756,187 results match your criteria Skin Cancer - Merkel Cell Carcinoma* Otolaryngology and Facial Plastic Surgery


Spanish Validation of the GEPARD Questionnaire for the Detection of Psoriatic Arthritis in Argentinian Patients with Psoriasis.

Dermatology 2019 Jan 17:1-6. Epub 2019 Jan 17.

Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Background/objective: Psoriatic arthritis (PsA) is preceded by psoriasis in approximately 80% of cases. Dermatologists are pivotal for early detection. It is important to have simple tools that allow the detection of PsA in patients with skin psoriasis. Read More

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http://dx.doi.org/10.1159/000495983DOI Listing
January 2019

Children environmental exposure to particulate matter and polycyclic aromatic hydrocarbons and biomonitoring in school environments: A review on indoor and outdoor exposure levels, major sources and health impacts.

Environ Int 2019 Jan 14;124:180-204. Epub 2019 Jan 14.

REQUIMTE/LAQV, Instituto Superior de Engenharia do Instituto Politécnico do Porto, Porto, Portugal. Electronic address:

Children, an important vulnerable group, spend most of their time at schools (up to 10 h per day, mostly indoors) and the respective air quality may significantly impact on children health. Thus, this work reviews the published studies on children biomonitoring and environmental exposure to particulate matter (PM) and polycyclic aromatic hydrocarbons (PAHs) at school microenvironments (indoors and outdoors), major sources and potential health risks. A total of 28, 35, and 31% of the studies reported levels that exceeded the international outdoor ambient air guidelines for PM, PM, and benzo(a)pyrene, respectively. Read More

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http://dx.doi.org/10.1016/j.envint.2018.12.052DOI Listing
January 2019

Role of Galphaq in pathogenesis of psoriasis, a new mechanism about the immune regulation in psoriasis.

Int Immunopharmacol 2019 Jan 14;68:185-192. Epub 2019 Jan 14.

Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Xiamen University, Xiamen, China. Electronic address:

Psoriasis (PSO) is a chronic inflammatory skin disease characterized with skin lesions and abnormal keratinocyte proliferation. The immune dysregulation is involved in the pathogenesis of PSO. However, the detail of immune regulation in PSO is still not very clear. Read More

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http://dx.doi.org/10.1016/j.intimp.2018.12.054DOI Listing
January 2019

Confirmatory factor analysis of the SLEEP-50 Questionnaire in Trichotillomania (Hair-Pulling Disorder) and Excoriation (Skin-Picking) Disorder.

Psychiatry Res 2019 Jan 7;273:197-205. Epub 2019 Jan 7.

Division of Child and Adolescent Psychiatry, University of California, Los Angeles, CA, USA.

The study objective was to perform a confirmatory factor analysis of the SLEEP-50 Questionnaire (SLEEP-50) in Trichotillomania (Hair-Pulling Disorder) and Excoriation (Skin-Picking) Disorder and compare sleep complaints in adults with Trichotillomania, Excoriation Disorder and non-affected controls. Participants were 234 adults with Trichotillomania, 170 with Excoriation Disorder, and 146 non-affected controls. Participants rated sleep using the SLEEP-50 and Pittsburgh Sleep Quality Index (PSQI). Read More

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http://dx.doi.org/10.1016/j.psychres.2019.01.022DOI Listing
January 2019

Anisotropic cellular forces support mechanical integrity of the Stratum Corneum barrier.

J Mech Behav Biomed Mater 2018 Dec 27;92:11-23. Epub 2018 Dec 27.

L'Oréal Research and Innovation, Aulnay-sous-Bois, France. Electronic address:

The protective function of biological surfaces that are exposed to the exterior of living organisms is the result of a complex arrangement and interaction of cellular components. This is the case for the most external cornified layer of skin, the stratum corneum (SC). This layer is made of corneocytes, the elementary 'flat bricks' that are held together through adhesive junctions. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2018.12.027DOI Listing
December 2018

Automated detection of erythema migrans and other confounding skin lesions via deep learning.

Comput Biol Med 2018 Dec 18;105:151-156. Epub 2018 Dec 18.

Lyme Disease Research Center, Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, United States.

Lyme disease can lead to neurological, cardiac, and rheumatologic complications when untreated. Timely recognition of the erythema migrans rash of acute Lyme disease by patients and clinicians is crucial to early diagnosis and treatment. Our objective in this study was to develop deep learning approaches using deep convolutional neural networks for detecting acute Lyme disease from erythema migrans images of varying quality and acquisition conditions. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2018.12.007DOI Listing
December 2018

Drug-in-micelles-in-liposomes (DiMiL) systems as a novel approach to prevent drug leakage from deformable liposomes.

