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    Reduction of Optic Disc Oedema by Bortezomib and Dexamethasone Followed by Autologous Peripheral Blood Stem Cell Transplantation in Patient with POEMS Syndrome.
    Neuroophthalmology 2018 Feb 19;42(1):25-30. Epub 2017 May 19.
    Department of Ophthalmology and Visual Science, Graduate School of Medicine, Chiba University, Chiba, Japan.
    The authors present findings in a 39-year-old man with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome with bilateral optic disc oedema. He was successfully treated with bortezomib and dexamethasone followed by autologous peripheral blood stem cell transplantation. The peripapillary retinal thickness was reduced in the optical coherence tomographic (OCT) images along with a decrease of the serum vascular endothelial growth factor (VEGF) levels. Read More

    Concentric Malar Lift in the Management of Lower Eyelid Rejuvenation or Retraction: A Clinical Retrospective Study on 342 Cases, 13 Years After the First Publication.
    Aesthetic Plast Surg 2018 Feb 20. Epub 2018 Feb 20.
    , 75116, Paris, France.
    Background: Lower eyelid rejuvenation can, unfortunately, induce scleral show even if the lower eyelid procedure is limited. This study was designed to assess the effectiveness and reliability of the concentric malar lift technique in two scenarios: the first, in rejuvenation of the mid-face and, the second, in reconstructive surgery for correction of congenital or acquired eyelids malposition.

    Methods: The concentric malar lift technique was first published by Le Louarn (Aesthet Plast Surg 28(6):359-372, 2004). Read More

    Suture Technique to Prevent Air Leakage during Negative-Pressure Wound Therapy in Fournier Gangrene.
    Plast Reconstr Surg Glob Open 2018 Jan 25;6(1):e1650. Epub 2018 Jan 25.
    Division of Plastic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Nursing, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Surgery, Faculty of Medicine, Collage of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; and Center for Stem Cell Research, Kaohsiung Medical University, Kaohsiung, Taiwan.
    Background: The use of negative-pressure wound therapy (NPWT) for Fournier gangrene management is well documented; however, it is difficult to fixate GranuFoam dressings and maintain an airtight seal over the perineum area. We developed a simple method to facilitate GranuFoam fixation and improve airtight sealing.

    Methods: The Fournier's gangrene severity index (FGSI) score less than 9 was collected in from January 2015 to October 2016. Read More

    Treatment Strategies for Hypopigmentation in the Context of Burn Hypertrophic Scars.
    Plast Reconstr Surg Glob Open 2018 Jan 18;6(1):e1642. Epub 2018 Jan 18.
    Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, Washington, D.C.; Firefighters' Burn and Surgical Research Laboratory, MedStar Health Research Institute, Washington, D.C.; and The Burn Center, MedStar Washington Hospital Center, Washington, D.C.
    Dyspigmentation in burn scars can contribute to the development of psychosocial complications after injury and can be detrimental to social reintegration and quality of life for burn survivors. Although treatments for skin lightening to treat hyperpigmentation have been well reviewed in the literature, skin-darkening strategies to treat hypopigmentation have not. The following potential treatment options in the context of burn hypertrophic scar will be discussed: use of the melanocyte-keratinocyte transplantation procedure, use of ectopic synthetic analogues of alpha-melanocyte stimulating hormone to initiate melanogenesis, and use of FK506 to induce melanogenesis. Read More

    Erythrodermic Psoriasis in a Man with Monoclonal B-cell Lymphocytosis.
    Cureus 2017 Dec 11;9(12):e1936. Epub 2017 Dec 11.
    Department of Dermatology, University of California, San Diego.
    Erythroderma is characterized by erythema involving greater than 90% of the body surface area and may be caused by several etiologies, including erythrodermic psoriasis. Psoriasis is an autoimmune skin and systemic condition characterized by erythematous and scaly plaques. Monoclonal B-cell lymphocytosis is an asymptomatic hematological disorder diagnosed by elevated, small, clonal B-cell counts in the peripheral blood. Read More

    Phase I study of tomuzotuximab, a glycoengineered therapeutic antibody against the epidermal growth factor receptor, in patients with advanced carcinomas.
    ESMO Open 2018 1;3(2):e000303. Epub 2018 Feb 1.
    Department of Medical Oncology, Ospedale San Raffaele, Milano, Italy.
    Background: Changes in glycosylation of the constant domain (Fc) of monoclonal antibodies (mAbs) enhance antibody-dependent cell-mediated cytotoxicity independently of downstream effects following receptor blockade by the antibody, thus extending their indication. We investigated the safety, pharmacokinetics, pharmacodynamics and antitumour activity of tomuzotuximab, an IgG1 glycoengineered mAb against the epidermal growth factor receptor with enhanced tumour cytotoxicity in a phase I dose-escalation study (NTC01222637).

