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    Technical tips to enhance micrografting results in burn surgery.
    Burns 2017 Apr 22. Epub 2017 Apr 22.
    Department of Plastic, Reconstructive and Aesthetic Surgery, Singapore General Hospital, Outram Road, 169608, Singapore.
    The lack of autograft donor site is one of the greatest limiting factors for the treatment of extensive burn. Micrografting is an important revolution in burn surgery where autografts are cut into small pieces for wide and rapid coverage of burn wound. Our early experiences with the current standard micrografting technique were fraught with poor graft take as well being time and labor intensive. Read More

    Skin allograft procurement and transplantation in Mashhad, Iran: Are burn patients' needs being met?
    Cell Tissue Bank 2017 Apr 24. Epub 2017 Apr 24.
    Burns Operating Room, Department of Burns and Reconstructive Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
    Only a single donor's tissue may save or improve lives of one hundred patients. Unfortunately, low governmental and media support of tissue procurement and transplantation programs is a worldwide problem. Loss of an effective tissue procurement program in many countries like Iran, may lead to loss of many thousands valuable tissues each year. Read More

    Ten-year follow-up of a case of necrotizing fasciitis successfully treated with negative-pressure wound therapy, dermal regeneration template application, and split- thickness skin autograft.
    Acta Chir Belg 2017 Apr 25:1-5. Epub 2017 Apr 25.
    a Department of Plastic and Reconstructive Surgery , Brugmann University Hospital, Free University of Brussels , Brussels , Belgium.
    Introduction: Necrotizing fasciitis is a rapidly progressive and often fatal infection of the fasciae and subcutaneous tissues.

    Patient And Methods: In this case report, we present the treatment of a 63-year-old patient suffering from diabetes mellitus, who was admitted to the emergency unit for severe right gluteal pain, which had begun 24 hours before admission. Cutaneous symptoms, oliguria, metabolic acidosis, acute renal failure, severe hypotension, and tachycardia occurred, and the patient was admitted to Intensive Care a few hours after initial admission. Read More

    Hair diameter evaluation in different regions of the safe donor area in Asian populations.
    Int J Dermatol 2017 Apr 24. Epub 2017 Apr 24.
    Innovative Skin and Laser Surgery Center, Bangkok, Thailand.
    Background: There is little information about how hair diameter differences within the safe donor area. Thicker or thinner hair may be needed depending on the recipient area, hairline design, and surgical purpose.

    Methods: Thirty-eight non-alopecic subjects (19 males and 19 females) were evaluated. Read More

    Human Effector Memory T Helper Cells Engage with Mouse Macrophages and Cause Graft-versus-Host-Like Pathology in Skin of Humanized Mice Used in a Nonclinical Immunization Study.
    Am J Pathol 2017 Apr 19. Epub 2017 Apr 19.
    Regenerative Immune Therapies Applied, Hannover Medical School, Hannover, Germany; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany. Electronic address:
    Humanized mice engrafted with human hematopoietic stem cells and developing functional human T-cell adaptive responses are in critical demand to test human-specific therapeutics. We previously showed that humanized mice immunized with long-lived induced-dendritic cells loaded with the pp65 viral antigen (iDCpp65) exhibited a faster development and maturation of T cells. Herein, we evaluated these effects in a long-term (36 weeks) nonclinical model using two stem cell donors to assess efficacy and safety. Read More

    Caring for critically injured children: An analysis of 56 pediatric damage control laparotomies.
    J Trauma Acute Care Surg 2017 May;82(5):901-909
    From the Department of Surgery (M.A.V., R.L.C.), Division of Trauma (J.P.H., L.C.-W., S.E.R.), Cooper Research Institute (K.H., J.P.G.), Cooper University Hospital, Camden, New Jersey; and Division of Trauma (M.J.S.), Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
    Background: Injury is the leading cause of death in children under 18 years. Damage control principles have been extensively studied in adults but remain relatively unstudied in children. Our primary study objective was to evaluate the use of damage control laparotomy (DCL) in critically injured children. Read More

    Regeneration of full-thickness skin defects by differentiated adipose-derived stem cells into fibroblast-like cells by fibroblast-conditioned medium.
    Stem Cell Res Ther 2017 Apr 20;8(1):92. Epub 2017 Apr 20.
    Department of Plastic and Reconstructive Surgery, Institute of Human-Environment Interface Biology, Seoul National University College of Medicine, Seoul, 110-799, Republic of Korea.
    Background: Fibroblasts are ubiquitous cells in the human body and are absolutely necessary for wound healing such as for injured skin. This role of fibroblasts was the reason why we aimed to differentiate human adipose-derived stem cells (hADSCs) into fibroblasts and to test their wound healing potency. Recent reports on hADSC-derived conditioned medium have indicated stimulation of collagen synthesis as well as migration of dermal fibroblasts in wound sites with these cells. Read More