Eur J Pharm Sci 2019 Jan 14. Epub 2019 Jan 14.

Department of Pharmaceutical Sciences, University of Milan, via G. Colombo 71, 20133 Milan, Italy.

Deformable liposomes (DL) are successfully exploited to enhance the skin penetration of several compounds. Nevertheless, the "soft" nature of the bilayer favors the drug leakage, mainly in the case of hydrophobic compounds. This work aimed to develop a suitable strategy to stabilize the lipid bilayer, without compromising the deformability properties of DL. Read More

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http://dx.doi.org/10.1016/j.ejps.2019.01.013DOI Listing
January 2019

Clinicopathologic, misdiagnosis and survival differences between clinically amelanotic melanomas and pigmented melanomas.

J Am Acad Dermatol 2019 Jan 14. Epub 2019 Jan 14.

Pigmented Lesion Clinic and Cutaneous Oncology Program, Department of Dermatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. Electronic address:

Background: Amelanotic malignant melanoma (AMM) is challenging to diagnose. Clinical risk factors for AMM are not well defined.

Objective: To investigate clinicopathologic, misdiagnosis and survival differences between AMM versus (vs. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.01.012DOI Listing
January 2019

Microneedling with dermaroller 192 needles along with 5-fluorouracil solution in the treatment of stable vitiligo.

J Am Acad Dermatol 2019 Jan 14. Epub 2019 Jan 14.

Department Of Skin and VD, Jhalawar, Rajasthan, India.

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http://dx.doi.org/10.1016/j.jaad.2018.12.066DOI Listing
January 2019

Fabrication of microporous inorganic microneedles by centrifugal casting method for transdermal extraction and delivery.

Int J Pharm 2019 Jan 14. Epub 2019 Jan 14.

Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran; Department of Developmental Biology, University of Science and Culture, Tehran, Iran. Electronic address:

Microneedle patches have been widely used as transdermal transport systems because of their painless and easy application. Marked rigidity, strength, biocompatibility, and physiological stability are unique features of microneedles fabricated from ceramic materials to be used as microneedle patches. However, the conventional ceramic microneedles are typically dense structures with limited free space for biomolecule loading. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2018.12.089DOI Listing
January 2019

Inhibitory checkpoint receptors control CD8+ resident memory T cells to prevent skin allergy.

J Allergy Clin Immunol 2019 Jan 14. Epub 2019 Jan 14.

CIRI, International Center for Infectiology Research, Université de Lyon, Lyon, France; INSERM, U1111, Lyon, France; Ecole Normale Supérieure de Lyon, Lyon, France; Université Lyon 1, Centre International de Recherche en Infectiologie, Lyon, France; CNRS, UMR 5308, Lyon, France. Electronic address:

Background: Tissue-resident memory T cells (Trm) are detrimental in numerous chronic inflammatory diseases, including allergic contact dermatitis (ACD).

Objectives: To analyze the contribution of Trm to the chronicity and severity of ACD and to define the local parameters regulating their development and functions.

Methods: We used an experimental model of ACD, i. Read More

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http://dx.doi.org/10.1016/j.jaci.2018.11.048DOI Listing
January 2019

Pectoral muscle atrophy after axillary artery cannulation for aortic arch surgery.

Semin Thorac Cardiovasc Surg 2019 Jan 14. Epub 2019 Jan 14.

Department of Cardiovascular Surgery, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.

Objectives: To investigate postoperative pectoral atrophy in 141 patients undergoing aortic arch surgery involving bilateral axillary artery cannulations with side grafts.

Methods: The depth from the skin to the axillary artery surrounding the thoracoacromial artery (zone 1), and the thicknesses of pectoralis major (zone 2) and pectoralis minor (zone 3) were measured by computed tomography before surgery, at 1 and 6 months after surgery, and at the most recent follow-up assessment (PostT2) (mean = 41 months, range 11-75 months). Based on the median value (47. Read More

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http://dx.doi.org/10.1053/j.semtcvs.2019.01.013DOI Listing
January 2019

Non-invasive monitoring of subclinical and clinical actinic keratosis of face and scalp under topical treatment with ingenolmebutate gel 150 mcg/gby means of reflectance confocal microscopy and optical coherence tomography: new perspectives and comparison of diagnostic techniques.

J Biophotonics 2019 Jan 17:e201800391. Epub 2019 Jan 17.

Department of Dermatology and Allergy, University Hospital Munich, Munich, Germany.

