Search Our Scientific Publications & Authors

Int Immunopharmacol 2019 Apr 17;72:308-321. Epub 2019 Apr 17.

Department of Dermatology, The First Hospital of China Medical University, Shenyang 110001, PR China; Key Lab of Dermatology, Ministry of Education and Public Health, National joint Engineering Research Center for Theranostics of Immunological Skin Diseases, Shenyang 110001, PR China. Electronic address:

Candida albicans is a commensal fungus that associates with human hosts. Under normal circumstances this interaction does not produce any severe life-threatening disease, as macrophages of the innate immune system will result in its clearance. However, disorders may arise in immunosuppressed individuals. Read More

Int Immunopharmacol 2019 Apr 17;72:284-291. Epub 2019 Apr 17.

Department of Immunology, Basic Medical College of Qingdao University, Qingdao 266071, China.

Imiquimod (Imiq) is a synthetic imizoquinoline compound which can act on Toll-like receptor (TLR)7 and transduce signals involved in cell activation. We investigated the role of Imiq on contact hypersensitivity (CHS) and explored the potential mechanisms of mast cells involved in the process. Topical application of Imiq cream augmented DNFB mediated CHS in C57BL/6 mice. Read More

Phytomedicine 2019 Feb 26;58:152879. Epub 2019 Feb 26.

Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Taoyuan, Taiwan, ROC; Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC. Electronic address:

Background: Anti-angiogenesis is an important strategy of psoriasis treatment, but the side effects of systemic agents remain difficult to overcome. Topical use of indigo naturalis ointment has been proved to improve the skin lesion of psoriasis effectively and safely and one of its major components, tryptanthrin, has been demonstrated to have anti-angiogenic effect. Apelin, which has been reported to act as an angiogenic factor that could stimulate the proliferation and migration of vascular endothelial cells and proved to be elevated in psoriasis patients, is a potential target of anti-angiogenic therapy. Read More

Stem Cell Res 2019 Apr 15;37:101438. Epub 2019 Apr 15.

Institute for Regenerative Medicine and Biotherapy (IRMB), Montpellier, France; Hopital St Eloi, CHU Montpellier, 80 rue augustin Fliche, 30295 Montpellier, France. Electronic address:

Induced pluripotent stem cells (iPSC) were generated from skin fibroblasts obtained from a 58 year-old woman suffering from Alzheimer's disease and carrying a D694N mutation on Amyloid precursor protein (APP). Fibroblasts were reprogrammed into iPSC using the integration-free Sendai Virus which allows the expression of the Yamanaka factors. Verification of their pluripotency was achieved by demonstrating the expression of pluripotency markers and their differentiation potential into the three primary germ layers. Read More

J Surg Res 2019 Apr 17;241:15-23. Epub 2019 Apr 17.

Division of Surgical Oncology, Department of Surgery, Rutgers New Jersey Medical School, Newark, New Jersey. Electronic address:

Background: Sentinel lymph node biopsy (SLNB) has shown promise in identifying subclinical nodal metastasis in patients with high-risk cutaneous squamous cell carcinoma. However, low metastasis rates may indicate that performing such a procedure in all patients may be unnecessary and costly.

Materials And Methods: A decision model was developed to analyze costs and survival in patients with head and neck cutaneous squamous cell carcinoma based on their tumor and nodal metastasis staging and whether or not they received an SLNB. Read More

Acta Biomater 2019 Apr 17. Epub 2019 Apr 17.

Laboratory of Bioregenerative Medicine & Surgery, Division of Plastic Surgery, Weill Cornell Medical Center, 1300 York, Room A-821, New York, NY 10021, United States; Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, 121A Weill Hall, Ithaca, NY 14853, United States. Electronic address:

Introduction: Insufficient vascularization of currently available clinical biomaterials has limited their application to optimal wound beds. We designed a hydrogel scaffold with a unique internal microstructure of differential collagen densities to induce cellular invasion and neovascularization.

Methods: Microsphere scaffolds (MSS) were fabricated by encasing 1% (w/v) type 1 collagen microspheres 50-150 μm in diameter in 0. Read More

Nanomedicine 2019 Apr 17. Epub 2019 Apr 17.

Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, 08028 Barcelona, Spain; Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Granada, Spain. Electronic address:

Pioglitazone (PGZ) is a peroxisome proliferator-activated receptor agonist. Its role in the inflammatory response modulation opens the door for additional therapeutic applications. The purpose of this study was to develop a pioglitazone nanoemulsion (PGZ-NE) to investigate its anti-inflammatory efficacy on the skin. Read More

Free Radic Biol Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Dermatology, Medical University of Vienna, Austria; Christian Doppler Laboratory for the Biotechnology of Skin Aging, Vienna, Austria.

Dermatological research is a major beneficiary of the rapidly developing advances in lipid analytic technology and of bioinformatic tools which help to decipher and interpret the accumulating big lipid data. At its interface with the environment, the epidermis develops a blend of lipids that constitutes the epidermal lipid barrier, essential for the protection from water loss and entry of dangerous noxae. Apart from their structural role in the barrier, novel intra- and inter-cellular signaling functions of lipids and their oxidation products have been uncovered in most cutaneous cell types over the last decades, and the discovery rate has been boosted by the advent of high resolution and -throughput mass spectrometric techniques. Read More

Biol Blood Marrow Transplant 2019 Apr 17. Epub 2019 Apr 17.

Brigham and Women's Hospital, Department of Infectious Diseases, Boston, Massachusetts; Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, Massachusetts.

Allogeneic hematopoietic cell transplant (HCT) recipients are at increased risk for varicella zoster virus reactivation and associated complications. The incidence, timing, and risk factors for severe herpes zoster (HZ) are not well described in the era of acyclovir (ACV) prophylaxis. We performed a retrospective cohort study of all patients who underwent first allogeneic HCT from October 2006 to December 2015 at our institution. Read More

Int J Pharm 2019 Apr 17. Epub 2019 Apr 17.

Department of Pharmaceutics & Biopharmaceutics, Philipps-Universität Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany. Electronic address:

At present, there is an increasing demand to improve the sustainability of surface-active compounds in dermal formulations. Biosurfactants, which are derived from living cells, are considered to be more environmentally friendly than synthetic surfactants. Thus, the use of biosurfactants is a promising strategy for the formulation of more environmentally friendly and sustainable dermal products. Read More

Life Sci 2019 Apr 17. Epub 2019 Apr 17.

Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA. Electronic address:

Collagen is the most abundant protein in mammalian systems; it can be found in organs such as bones, the liver, kidney, heart, teeth, and skin. Collagen provides the necessary structural framework for tissues in which it is found. However, if there are any alterations in the delicate balance of collagen types in the extracellular matrix (ECM), then problems arise. Read More

J Allergy Clin Immunol 2019 Apr 17. Epub 2019 Apr 17.

Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery and Miami Itch Center Miller School of Medicine University of Miami, Miami, FL. Electronic address:

Pruritus is a sensation that emanates from the skin and is transferred via peripheral nerve fibers to the central nervous system. It is easily understood that primary skin disorders such as atopic eczema, skin dryness, psoriasis, and urticaria can elicit pruritus. However certain systemic diseases can cause chronic pruritus that have significant impact on patients' quality of life. Read More

Clin Endocrinol (Oxf) 2019 Apr 20. Epub 2019 Apr 20.

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy.

Background And Objectives: Critically-ill patients present reduced endogenous melatonin blood levels, and they might benefit from its exogenous supplementation. The aim of this research was to evaluate the feasibility of different routes of administration and drug formulations of melatonin. The efficiency of absorption was assessed as well as the adequacy in achieving and maintaining the physiological nocturnal blood peak. Read More

Br J Dermatol 2019 Apr 20. Epub 2019 Apr 20.

Department of Dermatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Ingenol mebutate is a macrocyclic diterpene ester, naturally found in the sap of the Australian plant Euphorbia peplus, which proved efficacious for actinic keratosis. In clinical routine, we observed local improvement of MF upon application of ingenol mebutate in MF patients treated for coincidental actinic keratosis within direct proximity of/overlapping with MF skin lesions. Hence, the objective of this study was to assess the effect of topical ingenol mebutate on MF skin lesions. Read More

Clin Pharmacol Ther 2019 Apr 20. Epub 2019 Apr 20.

Taiwan Drug Relief Foundation, Taipei, Taiwan.

