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    Acute Compartment Syndrome after an Olecranon Fracture in a Patient with Mild Hemophilia B.
    J Orthop Case Rep 2017 Mar-Apr;7(2):98-101
    Department of Orthopedics, Drexel University College of Medicine, Hahnemann University Hospital, United States.
    Introduction: Compartment syndrome is a serious condition characterized by compartmental pressures within 20 mmHg of diastolic blood pressure, or clinical signs of pain, paresthesia, pallor, and lack of pulses. Often a surgical intervention is necessary. Increased surveillance for compartment syndrome is important when a patient with a bleeding disorder sustains a traumatic injury. Read More

    Radius regeneration after open fracture and extrusion: a case report.
    J Pediatr Orthop B 2017 Aug 16. Epub 2017 Aug 16.
    Department of Pediatric Orthopaedic Surgery, Andrews Academic Tower, 3rd floor, 800 Stanton L. Young Blvd, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
    A pediatric patient presenting with an open forearm fracture with segmental defect is rare, and the pediatric orthopedic literature to guide treatment is sparse. There are several described methods to treat the defect, including bone grafting and bone transport techniques. In addition, there are reports of fibular regeneration after resection if the periosteum is left intact. Read More

    ANALYSIS OF SURVIVAL OF ALLOGENEIC FETAL LIVER FRAGMENTS IN RATS.
    Cell Transplant 1995 Jan;4(1):45-47
    The survival of allogeneic fetal liver fragments in the omentum was analyzed in rats. The lymphocyte subsets of the spleen and peripheral blood were also examined. When the fetal liver fragments were transplanted into the omentum, they survived for 2 wk, whereas adult liver fragments survived only 1 wk. Read More

    Establishment of esophagogastric xenografts: A model for characterizing disease heterogeneity.
    J Clin Oncol 2012 Oct;30(30_suppl):95
    Memorial Sloan-Kettering Cancer Center, New York, NY.
    95 Background: Gastric cancer is a heterogeneous disease that may be subdivided into distinct subtypes-proximal/gastroesophageal (GE) junction, diffuse/signet ring type, and distal gastric cancer/intestinal type-based on histopathologic and anatomic criteria. Each subtype is associated with unique epidemiology and gene expression. Human epidermal growth factor receptor (HER2) is a validated treatment target in gastric cancer. Read More

    Development of chemotherapy-induced extravasation management algorithm to facilitate and improve care of cancer patients.
    J Clin Oncol 2014 Oct;32(30_suppl):224
    Mount Sinai Hospital, New York, NY.
    224 Background: Chemotherapy administration has up to a 6% incidence of extravasation, which can cause ulcer formation, tissue necrosis and loss of limb function, requiring surgical intervention (debridement and skin grafting). Because of its rare occurrences and the lack of uniform consensus on management strategies, much time is spent on decision making process by the patient care team and treatments are often delayed. To facilitate and improve the care of cancer patients in cases of chemotherapy extravasation, a task force was created to develop chemotherapy extravasation management algorithm. Read More

    Use of bilayer matrix wound dressing in the exenterated socket.
    Orbit 2017 Aug 16:1-4. Epub 2017 Aug 16.
    a Institute of Ophthalmology and Visual Science , Rutgers New Jersey Medical School , Newark , New Jersey , USA.
    To describe the novel use of a bilayer dermal substitute to reconstruct exenterated orbits. A retrospective chart review was performed in the practices of two surgeons (RET and PDL) of all patients who had undergone orbital exenteration between April 2014 and June 2016 and whose subsequent reconstruction included lining the socket with Integra bilayer. Patient demographics, pathologic diagnoses, surgical and post-operative complications, graft integrity, and patient acceptance were recorded. Read More

    Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing Model.
    J Vis Exp 2017 Aug 4(126). Epub 2017 Aug 4.
    Diabetic Center, Tokyo Women's Medical University School of Medicine.
    Artificial skin has achieved considerable therapeutic results in clinical practice. However, artificial skin treatments for wounds in diabetic patients with impeded blood flow or with large wounds might be prolonged. Cell-based therapies have appeared as a new technique for the treatment of diabetic ulcers, and cell-sheet engineering has improved the efficacy of cell transplantation. Read More

