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    Adipose-derived aldehyde dehydrogenase-expressing cells promote dermal regenerative potential with collagen-glycosaminoglycan scaffold.
    Wound Repair Regen 2016 Nov 7. Epub 2016 Nov 7.
    The Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School.
    Aldehyde dehydrogenase (ALDH) is an enzyme that plays an important role in retinoid metabolism and highly expressed in stem cells. This study isolated ALDH-expressing cells from subcutaneous adipose tissue and investigated their potential to enhance healing in a full-thickness skin wound in rats by co-implanting them with collagen-glycosaminoglycan (c-GAG) scaffolds. ALDH-positive cells were isolated by a fluorescence-activated cell sorting technique from Lewis rat's stromal-vascular-fraction (SVF) and transplanted with c-GAG scaffolds in a rat full-thickness skin wound model. Read More

    Cultured Human Epidermis Combined With Meshed Skin Autografts Accelerates Epithelialization and Granulation Tissue Formation in a Rat Model.
    Ann Plast Surg 2017 Feb 23. Epub 2017 Feb 23.
    From the *Department of Plastic and Reconstructive Surgery, Kyoto University Graduate School of Medicine, Syogoin Sakyo-ku, Kyoto; †Department of Plastic and Reconstructive Surgery, Kansai Medical University, Hirakata, Osaka; and ‡Japan Tissue Engineering, Co., Ltd., Miyakitadori, Gamagori, Aichi, Japan.
    Introduction: As the take rate of cultured epidermal autografts in burn wound treatment is variable, widely expanded meshed auto skin grafts are often used in combination with cultured epidermal autograft to increase the take rate and achieve definitive wound coverage. However, a long time (3-4 weeks) required to prepare a cultured epidermis sheet is a disadvantage. Allogeneic cultured epidermis can be prepared in advance and cryopreserved to be used in combination with auto meshed skin grafts for treating third-degree burns. Read More

    Prospects of Phage Application in the Treatment of Acne Caused by Propionibacterium acnes.
    Front Microbiol 2017 8;8:164. Epub 2017 Feb 8.
    Bacteriophage Laboratory, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of SciencesWroclaw, Poland; Phage Therapy Unit, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of SciencesWroclaw, Poland; Department of Clinical Immunology, Transplantation Institute, Medical University of WarsawWarsaw, Poland.
    Propionibacterium acnes is associated with purulent skin infections, and it poses a global problem for both patients and doctors. Acne vulgaris (acne) remains a problem due to its chronic character and difficulty of treatment, as well as its large impact on patients' quality of life. Due to the chronic course of the disease, treatment is long lasting, and often ineffective. Read More

    Two faces of gamma-delta mycosis fungoides: before and after renal transplantation.
    BMJ Case Rep 2017 Feb 22;2017. Epub 2017 Feb 22.
    Department of Dermatology and Venereology, Karl Landsteiner University of Health Sciences, Sankt Pölten, Austria.
    We describe a patient with a 30-year history of mycosis fungoides (MF) and renal transplantation performed 3 years before he presented with an ulcerated tumour in the lumbosacral area. Biopsy revealed a lymphatic infiltrate of medium-sized, pleomorphic T cells expressing the gamma-delta T-cell receptor. Radiological staging and bone marrow biopsy revealed no extracutaneous involvement. Read More

    Using Grafts and Granulation to Improve Nasal Repair.
    Facial Plast Surg 2017 Feb 22;33(1):20-26. Epub 2017 Feb 22.
    Department of Dermatology, Saint Louis University School of Medicine Ringgold Standard Institution, Saint Louis, Missouri.
    Skin grafts offer a dynamic repair option for nasal defects of appropriate size, depth, and location. Granulation and grafting can successfully be used as stand-alone reconstructive options or in conjunction with flap repair. This article reviews suitable indications for graft and granulation use in nasal repair to achieve optimum functional and esthetic outcomes. Read More

    A new option for definitive burn wound closure - pair matching type of retrospective case-control study of hand burns in the hospitalised patients group in the Dr Stanislaw Sakiel Centre for Burn Treatment between 2009 and 2015.
    Int Wound J 2017 Feb 21. Epub 2017 Feb 21.
    Department of Biochemistry, Medical University of Silesia in Katowice, School of Medicine with the Division of Dentistry in Zabrze, Zabrze, Poland.
    Nearly 80% of all burns include the hands of affected individuals. Skin grafting is the gold standard in burns treatment, but in the case of the burn wound bed, it may require the necessity of utilising skin substitutes to facilitate closure. The aim of this study is to assess the impact of a porcine-derived wound dressing (Oasis™) for application to hand burns compared to a synthetic dressing (Suprathel™). Read More

