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    Non-metastatic Non-melanoma Skin Cancers: Our 3 Years of Clinical Experiences.
    World J Plast Surg 2017 Sep;6(3):305-312
    Department of Plastic, Reconstructive and Aesthetic Surgery, Faculty of Medicine, Kirikkale University Kirkkale, Turkey.
    Background: Nonmelanoma skin cancers (NMSC) constitute the largest group of skin cancers. In this study, NMSCs were analyzed retrospectively.

    Methods: Between June 2013 and March 2017, demographics and comorbidities of patients underwent reconstructive surgery for NMSC; their risk factors, types, diameters, differentiation, localizations, follow-up times, treatment methods and complications were compared and statistically analyzed. Read More

    Squamous Cell Carcinoma of Skin after 20 Years of Renal Transplantation.
    Indian J Nephrol 2017 Nov-Dec;27(6):456-458
    Department of Radiotherapy, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India.
    Solid organ transplant recipients are at high risk of developing malignancies due to the prolonged use of immunosuppressant drugs. Squamous cell carcinoma of skin can occur in these patients even after decades of organ transplant. A 45-year-old male underwent renal transplant for end-stage renal disease 23 years ago and was on immunosuppressive drugs since then. Read More

    [Study of migration and distribution of bone marrow cells transplanted animals with B16 melanoma ].
    Patol Fiziol Eksp Ter 2017 Apr-Jun;61(2):10-21
    Purpose. Reveal features migration and distribution of syngeneic bone marrow cells (BMC) and subpopulations (MSC) after transplantation into the recipient carrier B16 melanoma bodies. Methods. Read More

    PD-L1 Prevents the Development of Autoimmune Heart Disease in Graft-versus-Host Disease.
    J Immunol 2017 Dec 6. Epub 2017 Dec 6.
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520;
    Effector memory T cells (TEM) are less capable of inducing graft-versus-host disease (GVHD) compared with naive T cells (TN). Previously, in the TS1 TCR transgenic model of GVHD, wherein TS1 CD4 cells specific for a model minor histocompatibility Ag (miHA) induce GVHD in miHA-positive recipients, we found that cell-intrinsic properties of TS1 TEM reduced their GVHD potency relative to TS1 TN Posttransplant, TS1 TEM progeny expressed higher levels of PD-1 than did TS1 TN progeny, leading us to test the hypothesis that TEM induce less GVHD because of increased sensitivity to PD-ligands. In this study, we tested this hypothesis and found that indeed TS1 TEM induced more severe skin and liver GVHD in the absence of PD-ligands. Read More

    Proof of concept of a new autologous skin substitute for the treatment of deep wounds in dogs.
    Vet J 2017 Dec 7;230:36-40. Epub 2017 Nov 7.
    Department of Pharmacology, Therapeutics and Toxicology, Facultat de Veterinària, Edifici V, Universitat Autònoma de Barcelona, 08913 Bellaterra, Barcelona, Spain.
    Autologous skin grafts are effective for the repair of large skin wounds, but the availability of large amounts of skin is often limited. Through bioengineering, several autologous skin substitutes have been developed for use in human clinical practice. However, few skin substitutes are available for use in animals. Read More

    Use of a Purse-String Suture to Reduce Skin Graft Requirements.
    Ann Surg Oncol 2017 Dec 4. Epub 2017 Dec 4.
    Division of Plastic Surgery, University of North Carolina, Chapel Hill, NC, USA.
    Background: When a wound cannot be closed in a linear fashion and either a local flap or skin graft is needed, a purse-string suture can be a useful adjunct to wound closure. Local tissue architecture is maintained in cases where clear surgical margins have not been achieved at the time of extirpative skin cancer surgery. We hypothesized that this technique could be applied to a range of wound sizes and locations to avoid or reduce the need for skin grafting. Read More

    Perianal Paget's Disease-a Case Report and a Review of Current Diagnosis and Management.
    Indian J Surg Oncol 2017 Dec 1;8(4):619-621. Epub 2016 Sep 1.
    Jaslok Hospital and Lokmanya Tilak Medical College and Sion Hospital, Mumbai, India.
    Paget's disease is an intraepithelial adenocarcinoma arising from the apocrine gland component of the skin. Paget's disease is most common in the breast but extra mammary disease is also seen. Perianal Paget's disease is a rare form of extramammary disease with few cases reported in literature. Read More

