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Plast Reconstr Surg 2022 Jun 28. Epub 2022 Jun 28.

Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, 1838 Guangzhou North Road, Guangzhou, Guangdong, 510515, P. R. China.

Background: Scleroderma is a chronic autoimmune disease with an incidence of 2.7 per 100,000 people. Traditional lipotransfer has been used to treat atrophic sclerotic skin. Read More

Front Immunol 2022 10;13:899975. Epub 2022 Jun 10.

Transplantation Research Center, Division of Nephrology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.

Regulatory T cells (T) have shown great promise as a means of cellular therapy in a multitude of allo- and auto-immune diseases-due in part to their immunosuppressive potency. Nevertheless, the clinical efficacy of human T in patients has been limited by their poor homeostasis. To avert apoptosis, T require stable antigenic (CD3ζ/T-cell-receptor-mediated), co-stimulatory (CD28-driven), and cytokine (IL-2-dependent) signaling. Read More

Dis Markers 2022 15;2022:8605621. Epub 2022 Jun 15.

Hepatopancreatobiliary Surgery Department 1, The Second Affiliated Hospital of Kunming Medical University, 650101 Kunming, China.

Dendritic cells (DC) initiate the immune response in the body. They can stimulate T cell activation, proliferation, and differentiation and ultimately participate in the immune response and the immune tolerance response. The purpose of this study was to coculture DCs and T cells and subcutaneously inject DCs transfected with miR-let-7i into rhesus monkey transplantations to verify the role of miR-let-7i in allograft immune tolerance. Read More

Acta Dermatovenerol Alp Pannonica Adriat 2022 Jun;31(2):79-81

Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Strongyloides stercoralis causes chronic, mostly asymptomatic infections but hyperinfection syndrome may occur in immunosuppressed patients, especially in those receiving corticosteroids. We report a case of S. stercoralis hyperinfection syndrome in a solid organ transplant recipient that occurred approximately 2. Read More

Transplant Proc 2022 Jun 22. Epub 2022 Jun 22.

Faculty of Medical Sciences, Belo Horizonte, Minas Gerais, Brazil; IMUNOLAB - Laboratory of Histocompatibility, Belo Horizonte, Minas Gerais, Brazil. Electronic address:

Background: Malignancy is a well-known complication in patients after kidney transplantation (KT), but its effect on posttransplant outcomes, allograft, and patient survival remains unexplored. The aim of this study is to report the impact of the comorbidity on clinical outcome, function, and failure of an allograft kidney.

Methods: This case-control study included 101 KT patients. Read More

PLoS One 2022 24;17(6):e0266961. Epub 2022 Jun 24.

Reproductive Medicine, Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei, China.

Uterus transplantation is a complex surgical procedure. Uterine ischemia reperfusion (I/R) injury that occurs during this process may cause a loss of function of the uterus and the failure of transplantation. Resveratrol (RSV) is a naturally occurring polyphenol found abundantly in the skin of grapes and red wine, and it has also been used as a dietary supplement in clinical practice. Read More

Transplantation 2022 Jun 24. Epub 2022 Jun 24.

Department of Urology, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan.

Background: Prophylaxis of antibody-mediated rejection (AMR) caused by donor-specific antibodies remains challenging. Given the critical roles of complement activity in antibody-mediated graft injury, we developed a lipid nanoparticle (LNP) formulation of small-interfering RNA against complement C5 (C5 siRNA-LNP) and investigated whether C5 siRNA-LNP could downregulate the complement activity and act as an effective treatment for AMR.

Methods: Lewis recipient rats were sensitized by skin grafting from Brown Norway donor rats. Read More

Immunopharmacol Immunotoxicol 2022 Jun 24:1-46. Epub 2022 Jun 24.

Department of Environmental Health and Toxicology, School of Public Health, Dalian Medical University, Dalian, Liaoning, China 116044.

Objective: To evaluate the efficacy and mechanistic bases of the intravenous injection of arsenic trioxide at clinical-relevant doses for treating imiquimod-induced psoriasis-like mouse model.

