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    Safe Administration of An Anti-PD-1 Antibody to Kidney-transplant Patients: 2 Clinical Cases and Review of the Literature.
    J Immunother 2017 Nov/Dec;40(9):341-344
    *Department of Dermatology and National Center for Tumor Diseases (NCT) ‡Department of Nephrology, University Hospital Heidelberg, Heidelberg †Department of Dermatology and Allergy, Hannover Medical School, Skin Cancer Center, Hannover, Germany.
    Antiprogrammed cell-death protein 1 (PD-1) antibodies have revolutionized therapy of metastatic melanoma and other tumors, but some subgroups of patients such as immunosuppressed patients after solid-organ transplantation, have regularly been excluded from clinical studies. We report 2 cases of kidney-transplant patients who received an anti-PD-1 antibody to treat metastatic melanoma. Treatment was tolerated well with no relevant adverse events and stable kidney functions, but the melanoma progressed in both patients. Read More

    Individualized Biventricular Epicardial Augmentation Technology in a Drug-Induced Porcine Failing Heart Model.
    ASAIO J 2017 Oct 12. Epub 2017 Oct 12.
    From the *Mechanics and High Performance Computing Group, Technical University of Munich, Garching, Germany; †Institut für Anästhesiologische Pathophysiologie und Verfahrensentwicklung, Universitätsklinikum Ulm, Ulm, Germany; †AdjuCor GmbH, Garching, Germany; §Klinik für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Ulm, Ulm, Germany; ¶Institute for Cardiovascular Prevention (IPEK), LMU, Munich, Germany; ‖I. Medizinische Klinik, Klinikum Rechts der Isar, TUM, Munich, Germany; #DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany; and **Klinik für Anästhesiologie, Universitätsklinikum Ulm, Ulm, Germany.
    For treatment of advanced heart failure, current strategies include cardiac transplantation or blood-contacting pump technology associated with complications, including stroke and bleeding. This study investigated an individualized biventricular epicardial augmentation technology in a drug-induced porcine failing heart model. A total of 11 pigs were used, for the assessment of hemodynamics and cardiac function under various conditions of support pressures and support durations (n = 4), to assess device positioning and function by in vivo computer tomographic imaging (n = 3) and to investigate a minimally invasive implantation on the beating heart (n = 4). Read More

    The Keystone Flap-A Case Series Demonstrating Practical Design, Use, and Applications.
    Plast Surg (Oakv) 2017 Aug 25;25(3):184-187. Epub 2017 Jul 25.
    Division of Plastic Surgery, Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada.
    Introduction: The keystone design perforator island flap is a trapezoidal-shaped random perforator island flap with many advantages over primary closure, skin grafting, and other local flaps for soft tissue reconstruction commonly encountered with cancer excisions.

    Methods: This case series of 39 keystone flaps in 37 patients reviews the practical design, use, and applications of the flap while highlighting certain important considerations. Keystone flaps were designed as in the original description, with a minor modification in the lower extremity where a higher flap to defect width ratio was used. Read More

    [Brentuximab vedotin treatment in patients with relapsed or refractory Hodgkin lymphoma. A Hungarian retrospective study].
    Orv Hetil 2017 Oct;158(41):1630-1634
    Belgyógyászati Intézet, Hematológiai Tanszék, Debreceni Egyetem, Általános Orvostudományi Kar Debrecen, Nagyerdei krt. 98., 4032.
    Introduction: The treatment of relapsed or refractory Hodgkin lymphoma is still a major therapeutic challenge. The use of brentuximab vedotin, an anti-CD30 antibody-drug conjugate, represents a promising approach for these patients, however clinical outcomes have not yet been evaluated in Hungary.

    Aim: Our aim was to assess the efficacy, safety and outcome of brentuximab vedotin treatment in Hungarian Hodgkin lymphoma patients. Read More

    Assisted Salvage of Ischemic Fasciocutaneous Flap Using Adipose-Derived Mesenchymal Stem Cells: In-Situ Revascularization.
    Aesthet Surg J 2017 07;37(suppl_3):S38-S45
    Private practice, Managua, Nicaragua.
    Adipose-derived mesenchymal stem cells (ASCs) have been shown to produce vascular endothelial growth factor (VEGF) and can increase perfusion in patients with critical limb ischemia. We will show that this concept can be applied to augment blood flow in zones of flap ischemia. We presented a case study of a 26-year-old man with a complex hand injury covered by a reverse radial perforator fasciocutaneous flap, which developed ischemic necrosis and was treated by debridement, transplantation of ASCs to enhance vascular support, and saline dressings. Read More

