803,267 results match your criteria Skin Cancer - Merkel Cell Carcinoma* Otolaryngology and Facial Plastic Surgery


Pseudoaneurysm of the Superficial Temporal Artery After Intracranial Pressure Monitoring Device Placement: Case Report of a Rare Complication.

Oper Neurosurg (Hagerstown) 2020 Jun 5. Epub 2020 Jun 5.

Department of Neurological Surgery, University of Washington, Seattle, Washington.

Background And Importance: Pseudoaneurysms involving the superficial temporal artery (STA), either iatrogenic or caused by direct trauma, are rare. The STA is prone to injury due to its long course throughout the scalp. Injuries can cause cosmetic defects and/or skin breakdown leading to further complications. Read More

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http://dx.doi.org/10.1093/ons/opaa151DOI Listing

Insights into the DNA methylation of sea cucumber Apostichopus japonicus in response to skin ulceration syndrome infection.

Fish Shellfish Immunol 2020 Jun 2. Epub 2020 Jun 2.

Liaoning Key Lab of Marine Fishery Molecular Biology, Liaoning Ocean and Fisheries Science Research Institute, Dalian, Liaoning 116023, PR China.

DNA methylation is an important epigenetic modification that regulates gene expression in many biological processes, including immune response. In this study, whole-genome bisulfite sequencing (WGBS) was carried out on healthy body wall (HB) and skin ulceration syndrome (SUS) infected body wall (SFB) to gain insights into the epigenetic regulatory mechanism in sea cucumber Apostichopus japonicus. After comparison, a total of 116,522 differentially methylated regions (DMRs) were obtained including 67,269 hyper-methylated and 49,253 hypo-methylated DMRs (p < 0. Read More

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http://dx.doi.org/10.1016/j.fsi.2020.05.005DOI Listing

Efficacy and Patient-Reported Outcomes from a Phase IIb, Randomized Clinical Trial of Tapinarof Cream for the Treatment of Adolescents and Adults with Atopic Dermatitis.

J Am Acad Dermatol 2020 Jun 2. Epub 2020 Jun 2.

SKiN Centre for Dermatology, Probity Medical Research and Queen's University, Peterborough, ON, Canada.

Background: Tapinarof is a topical therapeutic aryl hydrocarbon receptor modulating agent (TAMA) under investigation for atopic dermatitis (AD) and psoriasis treatment.

Methods: Phase IIb, double-blind, vehicle-controlled study randomized adolescents and adults with AD to receive tapinarof cream 0.5%, 1%, or vehicle, once (QD) or twice daily (BID) for 12 weeks with 4-week follow-up. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.05.135DOI Listing

CHILBLAIN-LIKE ACRAL LESIONS DURING THE COVID-19 PANDEMIC ("COVID TOES"): HISTOLOGIC, IMMUNOFLUORESCENCE AND IMMUNOHISTOCHEMICAL STUDY OF 17 CASES.

J Am Acad Dermatol 2020 Jun 2. Epub 2020 Jun 2.

Department of Dermatology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon.

Background: During the COVID-19 pandemic, several acral chilblain-like skin lesions (CBLL) were observed in young patients with suspected, but mostly unconfirmed, infection with SARS-CoV-2. The histopathological aspect of these lesions is as yet poorly known.

Objective: To investigate the pathologic features of CBLL. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.05.145DOI Listing

A retrospective case series evaluating the efficacy of pre-operative, intra-incisional antibiotic prophylaxis in Mohs micrographic surgery: an effective method to reduce surgical site infections and minimize systemic antibiotic use.

J Am Acad Dermatol 2020 Jun 2. Epub 2020 Jun 2.

Zitelli and Brodland Skin Cancer Center, Pittsburgh, PA 15232; University of Pittsburgh Medical Center, Pittsburgh, PA 15232.

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http://dx.doi.org/10.1016/j.jaad.2020.05.146DOI Listing

Infection as a Cardiovascular Trigger: Associations Between Different Organ System Infections and Cardiovascular Events.

Am J Med 2020 Jun 2. Epub 2020 Jun 2.

Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:

Background: Infection may be an acute precipitant of cardiovascular events. However, the relationships between different types of infection and cardiovascular events are less known. Our objective was to determine if exposure to infections of different organ systems in different time periods increases risk of myocardial infarction or venous thromboembolism. Read More

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http://dx.doi.org/10.1016/j.amjmed.2020.04.033DOI Listing

Congenital syphilis, the great imitator-case report and review.