    Salve and Burdock: A Safe, Effective Amish Remedy for Treatment of Traumatic Wounds?
    Adv Skin Wound Care 2017 May;30(5):213-217
    Mitchell D. Flurry, MD, is Assistant Professor, Plastic Surgery & Aesthetics, Wichita, Kansas. Kelsie L. Herring, BA, Medical Student, graduates to MD in May 2017; Logan W. Carr, MD, is Resident Physician; Randy M. Hauck, MD, is Associate Professor of Surgery; and John D. Potochny, MD, is Associate Professor of Surgery, Pennsylvania State College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania.
    Background: Amish patients show a demonstrated preference for traditional, herbal remedies over modern medical interventions such as skin grafting. One such remedy is a mixture of Burn & Wound Ointment (B & W Ointment; Holistic Acres, LLC; Newcomerstown, Ohio) and steeped burdock leaves. Although both have demonstrated some antimicrobial and wound healing properties, burdock and/or the combination of B & W Ointment and burdock has never been studied to determine its purported ability to reduce pain, prevent infection, and accelerate wound healing. Read More

    GNAQ TT(-695/-694)GC Polymorphism Is Associated with Increased Gq Expression, Vascular Reactivity, and Myocardial Injury after Coronary Artery Bypass Surgery.
    Anesthesiology 2017 Apr 19. Epub 2017 Apr 19.
    From Klinik für Anästhesiologie und Intensivmedizin (U.H.F., S.K., T.K., J.P.), Die Blutdruck Praxis, Dorsten (A.M.), Klinik für Thorax- und kardiovaskuläre Chirurgie (H.J., M.T.), and Institut für Pharmakogenetik (W.S.), Universität Duisburg-Essen, Essen; and Universitätsklinikum Essen (U.H.F., S.K., T.K., J.P., H.J., M.T.), Essen, Germany.
    Background: Angiotensin II receptor type 1-mediated activation of the α-subunit of the heterotrimeric Gq protein evokes increased vasoconstriction and may promote hypertrophy-induced myocardial damage. The authors recently identified a TT(-695/-694)GC polymorphism in the human Gq promoter, the GC allele being associated with an increased prevalence of cardiac hypertrophy. In this article, the authors tested whether the TT(-695/-694)GC polymorphism is associated with differences in (1) myocardial Gq protein expression, (2) vascular reactivity, and (3) myocardial damage after coronary artery bypass grafting. Read More

    A Review of Ocular Graft-Versus-Host Disease.
    Optom Vis Sci 2017 May;94(5):545-555
    *OD, FAAO Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore Maryland (SZM), and Optometry, VA Boston Healthcare System, Boston, Massachusetts (JA).
    : Graft-versus-host disease (GVHD) is a major complication that occurs following allogeneic hematopoietic stem cell transplantation, which is a potential curative therapy used in a variety of malignant or benign hematological diseases. Graft-versus-host disease primarily occurs in many organs, but most notably in the skin, lungs, gastrointestinal tract, liver, eyes, mucosa, and musculoskeletal system. Ocular manifestations of GVHD may precede other systemic GVHD findings, and it may be a poor prognosis for mortality. Read More

    Efficacy and tolerance of ruxolitinib in refractory sclerodermatous chronic Graft-Versus-Host Disease.
    Br J Dermatol 2017 Apr 19. Epub 2017 Apr 19.
    Service de Dermatologie, AP-HP, Hôpital Saint-Louis, Paris, France.
    Chronic graft-versus-host disease (cGVHD) is frequent and severe after allogeneic hematopoietic stem cell transplantation (AHSCT), with unmet therapeutic needs.(1) A recent retrospective study has shown the potential efficacy of ruxolitinib, a selective Janus Kinase (JAK) 1/2 inhibitor, for the treatment of acute (n=54) and chronic GVHD (n=41) with a 81.5% and 85. Read More

    Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells.
    Oncotarget 2017 Mar 15. Epub 2017 Mar 15.
    Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
    Regulatory T cells (Tregs) are potential immunotherapeutic candidates to induce transplantation tolerance. However, stability of Tregs still remains contentious and may potentially restrict their clinical use. Recent work suggested that epigenetic imprinting of Foxp3 and other Treg-specific signature genes is crucial for stabilization of immunosuppressive properties of Foxp3+ Tregs, and that these events are initiated already during early stages of thymic Treg development. Read More

    Postoperative complications with cryotherapy in bone tumors.
    J Bone Oncol 2017 Jun 6;7:13-17. Epub 2017 Apr 6.
    Department of Orthopaedic Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, United States.
    The technique of cryosurgery has been used to control local recurrence in a variety of benign and malignant bone tumors. Early studies revealed significant complication rates (25%) that included fracture, infection, and soft tissue injury. Our method of cryosurgery has yielded excellent tumor control with improved complication rates. Read More

    Facial carbuncle - a new method of conservative surgical management plus irrigation with antibiotic-containing solution.
    J Laryngol Otol 2017 Apr 17:1-4. Epub 2017 Apr 17.
    Department of Otorhinolaryngology, Head and Neck Surgery,Sibu Hospital,Sarawak,Malaysia.
    Objective: This paper reports on a non-conventional method for the management of facial carbuncles, highlighting its superiority over conventional surgical treatment in terms of cosmetic outcome and shorter duration of wound healing.

    Background: The mainstay of treatment for carbuncles involves the early administration of antibiotics in combination with surgical intervention. The conventional saucerisation, or incision and drainage, under normal circumstances results in moderate to large wounds, which may need secondary surgery such as skin grafting, resulting in a longer duration of wound healing and jeopardising cosmetic outcome. Read More

    The diagnosis and management of NK/T-cell lymphomas.
    J Hematol Oncol 2017 Apr 14;10(1):85. Epub 2017 Apr 14.
    Department of Medicine, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, China.
    Extranodal natural killer (NK)/T-cell lymphoma is an aggressive malignancy of putative NK-cell origin, with a minority deriving from the T-cell lineage. Pathologically, the malignancy occurs in two forms, extranodal NK/T-cell lymphoma, nasal type; and aggressive NK-cell leukaemia. Lymphoma occur most commonly (80%) in the nose and upper aerodigestive tract, less commonly (20%) in non-nasal areas (skin, gastrointestinal tract, testis, salivary gland), and rarely as disseminated disease with a leukemic phase. Read More

    Cost-effectiveness of silver dressings for paediatric partial thickness burns: An economic evaluation from a randomized controlled trial.
    Burns 2017 Apr 10. Epub 2017 Apr 10.
    Centre for Children's Burns and Trauma Research, Child Health Research Centre, The University of Queensland, Australia; Tissue Repair and Regeneration Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Australia; Pegg Leditschke Children's Burns Centre, Lady Cilento Children's Hospital, Brisbane, Australia; Institute of Health and Biomedical Innovation and School of Public Health & Social Work, Queensland University of Technology, Australia; Centre for Functioning and Health Research, Metro South Health, Australia.
    Background: Partial thickness burns of up to 10% total body surface area (TBSA) in children are common injuries primarily treated in the outpatient setting using expensive silver-containing dressings. However, economic evaluations in the paediatric burns population are lacking to assist healthcare providers when choosing which dressing to use. The aim of this study was to conduct a cost-effectiveness analysis of three silver dressings for partial thickness burns ≤10% TBSA in children aged 0-15 years using days to full wound re-epithelialization as the health outcome. Read More

    [Recurrent pulmonary infection and oral mucosal ulcer].
    Zhongguo Dang Dai Er Ke Za Zhi 2017 Apr;19(4):452-457
    Department of Pediatrics, Xiangya Hospital, Central South University, Changsha 410008, China.
    An 8-year-old girl who had experienced intermittent cough and fever over a 3 year period, was admitted after experiencing a recurrence for one month. One year ago the patient experienced a recurrent oral mucosal ulcer. Physical examination showed vitiligo in the skin of the upper right back. Read More

    New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management.
    Crit Care 2017 Apr 14;21(1):89. Epub 2017 Apr 14.
    General Hospital Department of Medicine I, Medical University of Vienna, Vienna, Austria.
    Pharmacological and cellular treatment of cancer is changing dramatically with benefits for patient outcome and comfort, but also with new toxicity profiles. The majority of adverse events can be classified as mild or moderate, but severe and life-threatening complications requiring ICU admission also occur. This review will focus on pathophysiology, symptoms, and management of these events based on the available literature. Read More