    "Broad-Spectrum Bactericidal Activity of a New Bioactive Grafting Material (F18) Against Clinically Important Bacterial Strains".
    Int J Antimicrob Agents 2017 Aug 11. Epub 2017 Aug 11.
    Department of Morphology and Pathology, Federal University of São Carlos, São Carlos, SP, Brazil.. Electronic address:
    Infection is the most relevant surgical complication in implant or grafting procedures. Osteomyelitis and other chronic conditions pose a constant challenge in the current practice of medicine. In this context, a grafting biomaterial that possesses antibacterial properties combined with bioactivity could have great clinical impact. Read More

    Health characteristics of heart transplant recipients surviving into their 80s.
    J Surg Res 2017 Aug 6;216:99-102. Epub 2017 May 6.
    Division of Cardiothoracic Surgery, Department of Surgery, University of Utah School of Medicine, Salt Lake City, Utah. Electronic address:
    Background: Heart transplantation (HTx) is the preferred treatment for patients with end-stage heart failure and has been successful for >30 y. The clinical course of recipients at the extreme of age is unknown. We reviewed our experience to determine the overall health and prevalence of Tx-related medical problems for recipients in their ninth decade. Read More

    Skin-Limited Graft-versus-Host Disease after Pancreatic Transplantation.
    Case Rep Transplant 2017 18;2017:4823870. Epub 2017 Jul 18.
    Department of Dermatology, Mayo Clinic, Scottsdale, AZ, USA.
    Introduction: The phenomenon of graft-versus-host disease, a solid organ transplant recipient, is a rare development with a very poor prognosis.

    Case Presentation: A 40-year-old woman with type 1 diabetes developed cutaneous graft-versus-host disease following second pancreas transplantation.

    Conclusion: The development of a nonspecific rash in the early posttransplant period following a pancreas transplant warrants suspicion for graft-versus-host disease. Read More

    Acute Beneficial Effects of Muscular Counterpulsation in Patients with Coronary Heart Diseases.
    Int J Angiol 2017 Sep 28;26(3):148-157. Epub 2016 Nov 28.
    Department of Anesthesiology, Bakoulev Scientific Centre for Cardiovascular Surgery, Moscow, Russia.
    This prospective pilot study was designed to investigate the acute hemodynamic effects and clinical applicability of muscular counterpulsation (MCP), a one-shot procedure for biomechanical circulatory support. The study included 17 consecutive patients with coronary artery disease (CAD) and impaired ejection fraction (EF ≤45%) who underwent elective coronary artery bypass grafting (CABG). Patients were divided into control ( n  = 7) and treatment ( n  = 10) groups. Read More

    Isolated severe microblepharon in a neonate: a rare case.
    Int Ophthalmol 2017 Aug 12. Epub 2017 Aug 12.
    Oculoplasty and Ocular Oncology Services, Dr. RP Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.
    Purpose: To report a rare case of isolated severe microblepharon in a neonate.

    Methods: A 27 days old male child was brought by parents with redness, photophobia and discharge for two weeks. Thorough ophthalmological and systemic examination was performed. Read More

    [Urethral centralization and pseudo-glans formation after partial penectomy].
    Urologe A 2017 Aug 11. Epub 2017 Aug 11.
    Department of Urology, University College London Hospitals NHS Foundation Trust, London, Großbritannien.
    The management of penile cancer has altered dramatically over the last decade. Confidence to excise lesions safely with smaller margins has led to the adoption of penile-preserving techniques and in turn improved the functional and cosmetic results. Patients undergoing partial penectomy (PP) find that the urethral meatus is located in an abnormal ventral position. Read More

    Variability in split-thickness skin graft depth when using an air-powered dermatome: A paediatric cohort study.
    Burns 2017 Aug 8. Epub 2017 Aug 8.
    Centre for Children's Burns and Trauma Research, Queensland Children's Medical Research Institute, University of Queensland, Australia; Bond Institute of Health & Sport, Bond University, Queensland, Australia.
    Aim: Split-thickness skin grafts (STSG) taken using calibrated powered dermatomes are assumed to yield a graft of uniform thickness, though this assumption has never been analysed statistically. This study aims to test that assumption in a paediatric population.