Lancet Infect Dis 2020 Jun 2. Epub 2020 Jun 2.

Department of Pediatric Immunology, Rheumatology, and Infectious Diseases, Amsterdam UMC, locatie AMC, Amsterdam, Netherlands.

Syphilis is caused by a spirochaete bacterium called Treponema pallidum. Vertical transmission of spirochaetes can lead to congenital infection of the fetus in pregnant women who are inadequately treated or not treated at all, causing various clinical manifestations including stillbirth and neonatal death, cutaneous and visceral manifestations, or asymptomatic infection. We present a severe case of syphilis in a 3-month-old boy with skin lesions, portal hypertension, and anaemia. Read More

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http://dx.doi.org/10.1016/S1473-3099(20)30268-1DOI Listing

Skinny Fat Cells Stimulate Wound Healing.

Cell Stem Cell 2020 Jun;26(6):801-803

Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

In this issue of Cell Stem Cell, Shook et al. (2020) reveal that dermal adipocytes regulate skin wound repair via release of fatty acids that promote macrophage recruitment and accelerated revascularization. Furthermore, mature dermal adipocytes dedifferentiate into migratory extracellularmatrix-producing myofibroblasts. Read More

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http://dx.doi.org/10.1016/j.stem.2020.04.021DOI Listing

ASIC1a does not play a role in evoking the metabolic component of the exercise pressor reflex in a rat model of peripheral artery disease.

Am J Physiol Heart Circ Physiol 2020 Jun 5. Epub 2020 Jun 5.

Heart and Vascular Institute, Penn State College of Medicine, United States.

The role of the ASIC1a in evoking the exercise pressor reflex in rats with simulated peripheral artery disease is unknown. This prompted us to determine if ASIC1a plays a role in evoking the exaggerated exercise pressor reflex in decerebrated rats with simulated peripheral artery disease. To simulate peripheral artery disease, we ligated the left femoral artery 72h before the experiment. Read More

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http://dx.doi.org/10.1152/ajpheart.00257.2020DOI Listing

Challenges faced by patients with morphea in the era of SARS-CoV-2.

J Dermatolog Treat 2020 Jun 5:1-6. Epub 2020 Jun 5.

Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1080/09546634.2020.1775771DOI Listing

Development and Characterization of Squalene-Loaded Topical Agar-Based Emulgel Scaffold: Wound Healing Potential in Full-Thickness Burn Model.

Int J Low Extrem Wounds 2020 Jun 5:1534734620921629. Epub 2020 Jun 5.

Vels Institute of Science, Technology & Advanced Studies, Chennai, India.

Full-thickness burns pose a major challenge for clinicians to handle because of their restricted self-healing ability. Even though several approaches have been implemented for repairing these burnt skin tissue defects, all of them had unsatisfactory outcomes. Moreover, during recent years, skin tissue engineering techniques have emerged as a promising approach to improve skin tissue regeneration and overcome the shortcomings of the traditional approaches. Read More

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http://dx.doi.org/10.1177/1534734620921629DOI Listing

Wound Healing Activities of L Extract and Milk-Cream Ointment on Second-Degree Burns of Rat Skin.

Int J Low Extrem Wounds 2020 Jun 5:1534734620921589. Epub 2020 Jun 5.

Kermanshah University of Medical Sciences, Kermanshah, Iran.

Skin burn is a major health problem in the community and seeking new and suitable treatment is suggested. In this regard, traditional remedies were consider in many countries. Regarding clinical application of herbal medicine in the healing of burn wounds, the present study was designed to evaluate the effect of ( L) extract with milk-cream on the healing of second-degree burn in a rat model. Read More

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http://dx.doi.org/10.1177/1534734620921589DOI Listing

Cognitive behavioral therapy as an adjuvant therapy in Acne excoriée: a randomized controlled clinical trial.

J Dermatolog Treat 2020 Jun 5:1-23. Epub 2020 Jun 5.

Mashhad University of Medical Sciences, Mashhad, Iran.

: Acne excoriée (AE) is a difficult challenge in dermatology practice. AE is mostly associated with some psychiatric disorders particularly mood disorders. Thus, patients generally continue to manipulate their lesions. Read More

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http://dx.doi.org/10.1080/09546634.2020.1776207DOI Listing

Nanomedicine for the treatment of rheumatoid arthritis.

Mol Pharm 2020 Jun 5. Epub 2020 Jun 5.

