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    1 OF 1121

    A potential role of the unfolded protein response in post-transplant cancer.
    Clin Sci (Lond) 2017 Jul 22;131(13):1429-1436. Epub 2017 Jun 22.
    Service de Biochimie, Centre de Biologie Humaine (CBH), CHU Amiens Sud, Amiens, France
    Cancer is one of the major causes of mortality in organ transplant patients receiving immunosuppressive regimen based on Cyclosporin A (CsA). Organ transplantation and chronic immunosuppression are typically associated with skin cancers (both squamous cell carcinoma and melanoma) and renal cell carcinoma (RCC). Recent studies have shown that in addition to its immunosuppressive effects, accounted for by the inhibition of calcineurin and the modulation of the transcriptional programme of lymphocytes, CsA also directly stimulates the growth and aggressive behaviour of various cancer cells. Read More

    Shake It Off: A Randomized Pilot Study of the Effect of Whole Body Vibration on Pain in Healing Burn Wounds.
    J Burn Care Res 2017 Jul/Aug;38(4):e756-e764
    From the *DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Florida; †Department of Occupational Therapy, Jackson Memorial Hospital. Miami, Florida; and ‡Department of Physical Therapy, Jackson Memorial Hospital. Miami, Florida.
    Whole body vibration (WBV) has been shown to improve strength in extremities with healed burn wounds. We hypothesize that WBV reduces pain during rehabilitation compared to standard therapy alone. Patients with ≥1% TBSA burn to one or more extremities from October 2014 to December 2015 were randomized to vibration (VIBE) or control. Read More

    Burn Patient Acuity Demographics, Scar Contractures, and Rehabilitation Treatment Time Related to Patient Outcomes: The ACT Study.
    J Burn Care Res 2017 Jul/Aug;38(4):230-242
    From the *U.S. Army Institute of Surgical Research Burn Center, JBSA Fort Sam Houston, Texas; †Oak Ridge Institute for Science and Education, San Antonio, Texas; and ‡Pennsylvania State University, State College.
    In 2008, the U.S. Department of Defense funded a rehabilitation study through the American Burn Association titled "Burn patient acuity demographics, scar contractures, and rehabilitation treatment time related to patient outcomes," commonly known at the ACT study. Read More

    Correction of Rhytides, Peau d'Orange, and Thin Dermis of the Face by Neocollagenesis Using Novel Collagen Stimulating Slurry Protocol.
    Aesthetic Plast Surg 2017 Jun 22. Epub 2017 Jun 22.
    Division of Plastic Surgery, University of California San Diego, School of Medicine, San Diego, CA, USA.
    We reviewed 200 patient records from 2009 to 2015 of individuals who presented at the authors offices for facial wrinkle reduction and who on physical examination had rhytides, peau d'orange, or thin dermis and underwent novel adipose slurry injections. The patients were evaluated at week 2, 1, 3 and 6 months revealing an 80, 60 and 40% improvement in rhytides and dermis density, respectively. We present the protocol and description of a reasonable alternative or adjunct to manufactured fillers that is comprised of autologous adipose, stem cells, and growth factor slurry. Read More

    Complications of Fat Transfer for Breast Augmentation.
    Aesthetic Plast Surg 2017 Jun 22. Epub 2017 Jun 22.
    DrK Medical Group, Athens, Greece.
    Autologous fat grafting is quite common for breast augmentations as well as for reconstructive breast surgery. Coleman has described the surgical technique of fat grafting. Fat is harvested, and after centrifugation and refinement, blunt infiltration cannulas are used to place the fat through small incisions. Read More

    [Clinical and Pathologic Features of Myeloid Sarcoma].
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 2017 Jun;25(3):926-931
    Department of Hematology, The Second People's Hospital of Lianyungang City, Lianyungang 222000, Jiangsu Province, China.
    Objective: To explore the clinicopathologic features, differential diagnosis and therapy of myeloid sarcoma.