    Retrospective evaluation of factors influencing successful skin grafting for patients with skin cancer of the foot.
    J Dermatol 2017 Apr 13. Epub 2017 Apr 13.
    Department of Dermatology, Shizuoka Cancer Center, Shizuoka, Japan.
    Skin grafting is a simple method for reconstruction of a large defect on the foot. Although skin grafting on the foot sometimes fails, it is not clear what factors influence the success rate of skin grafting. We analyzed data for 71 patients with skin cancer of the foot who underwent reconstruction of defects with skin grafting. Read More

    Combining therapeutic antibodies using basiliximab and etanercept for severe steroid-refractory acute graft-versus-host disease: A multi-center prospective study.
    Oncoimmunology 2017 6;6(3):e1277307. Epub 2017 Jan 6.
    Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou, Zhejiang Province, P.R. China.
    Acute graft versus host disease (aGVHD) remains a major problem after allogeneic hematopoietic stem cell transplantation. Standard frontline therapy for aGVHD involves corticosteroids. However, fewer than half of patients have a lasting complete response. Read More

    Effector Antitumor and Regulatory T Cell Responses Influence the Development of Nonmelanoma Skin Cancer in Kidney Transplant Patients.
    Transplantation 2017 Apr 11. Epub 2017 Apr 11.
    1Kidney transplant Unit, Nephrology department. Bellvitge University Hospital. IDIBELL. Barcelona, Spain. 2Experimental Nephrology Laboratory. IDIBELL. Barcelona. Spain. 3Renal transplant Unit, Nephrology department. Germans Trias i Pujol University Hospital. Barcelona, Spain. 4Pathology department, Bellvitge University Hospital. IDIBELL. Barcelona, Spain. 5Pathology department, Germans Trias i Pujol University Hospital. Barcelona, Spain.
    Background: Chronic immunosuppression promotes Nonmelanocytic Squamous Cell Carcinoma (SCC) after kidney transplantation. Adaptive and innate immunity play a key role controlling tumor growth and are influenced by different immunosuppressive agents. We hypothesized that functional impairment of tumor-specific T cell responses due to CNI could contribute to SCC development, whereas conversion to mTOR-i could recover this protective immune response. Read More

    Skin-nipple-sparing mastectomy: The first approach in primary myxoid chondrosarcoma of the breast.
    Int J Surg Case Rep 2017 22;34:130-133. Epub 2017 Mar 22.
    Department of General and Emergency Surgery and Organs Transplantation, "Policlinico Paolo Giaccone", University of Palermo, Italy.
    The primary mammary chondrosarcoma corresponds to less than 0,5% of the mammary malignancies. For the period ranging from 1967 to 2014, only 18 cases were reported in the literature. A 41year old woman found a hard nodule on her external right superior quadrant/axillary prolongation through breast self-examination. Read More

    Hypocellular acute myeloid leukemia treated with bone marrow transplantation.
    Pediatr Int 2017 Apr;59(4):490-493
    Department of Pediatrics, St Marianna University School of Medicine Hospital, Kawasaki, Japan.
    Hypocellular acute myeloid leukemia (AML) mainly occurs in elderly patients, and is extremely rare in childhood. There is still no established treatment for hypocellular AML. We report the case of an 11-year-old boy with hypocellular AML who was treated successfully with allogenic bone marrow transplantation (allo-BMT). Read More

    Staged Tubularized Auto-Graft (STAG) Repair for Primary Proximal Hypospadias with ≥30° Ventral Curvature.
    J Urol 2017 Apr 8. Epub 2017 Apr 8.
    PARC Urology. Electronic address:
    Purpose: We report outcomes in consecutive patients with primary proximal hypospadias and ventral curvature≥ 30° after degloving, all repaired by 2-stage tubularized autografts (STAG), a variation of the Nicolle-Bracka procedure.

    Materials And Methods: Consecutive boys with proximal hypospadias and ventral curvature (VC) ≥ 30° after degloving all underwent transection of the urethral plate. Those with persistent VC ≥ 30° additionally had 3 ventral corporotomies without corporal grafting for straightening. Read More

    The Use of Acellular Urinary Bladder Matrix as Coverage for Fasciocutaneous Free Flap Donor Sites: An Alternative to Traditional Grafting Procedures.
    J Oral Maxillofac Surg 2017 Mar 18. Epub 2017 Mar 18.
    Assistant Professor, Oral and Maxillofacial Surgery, Oral, Head & Neck Oncology and Microvascular Surgery, The University of Texas Health Science Center at Houston, Houston, TX.
    Purpose: The purpose of this review is to 1) evaluate our early experience with urinary bladder matrix as a dressing for the management of complex wounds subsequent to fasciocutaneous or osteocutaneous vascularized tissue harvests, 2) assess coverage of exposed tendons and the duration of granulation and epithelial coverage, and 3) assess esthetic and functional outcomes compared with traditional means for the management of vascularized tissue harvest sites.

