Search Our Scientific Publications & Authors

J Burn Care Res 2019 Feb;40(2):242-245

Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, P. R. China.

This study aimed to introduce a novel technique for reconstructing electricity-damaged fingers using a method combining the free vascularized anterolateral thigh fascia lata flap with skin grafting. From February 2015 to March 2017, 11 patients were enrolled in this retrospective case series. All patients suffered from electrical injury of the fingers and had severe soft tissue defects, with the exposure of tendon, vessels, or nerves. Read More

Annu Rev Anal Chem (Palo Alto Calif) 2019 Feb 20. Epub 2019 Feb 20.

Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, USA; email:

Sweat is a largely unexplored biofluid that contains many important biomarkers ranging from electrolytes and metabolites to proteins, cytokines, antigens, and exogenous drugs. The eccrine and apocrine glands produce and excrete sweat through microscale pores on the epidermal surface, offering a noninvasive means for capturing and probing biomarkers, which reflect hydration state, fatigue, nutrition, and physiological changes. Skin-interfaced wearable sensors capable of real-time in situ sweat collection and analytics provide capabilities for continuous biochemical monitoring in an ambulatory mode of operation. Read More

Curr Protoc Pharmacol 2019 Feb 20:e55. Epub 2019 Feb 20.

Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.

Pemphigoid diseases (PDs) are a group of autoimmune bullous diseases characterized and caused by autoantibodies targeting structural proteins of the skin and mucous membranes. Chronic inflammation, subepidermal blistering, and often scaring are the clinical characteristics of PDs. Itching and, in severe cases, disabilities resulting from scaring (i. Read More

Small 2019 Feb 20:e1900046. Epub 2019 Feb 20.

Frontier Institute of Science and Technology, and State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an, 710049, China.

Developing injectable nanocomposite conductive hydrogel dressings with multifunctions including adhesiveness, antibacterial, and radical scavenging ability and good mechanical property to enhance full-thickness skin wound regeneration is highly desirable in clinical application. Herein, a series of adhesive hemostatic antioxidant conductive photothermal antibacterial hydrogels based on hyaluronic acid-graft-dopamine and reduced graphene oxide (rGO) using a H O /HPR (horseradish peroxidase) system are prepared for wound dressing. These hydrogels exhibit high swelling, degradability, tunable rheological property, and similar or superior mechanical properties to human skin. Read More

Skin Res Technol 2019 Feb 20. Epub 2019 Feb 20.

Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee.

Background: Estimating the extent of affected skin is an important unmet clinical need both for research and practical management in many diseases. In particular, cutaneous burden of chronic graft-vs-host disease (cGVHD) is a primary outcome in many trials. Despite advances in artificial intelligence and 3D photography, progress toward reliable automated techniques is hindered by limited expert time to delineate cGVHD patient images. Read More

J Dermatol 2019 Feb 20. Epub 2019 Feb 20.

Department of Dermatology, Venereology and Allergology, University Clinic Göttingen, Göttingen, Germany.

Palmoplantar pustular psoriasis, also termed palmoplantar pustulosis (PPP), is a rare disease affecting the palmoplantar regions characterized by sterile, yellow to brown pustules mostly on erythematous skin. PPP is related to a high burden due to painful, impaired and stigmatizing character. Several isoforms of interleukin (IL) have been implicated in its pathophysiology. Read More

Laryngoscope 2019 Feb 20. Epub 2019 Feb 20.

Netherlands Cancer Institute, Amsterdam, New Zealand.

Objectives: The aim of this study was to compare the relative compliance and the dermatological and pulmonary outcomes when the Provox Luna system (Atos Medical, Malmö, Sweden) is added during the night to the usual tracheastoma care of laryngectomized subjects.

Methods: This was a multicenter randomized crossover trial conducted in the Netherlands Cancer Institute, Erasmus Medical Center, and Maastricht University Medical Center in The Netherlands. The study included 46 laryngectomized subjects with prior heat and moisture exchanger (HME) and adhesive experience. Read More

Br J Dermatol 2019 Feb 20. Epub 2019 Feb 20.

Dermatology Department, University General Hospital of Patras, Greece.

