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    271 results match your criteria Skin Lightening and Depigmenting Agents

    1 OF 6

    Natural options for management of melasma, a review.
    J Cosmet Laser Ther 2018 Feb 20:1-12. Epub 2018 Feb 20.
    a Laser Research Centre, Faculty of Health Sciences , University of Johannesburg , Doornfontein , South Africa.
    A blemish free, even-toned skin is universally associated with healthy skin. This reasoning makes people desire to have a flawless skin. Melanin is a naturally occurring pigment in humans. Read More

    Postinflammatory hyperpigmentation: A comprehensive overview: Treatment options and prevention.
    J Am Acad Dermatol 2017 Oct;77(4):607-621
    Department of Dermatology, Henry Ford Hospital, Detroit, Michigan. Electronic address:
    Postinflammatory hyperpigmentation (PIH) occurs after various dermatoses, exogenous stimuli, and dermatologic procedures. The clinical course of PIH is chronic and unpredictable, although the probability of resolution of epidermal hyperpigmentation is better than those of dermal hyperpigmentation. PIH can be prevented or alleviated. Read More

    [High school student and skin bleaching in Cameroon].
    Sante Publique 2017 Apr;29(2):263-270
    Introduction: Skin bleaching is a common practice in Africa, particularly in Cameroon. Studies show that it represents a danger for health, in terms of a demonstrated increased risk of dermatological diseases. However, increasing numbers of people are using skin bleaching in African cities, despite the fact that they are sometimes aware of the risk. Read More

    Ethyl acetate extract from Panax ginseng C.A. Meyer and its main constituents inhibit α-melanocyte-stimulating hormone-induced melanogenesis by suppressing oxidative stress in B16 mouse melanoma cells.
    J Ethnopharmacol 2017 Aug 8;208:149-156. Epub 2017 Jul 8.
    Jilin Technology Innovation Center for Chinese Medicine Biotechnology, College of Biology and Chemistry, Beihua University, Jilin City, Jilin Province 132013, China. Electronic address:
    Ethnopharmacological Relevance: Hyperpigmentation disease involves darkening of the skin color due to melanin overproduction. Panax ginseng C.A. Read More

    Inhibitory effect of 5-iodotubercidin on pigmentation.
    Biochem Biophys Res Commun 2017 09 4;490(4):1282-1286. Epub 2017 Jul 4.
    Department of Dermatology and Institute of Health Sciences, School of Medicine, Gyeongsang National University & Hospital, Jinju, Republic of Korea. Electronic address:
    Melanin pigments are the primary contributors for the skin color. They are produced in melanocytes and then transferred to keratinocytes, eventually giving various colors on skin surface. Although many depigmenting and/or skin-lightening agents have been developed, there is still a growing demand on materials for reducing pigmentation. Read More

    Synthesis and biological evaluation of caffeic acid derivatives as potent inhibitors of α-MSH-stimulated melanogenesis.
    Bioorg Med Chem Lett 2017 08 3;27(15):3374-3377. Epub 2017 Jun 3.
    College of Pharmacy and Medicinal Research Center (MRC), Chungbuk National University, Cheongju 28160, Republic of Korea. Electronic address:
    We have disclosed our effort to develop caffeic acid derivatives as potent and non-toxic inhibitors of α-MSH-stimulated melanogenesis to treat pigmentation disorders and skin medication including a cosmetic skin-whitening agent. The SAR studies revealed that cyclohexyl ester and secondary amide derivatives of caffeic acid showed significant inhibitory activities. Read More

    Improvement of skin whitening agents efficiency through encapsulation: Current state of knowledge.
    Int J Pharm 2017 Jun 14;526(1-2):50-68. Epub 2017 Apr 14.
    Faculty of Sciences, Bioactive Molecules Research Laboratory, Lebanese University, Lebanon. Electronic address:
    Hyperpigmentation is one of the most common skin disorder that affects both men and women of all ethnic groups, caused by several factors, such as UV exposure and skin inflammation. Topical whitening agents were found to be the best and the least aggressive therapy for treating hyperpigmentation compared to instrumental approaches. However, topical treatment faces several obstacles due to the low stability of the whitening agents. Read More

