843,503 results match your criteria Skin Cancer - Basal Cell Carcinoma* Otolaryngology and Facial Plastic Surgery

Dermatomyositis: Patterns of MRI findings in muscles, fascia and skin of pelvis and thigh.

Eur J Radiol 2021 Jun 6;141:109812. Epub 2021 Jun 6.

Department of Radiodiagnosis, Post Graduate Institute of Medical Education & Research, Chandigarh, 160012, India.

Purpose: This review discusses characteristic, subtle, and florid changes in muscle, fascia, skin, and subcutaneous tissue of the lower limbs in MR imaging in patients with dermatomyositis.

Material And Methods: This review is based on the analysis of 43 patients with dermatomyositis who were imaged from January 2014 to March 2021 in our institute as well a critical review of literature of MRI in dermatomyositis.

Results: Muscle involvement is predominantly bilaterally symmetric and involves anterior, posterior as well as medial compartments of the thigh. Read More

View Article and Full-Text PDF

US estimates for dog bite injuries presenting to emergency departments.

S Ramgopal M L Macy

Public Health 2021 Jun 9;196:1-3. Epub 2021 Jun 9.

Division of Emergency Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Mary Ann & J. Milburn Smith Child Health Outcomes, Research, and Evaluation Center, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Objectives: Dog bites are a frequent source of injury requiring emergency department (ED) management. We sought to evaluate the longitudinal burden of dog bites presenting to US EDs.

Study Design: Cross-sectional study of a complex survey. Read More

View Article and Full-Text PDF

Acute experimental barrier injury triggers ulcerative colitis specific innate hyper-responsiveness and ulcerative colitis-type microbiome changes in humans.

Cell Mol Gastroenterol Hepatol 2021 Jun 9. Epub 2021 Jun 9.

Department of Gastroenterology, Herlev Hospital, University of Copenhagen, Denmark.

Background And Aims: The trigger hypothesis opens the possibility of anti-flare-initiation therapies by stating that ulcerative colitis (UC) flares originates from inadequate responses to acute mucosal injuries. However, experimental evidence is restricted by a limited use of suitable human models. We thus aimed to investigate the acute mucosal barrier injury responses in humans with and without UC using an experimental injury model. Read More

View Article and Full-Text PDF

Emerging role of Tissue Resident Memory T cells in vitiligo: From pathogenesis to therapeutics.

Autoimmun Rev 2021 Jun 9:102868. Epub 2021 Jun 9.

C. G. Bhakta Institute of Biotechnology, Uka Tarsadia University, Tarsadi, Surat 394350, Gujarat, India. Electronic address:

Vitiligo is an acquired depigmenting disorder which affects both skin and mucous membranes and autoimmunity has been strongly suggested to play a role in loss of melanocytes. The recurrence of skin macules at the same sites where they were observed prior to the treatment, suggests the existence of Tissue Resident Memory T cells (TRMs) that persist within the skin or peripheral tissues with a longer survivability. Emerging studies have shown that reactivation of these skin TRMs results into autoreactive TRM cells in various autoimmune diseases including vitiligo. Read More

View Article and Full-Text PDF

Reply to "Commentary on: Risk factors for postoperative morbidity after thyroid surgery in a PROSPECTIVE cohort of 1500 patients (Int. J. Surg. 2021, Epub ahead of print)".

Int J Surg 2021 Jun 9:105994. Epub 2021 Jun 9.

Centre for Translational Microbiome Research Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet, Stockholm, Sweden; Global Health Institute, University of Antwerp, Wilrijk, Belgium.

View Article and Full-Text PDF

Interpretation of genomic sequence variants in genetic skin diseases: A primer for clinicians.

J Am Acad Dermatol 2021 Jun 9. Epub 2021 Jun 9.

Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, and Jefferson Institute of Molecular Medicine, Thomas Jefferson University Philadelphia, PA; Jefferson Center for Heritable Connective Tissue and Skin Diseases, Thomas Jefferson University Hospital, Philadelphia, PA.