    Patients And Methods: This prospective study consisted of 8 consecutive patients in whom a substantial cutaneous component was harvested as part of a vascularized tissue reconstruction, which did not permit for primary closure (n = 7) or had skin graft failure (exposed tendon) that required additional treatment (n = 1).

    Results: Functional and esthetic outcomes were comparable to those of traditional methods of donor site closure as determined by clinical evaluation and subjective assessment by the patient. Read More

    Generation of chimeric minipigs by aggregating 4- to 8-cell-stage blastomeres from somatic cell nuclear transfer with the tracing of enhanced green fluorescent protein.
    Xenotransplantation 2017 Apr 11. Epub 2017 Apr 11.
    Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
    Background: Blastocyst complementation is an important technique for generating chimeric organs in organ-deficient pigs, which holds great promise for solving the problem of a shortage of organs for human transplantation procedures. Porcine chimeras have been generated using embryonic germ cells, embryonic stem cells, and induced pluripotent stem cells; however, there are no authentic pluripotent stem cells for pigs. In previous studies, blastomeres from 4- to 8-cell-stage parthenogenetic embryos were able to generate chimeric fetuses efficiently, but the resulting fetuses did not produce live-born young. Read More

    Phase I Study of Clofarabine and 2-Gy Total Body Irradiation as a Non-Myeloablative Preparative Regimen for Hematopoietic Stem Cell Transplantation (HSCT) in Pediatric Patients with Hematologic Malignancies: a Therapeutic Advances in Childhood Leukemia (TACL) Consortium Study.
    Biol Blood Marrow Transplant 2017 Apr 7. Epub 2017 Apr 7.
    The Children's Hospital at TriStar Centennial and Sarah Cannon Research Institute, Nashville, TN.
    Clofarabine is a purine nucleoside analog with immunosuppressive and anti-leukemic activity and its inclusion in reduced intensity regimens could potentially improve outcomes. We performed a prospective Phase I study of clofarabine combined with 2 Gy total body irradiation (TBI) as a non-myeloablative (NMA) preparative regimen for allogeneic stem cell transplantation in pediatric patients, who were considered at high risk of mortality from standard myeloablative regimens. The main goal of the study was to delineate the maximum feasible dose (MFD) of clofarabine in combination with 2 Gy TBI. Read More

    Chemotherapy and Transplantation: The Role of Immunosuppression in Malignancy and a Review of Antineoplastic Agents in Solid Organ Transplant Recipients.
    Am J Transplant 2017 Apr 10. Epub 2017 Apr 10.
    The University of Texas MD Anderson Cancer Center, Houston, TX.
    It is estimated that solid organ transplant recipients have a two- to fourfold greater overall risk of malignancy than the general population. Some of the most common malignancies after transplant include skin cancers and posttransplant lymphoproliferative disorder. In addition to known risk factors such as environmental exposures, genetics, and infection with oncogenic viruses, immunosuppression plays a large role in the development of cancer through the loss of the immunosurveillance process. Read More

    Safety of 2-Octyl Cyanoacrylate in Spreader Grafting.
    Facial Plast Surg 2017 Apr 7;33(2):213-216. Epub 2017 Apr 7.
    Department of Otolaryngology, Madigan Army Medical Center, Tacoma, Washington.
    Cyanoacrylate adhesives can make the placement of spreader grafts in open septorhinoplasty technically easier, but its use is off-label beneath the skin. There is a theoretical risk of toxicity from cyanoacrylate breakdown products, but this risk has not been thoroughly studied in rhinoplasty. The objective was to evaluate the effects of subcutaneous cyanoacrylate use during spreader graft placement in rhinoplasty in a retrospective review of open septorhinoplasties in which 2-octyl cyanoacrylate was used to aid placement of spreader grafts. Read More

    Angiogenesis characteristics of infantile hemangioma and feasibility observation of transplantation model of human hemangioma on mice.
    Eur Rev Med Pharmacol Sci 2017 Mar;21(6):1276-1280
    Department of Burns and Plastic Surgery, Binzhou Medical University Hospital, Binzhou, China.
    Objective: To study pathogenic features of pediatric hemangiomas, we successfully established a model in mice, by transplanting human hemangioma tissues.