Rheumatoid arthritis (RA) is a chronic autoimmune disease that results in severe inflammatory microenvironments in the joint tissues. In clinics, disease-modifying anti-rheumatic drugs (DMARDs) are generally prescribed to patients with RA, but their long-term use often shows toxicity in some organs such as gastro-intestine, skin, and kidney, and immunosuppression-mediated infection. Nanomedicine has emerged as a new therapeutic strategy to efficiently localize the drugs in inflamed joints for the treatment of RA. Read More

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http://dx.doi.org/10.1021/acs.molpharmaceut.0c00295DOI Listing

Control of myeloid cell density in barrier tissues.

FEBS J 2020 Jun 5. Epub 2020 Jun 5.

Department of Pediatrics and Adolescent Medicine, Medical Center, University of Freiburg, Faculty of Medicine, 79106, Freiburg, Germany.

The interface between the mammalian host and its environment is formed by barrier tissues, e.g. of the skin, the respiratory and the intestinal tracts. Read More

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http://dx.doi.org/10.1111/febs.15436DOI Listing

Melanoma defies 'lockdown': ongoing detection during Covid-19 in central London.

Clin Exp Dermatol 2020 Jun 5. Epub 2020 Jun 5.

Dermatology Department, University College London Hospitals NHS Trust, London, United Kingdom.

The COVID-19 pandemic has presented significant challenges for Dermatology services, particularly the diagnosis and management of malignant melanoma (MM). Early detection and definitive surgical treatment are key to improving MM prognosis, and in England there is a suspected skin cancer referral pathway that facilitates specialist Dermatology assessment within two weeks. Here, we describe the impact of COVID-19 on MM detection, based on data from the a Dermatology Department in central London. Read More

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http://dx.doi.org/10.1111/ced.14324DOI Listing

Screening for prevalence of current TB disease and latent TB infection in type 2 diabetes mellitus patients attending a diabetic clinic in an Indian tertiary care hospital.

PLoS One 2020 5;15(6):e0233385. Epub 2020 Jun 5.

Department of Pulmonary Medicine, Christian Medical College, Vellore, Tamil Nadu, India.

Background: Diabetes triples the risk of developing tuberculosis (TB). This study was designed to determine the prevalence of past and current TB disease and Latent TB infection (LTBI) in type 2 Diabetes Mellitus (NIDDM) patients.

Design: This was a prospective descriptive study on all NIDDM patients attending a Diabetic clinic. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233385PLOS

Epidemiological consequences of enduring strain-specific immunity requiring repeated episodes of infection.

PLoS Comput Biol 2020 Jun 5;16(6):e1007182. Epub 2020 Jun 5.

Victorian Infectious Diseases Reference Laboratory Epidemiology Unit at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne and Royal Melbourne Hospital, Victoria, Australia.

Group A Streptococcus (GAS) skin infections are caused by a diverse array of strain types and are highly prevalent in disadvantaged populations. The role of strain-specific immunity in preventing GAS infections is poorly understood, representing a critical knowledge gap in vaccine development. A recent GAS murine challenge study showed evidence that sterilising strain-specific and enduring immunity required two skin infections by the same GAS strain within three weeks. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1007182DOI Listing

TATTOO-ASSOCIATED CASES OF POSTERIOR SEGMENT UVEITIS WITH VOGT-KOYANAGI-HARADA DISEASE-LIKE FEATURES.

Retin Cases Brief Rep 2020 Jun 3. Epub 2020 Jun 3.

Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland.

Purpose: To present two patients with treatment-naïve posterior segment uveitis with Vogt-Koyanagi-Harada-like features associated with tattoo-related inflammatory skin changes.

Methods: Retrospective report of two cases.

Results: Using clinical history and multimodal imaging, a diagnosis of posterior segment uveitis with Vogt-Koyanagi-Harada-like features was made in association with tattoo skin changes in both patients. Read More

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http://dx.doi.org/10.1097/ICB.0000000000001007DOI Listing

Effects of Granulocyte Macrophage Colony-Stimulating Factor Inhibition on the Skin/Nerve Cell Model In Vitro.

J Craniofac Surg 2020 Jun 4. Epub 2020 Jun 4.

Department of Plastic Surgery, Korea University College of Medicine, Seoul, Korea.

