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    Treatment of Genital Burn Injuries: Traditional Procedures and New Techniques.
    Adv Skin Wound Care 2018 Jul;31(7):314-321
    In the Department of Plastic Surgery, Hand Surgery, and Burn Center, University of Witten/Herdecke, Cologne-Merheim Medical Center, Cologne, Germany, Alexandra Schulz, MD, is a Senior Resident; Benedikt Ribitsch, MD, is a Resident; Paul Christian Fuchs, PhD, is Professor and Director; Alexandra Lipensky, MD, is a Resident; and Jennifer Lynn Schiefer, MD, is a Senior Resident. Acknowledgments: The NexoBrid product for enzymatic debridement has been approved for use in Germany and is currently an investigational product in a phase III controlled FDA trial in the United States. Dr Schulz has disclosed that she is a consultant for MediWound Ltd, although the current study was not funded by the product manufacturer. The authors have disclosed no other financial relationships related to this article. Submitted February 19, 2017; accepted in revised form August 3, 2017.
    Objective: Because genital burns are rare, only limited information on treatment guidelines is available in the literature. Vital tissue should be preserved to promote spontaneous healing because reconstruction does not always lead to satisfying results. The aim of this report is to present a general overview of current, prevailing treatment for genital burns and compare this to study authors' experiences. Read More

    Spanning External Fixation for the Treatment of Open Joint Injuries in Pediatric Burn Patients.
    Cureus 2018 Apr 16;10(4):e2484. Epub 2018 Apr 16.
    Department of Orthopaedic Surgery and Rehabilitation, The University of Texas Medical Branch.
    In this article, we report a case series on spanning external fixation for the treatment of open joint burn injuries in a pediatric population. We reviewed the case logs of all orthopedic surgeons from 2000 to 2010 at a burn hospital to identify pediatric patients with open joints secondary to burn injuries. Nine patients who sustained open joint injuries after a burn and treated with a spanning external fixator (SEF) were identified. Read More

    Jaundice caused by protrusion of a hepatic cyst into common bile duct that was resolved by choledochoscopic needle-knife electrotomy: a case report.
    BMC Gastroenterol 2018 Jun 19;18(1):90. Epub 2018 Jun 19.
    Cholelithiasis Center, East Hospital of Tongji University, 150 Jimo Road, Pudong, Shanghai, 200120, China.
    Backgroud: Hepatic cysts are the most frequent, innocuous, space-occupying lesions of the liver. The majority of solitary liver cysts are nonsymptomatic. When liver cysts reach a large size, there are some complications, including infection, rupture, spontaneous hemorrhage, obstructive jaundice, and neoplastic degeneration. Read More

    [Surgical treatment of external auricular cholesteatoma involving tympanum and papilloma].
    Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jun;32(12):937-940
    Department of Otolaryngology Head and Neck Surgery, Qilu Hospital of Shandong University,Qingdao,266035,China.
    To explore the operation treatments and their outcomes of external auditory canal cholesteatomas involving the tympanic cavity and mastoid process. Forty-two patients (45 ears) with external auditory canal cholesteatomas were included in this study who were operated. All lesions invaded the tympanic cavity and mastoid process. Read More

    Cicatricial ectropion surgery: a prospective study of long-term symptom control, patient satisfaction, and anatomical success.
    Clin Exp Ophthalmol 2018 Jun 19. Epub 2018 Jun 19.
    Department of Ophthalmology, Waikato Hospital, New Zealand.
    Importance: Cicatricial ectropion repair is effective and has a low complication rate.

    Background: To evaluate the effectiveness and long-term functional outcomes of surgical repair of lower-lid cicatricial ectropion.

    Design: Prospective consecutive case series. Read More

    Eculizumab for Transplant-Associated Thrombotic Microangiopathy in Adult Allogeneic Stem Cell Transplant Recipients.
    Eur J Haematol 2018 Jun 19. Epub 2018 Jun 19.
    Division of Pharmacy, The University of Texas MD Anderson Cancer Center, Houston, TX.
    Objective: To evaluate response rates and survival in adults with transplant-associated thrombotic microangiopathy (TA-TMA) after allogeneic hematopoietic stem cell transplantation (HSCT) who were treated with eculizumab (ECU).