    Depigmentation Therapies for Vitiligo.
    Dermatol Clin 2017 Apr;35(2):219-227
    Vitiligo & Pigmentation Institute of Southern California, 5670 Wilshire Boulevard #650, Los Angeles, CA 90036, USA.
    The general goals of medical management of vitiligo are to repigment vitiliginous areas of skin and to stabilize the progression of depigmentation. However, for some patients with vitiligo affecting extensive body surface areas who are unresponsive to repigmentation therapies, depigmentation of the remaining normal skin may be a better choice. Candidates for depigmentation therapy should be carefully screened and patient education is essential. Read More

    Chemical-Induced Vitiligo.
    Dermatol Clin 2017 Apr;35(2):151-161
    Department of Dermatology, University of Massachusetts Medical School, 364 Plantation Street, LRB 225, Worcester, MA 01605, USA. Electronic address:
    Chemical-induced depigmentation of the skin has been recognized for more than 75 years, first as an occupational hazard but then extending to those using household commercial products as common as hair dyes. Since their discovery, these chemicals have been used therapeutically in patients with severe vitiligo to depigment their remaining skin and improve their appearance. Because chemical-induced depigmentation is clinically and histologically indistinguishable from nonchemically induced vitiligo, and because these chemicals appear to induce melanocyte autoimmunity, this phenomenon should be known as "chemical-induced vitiligo," rather than less accurate terms that have been previously used. Read More

    Curcuma aeruginosa Roxb. essential oil slows hair-growth and lightens skin in axillae; a randomised, double blinded trial.
    Phytomedicine 2017 Feb 20;25:29-38. Epub 2016 Dec 20.
    Bioscreening Unit, Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, Thailand. Electronic address:
    Background: Androgenic hair-growth contributes to secondary gender characteristics but can be troublesome in women. Inhibiting axillary hair-growth via 5-α-reductases using the Thai medicinal plant, Curcuma aeruginosa Roxb. is an attractive treatment strategy. Read More

    A New Depigmenting-Antifungal Methylated Grindelane from Grindelia chiloensis.
    Chem Biodivers 2017 May 5;14(5). Epub 2017 Apr 5.
    Instituto de Química Orgánica, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, Ayacucho, 471, 4000, Tucumán, Argentina.
    The new methylated grindelane diterpenoid, 7β-hydroxy-8(17)-dehydrogrindelic acid (1b), together with the known 7α-hydroxy-8(17)-dehydrogrindelic acid (2a), 6-oxogrindelic acid (3a), 4β-hydroxy-6-oxo-19-norgrindelic (4a), 19-hydroxygrindelic acid (5a), 18-hydroxygrindelic acid (6a), 4α-carboxygrindelic acid (7a), 17-hydroxygrindelic acid (8a), 6α-hydroxygrindelic acid (9a), 8,17-bisnor-8-oxagrindelic acid (10a), 7α,8α-epoxygrindelic acid (11a), and strictanonic acid (12a) as methyl esters were obtained from an Argentine collection of Grindelia chiloensis (Cornel.) Cabrera. Their structures and relative configurations were established on the basis of spectroscopic analysis. Read More

    N-(4-methoxyphenyl) caffeamide-induced melanogenesis inhibition mechanisms.
    BMC Complement Altern Med 2017 Jan 23;17(1):71. Epub 2017 Jan 23.
    Department of Cosmeceutics, China Medical University, Taichung, 404, Taiwan.
    Background: The derivative of caffeamide exhibits antioxidant and antityrosinase activity. The activity and mechanism of N-(4-methoxyphenyl) caffeamide (K36E) on melanogenesis was investigated.