The present study is based on the concept of neuro-aging and how it may affect surrounding skin cells. It has been shown that many factors play a significant role in skin homeostasis by interfering with various cytokines, either through activation or inhibition. Granulocyte macrophage colony-stimulating factor (GM-CSF) is generally recognized as an inflammatory cytokine, and our previous study has shown its effects on neuronal senescence after ultraviolet (UV) irradiation of skin cells. Read More

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http://dx.doi.org/10.1097/SCS.0000000000006411DOI Listing

Somatic Symptom Perception from a Predictive Coding Perspective - an Empirical Test Using the Thermal Grill Illusion.

Psychosom Med 2020 Jun 2. Epub 2020 Jun 2.

Department for Clinical Psychology, Psychotherapy, and Experimental Psychopathology, Johannes Gutenberg University Mainz, Germany.

Objective: In a predictive coding perspective, symptom perceptions result from an integration of pre-existing information in memory with sensory input. Physical symptoms can therefore reflect the relative predominance of either sensory input or pre-existing information. In this study, we used the thermal grill illusion (TGI), which applies interlaced warm and cool temperatures to the skin to create a paradoxical heat-pain experience. Read More

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http://dx.doi.org/10.1097/PSY.0000000000000824DOI Listing

Clinical manifestations and genetic analysis of 4 children with chronic granulomatous disease.

Medicine (Baltimore) 2020 Jun;99(23):e20599

Pediatricians are unfamiliar with chronic granulomatous disease (CGD) because of its rarity and paucity of available data, potentially leading to misdiagnosis, late treatments, and mortality. The main purpose of this study was to summarize the clinical manifestations and auxiliary examination findings of four children with CGD confirmed by genetic testing.This was a case series study of children hospitalized at the Pediatric Respiratory Department of Shandong Provincial Hospital. Read More

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http://dx.doi.org/10.1097/MD.0000000000020599DOI Listing

Autologous blood or autologous serum acupoint injection therapy for psoriasis vulgaris: A protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2020 Jun;99(23):e20555

Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Background: Psoriasis vulgaris (PV) is a refractory and relapsing skin disease that affects the physical and mental health of patients and leads to poor quality of life. Current conventional systemic therapy shows a large side effect, which can not be used for a long time, easy to relapse after drug withdrawal, long-term efficacy is poor. At present, traditional Chinese medicine treatment of psoriasis vulgaris effective, can alleviate symptoms, improve the quality of life, stabilize the condition, prolong the remission period. Read More

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http://dx.doi.org/10.1097/MD.0000000000020555DOI Listing

Effects of tyrosine kinase inhibitor therapy on skin toxicity and skin-related quality of life in patients with lung cancer: An observational study.

Medicine (Baltimore) 2020 Jun;99(23):e20510

School of Nursing, College of Medicine, Chang Gung University.

Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy is the primary treatment option for patients with non-small cell lung cancer (NSCLC). However, one of the major adverse effects associated with this therapy is skin toxicity, which impacts the patient's quality of life. This study aimed to describe the severities and locations of skin toxicity, and to analyze their association with the quality of life in patients with advanced NSCLC who received EGFR-TKI therapy as first-line treatment. Read More

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http://dx.doi.org/10.1097/MD.0000000000020510DOI Listing

Acute compartment syndrome in children; beware of "silent" compartment syndrome: A CARE-compliant case report.

Medicine (Baltimore) 2020 Jun;99(23):e20504

Department of Pediatric Surgery, University Children's Hospital Basel (UKBB), Basel, Switzerland.

Rationale: Acute compartment syndrome (ACS) is a feared complication following traumatic injuries. We describe the occurrence of silent ACS of the hand in a 2-year old patient with atypical symptoms.

Patient Concerns: Our patient experienced massive swelling but minimal pain of the hand after a heavy bistro table with a stone tabletop had fallen on the right hand. Read More

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http://dx.doi.org/10.1097/MD.0000000000020504DOI Listing

Effect of heat-clearing and detoxifying Chinese medicines combined with conventional therapy on mild hand, foot, and mouth disease with fever: An individual patient data meta-analysis.

Medicine (Baltimore) 2020 Jun;99(23):e20473

China Academy of Chinese Medical Sciences, Beijing, China.

Background: In China, heat-clearing and detoxifying Chinese medicines combined with conventional therapy are commonly applied to treat the mild hand, foot, and mouth disease (HFMD). However, there is lack of solid evidence on the efficacy and safety of such therapies.