    Methods: Patients were identified retrospectively and data collected through HSCT and pharmacy databases.

    Results: Ten patients with TA-TMA after allogeneic HSCT were treated with ECU between 2013 and 2016. Read More

    18F-FDG PET/CT for invasive fungal infection in immunocompromised patients.
    QJM 2018 Jun 18. Epub 2018 Jun 18.
    Biophysics and Nuclear Medicine, Strasbourg University Hospitals, Strasbourg, France.
    Background: Opportunistic invasive fungal infections (IFIs) comprise a heterogeneous spectrum of pathogens, whose early diagnosis remains challenging. Candida spp. and Aspergillus spp, the most frequent pathogens in immunocompromised patients, frequently affect lungs, liver, bone and skin. Read More

    New Therapies and Immunological Findings in Cutaneous T-Cell Lymphoma.
    Front Oncol 2018 4;8:198. Epub 2018 Jun 4.
    Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
    Primary cutaneous lymphomas comprise a group of lymphatic malignancies that occur primarily in the skin. They represent the second most common form of extranodal non-Hodgkin's lymphoma and are characterized by heterogeneous clinical, histological, immunological, and molecular features. The most common type is mycosis fungoides and its leukemic variant, Sézary syndrome. Read More

    Near complete response to Pembrolizumab in microsatellite-stable metastatic sebaceous carcinoma.
    J Immunother Cancer 2018 Jun 19;6(1):58. Epub 2018 Jun 19.
    Department of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, 420 Delaware Street SE, MMC480, Minneapolis, MN, 55455, USA.
    Background: Sebaceous carcinoma is an aggressive adnexal skin tumor with a predilection for the eyelids and sebaceous glands of the head and neck.

    Case Presentation: A 73 year-old man presented with confusion and was found to have widely disseminated sebaceous carcinoma with metastases to brain, lungs, liver, bowel, lymph nodes, and bone. Following initial treatment of the brain metastases with surgery he received post-operative radiosurgery. Read More

    Fat grafting to the face with adjunctive microneedling: a simple technique with high patient satisfaction
    Turk J Med Sci 2018 Jun 14;48(3):592-601. Epub 2018 Jun 14.
    Background/aim: Even though new techniques are emerging to overcome the inconsistent long-term viability of fat grafts, current methods for increasing fat graft survival are not routinely adaptable to all clinical environments. The purpose of this study was to determine the efficacy of microneedling as an adjunct to fat grafting to the face. Materials and methods: Twenty-two patients that underwent fat grafting to the face with adjunctive microneedling were evaluated in terms of improvement in facial skin quality and facial volume and their results were compared to those in 18 patients that underwent fat grafting without microneedling. Read More

    Motorized 0.8 mm micro-punch grafting for refractory vitiligo: A retrospective study of 230 cases.
    J Am Acad Dermatol 2018 Jun 15. Epub 2018 Jun 15.
    Eureka Skin & Laser Clinic, Seoul, Korea. Electronic address:
    Background: Punch grafting for vitiligo has been time-consuming and may result in cobblestone-like appearances. We devised a motorized 0.8 mm micro-punch grafting procedure to overcome these limitations. Read More

    Tie-Over Bolster Dressings vs Basting Sutures for the Closure of Full-Thickness Skin Grafts: A Review of the Literature.
    J Cutan Med Surg 2018 Jun 1:1203475418782152. Epub 2018 Jun 1.
    3 Micrographic Surgery and Dermatologic Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
    Background: Full-thickness skin grafting is a well-established technique in the reconstruction of various tissue defects and wounds. However, lack of uniformity in the procedure of closing and securing the grafts has led to a wide range of different techniques.