    Method: STSGs from a consecutive cohort of paediatric patients were analysed for mean thickness, measured from a central biopsy. Read More

    COL7A1 Editing via CRISPR/Cas9 in Recessive Dystrophic Epidermolysis Bullosa.
    Mol Ther 2017 Jul 13. Epub 2017 Jul 13.
    EB House Austria, Research Program for Molecular Therapy of Genodermatoses, Department of Dermatology, University Hospital of the Paracelsus Medical University, 5020 Salzburg, Austria. Electronic address:
    Designer nucleases allow specific and precise genomic modifications and represent versatile molecular tools for the correction of disease-associated mutations. In this study, we have exploited an ex vivo CRISPR/Cas9-mediated homology-directed repair approach for the correction of a frequent inherited mutation in exon 80 of COL7A1, which impairs type VII collagen expression, causing the severe blistering skin disease recessive dystrophic epidermolysis bullosa. Upon CRISPR/Cas9 treatment of patient-derived keratinocytes, using either the wild-type Cas9 or D10A nickase, corrected single-cell clones expressed and secreted similar levels of type VII collagen as control keratinocytes. Read More

    Self-organization process in newborn skin organoid formation inspires strategy to restore hair regeneration of adult cells.
    Proc Natl Acad Sci U S A 2017 Aug 10. Epub 2017 Aug 10.
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033;
    Organoids made from dissociated progenitor cells undergo tissue-like organization. This in vitro self-organization process is not identical to embryonic organ formation, but it achieves a similar phenotype in vivo. This implies genetic codes do not specify morphology directly; instead, complex tissue architectures may be achieved through several intermediate layers of cross talk between genetic information and biophysical processes. Read More

    The Immune Reconstitution of the Skin Following Sex Mismatched Allogeneic Hematopoietic Stem Cell Transplant: A prospective case series utilizing fluorescent in situ hybridization and immunohistochemistry.
    Br J Dermatol 2017 Aug 10. Epub 2017 Aug 10.
    University of Pennsylvania, Departments of Dermatology and Pathology.
    Graft versus host disease (GVHD) is a common, morbid, and potentially fatal complication of allogeneic hematopoietic stem cell transplantation (aHSCT).(1-3) The exact timing of the arrival of donor-derived immune cells and their profile in the skin have not been well described in humans.(4-6) Fluorescent in situ hybridization (FISH) is a technique that has been used to distinguish host versus donor-derived immune cells in patients who have undergone sex-mismatched aHSCT. Read More

    Results of directly applied activated carbon cloth in chronic wounds: a preliminary study.
    J Wound Care 2017 Aug;26(8):476-481
    Department of Surgery, Limmattal Hospital, Zurich-Schlieren, Switzerland.
    Objective: Activated carbon (AC) has been used in wound therapy as an active substance inside dressings. Applying AC directly on a wound is a new concept. The aim of this study was to analyse the outcomes of chronic wounds which were managed with directly applied activated carbon knitted cloth (ACC, Zorflex) in Swiss patients. Read More

    Comparison of the Results of Early Excision and Grafting between Children and Adults; A Prospective Comparative Study.
    Bull Emerg Trauma 2017 Jul;5(3):179-183
    Amiralmomenin Hospital, Burn and wound healing research center, Department of Surgery, Shiraz University of Medical Science, Shiraz, Iran.
    Objectives: To compare the outcomes of early excision and grafting between pediatric and adult patients with deep burns of less than 40% total body surface area burns (TBSA).

    Methods: This is a prospective comparative study. Overall, 106 patients admitted to Ghotbodin Burn Center in Shiraz, Iran from September 2012 to September 2013, were included in the study. Read More

    The effect of full dose composite tissue allotransplantation immunosuppression on allograft motor nerve regeneration in a rat sciatic nerve model.
    Microsurgery 2017 Aug 9. Epub 2017 Aug 9.
    Microvascular Research Laboratory, Mayo Clinic, Rochester, Minnesota.
    Background: The purpose of this study was to identify which triple immunosuppressive protocols, currently used for vascularized composite allotransplantation in the clinic, will have the best effect on motor function recovery following nerve allograft reconstruction.