    Management of split skin graft donor site in the West African sub region: survey of plastic surgeons' practice.
    Ann Burns Fire Disasters 2017 Jun;30(2):146-149
    Department of Surgery, College of Medicine, University of Ibadan, Nigeria.
    Split skin graft (SSG) is one of the most commonly performed operations on any Plastic Surgery service. Rate of donor site healing is affected by various factors including the type of dressing applied. The aim of this study was to survey the practice of plastic surgeons in the sub region with respect to management of SSG donor site and see how it conforms to international standards. Read More

    Epidemiological profile and treatment of substance losses by trauma to the lower limbs.
    Rev Col Bras Cir 2017 Sep-Oct;44(5):444-451
    - North Wing Regional Hospital, Plastic Surgery Service, Brasília, DF, Brazil.
    Objectives: to evaluate the epidemiological profile, the surgical treatment and the postoperative results of patients with complex traumatic injuries to the lower limbs.

    Methods: we conducted a retrospective study of patients with traumatic complex injuries treated by the Plastic Surgery Service of a regional hospital in Brasília. We analyzed clinical-epidemiological data, type of surgical procedure and functional recovery of the limb after six months of treatment. Read More

    Efficacy of Conventional and Liposomal Povidone-Iodine in Infected Mesh Skin Grafts: An Exploratory Study.
    Infect Dis Ther 2017 Oct 10. Epub 2017 Oct 10.
    Mundipharma Research GmbH & Co KG, Limburg, Germany.
    Introduction: Infection is a major threat to wound healing and a leading cause of graft loss in patients undergoing meshed skin grafts (MSGs). Therefore, topical antisepsis is important in the overall treatment scheme.

    Methods: An exploratory satellite group of 14 patients with infected MSGs were enrolled as part of a prospective, randomized, controlled, parallel-group, open-label, pilot Phase II study that investigated the efficacy and tolerability of 3% liposomal povidone-iodine hydrogel (PVP-ILH, Repithel(®); RepiGel(®)) versus chlorhexidine gauze in non-infected MSGs. Read More

    Surgical Treatment of Acquired Atresia of the External Auditory Ear Canal.
    Int Arch Otorhinolaryngol 2017 Oct 28;21(4):343-346. Epub 2017 Feb 28.
    Department of ENT, European Institute for ORL, Wilrijk, Antwerp, Belgium.
    Introduction  Acquired atresia of the external auditory canal is characterized by the formation of fibrous tissue in the medial part. The causes include chronic otitis externa, perforated chronic otitis media, postoperative or idiopathic healing problems. Acquired atresia presents with hearing loss and can be associated with otorrhea. Read More

    Subcutaneous phaeohyphomycosis in kidney transplant recipients: A series of seven cases.
    Transpl Infect Dis 2017 Oct 9. Epub 2017 Oct 9.
    Department of Nephrology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
    Background: Superficial and deep fungal infections are more frequent in transplant recipients primarily because of the failure of cell-mediated immunity and lesser amount of antigen-presenting Langerhans cells in their epidermis. Here we report seven cases of post-renal transplant subcutaneous phaeohyphomycosis, all of which manifested within 1 year after transplantation and were unresponsive to prolonged courses of itraconazole. This is the first case series, to our knowledge, of phaeohyphomycosis in transplant recipients in India. Read More

    Epidemiology of keratinocyte carcinomas after organ transplantation.
    Br J Dermatol 2017 Oct 10. Epub 2017 Oct 10.
    QIMR Berghofer Medical Research Institute, Queensland, Australia.
    Keratinocyte carcinoma (KC) is the most common type of cancer among white populations, but it is even more common among solid organ transplant recipients (OTRs). The most frequent histological type of KC among OTRs is cutaneous squamous cell carcinoma (cSCC), followed by basal cell carcinoma, although the reverse is seen in the general population. Metastatic cSCCs are more frequent, and mortality is increased compared with immunocompetent populations. Read More

    [A Case of Secondary Extramammary Paget's Disease Aroundthe Cutaneous Stoma after Radical Cystectomy].
    Hinyokika Kiyo 2017 Sep;63(9):381-386
    The Department of Urology, Osaka Red Cross Hospital.
    We present a case of secondary extramammary Paget's disease around the cutaneous ureterostomy stoma after radical cystectomy. An 85-year-old man with bacillus calmette-guérin refractory high-grade urothelial carcinoma underwent radical cystectomy and cutaneous ureterostomy construction. After right ureter cancer diagnosis, he underwent right nephroureterectomy 3 years after the cystectomy. Read More

    Long-term consequences of renal insufficiency in children: lessons learned from the Dutch LERIC study.
    Nephrol Dial Transplant 2017 Jul 7. Epub 2017 Jul 7.
    Department of Medical Informatics, Academic Medical Centre, Amsterdam, The Netherlands.
    Few data exist on the prospects in adulthood for children on chronic renal replacement therapy (RRT). This article summarizes the results of a comprehensive Dutch long-term follow-up study performed in 2000 and 2010 of patients with RRT onset at age <15 years between 1972 and 1992. After a median of 25. Read More