    Objective: This article reviews the use of tie-over bolster dressings compared to basting sutures for the fixation and postsurgical immobilization of full-thickness skin grafts (FTSGs), discusses details of each method, and proposes a practice guideline for the closure of FTSGs. Read More

    The unique and valuable soft tissue free flap in head and neck reconstruction: Lateral arm.
    Oral Oncol 2018 Jul 21;82:100-107. Epub 2018 May 21.
    The James Cancer Hospital and Solove Research Institute, Wexner Medical Center at The Ohio State University, Department of Otolaryngology-Head and Neck Surgery, Columbus, OH, United States. Electronic address:
    While the lateral arm free flap has been well described, there is a relative paucity in its use compared to other free flaps and regional flaps. The lateral arm free flap is a unique soft tissue free flap that provides several reconstructive advantages in head and neck reconstruction: excellent contour and color match to facial skin, well compartmentalized fat, donor nerves for nerve grafting, and the ability to two-team harvest and close the donor site without a skin graft. A detailed anatomic and harvest technique is described, along with indications and advantages of using lateral free flap for head and neck reconstruction. Read More

    Comprehensive approach to reestablishing form and function after radical parotidectomy.
    Am J Otolaryngol 2018 Jun 7. Epub 2018 Jun 7.
    Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA.
    Introduction: The reconstructive goals following radical parotidectomy include restoration of symmetry, reanimation of the face, and reestablishment of oral competence. We present our experience utilizing the anterolateral thigh (ALT) free flap, orthodromic temporalis tendon transfer (OTTT), and facial nerve cable grafting to reestablish form and function.

    Material And Methods: From 2010 to 2016, 17 patients underwent radical parotidectomy followed by immediate reconstruction. Read More

    Primary Closure of Wide Fasciotomy and Surgical Wounds Using Rubber Band-Assisted External Tissue Expansion: A Simple, Safe, and Cost-effective Technique.
    Ann Plast Surg 2018 Jun 13. Epub 2018 Jun 13.
    From the Department of Plastic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
    Background: Although decompressive fasciotomy is a limb-saving procedure in the setting of acute compartment syndrome, it leaves a large wound defect with tissue edema and skin retraction that can preclude primary closure. Numerous techniques have been described to address the challenge of closing fasciotomy wounds. This study reports our experience with fasciotomy closure using rubber bands (RBs) for external tissue expansion. Read More

    When Is It Appropriate to Put a Live Donor at Risk to Help Another Patient?
    AMA J Ethics 2018 Jun 1;20(1):537-545. Epub 2018 Jun 1.
    The director of the Comprehensive Burn Care Center and the co-director of the Institute of Burn Ethics at MetroHealth Medical Center in Cleveland, Ohio, and an assistant professor of surgery and bioethics at the Case Western Reserve University School of Medicine.
    This article considers the nature and scope of ethical decision making in monozygotic sibling (MZS) skin grafting. Although rare, identical twin-to-twin skin grafting has been reported with excellent survival rates in burn patients. Of 16 cases published to date, only a few address the ethical decision making process that is involved with monozygotic sibling skin grafting; this article discusses clinical indications and ethical challenges. Read More

    [Effect of human adipose-derived stem cells on pressure ulcer healing in mouse].
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2018 Jun;32(6):726-735
    Department of Burns and Plastic Surgery, the Affiliated Hospital of Zunyi Medical College, Zunyi Guizhou, 563003,
    Objective: To investigate the effect of human adipose-derived stem cells (hADSCs) on pressure ulcers in mouse.

    Methods: The subcutaneous adipose tissue from voluntary donation was harvested. Then the hADSCs were isolated and cultured by mechanical isolation combined with typeⅠcollagenase digestion. Read More

    The SILKIE (Skin graftIng Low friKtIon Environment) study: a non-randomised proof-of-concept and feasibility study on the impact of low-friction nursing environment on skin grafting success rates in adult and paediatric burns.
    BMJ Open 2018 Jun 14;8(6):e021886. Epub 2018 Jun 14.
    The Scar Free Foundation Centre for Children's Burn Research, Bristol Royal Hospital for Children, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.
    Objectives: To evaluate the impact of low-friction (LF) bedding on graft loss in an acute burn care setting, and to examine the feasibility and costs of using LF bedding compared with standard care.

