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    Long-term scar quality after hydrosurgical versus conventional debridement of deep dermal burns (HyCon trial): study protocol for a randomized controlled trial.
    Trials 2018 Apr 19;19(1):239. Epub 2018 Apr 19.
    Burn Center, Maasstad Hospital, Rotterdam, the Netherlands.
    Background: Deep dermal burns require tangential excision of non-viable tissue and skin grafting to improve wound healing and burn-scar quality. Tangential excision is conventionally performed with a knife, but during the last decade hydrosurgery has become popular as a new tool for tangential excision. Hydrosurgery is generally thought to be a more precise and controlled manner of burn debridement leading to preservation of viable tissue and, therefore, better scar quality. Read More

    Impact of graft thickness reduction of left lateral segment on outcomes following pediatric living donor liver transplantation.
    Am J Transplant 2018 Apr 19. Epub 2018 Apr 19.
    Organ Transplantation Center, National Center for Child Health and Development, Tokyo, Japan.
    Reducing graft thickness is essential to prevent large-for-size graft problems in pediatric living donor liver transplantation (LDLT). However, long-term outcomes of LDLT using reduced-thickness left lateral segment (LLS) grafts are unclear. In 89 patients who underwent LDLT using reduced LLS grafts between 2005 and 2017, short-term and long-term outcomes were compared between a non-anatomically reduced LLS (NAR-LLS) graft group and a reduced-thickness LLS graft group. Read More

    D816V Positive Acute Mast Cell Leukemia Associated with Normal Karyotype Acute Myeloid Leukemia.
    Case Rep Hematol 2018 18;2018:3890361. Epub 2018 Feb 18.
    Serviço de Hematologia Clínica, Hospital de Santo António (HSA), Centro Hospitalar do Porto (CHP), Porto, Portugal.
    Introduction: Mast cell (MC) leukemia (MCL) is extremely rare. We present a case of MCL diagnosed concomitantly with acute myeloblastic leukemia (AML).

    Case Report: A 41-year-old woman presented with asthenia, anorexia, fever, epigastralgia, and diarrhea. Read More

    Homeostatic proliferation leads to telomere attrition and increased PD-1 expression after autologous hematopoietic SCT for systemic sclerosis.
    Bone Marrow Transplant 2018 Apr 18. Epub 2018 Apr 18.
    Basic and Applied Immunology Program, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
    In the months that follow autologous hematopoietic stem cell transplantation (AHSCT), lymphopenia drives homeostatic proliferation, leading to oligoclonal expansion of residual cells. Here we evaluated how replicative senescent and exhausted cells associated with clinical outcomes of 25 systemic sclerosis (SSc) patients who underwent AHSCT. Patients were clinically monitored for skin (modified Rodnan's skin score, mRSS) and internal organ involvement and had blood samples collected before and semiannually, until 3 years post-AHSCT, for quantification of telomere length, CD8CD28 and PD-1 cells, and serum cytokines. Read More

    Establishment of protocol for preparation of gene-edited bovine ear-derived fibroblasts for somatic cell nuclear transplantation.
    Biomed Res 2018 ;39(2):95-104
    Department of Veterinary Medicine, School of Veterinary Medicine, Rakuno Gakuen University.
    Recently, gene-editing using the clustered regularly interspaced short palindromic repeats (CRISPR)/ CRISPR-associated protein 9 (Cas9) technique has attempted to utilize fibroblasts of livestock animals for somatic cell nuclear transfer. In this study, we establish the procedure for preparing skin fibroblast clones whose genes were edited by the CRISPR/Cas9 technique. After isolating fibroblasts from earlobes of Japanese Black cattle, subsequent collagenase-digestion and extensive wash procedures enabled us to avoid contamination of fungi. Read More

    Efficacy of a gel containing polihexanide and betaine in deep partial and full thickness burns requiring split-thickness skin grafts: A non-comparative clinical study.
    J Burn Care Res 2018 Apr 14. Epub 2018 Apr 14.
    Department of Plastic and Hand Surgery, UniversityCenter for Orthopaedics and Trauma Surgery, Universitätsklinikum Carl Gustav Carus Dresden, Dresden, Germany.
    Background: Despite overall advances in burn therapy, wound infection remains one of the leading causes of morbidity and mortality in patients with severe burn injuries. This prospective, multicenter, non-comparative clinical trial was conducted to assess the efficacy and safety of Prontosan® Wound Gel X (PWX), a gel containing polihexanide and betaine, for moistening and cleansing in deep tissue burn wounds requiring split-thickness skin grafting.