Actinic keratosis (AKs) corresponds to the earliest stage of in-situ squamous cell carcinoma and arises on chronically sun-exposed skin. Around the clinically evident AKs, the apparently healthy epidermis may contain different grades of atypia that can be detected by non-invasive imaging techniques such as reflectance confocal microscopy (RCM) and optical coherence tomography (OCT). Subclinical actinic keratosis (sAKs) have captured increasing interest as a potential target of field therapies. Read More

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http://dx.doi.org/10.1002/jbio.201800391DOI Listing
January 2019

Dosimetric comparison of VMAT with integrated skin flash to 3D field-in-field tangents for left breast irradiation.

J Appl Clin Med Phys 2019 Jan 17. Epub 2019 Jan 17.

Department of Radiation Oncology, University of Toledo Medical Center, Toledo, OH, USA.

Volumetric modulated arc therapy (VMAT) has been implemented for left breast irradiation to reduce prescription dose to the heart and improve dose homogeneity across the targeted breast. Our in-house method requires application of a bolus during the optimization process with a target outside of the body, then removing the bolus during the final calculation in order to incorporate skin flash in VMAT plans. To quantify the dosimetric trade-offs between traditional 3D field-in-field tangents and VMAT with integrated skin flash for these patients, we compared nine consecutive patients who recently received radiation to their entire left breast but not their regional lymphatics. Read More

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http://dx.doi.org/10.1002/acm2.12527DOI Listing
January 2019

Tropisetron via α7 nicotinic acetylcholine receptor suppresses tumor necrosis factor-α-mediated cell responses of human keratinocytes.

Exp Dermatol 2019 Jan 17. Epub 2019 Jan 17.

Dept. of Dermatology, University of Münster, Münster, Germany.

Tropisetron is a serotonin receptor (5-HT-R)-modulating agent and approved as an antiemetic for patients undergoing chemotherapy. In the gut it acts via specific serotonin receptors, 5-HT -R, to elicit its beneficial effects against nausea. We investigated whether tropisetron can affect inflammatory cell responses of human primary epidermal keratinocytes (NHK) which are key cells in the regulation of skin homeostasis. Read More

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http://dx.doi.org/10.1111/exd.13883DOI Listing
January 2019

Cervical cutaneous sclerosis: the stomach is not far from the skin.

J Eur Acad Dermatol Venereol 2019 Jan 17. Epub 2019 Jan 17.

Department of Dermatology, Assistance Publique - Hôpitaux de Paris, Henri Mondor Hospital, Créteil, France.

Here in, we report a particular case presenting an erythematous and indurated plaque of the neck that has revealed gastric linitis plastic (GLP). An 80-year-old man presented to the Department of Dermatology in November 2015 with a 2-month history of a sclerotic inflammatory infiltration of the skin located on the anterior cervical region (Figure 1a, b) associated with a general impaired condition. Medical history revealed a partial gastrectomy for peptic ulcer 30 years ago. Read More

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http://dx.doi.org/10.1111/jdv.15432DOI Listing
January 2019

Environmental factors associated with the presence of Vibrionaceae in tropical cage-cultured marine fishes.

J Aquat Anim Health 2019 Jan 17. Epub 2019 Jan 17.

Laboratory of Marine Biotechnology, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia.

This study investigates the environmental factors associated with the presence of Vibrionaceae in economically important cage-cultured tropical marine fish; the Asian Seabass, Red Snapper and Hybrid Grouper. Fish samplings were conducted at monthly intervals between December 2016 and August 2017. The body weight and length of individual fish were measured, while the skin, eye, liver and kidney were sampled for bacterial isolation and identification. Read More

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http://dx.doi.org/10.1002/aah.10062DOI Listing
January 2019

Short exposures and glove protection from (meth)acrylates in nail beauticians - thoughts on a rising concern.

Contact Dermatitis 2019 Jan 17. Epub 2019 Jan 17.

Dermatology Department, Coimbra University Hospital, Coimbra, Portugal.

Allergic contact dermatitis (ACD) from (meth)acrylates in nail aesthetics is a rising concern, namely in the occupational setting (1)(2). Some technicians may have to abandon the job, as allergen avoidance is difficult (3). Aiming to evaluate the capacity of gloves to protect from occupational ACD we performed patch tests with glove fragments placed between the allergens and patients' skin for different time periods, in patients with occupational ACD and positive patch tests to the (meth)acrylates and negative patch tests to gloves. Read More

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http://dx.doi.org/10.1111/cod.13222DOI Listing
January 2019

Allergic contact dermatitis caused by isopropyl methylphenol, a new hapten.

Contact Dermatitis 2019 Jan 17. Epub 2019 Jan 17.

Division of Gynecology, Hanamizuki Clinic, Ushiku, Ibaraki, Japan.