    Methods: Eighty-eight Lewis rats underwent a 1-cm sciatic nerve allograft transplantation and skin graft from 44 Brown-Norway rats. Group I received 0. Read More

    Binder syndrome: Clinical findings and surgical treatment of 18 patients at the Department of Plastic Surgery in Polanica Zdrój.
    Adv Clin Exp Med 2017 May-Jun;26(3):427-437
    Plastic Surgery Unit, Specialist Medical Centre, Polanica Zdrój, Poland.
    Background: Binder syndrome (BS) is an uncommon congenital underdevelopment of the maxilla and nasal skeleton. Other clinical features include a hypoplastic or absent anterior nasal spine; a short, flat nose with short columella; an acute nasolabial angle; a convex upper lip and class III malocclusion.

    Objectives: The aim of the study was to outline the major characteristics of BS and to present a variety of surgical treatment methods. Read More

    Establishment of a murine pancreatic cancer pain model and microarray analysis of pain‑associated genes in the spinal cord dorsal horn.
    Mol Med Rep 2017 Aug 4. Epub 2017 Aug 4.
    Department of Anesthesiology and Intensive Care Unit, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, P.R. China.
    There is emerging evidence on the mechanisms of pancreatic cancer pain. Following the establishment of an orthotropic transplantation model of pancreatic cancer, microarray analysis was performed to identify changes in the expression levels of pain‑associated genes in the spinal cord. A mouse model of pancreatic cancer‑induced pain was established by implanting SW 1990 cells into the pancreases of female BALB/c‑nu mice. Read More

    Prospective Study of a Cohort of Russian Nijmegen Breakage Syndrome Patients Demonstrating Predictive Value of Low Kappa-Deleting Recombination Excision Circle (KREC) Numbers and Beneficial Effect of Hematopoietic Stem Cell Transplantation (HSCT).
    Front Immunol 2017 24;8:807. Epub 2017 Jul 24.
    Dmitry Rogachev National Research and Clinical Center for Pediatric Hematology, Oncology and Immunology, Moscow, Russia.
    Background: Nijmegen breakage syndrome (NBS) is a combined primary immunodeficiency with DNA repair defect, microcephaly, and other phenotypical features. It predominantly occurs in Slavic populations that have a high frequency of carriers with the causative NBN gene c.657_661del5 mutation. Read More

    Early ambulation after-grafting of lower extremity burns.
    Burns 2017 Aug 5. Epub 2017 Aug 5.
    Manitoba Firefighters' Burn Unit, Winnipeg, Manitoba, Canada; Department of Surgery, Section of Plastic Surgery, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada; Department of Surgery and Children's Health, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address:
    Objective: Early ambulation of lower extremity burns that undergo a skin graft may help to avoid some of the complications associated with immobilization. Despite recent evidence supporting early ambulation, post-operative immobilization following lower extremity skin grafting is still a common practice. The purpose of this study was to retrospectively assess the outcomes of lower extremity skin graft cases dressed with a multi-layer compression bandage who were ambulated in the immediate post-operative period. Read More

    Appearance of New Cutaneous Superficial Basal Cell Carcinomas during Successful Nivolumab Treatment of Refractory Metastatic Disease: Implications for Immunotherapy in Early Versus Late Disease.
    Int J Mol Sci 2017 Jul 31;18(8). Epub 2017 Jul 31.
    Department of Medicine, Division of Hematology/Oncology, University of California San Diego, La Jolla, CA 92093, USA.
    Metastatic basal cell carcinoma may be treated with hedgehog pathway inhibitors, including vismodegib and sonidegib. However, patients can demonstrate resistance to these agents. We describe a man with metastatic basal cell carcinoma who did not respond well to vismodegib and sonidegib. Read More

