus are used to treat skin disorders such as ectodermal parasites, psoriasis, microbial infection and for lightening freckles. In order to find novel skin depigmenting agents, the present work was carry out to evaluate antioxidant activity and tyrosinase inhibitory potential of leaves, flowers and tubers extracts of A. Read More

    Jasmine rice panicle: A safe and efficient natural ingredient for skin aging treatments.
    J Ethnopharmacol 2016 Dec 6;193:607-616. Epub 2016 Oct 6.
    School of Cosmetic Science, Mae Fah Luang University, Chiang Rai, 57100 Thailand; Phytocosmetics and Cosmeceuticals Research Group, Mae Fah Luang University, Chiang Rai 57100, Thailand.
    Ethnopharmacological Relevance: While rice is one of the most important global staple food sources its extracts have found many uses as the bases of herbal remedies. Rice extracts contain high levels of phenolic compounds which are known to be bioactive, some of which show cutaneous benefits and activity towards skin disorders. This study highlights an assessment of the cellular activity and clinical efficacy of rice panicle extract, providing necessary information relevant to the development of new cosmetic products. Read More

    Optimization of extraction conditions for osthol, a melanogenesis inhibitor from Cnidium monnieri fruits.
    Pharm Biol 2016 Aug 4;54(8):1373-9. Epub 2016 May 4.
    a College of Pharmacy, Chungbuk National University , Cheongju , Korea ;
    Context: Coumarin derivatives have been reported to inhibit melanin biosynthesis.

    Objective: The melanogenesis inhibitory activity of osthol, a major coumarin of the fruits of Cnidium monnieri Cusson (Umbelliferae), and optimized extraction conditions for the maximum yield from the isolation of osthol from C. monnieri fruits were investigated. Read More

    Glutathione as a skin whitening agent: Facts, myths, evidence and controversies.
    Indian J Dermatol Venereol Leprol 2016 May-Jun;82(3):262-72
    Skinnocence: The Skin Clinic, Gurgaon, Haryana, India.
    Glutathione is a low molecular weight thiol-tripeptide that plays a prominent role in maintaining intracellular redox balance. In addition to its remarkable antioxidant properties, the discovery of its antimelanogenic properties has led to its promotion as a skin-lightening agent. It is widely used for this indication in some ethnic populations. Read More

    Functionality study of santalin as tyrosinase inhibitor: A potential depigmentation agent.
    Int J Biol Macromol 2016 May 30;86:383-9. Epub 2016 Jan 30.
    School of Bio Sciences and Technology, VIT University, Vellore 632014, Tamil Nadu, India. Electronic address:
    Excessive melanin production leads to hyperpigmentation disorders which results in distressing aesthetic values. Though there are some synthetic depigmentation agents available it has been reported to possess cytotoxic and mutagenic effects. Hence there is a need for the development of safe and non toxic natural tyrosinase inhibitors. Read More

    Antitumoral, antioxidant, and antimelanogenesis potencies of Hawthorn, a potential natural agent in the treatment of melanoma.
    Melanoma Res 2016 Jun;26(3):211-22
    aLaboratory of Cellular and Molecular Biology, Faculty of Dental Medicine bUnit of Natural and Bioactive Substances and Biotechnology, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia cLaboratory of Pharmacognosy, Faculty of Pharmacy, University of Lille 2, Lille, France.
    The lack of an efficient agent that does not have the disadvantage of low activity (kojic acid), high cytotoxicity, and mutagenicity (hydroquinone), poor skin penetration (arbutin), or low stability in formulation (glabridin) led us to continue our research on new antipigmentation/skin-lightening agents. Therefore, research of natural products that can modulate the metabolism of pigmentation is of great interest. Otherwise, malignant melanoma is one of the most aggressive forms of skin cancer, with high metastatic potential, and currently, there is no effective chemotherapy against invasive melanoma. Read More

    Systemic complications during voluntary cosmetic depigmentation among women in Togo: A case-control study.
    Ann Dermatol Venereol 2016 Mar 15;143(3):197-201. Epub 2016 Jan 15.
    Department of dermatology and venereology, University of Lomé, Sylvanus Olympio University Hospital, BP 81056, 1, rue de l'Hôpital, Lomé, Togo. Electronic address:
    Objective: The aim of our study was to document the systemic complications of skin bleaching among women in Togo.