    Trichoblastoma Cutis in a Renal Transplant Recipient: A Case Report.
    Transplant Proc 2017 Mar;49(2):378-379
    Department of Nephrology, Arterial Hypertension, Dialysis, and Transplantation, University Hospital Centre Zagreb and School of Medicine, University of Zagreb, Zagreb, Croatia. Electronic address:
    Trichoblastoma is rare, benign skin neoplasm that may be difficult to distinguish from malignant baso-cellular skin cancer. Renal transplant recipients are at increased risk for development of skin malignancies. Resection and histopathological evaluation of a suspicious lesion is mandatory to determine malignant skin changes. Read More

    Living-Donor Lung Transplantation After Bone Marrow Transplantation for Chediak-Higashi Syndrome.
    Ann Thorac Surg 2017 Mar;103(3):e281-e283
    Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan. Electronic address:
    An 8-year-old girl with Chediak-Higashi syndrome (CHS) had pulmonary complications after hematopoietic stem cell transplantation (HSCT) for hemophagocytic lymphohistiocytosis (HLH) and eventually underwent single living-donor lobar lung transplantation (LDLLT). Electron micrographic findings showed vagus nerve tissue in extracted lung having granular inclusions, which are pathognomonic for CHS. Because her mother was the donor for both hematopoietic stem cell and lung transplantations, she was weaned from immunosuppression and is doing well 3 years after lung transplantation. Read More

    [Outcome of relaying anterolateral thigh perforator flap in resurfacing the donor site wound following free anteromedial thigh perforator flap transfer for reconstruction of defect after oral tumor radical resection].
    Zhonghua Shao Shang Za Zhi 2017 Feb;33(2):72-76
    Department of Oncologic Plastic Surgery, Hunan Cancer Hospital, Changsha 410008, China.
    Objective: To observe the outcome of relaying anterolateral thigh (ALT) perforator flap in resurfacing the donor site wound following free anteromedial thigh (AMT) perforator flap transfer for reconstruction of defect after oral tumor radical resection. Methods: From January 2013 to January 2016, 28 patients with oral tumor underwent radical resection in our hospital, leaving defects with size ranged from 6.5 cm×3. Read More

    [Analysis of the application and funding projects of National Natural Science Foundation of China in the field of burns and plastic surgery from 2010 to 2016].
    Zhonghua Shao Shang Za Zhi 2017 Feb;33(2):65-67
    Department of Critical Care Medicine, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China.
    We analyzed the data of application and funding projects of the National Natural Science Foundation of China (NSFC) during 2010-2016 in the field of burns and plastic surgery and summarized the NSFC funding pattern, the research hotspots, and weaknesses in this field. The NSFC has funded 460 projects in the field of burns and plastic surgery, with total funding of RMB 227.96 million. Read More

    Treatment of standardised wounds with pure epidermal micrografts generated with an automated device.
    Int Wound J 2017 Feb 20. Epub 2017 Feb 20.
    Department of Plastic and Hand Surgery and Laboratory for Tissue Engineering and Regenerative Medicine, University Hospital Erlangen, Friedrich-Alexander-University of Erlangen-Nuernberg (FAU), Erlangen, Germany.
    In this study, we analysed the effects of pure epidermal micrografts generated with an automated device in a standardised human wound model. Epidermal micrografts were harvested using an automated device. Micrografts were then transplanted onto split-skin donor sites. Read More

    Innovative modified hair follicle harvesting technique with reverse rake scalp elevator for lower occipital donor area in follicular unit extraction hair transplantation.
    Indian J Plast Surg 2016 Sep-Dec;49(3):390-396
    Department of Plastic Surgery, Grant Government Medical College and Sir J. J. Group of Hospitals, Mumbai, Maharashtra, India.
    Follicular unit extraction (FUE) is one of the widely practiced minimally invasive follicular harvesting techniques employed during hair transplantation. FUE technique has an advantage of utilising lower occipital area and supra-auricular region as a safe donor area described by Unger, in addition to the standard occipital donor area used in strip method (follicular unit transplant). Despite its potential advantages such as rapid recovery, minimal scarring and reduced post-operative pain; its widespread acceptance is limited due to various factors in variable contribution like steeper learning curve and potentially higher follicular transection rates (FTRs). Read More

    Siliconomas of the lower limb: Tumour-like excision and reconstruction.
    Indian J Plast Surg 2016 Sep-Dec;49(3):384-389
    Department of Plastic and Reconstructive Surgery, Centro Chirurgico San Paolo, Pistoia, Italy.
    Background: Silicone oil injection can cause several complications including pain, cellulitis, abscesses, skin compromise, migration, embolism and multiorgan failure. Oil-infested tissue excision remains the solely treatment to prevent such complications.