    Patients And Methods: Forty-one patients with advanced solid tumours refractory to standard therapies received tomuzotuximab weekly (12-1370 mg) or two-weekly (990 mg) on a three-plus-three dose escalation design. Read More

    3D Endoscopic Donor Nephrectomy Versus Robot-Assisted Donor Nephrectomy: a Detailed Comparison of 2 Prospective Cohorts.
    Transplantation 2018 Feb 14. Epub 2018 Feb 14.
    Department of Surgery, Division of HPB and Transplant Surgery, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
    Background: There are 2 endoscopic surgical techniques that implement 3D vision to overcome visual misperception: 3D endoscopy and the da Vinci surgical system. 3D endoscopy has several advantages, such as the presence of tactile feedback and easy implementation, at lower costs. We aimed to assess whether 3D endoscopy could be an alternative to the robot during living donor nephrectomy (LDN). Read More

    Engineering principles for guiding spheroid function in the regeneration of bone, cartilage, and skin.
    Biomed Mater 2018 Feb 20. Epub 2018 Feb 20.
    Department of Biomedical Engineering, University of California - Davis, 3321 GBSF, 451 E. Health Sciences Drive, GBSF Building, Davis, CA 95616-5294, Davis, 95616, UNITED STATES.
    There is a critical need for strategies that effectively enhance cell viability and post-implantation performance in order to advance cell-based therapies. Spheroids, which are dense cellular aggregates, overcome many current limitations with transplanting individual cells. Compared to individual cells, the aggregation of cells into spheroids results in increased cell viability, together with enhanced proangiogenic, anti-inflammatory, and tissue-forming potential. Read More

    β-HPV Infection Correlates with Early Stages of Carcinogenesis in Skin Tumors and Patient-Derived Xenografts from a Kidney Transplant Recipient Cohort.
    Front Microbiol 2018 5;9:117. Epub 2018 Feb 5.
    Virology Unit, Department of Translational Medicine, Novara Medical School, University of Eastern Piedmont, Novara, Italy.
    Many malignancies that occur in high excess in kidney transplant recipients (KTRs) are due to viruses that thrive in the setting of immunosuppression. Keratinocyte carcinoma (KC), the most frequently occurring cancer type in KTR, has been associated with skin infection by human papillomavirus (HPV) from the beta genus. In this report, we extend our previous investigation aimed at identifying the presence of active β-HPV infection in skin tumors from KTRs through detection of viral protein expression. Read More

    [Clinical application of tibial composite saphenous nervetissue flap for the treatment of traumatic bone-skin defect of leg].
    Zhongguo Gu Shang 2017 Dec;30(12):1131-1134
    Department of Microsurgery and Hand Surgery, Luoyang Orthopedic Hospital of Henan Province, Zhengzhou 450008, Henan, China.
    Objective: To investigate the effect of tibial composite saphenous nerve tissue flap in repairing traumatic bone-skin defect of leg.

    Methods: From February 2009 to May 2015, 23 patients with focile skin defect caused by trauma were treated, including 18 males and 5 females, aged from 8 to 59 years old with an average age of 35.6 years old. Read More

    Blastic plasmacytoid dendritic cell neoplasm: update on therapy especially novel agents.
    Ann Hematol 2018 Feb 17. Epub 2018 Feb 17.
    Department of Hematology, The First Hospital of Jilin University, No. 71 Xinmin Street, Chaoyang District, Changchun, 130021, Jilin, People's Republic of China.
    Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematopoietic malignancy mainly affecting elderly patients. Most patients present with asymptomatic skin lesions as the first symptom and has a high frequency of bone marrow involvement. BPDCN is typically characterized by CD4+ and CD 56+ co-expression without common lymphoid or myeloid lineage markers. Read More