    Suprafascial versus traditional harvesting technique for free antero lateral thigh flap: A case-control study to assess the best functional and aesthetic result in extremity reconstruction.
    Microsurgery 2017 Oct 9. Epub 2017 Oct 9.
    Department of Plastic and Reconstructive Surgery, China Medical University Hospital, Taichung, 40447, Taiwan.
    Clinical applications of ALT flap have currently extended to extremity (hand and foot) as well as oral cavity reconstruction. In these anatomical areas, the traditional harvesting technique presents a few disadvantages such as bulkiness of the recipient site and potential donor site morbidity including damage to the deep fascia and skin graft adhesions. The purpose of the present study was to compare the functional and aesthetic outcomes of upper and lower extremity reconstruction with either suprafascial or subfascial harvested anterolateral (ALT) flaps. Read More

    An Inhibitor of Thyroid Hormone Synthesis Protects Tail Skin Grafts Transplanted to Syngenic Adult Frogs.
    Zoolog Sci 2017 Oct;34(5):414-418
    Division of Embryology, Amphibian Research Center, Hiroshima University, Higashihiroshima 739-8526, Japan.
    Tail regression in amphibian tadpoles during metamorphosis is one of the most dynamic morphological changes in animal development and is induced by thyroid hormone (TH). It has been proposed that tail resorption is driven by immunological rejection in Xenopus laevis, based on experimental evidence showing that larval skin grafts become atrophic on syngenic recipient adult frogs. This led to the hypothesis that tail regression is induced by an immunological rejection against larval skin-specific antigens called Ouro proteins. Read More

    Hand rejuvenation with fat grafting: A 12-year single-surgeon experience.
    Eur J Plast Surg 2017 18;40(5):457-464. Epub 2017 Jul 18.
    Administration, ACEIP (European Surgical Association of Prof. Ivo Pitanguy Alumni), Rome, Italy.
    Background: Fat grafting has been successfully used for reconstructive and esthetic surgery of the breast, face, and other body parts. In this article, we present our protocol for hand fat grafting and over a decade of clinical experience.

    Methods: Fat tissue is obtained from the flanks, peri-umbilical region, or internal side of the thigh or knee. Read More

    Engineering fibrin hydrogels to promote the wound healing potential of mesenchymal stem cell spheroids.
    Acta Biomater 2017 Oct 5. Epub 2017 Oct 5.
    Department of Biomedical Engineering, University of California, Davis, Davis, CA 95616, USA; Department of Orthopaedic Surgery, UC Davis Health, Sacramento, CA 95817, USA. Electronic address:
    Mesenchymal stem cells (MSCs) secrete endogenous factors such as vascular endothelial growth factor (VEGF) and prostaglandin E2 (PGE2) that promote angiogenesis, modulate the inflammatory microenvironment, and stimulate wound repair, and MSC spheroids secrete more trophic factors than dissociated, individual MSCs. Compared to injection of cells alone, transplantation of MSCs in a biomaterial can enhance their wound healing potential by localizing cells at the defect site and upregulating trophic factor secretion. To capitalize on the therapeutic potential of spheroids, we engineered a fibrin gel delivery vehicle to simultaneously enhance the proangiogenic and anti-inflammatory potential of entrapped human MSC spheroids. Read More

    Intra-graft injection of tacrolimus promotes survival of vascularized composite allotransplantation.
    J Surg Res 2017 Oct 10;218:49-57. Epub 2017 Jun 10.
    Department of Plastic, Reconstructive, and Hand Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department of Clinical Research, University of Bern, Bern, Switzerland. Electronic address:
    Background: Immunosuppressive therapies derived from solid organ transplantation are effective in promoting survival of vascularized composite allotransplantation (VCA), but they cause serious side effects that are difficult to justify for this non-life-saving procedure. Unlike solid organ transplantation, hand and face transplants offer the possibility of site-specific immunosuppression for reducing systemic exposure while increasing intra-graft concentrations of the drug. Therefore, in this study, we tested whether a single intra-graft injection tacrolimus could promote VCA survival. Read More