The drug injury relief system in Taiwan was implemented 20 years ago, with the goal of providing timely relief for drug injuries incurred by the proper use of legal drugs. This system utilizes a non-litigation expert review process to evaluate drug injury relief applications, and 2,732 applications have been reviewed from 1999 to 2016. Of these, 1,572 applications received relief payments, an approval rate of 58%. Read More

Br J Dermatol 2019 Apr 20. Epub 2019 Apr 20.

Urgences pédiatriques, Centre Hospitalier Universitaire Hôpital pédiatrique Lenval, Nice, France.

Background: Expert visualization of Sarcoptes scabiei remains essential for diagnosing human scabies but access to experts can be difficult. PCR is a very specific tool for the detection and confirmation of Sarcoptes scabiei but this test has a poor sensitivity because of the requirement of previous expertise when collecting appropriate samples to gain a positive result.

Objective: Evaluate PCR as a diagnostic method for scabies using non expert-dependent standardized sampling. Read More

Br J Dermatol 2019 Apr 20. Epub 2019 Apr 20.

Institute of Molecular and Cellular Anatomy, RWTH Aachen University, Aachen, Germany.

Background: Epidermal differentiation is a multi-level process in which keratinocytes need to lose their organelles including their mitochondria by autophagy. Disturbed autophagy leads to thickening of the epidermis as it is encountered in Pachyonychia congenita, a rare skin disease caused by mutations in keratins 6, 16, and 17.

Objectives: We therefore asked if mitophagy is disturbed in Pachyonychia congenita and if so at which stage. Read More

Exp Physiol 2019 Apr 20. Epub 2019 Apr 20.

Department of Kinesiology, The Pennsylvania State University, University Park, PA, 16802.

New Findings: What are the central questions of this study? Are UVR-induced increases in skin blood flow independent of skin erythema? Does broad-spectrum UVR exposure attenuate NO-mediated cutaneous vasodilation, and does sunscreen or sweat modulate this response? What are the main findings and their importance? Erythema and vascular responses to UVR are temporally distinct, and sunscreen prevents both responses. UVR exposure attenuates NO-mediated vasodilation in the cutaneous microvasculature; sunscreen or simulated sweat on the skin attenuate this response. Sun over-exposure may elicit deleterious effects on human skin that are separate from sunburn, and sunscreen or sweat on the skin may provide protection. Read More

J Eur Acad Dermatol Venereol 2019 Apr 20. Epub 2019 Apr 20.

Department of Dermatology, Venereology, Leprology, Post Graduate Institute of Medical Education and Research, Sector 12Chandigarh, India.

Background: Leprosy is a chronic granulomatous infection with varied clinical presentations. In this study, we aimed to describe the dermatoscopic features of the entire spectrum of leprosy and to correlate with clinical and histopathological findings.

Methodology: This was a prospective observational study of treatment naïve leprosy patients over a period of 1 year. Read More

J Biomed Mater Res A 2019 Apr 20. Epub 2019 Apr 20.

ISMAC/CNR, Institute for Macromolecular Studies - Consiglio Nazionale delle Ricerche, C.so G. Pella 16, Biella, Italy.

The use of bioactive proteins such as keratin has been successfully explored to improve the biological interface of scaffolds with cells during the tissue regeneration. In this work, it is optimized the fabrication of nanofibers combining wool keratin extracted by sulfitolysis, with polycaprolactone (PCL) in order to design bicomponent fibrous matrices able to exert a self-adapting pattern of signals - morphological, chemical or physical - confined at the single fiber level, to influence cell and bacteria interactions. It is demonstrated that the blending of highly polydisperse keratin with PCL (50:50) improves the stability of the electrospinning process, promoting the formation of nanofibers - 144. Read More

Mil Med 2019 Apr 20. Epub 2019 Apr 20.

Department of Anesthesia, Brooke Army Medical Center, 3551 Rodger Brooke Dr, Ft Sam Houston, TX 78234.

We present a case of a 66-year-old female who was to undergo a scheduled operation and placed on our institution's ERAS (Enhanced Recovery After Surgery) protocol. The intraoperative course was unremarkable. The patient developed delayed emergence in the Post-Anesthesia Care Unit. Read More

AAPS PharmSciTech 2019 Apr 19;20(5):169. Epub 2019 Apr 19.

Division of Pharmaceutics, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.