    Genetically-modified bone mesenchymal stem cells with TGF-βimprove wound healing and reduce scar tissue formation in a rabbit model.
    Exp Cell Res 2018 Feb 14. Epub 2018 Feb 14.
    Wake Forest Institute for Regenerative Medicine, Wake Forest University, North Carolina, USA. Electronic address:
    Extensive scar tissue formation often occurs after severe burn injury, trauma, or as one of complications after surgical intervention. Despite significant therapeutic advances, it is still a significant challenge to manage massive scar tissue formation while also promoting normal wound healing. The goal of this study was to investigate the therapeutic effect of bone mesenchymal stem cells (BMSCs) that were genetically modified to overexpress transforming growth factor-beta 3 (TGF-β), an inhibitor of myofibroblast proliferation and collagen type I deposition, on full-thickness cutaneous wound healing in a rabbit model. Read More

    Sliding free transverse rectus abdominis myocutaneous flap for closure of a massive abdominal wall defect: A case report.
    Microsurgery 2018 Feb 16. Epub 2018 Feb 16.
    Department of Hand, Plastic and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, Hand and Plastic Surgery, University of Heidelberg, Heidelberg, Germany.
    Despite considerable advances in reconstructive surgery, massive abdominal wall defects continue to pose a significant surgical challenge. We report the case of a 72-year-old morbidly obese female patient with Clostridium septicum-related gas gangrene of the abdominal wall. After multidisciplinary treatment and multiple extensive debridements, a massive full-thickness defect (40 cm × 35 cm) of the right abdominal wall was present. Read More

    Complex Infections: A Retrospective Cohort Study.
    Open Forum Infect Dis 2018 Feb 9;5(2):ofy022. Epub 2018 Feb 9.
    Division of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida.
    Background: Infections caused bygroup strains are usually resistant to multiple antimicrobials and challenging to treat worldwide. We describe the risk factors, treatment, and clinical outcomes of patients in 2 large academic medical centers in the United States.

    Methods: A retrospective cohort study of hospitalized adults with a positive culture forin Miami, Florida (January 1, 2011, to December 31, 2014). Read More

    Primary adrenal insufficiency due to hereditary apolipoprotein AI amyloidosis: endocrine involvement beyond hypogonadism.
    Amyloid 2018 Feb 15:1-4. Epub 2018 Feb 15.
    a Department of Endocrinology and Nutrition , Hospital Clínic , Barcelona , Spain.
    Several mutations in the gene encoding apolipoprotein AI (apoAI) have been described as a cause of familial amyloidosis. Individuals with apoAI-derived (AApoAI) amyloidosis frequently manifest with liver, kidney, laryngeal, skin and myocardial involvement. Although primary hypogonadism (PH) is considered almost pathognomonic of this disease, until now, primary adrenal insufficiency (PAI) has not been described as a common clinical feature. Read More

    Expanded Human Non-Cytotoxic CD8CD45RCTregs Efficiently Delay Skin Graft Rejection and GVHD in Humanized Mice.
    Front Immunol 2017 31;8:2014. Epub 2018 Jan 31.
    Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes, France.
    Both CD4and CD8Tregs play a critical role in the control of immune responses and immune tolerance; however, our understanding of CD8Tregs is limited while they are particularly promising for therapeutic application. We report here existence of highly suppressive human CD8CD45RCTregs expressing Foxp3 and producing IFNγ, IL-10, IL-34, and TGFβ to mediate their suppressive activity. We demonstrate that total CD8CD45RCTregs can be efficiently expanded in the presence of anti-CD3/28 mAbs, high-dose IL-2 and IL-15 and that such expanded Tregs efficiently delay GVHD and human skin transplantation rejection in immune humanized mice. Read More

    Various surgical techniques to create an aesthetic appearance at the donor site of anterolateral thigh free flaps based on the oblique branch: Twenty-one clinical case reports.
    Medicine (Baltimore) 2018 Feb;97(7):e9885
    Department of Plastic Surgery, Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou, People's Republic of China.
    Rationale: Reducing the morbidity associated with anterolateral thigh (ALT) donor sites by performing aesthetic restoration has become a popular research topic. Various surgical techniques have been developed allowing for direct closure of the donor site. However, closure techniques for ALT donor sites based on the oblique branch have not been systematically reported. Read More

    High-dose-rate brachytherapy in the treatment of skin Kaposi sarcoma.
    J Contemp Brachytherapy 2017 Dec 30;9(6):561-565. Epub 2017 Dec 30.
    Department of Radiation Physics, Infanta Cristina Hospital, Badajoz, Spain.
    Purpose: The aim of the study is to review our experience in treatment of Kaposi sarcoma (KS) lesions with high-dose-rate (HDR) brachytherapy.