    Interfacial Chemistry Regulation via a Skin-Grafting Strategy Enables High-Performance Lithium-Metal Batteries.
    J Am Chem Soc 2017 Oct 10. Epub 2017 Oct 10.
    Department of Mechanical and Nuclear Engineering, The Pennsylvania State University , University Park, Pennsylvania 16802, United States.
    The lithium (Li) metal anode suffers severe interfacial instability from its high reactivity toward liquid electrolytes, especially carbonate-based electrolytes, resulting in poor electrochemical performance of batteries that use 4 V high-capacity cathodes. We report a new skin-grafting strategy that stabilizes the Li metal-liquid electrolyte interface by coating the Li metal surface with poly((N-2,2-dimethyl-1,3-dioxolane-4-methyl)-5-norbornene-exo-2,3-dicarboximide), a chemically and electrochemically active polymer layer. This layer, composed of cyclic ether groups with a stiff polycyclic main chain, serves as a grafted polymer skin on the Li metal anode not only to incorporate ether-based polymeric components into the solid-electrolyte interphase (SEI) but also to accommodate Li deposition/dissolution under the skin in a dendrite/moss-free manner. Read More

    The GBAP1 pseudogene acts as a ceRNA for the glucocerebrosidase gene GBA by sponging miR-22-3p.
    Sci Rep 2017 Oct 5;7(1):12702. Epub 2017 Oct 5.
    Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, 20090, Italy.
    Mutations in the GBA gene, encoding lysosomal glucocerebrosidase, represent the major predisposing factor for Parkinson's disease (PD), and modulation of the glucocerebrosidase activity is an emerging PD therapy. However, little is known about mechanisms regulating GBA expression. We explored the existence of a regulatory network involving GBA, its expressed pseudogene GBAP1, and microRNAs. Read More

    Retroperitoneal Compartment Syndrome in Renal Transplantation: How to Salvage the Graft?
    Urology 2017 Sep 19;107:268. Epub 2017 May 19.
    Multi-organ Transplant Program, London Health Science Centre, London, Ontario, Canada; Division of Urology, Department of Surgery, London Health Science Centre, London, Ontario, Canada.
    Objective: Early allograft dysfunction may be caused by several technical factors including vascular complications such as thrombosis, kinking, or extrinsic compression. Renal allograft compartment syndrome (RACS) is an unrecognized cause of early allograft dysfunction. This complication is characterized by increased pressure of the iliac fossa that reduces the blood supply to the graft with a potentially devastating consequence. Read More

    Application of microwave ablation in the emergent control of intraoperative life threatening tumor hemorrhage during hepatic surgeries.
    Int J Hyperthermia 2017 Oct 5:1-11. Epub 2017 Oct 5.
    a Department of Liver Surgery , the First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Living Donor Liver Transplantation, National Health and Family Planning Commission , Nanjing , China.
    Purpose: This study was designed to evaluate the efficacy and safety of microwave ablation (MWA) in the treatment of intraoperative life-threatening tumor hemorrhage during hepatic surgeries.

    Methods: Three cases of MWA application in the emergent control of life-threatening hepatic tumor hemorrhage were analyzed and reported.

    Results: Satisfactory hemostasis for hepatic tumor rupture was achieved by MWA in all three cases. Read More

    Multifaceted effects of astragaloside IV on promotion of random pattern skin flap survival in rats.
    Am J Transl Res 2017 15;9(9):4161-4172. Epub 2017 Sep 15.
    Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical UniversityWenzhou 325027, China.
    Random pattern skin flap transplantation is frequently applied in plastic and reconstructive surgery, but the distal part of skin flaps often suffers necrosis due to ischemia. Astragaloside IV (AS-IV), a natural saponin purified from Astragalus membranaceus, may have beneficial functions for flap survival. In this study, rats were divided into a control group and an AS-IV treatment group, and underwent surgery using a modified "McFarlane flap" model. Read More

    Transplantation Treatment of Extensive Soft-Tissue Defects in Lower Extremities with a Combination of Cross-Bridge Flap and Combined Free-Tissue Flap Covered by Vacuum Sealing Drainage: One Case Report.
    Open Orthop J 2017 31;11:704-713. Epub 2017 Jul 31.
    Department of Orthopaedic and Traumatology, North District hospital, Sheung Shui, Hong Kong.
    This article reported the ultilization of cross-bridge flap transplantation and combined free-tissue flap transplantation to treat a 54-year-old male with Gustilo type III-C injuries. Thorough debridement, external fixation and vacuum sealing drainage were performed in the fist-stage treatment. After the removal of negative pressure on VSD devices, the joined free-tissue flaps and the cross-bridge flap were performed to repair the extensive soft-tissue defects. Read More

    Selective blockade of CD28 on human T cells facilitates regulation of alloimmune responses.
    JCI Insight 2017 Oct 5;2(19). Epub 2017 Oct 5.
    Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom.
    T cells are central to the detrimental alloresponses that develop in autoimmunity and transplantation, with CD28 costimulatory signals being key to T cell activation and proliferation. CTLA4-Ig molecules that bind CD80/86 and inhibit CD28 costimulation offer an alternative immunosuppressive treatment, free from some of the chronic toxicities associated with calcineurin inhibition. However, CD80/86 blockade by CTLA4-Ig also results in the loss of coinhibitory CTLA4 signals that are critical to the regulation of T cell activation. Read More