    Methods: Patients with deep partial or full thickness burn wounds requiring split-thickness skin grafting were treated with the gel to evaluate its tolerability and safety as well as graft take and the healing of the skin graft. Read More

    Skin Graft Fixation Using Hydrofiber (Aquacel® Extra).
    Ann Plast Surg 2018 Apr 17. Epub 2018 Apr 17.
    Background: The traditional method of skin graft fixation is with tie-over bollus dressing. The use of splints in the extremities for skin graft fixation is a common practice. However, these splints are heavy and uncomfortable and contribute considerably to our overall medical waste. Read More

    Vitiligo type cutaneous manifestation of chronic graft-versus-host disease. Case report.
    Rev Chil Pediatr 2018 Feb;89(1):113-117
    Departamento de Anatomía Patológica, Hospital Dr. Luis Calvo Mackenna, Santiago, Chile.
    Introduction: Graft-versus-host disease (GVHD) is caused by a pathologic and destructive response of the organism as a result of the interaction between donor immunocompetent T lymphocytes and the recipient tisular antigens. It's considered the most serious complication of hematopoietic stem cell transplantation, most frequently described after bone marrow transplantation (BMT). The skin is usually the first and most commonly affected organ, in both acute and chronic, with a variable clinical spectrum of presentation. Read More

    Hand Assisted Laparoscopic Retroperitoneal Donor Nephrectomy: A Single Institution Experience of Over 500 Cases - Operative Technique and Clinical Outcomes.
    Clin Transplant 2018 Apr 17:e13261. Epub 2018 Apr 17.
    Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts.
    Objective: Although there are several variations of laparoscopic living donor nephrectomies, there is no consensus as to the best technique. Our objective was to describe our technique and assess the outcomes of our approach to hand-assisted laparoscopic retroperitoneal donor nephrectomies.

    Methods: From July 2001 to October 2015, 507 consecutive hand-assisted laparoscopic retroperitoneal donor nephrectomies were performed. Read More

    Effect of skin graft thickness on scar development in a porcine burn model.
    Burns 2018 Apr 13. Epub 2018 Apr 13.
    Department of Materials Science and Engineering, The Ohio State University, Columbus, OH, United States; Department of Biomedical Engineering, The Ohio State University, Columbus, OH, United States. Electronic address:
    Animal models provide a way to investigate scar therapies in a controlled environment. It is necessary to produce uniform, reproducible scars with high anatomic and biologic similarity to human scars to better evaluate the efficacy of treatment strategies and to develop new treatments. In this study, scar development and maturation were assessed in a porcine full-thickness burn model with immediate excision and split-thickness autograft coverage. Read More

    Clinical Profile of Patients With Diabetes Mellitus and Liver Transplantation: Results After a Multidisciplinary Team Intervention.
    Transplant Proc 2018 Apr;50(3):784-787
    Surgery Department, Faculty of Medical Sciences, University of Campinas, Campinas, Sao Paulo, Brazil.
    Background: Over the years, survival after liver transplantation has increased and metabolic complications are becoming more common, contributing to patients' morbidity and mortality. The objectives of this study were to describe a population of patients with hepatic transplantation and diabetes mellitus (DM), evaluate the frequency of metabolic complications, and assess the impact of a multidisciplinary team on DM management.

    Materials And Methods: This was a retrospective study involving interview and medical record analysis of 46 consecutive patients followed at the diabetes mellitus and liver transplantation unit of a tertiary university hospital, all evaluated by a multidisciplinary team. Read More

    Early initiation of extracorporeal photochemotherapy increases response for chronic graft versus host disease following steroid failure.
    Transfus Clin Biol 2018 Apr 11. Epub 2018 Apr 11.
    Department of Hematology, Ankara University Medical School, Ankara, Turkey.
    Objectives: Chronic graft versus host disease (GVHD) is one of the major obstacles to achieve success in allogeneic hematopoietic stem cell transplantation (allo-HSCT). Extracorporeal photochemotherapy (ECP) has been demonstrated to be an effective modality for the treatment of GVHD in previous studies but they vary in terms of initiation and duration. Our aim is to demonstrate the characteristics of our patients who received ECP for chronic GVHD to clarify the best treatment scheme. Read More