    Material And Methods: We present five new KS lesions (three patients) that were treated in our hospital from May 2016 to February 2017 with HDR brachytherapy using Valencia applicators. The treatment was delivered in 5 Gy fractions over five sessions, on alternate days. Read More

    Botulinum toxin A increases allograft tolerance in an experimental transplantation model: A preliminary study.
    Biosci Rep 2018 Feb 13. Epub 2018 Feb 13.
    Department of Plastic and Reconstructive Surgery, CHA Bundang Medical Center, 59 Yatap-ro, Bundang-gu, Seongnam, Gyeonggi-do, 13496, Korea (South), Republic of
    Identifying novel and safe immunosuppressants is of crucial importance. Recently, there have been several studies revealing that botulinum toxin A significantly alleviates ischemia-reperfusion injuries. Emerging evidence shows that ischemia-reperfusion injuries contribute to innate immune activation, promoting rejection and inhibiting tolerance. Read More

    Long-term Scar Quality after Treatment of Standardized Partial-Thickness Skin Graft Donor Sites.
    Adv Skin Wound Care 2018 Mar;31(3):109-117
    At the University of Witten/Herdecke, Cologne-Merheim Medical Center, Cologne, Germany, Alexandra Schulz, MD, is a Consultant, Department of Plastic Surgery, Hand Surgery, Burn Center; Irene Rothermund is a Student, Department of Plastic Surgery, Hand Surgery, Burn Center; Rolf Lefering, PhD, is a Statistician, Institute for Research in Operative Medicine; Paul Christian Fuchs, PhD, is a Professor and Director, Department of Plastic, Reconstructive, Aesthetic, and Hand Surgery; and Jennifer Schiefer, MD is a Consultant, Department of Plastic Surgery, Hand Surgery, Burn Center.
    Background: The long-term aesthetic appearance of scars is of great importance to patients. Biobrane (Smith and Nephew, Fort Worth, Texas), a biosynthetic skin dressing, is a successfully established dressing for the treatment of superficial wounds. A new silk barrier dressing (Dressilk; Prevor, Moulin de Verville, France) has also shown good results in wound healing. Read More

    Multidisciplinary surgical team approach for excision of squamous cell carcinoma overlying pacemaker site.
    BMJ Case Rep 2018 Feb 6;2018. Epub 2018 Feb 6.
    Department of Cardiology, Barking, Havering and Redbridge University Hospitals Trust, Romford, UK.
    We report an unusual case of an elderly man presenting with a fast-growing large malignant tumour involving the skin overlying his permanent pacemaker site. The fast-growing cutaneous squamous cell carcinoma appeared 2 years after pacemaker implantation. Joint specialist input was required to tackle this complex problem as a wide surgical excision would expose the pacemaker generator risking device infection particularly if the skin graft reconstruction failed. Read More

    Surgical Treatment with Locoregional Flap for the Nose.
    Biomed Res Int 2017 24;2017:9750135. Epub 2017 Dec 24.
    Department of Surgery "Valdoni", Unit of Plastic and Reconstructive Surgery, "Sapienza" University of Rome, Rome, Italy.
    Nonmelanotic skin cancers (NMSCs) are the most frequent of all neoplasms and nasal pyramid represents the most common site for the presentation of such cutaneous malignancies, particularly in sun-exposed areas: ala, dorsum, and tip. Multiple options exist to restore functional and aesthetic integrity after skin loss for oncological reasons; nevertheless, the management of nasal defects can be often challenging and the best "reconstruction" is still to be found. In this study, we retrospectively reviewed a total of 310 patients who presented to our Department of Plastic and Reconstructive Surgery for postoncological nasal reconstruction between January 2011 and January 2016. Read More