    Nanofat-derived stem cells with platelet-rich fibrin improve facial contour remodeling and skin rejuvenation after autologous structural fat transplantation.
    Oncotarget 2017 Sep 31;8(40):68542-68556. Epub 2017 Jul 31.
    Department of Plastic and Aesthetic Surgery, The Fifth Affiliated Hospital of Guangxi Medical University & The First People's Hospital of Nanning, Nanning 530022, China.
    Traditional autologous fat transplantation is a common surgical procedure for treating facial soft tissue depression and skin aging. However, the transplanted fat is easily absorbed, reducing the long-term efficacy of the procedure. Here, we examined the efficacy of nanofat-assisted autologous fat structural transplantation. Read More

    Identification and causes of metabonomic difference between orthotopic and subcutaneous xenograft of pancreatic cancer.
    Oncotarget 2017 Sep 22;8(37):61264-61281. Epub 2017 May 22.
    Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou 350001, China.
    Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal tumors. However, the methodological differences between orthotopic and subcutaneous xenograft (OX and SX) models will cause confusion in understanding its pathological mechanism and clinical relevance. In this study, SX and OX models were established by implanting Panc-1 and BxPC-3 cell strains under skin and on the pancreas of mice, respectively. Read More

    Association of Autologous Costal Cartilage Harvesting Technique With Donor-Site Pain in Patients Undergoing Rhinoplasty.
    JAMA Facial Plast Surg 2017 Sep 21. Epub 2017 Sep 21.
    Department of Biostatistics, Bezmiâlem Vakif University, Istanbul, Turkey.
    Importance: Postoperative pain at the donor site is a common morbidity following autologous costal cartilage grafting.

    Objective: To evaluate postoperative pain at the donor site after the use of a muscle-sparing costal cartilage harvesting technique compared with a muscle-cutting technique using electrocautery.

    Design, Setting, And Participants: Designed as a controlled trial without randomization, this prospective, comparative cohort study was conducted between January 1, 2016, and March 31, 2017. Read More

    Periorbital Necrotizing Fasciitis Induced by Streptococcus pyogenes: A Case Report and Clarification.
    J Oral Maxillofac Surg 2017 Sep 11. Epub 2017 Sep 11.
    Head of Department and Professor, Division of Stomatology, Maxillo-Facial and Plastic Surgery, Centre Hospitalier Lyon Sud, Pierre Bénite, France.
    Periorbital necrotizing fasciitis (PONF) is a rare condition of the face. PONF can lead to blindness, functional and esthetic sequelae, multiple-organ failure, and death. The aim of this report is to raise the awareness of this severe condition in maxillofacial surgeons. Read More

    Fibrinogen-modified sodium alginate as a scaffold material for skin tissue engineering.
    Biomed Mater 2017 Oct 3. Epub 2017 Oct 3.
    National Reseach Centre Kurchatov Institute, Moscow, RUSSIAN FEDERATION.
    In search for a new pro-angiogenic scaffold material suitable for skin bioengineering and grafting therapy, we have fabricated a number of composite sodium alginate (AG) - fibrinogen (FG) sponge scaffolds using the freeze-drying approach. Thrombin was added to drive FG/fibrin conversion, while ε-aminocapronic acid (εAc) was used as antifibrinolytic component. The slow rates of scaffold biodegradation were achieved by using Ca2+ and Mg2+ cations as cross-linking agents. Read More

    Chemoprevention of Skin Carcinomas in High-Risk Transplant Recipients.
    Curr Med Chem 2017 Oct 3. Epub 2017 Oct 3.
    San Raffaele Scientific Institute, Vita Salute San Raffaele University, v. Olgettina 58, 20132 Milano. Italy.
    Long-term immunosuppressive therapy, as provided to solid organ transplant recipients, inevitably results in a significant inhibition of immune defenses; this leads to frequent skin infections and malignancies, which represent an important cause of morbidity and mortality for transplanted patients. The incidence and risk of skin carcinomas are elevated in solid organ transplant recipients in comparison with the general population, with a 10-fold increased risk for basal cell carcinoma and a 50-100-fold for squamous cell carcinoma. The schedule of immunosuppressive drugs influences the type and timing of skin malignancies, but a crucial role is also played by endogenous and exogenous risk factors. Read More

    Primary Merkel Cell Carcinoma on the Cheek: Three Case Reports.
    J Coll Physicians Surg Pak 2017 Sep;27(9):S122-S124
    Department of Urinary Surgery, Affiliated Hospital of Inner Mongolia University for the Nationalities, Tongliao, 028007, The Inner Mongolia Autonomous Region, China.
    Merkel cell carcinoma (MCC) is a rare aggressive cutaneous neuroendocrine carcinoma that typically arises in sunexposed areas of the skin. Herein, we present three cases of primary MCC of the cheek. Case 1 had multiple nodules and mild swelling on the left cheek and eyelids, the patient did not receive any treatment and died after 10 months. Read More