    Methods: The clinical data including clinical manifestations, laboratorial tests, histopathologicical examination, immunohistochemistry and clinical prognosis of 10 patients with myeloid sarcoma were analyzed retrospectively. Among 10 patients, 5 male and 5 female, aged 23 to 71 years old (median = 36 years). Read More

    Pediatric cutaneous graft versus host disease: A review.
    Curr Pediatr Rev 2017 Jun 14. Epub 2017 Jun 14.
    Brigham and Women's Hospital, Boston, Massachusetts. United States.
    Background: Graft versus host disease (GVHD) is a significant complication following hematopoietic stem cell transplantation in the pediatric population. The most common clinical manifestation of GVHD is in the skin. This article will present a review of key concepts related to pediatric cutaneous GVHD, including pathophysiology, clinical epidemiology, diagnosis, and treatment options. Read More

    Restoration of Cutaneous Pigmentation by Transplantation to Mice of Isogeneic Human Melanocytes in Dermal-epidermal Engineered Skin Substitutes.
    Pigment Cell Melanoma Res 2017 Jun 22. Epub 2017 Jun 22.
    Departments of Surgery, University of Cincinnati.
    Autologous engineered skin substitutes (ESS) containing melanocytes (hM) may restore pigmentation, and photoprotection after grafting to full-thickness skin wounds. In the current study, normal hM were isolated from discard skin, propagated with or without tyrosinase inhibitors, cryopreserved, recovered into culture, and added to ESS (ESS-P) before transplantation. ESS-P were incubated in either UCMC160/161 or UCDM1 medium, scored for hM densities, and grafted to mice. Read More

    Topical Delivery of Immunosuppression to Prolong Xenogeneic and Allogeneic Split-Thickness Skin Graft Survival.
    J Burn Care Res 2017 Jun 7. Epub 2017 Jun 7.
    From the *Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA; †Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA; ‡ Department of Life Sciences, The New Jersey Center for Biomaterials, Rutgers-the State University of New Jersey, Piscataway, NJ; §Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; and ‖Department of Biology, Emmanuel College, Boston, MA.
    Cadaveric skin allograft is the current standard of treatment for temporary coverage of large burn wounds. Porcine xenografts are viable alternatives but undergo α-1,3-galactose (Gal)-mediated hyperacute rejection and are lost by POD 3 because of naturally occurring antibodies to Gal in primate recipients. Using baboons, we previously demonstrated that xenografts from GalT-KO swine (lacking Gal) provided wound coverage comparable with allografts with systemic immunosuppression. Read More

    Selective CD28 blockade results in superior inhibition of donor-specific T follicular helper cell and antibody responses relative to CTLA-4-Ig.
    Am J Transplant 2017 Jun 21. Epub 2017 Jun 21.
    Emory Transplant Center, Atlanta, GA, USA.
    Donor-specific antibodies (DSA) are a barrier to improved long-term outcomes following kidney transplantation. Costimulation blockade with CTLA-4-Ig has shown promise as a potential therapeutic strategy to control DSA. T follicular helper (Tfh) cells, a subset of CD4(+) T cells required for optimum antibody production, are reliant on the CD28 costimulatory pathway. Read More

    Absence of γ-chain in keratinocytes alters chemokine secretion resulting in reduced immune cell recruitment.
    J Invest Dermatol 2017 Jun 17. Epub 2017 Jun 17.
    Institute of Immunity and Transplantation, University College London, London, United Kingdom; Department of Immunology, Royal Free Hospital Foundation Trust, London, United Kingdom. Electronic address:
    Loss of function mutations in the common gamma (γc) chain cytokine receptor subunit give rise to severe combined immunodeficiency (SCID) characterised by lack of T and natural killer cells and infant death from infection. Haematopoietic stem cell transplantation or gene therapy offer cure but despite successful replacement of lymphoid immune lineages a long-term risk of severe cutaneous human papilloma virus (HPV) infections persists, possibly related to persistent γc-deficiency in other cell types. Here we demonstrate that keratinocytes, the only cell type directly infected by HPV, express functional γc and its co-receptors. Read More

