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J Clin Pathol 2022 Jun 28. Epub 2022 Jun 28.

Plastic Surgery, University Hospital of North Staffordshire NHS Trust, Stoke-on-Trent, UK.

Marker sutures are often used for excised cutaneous lesions to aid histological analysis, however, there are no current guidelines to facilitate this in practice. The authors hypothesised that a lack of guidelines causes a variation in clinical practice and confusion of meaning between plastic surgeons and pathologists. This questionnaire-based study confirms the authors' hypothesis and highlights a discrepancy both between surgeons and in individual surgical practice. Read More

J Reconstr Microsurg 2022 Jun 28. Epub 2022 Jun 28.

Harvard Medical School, Boston, United States.

Background For 50 years, static cold storage (SCS) has been the gold standard for solid organ preservation in transplantation. Although logistically convenient, this preservation method presents important constraints in terms of duration and cold ischemia-induced lesions. We aimed to develop a machine perfusion (MP) protocol for the recovery of vascularized composite allografts (VCA) after static cold preservation and determine its effects in a rat limb transplantation model. Read More

Clin Immunol 2022 Jun 25:109069. Epub 2022 Jun 25.

College of Food Science and Technology, Yunnan Agricultural University, Heilong Tan, Kunming 650201, Yunnan, China. Electronic address:

Wasp pupa protein has triggered allergies in certain consumers. In this study, we investigated the allergenicity of alcohol-soluble wasp pupa protein (ACWP) and its effect on the gut microbiota of mice in vivo. It was found that ACWP caused skin erythema and diarrhea in mice, the up-regulation of HIS, IgE, IL-4, IL-22, and IL-17A, and down-regulation of IgG2a, IgA, and IL-2 in serum. Read More

Toxicol In Vitro 2022 Jun 25:105425. Epub 2022 Jun 25.

National Institute of Metrology, Quality and Technology (Inmetro), Directorate of Scientific Metrology applied to Life Sciences, Av. Nossa Senhora das Graças, 50, Xerém, CEP 25250-020 Duque de Caxias, RJ, Brazil.

Usually, if percutaneous absorption tests are conducted in accordance with OECD Guideline 428, in vitro determination is accepted by mainly regulatory agencies. In this paper, we focus on the lack of comparability of the results regarding the permeation parameter/flow rate, although it is widely discussed in the literature. This work sought to evaluate the absorption of caffeine using Franz-type diffusion cell with porcine ear skin samples, varying the storage duration and the way to handle them. Read More

Matrix Biol 2022 Jun 25. Epub 2022 Jun 25.

Unit of Molecular Oncology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy.

Alterations in extracellular matrix (ECM) components that modulate inflammatory cell behavior have been shown to serve as early starters for multifactorial diseases such as fibrosis and cancer. Here, we demonstrated that loss of the ECM glycoprotein EMILIN-1 alters the inflammatory context in skin during IMQ-induced psoriasis, a disease characterized by a prominent inflammatory infiltrate and alteration of vessels that appear dilated and tortuous. Abrogation of EMILIN-1 expression or expression of the EMILIN-1 mutant E933A impairs macrophage polarization and leads to imbalanced tissue homeostasis. Read More

Int J Psychophysiol 2022 Jun 25. Epub 2022 Jun 25.

Department of Management, Aarhus University, Denmark.

This paper provides an accessible review of the biological and psychological evidence to guide new and experienced researchers in the study of emotional piloerection in humans. A limited number of studies have attempted to examine the physiological and emotional correlates of piloerection in humans. However, no review has attempted to collate this evidence to guide the field as it moves forward. Read More

Hum Pathol 2022 Jun 25. Epub 2022 Jun 25.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA; Department of Dermatology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Autoimmune bullous dermatoses are characterized by the presence of tissue-bound and often circulating pathogenic autoantibodies targeting structural components of the skin and/or mucous membranes. The diagnostic workup for this heterogeneous group of disorders consists of a multi-step process, of which the light microscopic examination is a crucial component. This review is organized following a classification scheme that is based on two main histopathologic features, namely level of intraepithelial split and composition of the inflammatory infiltrate. Read More

Gac Med Mex 2022 ;158(2):104-109

Neuroimmunoendocrinology Laboratory, Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez".

