884,981 results match your criteria Skin Cancer - Melanoma* Otolaryngology and Facial Plastic Surgery

Phosphorylated alpha-synuclein in Iba1-positive macrophages in the skin of patients with Parkinson's disease.

Ann Clin Transl Neurol 2022 Jun 24. Epub 2022 Jun 24.

Department of Neurology, National Hospital Organization Sendai Nishitaga Hospital, Sendai, Japan.

Background: Increasing evidence suggests that alpha-synuclein (αSyn) accumulation in cholinergic and adrenergic fibers in the skin is a useful biomarker to diagnose idiopathic Parkinson's disease (IPD). It has been widely reported that phosphorylated αSyn (p-αSyn) deposits in autonomic fibers in IPD are a biomarker in the skin, but other tissue localizations have not been fully investigated.

Objective: It has been previously suggested that αSyn aggregates activate peripheral macrophages and that peripheral macrophages ingest pathological αsyn aggregates in aged rats or IPD patients. Read More

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Rare cause of diffuse alveolar haemorrhage and subconjunctival haemorrhage rescued by extracorporeal membrane oxygenation and rituximab.

BMJ Case Rep 2022 Jun 24;15(6). Epub 2022 Jun 24.

Department of Rheumatology, Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

A previously healthy man in his 20s presented with acute respiratory distress syndrome and subconjunctival haemorrhage. Imaging was indicative of pervasive pulmonary haemorrhage. There was no evidence of renal involvement. Read More

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Cutaneous Pharmacokinetic Approaches to Compare Bioavailability and/or Bioequivalence for Topical Drug Products.

Dermatol Clin 2022 Jul;40(3):319-332

10716 SE Forest View Lane, Happy Valley, OR 97086, USA.

The evaluation of bioequivalence (BE) involves comparing the test product to its reference product in a study whose fundamental scientific principles allow inferring of the clinical performance of the products. Several test methods have been discussed and developed to evaluate topical bioavailability (BA) and BE. Pharmacokinetics-based approaches characterize the rate and extent to which an active ingredient becomes available at or near its site of action in the skin. Read More

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How Does the Food and Drug Administration Approve Topical Generic Drugs Applied to the Skin?

Dermatol Clin 2022 Jul 1;40(3):279-287. Epub 2022 Jun 1.

Office of Research and Standards, Office of Generic Drugs, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.

Approved generic drugs are therapeutically equivalent to a preidentified brand name product and are expected to have the same clinical effect and safety profile when administered to patients under conditions specified in the labeling. Availability of generic topical dermatologic drugs is expected to enhance patient access to such widely used drug products. Assessment of equivalence for a prospective generic product involves a systematic and rigorous comparative evaluation to ensure there is no significant difference in the rate and extent to which the active ingredients become available at the site of action for the prospective generic and corresponding brand name product. Read More

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Cardiovascular and metabolic changes in Brazilian truck drivers.

J Vasc Nurs 2022 Jun 23;40(2):112-116. Epub 2022 May 23.

Faculdade de Medicina, Universidade Federal de Uberlândia, Campus Umuarama - Bloco 2U, Brazil. Electronic address:

Objective: To identify the relationship between the Ankle Brachial Index (ABI) and the presence of cardio-metabolic diseases, alcohol, and tobacco abuse among truck drivers.

Methods: This is a cross-sectional study with a quantitative approach carried out with 235 truck drivers. Demographic, professional, clinical, alcohol, and tobacco abuse data were collected through interviews. Read More

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Potential shared therapeutic and hepatotoxic mechanisms of Tripterygium wilfordii polyglycosides treating three kinds of autoimmune skin diseases by regulating IL-17 signaling pathway and Th17 cell differentiation.

J Ethnopharmacol 2022 Jun 21:115496. Epub 2022 Jun 21.

Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, China. Electronic address:

Ethnopharmacological Relevance: Tripterygium wilfordii polyglycosides (TWP) are extracted from Tripterygium wilfordii Hook. f., which has the significant effects of anti-inflammation and immunosuppression and has been widely used to treat autoimmune diseases in traditional Chinese medicine. Read More

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A comic-based body image intervention for adolescents in semi-rural Indian schools: Study protocol for a randomized controlled trial.

Body Image 2022 Jun 21;42:183-196. Epub 2022 Jun 21.

Centre for Appearance Research, University of the West of England, UK.

Adolescents in India experience body dissatisfaction, however, empirically supported interventions are lacking. This paper describes the protocol for the development, acceptability testing, and cluster randomized controlled trial (RCT) of a six-session comic-based intervention, which aims to improve body image and related outcomes among adolescents in semi-rural Indian schools. If found to be acceptable and effective, UNICEF will disseminate the intervention across schools in eight states of India. Read More

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Systematic Review of Patient Safety and Quality Improvement Initiatives in Breast Reconstruction.