Methods: After inducing psoriasis-like skin lesions on the back of mice with imiquimod, mice in each group were injected with a clinical dose of arsenic trioxide through the tail vein. The changes in the gene expression, protein expression and distribution of relevant inflammatory factors were evaluated in the inflicted skin area, for mechanisms underlying the efficacy of intravenous AsO intervention. Read More

J Eur Acad Dermatol Venereol 2022 Jun 24. Epub 2022 Jun 24.

Department of Dermatology, University Hospital Regensburg, D-93042, Regensburg, Germany.

Background: Polymorphous light eruption (PLE) is a common, immunologically mediated, photosensitive skin disease. After ultraviolet-B (UV-B) irradiation, patients with PLE show reduced Langerhans cell (LC) depletion in the epidermis, which results in a non-suppressive microenvironment in the skin. Interestingly, severe acute graft-versus-host-disease (aGvHD) occurred in stem cell transplanted patients that showed no or incomplete depletion of LCs after UVB-irradiation. Read More

Pathogens 2022 Jun 2;11(6). Epub 2022 Jun 2.

Department of Physiology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.

Atopic dermatitis (AD) is a globally prevalent skin inflammation with a particular impact on children. Current therapies for AD are challenged by the limited armamentarium and the high heterogeneity of the disease. A novel promising therapeutic target for AD is the microbiota. Read More

J Clin Med 2022 Jun 17;11(12). Epub 2022 Jun 17.

Department of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, Pleicherwall 2, 97070 Würzburg, Germany.

Reconstruction of the donor site after radial forearm flap harvesting is a common procedure in maxillofacial plastic surgery. It is normally carried out with split-thickness or full-thickness free skin grafts. Unfortunately, free skin graft transplantation faces wound healing impairments such as necrosis, (partial) graft loss, or tendon exposure. Read More

J Clin Med 2022 Jun 11;11(12). Epub 2022 Jun 11.

Dermatology Clinic, Maggiore Hospital, University of Trieste, 34125 Trieste, Italy.

Background: Non-melanoma skin cancer (NMSC) stands as an umbrella term for common cutaneous malignancies, including basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), together with rarer cutaneous cancers, such as Merkel cell carcinoma (MCC) and other forms of adnexal cancers. The majority of NMSCs can be successfully treated with surgery or radiotherapy, but advanced and metastatic stages may require systemic approaches such as immunotherapy with immune checkpoint inhibitors (ICIs).

Summary: Since immunotherapy is not effective in all patients and can potentially lead to severe adverse effects, an important clinical question is how to properly identify those who could be suitable candidates for this therapeutic choice. Read More

J Clin Med 2022 Jun 9;11(12). Epub 2022 Jun 9.

Department of Plastic and Hand Surgery, Centre Hospitalier Universitaire Vaudois (CHUV), Rue du Bugnon 46, 1011 Lausanne, Switzerland.

Lower limb skin defects are very common and can result from a wide range of aetiologies. Split thickness skin graft (STSG) is a widely used method to address these problems. The role of postoperative dressing is primary as it permits one to apply a uniform pressure over the grafted area and promote adherence. Read More

Biomedicines 2022 Jun 19;10(6). Epub 2022 Jun 19.

Cell Production and Tissue Engineering Unit, Virgen de las Nieves University Hospital, 18014 Granada, Spain.

Bioengineered autologous skin substitutes (BASS) technology is an emerging field for skin burn therapy. However, further studies on BASS characterization, viability against standard procedures for wound healing, and protocol optimization are necessary for the improvement of BASS technology for clinical use. The aim of this study is to evaluate the effect of common antiseptics for clinical use in BASS, focusing on cell viability, inflammatory cytokine pattern, and epithelium and skin barrier integrity, in order to establish the most adequate treatment for wound care after BASS grafting. Read More

J Immunother Cancer 2022 Jun;10(6)

Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

Background: Adoptive cell therapy using cytotoxic lymphocytes is an efficient immunotherapy against solid and hematological cancers. However, elevated levels of reactive oxygen species (ROS) in the hostile tumor microenvironment can impair NK cell and T cell function. Auranofin, a gold (I)-containing phosphine compound, is a strong activator of the transcription factor Nrf2. Read More

Ned Tijdschr Geneeskd 2022 May 12;166. Epub 2022 May 12.

