Sante Publique 2017 Apr;29(2):263-270

Introduction: Skin bleaching is a common practice in Africa, particularly in Cameroon. Studies show that it represents a danger for health, in terms of a demonstrated increased risk of dermatological diseases. However, increasing numbers of people are using skin bleaching in African cities, despite the fact that they are sometimes aware of the risk. Read More

Biochem Biophys Res Commun 2017 Sep 4;490(4):1282-1286. Epub 2017 Jul 4.

Department of Dermatology and Institute of Health Sciences, School of Medicine, Gyeongsang National University & Hospital, Jinju, Republic of Korea. Electronic address:

Melanin pigments are the primary contributors for the skin color. They are produced in melanocytes and then transferred to keratinocytes, eventually giving various colors on skin surface. Although many depigmenting and/or skin-lightening agents have been developed, there is still a growing demand on materials for reducing pigmentation. Read More

Bioorg Med Chem Lett 2017 Aug 3;27(15):3374-3377. Epub 2017 Jun 3.

College of Pharmacy and Medicinal Research Center (MRC), Chungbuk National University, Cheongju 28160, Republic of Korea. Electronic address:

We have disclosed our effort to develop caffeic acid derivatives as potent and non-toxic inhibitors of α-MSH-stimulated melanogenesis to treat pigmentation disorders and skin medication including a cosmetic skin-whitening agent. The SAR studies revealed that cyclohexyl ester and secondary amide derivatives of caffeic acid showed significant inhibitory activities. Read More

Phytomedicine 2017 Feb 20;25:29-38. Epub 2016 Dec 20.

Bioscreening Unit, Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, Thailand. Electronic address:

Background: Androgenic hair-growth contributes to secondary gender characteristics but can be troublesome in women. Inhibiting axillary hair-growth via 5-α-reductases using the Thai medicinal plant, Curcuma aeruginosa Roxb. is an attractive treatment strategy. Read More

Chem Biodivers 2017 May 5;14(5). Epub 2017 Apr 5.

Instituto de Química Orgánica, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, Ayacucho, 471, 4000, Tucumán, Argentina.

The new methylated grindelane diterpenoid, 7β-hydroxy-8(17)-dehydrogrindelic acid (1b), together with the known 7α-hydroxy-8(17)-dehydrogrindelic acid (2a), 6-oxogrindelic acid (3a), 4β-hydroxy-6-oxo-19-norgrindelic (4a), 19-hydroxygrindelic acid (5a), 18-hydroxygrindelic acid (6a), 4α-carboxygrindelic acid (7a), 17-hydroxygrindelic acid (8a), 6α-hydroxygrindelic acid (9a), 8,17-bisnor-8-oxagrindelic acid (10a), 7α,8α-epoxygrindelic acid (11a), and strictanonic acid (12a) as methyl esters were obtained from an Argentine collection of Grindelia chiloensis (Cornel.) Cabrera. Their structures and relative configurations were established on the basis of spectroscopic analysis. Read More

BMC Complement Altern Med 2017 Jan 23;17(1):71. Epub 2017 Jan 23.

Department of Cosmeceutics, China Medical University, Taichung, 404, Taiwan.

Background: The derivative of caffeamide exhibits antioxidant and antityrosinase activity. The activity and mechanism of N-(4-methoxyphenyl) caffeamide (K36E) on melanogenesis was investigated.

Methods: B16F0 cells were treated with various concentrations of K36E; the melanin contents and related signal transduction were studied. Read More

Clin Nephrol 2017 Apr;87 (2017)(4):196-201

Aim: Membranous nephropathy and minimal change disease (MCD) have been involved in mercury-induced nephrotic syndrome. IgA nephropathy is not known to be a common pathological type. In the present article, we report a case of IgA nephropathy with MCD following exposure to mercury-containing skin lightening cream. Read More

J Enzyme Inhib Med Chem 2017 Dec;32(1):403-425

a PharmaCenter Bonn , Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn , Bonn , Germany.