Methods: We conducted a pooled analysis with individual patient data from 5 strictly randomized controlled clinical trials to assess the efficacy and safety of this combination therapy for mild HFMD. Read More

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http://dx.doi.org/10.1097/MD.0000000000020473DOI Listing

Galectin-1 and Galectin-3 Expression in Lesional Skin of Patients With Systemic Sclerosis-Association With Disease Severity.

J Clin Rheumatol 2020 Jun 4. Epub 2020 Jun 4.

Department of Pathology, Hospital Universitario Austral, Pilar, Argentina.

: Galectin-1 (Gal-1) and galectin-3 (Gal-3) are carbohydrate-binding proteins involved in normal processes, autoimmunity, and cancer. Increased serum Gal-3 levels in scleroderma were associated with active disease, vasculopathy, and mortality.

Objectives: The aim of this study was to evaluate Gal-1 and Gal-3 expression in the lesional skin of patients with scleroderma regarding disease severity and organ involvement. Read More

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http://dx.doi.org/10.1097/RHU.0000000000001367DOI Listing

Generalized Progressive Papulonodular Skin Lesions in a 37-Year-Old Man: Challenge.

Am J Dermatopathol 2020 Jun 4. Epub 2020 Jun 4.

Department of Laboratory Medicine & Pathology, Hamad Medical Corporation, Doha, Qatar.

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http://dx.doi.org/10.1097/DAD.0000000000001610DOI Listing

Differences Between Squamous Intraepithelial Lesions of the Vulva and the Cervix.

J Low Genit Tract Dis 2020 Jun 2. Epub 2020 Jun 2.

University of Auckland, Auckland, NZ.

The Lower Anogenital Squamous Terminology project and subsequent publication have grouped preinvasive human papillomavirus-associated squamous intraepithelial lesions of the lower genital tract and adjacent skin as a single entity. We are concerned that as a result of this grouping, some of the clinically relevant differences may not be taken into consideration. We describe differences between high-grade squamous intraepithelial lesion of the vulva and cervix (vulvar intraepithelial neoplasia and cervical intraepithelial neoplasia), in embryology (arising from ectoderm vs mesoderm), clinical presentations (symptoms or signs due to many vulvar lesions vs abnormal cytology), examination techniques and diagnosis (clinical examination of potentially widely involved areas vs colposcopy of the transformation zone), natural history, management, and follow-up requirements (long-term clinical assessment vs cytology and human papillomavirus testing). Read More

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http://dx.doi.org/10.1097/LGT.0000000000000545DOI Listing

Two-stage Reconstruction Using a Free Jejunum/Ileum Flap After Total Esophagectomy.

Ann Plast Surg 2020 Jun 2. Epub 2020 Jun 2.

From the Department of Plastic and Reconstructive Surgery, The University of Tokyo, Bunkyo-ku.

Background: Reconstruction after esophagectomy is conventionally performed with a gastric conduit. However, in cases where a gastric conduit is unavailable, reconstructive procedures vary in terms of flap type, operative timing, and conduit route. Single-stage surgery is associated with a long operation time and high surgical stress, resulting in perioperative mortality. Read More

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http://dx.doi.org/10.1097/SAP.0000000000002421DOI Listing

In-hospital Outcomes of Left Ventricular Assist Devices (LVAD) Patients Undergoing Noncardiac Surgery.

ASAIO J 2020 Jun 4. Epub 2020 Jun 4.

From the Division of Cardiovascular Diseases, Section of Heart Failure and Transplant, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

An increasing number of stage D heart failure patients are supported with left ventricular assist devices (LVADs), and the management of LVAD patients who require noncardiac surgery (NCS) presents unique challenges. Using the 2010-2014 National Inpatient Sample, we identified all adult cases of LVAD patients undergoing noncardiac surgeries using ICD-9-CM codes. We estimated inpatient mortality, bleeding complications, stroke, length of stay (LOS), and cost of hospitalization of the admissions related to NCS using mixed effects logistic and linear mixed regressions, respectively. Read More

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http://dx.doi.org/10.1097/MAT.0000000000001205DOI Listing

Ethanol-Based Disinfectants Containing Urea May Reduce Soap Sensitivity.

Authors:
Marie Lodén

Dermatitis 2020 Jun 2. Epub 2020 Jun 2.

From the Eviderm Institute AB, Solna, Sweden.