    Methods: This was a case-control study conducted between December 2009 and December 2013. Cases comprised of women using skin-bleaching products for at least 6 months and age-matched with non-users (±3 years). Read More

    Microneedling in facial recalcitrant melasma: report of a series of 22 cases.
    An Bras Dermatol 2015 Nov-Dec;90(6):919-21
    Santa Casa de Misericórdia do Recife, Recife, PE, Brazil.
    Melasma is a chronic skin disorder that results in symmetrical, blotchy, brownish facial pigmentation. It is more common in women than in men, it generally starts between 20 and 40 years, and it can lead to considerable embarrassment and distress. The aims of this article is to evaluate the treatment with the microneedling method in 18 female and 4 male with recalcitrant melasma. Read More

    Preliminary study on the skin lightening practice and health symptoms among female students in Malaysia.
    J Environ Public Health 2015 26;2015:591790. Epub 2015 Nov 26.
    Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, Malaysia.
    Many cases of dermatologic complication were reported with the use of skin lightening products. This study assessed the skin lightening practice and health symptoms among female students. Self-administered questionnaire was distributed to 104 female students (56 undergraduates and 48 postgraduates) aged 24 ± 2 years in Universiti Putra Malaysia. Read More

    Regulatory effect of hydroquinone-tetraethylene glycol conjugates on zebrafish pigmentation.
    Bioorg Med Chem Lett 2016 Jan 26;26(2):699-705. Epub 2015 Sep 26.
    Graduate School of East-West Medical Science, Kyung Hee University, Gyeonggi-do 449-701, Republic of Korea. Electronic address:
    We synthesized two hydroquinone-tetraethylene glycol conjugates (HQ-TGs) and investigated their logP, photophysical stability, and redox chemical stability. HQ-TGs are a little more hydrophilic than hydroquinone (HQ) and show an enhanced photophysical and redox chemical stability compared with HQ. In addition we studied the effect of HQ-TGs on cell viability and on zebrafish pigmentation. Read More

    A novel cream formulation containing nicotinamide 4%, arbutin 3%, bisabolol 1%, and retinaldehyde 0.05% for treatment of epidermal melasma.
    Cutis 2015 Nov;96(5):337-42
    Dermatology Clinic, Santa Casa de São Paulo Hospital and Medical School, Brazil.
    Epidermal melasma is a common hyperpigmentation disorder that can be challenging to treat. Although current treatment options for melasma are limited, topical skin-lightening preparations have widely been used as alternatives to hydroquinone. In this prospective, single-arm, open-label study, treatment of epidermal melasma with a novel cream formulation containing nicotinamide 4%, arbutin 3%, bisabolol 1%, and retinaldehyde 0. Read More

    Opinion of the Scientific Committee on Consumer safety (SCCS)--Opinion on the safety of the use of α-arbutin in cosmetic products.
    Regul Toxicol Pharmacol 2016 Feb 2;74:75-6. Epub 2015 Dec 2.
    Leibniz Research Centre for Working Environment and Human Factors (IfADo), Dortmund, Germany.
    Conclusion Of The Opinion: The SCCS considers the use of α-Arbutin safe for consumers in cosmetic products in a concentration up to 2% in face creams and up to 0.5% in body lotions. A potential combined use of α-Arbutin and other hydroquinone releasing substances in cosmetic products has not been evaluated in this Opinion. Read More

    A Game-Theoretic Model of Marketing Skin Whiteners.
    Health Mark Q 2015 13;32(4):367-81. Epub 2015 Nov 13.
    a School of Business , Wilmington University , New Castle , DE.
    Empirical studies consistently find that people in less developed countries tend to regard light or "white" skin, particularly among women, as more desirable or superior. This is a study about the marketing of skin whiteners in these countries, where over 80 percent of users are typically women. It proceeds from the following premises: a) Purely market or policy-oriented approaches toward the risks and harms of skin whitening are cost-inefficient; b) Psychosocial and informational factors breed uninformed and risky consumer choices that favor toxic skin whiteners; and c) Proliferation of toxic whiteners in a competitive buyer's market raises critical supplier accountability issues. Read More

    Rhododenol-induced leukoderma in a mouse model mimicking Japanese skin.
    J Dermatol Sci 2016 Jan 27;81(1):35-43. Epub 2015 Oct 27.
    Department of Dermatology, Yamagata University Faculty of Medicine, Yamagata, Japan.
    Background: Rhododendrol, 4-(4-hydroxyphenyl)-2-butanol, Rhododenol(®) (RD), a naturally occurring phenolic compound, was developed as a tyrosinase inhibitor for skin-lightening/whitening cosmetics. In 2013, skin depigmentation was reported in consumers using RD-containing skin-brightening cosmetics; this condition is called RD-induced leukoderma.