A disproportional number of movie villains have skin dosorders . However, it is not only in Hollywood that this is over-represented, it is seen in other forms of art and human expression, including classic and contemporary literature. This article is protected by copyright. Read More

Int J Cancer 2019 Feb 20. Epub 2019 Feb 20.

Institute of Virology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Fürst-Pückler-Str. 56, 50935 Cologne, Germany.

Human papillomavirus 8 (HPV8) is associated with the development of squamous cell carcinomas (SCC) of the skin. HPV-infected keratinocytes are able to over-ride normal checkpoint control mechanisms and sustain cell cycle activity, allowing for synthesis of cellular proteins necessary for viral genome amplification. To study how HPV8 may disrupt cell-cycle control, we analysed the impact of HPV8 early gene expression on one of the key regulators of cell cycle and DNA damage response, checkpoint kinase-1 (CHK1). Read More

J Anat 2019 Feb 20. Epub 2019 Feb 20.

Laboratory Medicine & Pathobiology, University of Toronto, Toronto, ON, Canada.

Severe cutaneous wounds expose the body to the external environment, which may lead to impairments in bodily functions and increased risk of infection. There is a need to develop skin substitutes which could effectively promote complete skin regeneration following an injury. Murine models are used to test such skin substitutes, but their healing involves contraction of the dermis not found in human wounds. Read More

Eur J Immunol 2019 Feb 20. Epub 2019 Feb 20.

Institut für Neuroimmunologie und Multiple Sklerose, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.

The key function of migratory dendritic cells (migDCs) is to take up antigens in peripheral tissues and migrate to draining lymph nodes (dLN) to initiate immune responses. Recently, we discovered that in the mouse immune system activity-regulated cytoskeleton associated protein/activity-regulated gene 3.1 (Arc/Arg3. Read More

PLoS One 2019 20;14(2):e0210831. Epub 2019 Feb 20.

School of Biological Sciences, University of Bristol, Bristol, United Kingdom.

Averting attack by biting flies is increasingly regarded as the evolutionary driver of zebra stripes, although the precise mechanism by which stripes ameliorate attack by ectoparasites is unknown. We examined the behaviour of tabanids (horse flies) in the vicinity of captive plains zebras and uniformly coloured domestic horses living on a horse farm in Britain. Observations showed that fewer tabanids landed on zebras than on horses per unit time, although rates of tabanid circling around or briefly touching zebra and horse pelage did not differ. Read More

J Clin Oncol 2019 Feb 20:JCO1801223. Epub 2019 Feb 20.

11 Yeouido St Mary's Hospital College of Medicine, The Catholic University of Korea, Seoul, Korea.

Purpose: Recent studies indicated that the autoimmunity of vitiligo exerts effects on cells other than melanocytes, which confer reduced risks of both melanoma and nonmelanoma skin cancers in patients with vitiligo. However, the risk of internal malignancy in patients with vitiligo has not been elucidated.

Patients And Methods: We conducted a population-based retrospective cohort study using data from the Korean National Health Insurance claims database obtained from January 2007 to December 2016. Read More

J Neurophysiol 2019 Feb 20. Epub 2019 Feb 20.

Institute of Neuroscience (IONS), Universite catholique de Louvain, Belgium.

High frequency electrical stimulation (HFS) of skin nociceptors triggers central sensitization (CS), manifested as increased pinprick sensitivity of the skin surrounding the site of HFS. Our aim was to assess the effect of CS on pinprick-evoked pupil dilation responses (PDRs) and pinprick-evoked brain potentials (PEPs). We hypothesized that the increase in the positive wave of PEPs following HFS would result from an enhanced pinprick-evoked phasic response of the locus coeruleus-noradrenergic system (LC-NS), indicated by enhanced PDRs. Read More

Arch Pathol Lab Med 2019 Feb 20. Epub 2019 Feb 20.

From the Department of Dermatology, Saint Louis University, St Louis, Missouri (Dr Abate);the Departments of Dermatology (Dr Battle),and Pathology (Drs Gardner and Shalin),University of Arkansas for Medical Sciences, Little Rock; and the Department of Dermatology, University of Mississippi Medical Center, Jackson (Dr Emerson).