    Methods: B16F0 cells were treated with various concentrations of K36E; the melanin contents and related signal transduction were studied. Read More

    Clinicopathological features, diagnosis, and treatment of IgA nephropathy with minimal change disease related to exposure to mercury-containing cosmetics: a case report
    Clin Nephrol 2017 Apr;87 (2017)(4):196-201
    Aim: Membranous nephropathy and minimal change disease (MCD) have been involved in mercury-induced nephrotic syndrome. IgA nephropathy is not known to be a common pathological type. In the present article, we report a case of IgA nephropathy with MCD following exposure to mercury-containing skin lightening cream. Read More

    Skin whitening agents: medicinal chemistry perspective of tyrosinase inhibitors.
    J Enzyme Inhib Med Chem 2017 Dec;32(1):403-425
    a PharmaCenter Bonn , Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn , Bonn , Germany.
    Melanogenesis is a process to synthesize melanin, which is a primary responsible for the pigmentation of human skin, eye and hair. Although numerous enzymatic catalyzed and chemical reactions are involved in melanogenesis process, the enzymes such as tyrosinase and tyrosinase-related protein-1 (TRP-1) and TRP-2 played a major role in melanin synthesis. Specifically, tyrosinase is a key enzyme, which catalyzes a rate-limiting step of the melanin synthesis, and the downregulation of tyrosinase is the most prominent approach for the development of melanogenesis inhibitors. Read More

    Split-Face Comparison of an Advanced Non-Hydroquinone Lightening Solution to 4% Hydroquinone.
    J Drugs Dermatol 2016 Dec;15(12):1571-1577
    Introduction: Hyperpigmentation is a primary concern for many cosmetic patients because of its high rate of occurrence and significant impact on perceived age. While 4% hydroquinone has been the gold-standard of treatment, there is a growing interest in non-hydroquinone solutions, however, many of these newer solutions fail to deliver equivalent improvement.

    Methods: This double-blind, randomized, split-face study compares the effects of a new OTC non-hydroquinone lightening product (JM) to an available 4% hydroquinone lightening solution (OB) on the appearance of hyperpigmentation, texture, and ne lines and wrinkles. Read More

    Development and Clinical Assessment of a Comprehensive Product for Pigmentation Control in Multiple Ethnic Populations.
    J Drugs Dermatol 2016 Dec;15(12):1562-1570
    Background: Pigmentary changes in people of different ethnic origins are controlled by slight variations in key biological pathways leading to different outcomes from the same treatment. It is important to develop and test products for desired outcomes in varying ethnic populations.

    Objectives: To develop a comprehensive product (LYT2) that affects all major biological pathways controlling pigmentation and test for clinical efficacy and safety in different ethnic populations. Read More

    Knowledge about, attitude toward, and practice of skin lightening products use and its social correlates among university students in five Association of Southeast Asian Nations (ASEAN) countries.
    Int J Dermatol 2017 Mar 17;56(3):277-283. Epub 2017 Jan 17.
    ASEAN Institute for Health Development, Mahidol University, Salaya, Phutthamonthon, Nakhonpathom, Thailand.
    Background: The aim of this study was to investigate the knowledge about, attitude toward, and use of skin lightening products (SLP) and its social and psychological correlates among university students from five Association of Southeast Asian Nations (ASEAN) countries.

    Methods: In a cross sectional survey, 3259 undergraduate university students (Mean age = 20.5 years, SD = 1. Read More

    Peroxisome proliferator-activated receptor α (PPARα) contributes to control of melanogenesis in B16 F10 melanoma cells.
    Arch Dermatol Res 2017 Apr 13;309(3):141-157. Epub 2017 Jan 13.
    Department of Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, ul. Gronostajowa 7, 30-387, Kraków, Poland.
    Recent studies revealed the cooperation between peroxisome proliferator-activated receptor gamma (PPARγ) and α-MSH signaling, which results in enhanced melanogenesis in melanocytes and melanoma cells. However, the agonists of PPARα, such as fenofibrate, exert depigmenting effect. Therefore, we aimed to check how the PPARα expression level affects the antimelanogenic activity of fenofibrate and whether PPARα modulates melanogenesis independently of its agonist. Read More

    In vitro Dermal Absorption of Hydroquinone: Protocol Validation and Applicability on Illegal Skin-Whitening Cosmetics.
    Skin Pharmacol Physiol 2016 5;29(6):300-308. Epub 2017 Jan 5.
    Division of Food, Medicines and Consumer Safety, Section Medicinal Products, Scientific Institute of Public Health (IPH), Brussels, Belgium.
    In Europe, hydroquinone is a forbidden cosmetic ingredient. It is, however, still abundantly used because of its effective skin-whitening properties. The question arises as to whether the quantities of hydroquinone used become systemically available and may cause damage to human health. Read More