    Design: Proof of concept before and after study with feasibility of delivering the intervention.

    Setting: Three burns services within two UK hospital trusts. Read More

    Invasive Procedures Associated With the Development of Infective Endocarditis.
    J Am Coll Cardiol 2018 Jun;71(24):2744-2752
    Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
    Background: Various invasive medical procedures might induce bacteremia and, hence, act as triggers for infective endocarditis. However, empirical data in humans on the potential dangers of invasive medical procedures in this regard are very sparse. Due to lack of sufficient data, it is currently debated whether the risk for endocarditis with medical procedures is substantial or rather negligible. Read More

    Improved keratinocyte carcinoma outcomes with annual dermatology assessment after solid organ transplantation: Population-based cohort study.
    Am J Transplant 2018 Jun 13. Epub 2018 Jun 13.
    Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada.
    Solid organ transplant recipients have a high risk of keratinocyte carcinoma (non-melanoma skin cancer). Consensus-based transplant guidelines recommend annual dermatological examination but the impact on skin cancer-related outcomes is unclear. We conducted a population-based, retrospective, inception cohort study using administrative health databases in Ontario, Canada to evaluate the association between adherence to annual dermatology assessments (time-varying exposure) and keratinocyte carcinoma-related morbidity and mortality after transplantation. Read More

    Burn wounds in the young versus the aged patient display differential immunological responses.
    Burns 2018 Jun 9. Epub 2018 Jun 9.
    Vanderbilt University Medical Center, Department of Plastic Surgery, Nashville, TN, United States; Vanderbilt University Medical Center, Department of Biomedical Engineering, Nashville, TN, United States; VA Tennessee Healthcare System, Nashville, TN, United States. Electronic address:
    Background: Individuals in the geriatric age range are more prone than younger individuals to convert their partial thickness thermal burns into full thickness injuries. We hypothesized that this often observed clinical phenomenon is strongly related to differential local injury responses mediated by the immune system.

    Materials & Methods: Skin samples from areas with partial thickness thermal burns were obtained during routine excision and grafting procedures between post burn days 2-6. Read More

    Cutibacterium acnes (Propionibacterium acnes) and acne vulgaris: a brief look at the latest updates.
    J Eur Acad Dermatol Venereol 2018 Jun;32 Suppl 2:5-14
    Laboratoire de Génie Chimique, UMR 5503, Faculty of Pharmacy, Université de Toulouse, Université Paul Sabatier, Toulouse Cedex 9, France.
    While the commensal bacterium Propionibacterium acnes (P. acnes) is involved in the maintenance of a healthy skin, it can also act as an opportunistic pathogen in acne vulgaris. The latest findings on P. Read More

    Pigmented squamous cell carcinoma presenting as longitudinal melanonychia in a transplant recipient.
    Cutis 2018 May;101(5):375-377
    Department of Dermatology, University of Illinois at Chicago, and the Department of Dermatology, Rush University, Chicago, USA.
    We report the case of a 62-year-old black man who was on a maintenance immunosuppressive regimen that included mycophenolate mofetil and cyclosporine following renal transplantation 9 years prior. He presented to the dermatology department for evaluation of a pigmented longitudinal streak on the left third finger adjacent to the lateral nail fold that had been present for several months. He noted that the streak was increasing in size, and his fingertip had recently become tender. Read More

    Three-Dimensional Stereophotogrammetric Evaluation of the Efficacy of Autologous Fat Grafting in the Treatment of Parry-Romberg Syndrome.
    J Craniofac Surg 2018 Jun 11. Epub 2018 Jun 11.
    Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano.
    Autologous fat grafting is a surgical procedure used to correct volumetric defects, atrophies, and sclerosis. Three-dimensional (3D) facial photography may enable researchers to quantify the success of surgical procedures through volumetric and surface assessments. Using 3D photography, the authors assessed the results of autologous fat grafting performed in a 15-year-old patient affected by Parry-Romberg syndrome, a rare condition resulting in progressive hemifacial atrophy of skin, subcutaneous tissues and, ultimately, bone. Read More