Admiraal de Ruyter Ziekenhuis, afd. Plastische Chirurgie, Goes.

Medical tattooing is mostly known as a treatment option after breast reconstructive surgery. Nowadays, medical tattooing has a broader indication and can be used for treating port wine stains, scars, burns and transplanted skin. We present three patients with different indications for medical tattooing: one patient with a facial port wine stain, one patient with a scar after a thoracotomy, and a patient with a skin transplantation. Read More

Clin Anat 2022 Jun 23. Epub 2022 Jun 23.

Laboratory of Basic Medicine, The 900th Hospital of PLA, Fuzhou, P.R. China.

Introduction: Dorsal hand defects accompanied by exposure of bones and tendons remain a huge challenge for plastic surgeons. The pedicled perforator flaps have unique advantages in resurfacing the defects. This study aimed to investigate the clinical efficacy of the sequential posterior interosseous artery perforator flap for repairing dorsal hand defects. Read More

J Mol Histol 2022 Jun 22. Epub 2022 Jun 22.

Department of Science and Technology, Hunan Academy of Chinese Medicine, Changsha, 410000, Hunan, China.

We investigate the protective effect of ginsenoside Rb3 on skin flap microvasculature following ischemia-reperfusion (I/R) injury and its regulatory mechanism. We used a rat model of I/R injury with the right iliolumbar artery and oxidative stress model of human dermal microvascular endothelial cells. The effects of Rb3 on skin flap tissue and endothelial cell survival, STING-IRF3 pathway activation, and endothelial cell adhesion were measured. Read More

Eur J Cancer 2022 Jun 19;171:203-231. Epub 2022 Jun 19.

Universite' de Paris, INSERM U976, AP-HP, Dermatology Department, Saint Louis Hospital, Paris, France. Electronic address:

Merkel cell carcinoma (MCC) is a rare skin cancer, accounting for less than 1% of all cutaneous malignancies. It is found predominantly in white populations and risk factors include advanced age, ultraviolet exposure, male sex, immunosuppression, such as AIDS/HIV infection, haematological malignancies or solid organ transplantation, and Merkel cell polyomavirus infection. MCC is an aggressive tumour with 26% of cases presenting lymph node involvement at diagnosis and 8% with distant metastases. Read More

J Pediatr Hematol Oncol Nurs 2022 Jun 21:275275302110560011074261. Epub 2022 Jun 21.

University of Pittsburgh and a Clinical Education Specialist at UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.

Skin breakdown occurring around central line dressings increases the risk for infection and bacteremia in all patients. The risk is magnified when experienced in pediatric patients receiving marrow-ablative therapy. A staff nurse on an inpatient pediatric oncology and bone marrow transplant unit noted an increased incidence of skin breakdown around central line dressings in patients receiving Thiotepa prior to bone marrow transplantation. Read More

Pediatr Dermatol 2022 Jun 21. Epub 2022 Jun 21.

Department of Dermatology, University of California San Francisco School of Medicine, San Francisco, California, USA.

Background/objectives: Complications of hematopoietic stem cell transplant (HSCT) include acute graft-versus-host disease (aGVHD). Severe cutaneous aGVHD can present with generalized erythroderma, desquamation, and bullae which can mimic toxic epidermal necrolysis (TEN). TEN occurs in response to a culprit medication. Read More

Clin Chim Acta 2022 Jun 18. Epub 2022 Jun 18.

Institute of Genome Research, Vietnam Academy of Science and Technology; Graduate University of Science and Technology, Vietnam Academy of Science and Technology. Electronic address:

Background: Chronic granulomatous disease (CGD) is a rare primary immunodeficiency disorder (PID) due to genetic defects in the NADPH oxidase of phagocytes. Affected patients become susceptible to infections such as pneumonia, diarrhea, and skin ulcer types. The patients require life-long treatment with prophylactic antibiotics, antifungals, or hematopoietic stem cell transplantation (HSCT) therapy. Read More

J Craniofac Surg 2022 May;33(3):935-938

Division of Plastic and Reconstructive Surgery, MUHC, McGill University, Montreal, QC, Canada.