    Alisol B, a triterpene from Alismatis rhizoma (dried rhizome of Alisma orientale), inhibits melanin production in murine B16 melanoma cells.
    Biosci Biotechnol Biochem 2017 Mar 4;81(3):534-540. Epub 2017 Jan 4.
    b Department of Biological Science and Technology , Tokushima University Graduate School , Tokushima , Japan.
    To develop new whitening agents from natural products, we screened 80 compounds derived from crude drugs in Kampo medicine in a melanin synthesis inhibition assay using murine B16 melanoma cells. The screen revealed that treatment with alisol B, a triterpene from Alismatis rhizoma, significantly decreased both melanin content and cellular tyrosinase activity in B16 cells. However, alisol B did not directly inhibit mushroom tyrosinase activity in vitro. Read More

    Use of skin-lightening products among selected urban communities in Accra, Ghana.
    Int J Dermatol 2017 Jan;56(1):32-39
    Department of Pathology, University of Ghana School of Biomedical and Allied Health Sciences, Accra, Ghana.
    Background: The practice of skin lightening has been reported from North America, Europe, Asia, and Africa. In literature, some prevalence rates exceed 50%, and both sexes are involved. Common agents used include hydroquinone, mercury, corticosteroids, and caustic agents. Read More

    Synthesis, Characterization, and Evaluation of Thiazolidine Derivatives of Cysteine for Suppressing Eumelanin Production.
    Chem Pharm Bull (Tokyo) 2016 ;64(12):1681-1691
    Institute for Innovation, Ajinomoto Co., Inc.
    In the pathway of melanin biosynthesis, cysteine (Cys) is utilized for the synthesis of pheomelanin. Accordingly, Cys is considered to suppress the formation of brown-black eumelanin. Although attempts have been made to utilize Cys and its derivatives as skin-whitening agents, their instability and odor hinders their application as a cosmetic agent. Read More

    The depigmenting effect of natural resorcinol type polyphenols Kuwanon O and Sanggenon T from the roots of morus australis.
    J Ethnopharmacol 2017 Jan 13;195:196-203. Epub 2016 Nov 13.
    School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, PR China. Electronic address:
    Ethnopharmacological Relevance: Morus australis, one of the major Morus species growing in East Asia, is rich in phenolic compounds. The extract of M. australis has been used as skin whitening components for a long period. Read More

    Tyrosinase inhibition and antioxidant properties of Asphodelus microcarpus extracts.
    BMC Complement Altern Med 2016 Nov 9;16(1):453. Epub 2016 Nov 9.
    Department of Life and Environmental Sciences, University of Cagliari, SS 554, Bivio per Sestu, I-09042 Monserrato, Cagliari, Italy.
    Background: Asphodelus microcarpus belongs to the family Liliaceae that include several medicinal plants. In the traditional medicine plants of the genus Asphodelus are used to treat skin disorders such as ectodermal parasites, psoriasis, microbial infection and for lightening freckles. In order to find novel skin depigmenting agents, the present work was carry out to evaluate antioxidant activity and tyrosinase inhibitory potential of leaves, flowers and tubers extracts of A. Read More

    [Cutaneous depigmentation in black female population for cosmetic purposes: results of a KAP survey conducted in Abidjan (Ivory Coast)].
    Pan Afr Med J 2016 23;24:159. Epub 2016 Jun 23.
    Centre de Dermatologie du CHU de Treichville d'Abidjan, Côte d'Ivoire.
    Introduction: Cutaneous depigmentation for cosmeticis purposes is a widespread practice among black African women. It has many complications that have been well documented for decades. However, the reasons of practitioners are not well known. Read More

