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Dermatol Surg 2021 Jun 2. Epub 2021 Jun 2.

Department of Dermatology, LTMMC and LTMGH, Sion, Mumbai, India; UBM Institute, Dadar, Mumbai, India.

Background: Hair transplantation in scarring alopecia is challenging and transplant surgeons are hesitant due to fear of poor graft survival apart from the risk of reactivating the disease.

Objective: Survival rate of hair follicles transplanted in cases of lichen planopilaris (LPP). To correlate histopathological and ultrasonography findings and their impact on graft survival. Read More

J Cosmet Dermatol 2021 Jun 11. Epub 2021 Jun 11.

Sultan Abdulhamid Han Education and Training Hospital Department of Plastic Reconstructive and Aesthetic Surgery.

Introduction: Cicatricial eyebrow loss that occurs after trauma or burns considerably reduces a person's self-confidence. Several methods, either surgical or nonsurgical, have been defined to reconstruct eyebrows. This study focused on eyebrow restoration using the atraumatic follicular unit extraction (FUE) technique in patients and emphasized certain details that should be considered during the treatment process. Read More

Stem Cell Res Ther 2021 Jun 10;12(1):341. Epub 2021 Jun 10.

Department of Plastic Surgery, Tangdu Hospital, Airforce Military Medical University, Xi'an, 710038, China.

Background: Epidermal stem cells (EpSCs) play a vital role in wound healing and skin renewal. Although biomaterial scaffolds have been used for transplantation of EpSCs in wound healing, the ex vivo differentiation of EpSCs limits their application.

Methods: To inhibit the differentiation of EpSCs and maintain their stemness, we developed an electrospun polycaprolactone (PCL)+cellulose acetate (CA) micro/nanofiber for the culture and transplantation of EpSCs. Read More

Biotechnol Bioeng 2021 Jun 10. Epub 2021 Jun 10.

Ruihua Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215104, China.

Restoration of a wound is a common surgical procedure in clinic. Currently, the skin required for clinical use is taken from the patient's own body. However, it can be difficult to obtain enough skin sources for large-sized wounds and thus surgeons have started using commercial skin substitutes. Read More

Bone Marrow Transplant 2021 Jun 9. Epub 2021 Jun 9.

Unité de Médecine Interne: Maladies Auto-immunes et Pathologie Vasculaire (UF 04), Centre de Référence des Maladies auto-immunes systémiques Rares d'Ile-de-France MATHEC, AP-HP, Hôpital Saint-Louis, Paris, France.

Two randomised trials (ASTIS, SCOT) of Autologous Hematopoietic Stem Cell Transplantation (AHSCT) versus monthly Cyclophosphamide for severe Systemic Sclerosis (SSc) patients used similar inclusion criteria, but different primary endpoints: event-free-survival (EFS) at 24 months in ASTIS versus the global rank composite score (GRCS) at 54 months in SCOT. Here we analysed the French ASTIS cohort (n = 49) outcome using the same GRCS endpoint as reported in SCOT. All patients, randomised to AHSCT (n = 26) or Cyclophosphamide (n = 23), were evaluated for the non-parametric GRCS endpoint based on: death, EFS, forced vital capacity (FVC), Health Assessment Questionnaire Disability Index (HAQ-DI) and modified Rodnan skin score (mRSS) at 60 months. Read More

Ann Palliat Med 2021 May;10(5):5341-5350

Department of Orthopaedics, Wuxi No.9 People's Hospital affiliated to Soochow University, Wuxi, China.

Background: The application of free skin flaps to repair severe peri-knee soft tissue defects is a common clinical approach. This article aims to investigate clinical efficacy and precautions of using a free anterolateral thigh flap with the descending genicular vessels as a recipient pedicle for repairing Gustilo IIIB and IIIC soft tissue defects around the knee.

Methods: We retrospectively analyzed the data of the patients with severe peri-knee Gustilo IIIB or IIIC soft tissue defects operated on from January 2015 to December 2019. Read More

Transplant Cell Ther 2021 Jun 6. Epub 2021 Jun 6.