Isopropyl methylphenol (synonym: o-cymen-5-ol, Biosol; CAS no. 3228-02-2) (Fig. 1) is used as anti-mold and general anti-microbial agent, as preservative, and as antioxidant. Read More

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http://dx.doi.org/10.1111/cod.13217DOI Listing
January 2019

Topical Ambroxol 20% for the Treatment of Classical Trigeminal Neuralgia - A New Option? Initial Clinical Case Observations.

Headache 2019 Jan 17. Epub 2019 Jan 17.

Migraine and Headache Clinic, Königstein, Germany.

Background: Trigeminal neuralgia is difficult to treat and shows upregulation of sodium channels. The expectorant ambroxol acts as a strong local anesthetic, about 40 times stronger than lidocaine. It preferentially inhibits the channel subtype Na 1. Read More

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http://dx.doi.org/10.1111/head.13475DOI Listing
January 2019

Neonatal Skin Emergencies.

Pediatr Ann 2019 Jan;48(1):e36-e42

Although the majority of neonatal skin rashes can be safely monitored without intervention, there are a significant few that are dermatologic emergencies. When called to assess a neonate, it is important to distinguish what requires immediate diagnosis and treatment from those that represent benign etiologies. The skin may be the first clue to certain infections such as herpes simplex virus, syphilis, varicella, cytomegalovirus, fungal infections, and staphylococcal scalded skin syndrome, all of which require immediate testing and some of which may lead to severe sequelae. Read More

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http://dx.doi.org/10.3928/19382359-20181210-03DOI Listing
January 2019

Uncommon Neonatal Skin Lesions.

Pediatr Ann 2019 Jan;48(1):e30-e35

Certain rashes and cutaneous lesions in a newborn can be clues to more concerning diseases and conditions if recognized and evaluated promptly. Langerhans cell histiocytosis, cutaneous forms of cancer (such as leukemia cutis, neuroblastoma, and rhabdomyosarcoma), developmental abnormalities such as neural tube or spinal dysraphism, and aplasia cutis congenita, nutritional deficiency, and immunodeficiency all have a range of cutaneous findings that will be reviewed herein to guide diagnosis and management. [Pediatr Ann. Read More

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http://dx.doi.org/10.3928/19382359-20181212-02DOI Listing
January 2019

Common Neonatal Skin Lesions: Melanocytic Nevi, Pigment Alterations, and Nonmelanocytic Nevi.

Pediatr Ann 2019 Jan;48(1):e23-e29

Birthmarks are common in the healthy population and are generally harmless. Certain presentations, however, raise concern for associated syndromes or potential complications. It is important for pediatricians to be familiar with both harmless and potentially concerning birthmarks. Read More

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http://dx.doi.org/10.3928/19382359-20181207-01DOI Listing
January 2019

Common Neonatal Rashes.

Pediatr Ann 2019 Jan;48(1):e16-e22

Skin eruptions are commonly encountered in the neonatal and infant period and can be a source of concern for providers and parents alike. We present a brief, clinically focused discussion on topics commonly encountered by the pediatrician with a focus on pearls of knowledge to help distinguish diseases from one another and from more serious conditions. We review miliaria, transient neonatal pustular melanosis, neonatal cephalic pustulosis, erythema toxicum neonatorum, diaper dermatitis, seborrheic dermatitis, and atopic dermatitis. Read More

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http://dx.doi.org/10.3928/19382359-20181206-01DOI Listing
January 2019

Newborn Skin Care.

Pediatr Ann 2019 Jan;48(1):e11-e15

The skin serves as a unique barrier from the outside world and undergoes critical changes during its development and maturation. This article reviews evidence-based recommendations for the routine care of newborn skin that should be integrated into the pediatrician's practice. [Pediatr Ann. Read More

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http://dx.doi.org/10.3928/19382359-20181211-01DOI Listing
January 2019

Chronological changes in rhinitis symptoms present in school-aged children with allergic sensitization.

PLoS One 2019 17;14(1):e0210840. Epub 2019 Jan 17.

Department of Otorhinolaryngology, Jeju National University School of Medicine, Jeju, South Korea.

Introduction: It is difficult to accurately predict the natural course of allergic rhinitis (AR), because it is affected by a wide variety of environmental influences, as well as genetic predisposition. Considering the high prevalence of allergic rhinitis in children and adolescents, caregivers should be given appropriate information regarding the disease course. This study aimed to understand the prognosis of allergic rhinitis by examining the relationship between allergic sensitization and rhinitis symptoms during this developmental period. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210840PLOS
January 2019

Development of a preliminary in vitro drug screening assay based on a newly established culturing system for pre-adult fifth-stage Onchocerca volvulus worms.

PLoS Negl Trop Dis 2019 Jan 17;13(1):e0007108. Epub 2019 Jan 17.