The aim of the present study was to explore the therapeutic efficacy of microemulsion-based delivery of histidine-capped silver nanoparticles in eradicating Klebsiella pneumoniae-induced burn wound infection. The developed microemulsion was characterized on the basis of differential light scattering, phase separation, refractive index, and specific conductance. Emulgel was prepared and characterized on the basis of thixotropy, texture, differential scanning calorimetry, and release kinetics. Read More

AAPS PharmSciTech 2019 Apr 19;20(5):171. Epub 2019 Apr 19.

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr El-Ainy Street, Cairo, 11562, Egypt.

The aim of this study was to incorporate methotrexate (MTX) into ultra-permeable niosomal vesicles, containing cremophor RH40 as an edge activator (EA) and polyvinyl alcohol (PVA) as a stabilizer to enhance the drug permeation. Formulae were prepared by ethanol injection method following a Box-Behnken design in order to optimize the formulation variables (EA%, stabilizer %, and sonication time). To investigate the role of both cremophor RH40 and PVA, conventional MTX niosomes and MTX niosomes containing PVA only were fabricated. Read More

Metabolomics 2019 Apr 19;15(4):65. Epub 2019 Apr 19.

Department of Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Drive, San Diego, CA, 92093, USA.

Introduction: Eicosanoids are biological lipids that serve as both activators and suppressors of inflammation. Eicosanoid pathways are implicated in synovitis and joint destruction in inflammatory arthritis, yet they might also have a protective function, underscoring the need for a comprehensive understanding of how eicosanoid pathways might be imbalanced. Until recently, sensitive and scalable methods for detecting and quantifying a high number of eicosanoids have not been available. Read More

Oecologia 2019 Apr 19. Epub 2019 Apr 19.

Department of Biodiversity Studies and Bioeducation, Faculty of Biology and Environmental Protection, University of Łódź, Banacha 1/3, 90-237, Łódź, Poland.

Elevated transmission rate of pathogens and parasites is considered one of the major costs of sociality in birds. However, greater risk of infection in colonial birds might be compensated by specific immune adaptations. Here, we predicted that nestlings raised in larger colonies should invest more in their immune function. Read More

J Biomech Eng 2019 Apr 20. Epub 2019 Apr 20.

Department of Finemechanics, Graduate School of Engineering, Tohoku University, 6-6-01 Aramaki Aoba, Sendai 980-8579, Japan.

The electrical response of the skin to mechanical stretches is reported here. The electrical potential difference across the epidermis (TEP: Transepidermal Potential) of porcine skin samples subjected to cyclic stretching was measured in situ to observe electrochemical change in epidermal tissue. In addition to a conventional method of TEP measurement for the whole of skin sample, a probe-type system with a fine-needle salt bridge was used for direct measurement of TEP at a targeted local point of the skin. Read More

Sci Rep 2019 Apr 19;9(1):6306. Epub 2019 Apr 19.

College of Sciences, Department of Mathematics, Research Group MASEP, University of Sharjah, P.O Box 27272, Sharjah, United Arab Emirates.

The major concern of current pagination is to report the doubly stratified medium subject to both magnetized and non-magnetized flow fields. For this purpose both the Newtonian and non-Newtonian liquids are considered in a double stratified medium having magnetic field interaction. To be more specific, a generally accepted rheological liquid around a cylindrical surface having constant radius embedded in magnetized doubly stratified media is taken into account. Read More

Med Sci Monit 2019 Apr 20;25:2896-2907. Epub 2019 Apr 20.

Department of Dermatology, The Affiliated Qingdao Municipal Hospital of Qingdao University, Qingdao, Shandong, China (mainland).

Worldwide, metastatic melanoma of the skin has an aggressive course with high morbidity and mortality. Therefore, an increased understanding of the pathogenesis of metastatic melanoma has gained increasing attention, including the role of epigenetic modification and competing endogenous RNA (ceRNA). This study aimed to used bioinformatics data to undertake an integrative analysis of long noncoding RNA (lncRNA), microRNA (miRNA) and mRNA expression to construct a ceRNA network in metastatic melanoma. Read More

Haematologica 2019 Apr 19. Epub 2019 Apr 19.