    Neo-glans reconstruction for penile cancer: Description of the primary technique using autologous testicular tunica vaginalis graft.
    Arab J Urol 2018 Jun 21;16(2):218-223. Epub 2018 Mar 21.
    Department of Urology, Teaching Hospital, Landesklinikum Korneuburg, Austria.
    Partial penectomy (glansectomy with/or without distal corporectomy) is an acceptable alternative for smaller distal pT3 penile carcinoma lesions in highly motivated and compliant patients. The authors describe a novel technique of neo-glans reconstruction using a tunica vaginalis (TV) testis allograft. However, due to an unclear resection margin on final histology, the patient underwent re-do surgery with a neo-glans revision using the well-established mesh split-thickness skin graft (STSG) technique. Read More

    Absence of Rejection in a Facial Allograft Recipient with a Positive Flow Crossmatch 24 Months after Induction with Rabbit Anti-Thymocyte Globulin and Anti-CD20 Monoclonal Antibody.
    Case Rep Transplant 2018 20;2018:7691072. Epub 2018 May 20.
    Hansjörg Wyss Department of Plastic Surgery, New York University Langone Health, New York, NY, USA.
    Background: Donor-specific antibodies (DSA) to human leukocyte antigen increase the risk of accelerated rejection and allograft damage and reduce the likelihood of successful transplantation. Patients with full-thickness facial burns may benefit from facial allotransplantation. However, they are at a high risk of developing DSA due to standard features of their acute care. Read More

    Emerging Functions of Regulatory T Cells in Tissue Homeostasis.
    Front Immunol 2018 25;9:883. Epub 2018 Apr 25.
    Academy of Immunology and Microbiology, Institute for Basic Science (IBS), Pohang, South Korea.
    CD4Foxp3 regulatory T-cells (Tregs) are a unique subset of helper T-cells, which regulate immune response and establish peripheral tolerance. Tregs not only maintain the tone and tenor of an immune response by dominant tolerance but, in recent years, have also been identified as key players in resolving tissue inflammation and as mediators of tissue healing. Apart from being diverse in their origin (thymic and peripheral) and location (lymphoid and tissue resident), Tregs are also phenotypically heterogeneous as per the orientation of ongoing immune response. Read More

    Transplantation preferentially induces a KLRG-1 CD127 differentiation program in antigen-specific CD8 T cells.
    Transpl Immunol 2018 Jun 8. Epub 2018 Jun 8.
    Emory Transplant Center, Atlanta 30322, Georgia. Electronic address:
    Models of infection have shaped our understanding of programmed memory T cell differentiation, yet whether these models apply to memory programming in the context of transplantation has yet to be defined. Previous work has identified differences in the response of antigen-specific CD8 T cells to cognate antigen based on the environment in which the antigen is presented. Thus, we hypothesized that programming of antigen specific CD8 T cells responding to graft and pathogen may be dissimilar. Read More

    The Management of Vacuum-assisted Closure Following Vulvectomy with Skin Grafting.
    Plast Reconstr Surg Glob Open 2018 Apr 26;6(4):e1726. Epub 2018 Apr 26.
    Department of Obstetrics and Gynecology, Michigan Medicine, Ann Arbor, Mich.
    Vulvectomies often require removal of large areas of vulvar skin, which may result in problems with wound healing, including infections and scarring. At times, skin grafting is needed following a vulvectomy, and for large excisions, a Foley catheter and rectal tube are often required. Vacuum-assisted closure (VAC) for vulvectomy, with or without skin grafting, has been used for a variety of vulvar conditions. Read More

    The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8 T cells.
    J Exp Med 2018 Jun 6. Epub 2018 Jun 6.
    Theodor Kocher Institute, University of Bern, Bern, Switzerland
    T cells are actively scanning pMHC-presenting cells in lymphoid organs and nonlymphoid tissues (NLTs) with divergent topologies and confinement. How the T cell actomyosin cytoskeleton facilitates this task in distinct environments is incompletely understood. Here, we show that lack of Myosin IXb (Myo9b), a negative regulator of the small GTPase Rho, led to increased Rho-GTP levels and cell surface stiffness in primary T cells. Read More