Ann Plast Surg 2022 Jul 24;89(1):121-136. Epub 2022 Jan 24.

Division of Plastic Surgery, Dalhousie University, Halifax, Nova Scotia, Canada.

Background: Improving patient care and safety requires high-quality evidence. The objective of this study was to systematically review the existing evidence for patient safety (PS) and quality improvement initiatives in breast reconstruction.

Methods: A systematic review of the published plastic surgery literature was undertaken using a computerized search and following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Read More

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Benign Neonatal Hemangiomatosis.

Adv Neonatal Care 2022 Mar 29. Epub 2022 Mar 29.

Center for Clinical Studies, Webster, Texas (Dr Miller); Mercer University School of Medicine, Macon, Georgia (Drs Miller, Gordon, Peterson, and Cohen); Department of Pediatrics, Beverly Knight Olson Children's Hospital, Navicent Health, Macon, Georgia (Drs Gordon and Peterson); Skin Care Physicians of Georgia, Macon, Georgia (Dr Cohen); and Department of Pediatrics, Spartanburg Regional Healthcare System, Spartanburg, South Carolina (Dr Bowe).

Background: Benign neonatal hemangiomatosis (BNH) is a rare, self-limiting subtype of infantile hemangiomas (IHs), in which infants with multiple cutaneous hemangiomas lack visceral involvement. Other subtypes of IHs exist that may mimic BNH and can be life-threatening depending on hemangioma location and size.

Clinical Findings: At birth, a 295/7-week preterm female presented with several pinhead-sized pink papules distributed throughout her body. Read More

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Comments on "A Simple, Rapid, Comparative Evaluation of Multiple Products for Decontamination of Actinide-contaminated Rat Skin Ex Vivo".

Health Phys 2022 Aug;123(2):154-155

Institut de Radioprotection et Sûreté Nucléaire PSE-SANTE/SESANE/LRSI 31 Avenue de la Division Leclerc 92260, Fontenay-aux-Roses, France.

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DPP-4 inhibitor linagliptin ameliorates imiquimod-induced psoriasis-like skin alterations in type 2 diabetic mice by inhibiting the MAPK/NF-κB inflammatory pathway.

Drug Dev Res 2022 Jun 24. Epub 2022 Jun 24.

Department of Endocrinology, 900 Hospital of the Joint Logistics Team, Fuzong Clinical Medical College of Fujian Medical University, Fujian, Fuzhou, China.

Studies have shown that the DPP-4 inhibitor was effective in improving skin damage in patients with psoriasis, but the exact mechanism was not known. To investigate the therapeutic effects of linagliptin in mice with type 2 diabetes mellitus (T2DM) with psoriasis and its possible therapeutic mechanisms. A total of 32 db/db mice and 16 db/m mice were randomly divided into six groups: normal group, psoriasis group, diabetes group, diabetes combined with psoriasis group, linagliptin-treated diabetes group, and linagliptin-treated diabetes combined with psoriasis group. Read More

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Human organ rejuvenation by VEGF-A: Lessons from the skin.

Sci Adv 2022 Jun 24;8(25):eabm6756. Epub 2022 Jun 24.

Skin Research Laboratory, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.

Transplanting aged human skin onto young SCID/beige mice morphologically rejuvenates the xenotransplants. This is accompanied by angiogenesis, epidermal repigmentation, and substantial improvements in key aging-associated biomarkers, including ß-galactosidase, p16, SIRT1, PGC1α, collagen 17A, and MMP1. Angiogenesis- and hypoxia-related pathways, namely, vascular endothelial growth factor A (VEGF-A) and HIF1A, are most up-regulated in rejuvenated human skin. Read More

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Personalised pose estimation from single-plane moving fluoroscope images using deep convolutional neural networks.

PLoS One 2022 24;17(6):e0270596. Epub 2022 Jun 24.

Institute for Biomechanics, ETH Zürich, Zürich, Switzerland.

Measuring joint kinematics is a key requirement for a plethora of biomechanical research and applications. While x-ray based systems avoid the soft-tissue artefacts arising in skin-based measurement systems, extracting the object's pose (translation and rotation) from the x-ray images is a time-consuming and expensive task. Based on about 106'000 annotated images of knee implants, collected over the last decade with our moving fluoroscope during activities of daily living, we trained a deep-learning model to automatically estimate the 6D poses for the femoral and tibial implant components. Read More

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White patients' physical responses to healthcare treatments are influenced by provider race and gender.