    Objectives: The authors evaluate tumor-like excision of the oil-infested tissue as a treatment for patients experiencing silicone injections in the lower limbs, to both preserve aesthetic appearance and solve further risk of complication from silicone. Read More

    Production of sperm from porcine fetal testicular tissue after cryopreservation and grafting into nude mice.
    Theriogenology 2017 Mar 30;91:154-162. Epub 2016 Dec 30.
    Laboratory of Animal Reproduction, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, Japan.
    A major goal of testicular xenografting is to salvage germ cells from immature animals that cannot be used for reproduction and generate their offspring. In this study, we investigated whether porcine fetal testicular tissue would acquire the ability to produce sperm with full developmental competence after they had been cryopreserved and grafted into nude mice. Testicular fragments from fetuses at 35, 55 and 90 days postartificial insemination (dpi) were vitrified and stored in liquid nitrogen. Read More

    Scabies in a bilateral hand allograft recipient: An additional mimicker of acute skin rejection in vascularized composite allotransplantation.
    Transpl Infect Dis 2017 Feb 17. Epub 2017 Feb 17.
    Department of Nephrology, Edouard Herriot Hospital Group, Lyon, France.
    Vascularized composite tissue allografts include skin, which frequently undergoes, in the early post-graft period, acute rejections. The diagnosis of acute rejection may be difficult as it can be mimicked by several dermatoses. We present a bilateral hand allograft recipient who developed, 16. Read More

    The Efficacy of a Prevascularized, Retrievable Poly(D,L,-lactide-co-ε-caprolactone) Subcutaneous Scaffold as Transplantation Site for Pancreatic Islets.
    Transplantation 2017 Feb 15. Epub 2017 Feb 15.
    1 PhD, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands 2 MSc, Department of Surgery, University of California Irvine, Orange, USA 3 MSc, Polyganics, Groningen, The Netherlands 4 BSc, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands 5 PhD, Polyganics, Groningen, The Netherlands 6 PhD, Department of Developmental BioEngineering, Faculty of Science and Technology, University of Twente, Enschede, The Netherlands 7 Professor, Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands 8 PhD, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands 9 Professor, Department of Biomedical Engineering, University of California Irvine, Irvine, USA and Department of Surgery, University of California Irvine, Orange, USA 10 Professor, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
    Background: The liver as transplantation site for human pancreatic islets is a harsh microenvironment for islets and it lacks the ability to retrieve the graft. A retrievable, extrahepatic transplantation site that mimics the pancreatic environment is desired. Ideally this transplantation site should be located subdermal for easy surgical-access but this never resulted in normoglycemia. Read More

    Association Between Pretransplant Cancer and Survival in Kidney Transplant Recipients.
    Transplantation 2017 Feb 15. Epub 2017 Feb 15.
    1Department of Transplant Medicine, Oslo University Hospital, Oslo, Norway; 2The Cancer Registry of Norway, Oslo, Norway. 3Norwegian Renal Registry, Oslo University Hospital, Oslo, Norway. 4Department of Internal Medicine, Ringerike Hospital, Vestre Viken Hospital Trust, Norway.
    Background: Kidney transplantation in recipients with a previous malignancy is often deferred 2-5 years after cancer treatment due to fear of cancer recurrence. In Norway, the required waiting period has been 1 year.

    Methods: We compared patient and graft survival of recipients with pretransplant cancer to the outcomes of matched recipients without such cancer (comparators) using Cox regression. Read More

    Postero-Inferior Pedicle Surgical Technique for the Treatment of Grade III Gynecomastia.
    Aesthetic Plast Surg 2017 Feb 15. Epub 2017 Feb 15.
    Department of Plastic, Reconstructive and Aesthetic Surgery, Hospital Sud, University of Rennes 1, 16 Boulevard de Bulgarie, 35200, Rennes, France.
    Introduction: Surgical treatment of Grade III gynecomastia generally utilizes mastectomy techniques and free transplantation of the nipple-areola complex. Moreover, with rising obesity rates and the development of bariatric surgery, an increasing demand for correctional surgery for pseudogynecomastia has been observed, which is comparable to Grade III gynecomastia in terms of its surgical management. Here, we describe an innovative technique to deal with these new demands: fascio-cutaneous flap by postero-inferior pedicle. Read More