Background: The use of disinfectants is crucial to preventing the spread of nosocomial infections in health care workers. As many as 25 applications of hand disinfectants is a realistic default value during a working day. However, alcohol-based hand disinfectants may weaken skin barrier function and induce dryness and eczema, which decrease their acceptance. Read More

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http://dx.doi.org/10.1097/DER.0000000000000612DOI Listing

Exosomes: A New Effective Non-Surgical Therapy for Androgenetic Alopecia?

Skinmed 2020 1;18(2):96-100. Epub 2020 Mar 1.

Cosmetic Skin and Surgery Center, Englewood Cliffs, NJ.

Exosome therapy is a promising new approach for the treatment of hair loss. Current treatments for androgenetic alopecia, the most common form of hair loss, fall short of providing satisfactory efficacy with minimal side effects; thus, the fact that exosome therapy delivers impressive hair growth with no reported adverse events makes this therapy an attractive avenue to be explored; nevertheless, due to the novelty of this treatment, clinical trials to confirm its efficacy and safety are lacking. The current state of knowledge that is publicly available on the efficacy of exosome therapy for treatment of hair loss is reviewed, and the potential of exosomes as an alternate therapy for hair restoration is discussed. Read More

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Device-related pressure ulcers in community settings.

Authors:
Alison Schofield

Br J Community Nurs 2020 Jun;25(Sup6):S14-S18

Tissue Viability Team Clinical Nurse Specialist North Lincolnshire and Goole NHS Foundation Trust.

Understanding the differential diagnosis between device-related pressure ulcers (DRPUs) and pressure ulcers ensures that appropriate prevention, management and intervention plans are identified. National reporting systems now include DRPUs alongside other categories of pressure ulcers listed by international pressure ulcer advisory panels. Medical devices are not the only cause of DRPUs, and, in the community setting, other objects can also cause pressure ulcers, such as spectacles and hearing aids. Read More

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http://dx.doi.org/10.12968/bjcn.2020.25.Sup6.S14DOI Listing

Why we should be avoiding periorificial mimetic muscles when injecting tissue fillers.

J Cosmet Dermatol 2020 Jun 5. Epub 2020 Jun 5.

All Saints Clinic, Double Bay, New South Wales, Australia.

Background: Tissue fillers are generally safe and well tolerated by patients. However, complications do occur, and may be very severe, such as intravascular injection (with occasional residual tissue loss, visual and neurological sequelae) and late nodularity and swelling. Methods to lessen the likelihood of complications have been the subject of much recent literature. Read More

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http://dx.doi.org/10.1111/jocd.13531DOI Listing

Classification of aplasia cutis congenita: a twenty-five-year review of cases presenting to a tertiary paediatric dermatology department.

Clin Exp Dermatol 2020 Jun 5. Epub 2020 Jun 5.

Department of Dermatology, Birmingham Children's Hospital, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, United Kingdom.

Background: Aplasia cutis congenita (ACC) is a rare, congenital disorder characterized by localised or widespread absence of skin at birth with heterogeneous clinical presentation. The classification proposed by Frieden in 1986 is widely used.

Aim: To establish whether, 34 years on, the Frieden classification still meets our needs. Read More

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http://dx.doi.org/10.1111/ced.14331DOI Listing

The study of hair follicle counts from scalp histopathology in the Thai population.

Int J Dermatol 2020 Jun 5. Epub 2020 Jun 5.

Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background: The horizontal section of a scalp specimen offers an advantage over a vertical section by providing quantitative information. The reference data for hair counts in Asians, including Thais, are inconclusive. We aimed to determine the normal values of hair counts in scalp biopsy specimens in the Thai population. Read More

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http://dx.doi.org/10.1111/ijd.14989DOI Listing

Healing of deep dermal burns by allogeneic mesenchymal stromal cell transplantation.

Int J Dermatol 2020 Jun 5. Epub 2020 Jun 5.

Unidad de Terapia Celular - Laboratorio de Patología Celular y Molecular, Instituto Venezolano de Investigaciones Científicas (IVIC), Apartado, Venezuela.

Background: Deep dermal and full-thickness burns are not only difficult to treat, but they are also associated with significant morbidity and mortality. Recent reports have proposed the use of mesenchymal stromal cells (MSCs) for inducing tissue repair in burn injuries.

Objective: We aim to evaluate the effect of allogeneic MSC transplantation on full-thickness burns with delayed healing. Read More

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http://dx.doi.org/10.1111/ijd.14949DOI Listing

Potential forensic implications of therapy - a traditional Indonesian therapy associated with neck bruising.

Med Sci Law 2020 Jun 5:25802420926867. Epub 2020 Jun 5.