Melanogenesis is a process to synthesize melanin, which is a primary responsible for the pigmentation of human skin, eye and hair. Although numerous enzymatic catalyzed and chemical reactions are involved in melanogenesis process, the enzymes such as tyrosinase and tyrosinase-related protein-1 (TRP-1) and TRP-2 played a major role in melanin synthesis. Specifically, tyrosinase is a key enzyme, which catalyzes a rate-limiting step of the melanin synthesis, and the downregulation of tyrosinase is the most prominent approach for the development of melanogenesis inhibitors. Read More

J Drugs Dermatol 2016 Dec;15(12):1571-1577

Introduction: Hyperpigmentation is a primary concern for many cosmetic patients because of its high rate of occurrence and significant impact on perceived age. While 4% hydroquinone has been the gold-standard of treatment, there is a growing interest in non-hydroquinone solutions, however, many of these newer solutions fail to deliver equivalent improvement.

Methods: This double-blind, randomized, split-face study compares the effects of a new OTC non-hydroquinone lightening product (JM) to an available 4% hydroquinone lightening solution (OB) on the appearance of hyperpigmentation, texture, and ne lines and wrinkles. Read More

J Drugs Dermatol 2016 Dec;15(12):1562-1570

Background: Pigmentary changes in people of different ethnic origins are controlled by slight variations in key biological pathways leading to different outcomes from the same treatment. It is important to develop and test products for desired outcomes in varying ethnic populations.

Objectives: To develop a comprehensive product (LYT2) that affects all major biological pathways controlling pigmentation and test for clinical efficacy and safety in different ethnic populations. Read More

Arch Dermatol Res 2017 Apr 13;309(3):141-157. Epub 2017 Jan 13.

Department of Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, ul. Gronostajowa 7, 30-387, Kraków, Poland.

Recent studies revealed the cooperation between peroxisome proliferator-activated receptor gamma (PPARγ) and α-MSH signaling, which results in enhanced melanogenesis in melanocytes and melanoma cells. However, the agonists of PPARα, such as fenofibrate, exert depigmenting effect. Therefore, we aimed to check how the PPARα expression level affects the antimelanogenic activity of fenofibrate and whether PPARα modulates melanogenesis independently of its agonist. Read More

Skin Pharmacol Physiol 2016 5;29(6):300-308. Epub 2017 Jan 5.

Division of Food, Medicines and Consumer Safety, Section Medicinal Products, Scientific Institute of Public Health (IPH), Brussels, Belgium.

In Europe, hydroquinone is a forbidden cosmetic ingredient. It is, however, still abundantly used because of its effective skin-whitening properties. The question arises as to whether the quantities of hydroquinone used become systemically available and may cause damage to human health. Read More

Biosci Biotechnol Biochem 2017 Mar 4;81(3):534-540. Epub 2017 Jan 4.

b Department of Biological Science and Technology , Tokushima University Graduate School , Tokushima , Japan.

To develop new whitening agents from natural products, we screened 80 compounds derived from crude drugs in Kampo medicine in a melanin synthesis inhibition assay using murine B16 melanoma cells. The screen revealed that treatment with alisol B, a triterpene from Alismatis rhizoma, significantly decreased both melanin content and cellular tyrosinase activity in B16 cells. However, alisol B did not directly inhibit mushroom tyrosinase activity in vitro. Read More

Int J Dermatol 2017 Jan;56(1):32-39

Department of Pathology, University of Ghana School of Biomedical and Allied Health Sciences, Accra, Ghana.

Background: The practice of skin lightening has been reported from North America, Europe, Asia, and Africa. In literature, some prevalence rates exceed 50%, and both sexes are involved. Common agents used include hydroquinone, mercury, corticosteroids, and caustic agents. Read More

Chem Pharm Bull (Tokyo) 2016 ;64(12):1681-1691

Institute for Innovation, Ajinomoto Co., Inc.

In the pathway of melanin biosynthesis, cysteine (Cys) is utilized for the synthesis of pheomelanin. Accordingly, Cys is considered to suppress the formation of brown-black eumelanin. Although attempts have been made to utilize Cys and its derivatives as skin-whitening agents, their instability and odor hinders their application as a cosmetic agent. Read More

J Ethnopharmacol 2017 Jan 13;195:196-203. Epub 2016 Nov 13.