    Objective: The etiology of RD-induced leukoderma is still largely unknown. Read More

    The globalization of whitening: prevalence of skin lighteners (or bleachers) use and its social correlates among university students in 26 countries.
    Int J Dermatol 2016 Feb 15;55(2):165-72. Epub 2015 Oct 15.
    Department of Sociology, Psychology and Social Work, The University of the West Indies, Mona, Jamaica.
    Background: The aim of this study was to investigate the use of skin lighteners and its social correlates in university students from 26 low, middle income, and emerging economy countries.

    Methods: Using anonymous questionnaires, data were collected from 19,624 undergraduate university students (mean age 20.8, SD 2. Read More

    HPLC-UV Method for the Identification and Screening of Hydroquinone, Ethers of Hydroquinone and Corticosteroids Possibly Used as Skin-Whitening Agents in Illicit Cosmetic Products.
    J Chromatogr Sci 2016 Mar 13;54(3):343-52. Epub 2015 Oct 13.
    Agence Nationale de Sécurité du Médicament et des Produits de Santé (ANSM), Direction des Contrôles (CTROL), 143/147 boulevard Anatole France, 93285 Saint-Denis Cedex, France.
    Corticosteroids, hydroquinone and its ethers are regulated in cosmetics by the Regulation 1223/2009. As corticosteroids are forbidden to be used in cosmetics and cannot be present as contaminants or impurities, an identification of one of these illicit compounds deliberately introduced in these types of cosmetics is enough for market survey control. In order to quickly identify skin-whitening agents present in illegal cosmetics, this article proposes an HPLC-UV method for the identification and screening of hydroquinone, 3 ethers of hydroquinone and 39 corticosteroids that may be found in skin-whitening products. Read More

    Inhibitory effects of pomegranate concentrated solution on the activities of hyaluronidase, tyrosinase, and metalloproteinase.
    J Cosmet Sci 2015 May-Jun;66(3):145-59
    Synopsis Botanical antioxidants have attracted much attention as useful preventatives of skin damage. Pomegranate is consumed throughout the world for its beneficial health effects, including its antioxidant and anti-inflammatory activities. We investigated whether pomegranate concentrated solution (PCS) could serve as a potential functional cosmetic ingredient that exerts a skin-whitening effect and antiwrinkle activity. Read More

    Antimelanogenic Effects of Picrionoside A Isolated from the Leaves of Korean Ginseng.
    Biol Pharm Bull 2015 ;38(10):1663-7
    Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA.
    This study was initiated to isolate active metabolites from the leaves of Panax ginseng. Among them, picrionoside A, a megastigmane glucoside, was isolated from the leaves of P. ginseng C. Read More

    Synthesis and Biological Evaluation of Resveratrol Derivatives as Melanogenesis Inhibitors.
    Molecules 2015 Sep 17;20(9):16933-45. Epub 2015 Sep 17.
    College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 28644, Korea.
    Resveratrol (1), a naturally occurring stilbene compound, has been suggested as a potential whitening agent with strong inhibitory activity on melanin synthesis. However, the use of resveratrol in cosmetics has been limited due to its chemical instability and poor bioavailability. Therefore, resveratrol derivatives were prepared to improve bioavailability and anti-melanogenesis activity. Read More

    Design, synthesis, and anti-melanogenic effects of (E)-2-benzoyl-3-(substituted phenyl)acrylonitriles.
    Drug Des Devel Ther 2015 4;9:4259-68. Epub 2015 Aug 4.
    College of Pharmacy, Pusan National University, Busan, Republic of Korea.
    Background: Tyrosinase is the most prominent target for inhibitors of hyperpigmentation because it plays a critical role in melaninogenesis. Although many tyrosinase inhibitors have been identified, from both natural and synthetic sources, there remains a considerable demand for novel tyrosinase inhibitors that are safer and more effective.