    Pulmonary Pathologic Manifestations of Anti-Alanyl-tRNA Synthetase (Anti-PL-12)-Related Inflammatory Myopathy.
    Arch Pathol Lab Med 2017 Oct 2. Epub 2017 Oct 2.
    Context: - Patients with anti-aminoacyl-tRNA synthetase syndrome (ARS), a subset of idiopathic inflammatory myopathy, have a high prevalence of lung involvement. Autoantibodies directed against alanyl-tRNA synthetase (anti-PL-12 Abs) represent 1 of the 8 autoantibodies currently described under the rubric of ARS.

    Objective: - To describe the clinical, radiographic, and pulmonary histopathologic findings in patients possessing anti-PL-12 autoantibodies. Read More

    A toxicity cost function approach to optimal CPA equilibration in tissues.
    Cryobiology 2017 Sep 28. Epub 2017 Sep 28.
    Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Georgia.
    There is growing need for cryopreserved tissue samples that can be used in transplantation and regenerative medicine. While a number of specific tissue types have been successfully cryopreserved, this success is not general, and there is not a uniform approach to cryopreservation of arbitrary tissues. Additionally, while there are a number of long-established approaches towards optimizing cryoprotocols in single cell suspensions, and even plated cell monolayers, computational approaches in tissue cryopreservation have classically been limited to explanatory models. Read More

    Safety of avoiding systemic corticosteroid administration for grade II acute graft-versus-host disease limited to the skin.
    Ann Hematol 2017 Sep 30. Epub 2017 Sep 30.
    Division of Hematology, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya-ku, Saitama-City, Saitama, 330-8503, Japan.
    We hypothesized that systemic corticosteroid administration would be safely avoided not only in grade I acute graft-versus-host disease (GVHD) but also in selected patients with grade II acute GVHD limited to the skin (grade IIs GVHD). We retrospectively evaluated risk factors for subsequent GVHD progression, defined as the involvement of other organs or progression to grade III to IV GVHD, in 50 patients with acute GVHD of grade IIs at its onset. Sixteen patients received systemic corticosteroid administration before GVHD progression. Read More

    Management of Head and Neck Burns-A 15-Year Review.
    J Oral Maxillofac Surg 2017 Sep 11. Epub 2017 Sep 11.
    Assistant Professor, Division of Oral and Maxillofacial Surgery, Department of Surgery, Emory University School of Medicine; Associate Chief, Section of Dentistry/Oral and Maxillofacial Surgery, Children's Healthcare of Atlanta, Atlanta, GA. Electronic address:
    Purpose: The purpose of this project was to characterize patients with isolated head and neck burns admitted to the Grady Memorial Hospital (GMH) Burn Center (Atlanta, GA).

    Materials And Methods: This was a retrospective case series of patients admitted to the GMH Burn Center with the primary diagnosis of head and neck burns from 2000 through 2015. Demographic data (gender and age) were recorded. Read More

    An Innovative Way to Separate Gastrointestinal and Abdominal Wall Reconstruction after Complex Abdominal Trauma.
    Am Surg 2017 Sep;83(9):1001-1006
    Despite advances in trauma care, a subset of patients surviving damage control cannot achieve fascial closure and require split-thickness skin grafting (STSG) of their open abdomen. Controversy exists as to whether reconstruction of the gastrointestine (GI) should be staged or performed at the time of abdominal wall reconstruction (AWR). Many surgeons do not believe that operations through the STSG can be completed safely or without loss of graft. Read More

    [Clinical effect of vacuum sealing drainage in the treatment of complex fracture and dislocation of foot with severe soft tissue injury].
    Zhonghua Yi Xue Za Zhi 2017 Sep;97(35):2746-2750
    Department of Foot and Ankle, the Second Hospital of Tangshan, Hebei 063000, China.
    Objective: To observe the clinical effect of vacuum sealing drainage (VSD) in the treatment of complex fracture and dislocation of foot with severe soft tissue injury. Methods: From March 2012 to January 2015, a retrospective analysis of 108 cases of the foot closed complex fracture dislocation with severe soft tissue injury in Department of Foot and Ankle, the Second Hospital of Tangshan City, Tangshan.Injury mechanisms included press and crush injury, traffic accident. Read More

    Study of factors affecting the incidence of skin cancer in patients after liver transplant.
    An Bras Dermatol 2017 Jul-Aug;92(4):492-498
    Department of Pathologic Anatomy of School of Medical Sciences of Universidade Estadual de Campinas (FCM-Unicamp) - Campinas (SP), Brazil.
    Background:: Many factors are currently being identified as potential inductors of skin cancer in patients after a liver transplant, among them, immunosuppressive regimen.