    Acute pneumatosis cystoides intestinalis with atrophic desmosis of the colon in a child.
    BMJ Case Rep 2017 Jun 19;2017. Epub 2017 Jun 19.
    Department of Pediatric Surgery, University Children's Hospital Basel, Basel, Switzerland.
    Acute pneumatosis cystoides intestinalis (PCI) has been described after bone marrow transplantation (BMT). Several case series have demonstrated successful conservative treatment of PCI in children. We present a child with Fanconi anaemia, who developed severe graft versus host disease of the gastrointestinal tract, skin and liver after BMT and an acute, severe form of PCI. Read More

    The modified Ulaanbaatar procedure: Reduced complications and enhanced cosmetic outcome for the most severe cases of hypospadias.
    J Pediatr Urol 2017 May 18. Epub 2017 May 18.
    Division of Urology, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA.
    Introduction/objective: Proximal hypospadias is one of the most challenging conditions that pediatric urologists have to deal with. Many procedures have been devised over the years, but nothing has been proven to be the best option. Although there have been some attempts at correcting severe hypospadias in one procedure, most have advocated a staged approach. Read More

    Systemic antimicrobial prophylaxis in burn patients: a systematic review.
    J Hosp Infect 2017 Jun 16. Epub 2017 Jun 16.
    Hospital Cosme Argerich, Department of Intensive Care Medicine, Sanatorio Dupuytren, Cesar Diaz 3026, 1416 Buenos Aires, Argentina.
    Objective: To review studies of systemic antibiotic prophylaxis in burn patients.

    Methods: Human clinical trials during the period 1966-2016 where prophylactic systemic antibiotics were compared with placebo or no intervention were identified in electronic databases.

    Results: Nineteen trials met the selection criteria. Read More

    Severe disease and greater impairment of NF-κB activation in IκBa point mutants versus truncation mutants in autosomal dominant anhidrotic ectodermal dysplasia with immune deficiency.
    J Allergy Clin Immunol 2017 Jun 16. Epub 2017 Jun 16.
    Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA. Electronic address:
    Background: Autosomal dominant anhidrotic ectodermal dysplasia with immune deficiency (AD EDA-ID) is caused by heterozygous point mutations at or close to S32 and S36 or N-terminal truncations in IκBα that impair its phosphorylation and degradation, and thus activation of the canonical NF-κB pathway. The outcome of hematopoietic stem cell transplantation is poor in AD EDA-ID despite achievement of chimerism. Mice heterozygous for the S32I mutation in IκBα have impaired non-canonical NF-κB activity and defective lymphorganogenesis. Read More

    A pilot study comparing histological and immunophenotypic patterns in stage 4 skin graft versus host disease from toxic epidermal necrolysis.
    J Cutan Pathol 2017 Jun 19. Epub 2017 Jun 19.
    Harvard Medical School, Boston, Massachusetts.
    Since the inception of bone marrow transplantation, clinicians have sought to distinguish stage 4 skin graft versus host disease (GVHD) from toxic epidermal necrolysis (TEN).(1-3) In certain contexts, it can be difficult to discern among these two entities, both clinically and histologically. However, the distinction is critical because both diseases can be life-threatening and their respective management and prognosis differ. Read More

    Invasive Aspergillosis with Disseminated Skin Involvement in a Patient with Acute Myeloid Leukemia: A Rare Case.
    Hematol Rep 2017 Jun 1;9(2):6997. Epub 2017 Jun 1.
    Hematology Clinic and Bone Marrow Transplantation Unit, Ankara, Turkey.
    Invasive pulmonary aspergillosis is most commonly seen in immunocompromised patients. Besides, skin lesions may also develop due to invasive aspergillosis in those patients. A 49-year-old male patient was diagnosed with acute myeloid leukemia. Read More

    A case grafted with polyglycolic acid sheets and fibrin glue for protection after temporary resection of a metastatic cervical skin tumor.
    Auris Nasus Larynx 2017 Jun 14. Epub 2017 Jun 14.
    Department of Otolaryngology, Fukushima Medical University, Japan.
    The aim of this case report was to evaluate the usefulness of a grafting with polyglycolic acid sheet and a fibrin glue spray (PGA sheet grafting) after resection of a cervical skin tumor. A 61-year-old woman presented with left cervical skin tumor resistance to chemo-radiotherapy. She had been undergoing multimodal therapy for ovarian serous papillary adenocarcinoma for the previous six years. Read More