    Scalping Surgery - Dermatologic Indications beyond Curative Primary Skin Cancer Surgery.
    Open Access Maced J Med Sci 2017 Jul 19;5(4):414-419. Epub 2017 Jul 19.
    Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior, and Onkoderma Policlinic for Dermatology and Dermatologic Surgery, Sofia, Bulgaria.
    Skin tumours are among the most frequent tumour types of mankind. In the case of large tumours, field cancerization, or satellitosis scalping surgery is a possible option. The procedure can also be used in a palliative setting with tumour debulking. Read More

    Human lymphoid organ dendritic cell identity is predominantly dictated by ontogeny, not tissue microenvironment.
    Sci Immunol 2016 Dec 16;1(6). Epub 2016 Dec 16.
    Department of Dermatology, Laboratory of Dendritic Cell Biology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), University Hospital Erlangen, Erlangen, Germany.
    In mice, conventional and plasmacytoid dendritic cells (DCs) derive from separate hematopoietic precursors before they migrate to peripheral tissues. Moreover, two classes of conventional DCs (cDC1 and cDC2 DCs) and one class of plasmacytoid DCs (pDCs) have been shown to be transcriptionally and functionally distinct entities. In humans, these three DC subtypes can be identified using the cell surface markers CD1c (cDC2), CD141 (cDC1), and CD303 (pDCs), albeit it remains elusive whether DC functionality is mainly determined by ontogeny or the tissue microenvironment. Read More

    Donor exosomes rather than passenger leukocytes initiate alloreactive T cell responses after transplantation.
    Sci Immunol 2016 Jul 23;1(1):aaf8759. Epub 2016 Jun 23.
    Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
    Transplantation of allogeneic organs and tissues represents a lifesaving procedure for a variety of patients affected with end-stage diseases. Although current immunosuppressive therapy prevents early acute rejection, it is associated with nephrotoxicity and increased risks for infection and neoplasia. This stresses the need for selective immune-based therapies relying on manipulation of lymphocyte recognition of donor antigens. Read More

    Effect of voriconazole on risk of nonmelanoma skin cancer after hematopoietic cell transplantation.
    J Am Acad Dermatol 2017 Aug 2. Epub 2017 Aug 2.
    Department of Dermatology, Stanford University School of Medicine, Stanford, California. Electronic address:
    Background: Voriconazole has previously been associated with increased risk for cutaneous squamous cell carcinoma (SCC) in solid organ transplant recipients. Less is known about the risk in patients after hematopoietic cell transplantation (HCT).

    Objective: We evaluated the effect of voriconazole on the risk for nonmelanoma skin cancer (NMSC), including SCC and basal cell carcionoma, among those who have undergone allogeneic and autologous HCT. Read More

    'Reverse expansion': A new technique of breast reconstruction with autologous tissue.
    J Plast Reconstr Aesthet Surg 2017 Jul 18. Epub 2017 Jul 18.
    Breast and General Surgery Unit, "A. Franchini" Hospital, Via Pedrignone 3, Santarcangelo di Romagna, Italy.
    The treatment for breast cancer is sometimes long and requires a multidisciplinary approach. In 2010, in our centre, we began to perform fat grafting for breast reconstruction using the so-called 'reverse expansion' technique. This consists of the insertion of a skin expander during mastectomy, in its expansion and then in its gradual deflation in the surgical theatre during fat grafting. Read More

    Vulvovaginal Graft-Versus-Host Disease.
    Obstet Gynecol Clin North Am 2017 Sep;44(3):475-492
    UCSF School of Medicine, 505 Parnassus Avenue, San Francisco, CA 94143, USA.
    Vulvovaginal chronic graft-versus-host disease (cGVHD) is an underrecognized complication of stem cell transplantation. Early recognition may prevent severe sequelae. Genital involvement is associated with oral, ocular, and skin manifestations. Read More