    Mini-incision versus hand-assisted laparoscopic donor nephrectomy in living-donor kidney transplantation: A retrospective cohort study.
    Int J Surg 2018 Apr 11;53:339-344. Epub 2018 Apr 11.
    Transplant Outcomes Research, Department of General Surgery, Section of Abdominal Organ Transplant, Washington University in Saint Louis, 660 S. Euclid Ave, Campus Box 8109, Saint Louis, MO, 63110, United States. Electronic address:
    Background: Increasing use of Living Donor Kidney Transplantation (LDKT) would decrease the discrepancy between patients awaiting transplantation and organ availability. Minimally invasive surgical approaches attempt to improve outcomes and foster living donation. This report compares outcomes of open minimal incision nephrectomy (Mini N) and a hand assisted laparoscopic nephrectomy (HALN). Read More

    Adipose mesenchymal stem cell-derived exosomes stimulated by hydrogen peroxide enhanced skin flap recovery in ischemia-reperfusion injury.
    Biochem Biophys Res Commun 2018 Apr 14. Epub 2018 Apr 14.
    Department of Plastic and Reconstructive Surgery, PLA General Hospital, Beijing 100853, PR China. Electronic address:
    Background: Mesenchymal stem cell (MSC)-derived exosomes have been recognized as new candidates for the treatment of ischemic disease or injury and may be an alternative treatment for cell therapy. This aim of the study was to evaluate whether exosomes derived from adipose mesenchymal stem cell (ADSC) can protect the skin flap during ischemia-reperfusion (I/R) injury and induce neovascularization.

    Methods: To investigate the effects of exosomes in the I/R injury of flap transplantation in vivo, flaps were subjected to 6 h of ischemia by ligating the left superficial inferior epigastric vessels (SIEA) followed by blood perfusion. Read More

    [Deep alkali burns: Evaluation of a two-step surgical strategy].
    Ann Chir Plast Esthet 2018 Apr 10. Epub 2018 Apr 10.
    Service de chirurgie plastique, reconstructrice et esthétique, centre de traitement des brûlures, hôpital R. Salengro, CHU de Lille, 59000 Lille, France.
    Introduction: Chemical burns are rare but often lead to deep cutaneous lesions. Alkali agents have a deep and long lasting penetrating power, causing burns that evolve over several days. The local treatment for these patients is excision of the wound and split thickness skin graft. Read More

    Impact of Regulatory T Cells on Innate Immune Cells in a Pre-Sensitized Heart Transplant Model.
    Ann Transplant 2018 Apr 13;23:246-251. Epub 2018 Apr 13.
    Department of Cardiac Surgery, Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China (mainland).
    BACKGROUND Although our previous studies revealed the role of Tregs (regulatory T cells) and MDSCs (myeloid-derived suppressor cells) in a pre-sensitized cardiac transplant model, interplay between Tregs and NK cells, neutrophils, and macrophages remain undefined. MATERIAL AND METHODS Mice heart transplantation with skin pre-sensitization was performed, in which prolonged-cold ischemia time (PCI) was used for donor treatment. Syngeneic heterotopic heart transplant recipients with PCI were treated with PC61 (monoclonal anti-CD25 antibodies), adoptive cell transfer with Tregs, and rapamycin. Read More

    Does Simultaneous Liposuction Adversely Affect the Outcome of Thread Lifts? A Preliminary Result.
    Aesthetic Plast Surg 2018 Apr 11. Epub 2018 Apr 11.
    Department of Plastic and Reconstructive Surgery, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam, Gyeonggi, 13496, Republic of Korea.
    Background: Along with advances in thread lift techniques and materials, ancillary procedures such as fat grafting, liposuction, or filler injections have been performed simultaneously. Some surgeons think that these ancillary procedures might affect the aesthetic outcomes of thread lifting possibly due to inadvertent injury to threads or loosening of soft tissue via passing the cannula in the surgical plane of the thread lifts. The purpose of the current study is to determine the effect of such ancillary procedures on the outcome of thread lifts in the human and cadaveric setting. Read More

    The extra-tunical grafting procedure for Peyronie's disease hourglass and indent deformities.
    Transl Androl Urol 2018 Mar;7(Suppl 1):S1-S6
    Department of Urology, University of California, San Francisco, CA, USA.
    Background: To describe a novel, tunica-sparing surgical technique-extra-tunical grafting (ETG)-for the treatment of penile indent and hourglass (HG) deformities and to describe patient-reported outcomes after the ETG procedure.