    Reconstruction of Tragus and External Auditory Meatus using Remnant Auricle during Microtia Reconstruction.
    Facial Plast Surg 2018 Feb 12. Epub 2018 Feb 12.
    Department of Plastic and Cosmetic Surgery, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan Province, P.R. China.
    This article investigates an effective method with which to reconstruct the tragus and external auditory meatus for microtia reconstruction. The external ear was reconstructed using a delayed postauricular skin flap in patients with congenital microtia. After the first stage of delaying the postauricular skin flap and the second stage of otoplasty with ear framework fabricated from autogenous rib cartilage draping with the delayed skin flap, the third stage involved tragus and external auditory meatus canaloplasty. Read More

    Cellulite: A Surgical Treatment Approach.
    Aesthet Surg J 2018 Feb 8. Epub 2018 Feb 8.
    Plastic Surgery Division, Hospital São Lucas, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
    Background: Cellulite is one of the most common skin and subcutaneous tissue conditions, affecting predominantly the thighs and hips in post-adolescent women. Its etiology is not well defined, and multiple available treatments show variable efficacy.

    Objective: To describe a technique for treatment of cellulite of the gluteal region, thighs, and hips through superficial liposuction utilizing a special cannula, combined with subcutaneous autologous fat grafting. Read More

    Acute Compartment Syndrome: An Expert Survey of Orthopedic Trauma Association (OTA) Members.
    J Orthop Trauma 2018 Jan 24. Epub 2018 Jan 24.
    Louisiana State University Health Sciences Center.
    Objectives: The goal of this study was to describe current opinions of orthopedic trauma experts regarding acute compartment syndrome (ACS).

    Design: Web-based survey SETTING:: N/A PARTICIPANTS:: Active Orthopedic Trauma Association (OTA) members METHODS:: A 25 item web-based questionnaire was advertised to active members of the OTA. Using a cross-sectional survey study design, we evaluated the perceived importance of ACS, as well as preferences in diagnosis and treatment. Read More

    Pigmentation Disorders: Diagnosis and Management.
    Am Fam Physician 2017 Dec;96(12):797-804
    Norton Audobon Hospital, Louisville, KY, USA.
    Pigmentation disorders are commonly diagnosed, evaluated, and treated in primary care practices. Typical hyperpigmentation disorders include postinflammatory hyperpigmentation, melasma, solar lentigines, ephelides (freckles), and café au lait macules. These conditions are generally benign but can be distressing to patients. Read More

    Definitive Wound Closure Techniques in Fournier's Gangrene.
    Am Surg 2018 Jan;84(1):86-92
    Necrotizing soft tissue infection of the perineum, or Fournier's gangrene (FG), is a morbid and mortal diagnosis. Despite the severity of FG, the optimal definitive wound closure strategy is unknown, as are long-term wound outcomes. A retrospective review was performed over a 3-year period at a single trauma center. Read More

    Do higher cut-off values for tuberculin skin test increase the specificity and diagnostic agreement with interferon gamma release assays in immunocompromised Bacillus Calmette-Guérin vaccinated patients?
    Adv Med Sci 2018 Feb 7;63(2):237-241. Epub 2018 Feb 7.
    Ankara University School of Medicine, Department of Pulmonary Diseases, Ankara, Turkey. Electronic address:
    Purpose: Immunocompromised patients with latent tuberculosis infection (LTBI) are at high risk of progression to active tuberculosis. Detection and treatment of LTBI in this group of patients are very important to control active tuberculosis. Tuberculin skin test (TST) and interferon gamma release assays (IGRAs) are two methods for detection of LTBI. Read More

    Galectin-1 is required for the regulatory function of B cells.
    Sci Rep 2018 Feb 9;8(1):2725. Epub 2018 Feb 9.
    Division of Transplantation Immunology & Mucosal Biology, King's College London, King's Health Partners, Guy's Hospital, London, SE1 9RT, UK.
    Galectin-1 (Gal-1) is required for the development of B cells in the bone marrow (BM), however very little is known about the contribution of Gal-1 to the development of B cell regulatory function. Here, we report an important role for Gal-1 in the induction of B cells regulatory function. Mice deficient of Gal-1 (Gal-1) showed significant loss of Transitional-2 (T2) B cells, previously reported to include IL-10regulatory B cells. Read More