    Risk assessment of skin lightening cosmetics containing hydroquinone.
    Regul Toxicol Pharmacol 2016 Nov 10;81:128-135. Epub 2016 Aug 10.
    Department of Epidemiology and Environmental Health, Juntendo University, Faculty of Medicine, Tokyo, Japan.
    Following reports on potential risks of hydroquinone (HQ), HQ for skin lightening has been banned or restricted in Europe and the US. In contrast, HQ is not listed as a prohibited or limited ingredient for cosmetic use in Japan, and many HQ cosmetics are sold without restriction. To assess the risk of systemic effects of HQ, we examined the rat skin permeation rates of four HQ (0. Read More

    Deoxyarbutin Possesses a Potent Skin-Lightening Capacity with No Discernible Cytotoxicity against Melanosomes.
    PLoS One 2016 24;11(10):e0165338. Epub 2016 Oct 24.
    Department of Dermatology, Renmin Hospital of Wuhan University, Wuhan, China.
    Safe and effective ingredients capable of removing undesired hyperpigmentation from facial skin are urgently needed for both pharmaceutical and cosmetic purposes. Deoxyarbutin (4-[(tetrahydro-2H-pyran-2-yl) oxy] phenol, D-Arb) is a glucoside derivative of hydroquinone. Here, we investigated the toxicity and efficacy of D-Arb at the sub-cellular level (directly on melanosomes) and skin pigmentation using in vivo and in vitro models to compare with its parent compound hydroquinone (1,4-benzenediol, HQ). Read More

    Jasmine rice panicle: A safe and efficient natural ingredient for skin aging treatments.
    J Ethnopharmacol 2016 Dec 6;193:607-616. Epub 2016 Oct 6.
    School of Cosmetic Science, Mae Fah Luang University, Chiang Rai, 57100 Thailand; Phytocosmetics and Cosmeceuticals Research Group, Mae Fah Luang University, Chiang Rai 57100, Thailand.
    Ethnopharmacological Relevance: While rice is one of the most important global staple food sources its extracts have found many uses as the bases of herbal remedies. Rice extracts contain high levels of phenolic compounds which are known to be bioactive, some of which show cutaneous benefits and activity towards skin disorders. This study highlights an assessment of the cellular activity and clinical efficacy of rice panicle extract, providing necessary information relevant to the development of new cosmetic products. Read More

    Novel Anti-Melanogenesis Properties of Polydeoxyribonucleotide, a Popular Wound Healing Booster.
    Int J Mol Sci 2016 Sep 1;17(9). Epub 2016 Sep 1.
    Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
    Polydeoxyribonucleotide (PDRN), a deoxyribonucleotide polymer, is popularly used for faster healing of cutaneous wounds and boosting of neocollagenesis of photoaged skin among current dermatologic practitioners. Some patients receiving PDRN injection treatment also reported improvement of photoaging-associated mottled pigmentation (PMP). To investigate the effect of PDRN on cutaneous melanogenesis, we examined the effect of PDRN and an available product (Placentex(®)) containing PDRN on melanogenesis using human melanocytes-keratinocytes cocultures and mouse melanocytes. Read More

    The Methoxyflavonoid Isosakuranetin Suppresses UV-B-Induced Matrix Metalloproteinase-1 Expression and Collagen Degradation Relevant for Skin Photoaging.
    Int J Mol Sci 2016 Sep 1;17(9). Epub 2016 Sep 1.
    Graduate School of Biotechnology, Kyung Hee University, Yongin 17104, Korea.
    Solar ultraviolet (UV) radiation is a main extrinsic factor for skin aging. Chronic exposure of the skin to UV radiation causes the induction of matrix metalloproteinases (MMPs), such as MMP-1, and consequently results in alterations of the extracellular matrix (ECM) and skin photoaging. Flavonoids are considered as potent anti-photoaging agents due to their UV-absorbing and antioxidant properties and inhibitory activity against UV-mediated MMP induction. Read More

    Fifty years of research and development of cosmeceuticals: a contemporary review.
    J Cosmet Dermatol 2016 Dec 6;15(4):527-539. Epub 2016 Aug 6.
    Department of Dermatology, Frimley Park Hospital NHS Foundation Trust, Frimley, UK.
    Facial rejuvenation can be categorized into skincare and facial contouring. Research and development of cosmeceuticals is aimed at addressing the major signs of photoaging: wrinkles, dyschromia, and sallowness. Assessment of photoaging comes in clinical and photographic forms; a photonumeric scale developed by Griffiths et al. Read More