    Gamma-delta T-cell lymphoma of skin, eye and brain presenting with visual loss.
    BMJ Case Rep 2017 Jun 15;2017. Epub 2017 Jun 15.
    Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, Merseyside, UK.
    A young man presented with rapid, predominantly right-sided visual loss with a background of multifocal skin lesions. Visual acuity was right hand movements, left 6/5 Snellen, deteriorating to 6/38. He showed panuveitis with bilateral multifocal retinal infiltrates and retinal vasculitis. Read More

    Current and emerging treatments for vitiligo.
    J Am Acad Dermatol 2017 Jul;77(1):17-29
    Department of Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts.
    Clinicians should be aware that vitiligo is not merely a cosmetic disease and that there are safe and effective treatments available for vitiligo. It is important to recognize common and uncommon presentations and those with active disease, as well as their implications for clinical management; these were discussed in the first article in this continuing medical education series. Existing treatments include topical and systemic immunosuppressants, phototherapy, and surgical techniques, which together may serve to halt disease progression, stabilize depigmented lesions, and encourage repigmentation. Read More

    Minimising the donor area morbidity of radial forearm phalloplasty using prefabricated thigh flap: A new technique.
    Indian J Plast Surg 2017 Jan-Apr;50(1):91-95
    Department of Plastic, Reconstructive and Aesthetic Surgery, Medanta - The Medicity, Sector 38, Gurgaon, Haryana, India.
    Phalloplasty is indicated in various conditions of penile loss or absence. There are numerous techniques for phalloplasty including the pedicle and free flaps with the ultimate goal of micturition in standing position, attaining adequate size, aesthesis and sensations for sexual intercourse. Radial forearm phalloplasty is the gold standard flap to achieve above results but gives a very bad scar on the forearm. Read More

    Role of customised negative-pressure wound therapy in the integration of split-thickness skin grafts: A randomised control study.
    Indian J Plast Surg 2017 Jan-Apr;50(1):43-49
    Department of Plastic and Reconstructive Surgery, SKIMS, Srinagar, Jammu and Kashmir, India.
    Background: Split-thickness skin grafting (STSG) is a time-tested technique in wound cover, but many factors lead to suboptimal graft take. Role of custom-made negative-pressure wound therapy (NPWT) is compared with conventional dress in the integration of STSG and its cost is compared with widely used commercially available NPWT.

    Materials And Methods: This is a parallel group randomised control study. Read More

    End-stage kidney disease in patient with epidermolysis bullosa - what are the treatment options? - case report.
    BMC Nephrol 2017 Jun 14;18(1):193. Epub 2017 Jun 14.
    Department of Nephrology, Transplantation and Internal Medicine, Pomeranian Medical University, Al. Powstańców Wielkopolskich 72, 70-111, Szczecin, Poland.
    Background: Epidermolysis bullosa is a group of diseases caused by mutations in genes for proteins responsible for cells' anchorage at the dermo-epidermal junction. Their common feature are dysfunctional or even absent connections between cells. The typical clinical sign is the formation of blisters, with possible excessive scarring, in response to minimal skin irritation. Read More

    Differential effects of Losartan and Atorvastatin in partial and full thickness burn wounds.
    PLoS One 2017 14;12(6):e0179350. Epub 2017 Jun 14.
    Association of Dutch Burn Centres, Beverwijk, The Netherlands.
    Healing of burn wounds is often associated with scar formation due to excessive inflammation and delayed wound closure. To date, no effective treatment is available to prevent the fibrotic process. The Renin Angiotensin System (RAS) was shown to be involved in fibrosis in various organs. Read More