    [Blastic plasmacytoid dendritic cell neoplasm. Report of three cases].
    Rev Med Chil 2017 Sep;145(9):1208-1212
    Departamento de Hematología, Instituto Nacional de Cancerología, México.
    Blastic plasmacytoid dendritic cell neoplasm is a rare hematological malignancy derived from immature plasmacytoid dendritic cells. The tumor cells have an immature blastic appearance, and diagnosis is based on the expression of CD4, CD56 y CD123 in the absence of other lymphoid, natural killer, or myeloid antigens. The majority of affected individuals are older people with a mean age of 66 years. Read More

    Second Malignancies after Hematopoietic Stem Cell Transplantation.
    Curr Treat Options Oncol 2018 Feb 8;19(2). Epub 2018 Feb 8.
    The Division of Hematology and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel Hashomer, Israel.
    Opinion Statement: Second malignancies are a rare but well-defined late complication after autologous and allogeneic hematopoietic stem-cell transplantation (SCT). Solid malignancies occur in up to 15% of patients 15 years after SCT with myeloablative conditioning, with no plateau in the incidence rates. They are responsible for 5-10% of late deaths after SCT. Read More

    Surgical reconstruction of the fascia lata and posterior tibial artery perforator flap to treat children with simultaneous injury to the Achilles tendon and heel skin.
    Medicine (Baltimore) 2018 Feb;97(6):e9834
    Department of Orthopaedic Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.
    Children with simultaneous injury to the Achilles tendon and heel skin remain a challenge for clinicians. The purpose of this study is to evaluate a combined surgical procedure involving use of the fascia lata to reconstruct the Achilles tendon, and the posterior tibial artery perforator flap to cover the accompanying heel skin injury.Between February 2010 and February 2013, 8 children (3 females and 5 males) between 3 and 12 years of age, with a median age of 7. Read More

    Meek micrografting history, indications, technique, physiology and experience: a review article.
    J Wound Care 2018 Feb;27(Sup2):S12-S18
    Resident, Division of Plastic and Reconstructive Surgery, National Medical Centre 20 of November. México City, and Third Grade, Division of Plastic and Reconstructive Surgery, National Medical Centre 20 of November. México City.
    Aims: Traumatic loss of skin, particularly in major burns, requires skin grafting to repair the tissue. For a large burn, where donor sites are limited, the skin graft may need to be expanded. In addition, rapid wound closure is a large factor in successful recovery and is usually achieved by debridement and skin grafting. Read More

    Patients with Treatment-Requiring Chronic Graft versus Host Disease after Allogeneic Stem Cell Transplantation Have Altered Metabolic Profiles due to the Disease and Immunosuppressive Therapy: Potential Implication for Biomarkers.
    Front Immunol 2017 24;8:1979. Epub 2018 Jan 24.
    Section Hematology, Department of Medicine, Haukeland University Hospital, Bergen, Norway.
    Chronic graft versus host disease (cGVHD) is a common long-term complication after allogeneic hematopoietic stem cell transplantation. The objective of our study was to compare the metabolic profiles for allotransplant recipients and thereby identify metabolic characteristics of patients with treatment-requiring cGVHD. The study included 51 consecutive patients (29 men and 22 women; median age: 44 years, range: 15-66 years) transplanted with peripheral blood stem cells derived from human leukocyte antigen-matched family donors. Read More

    Factors influencing early referral, early diagnosis and management in patients with diffuse cutaneous systemic sclerosis.
    Rheumatology (Oxford) 2018 Feb 2. Epub 2018 Feb 2.
    Division of Rheumatology, University of Michigan, Ann Arbor, MI, USA.
    Objective: To gain insight into clinical practice regarding referral, early diagnosis and other aspects of the management of patients with dcSSc in Europe and the USA.