    Methods: (E)-2-Benzoyl-3-(substituted phenyl)acrylonitriles (BPA analogs) with a linear β-phenyl-α,β-unsaturated carbonyl scaffold were designed and synthesized as potential tyrosinase inhibitors. Read More

    4-n-butylresorcinol dissolving microneedle patch for skin depigmentation: a randomized, double-blind, placebo-controlled trial.
    J Cosmet Dermatol 2016 Mar 5;15(1):16-23. Epub 2015 Sep 5.
    Department of Biotechnology, Yonsei University, Seoul, Korea.
    Background: For effective skin depigmentation, the skin depigmentation agent must be delivered to melanocytes, where melanin is synthesized. Although dissolving microneedle (DMN) is one of the best transdermal drug delivery systems to deliver the active compound, no clinical trial has been conducted in terms of safety and efficacy.

    Objectives: To assess the clinical efficacy and safety of a DMN patch that contained 4-n-butylresorcinol, a skin depigmentation agent. Read More

    Design, synthesis and biological evaluation of hydroxy substituted amino chalcone compounds for antityrosinase activity in B16 cells.
    Bioorg Chem 2015 Oct 24;62:117-23. Epub 2015 Aug 24.
    School of Chemistry and Forensic Science, University of Technology Sydney, 15 Broadway, Ultimo, NSW 2007, Australia.
    A series of hydroxy substituted amino chalcone compounds have been synthesized. These compounds were then evaluated for their inhibitory activities on tyrosinase and melanogenesis in murine B16F10 melanoma cell lines. The structures of the compounds synthesized were confirmed by (1)H NMR, (13)C NMR, FTIR and HRMS. Read More

    [Undesirable pigmentation].
    Hautarzt 2015 Oct;66(10):757-63
    Klinik für Dermatologie und Allergologie, Hauttumorzentrum Wiesbaden, HSK, Dr. Horst Schmidt Kliniken, Helios Verbundklinik, Ludwig-Erhard-Straße 100, 65199, Wiesbaden, Deutschland.
    Background: Homogenous pigmentation can be induced by α-melanocyte-stimulating hormone (MSH) homologues. Cosmetically inacceptable pigmentation is mostly located on the face.

    Objectives: Although afamelatonide is a prescription drug for the orphan disease erthropoetic protoporphyria, structurally related α-MSH derivatives are available via the internet. Read More

    Effects of rhododendrol and its metabolic products on melanocytic cell growth.
    J Dermatol Sci 2015 Nov 26;80(2):142-9. Epub 2015 Jul 26.
    Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake 470-1192, Japan.
    Background: Rhododendrol (RD), a skin-whitening agent, is believed to be associated with cases of cosmetics-related leukoderma that have been reported in Japan. Recently, we have shown that RD is catalyzed by tyrosinase to produce putative toxic metabolites RD-catechol and RD-cyclic catechol.

    Objective: To examine the cytotoxicity and production of reactive oxygen species (ROS) in melanocytic cells by RD and its metabolic products. Read More

    Callicarpa longissima extract, carnosol-rich, potently inhibits melanogenesis in B16F10 melanoma cells.
    J Nat Med 2016 Jan 13;70(1):28-35. Epub 2015 Aug 13.
    Institute for Molecular Science of Medicine, Aichi Medical University, 1-1, Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
    Cosmetic industries focus on developing materials and resources that regulate skin pigmentation. Melanin, the major pigment in human skin, protects the skin against damage from ultraviolet light. An ethanolic extract of the leaves of Callicarpa longissima inhibits melanin production in B16F10 mouse melanoma cells by suppressing microphthalmia-associated transcription factor (MITF) gene expression. Read More

    Falsely elevated capillary glucose and ketone levels and use of skin lightening creams.
    BMJ 2015 Jul 29;351:h3879. Epub 2015 Jul 29.
    Department of Diabetes and Endocrinology, Assistance Publique - Hôpitaux de Paris, DHU FIRE, Lariboisière Hospital University Paris-Diderot Paris-7, 75010 Paris, France, and INSERM UMRS 1138, Cordeliers Research Centre, 75006, Paris, France

    Combinations of potent topical steroids, mercury and hydroquinone are common in internationally manufactured skin-lightening products: a spectroscopic study.
    Clin Exp Dermatol 2016 Mar 26;41(2):196-201. Epub 2015 Jul 26.
    Division of Dermatology, Groote Schuur Hospital, Cape Town, South Africa.
    Background: The topical steroids betamethasone (BM) and clobetasol propionate (CP) are illegal in cosmetics. Hydroquinone (HQ) and mercury (Hg) are either illegal or allowed only in limited concentrations (2% and 1 ppm, respectively).