    Bone Marrow-Derived Stem Cells Migrate into Intra-epidermal Skin Defects of a Desmoglein-3 knockout Mouse Model but Preserve their Mesodermal Differentiation.
    J Invest Dermatol 2017 Dec 1. Epub 2017 Dec 1.
    Eberhard Karls University, Department of Dermatology, 72076 Tübingen, Germany. Electronic address:
    Inherited forms of Epidermolysis bullosa (EB) are blistering diseases of the skin and mucosa resulting from various gene mutations. Transplantation of bone marrow (BM)-derived stem cells might be a promising systemic treatment for severe dystrophic or junctional EB, but many key questions remain unresolved. Two open questions of clinical interest are whether systemically transplanted BM-derived stem cells of mesodermal origin might be able to transdifferentiate into keratinocytes with an ectodermal phenotype and whether these cells are also capable of repairing a specific intra-epidermal gene defect. Read More

    The Helsinki Face Transplantation: Surgical aspects and 1-year outcome.
    J Plast Reconstr Aesthet Surg 2017 Nov 15. Epub 2017 Nov 15.
    Oral and Maxillofacial Surgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
    Background: Since 2005, at least 38 facial transplantations have been performed worldwide. We herein describe the surgical technique and 1-year clinical outcome in Finland's first face transplant case.

    Methods: A 34-year-old male who had a severe facial deformity following ballistic trauma in 1999 underwent facial transplantation at the Helsinki University Hospital on 8th February 2016. Read More

    Combining Adoptive Treg Transfer with Bone Marrow Transplantation for Transplantation Tolerance.
    Curr Transplant Rep 2017 4;4(4):253-261. Epub 2017 Nov 4.
    Section of Transplantation Immunology, Department of Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
    Purpose Of Review: The mixed chimerism approach is an exceptionally potent strategy for the induction of donor-specific tolerance in organ transplantation and so far the only one that was demonstrated to work in the clinical setting. Regulatory T cells (Tregs) have been shown to improve chimerism induction in experimental animal models. This review summarizes the development of innovative BMT protocols using therapeutic Treg transfer for tolerance induction. Read More

    Complete penile skin necrosis.
    Turk J Urol 2017 Dec 1;43(4):556-559. Epub 2017 Dec 1.
    Department of Urology, Adıyaman University Training and Research Hospital, Adıyaman, Turkey.
    Superficial penile skin infections may be presented in different clinical situations that vary from simple infection to organ loss and serious morbidity and mortality. Antibiotic treatment and, if necessary, urgent debridement is required. A 46-year-old male patient with the complaints of urethral discharge and pain admitted to our outpatient clinic. Read More

    Ischemic flap survival improvement by composition-selective fat grafting with novel adipose tissue derived product - stromal vascular fraction gel.
    Biochem Biophys Res Commun 2017 Nov 30. Epub 2017 Nov 30.
    Departments of Plastic Surgery, Nanfang Hospital, Southern Medical University, 1838, North Guangzhou Ave., Guangzhou, 510515, Guangdong, China.
    Background: Flap necrosis due to insufficient blood supply is a common postoperative complication in random pattern flaps. Stem cell therapies have emerged as promising biologics for tissue ischemia. A novel fat derived product, stromal vascular fraction gel (SVF-gel), can be prepared with lipoaspirate through simple mechanical processing, removing only the lipid content. Read More

    Epidemiology and Risk Factors for Cancer After Lung Transplantation.
    Transplant Proc 2017 Dec;49(10):2285-2291
    Servicio de Neumologia, Hospital Universitario Puerta Hierro, Universidad Autonoma de Madrid, Madrid, Spain.
    Cancer is the third most common cause of death among lung transplant (LT) recipients who survive for more than 1 year. The purpose of this study was to analyze the incidence and risk factors for cancer after LT in a Spanish cohort. The epidemiology and risk factors for cancer were retrospectively analyzed in LT recipients from 2 cities in Spain, Madrid and Barcelona. Read More