Over 1,000 heritable disorders have cutaneous manifestations, some of them being syndromic in association with extracutaneous manifestations, while others being limited to the skin. The genetic basis of many of these conditions has been deciphered, and mutation analysis by next-generation sequencing approaches, including whole-exome sequencing, whole-genome sequencing, and whole-transcriptome analysis, are now increasingly part of the diagnostic process. Besides confirming the diagnosis, information on the specific mutations can be used for sub-classification with prognostication and identification of carriers leading to accurate genetic counseling, and it also forms the basis for prenatal testing and preimplantation genetic diagnosis. Read More

View Article and Full-Text PDF

Delgocitinib ointment in pediatric patients with atopic dermatitis: a phase 3, randomized, double-blind, vehicle-controlled study and a subsequent open-label, long-term study.

J Am Acad Dermatol 2021 Jun 9. Epub 2021 Jun 9.

Pharmaceutical Division, Japan Tobacco Inc., Tokyo, Japan.

Background: Delgocitinib 0.5% ointment, a topical JAK inhibitor, has been approved for adult patients with atopic dermatitis (AD) in Japan.

Objective: To evaluate the efficacy and safety of delgocitinib ointment in pediatric patients with AD. Read More

View Article and Full-Text PDF

Molecular basis of anticoagulant and anti-complement activity of the tick salivary protein Salp14 and its homologues.

J Biol Chem 2021 Jun 9:100865. Epub 2021 Jun 9.

Department of Biochemistry, University of Maastricht, Cardiovascular Research Institute Maastricht (CARIM), Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands. Electronic address:

During feeding, a tick's mouthpart penetrates the host's skin and damages tissues and small blood vessels, triggering the extrinsic coagulation and lectin complement pathways. To elude these defense mechanisms, ticks secrete multiple anticoagulant proteins and complement system inhibitors in their saliva. Here we characterized the inhibitory activities of the homologous tick salivary proteins TSLPI, Salp14, and Salp9Pac from Ixodida scapularis in the coagulation cascade and the lectin complement pathway. Read More

View Article and Full-Text PDF

Novel archetype in psoriasis management bridging molecular dynamics in exploring novel therapies.

Eur J Pharmacol 2021 Jun 9:174254. Epub 2021 Jun 9.

University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, 492010, India. Electronic address:

Psoriasis is an autoimmune chronic inflammatory condition of skin affecting 125 million populaces around the globe. It is implicated as a result of multifaceted phenomena involving various cell and subcell activities with the aid of numerous cellular and molecular components including signaling aisle and regulatory proteins owing to the development of such hyperproliferative dermatological conditions. This involves a deeply complex and conflicting pathology owing to genetic and immunological deviations resulting from the unusual presentation of different signaling pathways and regulatory proteins. Read More

View Article and Full-Text PDF

Autoinflammatory keratinitzation diseases (AIKDs.

Actas Dermosifiliogr 2021 Jun 9. Epub 2021 Jun 9.

Servicio de Dermatología, Consorci Corporació Sanitària Parc Taulí, Universidad Autónoma de Barcelona, Spain.

Autoinflammatory keratinization disease (AiKD) is a novel clinical concept encompassing diseases with a genetic background and mixed pathogenic mechanisms of autoinflammation and autoimmunity, leading to an aberrant keratinization of the skin. Recent advances in medical genetics have revealed genetic causes and/or predisposing factors for a number of AiKD's, such as mutations in IL36RN related with pustular psoriasis, acrodermatitis continua and hidradenitis suppurativa, in CARD14 in pityriasis rubra pilaris type V and some forms of pustular psoriasis, and in NLRP1 related with familial keratosis lichenoides chronica (KLC). It is suspected that AiKD pathophysiology would also be involved in non-monogenic disorders. Read More

View Article and Full-Text PDF

The effectiveness of preoperative stoma site marking on patient outcomes: A systematic review and meta-analysis.

J Adv Nurs 2021 Jun 12. Epub 2021 Jun 12.

Department of Nursing, Yonsei Cancer Center, Yonsei University Health System, Seoul, Republic of Korea.

Aims: This study systematically reviews the literature regarding preoperative stoma site marking and discusses the effectiveness of the procedure on complication rates, self-care deficits and health-related quality of life (HRQOL).

Design: Systematic review and meta-analysis.