    Methods: An IRB-approved, retrospective chart review of ETG patients was performed to collect data including pre-operative deformity, operation performed, and post-operative patient-reported perception of deformity, erectile function, penile sensation, and overall satisfaction with the ETG operation. The indications for surgery were difficulty with sexual intercourse due to deformity and/or poor cosmesis of the penis. Read More

    [Efficacy of dermal scaffold for promoting repair of acute full-thickness skin defects in pigs].
    Nan Fang Yi Ke Da Xue Xue Bao 2018 Mar;38(3):363-368
    Department of Burns, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. E-mail:
    Objective: To investigate the efficacy of Lando dermal scaffold for promoting repair of acute full-thickness skin defects in pigs and explore the possible mechanism.

    Methods: Three 5 cm×5 cm full-thickness skin defects were created on the left dorsal skin (control group) and another 3 on the right dorsal skin (treatment group) of each of 6 Tibetan pigs. The wounds in the treatment group were covered with a bilayer artificial skin (Lando) and the control wounds with vaseline gauze. Read More

    Terminal ileum resection as a trigger for Strongyloides stercoralis hyperinfection and ensuing serial sepsis in a 37-year-old patient with complicated Crohn's disease: a case report.
    Z Gastroenterol 2018 04 11;56(4):380-383. Epub 2018 Apr 11.
    University Hospital Center Zagreb, Division of Gastroenterology and Hepatology, Zagreb, Croatia.
    The nematode Strongyloides stercoralis, outside the tropics and subtropics present in small endemic foci, can cause an infection after direct skin contact with contaminated soil containing infective filariform larvae and, rarely, after intimate interhuman contact or after transplantation of an infected solid organ. Following skin penetration, migration, and maturation through several stages, a small number of invasive filariform larvae can develop anew in the gut lumen, perpetuating new cycles of penetration, tissue migration, and reproduction, without leaving the host.In a state of immunosuppression, autoinfection can progress to life-threatening hyperinfection and/or infection disseminated through virtually any organ. Read More

    A successful treatment of necrotizing fasciitis following the surgery of distal radius plate removal: A case report and literature review.
    Medicine (Baltimore) 2018 Apr;97(15):e0305
    Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    Rationale: Necrotizing fasciitis (NF) is defined as a rare, rapidly progressive, and highly lethal skin infection characterized by necrosis of the fascia and subcutaneous tissue.

    Patient Concerns: The present study aims to discuss the case of a 35-year-old man who developed NF following a routine sterile right distal radius bone plate removal surgery.

    Diagnoses: The patient was suspected of NF based on his clinical manifestations, laboratory tests, and imaging results. Read More

    Preserving Basement Membranes during Detachment of Cultivated Oral Mucosal Epithelial Cell Sheets for the Treatment of Total Bilateral Limbal Stem Cell Deficiency.
    Cell Transplant 2018 Feb;27(2):264-274
    1 Banque de Tissus et de Cellules des Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France.
    Total bilateral limbal stem cell deficiency leading to loss of corneal clarity, potential vision loss, pain, photophobia, and keratoplasty failure cannot be treated by autologous limbal transplantation, and allogeneic limbal transplantation requires subsequent immunosuppressive treatment. Cultured autologous oral mucosal epithelial cells have been shown to be safe and effective alternatives. These cells can be transplanted on supports or without support after detachment from the culture dishes. Read More

    Minimally invasive direct coronary bypass surgery via distal mini-sternotomy : Promising clinical results with anaortic, multivessel, all-arterial technique.
    Herz 2018 Apr 10. Epub 2018 Apr 10.
    Mid-German Heart Center, Department of Internal Medicine III (KIM-III), Division of Cardiology, Angiology and Intensive Medical Care, University Hospital Halle, Martin-Luther-University Halle, Ernst-Grube-Straße 40, 06120, Halle (Saale), Germany.
    Background: Minimally invasive direct coronary artery bypass grafting (MIDCAB) was developed to decrease perioperative morbidity, some of which may be related to the use of cardiopulmonary bypass and to cross-clamping of the aorta. We report our initial experience with multivessel MIDCAB via distal mini-sternotomy (DIMS). DIMS is performed to gain access to the left and right internal thoracic arteries and to reach the left anterior descending coronary artery (LAD), diagonal branches, and right coronary artery (RCA). Read More

    Liposuction Treatment of Lymphedema.
    Semin Plast Surg 2018 Feb 9;32(1):42-47. Epub 2018 Apr 9.
    Department of Clinical Sciences, Lund University, Plastic and Reconstructive Surgery, Skåne University Hospital, Malmö, Sweden.
    In the Western world, lymphedema most commonly occurs following treatment of cancer. Limb reductions have been reported utilizing various conservative therapies including manual lymph and pressure therapy, as well as by microsurgical reconstruction involving lymphovenous shunts and transplantation of lymph vessels or nodes. Failure of these conservative and surgical treatments to provide complete reduction in patients with long-standing pronounced lymphedema is due to the persistence of excess newly formed subcutaneous adipose tissue in response to slow or absent lymph flow, which is not removed in patients with chronic non-pitting lymphedema. Read More

