Reduction of Optic Disc Oedema by Bortezomib and Dexamethasone Followed by Autologous Peripheral Blood Stem Cell Transplantation in Patient with POEMS Syndrome.
- Takehito Iwase,
- Hirotaka Yokouchi,
- Sonoko Misawa,
- Toshiyuki Oshitari,
- Takayuki Baba,
- Satoshi Kuwabara,
- Shuichi Yamamoto
Neuroophthalmology 2018 Feb 19;42(1):25-30. Epub 2017 May 19.
Department of Ophthalmology and Visual Science, Graduate School of Medicine, Chiba University, Chiba, Japan.
The authors present findings in a 39-year-old man with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome with bilateral optic disc oedema. He was successfully treated with bortezomib and dexamethasone followed by autologous peripheral blood stem cell transplantation. The peripapillary retinal thickness was reduced in the optical coherence tomographic (OCT) images along with a decrease of the serum vascular endothelial growth factor (VEGF) levels. Read More