    Paradoxic eczema in infants after heart transplantation.
    Pediatr Dermatol 2017 Dec 1. Epub 2017 Dec 1.
    Department of Pediatric Dermatology, School of Medicine, Saint Louis University, St. Louis, MO, USA.
    New-onset psoriasis in patients receiving tumor necrosis factor inhibitors is well recognized in children and adults. We describe three children who underwent cardiac transplantation and developed an analogous form of paradoxic eczema occurring 2-48 months after starting systemic tacrolimus, a drug widely used topically to treat eczema. Anecdotal reports and our experience suggest that tacrolimus taper with alternative systemic antirejection immunosuppressant may lead to skin clearance. Read More

    Accidental sulfur mustard exposure: A case report.
    Toxicol Lett 2017 Nov 28. Epub 2017 Nov 28.
    BG Hospital Hamburg, Department of Hand Surgery, Plastic and Microsurgery, Burn Center, Bergedorfer Straße 10, 21033 Hamburg, Germany.
    The clinical progression following a sulfur mustard-induced skin exposure is well documented in the literature. Upon skin contact and a characteristic latency period, sulfur mustard (SM) causes erythema, blister formation and ulceration, which is associated with wound healing disorders that may require surgical treatment. Here, we present a case report of accidental exposure to SM in a laboratory setting which required surgical treatment of the skin. Read More

    Effect of oxytocin on the survival of random skin flaps.
    Oncotarget 2017 Nov 9;8(54):92955-92965. Epub 2017 Oct 9.
    Department of Hand Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
    Random flap transplantation is widely used to repair and rebuild skin soft tissue. However, such flaps exhibit poor survival. Plastic surgeons seek to improve flap survival. Read More

    Biomarkers of IgA vasculitis nephritis in children.
    PLoS One 2017 30;12(11):e0188718. Epub 2017 Nov 30.
    INSERM 1149, Center of Research on Inflammation (CRI), Paris, France.
    Henoch-Schönlein purpura is a systemic vasculitis characterized by IgA deposits, which target the skin, joints, and kidneys, among other organs. In children, prognosis is often good but little is known about biomarkers of pediatric nephritis. We hypothesized that biological markers, including cytokines, immunoglobulins, IgA-immune complexes, IgA glycosylation and neutrophil gelatinase-associated lipocalin (NGAL), may discriminate IgA vasculitis (IgAV) pediatric patients with renal involvement from those without renal involvement. Read More

    Mechanisms of rejection in vascular composite allotransplantation.
    Curr Opin Organ Transplant 2017 Nov 18. Epub 2017 Nov 18.
    Department of Plastic and Reconstructive Surgery, Vascularized Composite Allotransplantation (VCA) Laboratory.
    Purpose Of Review: For patients with devastating injuries in whom standard reconstruction is not an option, vascularized composite allotransplantation (VCA) has become a viable means of restoring form and function. However, immunological rejection continues to be a problem in VCA and has not yet been fully characterized. As the field is relatively new, much of the data on rejection and immunosuppression have been extrapolated from that of solid organ transplantation. Read More

    The science behind autologous fat grafting.
    Ann Med Surg (Lond) 2017 Dec 10;24:65-73. Epub 2017 Nov 10.
    Department of Medicine and Surgery, Plastic Surgery Section, University of Parma, Italy.
    Introduction: Adipose grafting has undergone significant changes over time. Many different techniques have been followed by trying to improve the quality of the lipoaspirate and the survival of the fat graft after implantation.

    Material And Methods: The purpose of this review is to analyse the historical evolution of the surgical harvesting and implant technique, describing the changes that have brought significant improvements, revolutionizing the aesthetic and functional results obtainable. Read More

    Liver Transplantation From Donors With a History of Malignancy: A Single-Center Experience.
    Transplant Direct 2017 Nov 18;3(11):e224. Epub 2017 Oct 18.
    Department of General, Visceral and Transplantation Surgery, University Hospital of Essen, University Duisburg-Essen, Essen, Germany.
    Background: The demand for transplantable organs exceeds donor organ supply. Transplantation of organs from donors with a history of malignancy remains controversial and the transmission of cancer in liver transplant recipients has not been sufficiently examined.

