885,042 results match your criteria Skin Cancer - Squamous Cell Carcinoma* Otolaryngology and Facial Plastic Surgery

Disseminated Tuberculosis in a Nigerian Adolescent with Linear IgA Bullous Dermatosis: A Case Report and Review of Literature.

West Afr J Med 2022 Jun;39(6):646-650

Department of Pathology, University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria.

Linear IgA bullous dermatosis (LABD) is an auto-immune disease affecting young children and adults, characterized by the linear deposition of IgA at the basement membrane zone with resultant complement activation and a cascade of immune reactions. There is a loss of adhesion at the dermo-epidermal junction and subsequent blister formation. It is a rare disease that has a good prognosis with adequate therapy. Read More

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Malignant Melanoma in Lagos, Nigeria: Elucidating Histopathologic Prognostic Factors.

West Afr J Med 2022 Jun;39(6):623-627

Anatomic and Molecular Pathology Department, Lagos University Teaching Hospital, Idi-Araba, Lagos State, Nigeria.

Background: Malignant melanoma (MM) is the most lethal of all cutaneous malignancies, accounting for about 79% of skin cancer related deaths. In blacks, it is associated with greater morbidity and mortality compared to Caucasians. Breslow thickness and ulceration status are two of the most important histopathologic prognostic factors in MM. Read More

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Juvenile Hyaline Fibromatosis: Report of a Case with a Novel ANTXR2 Gene Mutation.

Am J Case Rep 2022 Jun 26;23:e935921. Epub 2022 Jun 26.

Translational Medicine Research Center, Faculty of Medicine, Prince of Songkla University, Hatyai, Songkhla, Thailand.

BACKGROUND Juvenile hyaline fibromatosis is a rare autosomal recessive disorder with unknown prevalence characterized by abnormal development of hyalinized fibrous tissue usually in the skin, mucosa, bone, and often the internal organs. Here, we report the case of a 7-year-old girl from a family with ANTXR2 mutation confirming JHF. CASE REPORT The girl presented with multiple painless soft-tissue swellings affecting the ears, forehead, and scalp. Read More

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Utility of CD138/syndecan-1 immunohistochemistry for localization of plasmacytes is tissue-dependent in B6 mice.

BMC Res Notes 2022 Jun 25;15(1):219. Epub 2022 Jun 25.

Department of Pathology, University of Iowa, Iowa City, IA, USA.

Objective: Inflammation is present in many diseases and identification of immune cell infiltration is a common assessment. CD138 (syndecan-1) is a recommended immunohistochemical marker for human plasmacytes although it is also expressed in various epithelia and tumors. Similarly, CD138 is a marker for murine plasmacytes, but its tissue immunostaining is not well-defined. Read More

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Real-time ultrasound-guided versus anatomic landmark-based thoracic epidural placement: a prospective, randomized, superiority trial.

BMC Anesthesiol 2022 Jun 25;22(1):198. Epub 2022 Jun 25.

Department of Anaesthesia and Intensive Care, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, SAR, China.

Background: Thoracic epidural placement (TEP) using the conventional anatomic landmark-based technique is technically challenging, may require multiple attempts, and is associated with a high failure rate (12-40%). We hypothesized that real-time ultrasound guidance would be superior in the "first-pass" success rate of TEP, when compared with the conventional technique.

Methods: This prospective, randomized, superiority trial was conducted in a University hospital, and recruited 96 patients undergoing elective major abdominal or thoracic surgery and scheduled to receive a TEP for postoperative analgesia. Read More

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Estrogen Action and Gut Microbiome Metabolism in Dermal Health.

Dermatol Ther (Heidelb) 2022 Jun 25. Epub 2022 Jun 25.

e-Bio Corp., 4 Stonewall Lane, Woodbridge, CT, 06525, USA.

Emerging scientific advances in microbial research linking estrogens and the gut-skin microbiome in reference to dermal health are featured in this narrative review of journal reports and reviews from January 2018 through February 2022. Background information on advances in microbial research along with defining the microbiota and microbiome is presented in brief. The development of and factors that influence the gut microbiome in health and disease as well as the intrinsic and extrinsic factors influencing the skin microbiome and skin aging are summarized. Read More

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Eruptive melanocytic naevi following initiation of elexacaftor/ivacaftor/tezacaftor for cystic fibrosis.