    Prevention of livedoid vasculopathy recurrence by prolonged administration of rivaroxaban.
    J Eur Acad Dermatol Venereol 2017 Jun 13. Epub 2017 Jun 13.
    Universitaetsklinikum Münster, Klinik für Hautkrankheiten, Von-Esmarch-Strasse 58, 48149, Muenster.
    A 49-year-old man with known livedoid vasculopathy presented with recurrent painful (VAS 8/10) ulceration and necrosis on the foot (Figure 1). He was formerly treated with prostacyclin infusions, acetylsalicylic acid, intravenous immunoglobulins, different systemic antibiotics and a skin grafting. At admission an antithrombotic therapy with enoxaparin (Clexane(®) ) in a dose of 1 mg/ kg bodyweight (100 mg) once daily was initiated. Read More

    Digit preserving surgery of subungual melanoma, a case series using vacuum assisted closure and full thickness skin grafting.
    J Eur Acad Dermatol Venereol 2017 Jun 13. Epub 2017 Jun 13.
    Department of Dermatology and Dermatosurgery, Helios Hospital Rottweil, Germany.
    Acrolentiginous melanoma (ALM) is the second most common nail organ tumour and frequently, affects the thumb or the great toe.(1,2) Digit amputation is still the gold standard for many surgeons;(3) it does, however, not protect against local recurrence. An alternative represents complete tumour resection with distal phalanx preservation, which has proven valuable, especially for well demarcated thinner tumours. Read More

    Unstable Open Posterior Subtalar Dislocation Treated With a Ring External Fixator: A Case Report and Review of the Literature.
    J Foot Ankle Surg 2017 Jun 9. Epub 2017 Jun 9.
    Consultant, University Orthopaedics, Hand and Reconstructive Microsurgery Cluster, National University Health System, Singapore.
    Traumatic dislocation of the subtalar joint is an infrequently occurring injury, with open true posterior dislocation an even rarer injury. We describe our treatment of a young motorcyclist who was brought into hospital after a road traffic accident, having sustained an open posterior subtalar dislocation. After initial reduction and resuscitation in the emergency department, he was taken to the operating theater for emergent wound debridement and external fixation of his ankle using a unilateral external fixator device. Read More

    Cellular Therapies for Treatment of Radiation Injury: Report from a NIH/NIAID and IRSN Workshop.
    Radiat Res 2017 Jun 12. Epub 2017 Jun 12.
    b   Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Fontenay-aux-Roses, France.
    In recent years, there has been increasing concern over the possibility of a radiological or nuclear incident occurring somewhere in the world. Intelligence agencies frequently report that terrorist groups and rogue nations are seeking to obtain radiological or nuclear weapons of mass destruction. In addition, there exists the real possibility that safety of nuclear power reactors could be compromised by natural (such as the tsunami and subsequent Fukushima accident in Japan in March, 2011) or accidental (Three Mile Island, 1979 and Chernobyl, 1986) events. Read More

    The Periosteal Medial Femoral Condyle Free Flap: A New Option for Soft Tissue Reconstruction of the Distal Lower Extremity.
    Ann Plast Surg 2017 Jun 9. Epub 2017 Jun 9.
    From the *University of Maryland Medical System, Baltimore, MD; †Department of Surgery, Drexel University College of Medicine, Philadelphia, PA; and ‡Rothman Institute of Orthopedics; and §The Plastic Surgery Center, The Institute for Advanced Reconstruction, Egg Harbor, NJ.
    Background: Small (<30 cm) soft tissue defects of the distal leg, foot, and ankle pose a complicated issue with regard to wound healing. Multiple flaps have been proposed for reconstruction of these wounds with varying levels of success. The medial femoral condyle flap is a free bone flap supplied by the descending geniculate artery. Read More

    Fibroblast Transplantation Results to the Degenerated Rabbit Lumbar Intervertebral Discs.
    Open Orthop J 2017 17;11:404-416. Epub 2017 May 17.
    Istanbul University, Istanbul Faculty of Medicine, Algology Department, Istanbul, Turkey.
    Background: Our study is an analysis of the histological and radiological changes in degenerated lumbar intervertebral discs, after transplantation of fibroblasts in rabbits. With that study we aimed to show the viability of the fibroblasts injected to the degenerated discs, and observe their potential for further studies.