    Materials And Methods: The hemangioma from the leg of a two-month-old infant was dissected and sliced into several pieces. During a careful surgical procedure, the hemangioma tissues were individually transplanted into skin incisions in anesthetized mice. Read More

    Advances in Skin Regeneration Using Tissue Engineering.
    Int J Mol Sci 2017 Apr 7;18(4). Epub 2017 Apr 7.
    Center for Nanobiotechnology Research, Alabama State University, 1627 Harris Way, Montgomery, AL 36104, USA.
    Tissue engineered skin substitutes for wound healing have evolved tremendously over the last couple of years. New advances have been made toward developing skin substitutes made up of artificial and natural materials. Engineered skin substitutes are developed from acellular materials or can be synthesized from autologous, allograft, xenogenic, or synthetic sources. Read More

    [Skin carcinogenesis in renal transplant recipients].
    Rev Med Liege 2017 Mar;72(3):146-150
    Service de Dermatopathologie, CHU de Liège, Site du Sart Tilman, Liège, Belgique.
    Organ transplants are bound to the induction and upkeep of immunosuppression. The immunomodulatory regimen modalities have changed over time with an improvement of the overage graft survival. The effects are also present on the skin and its cancerogenesis which is particularly activated for the squamous cell carcinoma. Read More

    The association of the skin microbiota with health, immunity and disease.
    Clin Pharmacol Ther 2017 Apr 5. Epub 2017 Apr 5.
    Institute of Microbiology and Biotechnology, University of Ulm, Ulm, Germany.
    The human skin is densely colonized by a highly diverse microbiota comprising all three domains of life. Long believed to represent mainly a source of infection, the human skin microbiota is nowadays well accepted as an important driver of human (skin) health and well-being. This microbiota is influenced by many host and environmental factors and interacts closely with the skin immune system. Read More

    Novel Application of Extracorporeal Photopheresis as Treatment of Graft-versus-Host Disease Following Liver Transplantation.
    ACG Case Rep J 2017 29;4:e48. Epub 2017 Mar 29.
    Division of Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas, TX.
    A 48-year-old man with hepatitis C virus (HCV) cirrhosis complicated by hepatocellular carcinoma underwent liver transplantation. His course was complicated by fever, diarrhea, abdominal pain, and pancytopenia. He developed a diffuse erythematous rash, which progressed to erythroderma. Read More

    [Research progress of skin-derived precursor cells].
    Nan Fang Yi Ke Da Xue Xue Bao 2017 Mar;37(3):420-422
    Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.E-mail:
    As a novel population of neural crest-origin precursor cells, skin-derived precursor cells (SKPs) can be isolated from both embryonic and adult dermis. These cells have important values for research and potential clinical application in wound healing, organ regeneration and disease treatment for advantages in the abundance of cell sources, accessibility, potential of multipotent differentiation, and absence of ethical concerns. Here we review the developmental and anatomical origins of SKPs and their potential application in regenerative medicine. Read More

    The Association of Histologic Grade with Acute Graft-versus-Host Disease Response and Outcomes.
    Am J Hematol 2017 Apr 4. Epub 2017 Apr 4.
    Blood and Marrow Transplant Program, Cleveland Clinic, Cleveland, OH.
    Consensus criteria are routinely used to clinically grade acute graft-versus-host disease (GVHD). A histologic grading system for acute GVHD is available, but there are limited data on its correlation with clinical grade and hematopoietic cell transplantation (HCT) outcomes. Among 503 patients who underwent allogeneic HCT from 2005-2013, we identified 300 biopsy episodes of the skin and gastrointestinal (GI) tract in 231 patients. Read More

    Therapeutic effects of hydrogen on chronic graft-versus-host disease.
    J Cell Mol Med 2017 Apr 4. Epub 2017 Apr 4.
    Department of Hematology, Navy General Hospital, Beijing, China.
    The incidence of chronic graft-versus-host disease (cGVHD) is rising recent years, which has been the leading cause of non-transplantation mortality post allogenetic hematopoietic stem cell transplantation (HSCT). Imbalance of inflammatory cytokines and fibrosis plays critical roles in the pathogenesis of cGVHD. Recent studies showed that molecular hydrogen has anti-inflammatory, antioxidant, anti-fibrosis effects. Read More

    Single-Stage Separation of 3- and 4-Finger Incomplete Simple Syndactyly With Contiguous Gull Wing Flaps: A Technique to Minimize or Avoid Skin Grafting.
    J Hand Surg Am 2017 Apr;42(4):257-264
    Division of Plastic and Reconstructive Surgery, University of Florida College of Medicine, Gainesville, FL. Electronic address:
    Purpose: Staged separation of 3- and 4-finger syndactyly is commonly performed owing to concerns about vascular supply to the central digit and availability of flap skin. We performed single-stage separation of patients with incomplete syndactyly of multiple digits with adjacent contiguous dorsal gullwing flaps and avoided skin grafts in the majority of cases.

