Search Our Scientific Publications & Authors

J Infect 2020 Jun 28. Epub 2020 Jun 28.

Surgery, and Nephrology, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Objectives: We evaluated the effectiveness of IGRA-based isoniazid (INH) treatment with the diagnostic value of quantitative IGRA titer for post-transplant tuberculosis (TB) in kidney transplant (KT) recipients.

Methods: All adult KT recipients were enrolled from January 2014 to December 2017. The development of TB after KT was observed, stratified by quantitative IGRA results as well as by IGRA results with/without INH treatment. Read More

Neurology 2020 Jun 30. Epub 2020 Jun 30.

From the MRC Centre for Neuromuscular Disease, Neuroimmunology and CSF Laboratory (S.K., O.J.Z., H.M., A.C., M.M.R., M.P.L.), Institute of Neurology, Cancer Division (D.F., J.B., A.C., K.Y., S.D.), Department of Endocrinology (F.C., S.E.B., M.P.L.), and Division of Neuropathology, National Hospital for Neurology and Neurosurgery (Z.J., S.B.), University College London NHS Foundation Trust (S.K.), National Hospital for Neurology and Neurosurgery; Department of Neuromuscular Diseases (S.K., O.J.Z., H.M., A.C., M.M.R., M.P.L.), UCL Queen Square Institute of Neurology; and Department of Clinical Neurosciences (J.F., S.R.), John Radcliffe Hospital, Oxford, UK.

Objective: POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin lesions) is a paraneoplastic disorder resulting in severe neurologic disability. Understanding the clinical, laboratory, neurophysiologic, and histopathologic features as well as treatment responses of POEMS will assist in more accurate and timely diagnosis, risk stratification, and effective management.

Methods: This was a retrospective longitudinal cohort study from 1998 to March 2019, with 7,184 person-months of follow-up time. Read More

Vascular 2020 Jul 1:1708538120937616. Epub 2020 Jul 1.

Royal Free Vascular Malformation Service, Department of Vascular Surgery, Royal Free London NHS Foundation Trust, London, UK.

Objective: The current literature on the major complications of embolo-sclerotherapy of upper and lower extremity vascular malformations is scarce. Evaluating and understanding the rates and types of potential major complications of embolo-sclerotherapy of vascular malformations help treatment planning and informed consent. Therefore, this study reviewed major complications following embolo-sclerotherapy of all upper and lower extremity vascular malformations in a single specialized multidisciplinary vascular malformation center over a 5-year period. Read More

Ren Fail 2020 Nov;42(1):607-612

Department of Nephrology & Transplantation, Beaumont Hospital, Dublin, Ireland.

Solid organ transplantation is associated with increased risk of non-melanoma skin cancer. Studies with short follow up times have suggested a reduced occurrence of these cancers in recipients treated with mammalian target of rapamycin inhibitors as maintenance immunosuppression. We aimed to describe the occurrence of skin cancers in renal and liver transplant recipients switched from calcineurin inhibitor to sirolimus-based regimes. Read More

J Craniofac Surg 2020 Jun 19. Epub 2020 Jun 19.

Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine.

Background: Fibrin sealant has been used for skin grafting in anatomically difficult facial areas. Although biodegradable, an excess of fibrin sealant may inhibit skin graft healing by inhibiting diffusion at the graft-recipient bed interface. The impact of fibrin sealant volume on graft healing was examined in a rat full-thickness skin graft model. Read More

J Craniofac Surg 2020 Jun 24. Epub 2020 Jun 24.

Body Sculpture and Liposuction Center of Plastic Surgery Hospital, Peking Union Medical College, China Academy of Medical Sciences, Beijing, China.

Objective: In Asia, the temporal hollowing is considered to be a sign of bad fortune and aging. Many people demand to correct the temporal hollowing with fat grafting. Subsequently, the temporal hypertrophy secondary to fat grafting become more and more. Read More

Liver Transpl 2020 Jun 30. Epub 2020 Jun 30.

Service d'hépatologie, Hôpital Haut Lévêque, CHU de Bordeaux, France.