    Methods: From 2002 until 2017, 83 livers from donors with a history of malignancy were transplanted at the University Hospital Essen, Germany. Read More

    Parvovirus B19 in the Context of Hematopoietic Stem Cell Transplantation: Evaluating Cell Donors and Recipients.
    Transplant Direct 2017 Nov 2;3(11):e217. Epub 2017 Oct 2.
    Bone Marrow Transplantation Center (CEMO), Instituto Nacional de Câncer (INCA), Rio de Janeiro, Brazil.
    Background: Parvovirus B19 (B19V) is a common human pathogen, member of the family Parvoviridae. Typically, B19V has been found to infect erythroid progenitors and cause hematological disorders, such as anemia and aplastic crisis. However, the persistence of genomic deoxyribonucleic acid (DNA) has been demonstrated in tonsils, liver, skin, brain, synovial, and testicular tissues as well as bone marrow, for both symptomatic and asymptomatic subjects. Read More

    Cell-spray auto-grafting technology for deep partial-thickness burns: Problems and solutions during clinical implementation.
    Burns 2017 Nov 25. Epub 2017 Nov 25.
    Department of Surgery and Bioengineering, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:
    Cell-spray autografting is an innovative early treatment option for deep partial-thickness burn wounds. As an alternative to non-operative management, cell-spray autografting can achieve rapid wound re-epithelialization, particularly in large wounds. When compared to traditional mesh autografting for deep partial-thickness burn wounds, cell-spray autografting can accomplish re-epithelialization with a much smaller donor site. Read More

    Triptolide Inhibits Donor Specific Antibody Production and Attenuates Mixed Antibody-Mediated Renal Allograft Injury.
    Am J Transplant 2017 Nov 27. Epub 2017 Nov 27.
    Organ Transplantation Research Institute, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
    Donor specific antibodies (DSAs) are major mediators of renal allograft injury, and strategies to inhibit DSA are important in promoting long term graft survival. Triptolide exhibits a wide spectrum of anti-inflammatory and immuno- suppressive activities, and in autoimmune diseases it inhibits autoantibody levels. In this study, we investigated the suppressive role of triptolide in the generation of donor specific antibodies in transplant recipients. Read More

    Dermatological Complications After Solid Organ Transplantation.
    Clin Rev Allergy Immunol 2017 Nov 25. Epub 2017 Nov 25.
    Division of Gastroenterology and Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.
    Organ transplant recipients (OTRs) are a population at high risk for cutaneous adverse events. Their early recognition and appropriate treatment is an important component of the clinical management of OTRs and should be optimally dealt with by dermatologists working in the context of a transplant dermatology clinic. Skin examination should be a standard procedure before performing organ transplantation to assess conditions which may be difficult to manage after the transplant procedure has been performed or which may represent a contraindication to transplantation, e. Read More

    Grafting with Cryopreserved Amniotic Membrane versus Conservative Wound Care in Treatment of Pressure Ulcers: A Randomized Clinical Trial.
    Bull Emerg Trauma 2017 Oct;5(4):249-258
    Transplant Research Center, Shiraz Institute for Stem Cell and Regenerative Medicine, Shiraz University of Medical Science, Shiraz, Iran.
    Objective: To compare the healing process of pressure ulcers treated with cryopreserved human amniotic membrane allograft and routine pressure ulcer care in our hospital.

    Methods: From January 2012 to December 2013, in a prospective randomized clinical trial (IRCT201612041335N2), 24 patients with second and third stage of pressure ulcers were enrolled in this study. All patients needed split-thickness skin grafts for pressure ulcer-wound coverage. Read More

    [The advantages in using cyanoacrylate glue over skin staples as a method of skin graft fixation in the pediatric burns population].
    Ann Chir Plast Esthet 2017 Nov 23. Epub 2017 Nov 23.
    Service de chirurgie plastique, hôpital Saint-Joseph-Saint-Luc, 20, quai Claude-Bernard, 69007 Lyon, France.
    Introduction: Local postoperative care and burn wound management can present with a certain degree of difficulty in the pediatric population. While the use of skin staples as a method of skin graft fixation is a well-known, rapid and simple method, their removal can be painful and may necessitate some sedation or even general anesthesia. We studied in this article the advantages and economic value of using the cyanoacrylate glue as a fixation method for skin grafts. Read More