    Partial Breast Reconstruction with Goldilocks Technique After Excision of Giant Fibroadenoma: A Case Report.
    Plast Reconstr Surg Glob Open 2017 Jan 25;5(1):e1200. Epub 2017 Jan 25.
    Department of Plastic Surgery, Georgetown University Hospital, Wash.; and Department of Surgery, Fairfax Virginia Inova Fairfax Hospital, Falls Church, Va.
    Giant juvenile fibroadenomas are relatively rare, accounting for less than 1% fibroadenomas. Large breast tumors create significant asymmetry and provide unique reconstructive challenges after removal. In this case, we describe a 21-year-old female with delayed presentation of a giant fibroadenoma of the right breast. Read More

    Systematic review and meta-analysis of the efficacy of epidermal grafting for wound healing.
    Int Wound J 2017 Feb 15. Epub 2017 Feb 15.
    Division of Surgery & Interventional Science, University College London, London, UK.
    Autologous skin grafting is an important method for wound coverage; however, it is an invasive procedure and can cause donor site morbidity. Epidermal grafting (EG) enables epidermal transfer to wounds with minimal donor site morbidity. However, data to date have been heterogeneous. Read More

    Hepatitis B viremia manifesting as polyarteritis nodosa and secondary membranous nephropathy.
    J Nephropharmacol 2016 14;5(2):119-121. Epub 2016 Jan 14.
    Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Center, Dr. HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad, India.
    Renal involvement in hepatitis B-polyarteritis nodosa (HBV-PAN) usually occurs in the form of hypertension, microscopic hematuria, proteinuria but nephrotic range proteinuria or renal failure is very uncommon. A 60-year-old man had abdominal pain for 15 days which was followed by bilateral pedal edema in a day and in next three days he had sudden onset bilateral foot drop with numbness. He had weight loss of 10 kg in last 20 days. Read More

    Treatment of Infantile Inflammatory Bowel Disease and Autoimmunity by Allogeneic Stem Cell Transplantation in LPS-Responsive Beige-Like Anchor Deficiency.
    Front Immunol 2017 31;8:52. Epub 2017 Jan 31.
    Division for Pediatric Stem-Cell Transplantation and Immunology, University Hospital Frankfurt , Frankfurt/Main , Germany.
    Inflammatory bowel disease (IBD) in young children can be a clinical manifestation of various primary immunodeficiency syndromes. Poor clinical outcome is associated with poor quality of life and high morbidity from the complications of prolonged immunosuppressive treatment and malabsorption. In 2012, mutations in the lipopolysaccharide-responsive beige-like anchor (LRBA) gene were identified as the cause of an autoimmunity and immunodeficiency syndrome. Read More

    Generation of Human Induced Pluripotent Stem Cell-Derived Bona Fide Neural Stem Cells for Ex Vivo Gene Therapy of Metachromatic Leukodystrophy.
    Stem Cells Transl Med 2017 Feb 16;6(2):352-368. Epub 2016 Sep 16.
    San Raffaele Telethon Institute for Gene Therapy, Division of Regenerative Medicine, Stem Cells and Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele, Milan, Italy.
    Allogeneic fetal-derived human neural stem cells (hfNSCs) that are under clinical evaluation for several neurodegenerative diseases display a favorable safety profile, but require immunosuppression upon transplantation in patients. Neural progenitors derived from patient-specific induced pluripotent stem cells (iPSCs) may be relevant for autologous ex vivo gene-therapy applications to treat genetic diseases with unmet medical need. In this scenario, obtaining iPSC-derived neural stem cells (NSCs) showing a reliable "NSC signature" is mandatory. Read More

    Enhanced Expansion and Sustained Inductive Function of Skin-Derived Precursor Cells in Computer-Controlled Stirred Suspension Bioreactors.
    Stem Cells Transl Med 2017 Feb 9;6(2):434-443. Epub 2016 Sep 9.
    Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada.
    Endogenous dermal stem cells (DSCs) reside in the adult hair follicle mesenchyme and can be isolated and grown in vitro as self-renewing colonies called skin-derived precursors (SKPs). Following transplantation into skin, SKPs can generate new dermis and reconstitute the dermal papilla and connective tissue sheath, suggesting they could have important therapeutic value for the treatment of skin disease (alopecia) or injury. Controlled cell culture processes must be developed to efficiently and safely generate sufficient stem cell numbers for clinical use. Read More

    A case report of primary necrotising fasciitis of the breast: A rare but deadly entity requiring rapid surgical management.
    Int J Surg Case Rep 2017 Jan 23;31:221-224. Epub 2017 Jan 23.
    Blacktown Hospital, NSW, Australia.
    Introduction: Necrotising fasciitis of the breast is a rare entity with very few cases reported in the literature. It is rapidly progressive and can lead to sepsis and multi-organ failure without prompt medical and surgical management.