Context.—: Fatal dermatologic diseases and ones with high morbidity can occur in the inpatient setting. In such cases, prompt and accurate assessment of a bedside skin biopsy is required. Read More

Int Braz J Urol 2019 Feb 15;45. Epub 2019 Feb 15.

Department of Urology, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey.

Objective: The pathophysiology of urethral stricture and its recurrence remains vague and one of the important causes is progressive infl ammation. It has been shown in recent years that the neutrophil / lymphocyte ratio is a marker of systemic infl ammation and is associated with prognosis in many cardiovascular diseases, malignancies and chronic infl ammatory diseases. We assessed simple systemic infl ammation markers preoperatively and surgical techniques for urethral stricture recurrence after urethroplasty. Read More

Rev Med Suisse 2019 Feb;15(639):418-421

Service de néphrologie et d'hypertension, CHUV, 1011 Lausanne.

The skin is the largest human organ playing an important role in protection, thermoregulation and sensation. Recent studies suggest that a new function has to be added: the storage of sodium. There is increasing evidence that sodium can accumulate in the skin, which suggests that the skin contributes to the regulation of sodium balance in humans, and possibly to the control of extracellular volume and blood pressure homeostasis. Read More

Rev Inst Med Trop Sao Paulo 2019 Feb 14;61:e5. Epub 2019 Feb 14.

Universidade Federal de Minas Gerais, Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Belo Horizonte, Minas Gerais, Brazil.

The Mitsuda test is a skin test based on the individual's immune response through late and highly specific hypersensitivity reaction to the Mycobacterium leprae bacillus. A negative reaction identifies individuals who present a higher risk of becoming ill if exposed to M. leprae and, if they become ill, to develop the virchowian form of disease. Read More

Rev Soc Bras Med Trop 2019 Feb 14;52:e20160502. Epub 2019 Feb 14.

School of Medicine, Universidad del Valle, Cali, Colombia.

Histoid leprosy is an uncommon form of lepromatous leprosy with distinct clinical, histopathological, immunological, and bacteriological features. This variant usually occurs in multibacillary patients who have irregular or inadequate treatment. Herein, we report a case of de novo histoid leprosy diagnosed in a patient from Cali, Colombia. Read More

Arq Gastroenterol 2018 Oct-Dec;55(4):375-379

Universidade de Fortaleza, Centro de Ciências da Saúde, Curso de Medicina, Programa de Educação Tutorial, Fortaleza, CE, Brasil.

Background: Paracentesis is a routine medical procedure quite relevant in clinical practice. There are risks of complications related to paracentesis, so it is essential a proper trainee for the younger practicer.

Objective: The article describes the construction and the application of a low cost paracentesis simulator for undergraduate medical students and it also describes the perception of students about the simulator as well. Read More

Acta Cir Bras 2019 Feb 14;34(1):e20190010000004. Epub 2019 Feb 14.

Associate Professor, Department of Surgery, and Permanent Instructor, Postgraduate in Surgical Medicine, UFPR, Curitiba-PR, Brazil. Technical procedures.

Purpose: To characterize qualitatively and quantitatively the absorption of metronidazole solution, in greater concentrations and for longer periods, when applied topically to an experimental open skin wound model.

Methods: An open skin wound, 2 cm in diameter and total skin thickness was prepared, under anesthetic, in the dorsal region of 108 Wistar rats weighing between 300 and 350 grams. The animals were allocated to groups of 18 animals in accordance with the concentration of metronidazole in the solution to be applied daily to the wound. Read More

Cad Saude Publica 2019 Feb 18;35(2):e00008618. Epub 2019 Feb 18.

Universidade Federal de Pelotas, Pelotas, Brasil.

The article sought to describe awareness of public physical activity programs, practice of physical activity in public programs and barriers related to non-participation in these programs in a national representative sample according to sex, age, skin color, income, state and having been visited by a family health team (EqSF, in Portuguese) in the previous year. This is a cross-sectional survey with data from the Brazilian National Health Survey, 2013. We carried out descriptive analyses using the distribution of relative frequencies and their respective 95% confidence intervals, weighted in the sample design. Read More

Braz J Med Biol Res 2019 Feb 14;52(2):e8209. Epub 2019 Feb 14.