School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, PR China. Electronic address:

Ethnopharmacological Relevance: Morus australis, one of the major Morus species growing in East Asia, is rich in phenolic compounds. The extract of M. australis has been used as skin whitening components for a long period. Read More

BMC Complement Altern Med 2016 Nov 9;16(1):453. Epub 2016 Nov 9.

Department of Life and Environmental Sciences, University of Cagliari, SS 554, Bivio per Sestu, I-09042 Monserrato, Cagliari, Italy.

Background: Asphodelus microcarpus belongs to the family Liliaceae that include several medicinal plants. In the traditional medicine plants of the genus Asphodelus are used to treat skin disorders such as ectodermal parasites, psoriasis, microbial infection and for lightening freckles. In order to find novel skin depigmenting agents, the present work was carry out to evaluate antioxidant activity and tyrosinase inhibitory potential of leaves, flowers and tubers extracts of A. Read More

Pan Afr Med J 2016 23;24:159. Epub 2016 Jun 23.

Centre de Dermatologie du CHU de Treichville d'Abidjan, Côte d'Ivoire.

Introduction: Cutaneous depigmentation for cosmeticis purposes is a widespread practice among black African women. It has many complications that have been well documented for decades. However, the reasons of practitioners are not well known. Read More

Hautarzt 2016 Nov;67(11):922-924

Klinik für Dermatologie, Venerologie und Allergologie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.

Regul Toxicol Pharmacol 2016 Nov 10;81:128-135. Epub 2016 Aug 10.

Department of Epidemiology and Environmental Health, Juntendo University, Faculty of Medicine, Tokyo, Japan.

Following reports on potential risks of hydroquinone (HQ), HQ for skin lightening has been banned or restricted in Europe and the US. In contrast, HQ is not listed as a prohibited or limited ingredient for cosmetic use in Japan, and many HQ cosmetics are sold without restriction. To assess the risk of systemic effects of HQ, we examined the rat skin permeation rates of four HQ (0. Read More

PLoS One 2016 24;11(10):e0165338. Epub 2016 Oct 24.

Department of Dermatology, Renmin Hospital of Wuhan University, Wuhan, China.

Safe and effective ingredients capable of removing undesired hyperpigmentation from facial skin are urgently needed for both pharmaceutical and cosmetic purposes. Deoxyarbutin (4-[(tetrahydro-2H-pyran-2-yl) oxy] phenol, D-Arb) is a glucoside derivative of hydroquinone. Here, we investigated the toxicity and efficacy of D-Arb at the sub-cellular level (directly on melanosomes) and skin pigmentation using in vivo and in vitro models to compare with its parent compound hydroquinone (1,4-benzenediol, HQ). Read More

J Ethnopharmacol 2016 Dec 6;193:607-616. Epub 2016 Oct 6.

School of Cosmetic Science, Mae Fah Luang University, Chiang Rai, 57100 Thailand; Phytocosmetics and Cosmeceuticals Research Group, Mae Fah Luang University, Chiang Rai 57100, Thailand.

Ethnopharmacological Relevance: While rice is one of the most important global staple food sources its extracts have found many uses as the bases of herbal remedies. Rice extracts contain high levels of phenolic compounds which are known to be bioactive, some of which show cutaneous benefits and activity towards skin disorders. This study highlights an assessment of the cellular activity and clinical efficacy of rice panicle extract, providing necessary information relevant to the development of new cosmetic products. Read More

Contact Dermatitis 2016 Oct;75(4):250-3

Pharmacy Department, University Clinical Hospital Virgen de la Arrixaca, 30120 Murcia, Spain.

Int J Mol Sci 2016 Sep 1;17(9). Epub 2016 Sep 1.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.

Polydeoxyribonucleotide (PDRN), a deoxyribonucleotide polymer, is popularly used for faster healing of cutaneous wounds and boosting of neocollagenesis of photoaged skin among current dermatologic practitioners. Some patients receiving PDRN injection treatment also reported improvement of photoaging-associated mottled pigmentation (PMP). To investigate the effect of PDRN on cutaneous melanogenesis, we examined the effect of PDRN and an available product (Placentex(®)) containing PDRN on melanogenesis using human melanocytes-keratinocytes cocultures and mouse melanocytes. Read More

Int J Mol Sci 2016 Sep 1;17(9). Epub 2016 Sep 1.