    Aim: To investigate active ingredients and countries of origin of popular skin-lightening products available in Cape Town, South Africa. Read More

    Skin lightening practices: an epidemiological study of South African women of African and Indian ancestries.
    Br J Dermatol 2015 Jul;173 Suppl 2:2-9
    Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Congella 4013, Durban, South Africa.
    Background: Cutaneous adverse sequelae of skin lightening creams present with myriad skin complications and affect dermatology practice, particularly in sub-Saharan Africa where such products are widely used, with a prevalence of 25-67%.

    Objectives: To examine the skin lightening practices of both African and Indian women living in South Africa.

    Methods: A cross-sectional survey was undertaken in the general outpatient departments of two regional university hospitals in Durban, South Africa. Read More

    Development of Tyrosinase Promoter-Based Fluorescent Assay for Screening of Anti-melanogenic Agents.
    Biol Pharm Bull 2015 15;38(10):1542-7. Epub 2015 Jul 15.
    Biospectrum Life Science Institute.
    For screening of skin-whitening ingredients that modulate inhibition of melanogenesis, tyrosinase promoter-based assay using a three-dimensional (3D) spheroid culture technique is a beneficial tool to improve the accuracy of raw material screening in cosmetics through mimicking of the in vivo microenvironment. Although the advantages of high-throughput screening (HTS) are widely known, there has been little focus on specific cell-based promoter assays for HTS in identifying skin-whitening ingredients that inhibit accumulation of melanin. The aim of this study was therefore to develop a large-scale compatible assay through pTyr-EGFP, an enhanced green fluorescent protein (EGFP)-based tyrosinase-specific promoter, to seek potential melanogenesis inhibitors for cosmetic use. Read More

    Tyrosinase-Catalyzed Hydroxylation of 4-Hexylresorcinol, an Antibrowning and Depigmenting Agent: A Kinetic Study.
    J Agric Food Chem 2015 Aug 29;63(31):7032-40. Epub 2015 Jul 29.
    †GENZ-Group of Research on Enzymology, Department of Biochemistry and Molecular Biology-A, ‡Group of Synthetic Organic Chemistry, Department of Organic Chemistry, and #Department of Analytical Chemistry, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, 30071 Murcia, Spain.
    4-Hexylresorcinol (HR) is a compound used in the food and cosmetic industries as an antibrowning and lightening agent. Its use is mainly attributed to its inhibitory effect on the enzyme tyrosinase. However, the enzyme hydroxylates HR to an o-diphenol, which it then oxidizes to an o-quinone, which rapidly isomerizes to p-quinone. Read More

    An open-label, single-arm trial of the safety and efficacy of a novel preparation of glutathione as a skin-lightening agent in Filipino women.
    Int J Dermatol 2016 Feb 3;55(2):153-7. Epub 2015 Jul 3.
    Department of Dermatology, St Luke's Medical Center, Bonifacio Global City, Metro Manila, Philippines.
    Background: Glutathione (GSH) is a naturally occurring thiol that has been reported to cause skin lightening in a manner for which several mechanisms have been proposed. Highest plasma concentrations are achieved with IV administration but are accompanied by greater levels of risk. Oral administration has been less successful in elevating plasma GSH levels. Read More

    [Skin lightening products are a part of everyday life in many parts of the world. Corticosteroids, hydroquinone and mercury are common ingredients].
    Lakartidningen 2015 Jun 30;112. Epub 2015 Jun 30.
    Karolinska University Hospital - Department of Endokrinology Stockholm, Sweden - , Sweden.
    During the past decade, attention has been drawn towards the globally increased usage of skin-lightening (bleaching) products which are manufactured and sold, particularly in Africa and Asia, but also via the internet and in local shops all over North America and Europe. The active ingredients include hydroquinone, mercury and potent corticosteroids which can have severe health effects.  After investigating a patient at our clinic where the symptoms and findings could be linked to the use of bleaching products, we started to search the literature for similar cases. Read More

    A double-blind, placebo-controlled randomized trial of Serratulae quinquefoliae folium, a new source of β-arbutin, in selected skin hyperpigmentations.
    J Cosmet Dermatol 2015 Sep 28;14(3):185-90. Epub 2015 Jun 28.
    Department of Medicinal and Cosmetic Natural Products, Poznan University of Medical Sciences, Poznan, Poland.
    Background: Arbutin is one of the most effective lightening substances. Serratula quinquefolia is a new source of its β-anomer. The HPLC method showed that the solid content of this compound in the dried plant raw material accounts for 6. Read More