Data Source: Our review was conducted following the PRISMA guidelines. Read More

View Article and Full-Text PDF

Erythema and Acclimatization Following Repeated Sun Exposure: A Modelling Study.

Brian Diffey

Photochem Photobiol 2021 Jun 12. Epub 2021 Jun 12.

Dermatological Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4HH, UK.

The development of a computational model is described that allows time-varying erythema and acclimatization to be determined following repeated exposure to solar ultraviolet (UV) radiation. Good agreement was observed between experimental data and model predictions. Results are presented that illustrate how daily, adventitious sun exposure over the course of a year can result in occasional erythema generally in the late spring/early summer, whilst at the same time showing how the photoadaptive response of the skin changes throughout the year at different latitudes and for different sun reactive skin types. Read More

View Article and Full-Text PDF

An innovative adjustable prone positioning frame for treatment of severe kyphosis secondary to ankylosing spondylitis with two-level osteotomy.

Eur Spine J 2021 Jun 12. Epub 2021 Jun 12.

Mercy Medical Center, Trinity Health of New England, 271 Carew Street, Springfield, MA, 01104, USA.

Purpose: This study aims to introduce an innovative adjustable prone positioning frame (APPF) and explore its feasibility and safety for treatment of severe kyphosis secondary to ankylosing spondylitis (AS) with two-level osteotomy.

Methods: A retrospective, non-controlled study was conducted to illustrate the process where 13 patients diagnosed with severe kyphosis secondary to AS received operations on the APPF. Parameters of chin brow vertical angle (CBVA), global kyphosis (GK), thoracolumbar kyphosis (TLK), lumbar lordosis (LL) and sagittal vertical axis (SVA) were measured. Read More

View Article and Full-Text PDF

Current and emerging biological therapy in adult-onset Still's disease.

Rheumatology (Oxford) 2021 Jun 12. Epub 2021 Jun 12.

Department of Rheumatology and Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Adult-onset Still's disease (AOSD) is a rare, but characteristic non-familial, multi-genic systemic auto-inflammatory disorder, characterized by high spiking fever, salmon-like evanescent skin rash, polyarthritis, sore throat, hyperferritinemia, and leucocytosis. The hallmark of AOSD is a cytokine storm triggered by dysregulation of inflammation. Nowadays, with advances in anti-cytokine biologic agents, the treatment of AOSD is no longer limited to nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, or conventional synthetic disease modifying anti-rheumatic drugs (csDMARDs). Read More

View Article and Full-Text PDF

Objective and quantitative measurement of skin micro-relief by image analysis and application in age-dependent changes.

Skin Res Technol 2021 Jun 12. Epub 2021 Jun 12.

Faculty of Science and Technology, Keio University, Yokohama, Japan.

Background: Skin micro-relief has been researched by a variety of devices and methods, which usually are expensive or complicated. On the other hand, skin micro-relief relates to quite a few parameters, and it is hard to evaluate all of them at the same time. In the study, all parameters related to skin micro-relief are extracted and evaluated by image analysis. Read More

View Article and Full-Text PDF

Vulval lichen sclerosus: An Australasian management consensus.

Australas J Dermatol 2021 Jun 12. Epub 2021 Jun 12.

Northern Clinical School, The University of Sydney, Camperdown, New South Wales, Australia.

Background/objectives: Vulval lichen sclerosus (VLS) is a chronic inflammatory skin condition predominantly affecting the anogenital region in women and children. To date, there is lack of agreement amongst experts on a severity scale to aid assessment, research and treatment stratification on VLS. Furthermore, literature on best practice for long-term management of VLS is lacking. Read More

View Article and Full-Text PDF

Glutathione-Conjugated Hydrogels: Flexible Vehicles for Personalized Treatment of Bacterial Infections.

Pharm Res 2021 Jun 11. Epub 2021 Jun 11.

Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.

Purpose: Skin and soft tissue infections are increasingly prevalent and often complicated by potentially fatal therapeutic hurdles, such as poor drug perfusion and antibiotic resistance. Delivery vehicles capable of versatile loading may improve local bioavailability and minimize systemic toxicities yet such vehicles are not clinically available. Therefore, we aimed to expand upon the use of glutathione-conjugated poly(ethylene glycol) GSH-PEG hydrogels beyond protein delivery and evaluate the ability to deliver traditional therapeutic molecules. Read More

View Article and Full-Text PDF

Oroxylin A inhibits the migration of hepatocellular carcinoma cells by inducing NAG-1 expression.