Molecular Parasitology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, United States of America.

Background: The human filarial parasite Onchocerca volvulus is the causative agent of onchocerciasis (river blindness). It causes blindness in 270,000 individuals with an additional 6.5 million suffering from severe skin pathologies. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007108DOI Listing
January 2019

Exercise intensity independently modulates thermal behavior during exercise recovery, but not during exercise.

J Appl Physiol (1985) 2019 Jan 17. Epub 2019 Jan 17.

Exercise and Nutrition Sciences, University at Buffalo, United States.

We tested the hypothesis that thermal behavior is greater during and following high compared to moderate intensity exercise. In a 27°C, 20% relative humidity environment, 20 participants (10 females) cycled for 30 min at moderate (53±6% VOpeak) or high (78±6% VOpeak) intensity, followed by 120 min recovery. Mean skin and core temperatures and mean skin wettedness were recorded continuously. Read More

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http://dx.doi.org/10.1152/japplphysiol.00992.2018DOI Listing
January 2019

Local arginase inhibition does not modulate cutaneous vasodilation or sweating in young and older men during exercise.

J Appl Physiol (1985) 2019 Jan 17. Epub 2019 Jan 17.

School of Human Kinetics, University of Ottawa, Canada.

Age-related impairments in cutaneous vascular conductance (CVC) and sweat rate (SR) during exercise may result from increased arginase activity, which can attenuate endogenous nitric oxide (NO) production. We therefore evaluated whether arginase inhibition modulates these heat loss responses in young (n=9, 23±3 years) and older (n=9, 66 ± 6 years) men during two 30-min bouts of moderate-intensity cycling (Ex1 and Ex2) in the heat (35°C). CVC and SR were measured at forearm skin sites perfused with: 1) lactated Ringer's (Control); 2) N-nitro--arginine methyl ester (L-NAME, NO synthase-inhibited); or 3) N-hydroxy-nor-Arginine and S-(2-boronoethyl)-L-cysteine (Nor-NOHA + BEC, arginase-inhibited). Read More

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http://dx.doi.org/10.1152/japplphysiol.00657.2018DOI Listing
January 2019

Skin Cancer Associated Genodermatoses: A Literature Review.

Acta Derm Venereol 2019 Jan 17. Epub 2019 Jan 17.

Department of Dermatology and Allergy Centre, Odense University Hospital, DK-5000 Odense, Denmark.

Skin cancer has become the most common type of cancer worldwide as a result of environmental exposure and medical treatments. A small group of patients are genetically predisposed to skin cancer and this article is intended as a diagnostic tool when encountering patients with multiple skin cancer lesions. The disorders are described with clinical characteristics, genetics and management. Read More

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http://dx.doi.org/10.2340/00015555-3123DOI Listing
January 2019

Low- vs. Middle-dose Total Skin Electron Beam Therapy for Mycosis Fungoides: An Efficiency-based Retrospective Survey of Skin Response.

Acta Derm Venereol 2019 Jan 17. Epub 2019 Jan 17.

Department of Dermatology, INSERM U1058 University of Montpellier, FR-34295 Montpellier, France.

Optimal doses of total skin electron beam therapy for mycosis fungoides remain to be established. Clinical efficiency and adverse effects of middle-dose (25 Gy) vs. low-dose (10-12 Gy) total skin electron beam therapy were retrospectively compared in a series of 14 and 12 mycosis fungoides, respectively. Read More

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http://dx.doi.org/10.2340/00015555-3124DOI Listing
January 2019

Effect of Topical Rapamycin 1% on Multiple Trichoepitheliomas.

Acta Derm Venereol 2019 Jan 17. Epub 2019 Jan 17.

Department of Dermatology, Reference Centre for Rare Skin Diseases, Paul Sabatier University, FR- 31400 Toulouse, France.

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http://dx.doi.org/10.2340/00015555-3116DOI Listing
January 2019

Multiple Lesions in Irradiated Skin.

JAMA Oncol 2019 Jan 17. Epub 2019 Jan 17.

Division of Dermatology, Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky.

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http://dx.doi.org/10.1001/jamaoncol.2018.5852DOI Listing
January 2019

Merit-based Incentive Payment System: 2019 Changes.

Adv Skin Wound Care 2019 Feb;32(2):94-96

Cathy Thomas Hess, BSN, RN, CWCN, is Vice President and Chief Clinical Officer for Wound Care, Net Health. Ms Hess presides over Net Health 360 WoundExpert Professional Services, which offers products and solutions to optimize process and workflows. Address correspondence to Ms Hess via e-mail:

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http://dx.doi.org/10.1097/01.ASW.0000552866.40487.07DOI Listing
February 2019

Implementing a Chronic Wound Care Workshop for Internal Medicine Residents.