Division of Hematology, Mayo Clinic, Jacksonville, FL, USA;

Rosai-Dorfman disease is a rare subtype of non-Langerhans cell histiocytosis. With the last major report published in 1990, there is a paucity of contemporary data on this disease. Our objective was to report the clinicopathological features, treatments and outcomes of patients seen at a tertiary referral center. Read More

Haematologica 2019 Apr 19. Epub 2019 Apr 19.

Section of Virology, Department of Medicine, Imperial College London

Clin Cancer Res 2019 Apr 19. Epub 2019 Apr 19.

Inserm U1165, University Paris 7.

Purpose: The genesis of all cancers results from an accumulation of mutations, constitutional and/or acquired when induced by external mutagenic factors. High-speed technologies for genome sequencing have completely changed the study of disease genetics, but with limited knowledge of the functional value of most genetic changes.

Experimental Design: Here, we proposed an innovative individual approach by studying tissue samples from a young woman with an unusual association of breast cancer, polycythemia vera and rheumatoid arthritis. Read More

J Infect Chemother 2019 Apr 16. Epub 2019 Apr 16.

Department of Public Health Services, 1800 Mt Vernon Ave, Kern County, Bakersfield CA, 93306, USA. Electronic address:

We report a case of necrotizing skin infection caused by Yokenella regensburgei in an immunosuppressed patient with orthotopic liver transplantation. Initial bacterial culture identification was suggestive of Hafnia alvei. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) confirmed identification of Y. Read More

EBioMedicine 2019 Apr 16. Epub 2019 Apr 16.

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, PR China. Electronic address:

Background: A tick-borne segmented RNA virus called Jingmen tick virus (JMTV) was recently identified, variants of which were detected in a non-human primate host and fatal patients with Crimean-Congo haemorrhagic fever. We investigated its infectivity and pathogenicity for humans.

Methods: We obtained skin-biopsy, blood and serum samples from patients with tick bites, and used high-throughput sequencing, in situ hybridisation, and serologic testing to diagnose and ascertain the cases of JMTV infection. Read More

Pathology 2019 Apr 16. Epub 2019 Apr 16.

Department Haematology, Royal Hobart Hospital, Hobart, Tas, Australia.

Complement Ther Clin Pract 2019 May 31;35:126-130. Epub 2019 Jan 31.

St. John Fisher College Wegmans School of Pharmacy, 3690 East Avenue, Rochester, NY, 14618, USA.

Introduction: Many cancer patients require radiation therapy and often experience adverse effects including erythema, itching, and pain. Aloe vera has been studied for its potential use in the prevention and treatment of radiation related adverse effects as it possesses a variety of properties and is considered an antioxidant and anti-inflammatory agent. Multiple controlled trials have been performed in order to evaluate the efficacy of aloe vera for the prevention and treatment of radiation side effects. Read More

Asian Cardiovasc Thorac Ann 2019 Apr 19:218492319846733. Epub 2019 Apr 19.

Department of Thoracic Surgery, Choray Hospital, Ho Chi Minh City, Vietnam.

Background: The stability of the pectus bar is an important determinant of the success of pectus excavatum repair surgery. In practice, several different types of fixation method are in use for stabilizing pectus bars. The aim of this study was to compare the performance of the bridge fixation system with previous fixation systems for stabilizing pectus bars. Read More

Antioxidants (Basel) 2019 Apr 18;8(4). Epub 2019 Apr 18.

Department of Applied Sciences, Northumbria University, Newcastle Upon Tyne NE1 8ST, UK.

Many studies have shown evidence in support of the beneficial effects of phytochemicals in preventing chronic diseases, including cancer. Among such phytochemicals, sulphur-containing compounds (e.g. Read More

Sensors (Basel) 2019 Apr 18;19(8). Epub 2019 Apr 18.

Department of Computer Engineering, Boğaziçi University, Bebek, Istanbul 34342, Turkey.

The negative effects of mental stress on human health has been known for decades. High-level stress must be detected at early stages to prevent these negative effects. After the emergence of wearable devices that could be part of our lives, researchers have started detecting extreme stress of individuals with them during daily routines. Read More

Sensors (Basel) 2019 Apr 18;19(8). Epub 2019 Apr 18.

Department of Civil and Environmental Engineering, University of Perugia, 06125 Perugia, Italy.