Department of Dermatology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Background: Chronic graft-versus-host disease (cGVHD), a potentially debilitating complication of hematopoietic cell transplantation, confers increased risk for mortality. While treatment decisions rely on an accurate assessment of disease activity/severity, validated methods of assessing cutaneous cGVHD activity/severity appear to be limited.

Objective: We aimed to identify and evaluate current data on the assessment of disease activity/severity in cutaneous cGVHD Study Design: Using modified PRISMA methods, we performed critical literature review for relevant articles. Read More

Radiat Res 2021 Jun 9. Epub 2021 Jun 9.

The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, 610051, China.

Severe radiation-induced skin injury is a complication of tumor radiotherapy and nuclear accidents. Cell therapy is a potential treatment for radiation-induced skin injury. The stromal vascular fraction (SVF) is a newer material in stem cell therapy that is made up of stem cells harvested from adipose tissue, which has been shown to promote the healing of refractory wounds of different causes. Read More

Medicine (Baltimore) 2021 May;100(19):e25699

Department of Radiology.

Rationale: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an uncommon and aggressive hematologic malignancy that arises from plasmacytoid dendritic cells. BPDCN typically presents with skin lesions with or without involvement of lymph nodes, peripheral blood, or bone marrow. However, breast involvement of BPDCN is rare and there has been no report describing the radiologic features of BPDCN within breast parenchyma. Read More

Hematol Oncol 2021 Jun;39 Suppl 1:46-51

Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany.

Cutaneous T-cell lymphomas (CTCL) represent the majority of primary cutaneous lymphomas (CL). Mycosis fungoides (MF) and cutaneous CD30+ lymphoproliferative disorders account for 80% of all CTCL. CTCL show overlapping histological features. Read More

Br J Dermatol 2021 Jun 9. Epub 2021 Jun 9.

Medical University of Warsaw, Warsaw, Poland.

Background: Frontal fibrosing alopecia (FFA) has become one of the most common causes of cicatricial alopecia worldwide, but lacks clear aetiology and robust clinical trial evidence for efficacy and safety of agents currently used for treatment.

Objectives: To enable data to be collected worldwide on FFA using common criteria and assessment methods.

Methods: A multi-centre, international group of experts in hair loss was convened by email to create consensus recommendations for clinical trials. Read More

Plast Reconstr Surg Glob Open 2021 Jun 7;9(6):e3613. Epub 2021 Jun 7.

Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan.

Surgical excision of a giant congenital melanocytic nevus (GCMN) results in a full-thickness skin defect that is usually difficult to reconstruct even with tissue expansion or skin grafting. Here, we report the first case of GCMN treated with a combination of cultured epithelial autografts (CEAs) and mesh-skin grafts to reconstruct a large skin defect after surgical excision. A 14-month-old girl had a GCMN occupying 20% of the total body surface area of her neck and back. Read More

Spine (Phila Pa 1976) 2021 Jul;46(13):E743-E749

Department of Orthopedics, Trauma Surgery and Hand Unit, Helios Klinikum Krefeld, Krefeld, Germany.

Study Design: Case report and literature review.

Objective: We present a case of a pathologic unstable fracture of the odontoid process due to vertebral osseous sarcoidosis. The surgical management of this unreported pathology is described and a review of the literature is given. Read More

Ann Plast Surg 2021 Jun;86(6S Suppl 5):S628-S631

Department of Biomedical Engineering.

Introduction: Wound healing affects millions of people annually. After injury, keratinocytes from the wound edge proliferate, migrate, and differentiate to recapitulate the 3-dimensional (3D) structure needed to provide a barrier function. If the wound is too large, skin grafting may be required. Read More

Ann Plast Surg 2021 Jun;86(6S Suppl 5):S585-S592

From the Department of Plastic Surgery, University of Virginia Health System, Charlottesville, VA.