Adv Skin Wound Care 2019 Feb;32(2):85-87

Elizabeth Foy White-Chu, MD, CWSP, AGSF, is Assistant Professor of Medicine, Oregon Health and Science University; Tri Le, MD, is Geriatrician, Adena Medical Group; and Renee Cordrey, PhD(c), MSPT, MPH, PT, CWS, is Rehabilitation Director, HealthPRO Heritage at Home. Acknowledgments: The authors thank the Scholarship and Innovation Petal of the Educational Consortium at Oregon Health and Science University for providing support for this article. The authors have disclosed no financial relationships related to this article. Submitted May 8, 2018; accepted July 11, 2018.

Objective: To determine the feasibility of a piloted wound care curriculum within a busy internal medicine (IM) curriculum.

Methods: This prospective pilot study was conducted with 89 IM residents at an academic teaching hospital. The residents were provided a 90-minute workshop in chronic wound care. Read More

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http://dx.doi.org/10.1097/01.ASW.0000549609.21974.6fDOI Listing
February 2019

Martorell's Ulcer Successfully Treated by Wireless Microcurrent Stimulation Technology.

Adv Skin Wound Care 2019 Feb;32(2):81-84

Peter G. Wirsing, MD, is Head of the Wound Center, Ostalb-Klinikum Aalen, Germany. Maria Konstantakaki is a researcher and Konstantinos A. Poulas, PhD, is Associate Professor in the Department of Pharmacy, University of Patras, Greece. The authors have disclosed no financial relationships related to this article. Submitted March 31, 2018; accepted in revised form June 22, 2018.

Martorell's ulcers are hard-to-heal leg ulcers typically accompanied by a significant elevation of blood pressure and severe pain. This case study examines the use of an innovative technology, wireless microcurrent stimulation, for the healing of a Martorell's ulcer. Using wireless microcurrent stimulation, study authors managed to reduce the size of a large Martorell's ulcer by 90% within 8 weeks. Read More

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http://dx.doi.org/10.1097/01.ASW.0000550590.31545.67DOI Listing
February 2019

Managing Ulcers Associated with Pyoderma Gangrenosum with a Urinary Bladder Matrix and Negative-Pressure Wound Therapy.

Adv Skin Wound Care 2019 Feb;32(2):70-76

At the Wake Forest Baptist Medical University in Winston-Salem, North Carolina, Claire Sanger Dillingham, DO, is Associate Professor, Plastic and Reconstructive Surgery Department; and Joseph Jorizzo, MD, is Professor, Dermatology Department. The authors have disclosed no financial relationships related to this article. Submitted March 21, 2018; accepted in revised form June 12, 2018.

Pyoderma gangrenosum (PG) is a rare disease that presents as painful ulcerations with inflammation and undermining at the borders. The ulcers can occur anywhere on the body but are most commonly seen on the lower extremities. The etiology of PG is unknown, and there are no definitive diagnostic criteria; PG is a diagnosis of exclusion, which can present serious delays in treatment. Read More

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http://dx.doi.org/10.1097/01.ASW.0000546120.32681.bcDOI Listing
February 2019

Diagnosis and Management of Cutaneous Psoriasis: A Review.

Adv Skin Wound Care 2019 Feb;32(2):58-69

Alisa Brandon, MSc • Medical Student • University of Toronto • Toronto, Ontario, Canada Asfandyar Mufti, MD • Dermatology Resident • University of Toronto • Toronto, Ontario, Canada R. Gary Sibbald, DSc (Hons), MD, MEd, BSc, FRCPC (Med Derm), ABIM, FAAD, MAPWCA • Professor • Medicine and Public Health • University of Toronto • Toronto, Ontario, Canada • Director • International Interprofessional Wound Care Course and Masters of Science in Community Health (Prevention and Wound Care) • Dalla Lana Faculty of Public Health • University of Toronto • Past President • World Union of Wound Healing Societies • Editor-in-Chief • Advances in Skin and Wound Care • Philadelphia, Pennsylvania.

General Purpose: To provide information about the diagnosis and management of cutaneous psoriasis.

Target Audience: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care.

Learning Objectives/outcomes: After completing this continuing education activity, the provider should be better able to: ABSTRACT: Psoriasis is a chronic inflammatory disease that is characterized by plaque, inverse, guttate, pustular, and erythrodermic variants. Read More

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http://dx.doi.org/10.1097/01.ASW.0000550592.08674.43DOI Listing
February 2019

Fiction or Fact: Reimbursement for Cellular and/or Tissue-Based Products for Skin Wounds.