Approximately 80% of patients with primary sclerosing cholangitis (PSC) also have inflammatory bowel disease (IBD). The effect of IBD on the outcomes of liver transplantation (LT) for PSC is unclear. We retrospectively collected data from adults who underwent LT for PSC from 1989 to 2017 in four French LT centers. Read More

Microsurgery 2020 Jun 30. Epub 2020 Jun 30.

Department of Plastic and Reconstructive Surgery, E-Da Hospital, Kaohsiung, Taiwan.

Background: Most skin paddles of the fibula flap are harvested from the distal third of the lower leg, skin grafting for the donor-site is necessary.

Methods: A retrospective review was done on patients with large bony defects using free fibula osteocutaneous flaps (FOSCFF) for head and neck reconstruction. We focus on the techniques for closure of donor sites were skin grafting, primary closure with tear drop design and propeller flap technique on the donor site closure using skin graft, primary closure and local propeller flap based on the different location of perforators of FOSCFF. Read More

BMJ Case Rep 2020 Jun 29;13(6). Epub 2020 Jun 29.

Plastic Surgery, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Complete penile amputation is a rare and poorly documented injury with severe physical and psychosocial implications. Our institution presents a case of successful penile replantation following 23 hours of ischaemia time in a 34-year-old man with a history of paranoid schizophrenia who sustained a complete penile amputation during an act of deliberate self-harm. To the best of our knowledge, this is the longest documented ischaemia time for a successful penile replant in literature. Read More

J Plast Reconstr Aesthet Surg 2020 May 25. Epub 2020 May 25.

Kronowitz Plastic Surgery, PLLC, Houston, TX, United States.

Background: The authors hypothesized that optimization of nipple-areolar reconstruction using full-thickness skin graft and cartilage graft can be completed safely in a single-stage procedure.

Methods: A retrospective analysis of abdominal-based flap breast reconstruction patients who underwent nipple-areolar reconstruction (NAR) using the modified double-opposing tab (mDOT) flap technique was conducted. Complication rates were compared between patients who underwent NAR in a traditional staged procedure versus a single stage. Read More

PLoS One 2020 29;15(6):e0234847. Epub 2020 Jun 29.

Department of Cardiac Surgery, Mid-German Heart Center, University Hospital Halle (Saale), Halle, Germany.

Background: The optimum risk score determining perioperative mortality and morbidity in cardiac surgery remains debated. Advanced glycation end products (AGEs) derived from glycaemic and oxidative stress accumulate to a comparable amount in skin and the cardiovascular system leading to a decline in organ function. We aimed to study the association between AGE accumulation measured as skin autofluorescence (sAF) and the outcome of cardiac surgery patients. Read More

J Clin Invest 2020 Jun 29. Epub 2020 Jun 29.

The lymph node (LN) is an intriguing site not only for inducing protective effector immunity but also for inducing tolerance against peripherally encountered antigens such as tissue-specific self-antigens that are regionally drained and through draining lymph nodes (DLNs). The dual functions of DLNs in immunity are attributable at least in part to fibroblastic reticular cells (FRCs), which are a major population of the nonhematopoietic compartment in the LN. In this issue of the JCI, Li, Zhao, and colleagues investigated DLNs in the transplantation setting. Read More

Fetal Pediatr Pathol 2020 Jun 29:1-6. Epub 2020 Jun 29.

Department of Pediatric Gastroenterology, Hepatology and Nutrition, Erciyes University Faculty of Medicine, Kayseri, Turkey.

Introduction: The coexistence of progressive familial intrahepatic cholestasis type 2, failure to thrive due to an LPIN3 mutation, and stigmata of neonatal neurofibromatosis represents a complex diagnostic challenge.

Case Report: We present a child with cholestasis requiring hepatic transplantation, explained by the progressive familial intrahepatic cholestasis type 2, failure to thrive could be contributed to by the LPIN3 mutation, and skin findings along with the family history of the patient was due to neurofibromatosis type 1.

Conclusion: Our case illustrates the complexities of multiple genetic mutations in a child. Read More

Br J Dermatol 2020 Jun 29. Epub 2020 Jun 29.

Patientforeningen HS, Copenhagen, Denmark.