    [Ocular involvement in Stevens-Johnson syndrome: treatment with amniotic membrane transplantation in the acute phase].
    Ned Tijdschr Geneeskd 2017 ;161(0):D1739
    Universitair Medisch Centrum Groningen-Rijksuniversiteit Groningen, Groningen.
    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are both part of a spectrum of serious mucocutaneous disorders, most often caused by drugs, with a high morbidity and mortality. In the acute stage, serious skin and mucocutaneous lesions with painful blistering, erosions and systemic involvement present the main focus of attention. The severity of skin manifestations in the acute stage, however, does not necessarily correlate with that of the mucosal lesions. Read More

    Utility of superiorly based platysma myocutaneous flap for reconstruction of intraoral surgical defects: our experience.
    Oral Maxillofac Surg 2017 Nov 23. Epub 2017 Nov 23.
    Swargiya Dadasaheb Kalmegh Smruti Dental College and Hospital, Nagpur, 440024, India.
    Purpose: Various surgical modalities have been advocated for the soft tissue reconstruction of oral cavity with variable results. This prospective study evaluates the utility of platysma myocutaneous flap (PMF) in the reconstruction of surgical defects followed by treatment of oral submucous fibrosis (OSMF) and oral squamous cell carcinoma (OSCC) in terms of healing and functional outcomes.

    Methods: In this prospective study, 47 patients with OSMF and 15 of OSCC were evaluated and selected for PMF reconstruction. Read More

    Muscle fasciculation detected by ECG.
    BMJ Case Rep 2017 Nov 23;2017. Epub 2017 Nov 23.
    Medicine, University of Toronto, Toronto, Ontario, Canada.
    A 79-year-old man presented to hospital with scald burns to the perineum after a syncopal episode while in a hot bathtub. Admission ECG was misdiagnosed as possible ventricular fibrillation with high-frequency irregular waveforms in lead V2 at a rate exceeding 1000 cycles per minute, corresponding to intervening skeletal muscle contractions unrelated to the heart. Follow-up ECG showed full resolution of the irregular waveforms. Read More

    Negative Regulation of Skin Pigmentation in Three-Dimensional Reconstructs by Adipose-Derived Mesenchymal Cells.
    J Invest Dermatol 2017 Dec;137(12):2464-2466
    Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Harvard Medical School, Charlestown, Massachusetts 02129, USA. Electronic address:
    The regulation of site-specific pigmentation in reconstructs used for skin grafting is incompletely understood. Using an engineered skin equivalent model, Klar et al. incorporated adipose-derived mesenchymal cells into skin substitutes and found that adipose-derived mesenchymal cells secreted high levels of transforming growth factor-β1, which down-regulates melanogenic enzymes such as tyrosinase to decrease melanin synthesis and prevent normal pigmentation of resulting skin grafts. Read More

    Cutaneous Squamous Cell Carcinomas in Solid Organ Transplant Recipients Compared With Immunocompetent Patients.
    JAMA Dermatol 2017 Nov 22. Epub 2017 Nov 22.
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut.
    Importance: Solid organ transplant recipients (SOTRs) have a 100-fold increased risk of squamous cell carcinoma (SCC), and they may develop more aggressive SCCs compared with immunocompetent individuals.

    Objective: To compare outcomes associated with aggressive behavior of SCC in SOTRs and high-risk immunocompetent patients.