Introduction: Prepectoral acellular dermal matrix (ADM)-assisted breast reconstruction has demonstrated improved pain scores, faster return to full range of motion, and an appropriate postoperative safety profile when compared with cohorts with submuscular implant placement; however, there are limited data on aesthetic outcomes. Basic science biointegration research has previously demonstrated faster ADM incorporation with fenestrated compared with confluent ADM. We report the safety profile of anterior support meshed ADM prepectoral breast reconstruction and analyze predictive factors for aesthetic outcomes after gel implant placement. Read More

Ann Plast Surg 2021 Jun;86(6S Suppl 5):S487-S490

Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL.

Abstract: Adipose fat grafting (AFG) is a popular technique used to add volume in the face, breasts, and other tissue deficient areas of the body. In terms of scar release, not only has fat provided additional soft tissue coverage but also the relief of pain in scars in those patients suffering from disease processes, such as complex regional pain syndrome with steroid-induced atrophy, burn scars, morphea, and lupus. The purpose of this article is to demonstrate the senior author's technique and outcomes of using AFG in the face and body for treating volume deficiency, atrophic scarring, and deformities. Read More

Front Plant Sci 2021 20;12:661054. Epub 2021 May 20.

College of Agriculture, Northeast Agricultural University, Harbin, China.

Nitrate absorbed by soybean ( L. Merr.) roots from the soil can promote plant growth, while nitrate transported to nodules inhibits nodulation and nodule nitrogen fixation activity. Read More

Int Med Case Rep J 2021 28;14:361-364. Epub 2021 May 28.

Department of Ophthalmology, Nara Medical University, Nara, Japan.

Primary acquired melanosis (PAM) of the conjunctiva is a potentially serious melanocytic lesion that can lead to the development of a melanoma. A 60-year-old woman noticed pigmentation of the conjunctiva of her left eye for more than 10 years. She underwent excisional biopsy combined with cryotherapy and was diagnosed with PAM without atypia by intraoperative consultation. Read More

Anesth Essays Res 2020 Jul-Sep;14(3):536-538. Epub 2021 Mar 22.

Department of Anesthesiology, Aarupadai Veedu Medical College, Puducherry, India.

Difficult intubation in cases of post burn contracture over neck is a known problem. We report five cases of postburn contracture over neck, posted for scar excision and split skin grafting. Detailed preanesthetic examination and airway evaluation was done. Read More

Nephrol Ther 2021 Jun 1. Epub 2021 Jun 1.

Service de néphrologie, dialyse et transplantation rénale, CHU Ibn Sina, Avenue Abderrahim-Bouabid, Faculté de médecine et de pharmacie, Université Mohammed V de Rabat, impasse Souissi, 10100 Rabat, Maroc.

Microscopic polyangiitis is an ANCA-associated vasculitis and affects small sized vessels. We report a case of microscopic polyangiitis, in a 31 year old patient with renal, skin and neurologic manifestations, which was probably triggered by a selective serotonin reuptake inhibitor. Under induction therapy with corticosteroids and cyclophosphamide, the kidney recovery is complete, neurological is slow but satisfactory. Read More

Medicine (Baltimore) 2021 Jun;100(22):e26235

Department of Plastic Surgery and Hand Surgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Rationale: Degloving foot injuries are challenging to treat and associated with life-long sequelae for patients. An appropriate debridement of ischemic soft tissues with maximal preservation of glabrous skin is key during the reconstruction of these injuries. Indocyanine green (ICG) fluorescence angiography is an established technique for the intraoperative evaluation of tissue perfusion. Read More

Am J Transplant 2021 Jun;21(6):2298-2300

Department of Medicine, Section of Nephrology and Hypertension, Tulane University School of Medicine, Tulane Transplant Institute, New Orleans, Louisiana, USA.

Int Wound J 2021 Jun 3. Epub 2021 Jun 3.

Division of Vascular and Endovascular Surgery, Department of Surgery, University of Ottawa, Ottawa, Ontario, Canada.