Adv Skin Wound Care 2019 Feb;32(2):55-57

Kathleen D. Schaum, MS, is President and Founder of Kathleen D. Schaum & Associates, Inc, Lake Worth, Florida. Ms Schaum can be reached for questions and consultations by calling 561-964-2470 or through her email address: Submit your questions for Payment Strategies by mail to Kathleen D. Schaum, MS, 6491 Rock Creek Dr, Lake Worth, FL 33467.

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http://dx.doi.org/10.1097/01.ASW.0000550738.26041.c5DOI Listing
February 2019

Online "Versus" Print: No More an Either/Or.

Adv Skin Wound Care 2019 Feb;32(2):53

Elizabeth A. Ayello, PhD, RN, CWON, ETN, MAPWCA, FAAN, is the co-Editor-in-Chief of Advances in Skin & Wound Care; Faculty, Excelsior College School of Nursing, Albany, New York; and President, World Council of Enterostomal Therapists, President, Ayello Harris & Associates, Inc, Copake, New York, President (1999) National Pressure Ulcer Advisory Panel. R. Gary Sibbald, MD, DSc (Hons), MEd, BSc, FRCPC (Med Derm), FAAD, MAPWCA, JM, is the co-Editor-in-Chief of Advances in Skin & Wound Care; Professor, Medicine and Public Health, University of Toronto, Toronto, Ontario, Canada; Director, International Interprofessional Wound Care Course & Masters of Science in Community Health (Prevention & Wound Care), Dalla Lana Faculty of Public Health, University of Toronto; and President (2008-2012), World Union of Wound Healing Societies.

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http://dx.doi.org/10.1097/01.ASW.0000552821.84096.6bDOI Listing
February 2019

Ultrasound-guided placement of a midline catheter in a patient with extensive postburn contractures: A Case report.

Medicine (Baltimore) 2019 Jan;98(3):e14208

Big Data Center for Integrative Analysis, Gunma University Initiative for Advanced Research, Maebashi, Gunma, Japan.

Rationale: Obtaining venous access in a patient with extensive postburn scar contractures is a challenge.

Patient Concerns: A 39-year-old woman suffered a burn 2 years previously with a total body surface area burn of 93%, and a burn index of 85. Reconstructive surgery was previously performed 39 times. Read More

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http://dx.doi.org/10.1097/MD.0000000000014208DOI Listing
January 2019

Relaxed skin tension line-oriented keystone-designed perforator island flaps considering the facial aesthetic unit concept for the coverage of small to moderate facial defects.

Medicine (Baltimore) 2019 Jan;98(3):e14167

Department of Plastic and Reconstructive Surgery, Konyang University Hospital, University of Konyang College of Medicine, Myunggok Medical Research Center.

A variety of reconstructive options including skin grafts, loco-regional flaps, and free flaps exist for the coverage of facial defects. Each technique has advantages and disadvantages. In this study, we present our experience with relaxed skin tension line (RSTL)-oriented, keystone-designed perforator island flap (KDPIF) reconstructions, in consideration of the facial aesthetic unit concept for coverage of small to moderate facial defects. Read More

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http://dx.doi.org/10.1097/MD.0000000000014167DOI Listing
January 2019

Cutaneous vasculitis in a patient with ankylosing spondylitis: A case report.

Authors:
Chao Ye Wenyuan Li

Medicine (Baltimore) 2019 Jan;98(3):e14121

Rationale: Cutaneous vasculitis is usually found in patients with rheumatoid arthritis (RA) as an extra-articular manifestation, but rare in patients with ankylosing spondylitis (AS). In this case, we describe an AS patient who developed large skin lesions, of which the histological findings were consistent with cutaneous vasculitis.

Patient Concerns: A 22-year-old male who was diagnosed as HLA-27 positive AS for 5 years. Read More

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http://dx.doi.org/10.1097/MD.0000000000014121DOI Listing
January 2019

Potency of descending pain modulatory system is linked with peripheral sensory dysfunction in fibromyalgia: An exploratory study.

Medicine (Baltimore) 2019 Jan;98(3):e13477

Post-Graduate Program in Medical Sciences, Medical Engineering Service.

Fibromyalgia (FM) is characterized by chronic widespread pain whose pathophysiological mechanism is related to central and peripheral nervous system dysfunction. Neuropathy of small nerve fibers has been implicated due to related pain descriptors, psychophysical pain, and neurophysiological testing, as well as skin biopsy studies. Nevertheless, this alteration alone has not been previously associated to the dysfunction in the descending pain modulatory system (DPMS) that is observed in FM. Read More

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http://dx.doi.org/10.1097/MD.0000000000013477DOI Listing
January 2019

The authors reply.