The management of hidradenitis suppurativa (HS), a chronic inflammatory skin disease, deserves special consideration in the context of the Coronavirus 2019 (COVID-19) pandemic. A new Global Hidradenitis Suppurativa COVID-19 Registry has been developed to capture data on risks, clinical course, and outcomes of COVID-19 in HS patients. Caused by the virus SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2), COVID-19 is an easily transmissible disease which, in its most severe form, is characterized by respiratory failure and multiple organ dysfunction triggered by a cytokine storm response that predominates in older adults and those with significant comorbidities. Read More

Int J Bioprint 2020 21;6(1):246. Epub 2020 Jan 21.

State Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi'an Jiaotong University, Xi'an, China.

The skin is the largest human organ, and defects in the skin with a diameter greater than 4 cm do not heal without treatment. Allogeneic skin transplantation has been used to allow wound healing, but many grafts do not survive after implantation, due to multiple complications in the procedure. In the present study, the vascularization of three-dimensional (3D) printed full-thickness skin grafts was investigated. Read More

Zhonghua Shao Shang Za Zhi 2020 Jun;36(6):484-487

Department of Burns and Plastic Surgery, the Fourth Medical Center of PLA General Hospital, Beijing 100048, China.

To explore the clinical strategies for preservation of the exposed implant in chronic wounds and wound repair. From January 2016 to January 2019, totally 8 patients (4 males and 4 females, aged 10 to 73 years) sustaining postoperative chronic wounds with exposed implants were admitted to the Fourth Medical Center of PLA General Hospital. There were 2 cases of abdominal patch exposure after abdominal trauma surgery, 2 cases of titanium plate exposure post craniocerebral surgery, 3 cases of internal fixator exposure post orthopedic surgery, and 1 case of cerebrospinal fluid drainage tube exposure after craniocerebral surgery. Read More

Zhonghua Shao Shang Za Zhi 2020 Jun;36(6):446-450

Institute of Burns, Tongren Hospital of Wuhan University & Wuhan Third Hospital, Wuhan Remains (Organs) Donation Registration and Skin Receiving Station, Wuhan 430060, China.

To investigate the causes of death and etiological characteristics of skin tissue donors, and to provide reference for allogeneic skin transplantation. From October 2008 to October 2018, 49 skin tissue donors accepted by the Burn Department of Wuhan Third Hospital met the inclusion criteria of this study, and a cross-sectional study was conducted. According to the cause of death, the donors were divided into accidental death group (19 cases) and non-accidental death group (30 cases). Read More

Int Angiol 2020 Jun 25. Epub 2020 Jun 25.

Department of Vascular Disease, University Medical Centre Ljubljana, Ljubljana, Slovenia -

Critical limb ischemia represents the most severe pattern of peripheral arterial disease (PAD) associated with the high risk of major amputation, cardiovascular events and death. The diagnosis and management of critical limb ischemia (CLI) is often challenging. Systolic ankle and toe pressure measurements are considered to be the basic techniques for the identification of PAD. Read More

J Eur Acad Dermatol Venereol 2020 Jun 28. Epub 2020 Jun 28.

Dermatology Departments, Instituto Nacional de Pediatría, Mexico City, Mexico.

Griscelli syndrome type 2 (GS2) features silvery-grey hair, bronzed skin and immunodeficiency.  The only curative treatment for GS2 is haematopoietic stem cell transplantation (HSCT) which corrects the immune and haematologic defects with persistence of oculocutaneous abnormalities. Read More

J Cutan Pathol 2020 Jun 28. Epub 2020 Jun 28.

Department of Dermatology, Mayo Clinic, Rochester, Minnesota.

Acral localized acquired cutis laxa (ALACL) is a rare variant of acquired cutis laxa, and the clinical appearance is characterized by loose, redundant and wrinkled skin of the distal extremities. By definition, histology of affected tissue reveals sparse or fragmented elastic fibers. However, this can be difficult to assess on routine staining, and sometimes requires electron microscopy. Read More

J Burn Care Res 2020 Jun 28. Epub 2020 Jun 28.

Shriners Hospitals for Children Northern California and Firefighters Regional Burn Center at University of California, Davis.