    Design, Setting, And Participants: A retrospective cohort study of 58 SOTRs and 40 immunocompetent patients evaluated at the Yale Transplant Dermatology Clinic in New Haven, Connecticut, who had at least 1 SCC confirmed histopathologically between January 1, 2008, and December 31, 2015. Read More

    A New Immunosuppressive Molecule Emodin Induces both CD4+FoxP3+ and CD8+CD122+ Regulatory T Cells and Suppresses Murine Allograft Rejection.
    Front Immunol 2017 8;8:1519. Epub 2017 Nov 8.
    Section of Immunology, Guangdong Provincial Academy of Chinese Medical Sciences, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
    Due to vigorous alloimmunity, an allograft is usually rejected without any conventional immunosuppressive treatment. However, continuous global immunosuppression may cause severe side effects, including tumors and infections. Mounting evidence has shown that cyclosporine (CsA), a common immunosuppressant used in clinic, impedes allograft tolerance by dampening regulatory T cells (Tregs), although it inhibits allograft rejection at the same time. Read More

    Route of Antigen Presentation Can Determine the Selection of Foxp3-Dependent or Foxp3-Independent Dominant Immune Tolerance.
    J Immunol 2017 Nov 22. Epub 2017 Nov 22.
    Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisbon, Portugal;
    It has been shown that dominant tolerance, namely in transplantation, requires Foxp3+ regulatory T cells. Although most tolerance-inducing regimens rely on regulatory T cells, we found that induction of tolerance to proteins in aluminum hydroxide can be achieved in Foxp3-deficient mice using nondepleting anti-CD4 Abs. This type of tolerance is Ag specific, and tolerant mice retain immune competence to respond to unrelated Ags. Read More

    Options in Acellular Dermal Matrix-Device Assembly.
    Plast Reconstr Surg 2017 Dec;140(6S Prepectoral Breast Reconstruction):39S-42S
    Warrenville, Ill. From the Institute of Aesthetic Plastic Surgery and Cantera Spa.
    Prepectoral prosthetic breast reconstruction has become increasingly popular during the last several years. Original shortcomings and poor outcomes in the 1970s have been overcome with the use of the bioengineered breast concept-namely, use of improved form stable breast implants, autologous fat grafting, and acellular dermal matrices (ADMs). Careful use of these reconstructive tools combined with improved mastectomy skin flaps has lead to successful early outcomes. Read More

    Prepectoral Immediate Direct-to-Implant Breast Reconstruction with Anterior AlloDerm Coverage.
    Plast Reconstr Surg 2017 Dec;140(6S Prepectoral Breast Reconstruction):31S-38S
    Peoria, Ill.; and Boston, Mass. From the University of Illinois College of Medicine; University of Massachusetts; and Illinois Plastic Surgery.
    Background: Staged subpectoral expander-implant breast reconstruction is widely performed. Disruption of the pectoralis major origin and the frequent occurrence of animation deformity and functional discomfort associated with subpectoral reconstruction remain ongoing concerns. Prepectoral single-stage direct-to-implant reconstruction resolves many of these issues. Read More

    Important Considerations for Performing Prepectoral Breast Reconstruction.
    Plast Reconstr Surg 2017 Dec;140(6S Prepectoral Breast Reconstruction):7S-13S
    San Francisco, Calif. From the Division of Plastic and Reconstructive Surgery, Department of Surgery, University of California, San Francisco.
    Prepectoral breast reconstruction has emerged as an excellent technique for postmastectomy reconstruction, as it allows for full preservation of a patient's pectoralis major muscle and chest wall function. This reduces pain, eliminates animation deformity, and results in high patient satisfaction. Safely performed prepectoral breast reconstruction requires a careful patient selection process before committing to the procedure, taking into account comorbidities, radiation status, and oncologic criteria such as tumor location and breast cancer stage. Read More

    [The significance of fibroblasts in experimental modeling of proliferative vitreoretinopathy].
    Vestn Oftalmol 2017 ;133(5):4-10
    Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 26 Vavilova St., Moscow, Russian Federation, 119334.
    Aim: to investigate the role of heterogeneous fibroblasts in the development of epiretinal membrane in eyes with modeled proliferative vitreoretinopathy.

    Material And Methods: The material for investigation were 6 eyes of 3 Chinchilla rabbits. Suspended fibroblasts (fibroblasts of the human skin - 200000 cells in 0. Read More

    De novo food allergy in pediatric liver transplantation recipients.
    Asian Pac J Allergy Immunol 2017 Nov 22. Epub 2017 Nov 22.
    Division of Gastroenterology Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
    Background: Food allergy (FA) prevalence is increasing in pediatric liver transplantation (LT). However, the clinical course is still limited.