    Methods: Semi-structured interviews were conducted with 84 rheumatologists (or internal medicine physicians) and 40 dermatologists in different countries (the UK, France, Germany, Italy, Spain and the USA). Physicians were asked to identify key steps in the patient pathway relating to patient presentation, diagnosis and referral, in addition to other treatment and follow-up processes. Read More

    Gelatin-genipin-based biomaterials for skeletal muscle tissue engineering.
    J Biomed Mater Res B Appl Biomater 2018 Feb 7. Epub 2018 Feb 7.
    Department of Molecular Medicine, University of Padova, Padova, 35131, Italy.
    Skeletal muscle engineering aims at tissue reconstruction to replace muscle loss following traumatic injury or in congenital muscle defects. Skeletal muscle can be engineered by using biodegradable and biocompatible scaffolds that favor myogenic cell adhesion and subsequent tissue organization. In this study, we characterized scaffolds made of gelatin cross-linked with genipin, a natural derived cross-linking agent with low cytotoxicity and high biocompatibility, for tissue engineering of skeletal muscle. Read More

    Surgical Approach to the Thick Nasolabial Folds, Jowls and Heavy Neck-How to Approach and Suspend the Facial Ligaments.
    Facial Plast Surg 2018 Feb 6;34(1):59-65. Epub 2018 Feb 6.
    Başkent University, Istanbul Hospital, Altunizade, Istanbul, Turkey.
    Patients with thick skin typically present with a redundant, baggy, lax skin envelope together with prominent nasolabial folds, jowls, and a heavy neck. Durable and natural-appearing rejuvenation is not possible unless the deformities are addressed adequately and harmoniously in these patients. Traditional superficial musculoaponeurotic system techniques do not include surgical release of the zygomatic cutaneous ligaments and repositioning of descendent malar fat pad, and may lead to an unbalanced, unnatural appearance and the lateral sweep phenomenon. Read More

    Bioprinting of skin constructs for wound healing.
    Burns Trauma 2018 23;6. Epub 2018 Jan 23.
    1The Affiliated Hospital of Southwest Medical University, the department of Plastic & Burns Surgery, Tai Ping Street, Luzhou, 646000 People's Republic of China.
    Extensive burns and full-thickness skin wounds are difficult to repair. Autologous split-thickness skin graft (ASSG) is still used as the gold standard in the clinic. However, the shortage of donor skin tissues is a serious problem. Read More

    High-voltage electric stimulation of the donor site of skin grafts accelerates the healing process. A randomized blinded clinical trial.
    Burns 2018 Feb 2. Epub 2018 Feb 2.
    Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, São Paulo University, Ribeirão Preto, SP, Brazil; Department of Biomechanics, Medicine and Rehabilitation of the Locomotor System, Ribeirão Preto Medical School, São Paulo University, Ribeirão Preto, SP, Brazil. Electronic address:
    Introduction: Severe burns benefit from skin grafting, and grafting surgery is of great importance in the treatment of these injuries. As a result, there is formation of an additional wound at the donor site, which is painful and susceptible to infection. However, the therapeutic approach to these problems at donor sites for skin grafting is insufficiently explored in the literature. Read More

    Masculinizing Top Surgery: A Systematic Review of Techniques and Outcomes.
    Ann Plast Surg 2018 Feb 2. Epub 2018 Feb 2.
    Background: Chest wall masculinization by means of mastectomy is an important gender affirming surgery for transmasculine and non-binary patients. Limited data exist comparing commonly used techniques in masculinizing top surgery, and most are single institution studies.

    Methods: A systematic review was performed on primary literature dedicated specifically to the technical aspects and outcomes of mastectomy for masculinizing top surgery. Read More

    Primary Central Nervous System Malignant Melanoma in Children: A Case Series and Review of the Literature.
    J Pediatr Hematol Oncol 2018 Feb 2. Epub 2018 Feb 2.
    Department of Pediatrics, Division of Hematology/Oncology/Stem Cell Transplantation.
    We describe 2 cases of rapidly progressive primary central nervous system malignant melanoma, and summarize 18 previously reported cases of this extremely rare tumor in children. Both patients presented with focal neurological symptoms, with no evidence of skin or other organ system involvement. One patient was treated with temozolomide and etoposide, whereas the other was treated with multiple surgical resections, radiation therapy, and a trial of ipilimumab. Read More

    Gold thread implantation promotes hair growth in human and mice.
    Lab Anim Res 2017 Dec 31;33(4):291-297. Epub 2017 Dec 31.
    Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.
    Thread-embedding therapy has been widely applied for cosmetic purposes such as wrinkle reduction and skin tightening. Particularly, gold thread was reported to support connective tissue regeneration, but, its role in hair biology remains largely unknown due to lack of investigation. When we implanted gold thread and Happy Lift™ in human patient for facial lifting, we unexpectedly found an increase of hair regrowth in spite of no use of hair growth medications. Read More