    Presentation Of Case: We describe a case of a non-diabetic 23-year-old female with primary necrotising fasciitis of the right breast. Read More

    Blockade of p38 Mitogen-Activated Protein Kinase Inhibits Murine Sclerodermatous Chronic Graft-versus-Host Disease.
    Am J Pathol 2017 Feb 9. Epub 2017 Feb 9.
    Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
    Bone marrow transplantation (BMT) of B10.D2 mice into sublethally irradiated BALB/c mice across minor histocompatibility loci is a well-established animal model for human sclerodermatous chronic graft-versus-host disease (Scl-cGVHD) and systemic sclerosis (SSc). The p38 mitogen-activated protein kinase (MAPK) pathway is a key regulator of inflammation and cytokine production. Read More

    PD1 blockade with pembrolizumab is highly effective in relapsed or refractory NK/T-cell lymphoma failing L-asparaginase.
    Blood 2017 Feb 10. Epub 2017 Feb 10.
    Department of Medicine, Queen Mary Hospital, Hong Kong.
    Natural killer (NK)/T-cell lymphomas failing L-asparaginse-regimens have no known salvage and are almost invariably fatal. Seven male NK/T-cell lymphoma patients (age: 49, 31-68, years) failing 2 (1-5) regimens (including L-asparaginase-regimens, and allogeneic hematopoietic stem cell transplantation, HSCT, in 2 cases), were treated with the anti-programmed-death-1 (PD1) antibody pembrolizumab. All patients responded, according to various clinical, radiologic (positron emission tomography), morphologic and molecular (circulating Epstein-Barr virus, EBV, DNA) criteria. Read More

    Skin-Derived Precursors as a Source of Progenitors for Corneal Endothelial Regeneration.
    Stem Cells Transl Med 2017 Feb 6. Epub 2017 Feb 6.
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
    Corneal blindness is the fourth leading cause of blindness in the world. Current treatment is allogenic corneal transplantation, which is limited by shortage of donors and immunological rejection. Skin-derived precursors (SKPs) are postnatal stem cells, which are self-renewing, multipotent precursors that can be isolated and expanded from the dermis. Read More

    The benefits of ultrasound-guided continuous sensory nerve blockade in the setting of burn injury: a case report of bilateral continuous superficial peroneal nerve blockade in a patient with severe sleep apnea.
    J Clin Anesth 2017 Feb 22;36:62-66. Epub 2016 Nov 22.
    University of Pittsburgh Medical Center Mercy Hospital, 1400 Locust St, Pittsburgh, PA 15219.
    The management of pain after burn injuries is a clinical challenge magnified in patients with significant comorbidities. Presently, burn pain is treated via a wide variety of modalities, including systemic pharmacotherapy and regional analgesia. Although the latter can provide effective pain control in patients with burn injuries, it is relatively underused. Read More

    Blood loss and transfusion requirements with epsilon-aminocaproic acid use during cranial vault reconstruction surgery.
    J Clin Anesth 2017 Feb 3;36:153-157. Epub 2016 Dec 3.
    Covenant Children's Hospital, Lubbock, TX; Department of Otolaryngology, Division of Facial Plastic and Reconstructive Surgery, Texas Tech University Health Sciences Center, Lubbock, TX.
    Objective: To determine whether epsilon-aminocaproic acid (EACA) load of 50 mg∙kg(-1) before skin incision, and infusion of 25 mg∙kg(-1)∙h(-1) until skin closure during cranial vault reconstruction (CVR) were associated with decreased estimated blood loss and transfusion requirements.