Since toddlers explore with their hands, contact burns continue to be a major pediatric problem. The purpose of this report is to review our 8-year experience with contact burns of the hand. After IRB approval, a review of pediatric contact hand burns that occurred between 2006-2014 was performed. Read More

J Biomed Res 2019 Jul 31:1-8. Epub 2019 Jul 31.

Department of Pathophysiology, Nanjing Medical University, Nanjing, Jiangsu 211166,

Morphological and functional abnormalities of vascular endothelial cells (VECs) are risk factors of ischemia-reperfusion in skin flaps. Signaling pathway mediated by interleukin-1 receptor (IL-1R) is essential to hypoxia/reoxygenation (H/R) injury of VECs. While the TIR/BB-loop mimetic (AS-1) disrupts the interaction between IL-1R and myeloid differentiation primary-response protein 88 (MyD88), its role in the VECs dysfunction under H/R is unclear. Read More

Medicine (Baltimore) 2020 Jun;99(26):e20874

Department of Orthopaedics, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, Zhejiang Province.

Introduction: Idiopathic necrotizing fasciitis (NF) is an infrequent, highly lethal skin infection that spreads rapidly, marked by fascia and subcutaneous tissue necrosis. It occurs in the absence of a known causative factor. Its emergence after sterile orthopedic fixation with unexpected spread to the abdomen may turn to be challenging both as a medical and surgical emergency. Read More

J Trauma Acute Care Surg 2020 Jun 24. Epub 2020 Jun 24.

Ghent University Hospital, C. Heymanslaan 10, 9000 Ghent, Belgium.

Background: Since its introduction on the market in 2007, the number of reports on injuries caused by the overheating, ignition or explosion of electronic nicotine delivery systems (ENDS) has increased significantly. These injuries appear to have different causes, the most important one being lithium-ion battery overheating to the point of ignition or explosion.

Methods: A literature search for all relevant studies concerning ENDS related traumatic injuries of all kinds was conducted, according to the PRISMA protocol. Read More

PLoS One 2020 26;15(6):e0235266. Epub 2020 Jun 26.

Division of Plastic Surgery, Department of Trauma, Hand and Reconstructive Surgery, University Hospital Muenster, Muenster, Germany.

Background: Chronic rejection remains the Achilles heel in vascularized composite allotransplantation. Animal models to specifically study chronic rejection in vascularized composite allotransplantation do not exist so far. However, there are established rat models to study chronic rejection in solid organ transplantation such as allogeneic transplantation between the rat strains Lewis and Fischer344. Read More

Cancer Sci 2020 Jun 26. Epub 2020 Jun 26.

Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Transgenic green fluorescent protein (GFP) gene mice are widely used. And for the unique advantages of immunodeficient animals in the field of oncology research, we aim to establish a nude mouse inbred strain, which stably expresses EGFP (enhanced-GFP) for the use of transplanted tumor microenvironment (TME) research. Female C57BL/6-Tg(CAG-EGFP) mice were backcrossed with male BALB/c nude mice for eleven generations. Read More

J Cutan Pathol 2020 Jun 25. Epub 2020 Jun 25.

Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.

We report a case of differentiation syndrome in a patient receiving the IDH1 inhibitor ivosidenib, with skin biopsy showing isocitrate dehydrogenase (IDH) R132H-mutated leukemia cutis. A 72-year-old man with IDH1-mutated acute myeloid leukemia (AML), status-post allogeneic cell transplantation, on ivosidenib for six months, was admitted for culture-negative neutropenic fever, pink and purpuric plaques and patches on the legs, abdomen and back, edema, hypotension, and shortness of breath. Skin biopsy revealed an infiltrate of atypical, immature, myeloperoxidase-positive mononuclear cells compatible with leukemia cutis or Sweet syndrome. Read More

Drugs Context 2020 12;9. Epub 2020 Jun 12.

Department of Pharmacological and Biomolecular Science, University of Milano, Milan, Italy.

Approximately 95% of patients receiving radiotherapy (RT) will ultimately develop radiation-induced dermatitis (RID) during or after the course of treatment, with major consequences on quality of life and treatment outcomes. This paper reviews the pathophysiology of RID and currently used topical products for the prevention and treatment of RID. Although there is no consensus on the appropriate management, recent evidence suggests that the use of topical products supports to protect and promote tissue repair in patients with RID. Read More

BMJ Case Rep 2020 Jun 24;13(6). Epub 2020 Jun 24.