    Objective: This retrospective cohort study aimed to identify the prevalence, risk factors, and the natural history of de novo FA in children post LT. Read More

    POEMS Syndrome: Therapeutic Options.
    Hematol Oncol Clin North Am 2018 Feb;32(1):141-151
    Department of Clinical Hematology, Reference Center for AL Amyloidosis, CHU, 2 Avenue ML King, Limoges 87000, France. Electronic address:
    Treatment of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome should be directed at the underlying plasma cell clone with risk-adapted therapy based on the extent of the plasma cell disorder. Radiation therapy is effective for patients with a localized presentation, without bone marrow involvement, and 1 to 3 bone lesions. Patients with disseminated disease should receive, preferably, high-dose chemotherapy with peripheral blood transplantation. Read More

    Melanoma in patients with GATA2 deficiency.
    Pigment Cell Melanoma Res 2017 Nov 20. Epub 2017 Nov 20.
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
    GATA2 deficiency is a recently described genetic disorder affecting hematopoietic stem cells and is associated with immunodeficiency, hematologic malignancy, and various cutaneous pathologies including cutaneous tumors. To explore the incidence and clinical course of melanoma in patients with germline GATA2 deficiencies, we conducted a retrospective chart review of 71 such patients and identified two with invasive melanoma. One melanoma was diagnosed early because it was associated with pruritus due to a graft-versus-tumor effect following bone marrow transplantation. Read More

    Spontaneous hair follicle germ (HFG) formation in vitro, enabling the large-scale production of HFGs for regenerative medicine.
    Biomaterials 2017 Nov 6;154:291-300. Epub 2017 Nov 6.
    Faculty of Engineering, Yokohama National University, 79-5 Tokiwadai, Hodogaya-ku, Yokohama, Kanagawa 240-8501, Japan. Electronic address:
    Hair follicle morphogenesis is triggered by reciprocal interactions between hair follicle germ (HFG) epithelial and mesenchymal layers. Here, we developed a method for large-scale preparation of HFGs in vitro via self-organization of cells. We mixed mouse epidermal and mouse/human mesenchymal cells in suspension and seeded them in microwells of a custom-designed array plate. Read More

    [Management of hypopigmented scars following burn injuries].
    Ann Chir Plast Esthet 2017 Nov 15. Epub 2017 Nov 15.
    Unité fonctionnelle de chirurgie des brûlés, service de chirurgie plastique, reconstructrice et esthétique du Pr Mimoun, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France. Electronic address:
    Objective: Permanent hypopigmentation of burn scars is a common consequence after partial and full thickness burns that heal by secondary intent, and they can cause severe aesthetic issues. The surgical goals for effective treatment of postburn hypopigmentation are to remove scar tissues, and to produce healthy melanocytes, with minimal donor site morbidity. This article reviews the current literature about the different ways to treat hypopigmentation following burn injuries and discusses the indications. Read More

    Therapeutic effects of STAT3 inhibition by nifuroxazide on murine acute graft graft-vs.-host disease: Old drug, new use.
    Mol Med Rep 2017 Dec 19;16(6):9480-9486. Epub 2017 Oct 19.
    Laboratory of Transplantation and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China.
    Graft‑vs.‑host disease (GvHD) is a major and lethal complication of allogeneic bone marrow transplantation (allo‑BMT). Although great development has been made, the treatment progress of this disorder is slow. Read More

    Toe web intertrigo in Kaposi's sarcoma patients: a microbiological study in a large cohort of patients.
    Eur J Clin Microbiol Infect Dis 2017 Nov 17. Epub 2017 Nov 17.
    Dermatology Unit, I.R.C.C.S. Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
    Kaposi 's sarcoma (KS) is a rare multifocal angioproliferative disease associated with human herpes virus 8 (HHV-8) infection, characterized by cutaneous nodules or plaques especially on the lower limbs. Some skin modifications, such as chronic lymphedema, plantar hyperkeratosis and interdigital desquamation, may be associated with consequent impairment of the local immunosurveillance and increased risk of some bacterial or mycotic infections. With the objective of evaluating if bacterial or mycotic infections in KS patients are supported by different microorganisms compared to control patients, we performed an observational retrospective study, comparing positive cultural swabs of interdigital intertrigo of KS patients with positive cultural swabs of interdigital intertrigo of patients admitted to our dermatologic unit during the last 10 years. Read More