    Minimization of the perianal infection rate of hematological malignancies with agranulocytosis by quality control circle activity and patient-hospital-student win-win concept.
    J Int Med Res 2018 Jan 1:300060517726863. Epub 2018 Jan 1.
    1 198153 Southern Medical University Nanfang Hospital , Guangzhou, Guangdong, China.
    Objective The agranulocytosis-associated perianal infection (PI) rate ranges from 60% to 100% among patients with hematopoietic malignancies. In this study, we assessed the efficacy of a quality control circle (QCC) to minimize the PI rate. Methods Among 274 patients with severe immunodeficiency (agranulocytosis of ≥2 weeks) in our bone marrow transplantation center, the PI rate was 17. Read More

    Subcutaneous administration of a Neutralizing IL-1β antibody prolongs limb allograft survival.
    Am J Transplant 2018 Apr 6. Epub 2018 Apr 6.
    Daniel Swarovski Research Laboratory (DSL), Department of Visceral, Transplant and Thoracic Surgery, Center of Operative Medicine, Medical University of Innsbruck, Innsbruck, Austria.
    Cytokine expression profiles revealed IL-1ß highly upregulated in rejecting skin of limb allografts. We investigate the effect of intragraft treatment with a neutralizing IL-1β-antibody in limb-transplantation. Following allogenic hind-limb transplantation, Lewis rats were either left untreated (1) or treated with anti-lymphocyte-serum + tacrolimus (baseline) (2); baseline immunosuppression + anti-IL-1β (1mg/kg once/week, 6-8 subcutaneous injections) into the transplanted (3) or contralateral (4) limb. Read More

    Nephrologists' perspectives on cancer screening in patients with chronic kidney disease: an interview study.
    Nephrology (Carlton) 2018 Apr 6. Epub 2018 Apr 6.
    Sydney School of Public Health, University of Sydney, Sydney, NSW, 2006.
    Aim: Patients with chronic kidney disease (CKD) have an increased risk of cancer compared with the general population. Despite this, there is considerable variability in cancer screening practices among nephrologists which may reflect uncertainties about the benefits and harms of screening, the additional costs, and competing priorities among the complex issues that patients are confronted with. We aimed to describe nephrologists' perspectives and approaches to cancer screening in CKD. Read More

    Superficial Surgical Site Infection in Hepatobiliary-Pancreatic Surgery: Subcuticular Suture Versus Skin Staples.
    J Gastrointest Surg 2018 Apr 9. Epub 2018 Apr 9.
    Department of Digestive and Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, 1163 Tatemachi, Hachioji-shi, Tokyo, 193-0998, Japan.
    Purpose: Postoperative superficial surgical site infection is a major complication in hepatobiliary-pancreatic surgery. We aimed to compare the efficacy of subcuticular sutures versus staples for skin closure in preventing superficial surgical site infection in hepatobiliary-pancreatic surgery.

    Methods: Consecutive patients who underwent hepatobiliary-pancreatic surgery at our hospital from October 2006 to March 2011 and from April 2012 to March 2015 were reviewed retrospectively. Read More

    Aesthetic Refinements after Radial Free Flap Phalloplasty: Optimizing the Donor Site and the Phallus.
    Plast Reconstr Surg Glob Open 2017 Dec 28;5(12):e1611. Epub 2017 Dec 28.
    Department of Plastic and Reconstructive Surgery, Institute of Plastic Surgery Dr. Ivan Mañero, Barcelona, Spain; and the Department of Gynecology, Institute of Plastic Surgery Dr. Ivan Mañero, Barcelona, Spain.
    Background: Phalloplasty with radial forearm flap is the gold standard for female-to-male sex reassignment surgery. However, it leaves a stigmatizing forearm scar, and as the new phallus is created with the forearm's skin and fat, it does not look like that of a biological man. The aesthetic appearance of the donor site and the neophallus can be optimized after phalloplasty. Read More

    Split Tolerance in a Murine Model of Heterotopic En Bloc Chest Wall Transplantation.
    Plast Reconstr Surg Glob Open 2017 Dec 28;5(12):e1595. Epub 2017 Dec 28.
    Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.; Ruprecht-Karls University Heidelberg Medical Faculty, Heidelberg, Germany; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Md.; and Radiology and Radiological Science-Magnetic Resonance Research, Institute for Cell Engineering, Kennedy Krieger Institute's F.M. Kirby Research Center, Baltimore, Md.
    Background: Congenital and acquired chest wall deformities represent a significant challenge to functional reconstruction and may impact feasibility of heart transplantation for patients with end-stage organ failure. In the recent past, the concept of replacing like-with-like tissue by using vascularized composite allografts (VCA) has been enthusiastically employed for reconstruction of complex tissue defects.