Introduction: Fibromyalgia (FM) is a non-degenerative syndrome characterized by generalized, chronic musculoskeletal pain, as well as mood, memory and sleep disorders.

Objective: To search for serum anti-neural antibodies (ANeuA) in patients with FM (FMP) in order to rule out autoimmune etiology.

Methods: The Fibromyalgia Impact Questionnaire (FIQ) and Beck's depression inventory (BDI) were applied. Read More

Mol Pharm 2022 Jun 28. Epub 2022 Jun 28.

Biopharmaceutics Research Institute, Rhodes University, Grahamstown 6139, South Africa.

The widespread use of topical corticosteroids (TCs) in dermatotherapy requires a consideration of their potency and benefit/risk ratios. Although there are a variety of topical corticosteroid products (TCPs) available on the market and their potencies are ranked using different classification systems, to our knowledge, no classification system to rank the inherent potencies of TC active pharmaceutical ingredients (APIs) currently exists. Most of the published classification systems for TCPs are based on randomized clinical comparative studies and/or vasoconstrictor assay (VCA) data. Read More

Pediatr Infect Dis J 2022 Jun 27. Epub 2022 Jun 27.

Pediatric Infectious Diseases Department, Hospital Universitario La Paz, Madrid, Spain.

Background: Osteoarticular infections (OAIs) are typically treated initially with intravenous antibiotics. The objective of this study was to evaluate whether an exclusive oral treatment in selected children may be appropriate.

Methods: The Spanish Network of Osteoarticular Infections is a nationwide multicenter registry comprising 37 hospitals in Spain. Read More

Pediatr Infect Dis J 2022 Jun 24. Epub 2022 Jun 24.

Department of Microbiology, Hyogo College of Medicine, Nishinomiya, Japan.

Background: Pityriasis rosea Gibert (PRG) has features similar to those of common infectious childhood diseases, suggesting a viral cause, but no agent has been identified to date. We describe 4 children with PRG and 2 with recurrent varicella who were studied using photochronography, virology and immunology.

Methods: The 6 patients with skin rashes visited our pediatric clinic from April 2012 to May 2016. Read More

Asian Pac J Cancer Prev 2022 Jun 1;23(6):1927-1933. Epub 2022 Jun 1.

National Nutrition and Food Technology Research Institute and Faculty of Nutrition Science and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background And Objective: Sunlight exposure, the main source of endogenous vitamin D synthesis, may increase the risk of non-melanoma skin cancers (NMSC) development. Vitamin D receptor (VDR) polymorphisms are associated with various malignancies. This study aimed to examine the associations between vitamin D status and VDR FokI polymorphisms in Iranian subjects with NMSC. Read More

J Low Genit Tract Dis 2022 Jul 21;26(3):229-244. Epub 2022 Jun 21.

Division of Gynaecological Oncology, Department of Obstetrics and Gynaecology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Abstract: The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) developed consensus statements on pre-invasive vulvar lesions in order to improve the quality of care for patients with vulvar squamous intraepithelial neoplasia, vulvar Paget disease in situ, and melanoma in situ. For differentiated vulvar intraepithelial neoplasia (dVIN), an excisional procedure must always be adopted. For vulvar high-grade squamous intraepithelial lesion (VHSIL), both excisional procedures and ablative ones can be used. Read More

J Cosmet Dermatol 2022 Jun 28. Epub 2022 Jun 28.

Division of Dermatology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Introduction: During the ongoing COVID-19 outbreak, face mask use has increased and became a part of our daily lives. While wearing, prolonged contact time and microenvironmental change profoundly lead to an acne flare-up, defined as "maskne".

Aims: We aimed to assess the efficacy and safety of snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glaba root extract combination serum (SCGS) in treating the maskne. Read More

J Dermatolog Treat 2022 Jun 28:1-33. Epub 2022 Jun 28.

Pfizer Inc., New York, NY, USA.