J Cyst Fibros 2022 Jun 22. Epub 2022 Jun 22.

Adult CF Unit, Liverpool Heart and Chest Hospital, Thomas Drive, Liverpool L14 3PE, UK; Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.

A 29 year old woman with cystic fibrosis (CF) presented to CF clinic following the sudden development of over 200 pigmented naevi located predominately on the trunk and limbs 3 months after commencing elexacaftor/tezacaftor/ivacaftor, a novel triple-therapy CFTR modulator therapy for CF. Skin biopsy confirmed benign naevi and the clinical presentation was consistent with eruptive melanocytic naevi. Elexacaftor/tezacaftor/ivacaftor received marketing authorisation in August 2020 and this is the first report of associated naevi. Read More

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Cardiovascular events after a dramatic reduction of HbA1c in hospitalized subjects with type 2 diabetes and high long-term glucose exposure.

J Diabetes Complications 2022 Jun 21:108234. Epub 2022 Jun 21.

Nutrition-Diabetology, CHU de Bordeaux, Hôpital Haut-Lévêque, F-33600 Pessac, France.

Objective: In long-lasting diabetes, a dramatic reduction of HbA1c can precede adverse events such as worsening retinopathies or painful neuropathies. We have now analyzed its possible link with later cardiovascular events in subjects with type 2 diabetes, according to their long-term glucose exposure evaluated by skin autofluorescence (SAF) measured with an AGE-READER (Diagnoptics, Groningen, The Netherland).

Research Design And Methods: We studied retrospectively a cohort of patients hospitalized for uncontrolled and/or complicated type 2 diabetes from 2009 to 2017. Read More

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Alopecia areata: Recent advances and emerging therapies.

Ann Dermatol Venereol 2022 Jun 22. Epub 2022 Jun 22.

Univ. Bordeaux, CNRS UMR5164, ImmunoConCept, F-33000 Bordeaux, France.

Alopecia areata is an acquired, chronic, non-scarring hair disorder of the skin affecting 0.5-2% of the general population worldwide. Multiple mechanisms are involved in the disease, namely genetic predisposition, environmental triggers, impaired hair growth, and altered inflammatory and immune responses. Read More

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Apigenin in Cancer Prevention and Therapy: A Systematic Review and Meta-Analysis of Animal Models.

Crit Rev Oncol Hematol 2022 Jun 22:103751. Epub 2022 Jun 22.

Molecular Cancer Genetics & Translational Research Lab, Section of Genetics, Department of Zoology, Aligarh Muslim University, Aligarh-202002, India. Electronic address:

Background: Apigenin is being increasingly recognized as a cancer chemopreventive agent. We aimed to investigate the anticancer effects of Apigenin in in-vivo studies to know its present research status and how close or how far it is from the clinics.

Methods: Several electronic databases such as PubMed, Springer, Cochrane, and ctri. Read More

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Sappanwood-derived polyphenolic antidote of amyloidal toxins achieved detoxification via inhibition/reversion of amyloidal fibrillation.

Int J Biol Macromol 2022 Jun 22. Epub 2022 Jun 22.

Department of Bioproducts and Biosystems Engineering, University of Minnesota, St Paul, MN 55108, USA.

The formidable virulence of methicillin-resistant staphylococcus aureus (MRSA) have thrown great challenges to biomedicine, which mainly derives from their autocrine phenol-soluble modulins (PSMs) toxins, especially the most toxic member termed phenol-soluble modulins α3 (PSMα3). PSMα3 cytotoxicity is attributed to its amyloidal fibrillation and subsequent formation of cross-α sheet fibrils. Inspired by the multiple biological activity of Sappanwood, herein, we adopted brazilin, a natural polyphenolic compound originated from Caesalpinia sappan, as a potential antidote of PSMα3 toxins, and attempted to prove that the regulation of PSMα3 fibrillation was an effective alexipharmic way for MRSA infections. Read More

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Microbiota-Independent Spontaneous Dermatitis Associated With Increased Sebaceous Lipid Production in Tmem79-Deficient Mice.

J Invest Dermatol 2022 Jun 22. Epub 2022 Jun 22.