    Methods: In this study, we introduce a novel murine model for en bloc chest wall, heart, and thymus transplantation and thereby the use of complex tissue allografts for reconstruction of both chest wall defects and also end-stage organ failure. Read More

    Efficacy of Homologous, Platelet-rich Plasma Dressing in Chronic Non-healing Ulcers: An Observational Study.
    Cureus 2018 Feb 2;10(2):e2145. Epub 2018 Feb 2.
    Obstetric and Gynaecology, Mahatma Gandhi Medical College and Research Institute, Pondicherry, India.
    Background Chronic non-healing ulcers are a frequent problem in developing countries and represent a heavy burden to the patients because they lack the necessary growth factors (GFs) to maintain the healing process and are frequently complicated by super, added infections. Traditional therapies, such as regular dressings and wound debridement, cannot provide satisfactory results since these treatments are not able to provide the necessary GFs. Platelet-rich plasma (PRP) helps in enhancing the wound healing by releasing various GFs. Read More

    Cancer risks in recipients of renal transplants: a meta-analysis of cohort studies.
    Oncotarget 2018 Mar 16;9(20):15375-15385. Epub 2017 Dec 16.
    Department of Urological Transplantation, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
    Renal transplantation is associated with an increased risk of cancers at multiple sites; however, the relationships between increased cancer risk and participant characteristics remain unclear. We searched PubMed, Embase, and the Cochrane Library to identify prospective observational studies performed up to July 2017. Totally 11 prospective studies reported data on 79,988 renal transplant recipients were included. Read More

    Efficacy and long-term longitudinal follow-up of bone marrow mesenchymal cell transplantation therapy in a diabetic patient with recurrent lower limb bullosis diabeticorum.
    Stem Cell Res Ther 2018 Apr 10;9(1):99. Epub 2018 Apr 10.
    Department of Endocrinology and Nephrology, Diabetic Foot Center, Affliated Central Hospital of Chongqing University, Chongqing Emergency Medical Hospital, Chongqing, China.
    Bullosis diabeticorum is a rare presentation of cutaneous manifestation most commonly affecting the lower limbs in patients with diabetes. The appearance, often as insidious as its resolution, is characterized by tense blisters on the skin surfaces of the lower limbs and the feet. The cause still remains unclear, but it may relate to microangiopathy and neuropathy. Read More

    Fat Grafting Volume Restoration to the Brow and Temporal Regions.
    Facial Plast Surg 2018 Apr 9;34(2):164-172. Epub 2018 Apr 9.
    Facial Plastic Surgery, Delray Beach, Florida.
    Primary manifestations of facial aging are the reduction in subcutaneous tissue volume, especially the atrophy of fat as well as bone volume depletion which directly contribute to loss of support and laxity of the skin. Depressions and hollows develop with a visible disruption of the cosmetic facial aesthetic units resulting in harsh shadows. This is especially evident in the eyebrow and temporal regions which accentuate the appearance of brow ptosis and a hollow, almost cadaveric look to the temple. Read More

    Contemporary Management of Adult Acquired Buried Penis.
    BJU Int 2018 Apr 6. Epub 2018 Apr 6.
    King's College London, MRC Centre for Transplantation, London.
    In 2014, The World Health Organization reported that 1.9 billion adults, 39% of the population, were overweight or obese [1]. Unlike most complications of obesity, adult acquired buried penis is an uncomfortable topic which may be overlooked. Read More

    Behaviors of active sunbeds users and their knowledge on the potential health risks; results of cross-sectional study in Poland.
    J Cosmet Dermatol 2018 Apr 6. Epub 2018 Apr 6.
    Department of Epidemiology, School of Medicine in Katowice Medical University of Silesia, Katowice, Poland.
    Background: Current literature review indicates that there is an increase in risk of skin melanoma due to the use of sunbeds.

    Aims: To assess behaviors and opinions about health risk related to tanning.