    Method: The apoptosis of the cell is one of the factors at the disc degeneration process. Read More

    Split thickness skin graft meshing ratio indications and common practices.
    Burns 2017 Jun 8. Epub 2017 Jun 8.
    Division of Plastic Surgery, Department of Surgery, University of British Columbia, Vancouver, BC, Canada; BC Professional Firefighters' Burn Unit, Canada.
    Background: Split thickness skin grafting is a commonly used technique in burn surgery for resurfacing wounds that are unlikely to heal without scarring. Meshing and expanding skin grafts allow for reconstruction of larger wounds with smaller donor sites.

    Methods: A retrospective chart review was performed of 210 patients with burns equal to or greater than 20% total body surface area admitted to Vancouver General Hospital between 1998 and 2014. Read More

    Skin grafts from genetically modified α-1,3-galactosyltransferase knockout miniature swine: A functional equivalent to allografts.
    Burns 2017 Jun 8. Epub 2017 Jun 8.
    TBRC Laboratory, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, USA; Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
    Burn is associated with a considerable burden of morbidity worldwide. Early excision of burned tissue and skin grafting of the resultant wound has been established as a mainstay of modern burn therapy. However, in large burns, donor sites for autologous skin may be limited. Read More

    Surgical management of leukoderma after burn: A review.
    Burns 2017 Jun 8. Epub 2017 Jun 8.
    University of Miami Leonard M. Miller School of Medicine, Department of Dermatology and Cutaneous Surgery, Interdisciplinary Stem Cell Institute, 1501 NW 10th Street, Suite 924, Miami, FL 33136, USA.
    Burns are a common and sometimes devastating injury causing a significant amount of pain, disability, and occasionally death. Burns can have serious aesthetic and functional consequences such as pigmentary changes and formation of scar tissue. Hypopigmentation or depigmentation is often a result of partial- or full-thickness burns, which is referred to as leukoderma after burn. Read More

    Activities of MSCs Derived from Transgenic Mice Seeded on ADM Scaffolds in Wound Healing and Assessment by Advanced Optical Techniques.
    Cell Physiol Biochem 2017 Jun 9;42(2):623-639. Epub 2017 Jun 9.
    MOE Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, China.
    Background/aims: Bone marrow Mesenchymal stem cells (MSCs) are promising for promoting cutaneous wound healing through reinforcing cellular processes. We evaluated the effect of GFP-tagged MSCs transplantation on skin regeneration in excisional wounds in mice.

    Methods: MSCs from GFP-labeled transgenic mice were co-cultured with acellular dermal matrix (ADM) scaffolds, and MSC-ADM scaffolds were transplanted into surgical skin wounds of BALB/c mice. Read More

    Mesenchymal stem cells can induce regulatory T cells via modulating miR-126a but not miR-10a.
    Gene 2017 Jun 18. Epub 2017 Jun 18.
    Department of Biology, Faculty of Science, Razi University, Kermanshah, Iran. Electronic address:
    Among the different immunosuppressive properties attributed to mesenchymal stem cells (MSCs), one relies on their ability to induce regulatory T cells (iTregs) from conventional T cells under particular inflammatory context. Stable Foxp3 expression plays a major role in the phenotypic and functional stability of iTregs. However, the mechanism behind Foxp3 induction in iTregs by MSCs remains unknown. Read More

    Treating pain on skin graft donor sites: review and clinical recommendations.
    J Trauma Acute Care Surg 2017 Jun 9. Epub 2017 Jun 9.
    aDivision of Physical Medicine and Rehabilitation, Departments of Clinical Neurosciences, Pediatrics and Surgery, Faculty of Medicine, University of Calgary, Alberta, Canada. bDepartment of Comparative Biology & Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary. cFaculty of Medicine, University of Calgary, Alberta, Canada. dCalgary Firefighters' Burn Treatment Centre, Canada. eSection of Plastic Surgery, Department of Surgery, University of Calgary, Alberta, Canada.
    Split-thickness skin grafting (STSG) is the most common reconstructive procedure in managing burn injuries. Harvesting split-thickness skin creates a new partial thickness wound referred to as the donor site. Pain at the donor site is reported to be one of the most distressing symptoms during the early post-operative period. Read More