Programa de Pós-Graduação em Ciências Farmacêuticas, Laboratório de Produtos Naturais, Universidade Vila Velha, Vila Velha, ES, Brasil.

Vegetable oils have been used for a plethora of health benefits by their incorporation in foods, cosmetics, and pharmaceutical products, especially those intended for skin care. This study aimed to investigate the cutaneous benefits of a vegetable oil blend (VOB) formulation and its fatty acid composition. The anti-inflammatory activity was studied in macrophages of RAW 264. Read More

Einstein (Sao Paulo) 2019 Feb 18;17(1):eRC4504. Epub 2019 Feb 18.

Complejo Hospitalario de Navarra, Pamplona, Navarra, Spain.

Kaposi sarcoma is an angioproliferative disorder that ranges from a single indolent skin lesion to respiratory and gastrointestinal/visceral involvement. Kaposi sarcoma is rare in non-immunosuppressed patients. Nineteen cases of penile Kaposi sarcoma in HIV-negative patients were reported in 2012. Read More

Hum Vaccin Immunother 2019 Feb 20. Epub 2019 Feb 20.

a Department of Dermatology , University of California, San Francisco , San Francisco.

Dupilumab is a fully human monoclonal IgG4 antibody directed against the alpha subunit of the IL-4 receptor and prevents the signaling of IL-4 and IL-13, two type 2 cytokines known to be important drivers of atopic diseases. In March of 2017, the United States Food and Drug Administration (FDA) approved dupilumab for the treatment of moderate-to-severe atopic dermatitis in adults that is uncontrolled with topical medications, becoming the first biologic agent approved to treat this chronic skin condition. In October of 2018, Dupilumab received approval by the FDA as an add-on maintenance therapy in patients with moderate-to-severe asthma aged 12 years or older with an eosinophilic phenotype or with oral corticosteroid-dependent asthma. Read More

Ideggyogy Sz 2019 Jan;72(1-2):65-70

Szegedi Tudományegyetem, Általános Orvostudományi Kar, Szent-Györgyi Albert Klinikai Központ, Neurológiai Klinika, Szeged.

Hereditary hemorrhagic teleangiectasia (HHT, Osler-Rendu-Weber disease) is an autosomal dominantly inherited disorder caused by the mutation of several possible genes and characterized by malformations of the arteriovenous system in multiple organs. The clinical diagnosis is based on the Curaçao criteria ((1) spontaneous, recurrent epistaxis; (2) teleangiectasias in characteristic sites (lips, oral cavity, nose, fingers); (3) visceral lesions (gastrointestinal, pulmonary, cerebral, spinal); (4) affected first degree relative). The aim of this study is to present the first genetically confirmed Hungarian case of hereditary hemorrhagic teleangiectasia with multiple ischemic strokes. Read More

Indian J Dermatol Venereol Leprol 2019 Feb 19. Epub 2019 Feb 19.

Department of Pathology, University of Chile Clinical Hospital, Santiago, Chile.

Indian J Dermatol Venereol Leprol 2019 Feb 19. Epub 2019 Feb 19.

Department of Polymer Engineering, Amirkabir University of Technology, Tehran, Iran.

Background: Chitosan has a biocompatible, biodegradable and nontoxic nature. The effectiveness of nano-chitosan films in the treatment of cutaneous leishmaniasis has been confirmed previously in susceptible laboratory animals.

Aims: The aim of this study is to evaluate the safety and efficacy of a chitosan-based biocompatible dressing in patients with cutaneous leishmaniasis who were either nonresponsive to or had medical contraindications for conventional treatments. Read More

J Investig Allergol Clin Immunol 2019 Feb;29(1):62-64

Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Forensic Sci Int Genet 2019 Feb 11;40:105-113. Epub 2019 Feb 11.