Department of Dermatology, Keio University School of Medicine, Tokyo, Japan; Laboratory for Skin Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. Electronic address:

TMEM79 is a predisposing gene for atopic dermatitis (AD). Tmem79-deficient mice develop spontaneous dermatitis in a biphasic pattern. The 1-phase dermatitis is unique, as it occurs independent of microbiota status, whereas the 2-phase dermatitis is microbiota-dependent. Read More

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Real-time, In Vivo Skin Cancer Triage by Laser-Induced Plasma Spectroscopy Combined with Deep Learning-based Diagnostic Algorithm.

J Am Acad Dermatol 2022 Jun 22. Epub 2022 Jun 22.

Department of Human-Computer Interaction, Hanyang University, Seoul, South Korea.

Background: Although various skin cancer detection devices have been proposed, most of them are not used owing to their insufficient diagnostic accuracies. Laser-induced plasma spectroscopy (LIPS) can noninvasively extract biochemical information of skin lesions using an ultrashort pulsed laser.

Objective: To investigate the diagnostic accuracy and safety of a real-time noninvasive in vivo skin cancer diagnostics utilizing non-discrete molecular LIPS combined with a deep neural network (DNN)-based diagnostic algorithm. Read More

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Clinical and dermoscopic findings of benign longitudinal melanonychia due to melanocytic activation differ by skin type and predict likelihood of nail matrix biopsy.

J Am Acad Dermatol 2022 Jun 22. Epub 2022 Jun 22.

Department of Dermatology, Weill Cornell Medicine New York, NY, USA. Electronic address:

Background: Longitudinal melanonychia (LM) is a common dermatologic finding in clinical practice with a broad differential diagnosis. Melanocytic activation is the most common LM etiology.

Objective: To investigate clinical and dermoscopic differences of benign LM based on Fitzpatrick skin type and in biopsied vs. Read More

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The in vitro and in vivo antibacterial activities of uniflorous honey from a medical plant, Scrophularia ningpoensis Hemsl., and characterization of its chemical profile with UPLC-MS/MS.

J Ethnopharmacol 2022 Jun 22:115499. Epub 2022 Jun 22.

College of Animal Sciences (College of Bee Science), Fujian Agriculture and Forestry University, Fuzhou, 350002, China; College of Marine Sciences, Fujian Agriculture and Forestry University, Fuzhou, 350002, China. Electronic address:

Ethnopharmacological Relevance: According to the Compendium of Materia Medica, honey has been used as a traditional medicine in treatment against mucositis, tinea, hemorrhoids and psoriasis. In complementary medicine, due to its significant antimicrobial activity, honey has been widely used as a remedy for skin wounds and gastrohelcosis for thousands of years.

Aim Of The Study: This study is aimed at exploring the antimicrobial activity and mechanisms of honey sourced from medical plants, and revealing the composition-activity relationship, to facilitate their complementary and alternative application in the therapy of bacterial infectious diseases. Read More

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Melatonin as an adjuvant treatment modality with doxorubicin.

Biochimie 2022 Jun 22. Epub 2022 Jun 22.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, I.R. Iran. Electronic address:

Combination chemotherapy seems to be a beneficial choice for some cancer patients particularly when the drugs target different processes of oncogenesis; patients treated with combination therapies sometimes have a better prognosis than those treated with single drug chemotherapy. However, research has shown that this is not always the case, and this approach may only increase toxicity without having a significant effect in augmenting the antitumor actions of the drugs. Doxorubicin (Dox) is one of the most common chemotherapy drugs used to treat many types of cancer, but it also has serious side effects, such as cardiotoxicity, skin necrosis, testicular toxicity, and nephrotoxicity. Read More

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A case report of ulceroglandular tularemia caused by Francisella tularensis subsp. holarctica in Iran.

Acta Trop 2022 Jun 22:106570. Epub 2022 Jun 22.

National Reference Laboratory for Plague, Tularemia and Q fever, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Akanlu, Kabudar Ahang, Hamadan, Iran; Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Tehran, Iran. Electronic address:

Background: Tularemia is a zoonotic disease that has been reported in many countries of the Northern Hemisphere. However, in some countries, such as Iran, this disease has been neglected by the health care system, and it is under-reported.

Case Presentation: Here we report an unusual case of ulceroglandular tularemia occurring in a 35-year-old woman who presented with a skin lesion of the left flank, inguinal lymphadenopathy, and an abdominal abscess. Read More

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The Optimal Cesarean Skin Incision in Patients with Super Obesity.