Graduate School of Biotechnology, Kyung Hee University, Yongin 17104, Korea.

Solar ultraviolet (UV) radiation is a main extrinsic factor for skin aging. Chronic exposure of the skin to UV radiation causes the induction of matrix metalloproteinases (MMPs), such as MMP-1, and consequently results in alterations of the extracellular matrix (ECM) and skin photoaging. Flavonoids are considered as potent anti-photoaging agents due to their UV-absorbing and antioxidant properties and inhibitory activity against UV-mediated MMP induction. Read More

BMJ 2016 Aug 31;354:i4386. Epub 2016 Aug 31.

Departments of dermatology and histopathology, Hillingdon Hospitals NHS Foundation Trust, Uxbridge, UK.

J Cosmet Dermatol 2016 Dec 6;15(4):527-539. Epub 2016 Aug 6.

Department of Dermatology, Frimley Park Hospital NHS Foundation Trust, Frimley, UK.

Facial rejuvenation can be categorized into skincare and facial contouring. Research and development of cosmeceuticals is aimed at addressing the major signs of photoaging: wrinkles, dyschromia, and sallowness. Assessment of photoaging comes in clinical and photographic forms; a photonumeric scale developed by Griffiths et al. Read More

Contact Dermatitis 2016 Sep;75(3):187-8

Department of Dermatology, Tokyo Medical University, 160-0023 Tokyo, Japan.

Environ Res 2016 Oct 1;150:403-10. Epub 2016 Jul 1.

Département de sciences biologiques, Université de Montréal, Montréal, QC, Canada H2V 2S9. Electronic address:

Skin lightening products are types of cosmetics (creams, gels, lotions and soaps) applied voluntarily on skin. Several of these products contain a variety of active ingredients that are highly toxic. Among those toxic agents, the present study focuses on mercury, hydroquinone, and clobetasol propionate. Read More

J Food Sci 2016 Aug 29;81(8):H2085-92. Epub 2016 Jun 29.

Ilhwa Co., BioTech Research Inst., Foreign Business Center, 25, Angol-ro 56 beon-gil, Guri-si, Gyeonggi-do, Korea.

GINST is a hydrolyzed ginseng extract produced by an in vitro process that imitates the metabolic function of bacteria in the human digestive track and has approved by the Ministry of Food and Drug Safety of Korea for the management of postprandial hyperglycemia. Additionally, GINST has been reported to have other physiological functions including anti-aging and antioxidant effects. The objectives of this study are to compare the antimelanogenic effects of fresh ginseng extract (FGE) and GINST extract and to elucidate the functional mechanism. Read More

J Cosmet Dermatol 2016 Dec 28;15(4):493-502. Epub 2016 Jun 28.

Department of Cosmetic Raw Materials Chemistry, Faculty of Pharmacy, Medical University of Lodz, Lodz, Poland.

Background: Hyperpigmentations are disorders displayed with a change in the color of the skin, its strange shape, the lack of symmetry, and irregular placement. They appear no matter on the age, gender, and often as a congenital defect. Disorder connected with overproduction of melanin by pigmentary cells. Read More

Dermatol Surg 2016 Jul;42(7):853-7

Department of Dermatology, University Hospital, Zurich, Switzerland.

Background: Quality-switched (QS) laser therapy is a safe and well-established treatment option for removing solar lentigines. Triple combination therapy (TCT) with the active pharmaceutical ingredients hydroquinone 5%, tretinoin 0.03%, and dexamethasone 0. Read More

Dermatol Surg 2016 Jul;42(7):867-74

*Department of Nutrition and Health Sciences, Chang Gung University of Science and Technology, Taoyuan, Taiwan; †Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan; ‡Department of Anatomy, College of Medicine, Chang Gung University, Taoyuan, Taiwan; §Department of Cosmetic Science, Chang Gung University of Science and Technology, Taoyuan, Taiwan; ‖College of Medicine, Chang Gung University, Taoyuan, Taiwan; ¶Department of Dermatology, Aesthetic Medical Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Background: Laser pretreatment of skin can be used to enable drugs used in dermatology to penetrate the skin to the depth necessary for their effect to take place.