Crit Care Med 2019 Feb;47(2):e162-e163

School of Nursing and Midwifery, Menzies Health Institute Queensland, Griffith University, QLD, Australia; Department of Public Health, College of Health Sciences, Qatar University, Doha, Qatar; Menzies Health Institute Queensland, Griffith University, QLD, Australia; Intensive Care Services, Royal Brisbane and Women's Hospital and School of Nursing, Queensland University of Technology, Brisbane, QLD, Australia, and Institute for Skin Integrity and Infection Prevention, University of Huddersfield, Huddersfield, United Kingdom; Department of Internal Medicine, Ghent University, Ghent, Belgium, and Burns, Trauma and Critical Care Research Centre, University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia; Menzies Health Institute Queensland, Griffith University, QLD, Australia; Department of Medical-Surgical Nursing, School of Nursing, University of Saõ Paulo, Saõ Paulo, Brazil; School of Nursing and Midwifery, Menzies Health Institute Queensland, Griffith University, QLD, Australia.

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http://dx.doi.org/10.1097/CCM.0000000000003565DOI Listing
February 2019

Granuloma With an Underlying Lymphoma: A Diagnostic Challenge and a Wider Histologic Spectrum Including Adult T-Cell Leukemia/Lymphoma.

Appl Immunohistochem Mol Morphol 2019 Jan 15. Epub 2019 Jan 15.

Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei.

Granulomatous reaction is not uncommon in histopathology, with various etiologies in different organs and geographic regions. Lymphoma is one of the underlying causes of granuloma; and sometimes the neoplastic cells may be masked by the granulomatous reaction. In this report, we present our experience with 7 lymphoma cases of various histologic types with coexisting granuloma to show the diagnostic challenges. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000731DOI Listing
January 2019

Multifunctional Screen-Printed TiO2 Nanoparticles Tuned by Laser Irradiation for Flexible and Scalable UV Detector and Room Temperature Ethanol Sensor.

ACS Appl Mater Interfaces 2019 Jan 17. Epub 2019 Jan 17.

Recently, multifunctional devices printed on flexible substrates, with multisensing capability, have found new demand in the practical fields of application such as wearable electronics, soft robotics, interactive interfaces and electronic skin design, revealing the vital importance of precise control of the fundamental properties of metal oxide nanomaterials. In this paper, a novel low-cost and scalable processing strategy is proposed to fabricate all-printed multisensing devices with UV and gas sensing capabilities. Undertaken approach is based on the hierarchical combination of screen-printing process and laser irradiation post-treatment. Read More

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http://dx.doi.org/10.1021/acsami.8b19976DOI Listing
January 2019

Clinical and epidemiological impact of varicella infection in children prior to the introduction of the varicella vaccine in the national immunization schedule of Argentina.

Arch Argent Pediatr 2019 Feb;117(1):12-18

Servicio de Infectología Pediátrica.

Introduction: In Argentina, an estimated 400 000 varicella cases occur annually. Given the under-recording of existing cases, the actual burden of disease is unknown.

Objective: To assess the burden of varicella before the introduction of the varicella vaccine in the national immunization schedule. Read More

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http://dx.doi.org/10.5546/aap.2018.eng.12DOI Listing
February 2019

Epithelial expression of the hormone leptin by bovine skin.

Eur J Histochem 2019 Jan 17;63(1). Epub 2019 Jan 17.

University of Perugia, Department of Veterinary Medicine.

Leptin (Lep) stimulates keratinocytes to proliferate, intervenes in the wound healing and participates to hair follicle morphogenesis and cycle. While it is secreted by skin structures including epidermis and hair follicles, intradermal adipose tissue also seems to have a role in Lep secretion and accordingly in the control of hair follicle growth in mice and humans. Lep was investigated in the skin of humans and laboratory animals but there are not data regarding bovine species. Read More

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http://dx.doi.org/10.4081/ejh.2019.2993DOI Listing
January 2019

Pictorial review of Morel-Lavallée lesions.

J Med Imaging Radiat Oncol 2019 Jan 16. Epub 2019 Jan 16.

Women and Children Hospital Adelaide, Benson Radiology, Adelaide, South Australia, Australia.

A Morel-Lavallée lesion is a post-traumatic soft tissue degloving injury which presents as a haemolymphatic mass or collection. Morel-Lavallée lesions are the result of direct trauma or shearing forces abruptly separating skin and subcutaneous tissue from underlying fascia causing disruption of perforating vessels and nerves, creating a potential space that may fill with blood, lymph and debris forming a collection. Morel-Lavallée lesions usually occur adjacent to osseous protuberances, most commonly along the greater trochanter. Read More

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http://dx.doi.org/10.1111/1754-9485.12854DOI Listing
January 2019
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