Clin Sci (Lond) 2017 Jul 22;131(13):1429-1436. Epub 2017 Jun 22.
Service de Biochimie, Centre de Biologie Humaine (CBH), CHU Amiens Sud, Amiens, France
Cancer is one of the major causes of mortality in organ transplant patients receiving immunosuppressive regimen based on Cyclosporin A (CsA). Organ transplantation and chronic immunosuppression are typically associated with skin cancers (both squamous cell carcinoma and melanoma) and renal cell carcinoma (RCC). Recent studies have shown that in addition to its immunosuppressive effects, accounted for by the inhibition of calcineurin and the modulation of the transcriptional programme of lymphocytes, CsA also directly stimulates the growth and aggressive behaviour of various cancer cells. Read More