Background: Abrocitinib, a once-daily, oral Janus kinase 1 selective inhibitor, was shown to be an effective treatment for moderate-to-severe atopic dermatitis in phase 2b/3 monotherapy trials.

Methods: These analyses included data for Investigator's Global Assessment responder (clear [0] or almost clear [1] with ≥2-grade improvement) and nonresponder patients with moderate-to-severe atopic dermatitis who received abrocitinib (200 mg or 100 mg) or placebo in three abrocitinib monotherapy trials (phase 2b, NCT02780167; two phase 3, NCT03349060/JADE MONO-1 and NCT03575871/JADE MONO-2). Outcomes measuring skin clearance, itch, and quality of life were evaluated. Read More

Lymphat Res Biol 2022 Jun 28. Epub 2022 Jun 28.

Department of Rehabilitation Medicine, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.

A previous study reported a new ultrasonography (US) measurement technique to evaluate the cross-sectional area (ΔCSA) of lymphedema in the upper extremity. This ΔCSA correlated well with parameters, such as the circumference, volumetry, and bioimpedance analysis (BIA) in healthy people and upper extremity lymphedema patients. This study examined whether a US measurement technique is clinically useful in patients with lymphedema in the lower extremity. Read More

Drugs 2022 Jun 28. Epub 2022 Jun 28.

Division of Family Medicine, Department of Internal Medicine, Lebanese American University School of Medicine, Beirut, Lebanon.

Human monkeypox is a zoonotic orthopoxvirus with presentation similar to smallpox. Monkeypox is transmitted incidentally to humans when they encounter infected animals. Reports have shown that the virus can also be transmitted through direct contact (sexual or skin-to-skin), respiratory droplets, and via fomites such as towels and bedding. Read More

Drug Deliv Transl Res 2022 Jun 28. Epub 2022 Jun 28.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 North Pine Street, Baltimore, MD, 21201, USA.

Due to high variability during clinical pharmacokinetic (PK) evaluation, the prediction of in vivo exposure from in vitro absorption testing of topical semisolid and liquid dermal products has historically proven difficult. Since absorption from unoccluded formulations can be influenced by environmental factors such as temperature and humidity, maximal effort must be placed on the harmonization of experimental parameters between in vitro and in vivo testing conditions to establish accurate in vitro/in vivo correlations (IVIVC). Using four different sunscreen formulations as a model, we performed in vitro permeation testing (IVPT) studies with excised human skin and maintained strict harmonization techniques to control application time, occlusion, temperature, and humidity during in vivo human serum PK evaluation. Read More

Cell Tissue Bank 2022 Jun 28. Epub 2022 Jun 28.

Center for Musculoskeletal Surgery, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.

In Germany, bone allografts are widely used and their application in clinics has increased over the years. Successful use of allografts depends on many factors such as the procurement, processing, sterilization and the surgeon's surgical experience. Tissue banks have provided safe and sterile allografts for decades ranging from hard to soft tissue. Read More

Arch Toxicol 2022 Jun 28. Epub 2022 Jun 28.

Department of Occupational and Environmental Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan.

Occupational exposure to trichloroethylene (TCE) causes a systemic skin disorder with hepatitis known as TCE hypersensitivity syndrome (TCE-HS). Human Leukocyte Antigen (HLA)-B*13:01 is its susceptibility factor; however, the immunological pathogenesis of TCE-HS remains unknown. We herein examined the hypothesis that autoantibodies to CYP2E1 are primarily involved in TCE-HS. Read More

Clin Cancer Res 2022 Jun 28:OF1-OF7. Epub 2022 Jun 28.

Department of Medical Oncology, Kindai University Faculty of Medicine, Onohigashi, Osakasayama, Japan.

Purpose: To explore the efficacy of retreatment with immune checkpoint inhibitors (ICI) in patients with advanced non-small cell lung cancer (NSCLC) who responded to prior ICI and had adequate ICI-free interval.