    Methods: Seventy-four webs of 31 patients with more than 2-finger incomplete syndactyly were included. Read More

    Incidence and predictors of cancer following kidney transplantation in childhood.
    Am J Transplant 2017 Mar 29. Epub 2017 Mar 29.
    Sydney School of Public Health, University of Sydney, Camperdown, NSW, Australia.
    Cancer risk is increased substantially in adult kidney transplant recipients, but the long-term risk of cancer in childhood recipients is unclear. Using the Australian and New Zealand Dialysis and Transplant Registry, the overall and site-specific incidences of cancer after transplantation in childhood recipients were compared with population-based data using standardized incidence ratios (SIR). Among 1734 childhood recipients (median age 14 years, 57% male, 85% white), 289 (16. Read More

    Sustainable effectiveness of single-treatment autologous fat grafting in adherent scars.
    Wound Repair Regen 2017 Apr 1. Epub 2017 Apr 1.
    Burn Center, Red Cross Hospital, Beverwijk.
    Following severe injury, not just the skin but also the subcutis may be destroyed. Consequently, the developing scar can become adherent to underlying structures. Reconstruction of the subcutis can be achieved by autologous fat grafting. Read More

    Emerging Biofabrication Strategies for Engineering Complex Tissue Constructs.
    Adv Mater 2017 Apr 3. Epub 2017 Apr 3.
    Laboratory for Innovations in Microengineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC, V8P 5C2, Canada.
    The demand for organ transplantation and repair, coupled with a shortage of available donors, poses an urgent clinical need for the development of innovative treatment strategies for long-term repair and regeneration of injured or diseased tissues and organs. Bioengineering organs, by growing patient-derived cells in biomaterial scaffolds in the presence of pertinent physicochemical signals, provides a promising solution to meet this demand. However, recapitulating the structural and cytoarchitectural complexities of native tissues in vitro remains a significant challenge to be addressed. Read More

    Cutaneous Burn Injury Promotes Shifts in the Bacterial Microbiome in Autologous Donor Skin: Implications for Skin Grafting Outcomes.
    Shock 2017 Mar 31. Epub 2017 Mar 31.
    *Burn & Shock Trauma Research Institute, Loyola University Chicago, Health Sciences Campus, Maywood, IL, USA †Department of Surgery, Loyola University Chicago, Health Sciences Campus, Maywood, IL, USA ‡Department of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, Health Sciences Campus, Maywood, IL, USA §Center for Biomedical Informatics, Loyola University Chicago, Health Sciences Campus, Maywood, IL, USA ¶Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA ||Departments of Dermatology and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
    Introduction: The cutaneous microbiome maintains skin barrier function, regulates inflammation, and stimulates wound healing responses. Burn injury promotes an excessive activation of the cutaneous and systemic immune response directed against commensal and invading pathogens. Skin grafting is the primary method of reconstructing full-thickness burns, and wound infection continues to be a significant complication. Read More

    Risk of melanocytic nevi and nonmelanoma skin cancer in children after allogeneic hematopoietic stem cell transplantation.
    Bone Marrow Transplant 2017 Apr 3. Epub 2017 Apr 3.
    Department of Medicine, Dermatology Program, Boston Children's Hospital, Boston, MA, USA.
    There is a known increased risk of skin cancer in the adult population after hematopoietic stem cell transplantation (HSCT). However, late dermatologic effects that children may experience after HSCT have not been well described. The primary objective of this study was to characterize nevi and skin cancers affecting children after allogeneic HSCT. Read More

    Development of Allograft Cancer after Lung Transplantation: A Case Report.
    Ann Thorac Cardiovasc Surg 2017 Mar 29. Epub 2017 Mar 29.
    Division of Pulmonology, University Hospital Zurich, Zurich, Switzerland.
    Introduction: In contrast to skin cancer and lymphoproliferative disorders, de-novo lung allograft cancer is seldom reported after lung transplantation.