Proc Natl Acad Sci U S A 2022 Jul 27;119(27):e2007717119. Epub 2022 Jun 27.

Department of Psychology, Stanford University, Stanford, CA 94305.

The healthcare workforce in the United States is becoming increasingly diverse, gradually shifting society away from the historical overrepresentation of White men among physicians. However, given the long-standing underrepresentation of people of color and women in the medical field, patients may still associate the concept of doctors with White men and may be physiologically less responsive to treatment administered by providers from other backgrounds. To investigate this, we varied the race and gender of the provider from which White patients received identical treatment for allergic reactions and measured patients' improvement in response to this treatment, thus isolating how a provider's demographic characteristics shape physical responses to healthcare. Read More

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Resveratrol inhibits the inflammatory response and oxidative stress induced by uterine ischemia reperfusion injury by activating PI3K-AKT pathway.

PLoS One 2022 24;17(6):e0266961. Epub 2022 Jun 24.

Reproductive Medicine, Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei, China.

Uterus transplantation is a complex surgical procedure. Uterine ischemia reperfusion (I/R) injury that occurs during this process may cause a loss of function of the uterus and the failure of transplantation. Resveratrol (RSV) is a naturally occurring polyphenol found abundantly in the skin of grapes and red wine, and it has also been used as a dietary supplement in clinical practice. Read More

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Novel Complement C5 Small-interfering RNA Lipid Nanoparticle Prolongs Graft Survival in a Hypersensitized Rat Kidney Transplant Model.

Transplantation 2022 Jun 24. Epub 2022 Jun 24.

Department of Urology, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan.

Background: Prophylaxis of antibody-mediated rejection (AMR) caused by donor-specific antibodies remains challenging. Given the critical roles of complement activity in antibody-mediated graft injury, we developed a lipid nanoparticle (LNP) formulation of small-interfering RNA against complement C5 (C5 siRNA-LNP) and investigated whether C5 siRNA-LNP could downregulate the complement activity and act as an effective treatment for AMR.

Methods: Lewis recipient rats were sensitized by skin grafting from Brown Norway donor rats. Read More

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Antifreezing and Nondrying Sensors of Ionic Hydrogels with a Double-Layer Structure for Highly Sensitive Motion Monitoring.

ACS Appl Mater Interfaces 2022 Jun 24. Epub 2022 Jun 24.

School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, P. R. China.

Freezing and dehydration together with interfacial failure are capable of causing the functional reduction of hydrogels for sensing applications. Herein, we develop a multifunctional bilayer that consists of a mussel-inspired adhesive layer and a functionally ionic layer that is composed of sodium -styrene sulfonate (SSS) and an ionic liquid of [BMIM]Cl. The adhesive layer enables the strong adhesion of the bilayer to the surface of the skin. Read More

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Development and characterisation of an irradiation device for biomedical studies covering the solar spectrum with individual regulated spectral bands.

Photochem Photobiol Sci 2022 Jun 24. Epub 2022 Jun 24.

Cell Biology and Epigenetics, Department of Biology, Technical University of Darmstadt, Schnittspahnstr. 10, 64287, Darmstadt, Germany.

To understand the importance of terrestrial solar exposure on human skin, not only individual spectral components need to be considered in biomedical studies, but also the relevance of the combined action profile of the complete solar spectrum (cSS) must be established. We therefore developed a novel irradiation device that combines the emission of four individual lamps (UVB, UVA, VIS and nIR) to achieve exposure from 280 to 1400 nm with individual controllable lamps. The integrated irradiance of each spectral band is similar to the solar spectrum. Read More

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Unraveling the Pharmaceutical Benefits of Freshly Prepared Amino Acid-Based Schiff Bases Via DFT, In Silico Molecular Docking and ADMET.

J Fluoresc 2022 Jun 24. Epub 2022 Jun 24.

Department of Chemistry, Manonmaniam Sundaranar University College, Tirunelveli, 627 414, Tamil Nadu, India.

A series of amino acid-based Schiff bases have been synthesized using a facile condensation between benzil (a diketone) and amino acid in the presence of a base. The formation of Schiff base compounds has been ensured by elemental analysis, FT-IR, H-NMR, C-NMR and UV-Vis. spectra. Read More

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Anti-skin-aging effects of tissue-cultured mountain-grown ginseng and quantitative HPLC/ELSD analysis of major ginsenosides.

J Nat Med 2022 Jun 24. Epub 2022 Jun 24.

Department of Plant Science and Technology, Chung-Ang University, Anseong, 17546, Korea.