    Long-term diabetes complications after pancreas transplantation.
    Curr Opin Organ Transplant 2017 Jun 8. Epub 2017 Jun 8.
    aDepartment of Transplantation Medicine, Oslo University Hospital, Rikshospitalet bInstitute of Clinical Medicine, University of Oslo, Oslo cMetabolic and Renal Research Group, UiT The Arctic University of Norway, Tromsø, Norway.
    Purpose Of Review: The intention of this study is to summarize present knowledge about adverse effects of hyperglycemia in diabetes, and in this context review more recent data concerning the effects of pancreas transplantation on a wide range of diabetic complications.

    Recent Findings: Effective blood glucose control by insulin delays progression of microvascular complications and probably improves survival in type 1 diabetes. A successful pancreas transplantation combined with a kidney graft has recently been found to prevent diabetic kidney lesions, and registry data support improved long-term patient survival. Read More

    Graft versus host disease: what should the oculoplastic surgeon know?
    Curr Opin Ophthalmol 2017 Jun 8. Epub 2017 Jun 8.
    University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
    Purpose Of Review: To provide a concise review of the oculoplastic manifestations of ocular graft versus host disease (GVHD), and to discuss their management.

    Recent Findings: Ocular GVHD occurs as a common immune-mediated complication of hematopoietic stem cell transplantation that presents as a Stevens-Johnson-like syndrome in the acute phase or a Sjögren-like syndrome in the chronic phase. Cicatricial conjunctivitis may be underreported in ocular GVHD. Read More

    Use of an epidermal growth factor-infused foam dressing in a complicated case of Adams-Oliver syndrome.
    J Wound Care 2017 Jun;26(6):342-345
    Koç University School of Medicine, Department of Plastic, Reconstructive and Aesthetic Surgery, Istanbul, Turkey.
    Adams-Oliver syndrome is a rare disorder with varying degrees of scalp and cranial bone defects as well as limb anomalies, which can range from mild to more pronounced manifestations. In mild cases, closure of these defects can be achieved with a conservative approach. However, surgical closure is recommended in cases where the defect is extensive and includes cranial involvement. Read More

    Failure rates of artificial dermis products in treatment of diabetic foot ulcer: A systematic review and network meta-analysis.
    Wound Repair Regen 2017 Jun 8. Epub 2017 Jun 8.
    Department of Reconstructive and Plastic Surgery, Montpellier, France.
    Diabetic foot ulcer (DFU) is a frequent complication in diabetic patients, occurring in up to 25% of those affected. Among the treatments available to clinicians, the use of bioengineered skin substitutes is an attractive alternative. Artificial dermis functions as a matrix, covering the wound and supporting healing and reconstruction of the lost tissue. Read More

    Safety and efficacy of mogamulizumab in patients with adult T-cell leukemia-lymphoma in Japan: interim results of postmarketing all-case surveillance.
    Int J Hematol 2017 Jun 9. Epub 2017 Jun 9.
    Department of Hematology, National Cancer Center Hospital, Tokyo, Japan.
    We present the interim results of a postmarketing all-case surveillance study in patients with C-C chemokine receptor 4 (CCR4)-positive, relapsed or refractory adult T-cell leukemia-lymphoma (ATL) treated with the anti-CCR4 monoclonal antibody mogamulizumab since its 2012 launch in Japan. The safety and efficacy analysis populations comprised 484 and 442 patients, respectively. The ATL subtype was acute in 58. Read More

    Effects of Fat Grafting Containing Stem Cells in Microstomia and Microcheilia Derived from Systemic Sclerosis.
    Aesthetic Plast Surg 2017 Jun 8. Epub 2017 Jun 8.
    Plastic, Reconstructive and Aesthetic Surgery Clinic, Second University of Naples, Piazza Miraglia, 80138, Naples, Italy.
    Background: Systemic sclerosis (SSc) is an autoimmune disease with multisystem involvement, dominated by a general fibrosis. The early stage of the disease is associated with progressive damage to microcirculation, particularly in the respiratory tract, the gastrointestinal tract and skin. The face assumes a typical appearance characterized by microstomia (reduction of mouth opening) and microcheilia (thinning of the lips). Read More