Faculty of Medicine, The University of Adelaide, Australia.

is a traditional Indonesian treatment involving abrading the skin over various parts of the body with a blunt object such as a coin or a piece of ginger which may create suspicious injuries. Here, the case of a 30-year-old woman who had undergone therapy is reported. She was complaining of retro-sternal pain and epigastric discomfort and subsequently became markedly short of breath and died. Read More

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http://dx.doi.org/10.1177/0025802420926867DOI Listing

Current technical surgical practice of emergency appendicectomy: a cross-sectional survey of surgical registrars in the UK.

Ann R Coll Surg Engl 2020 Jun 5:1-5. Epub 2020 Jun 5.

West Suffolk Hospital, Bury St Edmunds, United Kingdom.

Introduction: Appendicectomy remains one of the most commonly performed procedures in general surgery. The aim of this study was to explore variation in operative techniques of an appendicectomy among surgical registrars in England.

Materials And Methods: An anonymised survey was sent out to surgical registrars in the UK via email and social media. Read More

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http://dx.doi.org/10.1308/rcsann.2020.0123DOI Listing

Occupational exposure to blood and body fluids among primary healthcare workers in Johannesburg health district: High rate of underreporting.

S Afr Fam Pract (2004) 2020 May 14;62(1):e1-e7. Epub 2020 May 14.

Department of Family Medicine, University of the Witwatersrand, Johannesburg.

Background: Healthcare workers (HCWs) are at risk of bloodborne infections from sharp instrument injuries and skin and mucous membrane exposures to contaminated blood and body fluids (BBF). While these have clinical and occupational health implications, little is known about BBF exposure and its reporting pattern in South African primary healthcare (PHC). The aim of this study was to determine the rate of BBF exposure, the extent of reporting and the reasons for not reporting among HCWs in PHC facilities in Johannesburg, South Africa. Read More

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http://dx.doi.org/10.4102/safp.v62i1.5027DOI Listing

Management of bacterial skin and soft tissue infections.

Przegl Epidemiol 2020 ;74(1):89-107

Jagiellonian University Medical College, Department of Infectious and Tropical Diseases.

Skin and soft tissue infections (SSTIs) are a group of diseases usually caused by bacteria, and connected with different clinical picture, course, and prognosis. The increasing incidence of SSTIs is associated mainly with aging of the population, the increasing number of metabolic diseases, especially diabetes mellitus, as well as cardiovascular diseases. Although SSTIs are often benign and usually does not require medical consultations, some of them may cause a systemic infection. Read More

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http://dx.doi.org/10.32394/pe.74.07DOI Listing
January 2020

Electrochemiluminescent sensors as a screening strategy for psychoactive substances within biological matrices.

Analyst 2020 Jun 5. Epub 2020 Jun 5.

WESTChem Department of Pure and Applied Chemistry, University of Strathclyde, Technology and Innovation Centre, 99 George Street, Glasgow, G1 1RD, UK.

With the rapid growth and appearance of novel psychoactive substances (NPS) onto the global drug market, the need for alternative screening methodologies for implementation within clinical environments is substantial. The immunoassay methods currently in use are inadequate for this new drug trend with the potential for misdiagnosis and subsequent administration of incorrect patient treatment increased. This contribution illustrates a strong proof-of-concept for the use of electrochemiluminescence (ECL) as a screening methodology for NPS within biological fluids, using the hallucinogen scopolamine as a model compound. Read More

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http://dx.doi.org/10.1039/d0an00846jDOI Listing

Walkthrough Sanitization Gates for COVID-19: A Preventive Measure or Public Health Concern?

Am J Trop Med Hyg 2020 Jun 3. Epub 2020 Jun 3.

Department of Clinical Pharmacy, College of Pharmacy, Jouf University, Al-Jouf, Sakaka, Kingdom of Saudi Arabia.

As the COVID-19 pandemic continues to gain momentum around the world, several measures are being put in place to control its spread. One such effort includes the installation walkthrough sanitization gates to disinfect passersby and prevent cross infection. However, there is lack of clinical evidence on the effectiveness of these walkthrough gates to contain COVID-19. Read More

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http://dx.doi.org/10.4269/ajtmh.20-0533DOI Listing

Dalbavancin for the Treatment of Complicated Gram-Positive Skin and Soft Tissue Infections.

Int J Low Extrem Wounds 2020 Jun 5:1534734620921677. Epub 2020 Jun 5.