    Body composition of Fanconi anemia patients after hematopoietic stem cell transplantation.
    Rev Bras Hematol Hemoter 2017 Oct - Dec;39(4):318-324. Epub 2017 Jul 28.
    Hospital de Clínicas da Universidade Federal do Paraná (HC/UFPR), Curitiba, PR, Brazil. Electronic address:
    Introduction: Fanconi anemia is a rare genetic disease linked to bone marrow failure; a possible treatment is hematopoietic stem cell transplantation. Changes in the nutritional status of Fanconi anemia patients are not very well known. This study aimed to characterize body composition of adult, children and adolescent patients with Fanconi anemia who were submitted to hematopoietic stem cell transplantation or not. Read More

    Oral Lymphomatoid papulosis type C: A diagnostic pitfall, often confused with T-cell lymphoma.
    Ann Diagn Pathol 2017 Dec 16;31:50-55. Epub 2017 Jun 16.
    Weill Cornell Medicine, 1300 York Ave, New York, NY 10065, USA. Electronic address:
    Eosinophilic ulcer of the oral mucosa (EUOM) is a rare, benign, self-resolving lymphoproliferative disorder, which typically presents with asymptomatic to mildly tender ulcers. Histological findings of EUOM are characterized by a polymorphic infiltrate with many eosinophils often extending into the underlying muscle. Although this entity is well documented within the dental literature, it is not well known to physicians. Read More

    Bilateral femoral posterior neurocutaneous perforater flap successfully treating Fournier gangrene: A case report.
    Medicine (Baltimore) 2017 Nov;96(46):e8720
    Department of Hand Surgery, Wuxi NO.9 People's Hospital Affiliated to Soochow University, Wuxi, China.
    Rationale: Necrotizing fasciitis (NF), characterized by widespread fascial necrosis, is a rare disease in clinic. Fournier gangrene (FG) is a special type of NF involved of perineum and scrotum. To our knowledge, no article has reported on bilateral femoral posterior neurocutaneous perforater flap treating for FG. Read More

    Induction of CD4+CD25+Foxp3+ regulatory T cells by mesenchymal stem cells is associated with RUNX complex factors.
    Immunol Res 2017 Nov 16. Epub 2017 Nov 16.
    Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
    Among the particular immunomodulation properties of mesenchymal stem cells (MSCs), one relies on their capacity to regulatory T cell (Treg) induction from effector T cells. Stable expression of Foxp3 has a dominant role in suppressive phenotype and stability of induced regulatory T cells (iTregs). How MSCs induce stable Foxp3 expression in iTregs remains unknown. Read More

    Malignancy in Renal Transplant Recipients Exposed to Cyclophosphamide Prior to Transplantation for the Treatment of Native Glomerular Disease.
    Pharmacotherapy 2017 Nov 14. Epub 2017 Nov 14.
    Department of Medicine, Division of Nephrology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
    Study Objective: To evaluate the risk of post-transplantation malignancy in renal transplant recipients exposed to pre-transplantation cyclophosphamide for treatment of glomerular nephropathy (GN).

    Design: Retrospective cohort study.

    Setting: Tertiary academic medical center. Read More

    Deferoxamine Preconditioning of Irradiated Tissue Improves Perfusion and Fat Graft Retention.
    Plast Reconstr Surg 2017 Nov 8. Epub 2017 Nov 8.
    1Hagey Laboratory for Pediatric Regenerative Medicine; Stanford University Medical Center, Stanford, CA 2Institute for Stem Cell Biology and Regenerative Medicine; Stanford University Medical Center, Stanford, CA.
    Background: Radiation therapy is a mainstay in the treatment of many malignancies, but collateral damage to surrounding tissue, with resultant hypovascularity, fibrosis, and atrophy, can be difficult to reconstruct. Fat grafting has been shown to improve the quality of irradiated skin, but volume retention of the graft is significantly decreased. Deferoxamine (DFO) is a FDA-approved iron-chelating medication for acute iron intoxication and chronic iron overload that has also been shown to increase angiogenesis. Read More

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