Zurich Institute of Forensic Medicine, University of Zurich, Winterthurerstrasse 190/52, CH-8057, Zurich, Switzerland. Electronic address:

In the forensic reconstruction of crime scene activities, the identification of biological traces and their bodily origin are valuable evidence that can be presented in court. While several presumptive and confirmatory tests are currently available, the limitations in specificity and sensitivity have instigated a search for alternative methods. Bacterial markers have been proposed as a novel approach for forensic body fluid/tissue identification. Read More

Phytomedicine 2018 Dec 17;57:215-222. Epub 2018 Dec 17.

Department of Pharmacognosy and Molecular Basis of Phytotherapy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.

Background: Among solar radiation, ultraviolet light is the most harmful for the skin, because of intracellular reactive oxygen species formation, leading to oxidative stress, cell damage and apoptosis. Crucial role in skin protection against oxidative stress play antioxidant enzymes regulated by Nrf2 transcription factor. Some plant-derived polyphenols are known to protect skin fibroblasts against UV through induction of Nrf2-dependent antioxidant genes expression. Read More

Eur J Cancer 2019 Feb 19;110:120-126. Epub 2019 Feb 19.

Department of Epidemiological Research and Molecular Medicine, Evaluative Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Italy. Electronic address:

Although all tumours are rare in childhood, there are some particularly rare paediatric cancers which have not benefited from advances made by the international paediatric oncology network. To establish a shared definition and produce a list of these entities, the European Union Joint Action on Rare Cancers (JARC) promoted a consensus effort. The definition was based on the incidence rates estimated using the information network on rare cancers (RARECAREnet) database, pooling data from 94 population-based cancer registries and 27 countries. Read More

Clin Neurophysiol 2019 Feb 4;130(4):528-536. Epub 2019 Feb 4.

Department of Neurology, University of Würzburg, Germany; Fabry Center for Interdisciplinary Therapy (FAZIT), University of Würzburg, Germany. Electronic address:

Objective: To investigate A-delta fiber conduction in mild to moderate Fabry disease (FD) patients using pain-related evoked potentials (PREP).

Methods: In this case-control study we prospectively investigated 58 patients with mild to moderate FD and compared data with those of healthy controls. Small fiber function (quantitative sensory testing, QST and sympathetic skin response, SSR), morphology (intraepidermal nerve fiber density, IENFD), and electrical conduction (PREP) were assessed and correlated with sweating as major autonomic function disturbed in FD. Read More

Forensic Sci Int 2019 Feb 8;297:111-131. Epub 2019 Feb 8.

Formerly of Iowa Division of Criminal Investigation Criminalistics Laboratory, Ankeny, IA, United States.

This study addresses the permanence and persistence of friction ridges and the persistence of impressions made from these friction ridges over months and years. Permanence is the unchanging presence and appearance of friction ridge arrangements and their attributes between recurring observations of the skin. Permanence was evaluated from direct photographs of fingers collected over a period of 30-45 days (covering one or more skin regeneration cycles) as well as after 8 or more years had elapsed. Read More

Biomed Pharmacother 2019 Feb 19;112:108615. Epub 2019 Feb 19.

University Institute of Pharmacy, Pt. Ravishankar Shukla University, 492010, Raipur, C.G., India. Electronic address:

Wound management in diabetic patient is of an extreme clinical and social concern. The delayed and impaired healing makes it more critical for research focus. The research on impaired healing process is proceeding hastily evident by new therapeutic approaches other than conventional such as single growth factor, dual growth factor, skin substitutes, cytokine stimulators, cytokine inhibitors, matrix metalloproteinase inhibitors, gene and stem cell therapy, extracellular matrix and angiogenesis stimulators. Read More

Aquat Toxicol 2019 Feb 13;209:168-177. Epub 2019 Feb 13.

Department of Life Science, School of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan. Electronic address:

This study aimed to assess the sublethal effects of a platinum-based compound, cisplatin, using a zebrafish model. Zebrafish embryos were incubated in different concentrations of cisplatin at 0-96 h post-fertilization. Using a non-invasive, scanning ion-selective electrode technique (SIET), we measured the functions of hair cells (Ca influx) and ionocytes ([H] gradients). Read More

Biomaterials 2019 Feb 13;201:33-41. Epub 2019 Feb 13.