University Hospital of Alexandroupolis, Alexandroupolis, Greece.

New antimicrobial agents have been developed to treat infections caused by methicillin-resistant and other multidrug-resistant pathogens. Dalbavancin is a novel semisynthetic lipoglycopeptide antibiotic, particularly active against methicillin-resistant . Due to its unique pharmacological characteristics and longer half-life, it can be administered once-weekly or every 15 days and in outpatient setting. Read More

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http://dx.doi.org/10.1177/1534734620921677DOI Listing

Management of Plaque Psoriasis With Biologic Therapies in Women of Child-Bearing Potential Consensus Paper.

J Cutan Med Surg 2020 Jun 5:1203475420928376. Epub 2020 Jun 5.

Department of Medicine, McMaster University, Hamilton, ON, Canada.

Background: Plaque psoriasis (PsO) is a chronic inflammatory disease that often presents at peak reproductive age in women of child-bearing potential (WOCBP). With the emergence of biologic therapies to treat PsO, guidance on disease management in WOCBP is needed to inform treatment decisions before, during, and after pregnancy.

Objectives: To develop a practical, up-to-date consensus document, based on available evidence and expert opinion where evidence was lacking, in order to guide both Canadian and international clinicians treating PsO in WOCBP. Read More

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http://dx.doi.org/10.1177/1203475420928376DOI Listing

Non-invasive Electroarthrography Measures Load-Induced Cartilage Streaming Potentials via Electrodes Placed on Skin Surrounding an Articular Joint.

Cartilage 2020 Jun 5:1947603520928583. Epub 2020 Jun 5.

Comparative Orthopaedic Research Laboratory, Department of Clinical Studies, University of Guelph, Guelph, Ontario, Canada.

Objective: We aimed to demonstrate that electroarthrography (EAG) measures streaming potentials originating in the cartilage extracellular matrix during load bearing through electrodes adhered to skin surrounding an articular joint.

Design: Equine metacarpophalangeal joints were subjected to simulated physiological loads while (1) replacing synovial fluid with immersion buffers of different electrolyte concentrations and (2) directly degrading cartilage with trypsin.

Results: An inverse relationship between ionic strength and EAG coefficient was detected. Read More

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http://dx.doi.org/10.1177/1947603520928583DOI Listing

Radical vulvectomy with right gluteal and left medial thigh V-Y advancement flap reconstruction.

J Turk Ger Gynecol Assoc 2020 Jun 5. Epub 2020 Jun 5.

Department of Gynecologic Oncology, University of Groningen, Groningen, The Netherlands.

Vulvar cancer is rarely seen. Vulva corresponds to the external female genitalia and it is in association with the perineum with the intersection of urinary, sexual and anal systems. The deep anatomy of the perineum in the urogenital and anogenital triangle should be well-known by the gynecological oncologists. Read More

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http://dx.doi.org/10.4274/jtgga.galenos.2020.2020.0055DOI Listing

Global Coronavirus Pandemic (SARS CoV-2): Past, Present, And Future Of Pediatric Dermatology.

Dermatol Ther 2020 Jun 4:e13767. Epub 2020 Jun 4.

Dermatological Clinic Department of Clinical and Molecular Sciences, Polytechnic University of the Marche Region, Ancona, Italy.

Two months have passed since the World Health Organization (WHO) declared the pandemic of the Coronavirus Disease 19 (COVID-19), caused by the SARS CoV-2 virus, on March 11, 2020. Medical and healthcare workers have continued to be on the frontline to defeat this disease, however, continual changes are being made to their working habits which are proving to be difficult. Although the skin is not the main target of the SARS CoV-2 infection, it is strongly involved both directly and indirectly, in many aspects of dermatological disease management, and particularly in pediatric dermatology. Read More

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http://dx.doi.org/10.1111/dth.13767DOI Listing

Histology of skin lesions establishes that the vesicular rash associated with COVID-19 is not "varicella-like".

J Eur Acad Dermatol Venereol 2020 Jun 5. Epub 2020 Jun 5.

Hôpital Pasteur, Colmar, France.

Several articles recently reported a "varicella-like" rash in patients with COVID-19 [1,2]. We observed similar cases at our institution. However, although we agree that the clinical picture is original, we reject that "varicella-like" denomination since clinical presentation, as well as some histologic features that we wish to report here for the first time, make it clearly different from varicella. Read More

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http://dx.doi.org/10.1111/jdv.16706DOI Listing
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