    Simultaneous determination of four fluorescent whitening agents (including trans and cis isomers) in facial mask by dispersive solid-phase extraction combined with ultra high performance liquid chromatography and diode array detection.
    J Sep Sci 2016 Oct 30;39(19):3683-3689. Epub 2016 Aug 30.
    Guangdong Huaxin Products Testing and Inspection Technology Co. Ltd, Guangzhou, China.
    A novel ultra high performance liquid chromatography with diode array detection method, based on the dispersive solid-phase extraction by using polymer weak anion exchange as the sorbent, was established for the simultaneous determination of fluorescent whitening agents 85, 28, 351, and 71 in facial mask. The amounts of polymer weak anion exchange, adsorption time, and volume of elution solvent in the dispersive solid-phase extraction technology were optimized, and the developed method was validated in terms of the method limit of detection, method limit of quantitation, linear range, recovery, accuracy, and precision. Results indicated that the standard curves were linear over the selected concentration ranges of 0. Read More

    Mercury, hydroquinone and clobetasol propionate in skin lightening products in West Africa and Canada.
    Environ Res 2016 10 1;150:403-10. Epub 2016 Jul 1.
    Département de sciences biologiques, Université de Montréal, Montréal, QC, Canada H2V 2S9. Electronic address:
    Skin lightening products are types of cosmetics (creams, gels, lotions and soaps) applied voluntarily on skin. Several of these products contain a variety of active ingredients that are highly toxic. Among those toxic agents, the present study focuses on mercury, hydroquinone, and clobetasol propionate. Read More

    Antimelanogenesis Activity of Hydrolyzed Ginseng Extract (GINST) via Inhibition of JNK Mitogen-activated Protein Kinase in B16F10 Cells.
    J Food Sci 2016 Aug 29;81(8):H2085-92. Epub 2016 Jun 29.
    Ilhwa Co., BioTech Research Inst., Foreign Business Center, 25, Angol-ro 56 beon-gil, Guri-si, Gyeonggi-do, Korea.
    GINST is a hydrolyzed ginseng extract produced by an in vitro process that imitates the metabolic function of bacteria in the human digestive track and has approved by the Ministry of Food and Drug Safety of Korea for the management of postprandial hyperglycemia. Additionally, GINST has been reported to have other physiological functions including anti-aging and antioxidant effects. The objectives of this study are to compare the antimelanogenic effects of fresh ginseng extract (FGE) and GINST extract and to elucidate the functional mechanism. Read More

    The assessment of the effect of a cosmetic product brightening the skin of people with discolorations of different etiology.
    J Cosmet Dermatol 2016 Dec 28;15(4):493-502. Epub 2016 Jun 28.
    Department of Cosmetic Raw Materials Chemistry, Faculty of Pharmacy, Medical University of Lodz, Lodz, Poland.
    Background: Hyperpigmentations are disorders displayed with a change in the color of the skin, its strange shape, the lack of symmetry, and irregular placement. They appear no matter on the age, gender, and often as a congenital defect. Disorder connected with overproduction of melanin by pigmentary cells. Read More

    4-n-butylresorcinol, a depigmenting agent used in cosmetics, reacts with tyrosinase.
    IUBMB Life 2016 08 24;68(8):663-72. Epub 2016 Jun 24.
    Department of Biochemistry and Molecular Biology-A, GENZ-Group of Research on Enzymology (, Regional Campus of International Excellence "Campus Mare Nostrum,", University of Murcia, Espinardo, Murcia, Spain.
    4-n-Butylresorcinol (BR) is considered the most potent inhibitor of tyrosinase, which is why it is used in cosmetics as a depigmenting agent. However, this work demonstrates that BR is a substrate of this enzyme. The Em (met-tyrosinase) form is not active on BR, but Eox (oxy-tyrosinase) can act on this molecule, hydroxylating it to o-diphenol. Read More