Department of Medicine, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

Varicella-zoster virus (VZV) encephalitis typically occurs in immunosuppressed populations such as in patients with HIV/AIDS, transplantation and autoimmune disease. However, it can also occur in healthy hosts. We present the case of an immunocompetent patient who presented with a clinical picture of VZV encephalitis with the sole precipitating factor of advanced age. Read More

Stem Cell Res Ther 2020 Jun 26;11(1):257. Epub 2020 Jun 26.

Stem Cell Research Laboratory (SCRL), Immunotherapy Research Center (IRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, South Korea.

Background: Schwann cells (SCs) are primarily responsible for regeneration and repair of the peripheral nervous system (PNS). Renewable and lineage-restricted SC precursors (SCPs) are considered highly desirable and promising cell sources for the production of SCs and for studies of SC lineage development, but SCPs are extremely limited. Here, we present a novel direct conversion strategy for the generation of human SCPs, capable of differentiating into functional SCs. Read More

Stem Cell Res Ther 2020 Jun 26;11(1):254. Epub 2020 Jun 26.

Hematology, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, 222 Banpodae-ro, Seocho-gu, Seoul, 06591, South Korea.

Background: Human chronic graft-versus-host disease (CGVHD) shares clinical characteristics with a murine sclerodermatous GVHD (Scl-GVHD, B10.D2 → BALB/c) model that is characterized by skin and lung fibrosis. In this study, bone marrow- or adipose tissue-derived human mesenchymal stem cells (hMSCs) were injected into the Scl-GVHD mice to address their therapeutic effect on CGVHD. Read More

Skin Res Technol 2020 Jun 25. Epub 2020 Jun 25.

Jordan Dermatology and Hair Transplantation Center, Tehran, Iran.

Background: Fractional radiofrequency (RF) has been used for skin rejuvenation and tightening by dermatologists and cosmetic surgeons in recent years.

Methods: Twenty female patients (mean age of 51.9 years) with Fitzpatrick III to VI skin phototypes who desired to undergo skin lift/tightening received six sessions of fractional microneedle RF treatment and were assessed at baseline and then 3 months after the last session for biometric characteristics using a Colorimeter, Visioface 1000D, Tewameter, Cutometer, Mexameter, and Sebumeter and a skin ultrasound imaging system to evaluate the transepidermal water loss (TEWL), skin pores, color, melanin content, erythema, sebaceous content, and thickness and density of the epidermis and dermis. Read More

Aesthetic Plast Surg 2020 Jun 24. Epub 2020 Jun 24.

Division of Plastic and Reconstructive Surgery, Department of Emergency and Organ Transplantation, University of Bari, 11, Piazza Giulio Cesare, 70124, Bari, Italy.

Large and/or ptotic breasts demonstrate significant difficulty in breast reconstruction and that the rates of perioperative complications are higher compared with the general population. The authors aim to clarify some details on their previously published technique on skin reducing mastectomy and prepectoral ADM breast reconstruction. LEVEL OF EVIDENCE V: This journal requires that authors assign a level of evidence to each article. Read More

Mol Med Rep 2020 Jun 23. Epub 2020 Jun 23.

Burns Institute, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.

Local transplantation of epidermal stem cells (ESCs) exerts a therapeutic effect on burn wounds. However, cell viability can impede their clinical application. HOX antisense intergenic RNA (HOTAIR) is involved in regulating adult tissue stem cells, as well as in developmental patterning and pluripotency. Read More

Front Cell Dev Biol 2020 9;8:437. Epub 2020 Jun 9.

Skin Regeneration, PIAS Collaborative Research, Graduate School of Pharmaceutical Science, Osaka University, Suita, Japan.

Mesenchymal stem cells (MSCs) are capable of differentiating into a limited number of diverse cells and secrete regenerative factors that contribute to the repair of damaged tissue. In response to signals emitted by tissue damage, MSCs migrate from the bone marrow and area surrounding blood vessels within tissues into the circulating blood, and accumulate at the site of damage. Hence, MSC transplantation therapy is beginning to be applied to the treatment of various intractable human diseases. Read More

Front Immunol 2020 5;11:1150. Epub 2020 Jun 5.