    Mesenchymal Stem Cells in Fibrotic Disease.
    Cell Stem Cell 2017 Aug;21(2):166-177
    Institute of Life Sciences, Wenzhou University, Wenzhou University-Wenzhou Medical University Collaborative Innovation Center of Biomedicine, Wenzhou, Zhejiang, China; Excellence Cluster Cardio-Pulmonary System (ECCPS), Universities of Giessen and Marburg Lung Center (UGMLC), Justus-Liebig-University Giessen, German Center for Lung Research (DZL), Giessen, Germany. Electronic address:
    Fibrosis is associated with organ failure and high mortality and is commonly characterized by aberrant myofibroblast accumulation. Investigating the cellular origin of myofibroblasts in various diseases is thus a promising strategy for developing targeted anti-fibrotic treatments. Recent studies using genetic lineage tracing technology have implicated diverse organ-resident perivascular mesenchymal stem cell (MSC)-like cells and bone marrow-MSCs in myofibroblast generation during fibrosis development. Read More

    Rapamycin prolongs graft survival and induces CD4+IFN-γ+IL-10+ regulatory type 1 cells in old recipient mice.
    Transplantation 2017 Aug 2. Epub 2017 Aug 2.
    aTransplant Surgery Research Laboratory and Division of Transplant Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, USA bDepartment of General, Visceral and Transplant Surgery, Tuebingen University Hospital, Tuebingen, Germany cDepartment of Nephrology, Charité Campus Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany dDepartment of Surgery, University Hospital Regensburg, Regensburg, Germany eDepartment of Urology, Osaka Medical College, Osaka, Japan fTransplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
    Background: Although the elderly represents a rapidly growing population among transplant recipients, age-specific aspects have not been considered sufficiently in clinical trials. Moreover, age-specific effects of immunosuppressive therapies remain poorly understood.

    Methods: Here, we assessed the impact of Rapamycin on alloimmune responses in old recipients using a fully MHC-mismatched murine transplantation model. Read More

    Solid Organ Transplant-Transmitted Tuberculosis Linked to a Community Outbreak - California, 2015.
    MMWR Morb Mortal Wkly Rep 2017 Aug 4;66(30):801-805. Epub 2017 Aug 4.
    In the spring of 2015, a local health department (LHD) in county A notified the California Department of Public Health (CDPH) about three adults with close ties to one another and a congregate community site who had received diagnoses of tuberculosis (TB) disease within a 3-month period. Subsequent review revealed matching TB genotypes indicating that the cases were likely part of a chain of TB transmission. Only three TB cases in California in the preceding 2 years shared this same genotype. Read More

    Validation of a Simple Scoring System to Predict Sorafenib Effectiveness in Patients with Hepatocellular Carcinoma.
    Target Oncol 2017 Aug 3. Epub 2017 Aug 3.
    Department of Transplantation - Liver Unit, Cardarelli Hospital, via A. Cardarelli 9, 80131, Naples, Italy.
    Background: Sorafenib is recommended for the treatment of advanced-stage hepatocellular carcinoma (HCC). Nonetheless, it is expensive, effective in few patients, and may cause significant adverse effects. Therefore, accurate selection of patients is needed. Read More

    Anti-Interleukin-6 Promotes Allogeneic Bone Marrow Engraftment and Prolonged Graft Survival in an Irradiation-Free Murine Transplant Model.
    Front Immunol 2017 19;8:821. Epub 2017 Jul 19.
    Department of Surgery, Section of Transplant Immunology, Medical University of Vienna, Vienna, Austria.
    Transfer of recipient regulatory T cells (Tregs) induces mixed chimerism and tolerance in an irradiation-free bone marrow (BM) transplantation (BMT) model involving short-course co-stimulation blockade and mTOR inhibition. Boosting endogenous Tregs pharmacologically in vivo would be an attractive alternative avoiding the current limitations of performing adoptive cell therapy in the routine clinical setting. Interleukin-6 (IL-6) potently inhibits Treg differentiation and its blockade was shown to increase Treg numbers in vivo. Read More

    The possibility of free tissue transfer as a nutrient flap for critical ischemic foot: A case report.
    Microsurgery 2017 Aug 2. Epub 2017 Aug 2.
    Department of Plastic and Reconstructive Surgery, Graduate School of Medical Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
    Microsurgical procedure of free tissue transfer in critical limb ischemia patients with large ulceration has already been established. The nutrient flap concept was that transferred tissue functioned not only to cover the skin defect but also as a supplementary blood supply to the ischemic lower leg. This report showed the justification for this concept, which was rarely discussed. Read More