    A Prospective Trial Comparing Q-Switched Ruby Laser and a Triple Combination Skin-Lightening Cream in the Treatment of Solar Lentigines.
    Dermatol Surg 2016 Jul;42(7):853-7
    Department of Dermatology, University Hospital, Zurich, Switzerland.
    Background: Quality-switched (QS) laser therapy is a safe and well-established treatment option for removing solar lentigines. Triple combination therapy (TCT) with the active pharmaceutical ingredients hydroquinone 5%, tretinoin 0.03%, and dexamethasone 0. Read More

    Skin Pretreatment With Conventional Non-Fractional Ablative Lasers Promote the Transdermal Delivery of Tranexamic Acid.
    Dermatol Surg 2016 Jul;42(7):867-74
    *Department of Nutrition and Health Sciences, Chang Gung University of Science and Technology, Taoyuan, Taiwan; †Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan; ‡Department of Anatomy, College of Medicine, Chang Gung University, Taoyuan, Taiwan; §Department of Cosmetic Science, Chang Gung University of Science and Technology, Taoyuan, Taiwan; ‖College of Medicine, Chang Gung University, Taoyuan, Taiwan; ¶Department of Dermatology, Aesthetic Medical Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
    Background: Laser pretreatment of skin can be used to enable drugs used in dermatology to penetrate the skin to the depth necessary for their effect to take place.

    Objective: To compare the permeation of tranexamic acid after conventional non-fractionated ablative Er:YAG and CO2 laser pretreatment in a laser-aided transdermal delivery system.

    Materials And Methods: An erbium-doped yttrium aluminium garnet (Er:YAG) and a CO2 laser were used to pretreat dorsal porcine skin. Read More

    Optimization of extraction conditions for osthol, a melanogenesis inhibitor from Cnidium monnieri fruits.
    Pharm Biol 2016 Aug 4;54(8):1373-9. Epub 2016 May 4.
    a College of Pharmacy, Chungbuk National University , Cheongju , Korea ;
    Context: Coumarin derivatives have been reported to inhibit melanin biosynthesis.

    Objective: The melanogenesis inhibitory activity of osthol, a major coumarin of the fruits of Cnidium monnieri Cusson (Umbelliferae), and optimized extraction conditions for the maximum yield from the isolation of osthol from C. monnieri fruits were investigated. Read More

    Glutathione as a skin whitening agent: Facts, myths, evidence and controversies.
    Indian J Dermatol Venereol Leprol 2016 May-Jun;82(3):262-72
    Skinnocence: The Skin Clinic, Gurgaon, Haryana, India.
    Glutathione is a low molecular weight thiol-tripeptide that plays a prominent role in maintaining intracellular redox balance. In addition to its remarkable antioxidant properties, the discovery of its antimelanogenic properties has led to its promotion as a skin-lightening agent. It is widely used for this indication in some ethnic populations. Read More

    Inhibitory effect of Cinnamomum osmophloeum Kanehira ethanol extracts on melanin synthesis via repression of tyrosinase expression.
    J Biosci Bioeng 2016 Sep 12;122(3):263-9. Epub 2016 Apr 12.
    Department of Molecular Biotechnology, Da-Yeh University, No. 168, University Rd., Dacun, Changhua 51591, Taiwan. Electronic address:
    Melanin contributes to skin color, and tyrosinase is the enzyme that catalyzes the initial steps of melanin formation. Therefore, tyrosinase inhibitors may contribute to the control of skin hyperpigmentation. The inhibition of tyrosinase activity by Cinnamomum zeylanicum extracts was previously reported. Read More

    Potential health consequences of applying mercury-containing skin-lightening creams during pregnancy and lactation periods.
    Int J Hyg Environ Health 2016 07 14;219(4-5):468-74. Epub 2016 Mar 14.
    Environmental Health Program, Research Centre, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, Riyadh 11211, Saudi Arabia. Electronic address:
    Many studies have highlighted the widespread use of skin-lightening creams containing mercury by women during and after pregnancy to remove dark spots. Women, especially pregnant and lactating mothers using these products are at risk of mercury poisoning because sometimes it has no clinical symptoms, particularly during early exposure. Studies have shown that prenatal and postnatal mercury exposure can cause permanent neurological damage in children. Read More

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