Department of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, Netherlands.

Mevalonate kinase deficiency (MKD) is an inborn error of metabolism leading to a syndrome characterized by recurrent inflammation. This clinically manifests itself as fever and can be accompanied by gastrointestinal symptoms, oral ulcers, cervical lymphadenopathy, and skin rash. We searched Pubmed, Embase, Cochrane, and CINAHL for relevant articles. Read More

Diagnostics (Basel) 2020 Jun 22;10(6). Epub 2020 Jun 22.

Department of Emergency and Organ Transplantation, University of Bari "Aldo Moro", Piazza G. Cesare 11, 70124 Bari, Italy.

Among all melanomas, the mucosal type is very rare and may occur in the sino-nasal mucosa, vagina, anus and the oral cavity. At variance with melanomas of the skin, no risk factors, such as familiarity, UV-exposure and skin phenotype, have been clearly identified for such neoplasms. Frequently, the diagnosis is delayed and achieved at advanced stages or when metastases have already occurred. Read More

Ann Med Surg (Lond) 2020 Aug 12;56:48-55. Epub 2020 Jun 12.

Primary Health Care, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: The objective of this study is to assess the current literature on the effectiveness of fibrin glue on survival of skin grafts. Fibrin glue is a possible alternative to secure skin grafts instead of traditional methods (i.e. Read More

Am J Dermatopathol 2020 Jun 10. Epub 2020 Jun 10.

Division of Pathology, Università degli Studi di Milano, Foundation IRCCS, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.

Skin manifestations of COVID-19 infections are diverse and are new to the dermatology community. We had the opportunity to examine the clinical and histopathological features of several patients who were divided into 3 groups. The first group included 8 COVID-19-positive patients who were hospitalized and quarantined at home. Read More

Stem Cells Transl Med 2020 Jun 23. Epub 2020 Jun 23.

Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.

Steroid-refractory chronic graft-vs-host disease (cGvHD) contributes to morbidity after allogeneic hematopoietic stem cell transplantation. Here, we report on 11 patients with severe, refractory cGvHD treated with repeated infusions of allogeneic bone marrow-derived mesenchymal stromal cells (MSC) over a 6- to 12-month period. Six patients responded to MSC treatment following National Institutes of Health response criteria, accompanied by improvement in GvHD-related symptoms and quality of life. Read More

Pediatr Transplant 2020 Jun 23:e13770. Epub 2020 Jun 23.

Pediatric Infectious Disease Research Center, Tehran University of Medical Science, Tehran, Iran.

TB is an increasing health problem, and patients undergoing HSCT are more prone to develop tuberculosis. The aim of our study was to evaluate prevalence of latent tuberculosis in HSCT recipients. In this study, 84 patients (2 months to 18 years) who were candidates for HSCT at the referral hospital of Tehran Children's Medical Center were enrolled. Read More

Zhongguo Gu Shang 2020 Jun;33(6):564-6

Department of Orthopaedics, 906 Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Ningbo 314050, Zhejiang, China.

Objective: To evaluate the effects of membrane induced by antibiotic-loaded bone cement in skin grafting for tendon exposed wound healing.

Methods: A total of 10 traumatic patients with tendon exposed wound were admitted to our department between February 2016 and December 2018, including 6 males and 4 females, with a mean age of 34.6 years old (ranged, 19 to 43 years old), and treatment duration ranged from 2 to 6 months. Read More

Int Wound J 2020 Jun 22. Epub 2020 Jun 22.

Department of Plastic and Hand Surgery, Laboratory for Tissue Engineering and Regenerative Medicine, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuernberg (FAU), Erlangen, Germany.

The purpose of this study was to analyse the outcome of our established triple treatment strategy in therapy-resistant deep-thickness chronic lower leg ulcers. This limb salvage approach consists of ultra-radical surgical debridement, negative-pressure wound therapy (NPWT) with or without instillation, and split-thickness skin grafting. Between March 2003 and December 2019, a total of 16 patients and 24 severe cases of lower leg ulcers were eligible for inclusion in this highly selective population. Read More

Transplant Proc 2020 Jun 19. Epub 2020 Jun 19.