    Background: Antifibrinolytic medications decrease bleeding and transfusion requirements during cardiothoracic and orthopedic surgeries with high blood loss, but practical reductions in blood loss and transfusion requirements have not been consistently realized in children undergoing CVR. Current dosing recommendations are derived from adult extrapolations, and may or may not have clinical relevance. Read More

    Factors that Affected Functional Outcome After a Delayed Excision and Split-Thickness Skin Graft on the Dorsal Side of Burned Hands.
    J Burn Care Res 2017 Feb 7. Epub 2017 Feb 7.
    From the *Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan; †Department of Plastic and Reconstructive Surgery, Sapporo City General Hospital, Japan; and ‡Department of Plastic and Reconstructive Surgery, Hakodate Central General Hospital, Japan.
    Early excision and skin grafting is the principle treatment for a burned hand although there are occasions when it cannot be done such as severe general condition, delayed consultation, and the lack of a definitive assessment of burn depth. This study analyzes the factors that affected function after a delayed excision and skin graft for hands with a deep dermal burn. This study retrospectively evaluated 43 burned hands that required a delayed excision and split-thickness skin graft on the dorsal side. Read More

    Efficacy of bubaline fibrin glue on full-thickness pinch and punch skin grafting in a pig.
    J Biomater Appl 2017 Jan 1:885328217693126. Epub 2017 Jan 1.
    1 Department of Surgery, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.
    Fibrin glue, which is formed from the action of thrombin (a serine protease) on fibrinogen, has been developed for use as an adhesive to increase the success of skin graft surgery. The objective of this study was to evaluate if bubaline fibrin glue would promote skin graft survival in pigs. The grafting was divided into two steps. Read More

    Multicenter Systems Analysis of Human Blood Reveals Immature Neutrophils in Males and During Pregnancy.
    J Immunol 2017 Feb 8. Epub 2017 Feb 8.
    Division of Translational Medicine, Department of Systems Biology, Sidra Medical and Research Center, 26999 Doha, Qatar;
    Despite clear differences in immune system responses and in the prevalence of autoimmune diseases between males and females, there is little understanding of the processes involved. In this study, we identified a gene signature of immature-like neutrophils, characterized by the overexpression of genes encoding for several granule-containing proteins, which was found at higher levels (up to 3-fold) in young (20-30 y old) but not older (60 to >89 y old) males compared with females. Functional and phenotypic characterization of peripheral blood neutrophils revealed more mature and responsive neutrophils in young females, which also exhibited an elevated capacity in neutrophil extracellular trap formation at baseline and upon microbial or sterile autoimmune stimuli. Read More

    Fasciotomy closure techniques.
    J Orthop Surg (Hong Kong) 2017 Jan;25(1):2309499016684724
    2 Department of Orthopaedic Surgery and Rehabilitation, SUNY Downstate Medical Center, Brooklyn, New York, NY, USA.
    We evaluated the risks and success rates of the three major techniques for compartment syndrome fasciotomy closure by reviewing all literature published to date. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we systematically evaluated the Medline (PubMed) database until July 2015, utilizing the Boolean search sting "compartment syndrome OR fasciotomy closure." Two authors independently assessed all studies published in the literature to ensure validity of extracted data. Read More

    Serum-free bioprocessing of adult human and rodent skin-derived Schwann cells: implications for cell therapy in nervous system injury.
    J Tissue Eng Regen Med 2017 Feb 8. Epub 2017 Feb 8.
    Pharmaceutical Production Research Facility, Schulich School of Engineering, University of Calgary, Calgary, Alberta, Canada.
    Peripheral nerve injury affects 2.8% of trauma patients with severe cases often resulting in long-lived permanent disability, despite nerve repair surgery. Autologous Schwann cell (SC) therapy currently provides an exciting avenue for improved outcomes for these patients, particularly with the possibility to derive SCs from easily-accessible adult skin. Read More

    Protein-Induced Pluripotent Stem Cells Ameliorate Cognitive Dysfunction and Reduce Aβ Deposition in a Mouse Model of Alzheimer's Disease.
    Stem Cells Transl Med 2017 Jan 15;6(1):293-305. Epub 2016 Aug 15.
    Department of Biochemistry and Biomedical Sciences, Seoul National University, Seoul, Republic of Korea.
    Transplantation of stem cells into the brain attenuates functional deficits in the central nervous system via cell replacement, the release of specific neurotransmitters, and the production of neurotrophic factors. To identify patient-specific and safe stem cells for treating Alzheimer's disease (AD), we generated induced pluripotent stem cells (iPSCs) derived from mouse skin fibroblasts by treating protein extracts of embryonic stem cells. These reprogrammed cells were pluripotent but nontumorigenic. Read More

    Diagnostic potential of interferon-gamma release assay to detect latent tuberculosis infection in kidney transplant recipients.
    Transpl Infect Dis 2017 Feb 7. Epub 2017 Feb 7.
    Department of Infection and Immunity, KFSHRC, Riyadh, Saudi Arabia.
    Background: Latent tuberculosis (TB) infection (LTBI) is screened by using clinical assessment, tuberculin skin test (TST), chest radiography and recently by interferon-gamma release assays (IGRA). The objective of this study was to evaluate the diagnostic potential of QuantiFERON(®) -TB Gold In-Tube test (QFT) for diagnosing LTBI in patients planned for kidney transplantation.