Van 't Hoff Institute for Molecular Sciences. University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, the Netherlands. Electronic address:

A perfect "off" to "on" switch of the therapeutic function is very important to minimize the phototoxicity of nanoplatforms assisted imaging-guided photodynamic therapy (PDT) of cancer. Current approaches rely on preloaded photosensitizers, where the off/on state of PDT is regulated by the sensitizing light of photosensitizers. However, the photoactivities inevitably occur when imaging/diagnosis or exposure to sunlight, etc. Read More

J Therm Biol 2019 Feb 7;80:94-105. Epub 2019 Jan 7.

Faculty of Mechanical Engineering, University of Maribor, 2000, Slovenia.

The one-dimensional steady Pennes (bioheat) equation was applied to analyze heat conduction inside a combined layer of human muscle and fat, under Fanger thermal comfort conditions. The bioheat equation was solved subject to two boundary conditions at the skin surface: a prescribed skin temperature satisfying the Fanger comfort criterion, and a prescribed heat flux obtained from the overall energy balance for the system. In addition to a fixed body core temperature, an adiabatic condition was imposed as an auxiliary condition at the core of the body, and a pair of equations were derived, relating the blood perfusion and the volumetric heat generation rate for a given activity level and environmental conditions. Read More

J Therm Biol 2019 Feb 9;80:82-88. Epub 2019 Jan 9.

Science Research Department, Alexander Muss High School in Israel (AMHSI) affiliated to the Alexander Muss Institute for Israel Education (AMIIE), Hod HaSharon, Israel. Electronic address:

The continuing development and manufacture of infrared devices, together with improvements in thermal body mapping techniques have simplified surface skin thermography which is being used more extensively than ever before. Normative thermography data, however, remains incomplete. A normative blood redistribution range of skin temperatures was established for use as a reference for laboratory infrared thermography (IT), thermal body mapping, and mass fever screenings. Read More

Int J Med Inform 2019 Apr 18;124:37-48. Epub 2019 Jan 18.

School of Computer Science and Engineering, Korea University of Technology and Education, 1600, Chungjeol-ro, Byeongcheon-myeon, Dongnam-gu, Cheonan-si, Chungcheongnam-do, 31253, Republic of Korea. Electronic address:

Objective: Melanoma is a dangerous form of the skin cancer responsible for thousands of deaths every year. Early detection of melanoma is possible through visual inspection of pigmented lesions over the skin, treated with simple excision of the cancerous cells. However, due to the limited availability of dermatologists, the visual inspection alone has the limited and variable accuracy that leads the patient to undergo a series of biopsies and complicates the treatment. Read More

J Feline Med Surg 2019 Feb 20:1098612X19829910. Epub 2019 Feb 20.

2 Valley Fever Center for Excellence, University of Arizona, Tucson, AZ, USA.

Objectives: The goal of this study was to describe the clinical presentation, diagnosis and treatment of coccidioidomycosis in cats residing in a region endemic for Coccidioides species.

Methods: A retrospective review of records was performed at both primary and tertiary care veterinary practices in Tucson and Phoenix, Arizona. Data collected included signalment, clinical signs, physical examination findings, diagnostic test results, treatment and outcome. Read More

J Agric Food Chem 2019 Feb 20. Epub 2019 Feb 20.

Objectives of the present study were to evaluate amounts of collagen in Japanese daily dishes and contents of food-derived collagen peptides in human blood. The meat in one serving of most Japanese daily dishes contains 0.2-2. Read More

Stem Cells Transl Med 2019 Feb 19. Epub 2019 Feb 19.

Department of Orthopedics and Rehabilitation, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Patients with type 1 diabetes mellitus (T1DM) often suffer from osteopenia or osteoporosis. Although most agree that T1DM-induced hyperglycemia is a risk factor for progressive bone loss, the mechanisms for the link between T1DM and bone loss still remain elusive. In this study, we found that bone marrow-derived mesenchymal stem cells (BMSCs) isolated from T1DM donors were less inducible for osteogenesis than those from non-T1DM donors and further identified a mechanism involving bone morphogenetic protein-6 (BMP6) that was produced significantly less in BMSCs derived from T1DM donors than that in control cells. Read More

Int Wound J 2019 Feb 19. Epub 2019 Feb 19.