Department of Hematology, Oncology and Internal Diseases, Medical University of Warsaw, Poland. Electronic address:

Background: Primary refractory acute myeloid leukemia (AML) is associated with dismal prognosis. No standard treatment options are available, and it remains an unmet clinical need. Here, we report a case of a tandem allogeneic hematopoietic stem cell transplantation (allo-HSCT) performed in a patient who did not achieve remission after 2 courses of induction chemotherapy. Read More

Rev Iberoam Micol 2020 Jun 19. Epub 2020 Jun 19.

Servicio de Microbiología, Hospital Universitario Central de Asturias, Fundación para la Investigación y la Innovación Biosanitaria del Principado de Asturias (FINBA), Oviedo, Asturias, España.

Background: Curvularia is a filamentous dematiaceous fungus increasingly recognized as a pathogen in immunocompromised patients. The most common clinical entities associated with this fungus are allergic sinusitis, cutaneous infection and keratitis. In this article, a report on the first clinical case of Curvularia pallescens cutaneous infection in Spain and its treatment is described. Read More

J Craniofac Surg 2020 Jun 15. Epub 2020 Jun 15.

Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.

Full-thickness defects of the calvarium often present reconstructive challenges, necessitating large rotational flaps or microsurgical free tissue transfer. Although the vascularity of the scalp is robust, there is an increased risk of wound healing complications after both direct and indirect intracranial revascularization procedures as compared to routine craniotomies, as these procedures utilize extracranial scalp vasculature to supply the ischemic brain. Patients presenting with wound healing complications following intracranial revascularization surgeries may not be candidates for extensive reconstructive procedures, as they are often medically comorbid with cardiac disease, diabetes, and a paucity of recipient vessels for free tissue transfer due to underlying vascular disease that prompts initial revascularization surgery. Read More

Ann Plast Surg 2020 Jun 17. Epub 2020 Jun 17.

From the Department of Burn and Plastic Surgery, Children's Hospital of Chongqing Medical University.

Background: The aim of the study was to present a new operative technique for aesthetic and anatomic reconstruction of polysyndactyly of the fifth toe fused with the fourth toe.

Methods: Surgery was performed in 86 feet in 73 patients with polysyndactyly of the fifth toe fused with the fourth toe. The operation involved polydactyly excision, syndactyly release using an improved dorsal asymmetric gullwing flap for web space reconstruction without skin grafting, and simultaneous correction of valgus deformity and brachydactyly of the toes. Read More

J Plast Surg Hand Surg 2020 Jun 21:1-6. Epub 2020 Jun 21.

Department of Plastic and Reconstructive Surgery, Aalborg University Hospital, Aalborg, Denmark.

Use of anticoagulants is common and practice regarding continuation or discontinuation of the medication peri-operatively for cutaneous surgery lacks evidence-based consensus. Therefore, we aimed to do a prospective observational study with patients who were referred to cutaneous surgery and needed full thickness or split skin grafting and using antitrombotic or non-antitrombotic therapies. Data on patients characteristics, diagnosis, location of surgery and surgery performed, antithrombotic medication and complications in skin grafts were collected. Read More

World J Surg 2020 Jun 22. Epub 2020 Jun 22.

HPB and Liver Transplant Unit, Department of General and Digestive Surgery, Hospital Clínic, IDIBAPS, CIBEREHD, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain.

Background: Recipient hepatectomy during liver transplantation can be a challenging operation and can increase cold ischaemic time. The aim of this study is to assess factors associated with prolonged recipient hepatectomy.

Methods: From 2005 to 2015, 930 patients were submitted to liver transplantation in our hospital. Read More

Indian J Dermatol 2020 May-Jun;65(3):217-221

Novosibirsk Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russian Federation.

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a malignancy with high frequency of skin involvement. A 39-year-old Caucasian female was suffering from weakness, myalgia, and skin eruption, which appeared during treatment of chlamydiosis with antibiotics in July 2016. Based on clinical presentation, laboratory investigations, and histological examination of skin and bone marrow biopsy, a diagnosis of BPDCN with the involvement of skin, bone marrow, and central nervous system was made. Read More