    Methods: All adult patients with end-stage renal disease, evaluated for kidney transplantation in a referral center from August 2008 till May 2013, were enrolled, after consenting in a prospective, observational, non-interventional study. Read More

    Long-Term Outcome of Microautologous Fat Transplantation to Correct Temporal Depression.
    J Craniofac Surg 2017 Feb 6. Epub 2017 Feb 6.
    *Department of Plastic Surgery, Kaohsiung Medical University †Charming Institute of Aesthetic and Regenerative Surgery (CIARS) ‡Division of Traumatology, Department of Emergency, Kaohsiung Medical University §Yuan's General Hospital ||Department of Post Baccalaureate Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
    Objective: Sunken temporal fossa appears oftentimes in Asians and resembles bad fortune that people wish to change. Numerous techniques and materials have been applied clinically for augmenting the sunken temporal fossa with variable results. The microautologous fat transplantation (MAFT) technique proposed by Lin et al in 2006 has demonstrated favorable results in facial rejuvenation. Read More

    Lymphomatoid granulomatosis with pulmonary and gastrointestinal involvement.
    BMJ Case Rep 2017 Feb 6;2017. Epub 2017 Feb 6.
    Department of Pulmonology, Sint Franciscus Vlietland Groep, Rotterdam, The Netherlands.
    We present a rare case of grade II lymphomatoid granulomatosis (LYG) with pulmonary and gastrointestinal involvement. LYG is considered an Epstein-Barr virus-driven lymphoproliferative disorder that often presents with multiple nodular lesions in the lungs and sometimes involvement of skin and the central nervous system. Although the aetiology is unknown, it is associated with the use of immunosuppressives. Read More

    500-Gray γ-Irradiation May Increase Adhesion Strength of Lyophilized Cadaveric Split-Thickness Skin Graft to Wound Bed.
    Ann Plast Surg 2017 Feb 3. Epub 2017 Feb 3.
    From the *Division of Plastic Surgery, Department of Surgery, Taoyuan Armed Forces General Hospital, Taoyuan; and †Department of Plastic Surgery, Wan Fang Municipal Hospital, Taipei Medical University, Taipei, Taiwan.
    Background: Human cadaveric skin grafts are considered as the "gold standard" for temporary wound coverage because they provide a more conductive environment for natural wound healing. Lyophilization, packing, and terminal sterilization with gamma-ray can facilitate the application of cadaveric split-thickness skin grafts, but may alter the adhesion properties of the grafts. In a pilot study, we found that 500 Gy γ-irradiation seemed not to reduce the adherence between the grafts and wound beds. Read More

    Acute and Late Bartonella henselae Murine Model Infection.
    Vector Borne Zoonotic Dis 2017 Mar 6;17(3):206-208. Epub 2017 Feb 6.
    1 Division of Dermatology, Department of Medicine, University of Campinas (UNICAMP) Medical School , Campinas, Brazil .
    Bartonella spp. are fastidious gram-negative neglected bacilli with worldwide distribution. They are able to cause intraerythrocytic and potentially fatal infection. Read More

    Pathological Fracture of Calcaneum: A Case Report.
    J Orthop Case Rep 2016 Sep-Oct;6(4):92-95
    Department of Orthopaedics, Yenepoya Medical College Hospital, Deralakatte, Mangalore, Karnataka, India.
    Introduction: Aneurysmal bone cysts (ABCs) are blood filled fibrous tumor-like cysts that expand the bone giving it a blown out appearance. It is usually seen in the second decade. ABCs were first described by Jaffe and Litchensen in 1942. Read More

    Reduction of Blister Formation Time in Suction Blister Epidermal Grafting in Vitiligo Patients Using a Household Hair Dryer.
    J Cutan Aesthet Surg 2016 Oct-Dec;9(4):232-235
    Department of Skin and VD, IMS and SUM Hospital, S 'O' A University, Bhubaneswar, Odisha, India.
    Background: Suction blister epidermal grafting (SBEG) is a simple and effective way of surgical repigmentation in vitiligo. The major problem faced is the time taken for the formation of blisters. Temperature at the suction site is one of the factors affecting the blister formation time. Read More