Am J Perinatol 2022 Jun 25. Epub 2022 Jun 25.

Department of Obstetrics and Gynecology and Reproductive Sciences, University of Maryland Medical Center, Baltimore, United States.

Objective To evaluate if supraumbilical midline vertical incision performed in patients with a hanging pannus (umbilicus at the level of the pubic bone) is a reasonable alternative to Pfannenstiel in patients with Body Mass Index (BMI) ≥ 50 kg/m2 undergoing cesarean delivery. Methods Retrospective cohort study in patients with BMI ≥50 kg/m2 undergoing cesarean delivery at a single center from 2016 to 2020. Study groups were Pfannenstiel VS supraumbilical vertical skin incision. Read More

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"Nurturing future leaders in aesthetics: Now is the time".

Facial Plast Surg 2022 Jun 25. Epub 2022 Jun 25.

Plastic Surgery, Plastic Surgery, Thessaloniki, Greece.

There is a need for a specialist pathway or progression in aesthetic medicine for aesthetic physicians. A structured program for specialised training in non-surgical facial aesthetics to empower physicians is the need of the hour. The pharmaceutical companies currently provide training sessions, taking considerable initiatives to train aesthetic professionals. Read More

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Artemisia Leaf Extract protects against neuron toxicity by TRPML1 activation and promoting autophagy/mitophagy clearance in both in vitro and in vivo models of MPP+/MPTP-induced Parkinson's disease.

Phytomedicine 2022 Jun 15;104:154250. Epub 2022 Jun 15.

Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan. Electronic address:

Background: Parkinson's disease (PD) is a neurodegenerative disorder involving the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Cellular clearance mechanisms, including the autophagy-lysosome pathway, are commonly affected in the pathogenesis of PD. The lysosomal Ca channel mucolipin TRP channel 1 (TRPML1) is one of the most important proteins involved in the regulation of autophagy. Read More

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A comparative study, distribution, predicted no-effect concentration (PNEC) and contamination assessment of phenol with heavy metal contents in two coastal areas on the Egyptian Mediterranean Sea coast.

Mar Environ Res 2022 Jun 16;179:105687. Epub 2022 Jun 16.

National Institute of Oceanography and Fisheries, NIOF, Egypt.

This study comparing the expected pollution status of phenol along with heavy metals in sediments of two economic regions on the Mediterranean Sea coast using equilibrium partitioning method (EPM) as well as exposure of fishermen and populations to these sediments through ingestion and skin contact while swimming. El-Dekhila (ED) and Abu Talat (AT) regions were different in sediment texture and pollution sources. The expected ecological hazards of phenol in the studied areas were carried out using the equilibrium partitioning method (EPM) by which the partition coefficient of organic carbon-water, K (logK> 0. Read More

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Childhood maltreatment, traumatic experiences, and posttraumatic stress disorder in pathological skin picking: An online case-control study.

Gen Hosp Psychiatry 2022 Jun 16;78:9-13. Epub 2022 Jun 16.

Center for Psychotherapy Research, University Hospital Heidelberg, Heidelberg, Germany.

Objective: Although traumatic stress including childhood maltreatment (CM) has a profound impact on mental health, its relation to pathological skin picking (PSP) has been understudied and results remain inconclusive. Likewise, posttraumatic stress disorder (PTSD) as the most typical sequelae of traumatic stress has hardly been investigated in those with PSP. The objective of our online case-control study was to shed further light on this issue. Read More

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Case series of inguinal pedicle-flap to cover hand ulcers: Our experience from northern Tanzania.

Int J Surg Case Rep 2022 Jun 21;96:107339. Epub 2022 Jun 21.

Department of General Surgery, Kilimanjaro Christian Medical Centre, P O Box 3010, Moshi, Tanzania; Kilimanjaro Christian Medical University College, Faculty of Medicine, P O Box 2240, Moshi, Tanzania.

Introduction And Importance: The superficial circumflex iliac artery perforator flap is a widely used and acceptable option of free tissue transfer for small and large defects due to its ease of dissection and adjustable pedicle length.

Case Presentation: Herein we present our experience with two similar cases of hand ulcers with differing aetiologies that were managed successfully at our tertiary centre by general surgeons to cover the defects in order to salvage the hand.