Acta Pharmacol Sin 2021 Jun 11. Epub 2021 Jun 11.

State Key Laboratory of Natural Medicines, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China.

Hepatocellular carcinoma (HCC), the most prevalent liver cancer, is considered one of the most lethal malignancies with a dismal outcome mainly due to frequent intrahepatic and distant metastasis. In the present study, we demonstrated that oroxylin A, a natural product extracted from Scutellaria radix, significantly inhibits transforming growth factor-beta1 (TGF-β1)-induced epithelial-mesenchymal transition (EMT) and metastasis in HCC. Oroxylin A blocked the TGF-β1/Smad signaling via upregulating the non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) expression. Read More

View Article and Full-Text PDF

Scientific validation of three-dimensional stereophotogrammetry compared to the IGAIS clinical scale for assessing wrinkles and scars after laser treatment.

Sci Rep 2021 Jun 11;11(1):12385. Epub 2021 Jun 11.

Pharmaceutical Research Group, School of Allied Health, Faculty of Health, Education, Medicine and Social Care, Anglia Ruskin University, Bishops Hall Lane, Chelmsford, CM1 1SQ, UK.

Measuring outcomes from treatments to the skin is either reliant upon patient's subjective feedback or scale-based peer assessments. Three-Dimensional stereophotogrammetry intend to accurately quantify skin microtopography before and after treatments. The objective of this study is comparing the accuracy of stereophotogrammetry with a scale-based peer evaluation in assessing topographical changes to skin surface following laser treatment. Read More

View Article and Full-Text PDF

Detailed head localization and incidence of skin cancers.

Sci Rep 2021 Jun 11;11(1):12391. Epub 2021 Jun 11.

Department of Plastic, Reconstructive and Aesthetic Surgery, Second Chair of Surgery Medical, University of Lodz, Lodz, Poland.

Skin cancers are the most common neoplasms; frequently, they localize on the face. The aim of paper is to present the incidence of skin tumors in a single center from 2017 to 2019, describe trends in its frequency and find relations between neoplasms and sex, type of cancer, and its size. An analysis of histopathological files from the surgical department between 2017 and 2019 was calculated. Read More

View Article and Full-Text PDF

In-vitro and in-vivo study of the interference between Rift Valley fever virus (clone 13) and Sheeppox/Limpy Skin disease viruses.

Sci Rep 2021 Jun 11;11(1):12395. Epub 2021 Jun 11.

R&D Virology, MCI Santé Animale, Lot. 157, Z I, Sud-Ouest (ERAC), B.P. 278, 28810, Mohammedia, Morocco.

Viral interference is a common occurrence that has been reported in cell culture in many cases. In the present study, viral interference between two capripox viruses (sheeppox SPPV and lumpy skin disease virus LSDV in cattle) with Rift Valley fever virus (RVFV) was investigated in vitro and in their natural hosts, sheep and cattle. A combination of SPPV/RVFV and LSDV/RVFV was used to co-infect susceptible cells and animals to detect potential competition. Read More

View Article and Full-Text PDF

Safeguarding Skin Grafts: An Evidence-Based Summary of Fixation Techniques.

Ann Plast Surg 2021 Jun 10. Epub 2021 Jun 10.

From the Department of Plastic Surgery, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Background: Effective skin graft fixation is vital in preventing sheering forces, seroma, and hematoma from compromising graft take. Yet, selecting the ideal technique for securing skin grafts remains a contentious subject, with significant variation in practice existing between surgeons. There is, therefore, benefit to be derived from assessing the literature for evidence-based recommendations to guide the decision-making process. Read More

View Article and Full-Text PDF

Severe multisystem pathology, metabolic acidosis, mitochondrial dysfunction, and early death associated with an X-linked variant.

Cold Spring Harb Mol Case Stud 2021 Jun 11;7(3). Epub 2021 Jun 11.

Greenwood Genetic Center, Greenwood, South Carolina 29646, USA.