    Objective:: To study the factors that influence the incidence of skin cancer in patients after liver transplant.

    Methods:: We have carried out a retrospective and observational study with 170 transplanted patients who had undergone transplantation from 1997 to 2010. Read More

    Lymphatic Reconstitution and Regeneration After Face Transplantation.
    Ann Plast Surg 2017 Nov;79(5):505-508
    From the *Hansjörg Wyss Department of Plastic Surgery, NYU Langone Medical Center, New York, NY; †Division of Plastic and Reconstructive Surgery, Louisiana State University Health Sciences Center School of Medicine, New Orleans, LA; and ‡Department of Pathology, University of Maryland Medical Center, Baltimore, MD.
    Background: The purpose of this study was to investigate whether lymphatic reconstitution and regeneration occurs after clinical facial transplantation using indocyanine green lymphography and immunohistochemical markers.

    Methods: Allograft skin biopsies at multiple posttransplant time points were stained with Lyve1 lymphatic antibody and other endothelial antibodies. Staining intensity was interpreted on a scale of none, mild, moderate, and strong by 2 investigators and consolidated by a third party for final interpretation. Read More

    In Situ Silver Nanowire Deposited Cross-Linked Carboxymethyl Cellulose: A Potential Transdermal Anticancer Drug Carrier.
    ACS Appl Mater Interfaces 2017 Oct 12. Epub 2017 Oct 12.
    Polymer Chemistry Laboratory, Department of Applied Chemistry, Indian Institute of Technology (ISM) , Dhanbad 826004, India.
    Recently, a novel biopolymeric nanocomposite hydrogel comprised of in situ formed silver nanowires (AgNWs) deposited chemically cross-linked carboxymethyl cellulose (CMC) has been developed, which demonstrates superior efficacy as anticancer drug-curcumin carrier. The cross-linked polymer has been prepared by grafting poly [2-(methacryloyloxy) ethyl trimethylammonium chloride] on CMC using diethylene glycol dimethacrylate cross-linker. The nanocomposite hydrogel has the capability to encapsulate both hydrophobic/hydrophilic transdermal drugs. Read More

    Effects of Human Adipose-Derived Stem Cells on the Survival of Rabbit Ear Composite Grafts.
    Arch Plast Surg 2017 Sep 15;44(5):370-377. Epub 2017 Sep 15.
    Institute for Human Tissue Restoration, Department of Plastic and Reconstructive Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
    Background: Composite grafts are frequently used for facial reconstruction. However, the unpredictability of the results and difficulties with large defects are disadvantages. Adipose-derived stem cells (ADSCs) express several cytokines, and increase the survival of random flaps and fat grafts owing to their angiogenic potential. Read More

    Management of syndromic diarrhea/tricho-hepato-enteric syndrome: A review of the literature.
    Intractable Rare Dis Res 2017 Aug;6(3):152-157
    Aix Marseille Université, INSERM, Génétique Médicale et Génomique Fonctionnelle (GMGF), UMRS 910, Marseille, France.
    Syndromic diarrhea/tricho-hepato-enteric syndrome (SD/THE) is a rare disease linked to the loss of function of either TTC37 or SKIV2L, two components of the SKI complex. It is characterized by a combination of 9 signs (intractable diarrhea, hair abnormalities, facial dysmorphism, immune abnormalities, IUGR/SGA, liver abnormalities, skin abnormalities, congenital heart defect and platelet abnormalities). We present a comprehensive review of the management of SD/THE and tested therapeutic regimens. Read More

    Surgical treatment of a lumbar aneurysmal bone cyst using percutaneous endoscopic lumbar discectomy.
    Eur Spine J 2017 Sep 23. Epub 2017 Sep 23.
    Department of Orthopaedic Surgery, Teikyo University Mizonokuchi Hospital, 3-8-3 Mizonokuchi, Takatsu-ku, Kawasaki, Kanagawa, 213-8507, Japan.
    Purpose: Aneurysmal bone cysts of the lumbar spine are usually treated by curettage followed by bone or bioactive ceramics grafting. Here, we present the first case of an aneurysmal bone cyst of the lumbar spine treated by percutaneous endoscopic lumbar discectomy (PELD).