    Adipose-derived stem cells seeded in Pluronic F-127 hydrogel promotes diabetic wound healing.
    J Surg Res 2017 May 5. Epub 2017 May 5.
    Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China. Electronic address:
    Background: Chronic nonhealing wound is a multifactorial complication of diabetes that results specifically as a consequence of impaired angiogenesis and currently lacks in effective treatments. Although a stem cell-based therapy may provide a novel treatment to augment diabetic wound healing, inferior cell survival at the diabetic skin wound is one of the key causes that are responsible for the low efficacy of the stem cell therapy.

    Materials And Methods: In this work, we used an injectable, biocompatible, and thermosensitive hydrogel Pluronic F-127 to encapsulate allogeneic nondiabetic adipose-derived stem cells (ADSCs) and topically applied the cells to a full-thickness cutaneous wound in the streptozotocin-induced diabetic model in rats. Read More

    Generation of tooth-periodontium complex structures using high-odontogenic potential dental epithelium derived from mouse embryonic stem cells.
    Stem Cell Res Ther 2017 Jun 8;8(1):141. Epub 2017 Jun 8.
    Department of Oral and Maxillofacial Surgery/Central Laboratory, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, 100081, People's Republic of China.
    Background: A number of studies have shown that tooth-like structures can be regenerated using induced pluripotent stem cells and mouse embryonic stem (mES) cells. However, few studies have reported the regeneration of tooth-periodontium complex structures, which are more suitable for clinical tooth transplantation. We established an optimized approach to induce high-odontogenic potential dental epithelium derived from mES cells by temporally controlling bone morphogenic protein 4 (BMP4) function and regenerated tooth-periodontium complex structures in vivo. Read More

    The role of bone marrow mesenchymal stromal cell derivatives in skin wound healing in diabetic mice.
    PLoS One 2017 8;12(6):e0177533. Epub 2017 Jun 8.
    Production Unity of Advanced Therapy, Fundación Ofalmológica de Santander, Clínica Carlos Ardila Lulle (FOSCAL Internacional), Bucaramanga, Colombia.
    Mesenchymal stromal cells (MSCs) have shown to be a promising tool in cell therapies to treat different conditions. Several pre-clinical and clinical studies have proved that the transplantation of MSCs improves wound healing. Here, we compare the beneficial effects of mouse bone marrow-derived allogeneic MSCs (allo-mBM-MSCs) and their acelullar derivatives (allo-acd-mMSCs) on skin wound healing in Non-Obese Diabetic (NOD) mice. Read More

    Thermal burn in a 30-minute-old newborn: report on the youngest patient with iatrogenic burn injury.
    Ann Burns Fire Disasters 2017 Mar;30(1):62-64
    Lebanese Hospital, Beirut, Lebanon.
    Burns in infants are rare. The majority of neonatal burns occur in the hospital setting. The immaturity of their immune system, their fragile and thin skin, difficulties in resuscitation, engraftment paucity limited by donor sites, and long-term complications make taking care of burned newborns extremely difficult. Read More

    Grafting both acute wound site and adjacent donor site with the same graft: an easy and safe procedure to improve healing and minimize pain in elderly and bedridden patients.
    Ann Burns Fire Disasters 2017 Mar;30(1):52-56
    Department of Plastic Surgery and Burn Treatment, Percy Military Hospital, Clamart, France.
    In harvesting skin to cover the defect caused by a burn, a second wound is created, the donor site wound. We propose an alternative method to manage the donor site: taking a split-thickness skin graft (STSG) from a donor site adjacent to the burn wound to be treated, and meshing at a 3:1 ratio to cover both sites at once. The main objective of this study is to evaluate the effectiveness of covering both burn wound and adjacent donor site with the same STSG in elderly and bedridden patients. Read More

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