Variants in the X-linked gene (apoptosis-inducing factor mitochondria-associated 1) are associated with a highly variable clinical presentation that encompasses motor neuropathy, ataxia, encephalopathies, deafness, and cognitive impairment. encodes a mitochondrial flavin adenine dinucleotide (FAD)-dependent nicotinamide adenine dinucleotide (NADH) oxidoreductase, with roles in the regulation of respiratory complex assembly and function, production of reactive oxygen species, and the coordination of a caspase-independent type of apoptosis known as parthanatos. In this report, we describe a missense variant (absent in reference population databases; c. Read More

View Article and Full-Text PDF

Hyaluronic acid conjugates for topical treatment of skin cancer lesions.

Sci Adv 2021 Jun 11;7(24). Epub 2021 Jun 11.

School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

Skin cancer is one of the most common types of cancer in the United States and worldwide. Topical products are effective for treating cancerous skin lesions when surgery is not feasible. However, current topical products induce severe irritation, light-sensitivity, burning, scaling, and inflammation. Read More

View Article and Full-Text PDF

Vitamin D deficiency exacerbates UV/endorphin and opioid addiction.

Sci Adv 2021 Jun 11;7(24). Epub 2021 Jun 11.

Cutaneous Biology Research Center, Department of Dermatology and Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

The current opioid epidemic warrants a better understanding of genetic and environmental factors that contribute to opioid addiction. Here we report an increased prevalence of vitamin D (VitD) deficiency in patients diagnosed with opioid use disorder and an inverse and dose-dependent association of VitD levels with self-reported opioid use. We used multiple pharmacologic approaches and genetic mouse models and found that deficiencies in VitD signaling amplify exogenous opioid responses that are normalized upon restoration of VitD signaling. Read More

View Article and Full-Text PDF

Balanced Growth project: a protocol of a single-centre observational study on the involvement of the vestibular system in a child's motor and cognitive development.

BMJ Open 2021 Jun 11;11(6):e049165. Epub 2021 Jun 11.

Department of Rehabilitation Sciences, Ghent University Faculty of Medicine and Health Sciences, Ghent, Belgium.

Introduction: The involvement of the vestibular system in the motor and higher (cognitive) performances of typically developing or vestibular-impaired children is currently unknown or has only scarcely been explored. Interestingly, arguments for an interaction between vestibular, motor and cognitive functions in children can also be supported by research on children known for their difficulties in motor and/or cognitive processing (eg, children with neurodevelopmental disorders (NDD)), as they often present with vestibular-like characteristics. Therefore, in order to elucidate this interaction, and to increase the understanding of the pathophysiology and symptomatology of vestibular disorders and NDD in children, the Balanced Growth project was developed. Read More

View Article and Full-Text PDF

Fracture Stabilization and Management in the Field.

Vet Clin North Am Equine Pract 2021 Jun 8. Epub 2021 Jun 8.

The William R. Pritchard Veterinary Medical Teaching Hospital, University of California, Davis One Garrod Drive, Davis, CA 95616, USA; Department of Surgical and Radiological Sciences, UC Davis School of Veterinary Medicine, Davis, CA, USA.

Management of fractures in the field starts with successful assessment and stabilization of the patient by the practitioner on the front lines. A careful examination is vital to succesful patient management. This includes identifying the fracture location and severity, evaluating skin integrity and potential contamination of the fracture, and treating any ongoing hemorrhage, hypovolemia or stress. Read More

View Article and Full-Text PDF

Atopic dermatitis: Role of the skin barrier, environment, microbiome, and therapeutic agents.

J Dermatol Sci 2021 May 2. Epub 2021 May 2.

Department of Dermatology, Medical University Innsbruck, Innsbruck, Austria.

Atopic dermatitis (AD) is a chronic, inflammatory skin disorder characterized by eczematous and pruritic skin lesions. In recent decades, the prevalence of AD has increased worldwide, most notably in developing countries. The enormous progress in our understanding of the complex composition and functions of the epidermal barrier allows for a deeper appreciation of the active role that the skin barrier plays in the initiation and maintenance of skin inflammation. Read More

View Article and Full-Text PDF