Objective: To compare the permeation of tranexamic acid after conventional non-fractionated ablative Er:YAG and CO2 laser pretreatment in a laser-aided transdermal delivery system.

Materials And Methods: An erbium-doped yttrium aluminium garnet (Er:YAG) and a CO2 laser were used to pretreat dorsal porcine skin. Read More

J Dermatol Sci 2016 Aug 3;83(2):157-9. Epub 2016 May 3.

Department of Dermatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

Pharm Biol 2016 Aug 4;54(8):1373-9. Epub 2016 May 4.

a College of Pharmacy, Chungbuk National University , Cheongju , Korea ;

Context: Coumarin derivatives have been reported to inhibit melanin biosynthesis.

Objective: The melanogenesis inhibitory activity of osthol, a major coumarin of the fruits of Cnidium monnieri Cusson (Umbelliferae), and optimized extraction conditions for the maximum yield from the isolation of osthol from C. monnieri fruits were investigated. Read More

Indian J Dermatol Venereol Leprol 2016 May-Jun;82(3):262-72

Skinnocence: The Skin Clinic, Gurgaon, Haryana, India.

Glutathione is a low molecular weight thiol-tripeptide that plays a prominent role in maintaining intracellular redox balance. In addition to its remarkable antioxidant properties, the discovery of its antimelanogenic properties has led to its promotion as a skin-lightening agent. It is widely used for this indication in some ethnic populations. Read More

J Biosci Bioeng 2016 Sep 12;122(3):263-9. Epub 2016 Apr 12.

Department of Molecular Biotechnology, Da-Yeh University, No. 168, University Rd., Dacun, Changhua 51591, Taiwan. Electronic address:

Melanin contributes to skin color, and tyrosinase is the enzyme that catalyzes the initial steps of melanin formation. Therefore, tyrosinase inhibitors may contribute to the control of skin hyperpigmentation. The inhibition of tyrosinase activity by Cinnamomum zeylanicum extracts was previously reported. Read More

JAMA Dermatol 2016 Apr;152(4):372

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida.

Aust Fam Physician 2016 Apr;45(4):206-7

FRACP, is Senior Staff Specialist, Endocrinology and Obstetric Medicine, Mater Hospital, Brisbane, Queensland.

J Pharm Pharmacol 2016 Apr 19;68(4):503-13. Epub 2016 Mar 19.

Department of Preventive Pharmacy and Toxicology, College of Pharmacy, Kyung Hee University, Seoul, Korea.

Objectives: Pharmacological studies of Aster spathulifolius Maxim(AS) have demonstrated its anti-allergy, anti-viral and anti-obesity effects, however, its anti-melanogenic effects is still unclear. In this study, the effects of AS extract (ASE) on the inhibition of melanin synthesis were investigated in vitro and in vivo.

Methods: To perform this study, the contents of melanin and tyrosinase activity were analysed in B16F10 melanoma cells. Read More

Br J Dermatol 2016 Aug 10;175(2):334-9. Epub 2016 Jul 10.

Department of Dermatology, Graduate School of Medicine, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.

Background: Many users in Japan of skin brightening/lightening cosmetics containing rhododendrol (RD) have developed leucoderma. Leucoderma appears on skin areas repeatedly treated with RD-containing cosmetics. RD-induced leucoderma (RDIL) presents different degrees of well-defined hypopigmentation. Read More

Ann Dermatol Venereol 2016 Apr 14;143(4):318-20. Epub 2016 Mar 14.

Service de dermatologie, hôpital universitaire de Saint-Étienne, 42055 Saint-Étienne cedex 2, France.

Afr Health Sci 2015 Dec;15(4)

Afr Health Sci 2015 Dec;15(4):1074-80

Women's and Children's Health, Uppsala University, Sweden.

Background: Skin bleaching is a widespread phenomenon in spite of their potentially toxic health effects.