    Intraductal papillary bile duct adenocarcinoma and gastrointestinal stromal tumor in a case of neurofibromatosis type 1.
    World J Gastroenterol 2018 Jan;24(4):537-542
    Department of Pathology, Korea University College of Medicine, Seoul 02841, South Korea.
    We report our experience with a synchronous case of gastrointestinal stromal tumor (GIST) and intraductal papillary neoplasm of the bile duct (IPNB) in an elderly woman with neurofibromatosis type 1 (NF-1). A 72-year-old woman presented with a 2-mo history of right upper abdominal pain unrelated to diet and indigestion. Fourteen years earlier, she had been diagnosed with NF-1, which manifested as café au lait spots and multiple nodules on the skin. Read More

    [Pneumatosis Cystoides Intestinalis after Hematopoietic Stem Cell Transplantation for Malignant Lymphoma - A Case Report].
    Gan To Kagaku Ryoho 2017 Nov;44(12):1402-1404
    Dept. of Surgery, Fuchu Hospital.
    A 47-year-old man underwent hematopoietic stem cell transplantation for malignant lymphoma. He developed acute skin graft versus host disease(GVHD)and pneumomycosis which were treated with steroids. One hundred and fifteen days later, the patient had a diagnosis of free gas images in the abdominal cavity and streakly air collections in the bowel wall from the ascending colon to the sigmoid colon in the CT scan. Read More

    Regeneration mechanism for skin and peripheral nerves clarified at the organ and molecular scales.
    Curr Opin Biomed Eng 2018 Jun;6:1-7
    Department of Mechanical Engineering Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
    This article is a review of current research on the mechanism of regeneration of skin and peripheral nerves based on use of collagen scaffolds, particularly the dermis regeneration template (DRT), which is widely used clinically. DRT modifies the normal wound healing process, converting it from wound closure by contraction and scar formation to closure by regeneration. DRT achieves this modification by blocking wound contraction, which spontaneously leads to cancellation of scar formation, a process secondary to contraction. Read More

    Through-and-Through Mattress Suturing Versus Tie-Over Dressing in Full-Thickness Skin Graft Reconstruction.
    Turk Arch Otorhinolaryngol 2017 Sep 16;55(3):119-124. Epub 2017 Aug 16.
    Department of Otorhinolaryngology, Princess Royal Hospital, Telford, UK.
    Objective: To compare the outcomes of securing full-thickness skin grafting (FTSG) with through-and-through mattress suturing versus the classic tie-over and pressure dressing and identify the associated risk factors of graft failure.

    Methods: A single-institution, retrospective case series of patients who had undergone excision of head and neck skin lesions requiring FTSG over a 10-year period was reviewed.

    Results: In total, 128 FTSG reconstructions were performed. Read More

    Oral candidiasis: A retrospective study of 276 Brazilian patients.
    J Oral Maxillofac Pathol 2017 Sep-Dec;21(3):351-355
    Department of Clinical, Pathology and Surgery, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
    Background: Although oral candidiasis (OC) is a very common fungal infection of oral cavity, clinical features of affected patients and their demographic profile are not well documented.

    Objective: The objective of the study was to assess the demographic profile of patients diagnosed with OC and its clinical features in an import Brazilian center of oral and maxillofacial pathology.

    Materials And Methods: A retrospective study consisted of 276 patients diagnosed with OC by cytopathology Periodic Acid-Schiff (PAS) staining, during the period of 20 years. Read More

    Using the Reversed Temporal Island Flap to Cover Small Forehead Defects from Titanium Mesh Exposure After Cranial Reconstruction.
    World Neurosurg 2018 Jan 31. Epub 2018 Jan 31.
    Maxillofacial Surgery Department 2, Department No. 16. of Plastic Surgery Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P.R. China. Electronic address:
    Background: Skin ulcers and alloplastic implant exposure are intractable complications that arise after cranial defect reconstruction. Many methods have been used to repair these defects, including skin grafting, local flaps, and free flaps; however, in most cases, alloplastic implants must be removed to control infections. Here, we describe the use of a reversed temporal island flap to repair exposed titanium mesh without removing it. Read More

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