    Methods: From March 2012 to June of the same year, nonrepresentative cross-sectional study was conducted online concerning knowledge and behaviors during tanning. Read More

    The Impact of Recipient Site External Expansion in Fat Grafting Surgical Outcomes.
    Plast Reconstr Surg Glob Open 2018 Feb 8;6(2):e1649. Epub 2018 Feb 8.
    Department of Plastic, Reconstructive, Aesthetic, and Hand Surgery, Basel University Hospital, Basel, Switzerland; Department of Biomedicine, University of Basel, Basel, Switzerland; and Department of Biomedical Engineering, University of Basel, Basel, Switzerland.
    Background: The fat grafting process includes the 4 phases of tissue harvesting, processing, recipient-site preparation, and reinjection. Among them, the preparation of the recipient site has never been exhaustively reviewed. We aim to provide a comprehensive overview of the methods to prepare the recipient site through external expansion with the resulting outcomes. Read More

    Reconstruction of Anterior Neck Scar Contracture Using A Perforator-Supercharged Transposition Flap.
    Plast Reconstr Surg Glob Open 2018 Feb 8;6(2):e1485. Epub 2018 Feb 8.
    Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, Tokyo, Japan.
    Reconstruction of the anterior neck requires attention to both aesthetic and functional outcomes. In general, skin grafts are not suitable for anterior neck reconstruction in Asian patients, even when artificial dermis is used before skin grafting. Therefore, we have employed various types of thin flaps for anterior neck reconstruction, including the cervico-pectoral flap. Read More

    Multimodal label-free imaging of living dermal equivalents including dermal papilla cells.
    Stem Cell Res Ther 2018 Apr 3;9(1):84. Epub 2018 Apr 3.
    Institute of Biomedical Technologies, Nizhny Novgorod State Medical Academy, Minin and Pozharsky Square, 10/1, Nizhny Novgorod, 603005, Russia.
    Background: Despite the significant progress in the development of skin equivalents (SEs), the problem of noninvasively assessing the quality of the cell components and the collagen structure of living SEs both before and after transplantation remains. Undoubted preference is given to in vivo methods of noninvasive, label-free monitoring of the state of the SEs. Optical bioimaging methods, such as cross-polarization optical coherence tomography (CP OCT), multiphoton tomography (MPT), and fluorescence lifetime imaging microscopy (FLIM), present particular advantages for the visualization of such SEs. Read More

    Aerosol Gemcitabine after Amputation Inhibits Osteosarcoma Lung Metastases but Not Wound Healing.
    Sarcoma 2018 21;2018:3143096. Epub 2018 Jan 21.
    The University of Texas MD Anderson Cancer Center, Division of Pediatrics, 1515 Holcombe Blvd., Unit 0853, Houston, TX 77030, USA.
    Background: In newly diagnosed osteosarcoma (OS) patients, the time between surgery and resumption of chemotherapy is 2-7 weeks. Delays > 16 days are associated with increased risk of relapse and decreased overall survival. Identifying an effective therapy that can be used postoperatively may prevent relapse. Read More

    The treatment of post-traumatic facial skin defect with artificial dermis.
    Arch Craniofac Surg 2018 Mar 20;19(1):35-40. Epub 2018 Mar 20.
    Department of Plastic and Reconstructive Surgery, Dong Kang General Hospital, Ulsan, Korea.
    Background: When a skin defect occurs, clinicians must work to restore the original skin quality as soon as possible. Accordingly, an artificial dermis can be used to supplement the wound and prevent severe scar contracture formation. The Terudermis is an artificial dermis that is simple and easy to use. Read More

    Percutaneous Autologous Fat Injection Following 2-Layer Flap Lower Blepharoplasty for the Correction of Tear Trough Deformity.
    J Craniofac Surg 2018 Mar 30. Epub 2018 Mar 30.
    Department of Plastic Surgery, Konkuk University School of Medicine.
    Tear trough deformity has been an area that has received much attention in terms of esthetic improvements. Fat transposition has been commonly used for the treatment of tear trough deformity. As some patients have had minimal improvement by that method, we propose the use of fat grafting combined with open blepharoplasty to complement the sunken area, including some of anterior maxilla region, and evaluate and precisely remove the excessive tissue. Read More