Abstract: Patients treated for complex oncological calvarial defects are at a higher risk of severe complications (38%): infection, meningitis, dehiscence, and hardware/brain exposure. The patient cohorts at our center have led to the development of the "U-Turn" technical (UTT) addition of our previously reported turnover "tournedos" myocutaneous latissimus dorsi free flap. This allows for an improved ability to fill these large, round, complex defects, maintaining the safety of our original surgical technique, while improving aesthetic outcomes. Read More

J Craniofac Surg 2022 May 1;33(3):931-934. Epub 2021 Oct 1.

Department of Plastic and Reconstructive Surgery, College of Medicine, Hanyang University, Seoul, South Korea.

Background: Resurfacing of facial and neck defects is challenging due to the unique skin color, texture, and thickness of the region. With the development of microsurgical reconstruction, perforator- free flaps can provide adequate soft tissue. However, despite various modifications, such flaps hardly satisfy cosmetic requirements, due to differences in color and bulkiness. Read More

J Craniofac Surg 2022 May 3;33(3):910-912. Epub 2021 Aug 3.

Department of Neurosurgery and Gamma Knife Radiosurgery.

Background: Late-onset, extracranial soft tissues dehiscence in the spheno-temporal region after major neurosurgical procedures might represent a potentially life-threatening complication.Due to surgery-related galeal/pericranial and myofascial temporal atrophy, classical regional flaps are often unavailable, enforcing potential indication for free vascularized flaps.Nevertheless, in elderly multioperated patients, who are not eligible for major surgery, it becomes mandatory to consider less invasive options for reconstruction. Read More

J Craniofac Surg 2022 May 26;33(3):892-894. Epub 2021 Oct 26.

Ningbo City First Hospital, Ningbo, China.

Background: Large benign and malignant tumors in the scalp cannot be sutured directly after resection. Instead, skin grafting or skin flap repair is the most commonly used techniques. Local tissue depression and lack of hair growth are some of the drawbacks associated with these techniques. Read More

Animal Model Exp Med 2022 Jun 20. Epub 2022 Jun 20.

Department of Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Severely immunocompromised NOD.Cg-Prkdc Il2rg (NOG) mice are among the ideal animal recipients for generation of human cancer models. Transplantation of human solid tumors having abundant tumor-infiltrating lymphocytes (TILs) can induce xenogeneic graft-versus-host disease (xGvHD) following engraftment and expansion of the TILs inside the animal body. Read More

Burns 2022 Jun 9. Epub 2022 Jun 9.

Department of Diabetology, ASST Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore 3, 20162 Milan, Italy.

Skin allografts represent a milestone in burn patient treatment. However, skin procurement is still burdened by high rates of contamination, and validation procedures have not yet been standardized. In addition, it is not clear if tissue viability affects allograft skin outcomes. Read More

Sci Rep 2022 Jun 20;12(1):10322. Epub 2022 Jun 20.

Department of Human Structure and Repair, Ghent University, Ghent, Belgium.

Recent research on normal human tissues identified omnipresent clones of cells, driven by somatic mutations known to be responsible for carcinogenesis (e.g., in TP53 or NOTCH1). Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Jun;57(6):718-723

Department of Otolaryngology, Guangdong Province Hospital of Integrated Traditional Chinese and Western Medicine, Foshan 528200, China.

To investigate the method and efficacy of reconstruction of facial skin defects after removing the lesions by applying the V-Y subcutaneous pedicle flap. A retrospective analysis was performed on 23 patients with facial reconstruction by using V-Y subcutaneous pedicle flap in the Otolaryngology Department of Guangdong Integrated Traditional Chinese and Western Medicine Hospital from March 2012 to April 2021. Patient ages ranged from 45 to 85 years old, with a mean age of 66. Read More