    N-Nicotinoyl tyramine, a novel niacinamide derivative, inhibits melanogenesis by suppressing MITF gene expression.
    Eur J Pharmacol 2015 Oct 25;764:1-8. Epub 2015 Jun 25.
    Department of Food Science and Technology, Jungwon University, 85, Munmu-ro, Geosan-eup, Geosan-gun, Chungbuk 367-805, Republic of Korea. Electronic address:
    We synthesized and investigated the inhibitory effects of a novel niacinamide derivative, N-nicotinoyltyramine (NNT) on melanogenesis. NNT inhibited melanin production in B16F10 murine melanoma cells stimulated with α-melanocyte stimulating hormone (α-MSH), in human melanocyte and in three-dimensional cultured human skin model. NNT did not affect the catalytic activity of tyrosinase, but acted as an inhibitor of microphthalmia-associated transcription factor (MITF) and tyrosinase expressions in B16F10 cells. Read More

    Depigmentation and hypertrophic scars after application of a fluid lactic acid tattoo eraser.
    Wien Med Wochenschr 2015 May 12;165(9-10):195-8. Epub 2015 May 12.
    Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Friedrichstrasse 41, 01067, Dresden, Germany,
    Background: Tattoo removal is often requested by patients. The gold standard is laser tattoo removal that can be time- and cost-intensive. Therefore, safe alternatives without lasers, pain, and scars would be desirable. Read More

    [Ocular lesions of artificial depigmentation].
    J Fr Ophtalmol 2015 Jun 6;38(6):493-6. Epub 2015 May 6.
    Clinique ophtalmologique EPS Aristide Le Dantec de Dakar, Dakar, Sénégal.
    Purpose: To evaluate the type and frequency of the ocular lesions found in patients practicing artificial depigmentation.

    Patients And Method: We conducted a prospective study over 3 months involving 108 patients, of whom 72 underwent depigmentation, and 36 did not, representing the controls.

    Results: Among patients undergoing depigmentation, 100% were female, of whom 34. Read More

    Effect of the combination of different depigmenting agents in vitro.
    J Cosmet Sci 2014 Nov-Dec;65(6):365-75
    Melanin plays a key role in our skin, protecting us against ultraviolet radiation, but there are situations in which its anomalous accumulation can lead to either aesthetic problems or diseases like melasma. For this reason, it is important to find agents that are able to decrease the skin pigmentation. It has been demonstrated that the melanin synthesis pathway can be inhibited at different levels by different mechanisms of action. Read More


    Clinical and instrumental evaluation of the efficacy of a new depigmenting agent containing a combination of a retinoid, a phenolic agent and an antioxidant for the treatment of solar lentigines.
    Dermatology 2015 9;230(4):360-6. Epub 2015 Apr 9.
    Department of Dermatology, San Gallicano Institute IRCCS, Rome, Italy.
    Background: Solar lentigines are common benign macular hyperpigmented lesions localized on sun-exposed areas.

    Objective: To evaluate the efficacy and safety of a new depigmenting agent containing a retinoid (retinaldehyde), a new phenolic agent (4-(1-phenylethyl)-resorcinol) and a reducing agent (δ-tocopheryl-β-D-glucopyranoside) in the topical treatment of solar lentigines.

    Patients And Methods: Twenty patients with solar lentigines of the face and hands applied the depigmenting agent on each lentigo once daily for 12 weeks. Read More

    Quantitative Determination of α-Arbutin, β-Arbutin, Kojic Acid, Nicotinamide, Hydroquinone, Resorcinol, 4-Methoxyphenol, 4-Ethoxyphenol, and Ascorbic Acid from Skin Whitening Products by HPLC-UV.
    J AOAC Int 2015 Jan-Feb;98(1):5-12
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
    An HPLC-UV method was developed for the quantitative analysis of nine skin whitening agents in a single injection. These compounds are α-arbutin, β-arbutin, kojic acid, nicotinamide, resorcinol, ascorbic acid, hydroquinone, 4-methoxyphenol, and 4-ethoxyphenol. The separation was achieved on a reversed-phase C18 column within 30 min. Read More

    1 OF 5