    Intrapancreatic Parenchymal Injection of Cells as a Useful Tool for Allowing a Small Number of Proliferative Cells to Grow In Vivo.
    Int J Mol Sci 2017 Aug 2;18(8). Epub 2017 Aug 2.
    Department of Pediatric Dentistry, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan.
    In vivo inoculation of cells such as tumor cells and induced pluripotent stem (iPS)/embryonic stem (ES) cells into immunocompromised mice has been considered as a powerful technique to evaluate their potential to proliferate or differentiate into various cell types originating from three germ cell layers. Subcutaneous grafting and grafting under the kidney capsule have been widely used for this purpose, but there are some demerits such as the requirement of a large number of tumor cells for inoculation and frequent failure of tumorigenesis. Therefore, grafting into other sites has been explored, including intratesticular or intramuscular grafting as well as grafting into the cochleae, liver, or salivary glands. Read More

    iNKT cell activation plus T-cell transfer establishes complete chimerism in a murine sublethal bone marrow transplant model.
    Am J Transplant 2017 Aug 2. Epub 2017 Aug 2.
    Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.
    Transplant tolerance induction makes it possible to preserve functional grafts for a lifetime without immunosuppressants. One powerful method is to generate mixed hematopoietic chimeras in recipients by adoptive transfer of donor-derived bone marrow cells (BMCs). In our murine transplantation model, we established a novel method for mixed chimera generation using sublethal irradiation, CD40-CD40L blockade, and invariant natural killer T-cell activation. Read More

    Atraumatic Acute Compartment Syndrome of Forearm Following Artificial Mehndi (Henna) Dermatitis - A Rare Case Report.
    J Clin Diagn Res 2017 Jun 1;11(6):RD01-RD03. Epub 2017 Jun 1.
    Senior Resident, Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, India.
    Atraumatic compartment syndrome of the forearm is a rare entity. There are several papers available in the literature on the adverse effects of mehndi application; however Acute Compartment Syndrome (ACS) following mehndi application has never been reported. We present the case of a 25-year-old female, who presented with sudden onset swelling and pain in the left forearm. Read More

    [Ribeiro-Technique in Gigantomastia - Review of 294 Reduction Mammaplasties in 8 Years].
    Handchir Mikrochir Plast Chir 2017 Aug 1. Epub 2017 Aug 1.
    Introduction Reduction mammaplasty in patients with gigantomastia is challenging even to very experienced plastic surgeons. Extremely elongated pedicles impair the vascular supply of the nipple-areola complex. Breast shaping and effective reduction are difficult due to the severely stretched skin envelope. Read More

    Immunosuppression maintenance in vascularized composite allotransplantation: what is just right?
    Curr Opin Organ Transplant 2017 Jul 28. Epub 2017 Jul 28.
    aDepartment of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine bDepartment of Surgery, Division of Hepatobiliary Surgery and Transplantation, University of Louisville cTrager Transplant Center, Jewish Hospital, Louisville, Kentucky, USA.
    Purpose Of Review: Over the last two decades advances in vascularized composite allotransplantation have achieved clinically significant milestones. This review provides a synopsis for immunosuppressive maintenance therapy for VCA and discusses the nuances surrounding the determination of the right amount of immunosuppression in vascularized composite allotransplantation.

    Recent Findings: Functional results after vascularized composite allotransplantation remain highly encouraging as are the immunologic outcomes, however, challenges persist. Read More

    Effects of early combinatorial treatment of autologous split-thickness skin grafts in red duroc pig model using pulsed dye laser and fractional CO2 laser.
    Lasers Surg Med 2017 Jul 31. Epub 2017 Jul 31.
    Department of Materials Science and Engineering, The Ohio State University, Columbus, Ohio.
    Background And Objective: The use of pulsed dye laser (PDL) and fractional CO2 (FX CO2 ) laser therapy to treat and/or prevent scarring following burn injury is becoming more widespread with a number of studies reporting reduction in scar erythema and pruritus following treatment with lasers. While the majority of studies report positive outcomes following PDL or FX CO2 therapy, a number of studies have reported no benefit or worsening of the scar following treatment. The objective of this study was to directly compare the efficacy of PDL, FX CO2 , and PDL + FX CO2 laser therapy in reducing scarring post burn injury and autografting in a standardized animal model. Read More