Objectives: This study aimed to determine if such products are used in Sweden in particular by pregnant women, furthermore to explore immigrant women's view skin bleaching.

Methods: 455 pregnant women completed a questionnaire, which were statistically analysed. Read More

J Eur Acad Dermatol Venereol 2016 Jun 8;30(6):943-50. Epub 2016 Mar 8.

Department of Toxicology, Dermato-Cosmetology and Pharmacognosy, Centre for Pharmaceutical Research (CePhar), Vrije Universiteit Brussel (VUB), Brussels, Belgium.

Lightening skin tone is an ancient and well-documented practice, and remains common practice among many cultures. Whitening agents such as corticosteroids, tretinoin and hydroquinone are medically applied to effectively lighten the skin tone of hyperpigmented lesions. However, when these agents are used cosmetically, they are associated with a variety of side-effect. Read More

J Dermatol Sci 2016 May 12;82(2):115-22. Epub 2016 Feb 12.

GENZ-Group of Research on Enzymology, Department of Biochemistry and Molecular Biology-A, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, E-30100 Espinardo, Murcia, Spain(1). Electronic address:

Background: Tyrosinase is an enzyme involved in the first steps of the melanogenesis process. It catalyzes the hydroxylation of monophenols to o-diphenols and the oxidation of the latter to o-quinones. Ellagic acid (EA) is a phenolic compound which has been described as a tyrosinase inhibitor and is used in the cosmetic industry as a whitening agent. Read More

Int J Cosmet Sci 2016 Aug 5;38(4):421-8. Epub 2016 Apr 5.

Department of Chemistry, Government College University, Lahore, 54000, Pakistan.

Background: A simple, new and efficient reversed-phase high-performance liquid chromatography method was developed and validated for the separation of most popular ingredients in skin whitening creams.

Methods: For RP-HPLC analysis, a Hibar(®) C18 250 mm × 4.6 mm, 5 μm column (Merck Millipore, Carolina, USA) as stationary phase with a mobile phase consisting a mixture of acetonitrile, methanol and water 40 : 40 : 20 (pH 7. Read More

Int J Biol Macromol 2016 May 30;86:383-9. Epub 2016 Jan 30.

School of Bio Sciences and Technology, VIT University, Vellore 632014, Tamil Nadu, India. Electronic address:

Excessive melanin production leads to hyperpigmentation disorders which results in distressing aesthetic values. Though there are some synthetic depigmentation agents available it has been reported to possess cytotoxic and mutagenic effects. Hence there is a need for the development of safe and non toxic natural tyrosinase inhibitors. Read More

Int J Cosmet Sci 2016 Oct 4;38(5):444-51. Epub 2016 Mar 4.

L'Oréal Research and Innovation, 1 Avenue Eugène Schueller, 93601 Aulnay sous Bois, France.

Objective: The roots of the herb Paeonia lactiflora ('White Peony') are used in association with other herbs in traditional clinical cosmetic practice in China as oral treatment for skin pigmentary disorders, such as brown or dark pigmentary spots. However, the skin-depigmenting potential of Paeonia lactiflora root extract and its main ingredient paeoniflorin has been scarcely investigated by topical application. The purpose of this study was to evaluate the efficacy of Paeonia lactiflora root extract and paeoniflorin as skin whitening agent in cosmetic application. Read More

Melanoma Res 2016 Jun;26(3):211-22

aLaboratory of Cellular and Molecular Biology, Faculty of Dental Medicine bUnit of Natural and Bioactive Substances and Biotechnology, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia cLaboratory of Pharmacognosy, Faculty of Pharmacy, University of Lille 2, Lille, France.

The lack of an efficient agent that does not have the disadvantage of low activity (kojic acid), high cytotoxicity, and mutagenicity (hydroquinone), poor skin penetration (arbutin), or low stability in formulation (glabridin) led us to continue our research on new antipigmentation/skin-lightening agents. Therefore, research of natural products that can modulate the metabolism of pigmentation is of great interest. Otherwise, malignant melanoma is one of the most aggressive forms of skin cancer, with high metastatic potential, and currently, there is no effective chemotherapy against invasive melanoma. Read More