    Adipose-derived stem cells protect skin flaps against ischemia/reperfusion injury via interleukin-6 expression.
    J Invest Dermatol 2017 Feb 2. Epub 2017 Feb 2.
    Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:
    Flap necrosis is the most frequent postoperative complication encountered in reconstructive surgery. We elucidated whether adipose-derived stem cells (ADSCs) and their derivatives might induce neovascularization and protect skin flaps during ischemia/reperfusion (I/R) injury. Flaps were subjected to 3 h of ischemia by ligating long thoracic vessels and then to blood reperfusion. Read More

    Stem cells and Bronchopulmonary Dysplasia - The five questions: Which cells, when, in which dose, to which patients via which route?
    Paediatr Respir Rev 2016 Dec 24. Epub 2016 Dec 24.
    Department of Pediatrics, Maastricht University Medical Center (MUMC), Maastricht, The Netherlands; School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands; School of Oncology and Developmental Biology (GROW), Maastricht, The Netherlands. Electronic address:
    Preterm birth is the leading cause of death in newborns and children. Despite advances in perinatology, immature infants continue to face serious risks such chronic respiratory impairment from bronchopulmonary dysplasia (BPD). Current treatment options are insufficient and novel approaches are desperately needed. Read More

    [Repair mechanisms of the wounds with exposed bone structures using an artificial dermis].
    Zhonghua Yi Xue Za Zhi 2017 Jan;97(4):308-312
    Department of Burn and Plastic Surgery, Beijing Jishuitan Hospital, Beijing 100035, China.
    Objective: To investigate the repair mechanisms of the wounds with bone exposed by artificial dermis transplantation. Methods: Seventy two rabbits were randomly divided into 3 groups of 24 rabbits, the wound model was made on the top of head. In the skin defect group (SD group), skin was removed and skull periosteum was retained. Read More

    Xenografting of isolated equine (Equus caballus) testis cells results in de novo morphogenesis of seminiferous tubules but not spermatogenesis.
    Andrology 2017 Feb 3. Epub 2017 Feb 3.
    Department of Clinical Studies, New Bolton Center, University of Pennsylvania School of Veterinary Medicine, Kennett Square, PA, USA.
    The study of spermatogenesis in the horse is challenging because of the absence of an in vitro system that is capable of reproducing efficient spermatogenesis and because of the difficulties and costs associated with performing well-controlled studies in vivo. In an attempt to develop novel methods for the study of equine spermatogenesis, we tested whether cells from enzymatically digested pre-pubertal equine testicular tissue were capable of de novo tissue formation and spermatogenesis following xenografting under the back skin of immunocompromised mice. Testes were obtained from normal pre-pubertal colts and dissociated into cell suspensions using trypsin/collagenase digestion. Read More

    Nonclinical Evaluation of the New Topical Hemostatic Agent TT-173 for Skin Grafting Procedures.
    J Burn Care Res 2017 Jan 31. Epub 2017 Jan 31.
    From the *Thombotargets Europe S.L. Mediterranean Technology Park, Castelldefels, Spain; †Unit of Human Anatomy and Embryology, Department of Morphological Sciences, Faculty of Medicine, Autonomous University of Barcelona, Cerdanyola del Vallès, Spain; ‡Molecular Imaging Research Group - Vall d'Hebron Research Institute, CIBBIM-Nanomedicine, Barcelona, Spain; §Unit of Experimental Surgery, Institute of Biomedical Investigation of A Coruña, A Coruña, Spain; and ‖Department of Plastic Surgery, University Hospital of A Coruña, A Coruña, Spain.
    Blood loss during grafting surgery represents a major concern of this procedure and the development of hemostatic agents for this indication is highly desirable. TT-173 is the first biologically active treatment based on tissue factor instead of thrombin. This study sought to investigate the efficacy, systemic absorption, and toxicology of TT-173 in animal models to support clinical evaluation of the product in donor sites of patients subjected to skin grafting. Read More

    Effect of Procedural-Related Variables on Melanocyte-Keratinocyte Suspension Transplantation in Nonsegmental Stable Vitiligo: A Clinical and Immunocytochemical Study.
    Dermatol Surg 2017 Feb;43(2):226-235
    Departments of *Dermatology, †Histology, and ‡Clinical Pathology, Kasr El-Ainy Teaching Hospital, Faculty of Medicine, Cairo University, Cario, Egypt.
    Background: Melanocyte-keratinocyte suspension (M-K susp) is gaining popularity for vitiligo treatment. Few studies have addressed procedure-related variables.

    Objective: To assess the effect of different M-K susp procedure-related variables on the clinical outcome in stable vitiligo. Read More

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