Mountain-grown ginseng has free radical scavenging activity and suppresses inflammation. We evaluated the anti-skin-aging effects of tissue-cultured mountain-grown ginseng (TG) and its major ginsenosides. The effect of three extracts of TG and ginsenosides Rg1 (1), Rf (2), Rb1 (3), Re (4), and Rd (5) on the secretion of matrix metalloproteinase-1 (MMP-1) and collagen type I alpha 1 (COLIA1) was compared with that of tumor necrosis factor-alpha (TNF-α) stimulation of human dermal fibroblasts (HDFs), as determined via enzyme-linked immunosorbent assay. Read More

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Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin.

Inflamm Res 2022 Jun 24. Epub 2022 Jun 24.

School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.

Background: Excessive exposure of the skin to UV radiation (UVR) triggers a remodeling of the immune system and leads to the photoaging state which is reminiscent of chronological aging. Over 30 years ago, it was observed that UVR induced an immunosuppressive state which inhibited skin contact hypersensitivity.

Methods: Original and review articles encompassing inflammation and immunosuppression in the photoaging and chronological aging processes were examined from major databases including PubMed, Scopus, and Google Scholar. Read More

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Predictive performance of pharmacokinetic models for target concentration-controlled infusion of cefoxitin as a prophylactic antibiotic in patients with colorectal surgery.

Clin Exp Pharmacol Physiol 2022 Jun 24. Epub 2022 Jun 24.

Division of Physical Metrology, Korea Research Institute of Standards and Science, Daejeon, South Korea.

We aimed to evaluate the predictive performance of previously constructed free (C ) and total (C ) cefoxitin pharmacokinetic models and the possibility of administering cefoxitin via the target-controlled infusion (TCI) method in clinical practice. Two external validation studies (N=31 for C model, N=30 for C model) were conducted sequentially. Cefoxitin (2 g) was dissolved in 50 mL of normal saline to give a concentration of 40 mg/mL. Read More

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Editorial: optimising hepatitis B vaccine response in inflammatory bowel disease-time to get some skin in the game.

Aliment Pharmacol Ther 2022 Jul;56(2):353-354

AW Morrow Gastroenterology and Liver Unit, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.

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Perceptions towards mask use in school children during the SARS-CoV-2 pandemic: descriptive results from the longitudinal Ciao Corona cohort study.

Swiss Med Wkly 2022 04 20;152:w30165. Epub 2022 Apr 20.

Department of Epidemiology, Epidemiology, Biostatistics and Prevention Institute (EBPI), University of Zurich, Switzerland.

Background: Mask wearing contributes to the reduction of transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In Switzerland, compulsory use of masks was introduced in indoor public spaces and later in schools. This study explored perceptions of the usefulness of masks in school and public in a cohort of children and adolescents in the canton of Zurich, Switzerland, in January to May 2021. Read More

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Exiting the Anthropocene: Achieving Personal and Planetary Health in the 21 Century.

Allergy 2022 Jun 24. Epub 2022 Jun 24.

NOVA Institute for Health, 1407 Fleet Street, Baltimore, MD 21231, USA.

Planetary health provides a perspective of ecological interdependence that connects the health and vitality of individuals, communities, and Earth's natural systems. It includes the social, political, and economic ecosystems that influence both individuals and whole societies. In an era of interconnected grand challenges threatening health of all systems at all scales, planetary health provides a framework for cross-sectoral collaboration and unified systems approaches to solutions. Read More

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Central sensitisation pain and autonomic deficiencies in fibromyalgia.

Clin Exp Rheumatol 2022 Jun 23;40(6):1202-1209. Epub 2022 Jun 23.

Department of Psychology, University of Jaén, Spain.

Objectives: Fibromyalgia (FM) is associated with central pain sensitisation, autonomic alterations and neuropathy in small nerve fibres. This study aimed to analyse the association between tonic sweating and central pain sensitisation in FM.

Methods: Fifty-eight FM patients and thirty healthy women were assessed in terms of slowly repeated evoked pain (SREP), as a measure of central sensitisation. Read More

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Distinct interactors define the p63 transcriptional signature in epithelial development or cancer.

Biochem J 2022 Jun;479(12):1375-1392

Department of Experimental Medicine, TOR, University of Rome 'Tor Vergata', Rome, Italy.

The TP63 is an indispensable transcription factor for development and homeostasis of epithelia and its derived glandular tissue. It is also involved in female germline cell quality control, muscle and thymus development. It is expressed as multiple isoforms transcribed by two independent promoters, in addition to alternative splicing occurring at the mRNA 3'-UTR. Read More

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