Clinical Discussion: The pedicle groin flap was first described in 1972 and still indicated and used widely in hand resurfacing. Read More

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Primary vs patch-based skin repair for in-utero spina bifida repair.

Ultrasound Obstet Gynecol 2022 Jun 25. Epub 2022 Jun 25.

The Fetal Center, Children's Memorial Hermann Hospital, Department of Obstetrics and Gynecology, McGovern Medical School, The University of Texas Health Science Center at Houston, Texas, USA.

Objectives: In-utero spina bifida closure of large defects is often challenging, requiring tissue graft for watertight skin closure. No prior studies have compared the primary skin closure with the patch-based repair. Our objective was to compare neonatal and one-year outcomes associated with these two types of skin closure for in-utero spina bifida repair. Read More

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Fumarate hydratase is a novel gene for familial non-medullary thyroid cancer.

J Clin Endocrinol Metab 2022 Jun 25. Epub 2022 Jun 25.

Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia.

Context: the majority of cases of epithelial cell-derived thyroid cancer are sporadic. Familial non-medullary thyroid cancer (FNMTC) occurs in about 5-9% of cases, either as a part of known syndromes such as Cowden syndrome or in the form of familial clustering of 2 or more affected family members. Hereditary Leiomyoma and renal cell cancer (HLRCC) syndrome is a rare familial cancer syndrome. Read More

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Cytokine-producing B-cell balance associates with skin fibrosis in patients with systemic sclerosis.

J Dermatol 2022 Jun 25. Epub 2022 Jun 25.

Department of Dermatology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.

Systemic sclerosis (SSc) is an autoimmune disease characterized by skin and lung fibrosis. Over 90% of patients with SSc are positive for autoantibodies. In addition, the serum levels of B-cell activating factor, a potent B-cell stimulator, are correlated with SSc severity and activity. Read More

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Imputation of the major histocompatibility complex region identifies major independent variants associated with bullous pemphigoid and dermatomyositis in Han Chinese.

J Dermatol 2022 Jun 25. Epub 2022 Jun 25.

Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

As autoimmune skin diseases, both bullous pemphigoid (BP) and dermatomyositis (DM) show significant associations with the major histocompatibility complex (MHC) region. In fact, the coexistence of BP and DM has been previously reported. Therefore, we hypothesized that there may be a potential genetic correlation between BP and DM. Read More

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Improving the applicability of the thermo-physiological human simulator by correcting its local set point skin temperatures.

Int J Biometeorol 2022 Jun 25. Epub 2022 Jun 25.

College of Fashion and Design, Donghua University, West Yan'an Road 1882, Shanghai, 200051, China.

The thermo-physiological human simulator has been used in many regions for estimating thermal behavior of the locals. The applicability of the human simulator to populations from different regions is, however, questioned due to its lack of consideration for the ethnic diversities in thermoregulation. This study checked the potential of improving the applicability of the Newton human simulator, one of the most popular simulators, by correcting its local set point skin temperatures according to the target population (Chinese as an example). Read More

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Using structural topic modelling to reveal patterns in reports on opioid drugs in a pharmacovigilance database.

Pharmacoepidemiol Drug Saf 2022 Jun 25. Epub 2022 Jun 25.

Netherlands Pharmacovigilance Centre Lareb, 's Hertogenbosch, the Netherlands.

Background: Adverse drug reaction (ADR) reports in pharmacovigilance databases often contain coded information and large amounts of unstructured or semi-structured information in plain text format. The unstructured format and sheer volume of these data often render them neglected. Structural topic modelling (STM) represents a potentially insightful way of harnessing these valuable data and to detect grouping or themes in spontaneous reports to aid signal detection. Read More

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A Genomic Meta-Analysis of Clinical Variables and Their Association with Intrinsic Molecular Subsets in Systemic Sclerosis.

Rheumatology (Oxford) 2022 Jun 25. Epub 2022 Jun 25.

Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Lebanon, NH, 03756, USA.

Objectives: Four intrinsic molecular subsets (Inflammatory, Fibroproliferative, Limited, Normal-like) have previously been identified in systemic sclerosis (SSc) and are characterized by unique gene expression signatures and pathways. The intrinsic subsets have been linked to improvement with specific therapies. Here, we investigated associations between baseline demographics and intrinsic molecular subsets in a meta-analysis of published datasets. Read More

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