Patients And Methods: Patients with advanced NSCLC who had achieved complete response (CR), partial response (PR), or stable disease for ≥6 months with prior ICI therapy preceding progression were prospectively enrolled. All patients should have had ICI-free interval ≥60 days before registration. Read More

Arthritis Rheumatol 2022 Jun 28. Epub 2022 Jun 28.

Division of Rheumatology, Department of Internal Medicine.

Arthritis Rheumatol 2022 Jun 28. Epub 2022 Jun 28.

Feinberg School of Medicine, Scleroderma Program, Northwestern University, Chicago, IL, USA.

Objective: Systemic sclerosis (SSc) is characterized by immune activation, vasculopathy, and unresolving fibrosis in the skin, lungs, and other organs. We performed RNA-Seq analysis on skin biopsies and peripheral blood mononuclear cells (PBMCs) from SSc patients and controls to better understand SSc pathogenesis.

Methods: We analyzed these data to 1) test for case-control differences, and 2) identify genes whose expression levels correlate with SSc severity as measured by local skin score, modified Rodnan skin score (MRSS), forced vital capacity (FVC), or diffusion capacity for carbon monoxide (DLCO). Read More

J Fish Dis 2022 Jun 28. Epub 2022 Jun 28.

Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.

Chinese perch (Siniperca chuatsi), an important fish for the aquaculture industry of China, is often affected by viral diseases. A stable and sensitive cell line can play an important role in virus identification and isolation, functional gene identification, virus pathogenic mechanism and antiviral immunity study. In the present study, a new cell line (S. Read More

J Dtsch Dermatol Ges 2022 Jun 28. Epub 2022 Jun 28.

Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University, Jinan, Shandong, China.

J Vet Pharmacol Ther 2022 Jun 28. Epub 2022 Jun 28.

Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.

Several different tick species are known to infest horses. Aside from causing serious health and welfare issues, including anaemia, ill thrift, and immunosuppression, ticks can transmit a variety of important, sometimes zoonotic, pathogens. The successful prevention and treatment of tick infestations have been described, but the information is scarce and, in many instances, anecdotal. Read More

J Craniofac Surg 2022 Jun 28. Epub 2022 Jun 28.

Department of Plastic and Reconstructive Surgery, Xijing Hospital of Forth Military Medical University, Xi'an, China.

Objectives: Auricular reconstruction is a great challenge for surgeons to achieve good aesthetic outcomes when adjacent tissues were burned. Compared with pedicle flap therapies, there are some advantages of pre-expanded free flaps for ear rebuilding, such as thinner layer tissues for aesthetic requirements of delicate auricular structures and less donor site deformity. In this study, the authors introduced 6 sequential surgical procedures for total auricular reconstruction with severe ipsilateral facial scar. Read More

J Biomed Mater Res A 2022 Jun 28. Epub 2022 Jun 28.

Department of Clinical Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.

Graphene-based nanocomposites have recently attracted increasing attention in tissue engineering because of their extraordinary features. These biocompatible substances, in the presence of an apt microenvironment, can stimulate and sustain the growth and differentiation of stem cells into different lineages. This review discusses the characteristics of graphene and its derivatives, such as their excellent electrical signal transduction, carrier mobility, outstanding mechanical strength with improving surface characteristics, self-lubrication, antiwear properties, enormous specific surface area, and ease of functional group modification. Read More

ACS Appl Mater Interfaces 2022 Jun 28. Epub 2022 Jun 28.

Shaanxi Key Laboratory of Photoelectric Functional Materials and Devices, School of Materials and Chemical Engineering, Xi'an Technological University, Xi'an710021, Shaanxi, P. R. China.

Electronic skins (e-skins) are increasingly investigated and applied in wearable devices, but the robustness and convenient production of traditional e-skins are restricted. In this work, electrospun sandwich-structured elastic films (ESEFs) are developed and utilized as capacitive e-skins. The ESEFs consist of two nanocomposite mats as the electrode layers and a sandwiched thermoplastic polyurethane (TPU) mat as the dielectric layer. Read More

Br J Dermatol 2022 Jun 28. Epub 2022 Jun 28.

Pathology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS Reggio Emilia, Viale Risorgimento 80, 42123, Reggio Emilia, Italy.