Reading Hospital, Tower Health System, West Reading, Pennsylvania.

Negative pressure wound therapy with instillation and dwell time (NPWTi-d) is an automated system used to deliver, dwell, and remove topical solutions from the wound bed. Recently, a reticulated open cell foam dressing with through holes (ROCF-CC) was developed, which assists with wound cleansing by removing thick exudate and infectious materials. We present our experience using NPWTi-d with ROCF-CC on complex wounds when complete surgical debridement was inappropriate because of medical instability, recurrent non-viable tissue, or palliative treatment plan. Read More

Zoonoses Public Health 2019 Feb 19. Epub 2019 Feb 19.

Istituto Zooprofilattico Sperimentale del Lazio e della Toscana "M. Aleandri", Rome, Italy.

Swimmer's itch is caused by the penetration of free-swimming larvae of trematodes of the family Schistosomatidae in human skin. It is usually reported in people engaged in recreational water activities in freshwater bodies and in most of cases, it is provoked by bird schistosomes of the genus Trichobilharzia. In the summer 2017, many cases of dermatitis were recorded in people bathing in the waters of the Albano Lake (Rome, Italy) and a parasitological investigation was carried out in order to ascertain the causative agent of these cases. Read More

J Cosmet Dermatol 2019 Feb 19. Epub 2019 Feb 19.

Department of Chemistry, The American University in Cairo, Cairo, Egypt.

Background: Solid lipid nanoparticles (SLNs) are dispersions synthesized by replacing liquid lipid in an o/w emulsion with solid lipids. Nanostructured lipid carriers (NLCs) improve on some of the major limitations of the SLNs as NLCs use liquid lipids along with crystalline solid fatty acids to build the core.

Aims: This work aims to investigate the potential advantage of using Prickly Pear (PP) seed oil to develop NLCs for topical delivery of vitamin A. Read More

J Eur Acad Dermatol Venereol 2019 Feb 19. Epub 2019 Feb 19.

Department of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, P. R. China.

Background: Extramammary Paget's disease (EMPD) is a rare skin cancer with relative high frequencies of germline and somatic mismatch repair (MMR) genes mutations. However, the methylation and expression of these genes have not been validated in EMPD.

Objective: This study aims to confirm the methylation and expression of MMR genes in EMPD. Read More

Clin Anat 2019 Feb 19. Epub 2019 Feb 19.

University of Arkansas for Medical Sciences, Little Rock, Arkansas.

The posterior approach is a commonly employed exposure of the elbow that provides excellent visualization and efficacy for various orthopedic procedures, including total elbow arthroplasty (TEA) and fracture care. The posterior approach to the elbow has been associated with an increased rate of wound complications, including infection, skin necrosis, and wound dehiscence. Despite an association between these complications and decreased elbow perfusion, data regarding the intrinsic anatomic etiology for preferential complications in this area has been scarcely reported in the literature. Read More

Clin Exp Dermatol 2019 Feb 19. Epub 2019 Feb 19.

Department of Dermatology, Churchill Hospital, Old Road, Oxford, OX3 7LE, UK.

Skin conditions are common in adolescence and impart considerable psychological burden. The Department of Health has identified the specialised needs of adolescents transitioning from paediatric to adult services as a priority, yet there are few dedicated transitional clinics in the UK providing appropriate psychosocial support. We have established a monthly Teenage and Young Adult (TYA) clinic dedicated to managing teenagers and young adults with skin disease alongside open-access psychological support. Read More

Contact Dermatitis 2019 Feb 19. Epub 2019 Feb 19.

Department of Conservative Dentistry and Periodontology, University Hospital, LMU Munich, Germany.

Background: Glucose monitoring systems, eg Freestyle Libre (Abott) and Dexcom (Nintamed) more and more replace conventional blood sugar measurement. However, many patients experienced adverse skin reactions such as severe allergic contact dermatitis (ACD). Finally, in August 2017 the culprit allergen in Freestyle Libre, isobornyl acrylate (IBOA), was identified. Read More