    Impaired Nociception in the Diabetic Mouse.
    Diabetes 2018 Jun 6. Epub 2018 Jun 6.
    Wolfson Centre for Age-Related Diseases, King's College London, London SE1 1UL, United Kingdom;
    The mechanisms responsible for painful and insensate diabetic neuropathy are not completely understood. Here, we have investigated sensory neuropathy in the mouse, a hereditary model of diabetes. Akita mice become diabetic soon after weaning, and we show that this is accompanied by an impaired mechanical and thermal nociception and a significant loss of intraepidermal nerve fibers. Read More

    Low-temperature culturing improves survival rate of tissue-engineered cardiac cell sheets.
    Biochem Biophys Rep 2018 Jul 25;14:89-97. Epub 2018 Apr 25.
    School of Advanced Science and Engineering, TWIns, Waseda University, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo 162-8480, Japan.
    Assembling three-dimensional (3D) tissues from single cells necessitates the use of various advanced technological methods because higher-density tissues require numerous complex capillary structures to supply sufficient oxygen and nutrients. Accordingly, creating healthy culture conditions to support 3D cardiac tissues requires an appropriate balance between the supplied nutrients and cell metabolism. The objective of this study was to develop a simple and efficient method for low-temperature cultivation (< 37 °C) that decreases cell metabolism for facilitating the buildup of 3D cardiac tissues. Read More

    Procurement of Extended Vascularized Skin Flaps from The Donor Enables Hand Transplantation in Severe Upper Extremity Burns: An Anatomical Study.
    Plast Reconstr Surg 2018 May 19. Epub 2018 May 19.
    Plastic Surgery Department, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, USA.
    Background: Hand transplantation in patients with severe upper extremity burns can be associated with an increased risk of exposure of vessels, tendons and nerves because of extensive skin and soft tissue deficit. This study evaluated how to reliably transfer additional extended skin flaps with a standard hand allograft.

    Methods: Twenty-five upper extremities were used. Read More

    Tumor Formation of Adult Stem Cell Transplants in Rodent Arthritic Joints.
    Mol Imaging Biol 2018 Jun 4. Epub 2018 Jun 4.
    Department of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University, 725 Welch Rd, Rm 1665, Stanford, CA, 94305-5654, USA.
    Purpose: While imaging matrix-associated stem cell transplants aimed for cartilage repair in a rodent arthritis model, we noticed that some transplants formed locally destructive tumors. The purpose of this study was to determine the cause for this tumor formation in order to avoid this complication for future transplants.

    Procedures: Adipose-derived stem cells (ADSC) isolated from subcutaneous adipose tissue were implanted into 24 osteochondral defects of the distal femur in ten athymic rats and two immunocompetent control rats. Read More

    Microbiota and Type 2 immune responses.
    Curr Opin Immunol 2018 Jun 1;54:20-27. Epub 2018 Jun 1.
    Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada.
    The trillions of microbes that colonize mucosal surfaces are critical for educating the immune system and microbial-derived signals continually shape and set the tone of immune responses. Although Type 2 immune responses are important for mediating protection from helminth infection they also underlie atopy and allergy. Microbes modulate Type 2 immune responses through effects on Type 2 cytokines, dendritic cells and regulatory T cells. Read More

    Assessment of the hepatocytic differentiation ability of human skin-derived ABCB5 stem cells.
    Exp Cell Res 2018 Jun 1. Epub 2018 Jun 1.
    Department of Visceral, Transplantation, Thoracic and Vascular Surgery, Applied Molecular Hepatology, University of Leipzig, Liebigstraße 21, 04103 Leipzig, Germany. Electronic address:
    The continuously decreasing willingness for liver donation aggravates treatment of end-stage liver diseases requiring organ transplantation as the only curative strategy. Cell therapy approaches using human hepatocytes or stem cell-derived hepatocyte-like cells may be a therapeutic option out of this dilemma. ABCB5-positive mesenchymal stromal cells from human skin featured promising potential to treat immune-mediated diseases. Read More