    Case Report: A 19-year-old patient with severe pulmonary hypertension listed urgently for lung transplantation underwent successful bilateral lung transplant procedure receiving lungs from a 55-year-old donor with a smoking history of 30 pack years. After 3. Read More

    Operative Wound Complications Following Total Ankle Arthroplasty.
    Foot Ankle Int 2017 Apr 1;38(4):360-366. Epub 2016 Dec 1.
    4 Department of Orthopaedic Surgery, Duke University Medical Center, Durham, NC, USA.
    Background: Wound complications following total ankle replacement (TAR) potentially lead to devastating consequences. The aim of this study was to compare the operative and demographic differences in patients with and without major wound problems which required operative management. We hypothesized that increased tourniquet and operative time would negatively influence wound healing. Read More

    Salvage therapy with lenalidomide containing regimen for relapsed/refractory Castleman disease: a report of three cases.
    Front Med 2017 Apr 3. Epub 2017 Apr 3.
    Department of Hematology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, China.
    Castleman disease (CD) is uncommon non-clonal lymphoproliferative disorder with unknown etiology. No standard therapy is recommended for relapsed/refractory CD patients, thus requiring development of novel experimental approaches. Our cohort of three adult patients with multicentric CD (MCD) were treated with refractory to traditional chemotherapy lenalidomide-containing regimens (10-25 mg lenalidomide perorally administered on days 1-21 in 28-day cycle) as second- to fourth-line treatment. Read More

    A 3-Year-Old Girl with Recurrent Infections and Autoimmunity due to a STAT1 Gain-of-Function Mutation: The Expanding Clinical Presentation of Primary Immunodeficiencies.
    Front Pediatr 2017 17;5:55. Epub 2017 Mar 17.
    Allergy and Immunology Division, Hospital Nacional Edgardo Rebagliati Martins , Lima , Peru.
    We report a 3-year-old Peruvian girl, born to non-consanguineous parents. At the age of 8 months, she had a severe pneumonia complicated with empyema that required thoracic drainage and mechanical ventilation. Although no microorganisms were isolated, the patient recovered with broad-spectrum antibiotics. Read More

    European Organisation for Research and Treatment of Cancer consensus recommendations for the treatment of mycosis fungoides/Sézary syndrome - Update 2017.
    Eur J Cancer 2017 Mar 30;77:57-74. Epub 2017 Mar 30.
    Department of Dermatology, Medical University of Vienna, Vienna, Austria.
    In order to provide a common standard for the treatment of mycosis fungoides (MF) and Sézary syndrome (SS), the European Organisation for Research and Treatment of Cancer-Cutaneous Lymphoma Task Force (EORTC-CLTF) published in 2006 its consensus recommendations for the stage-adapted selection of management options for these neoplasms. Since then, the understanding of the pathophysiology and epidemiology of MF/SS has advanced, the staging system has been revised, new outcome data have been published and novel treatment options have been introduced. The purpose of the present document is to update the original recommendations bearing in mind that there are still only a limited number of controlled studies to support treatment decisions for MF/SS and that often treatment is determined by institutional experience and availability. Read More

    Reconstruction of the Adult and Pediatric Burned Hand.
    Hand Clin 2017 May;33(2):333-345
    Plastic and Reconstructive Surgery, Shriner's Hospital for Children, 51 Blossom Street, Boston, MA 02114, USA; MGH Hand Surgery Fellowship, Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA. Electronic address:
    Thermal injuries of the hand can have a great impact on function. Initial treatment should focus on the prevention of contracture through the use of tissue-sparing techniques and optimized occupational therapy. Surgical intervention should follow the standard reconstructive ladder and can involve several techniques from simple to complex including minimally invasive techniques, such as laser and steroid injection, contracture release and skin grafting, and local tissue rearrangement and regional flaps as well as distant pedicled and free flaps. Read More

    Acute Management of Hand Burns.
    Hand Clin 2017 May 1;33(2):229-236. Epub 2017 Mar 1.
    Division of Plastic and Reconstructive Surgery, Northwestern University Feinberg School of Medicine, 675 North Saint Clair Street, Suite 19-250, Chicago, IL 60611, USA. Electronic address:
    The hand is extremely susceptible to burn injuries, and hand burns can occur in up to 90% of all major burns. A thorough neurovascular examination of the hand should be performed in the acute setting. Escharotomies are required in patients with full-thickness or circumferential burns, when perfusion of the upper extremity is compromised. Read More

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