    Cytokine Profiles of Pre-Engraftment Syndrome after Single-Unit Cord Blood Transplantation for Adult Patients.
    Biol Blood Marrow Transplant 2017 Jul 26. Epub 2017 Jul 26.
    Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
    Clinical manifestation of high grade fever and skin rash prior to neutrophil engraftment, which is called pre-engraftment syndrome (PES) or pre-engraftment immune reaction, has been frequently observed after cord blood transplantation (CBT). The pathophysiology of PES is poorly understood, but cytokine storm during the early phase of CBT is thought to be one of the main cause of PES. However, the cytokine profiles of PES after CBT are unclear. Read More

    Immediate emergency free anterolateral thigh flap after car-tyre friction injury: A case report with eight years follow-up.
    Int J Surg Case Rep 2017 19;38:102-106. Epub 2017 Jul 19.
    Ankara University, School of Medicine, Ibn-i Sina Hospital, Department of Orthopedics, Division of Hand Surgery, Turkey.
    The car-tyre friction injury has differences from other injuries. The components of injury which are burn, crushing, shearing, and degloving occur. Many treatment options can be performed for coverage of wound which are Vacuum Assisted Closure system (V. Read More

    A review of late complications of allogeneic hematopoietic stem cell transplantations.
    Clin Transplant 2017 Jul 28. Epub 2017 Jul 28.
    Department of Hematology, Ankara University Medical School, Cebeci, 06590, Ankara, Turkey.
    Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective and curative treament of different malignant and nonmalignant diseases. Early transplant-related mortality after allo-HSCT has decreased with reduced-intensity conditioning regimens and effective anti-infectious treatments, but late transplant related mortality is still a problem. Physicians are now paying more attention to late complications that may worsen the quality of life of many transplant recipients. Read More

    Y-27632 simplifies the isolation procedure of human primary epidermal cells by selectively blocking focal adhesion of dermal cells.
    J Tissue Eng Regen Med 2017 Jul 27. Epub 2017 Jul 27.
    Laboratory for Tissue Engineering and Regeneration, School of Stomatology, Shandong University, Jinan, Shandong, China.
    Primary skin epidermal cells isolation and in vitro expansion culture has been widely used for laboratory research and clinical applications. The conventional methods involving sequential enzymatic digestion of adult tissues have given low cell recovery rate and reduced cell viability. We report here an advanced method for human primary epidermal progenitor cells isolation from skin tissues including the Rho kinase inhibitor Y-27632. Read More

    Dermal Substitutes Use in Reconstructive Surgery for Skin Tumors: A Single-Center Experience.
    Int J Surg Oncol 2017 2;2017:9805980. Epub 2017 Jul 2.
    Skin Cancer Department, AC Camargo Cancer Center, São Paulo, SP, Brazil.
    Reconstructive surgery following skin tumor resection can be challenging. Treatment options after removing the tumor are skin grafting, local pedicled and axial flaps, or microsurgery for complex and extensive wounds correction. Recently, the use of dermal substitutes has been extended to reconstructive surgery in cutaneous oncology. Read More

    Functional pectoralis minor myocutaneous flap transplantation for reconstruction of thumb opposition: An anatomic study with clinical applications.
    Asian J Surg 2017 Jul 24. Epub 2017 Jul 24.
    Hand and Microvascular Surgery Department, Shenzhen People's Hospital, The 2nd Affiliated Hospital of Jinan University, Shenzhen, Guangdong, People's Republic of China.
    Objective: To develop a myocutaneous flap for reconstruction of thumb opposition function in patients with loss of the thenar muscles and skin.

    Methods: An anatomic experiment on the dimensions of the pectoralis minor muscle and its neurovascular supply in 10 adult human cadavers was conducted to evaluate the feasibility of microsurgical transplantation using part of the muscle for thumb opposition reconstruction. Based on these results, we performed surgical thenar reconstruction with a pectoralis minor myocutaneous flap in seven patients (34. Read More

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