In 2017, The Ottawa Hospital initiated a unique-in-Canada quality improvement initiative by opening a novel, multi-specialist limb-preservation clinic. We sought to describe the structure, processes, and initial outcomes of the clinic and evaluate whether it is achieving its mandate of providing high-quality wound clinical care, education, and research. We conducted a descriptive prospective cohort study alongside a nested study of 162 clinic patients requiring serial assessments. Read More

Exp Dermatol 2021 06;30 Suppl 1:18-22

European Hidradenitis Suppurativa Foundation e.V., Dessau, Germany.

The reported incidence of COVID-19 among cohorts of patients with inflammatory bowel and skin diseases under treatment with biologicals is low. Treatment may further modify disease severity as some biological modifiers, such as anakinra, are also proposed for the management of COVID-19 patients potentially providing HS patients with an advantage. The above preliminary evidence suggests that hidradenitis suppurativa (HS) does probably not provide an increased susceptibility for COVID-19 and that any susceptibility is unlikely to be modified negatively by treatment with biologicals. Read More

Exp Dermatol 2021 Jun;30 Suppl 1:8-17

European Hidradenitis Suppurativa Foundation e.V., Dessau, Germany.

The registration of the tumour necrosis factor-α inhibitor adalimumab in 2015 was a major step forward in the treatment of hidradenitis suppurativa/acne inversa (HS). However, it soon became evident that the effectiveness of adalimumab in daily practice was highly variable. A significant unmet medical need of HS patients remained, and the search for novel therapeutic targets was intensified. Read More

Aesthetic Plast Surg 2021 Jun 3. Epub 2021 Jun 3.

Division of Plastic and Reconstructive Surgery, American University of Beirut Medical Center, Beirut, Lebanon.

Background: Fat grafting has been extensively applied as natural filler and has been very promising in restoring volume loss. Lipografting has also been credited to reduce age-related skin changes due to the regenerative potential of adipose derived stem cells. Cell-mediated therapies in plastic surgery are rapidly evolving with growing applications. Read More

J Cutan Aesthet Surg 2021 Jan-Mar;14(1):129-131

Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India.

One of the measures for the successful take of a skin graft is the prevention of friction, especially in cases of pressure ulcers in patients with head injury leading to altered sensorium. With existing measures such as the use of a pressure-relieving bed, frequent change of position, etc graft loss is common. Some additional measures are required. Read More

J Cutan Aesthet Surg 2021 Jan-Mar;14(1):32-40

Department of Dermatology, Government Medical College, Amritsar, Punjab, India.

Context: Vitiligo is a common primary acquired pigmentary disorder due to loss of epidermal functioning melanocytes. Many surgical techniques have evolved over the years for its treatment and the need of a cost-effective modality has always been put forward.

Aim: The aim of the study was to compare the efficacy of non-cultured epidermal cell suspension with that of epidermal curettage in repigmentation of stable vitiligo. Read More

Facial Plast Surg 2021 Jun 3. Epub 2021 Jun 3.

Department of Otolaryngology, Manhattan Eye, Ear and Throat Institute, New York, New York.

Vascular compromise leading to cutaneous loss following surgical rhinoplasty is a devastating complication. The objective of this review is to identify all reported cases in literature published in English and summarize the current evidence to identify the patients at risk of this complication following surgery. A comprehensive literature review using Medline and Embase databases was performed to capture all reported cases of cutaneous vascular compromise following rhinoplasty from database inception through September 2020. Read More

Clin Exp Dermatol 2021 Jun 3. Epub 2021 Jun 3.

Departments of Haematology, Christian Medical College, Vellore, Tamil Nadu, India.

Background: Acute cutaneous graft versus host disease (acGVHD) following hematopoietic stem cell transplant (HSCT) is common but difficult to distinguish from other causes of rash. Plasma elafin has been proposed as a diagnostic and prognostic biomarker of skin GVHD.

Objective: A study to evaluate the role of plasma elafin as a biomarker in acGVHD in an Indian population. Read More