    Methods: We describe the clinical characteristics of the patient including the radiological and pathological findings of the tumor and the surgical technique used. Read More

    Burn injury: Challenges and advances in burn wound healing, infection, pain and scarring.
    Adv Drug Deliv Rev 2017 Sep 20. Epub 2017 Sep 20.
    Burns Research Group, ANZAC Research Institute, Concord Hospital, University of Sydney, Concord West, NSW 2139, Australia; Burns and Reconstructive Surgery Unit, Concord Hospital, Concord West, NSW 2139, Australia. Electronic address:
    Severe burn injuries are the most traumatic and physically debilitating injuries affecting nearly every organ system and leading to significant morbidity and mortality. Early burn wound excision and skin grafting are common clinical practices that have significantly improved the outcomes for severe burn injured patients by reducing mortality rate and days of hospital stay. However, slow wound healing, infection, pain, and hypertrophic scarring continue to remain a major challenge in burn research and management. Read More

    Use of a fibrinogen-thrombin sponge in rhinoplasty.
    HNO 2017 Sep 22. Epub 2017 Sep 22.
    Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Grosshadern Campus Ludwig-Maximilian-University Munich, Marchioninistr. 15, 81377, Munich, Germany.
    Background: Although several methods have been described to address nasal dorsum augmentation and smoothing of irregularities in rhinoplasty, establishing the ideal method has proven controversial.

    Objective: Here, we introduce a novel technique of cartilage grafting for nasal dorsum augmentation by wrapping cartilage in a fibrinogen- and thrombin-coated collagen patch called TachoSil®.

    Material And Methods: In a pilot study comprising ten cases, the use of the collagen patch was examined in various indications in rhinoplasty. Read More

    HLA-Haploidentical Stem Cell Transplant with Pre-Transplant Immunosuppression for Patients with Sickle Cell Disease.
    Biol Blood Marrow Transplant 2017 Sep 19. Epub 2017 Sep 19.
    Department of Pediatrics, City of Hope, Duarte, CA.
    Allogeneic stem cell transplantation (HCT) is curative in patients with severe sickle cell disease (SCD) but a significant number of patients lack a HLA-identical sibling or matched unrelated donor. Mismatched related (haploidentical) HCT with post-transplant cyclophosphamide (PTCY) allows expansion of the donor pool but is complicated by high rates of graft failure. In this report, we describe a favorable haploidentical HCT approach in a limited cohort of sickle cell patients with significant co-morbidities. Read More

    Muscle versus Fasciocutaneous Free Flaps in Lower Extremity Traumatic Reconstruction: A Multicenter Outcomes Analysis.
    Plast Reconstr Surg 2017 Sep 15. Epub 2017 Sep 15.
    1Division of Plastic and Reconstructive Surgery, Duke University Medical Center, Durham, NC, 27710, USA 2Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA 3Division of Plastic Surgery, University of Pennsylvania Health System, Philadelphia, PA, 19104, USA 4Department of Orthopaedic Surgery, University of Pennsylvania Health System, Philadelphia, PA, 19104, USA.
    Purpose: Clinical indications are expanding for the use of fasciocutaneous free flaps in lower extremity traumatic reconstruction. We assessed the impact of muscle versus fasciocutaneous free flap coverage on reconstructive and functional outcomes.

    Methods: A multicenter retrospective review was conducted on all lower extremity traumatic free flaps performed at Duke University (1997-2013) and the University of Pennsylvania (2002-2013). Read More

    Tolerance in xenotransplantation.
    Curr Opin Organ Transplant 2017 Sep 20. Epub 2017 Sep 20.
    aColumbia Center for Translational Immunology, Department of Medicine bDepartment of Surgery cDepartment of Microbiology & Immunology, Columbia University, New York, New York, USA.
    Purpose Of Review: This review describes recent progress in tolerance-inducing strategies across xenogeneic immunological barriers as well as the potential benefit of a tolerance strategy for islets and kidney xenotransplantation.

    Recent Findings: Using advanced gene editing technologies, xenotransplantation from multitransgenic alpha-1,3-galactosyltransferase knockout pigs has demonstrated marked prolongation of renal xenograft survival, ranging from days to greater than several months for life-supporting kidneys, and more than 2 years in a heterotopic nonlife-supporting cardiac xenograft model. Continuous administration of multiple immunosuppressive drugs has been required and attempts to taper immunosuppression have been unsuccessful. Read More

    FOXN1 Deficiency: from the Discovery to Novel Therapeutic Approaches.
    J Clin Immunol 2017 Sep 21. Epub 2017 Sep 21.
    Department of Translational Medical Sciences, Section of Pediatrics, Federico II University, Via S. Pansini, 5, 80131, Naples, Italy.
    Since the discovery of FOXN1 deficiency, the human counterpart of the nude mouse, a growing body of evidence investigating the role of FOXN1 in thymus and skin, has been published. FOXN1 has emerged as fundamental for thymus development, function, and homeostasis, representing the master regulator of thymic epithelial and T cell development. In the skin, it also plays a pivotal role in keratinocytes and hair follicle cell differentiation, although the underlying molecular mechanisms still remain to be fully elucidated. Read More

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