    Skin cancers and dermal substitutes: Is it safe? Review of the literature and presentation of a 2-stage surgical protocol for the treatment of non-melanoma skin cancers of the head in fragile patients.
    Int Wound J 2018 Jun 4. Epub 2018 Jun 4.
    UOC di Chirurgia Generale, Ospedale San Francesco, di Nuoro, Italy.
    Non-melanoma skin cancers (NMSC) represent the most common skin tumours of the head region. We describe the use of dermal substitute in a 2-stage surgery protocol for selected fragile patients to remove NMSC of the head region. A review of the literature focusing on dermal substitutes' safety after skin tumours excision is provided. Read More

    Fludarabine and rituximab with escalating doses of lenalidomide followed by lenalidomide/rituximab maintenance in previously untreated chronic lymphocytic leukaemia (CLL): the REVLIRIT CLL-5 AGMT phase I/II study.
    Ann Hematol 2018 Jun 4. Epub 2018 Jun 4.
    Department of Internal Medicine III with Hematology and Medical Oncology, Oncologic Center, Paracelsus Medical University Salzburg, Müllner-Hauptstr. 48, 5020, Salzburg, Austria.
    Despite recent advances, chemoimmunotherapy remains a standard for fit previously untreated chronic lymphocytic leukaemia patients. Lenalidomide had activity in early monotherapy trials, but tumour lysis and flare proved major obstacles in its development. We combined lenalidomide in increasing doses with six cycles of fludarabine and rituximab (FR), followed by lenalidomide/rituximab maintenance. Read More

    Cutaneous Mycobacterium chelonae infection following autologous peripheral blood stem cell transplantation for POEMS syndrome.
    J Infect Chemother 2018 May 31. Epub 2018 May 31.
    Department of Hematology, Tottori Prefectural Central Hospital, Tottori, Japan.
    Although hematopoietic stem cell transplantation (HSCT) may increase the curability of refractory hematologic diseases, it requires complication management due to a long-term immunocompromised state. We experienced a case who received an autologous peripheral blood stem cell transplantation (Auto-PBSCT) for POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) and developed cutaneous Mycobacterium chelonae infection. It is clear that attention needs to be paid to prevent bacterial, fungal and viral infection after HSCT. Read More

    Graft orientation influences meshing ratio.
    Burns 2018 May 31. Epub 2018 May 31.
    Technical University of Liberec, Department of Structure and Technologies, Studentska 2, 46117 Liberec 1, Czech Republic. Electronic address:
    Objectives: The technique of meshed skin grafting is known since 1960s. It was shown that there is a difference between the declared and real expansion ratio of the skin meshed graft. We hypothesize that the orientation of the Langer's lines in a split thickness skin graft is a key parameter in the resulting expansion ratio. Read More

    The Microbiome in Psoriasis and Psoriatic Arthritis: The Skin Perspective.
    J Rheumatol Suppl 2018 Jun;94:30-31
    From the Department of Dermatology, Erasmus University Medical Centre, Rotterdam, the Netherlands.
    Psoriasis is a chronic, inflammatory immune-mediated skin disease that affects about 2% of the world's population. In 20% of patients with psoriasis, the characteristic skin lesions are accompanied by psoriatic arthritis (PsA). Psoriasis arises in genetically predisposed individuals who have a dysregulated immune response to various environmental factors. Read More

    Deletion of a Pathogenic Mutation-Containing Exon of COL7A1 Allows Clonal Gene Editing Correction of RDEB Patient Epidermal Stem Cells.
    Mol Ther Nucleic Acids 2018 Jun 31;11:68-78. Epub 2018 Jan 31.
    Epithelial Biomedicine Division, Centro de Investigaciones Energéticas Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain; Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz, Madrid, Spain; Centro de Investigación Biomédica en Red en Enfermedades Raras (CIBERER) U714, Madrid, Spain. Electronic address:
    Recessive dystrophic epidermolysis bullosa is a severe skin fragility disease caused by loss of functional type VII collagen at the dermal-epidermal junction. A frameshift mutation in exon 80 of COL7A1 gene, c.6527insC, is highly prevalent in the Spanish patient population. Read More