    Evaluation of postoperative changes in vascularized iliac bone grafts used for mandibular reconstruction.
    Int J Oral Maxillofac Surg 2018 Mar 29. Epub 2018 Mar 29.
    Department of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University, Tochigi, Japan.
    Vascularized iliac bone grafts are used for mandibular reconstruction, but the factors affecting graft maintenance are unknown. This study explored the postsurgical changes in vascularized iliac bone grafts in patients who had undergone mandibular reconstruction after segmental resection. The study involved 24 patients (16 men and eight women) with oral tumours or osteoradionecrosis. Read More

    Delayed versus standard assessment for excision surgery in patients with Buruli ulcer in Benin: a randomised controlled trial.
    Lancet Infect Dis 2018 Mar 28. Epub 2018 Mar 28.
    University of Groningen, Department of Internal Medicine/Infectious Diseases, University Medical Centre Groningen, Groningen, Netherlands. Electronic address:
    Background: Surgical intervention was once the mainstay of treatment for Buruli ulcer disease, a neglected tropical disease caused by Mycobacterium ulcerans. Since the introduction of streptomycin and rifampicin for 8 weeks as standard care, surgery has persisted as an adjunct therapy, but its role is uncertain. We investigated the effect of delaying the decision to operate to 14 weeks on rates of healing without surgery. Read More

    Management of complex pediatric laryngotracheal stenosis with skin graft reconstruction.
    Int J Pediatr Otorhinolaryngol 2018 May 15;108:46-48. Epub 2018 Feb 15.
    Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye & Ear Infirmary, Boston, MA, USA. Electronic address:
    Objectives: For pediatric patients with laryngotracheal stenosis, the ultimate goal is creation of a safe, functional airway. Unfortunately, wound healing in a hollow structure can complicate repair attempts, leading to restenosis. Herein, we present our experience using skin-grafting techniques in two complex pediatric laryngotracheal stenosis cases, leading to successful decannulation or speech production. Read More

    Genetic overexpression of COMP-Ang1 impairs BM microenvironment and induces senescence of BM HSCs.
    Biochem Biophys Res Commun 2018 May 31;499(3):669-674. Epub 2018 Mar 31.
    Department of Bioactive Material Sciences, Research Center of Bioactive Materials, Chonbuk National University, Jeonju, 54896, South Korea; Cluster for Craniofacial Development and Regeneration Research, Institute of Oral Biosciences and School of Dentistry, Chonbuk National University, Jeonju, 54896, South Korea. Electronic address:
    Supplemental Angiopoietin 1 (Ang1) exerts its therapeutic potential on microvascular regression-associated diseases, and this potential is linked with the function of hematopoietic stem cells (HSCs). However, the underlying mechanisms of the effect of enhanced angiogenesis on the modulation of HSCs are not yet defined. Here, we generated transgenic mice expressing Cartilage Oligomeric Matrix Protein (COMP)-Ang1 in keratin 14-expressing cells. Read More

    Computer tomographic analysis of organ motion caused by respiration and intraoperative pneumoperitoneum in a porcine model for navigated minimally invasive esophagectomy.
    Surg Endosc 2018 Mar 30. Epub 2018 Mar 30.
    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany.
    Background: Navigation systems have the potential to facilitate intraoperative orientation and recognition of anatomical structures. Intraoperative accuracy of navigation in thoracoabdominal surgery depends on soft tissue deformation. We evaluated esophageal motion caused by respiration and pneumoperitoneum in a porcine model for minimally invasive esophagectomy. Read More

    A review of campfire burns in children: The QLD experience.
    Burns 2018 Mar 27. Epub 2018 Mar 27.
    Centre for Children's Burns and Trauma Research, Centre for Children's Health Research, University of Queensland, Australia; Bond Institute of Health & Sport, Bond University, Australia.
    Introduction: Campfire burns in children are a significant health issue. It is imperative that the extent of the problem is examined and strategies discussed to inform future prevention campaigns.

    Method: A retrospective review of data from the Queensland Paediatric Burns Registry for all children presenting with campfire burns between January 2013 and December 2014 (inclusive). Read More

    Comparison of chlorhexidine-isopropanol with isopropanol skin antisepsis for prevention of surgical-site infection after abdominal surgery.
    Br J Surg 2018 Mar 30. Epub 2018 Mar 30.
    Department of General, Visceral and Transplantation Surgery and Study Centre of the German Surgical Society, University Hospital Heidelberg, Heidelberg, Germany.
    Background: Prevention of surgical-site infection (SSI) has received increasing attention. Clinical trials have focused on the role of skin antisepsis in preventing SSI. The benefit of combining antiseptic chlorhexidine with alcohol has not been compared with alcohol-based skin preparation alone in a prospective controlled clinical trial. Read More

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