    Cleft Rhinoplasty: Strategies for the Multiply Operated Nose.
    Facial Plast Surg 2018 Jun 1;34(3):290-297. Epub 2018 Jun 1.
    Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology-Head and Neck Surgery, UC Davis Medical Center, Sacramento, California.
    Rhinoplasty, as a surgical procedure to improve the appearance of the nose while preserving or improving function, is complicated and difficult to master. Revision cleft rhinoplasty offers another tier of challenge. The symmetry, proportions, and definition of the nose are affected by the native cleft deformity but also previous surgical scars, cartilage grafts, and skin excisions. Read More

    Acquired stenosis of the external auditory canal - long-term results and patient satisfaction.
    Acta Otolaryngol 2018 May 31:1-5. Epub 2018 May 31.
    a Department of Otorhinolaryngology , Medical Faculty, Head and Neck Surgery, University of Cologne , Cologne , Germany.
    Background: The surgical treatment of acquired post-inflammatory atresia of the external auditory canal (EAC) is challenging. Based on the long-term surgical experience, a modified split skin graft technique has been established at our clinic.

    Aims/objectives: The aim was to evaluate the clinical and audiological data and patient satisfaction after performing meatoplasty. Read More

    Reconstruction of Knee Defects Using Pedicled Gastrocnemius Muscle Flap with Split-Thickness Skin Grafting: A Single Surgeon's Experience with 21 Patients.
    J Knee Surg 2018 May 31. Epub 2018 May 31.
    Department of Surgery, School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama.
    Generally, reconstruction of knee defects with exposed bone, joint, tendon, and/or hardware requires a vascularized muscle flap for coverage. Although there are several surgical options for a knee defect reconstruction, the pedicled gastrocnemius muscle still remains the workhorse flap. Although this flap is commonly used for knee defect reconstruction and the technique is described very well, there is an absence of information in the literature detailing the technique of harvesting and insetting of the gastrocnemius flap step by step with illustrations. Read More

    Comparison of perioperative outcomes between endoscope-assisted technique and handheld acoustic Doppler for perforator identification in fasciocutaneous flaps.
    Medicine (Baltimore) 2018 Jun;97(22):e10849
    Department of surgery.
    The endoscopic technique has been utilized to harvest muscle flaps and detect perforators of fasciocutaneous flaps. This study aimed to compare the perioperative outcomes between the endoscope-assisted technique and handheld acoustic Doppler for perforator identification in fasciocutaneous flaps.This retrospective case-control study included patients who underwent fasciocutaneous flap reconstruction for traumatic soft tissue defects. Read More

    Paediatric electrical burn injuries: experience from a tertiary care burns unit in North India.
    Ann Burns Fire Disasters 2017 Sep;30(3):185-188
    Department of Burns and Plastic Surgery, Sawai Man Singh Medical College and Hospital, Jaipur, India.
    Electrical burn injuries in the paediatric age group constitute a small proportion of all burn cases and cause significant morbidity and long-term psychosocial impact. The objective of this study was to evaluate various aspects of electrical burn injuries in the paediatric age group in our region. A retrospective review was done of all paediatric electrical burns admitted to a tertiary care burns unit over a period of 12 months (January 2016 to December 2016). Read More

    Sulfur Mustard Exposure from Dredged Artillery Shell in a Commercial Clammer.
    Clin Pract Cases Emerg Med 2017 Nov 29;1(4):283-286. Epub 2017 Sep 29.
    Temple University Hospital, Department of Emergency Medicine, Philadelphia, Pennsylvania.
    A 40-year-old commercial fisherman presented with a blistering second degree burn to the right arm after handling a dredged and undetonated World War I-era sulfur mustard artillery shell. He sustained isolated second degree cutaneous injury requiring wound care and skin grafting. Sulfur mustard, or dichlorethylsulphide, is a vesicant chemical warfare agent that causes significant cutaneous chemical burn and is managed with burn wound care. Read More

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