Cracks in concrete structures can be indicators of important damage and may significantly affect durability. Their timely identification can be used to ensure structural safety and guide on-time maintenance operations. Structural health monitoring solutions, such as strain gauges and fiber optics systems, have been proposed for the automatic monitoring of such cracks. Read More

J Clin Med 2019 Apr 18;8(4). Epub 2019 Apr 18.

Dermatology, Hidradenitis Suppurativa Clinic, Hospital Universitario Virgen de las Nieves, Avenida de las Fuerzas Armadas 2, 18014 Granada, Spain.

Hidradenitis suppurativa (HS) is a chronic auto-inflammatory skin disease with a great impact in quality of life. However, there is little research about the impact of HS on sex life. The aims of this study are to describe the frequency of sexual distress (SD) in patients with HS and to explore potentially associated epidemiological and clinical factors. Read More

Pharmaceutics 2019 Apr 18;11(4). Epub 2019 Apr 18.

Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.

It is a high priority to develop a simple and effective delivery method for a cross-protective influenza vaccine. We investigated skin immunization by microneedle (MN) patch with human influenza split vaccine and virus-like particles containing heterologous M2 extracellular (M2e) domains (M2e5x virus-like particles (VLP)) as a cross-protective influenza vaccine candidate. Co-delivery of influenza split vaccine and M2e5x VLP to the skin by MN patch was found to confer effective protection against heterosubtypic influenza virus by preventing weight loss and reducing lung viral loads. Read More

Forensic Sci Int Genet 2019 Apr 4;41:72-82. Epub 2019 Apr 4.

Department of Genetic Identification, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands. Electronic address:

Correct identification of different human epithelial materials such as from skin, saliva and vaginal origin is relevant in forensic casework as it provides crucial information for crime reconstruction. However, the overlap in human cell type composition between these three epithelial materials provides challenges for their differentiation and identification when using previously proposed human cell biomarkers, while their microbiota composition largely differs. By using validated 16S rRNA gene massively parallel sequencing data from the Human Microbiome Project of 1636 skin, oral and vaginal samples, 50 taxonomy-independent deep learning networks were trained to classify these three tissues. Read More

Appl Radiat Isot 2019 Apr 7;148:218-224. Epub 2019 Apr 7.

Centre for Biomedical Physics, School of Healthcare and Medical Sciences, Sunway University, 47500, Bandar Sunway, Selangor, Malaysia; Department of Physics, University of Surrey, Guildford, Surrey, GU2 7XH, UK.

Study has been made of the thermoluminescence (TL) yield of various glass-based commercial kitchenware (Reko-China, Skoja-France, Godis-China, Glass Tum-Malaysia, Lodrat-France). Interest focuses on their potential for retrospective dosimetry. Use was made of aCo gamma-ray irradiator, delivering doses in the range 2-10 Gy. Read More

Int Immunopharmacol 2019 Apr 16;72:235-242. Epub 2019 Apr 16.

Department of Hand Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, The Second School of Medicine, Wenzhou Medical University, Wenzhou, China. Electronic address:

Objective: Batroxobin is a medicinal preparation extracted from the venom of the Fer-de-Lance snake, and is used to lower blood viscosity, promote blood fibrinogen decomposition, and inhibit thrombosis. This research is to investigate whether batroxobin can improve the survival of random skin flaps in a rat model.

Materials And Methods: Dorsal McFarlane flaps were harvested from 36 rats divided into two groups. Read More

Toxicol In Vitro 2019 Apr 16. Epub 2019 Apr 16.

Safety Evaluation Centre, Ecology & Quality Management Division, CSR Division, FUJIFILM Corporation, 210 Nakanuma, Minamiashigara-shi, Kanagawa, Japan.

The Amino acid Derivative Reactivity Assay (ADRA) is an in chemico alternative to animal testing for skin sensitization potential, in which measurements of multi-constituent solutions were sometimes affected by co-elution with nucleophilic reagents. So, we established a means of using fluorescence detection and verified the utility of a newly developed ADRA-fluorescence detection (ADRA-FL) test method. We tested three types of plant extracts-aloe, green tea, and licorice-and although unable to quantify nucleophilic reagents using ultraviolet detection due to co-elution of multiple components, the use of fluorescence detection enabled us to detect nucleophilic reagents selectively and predict each of the extract solutions to be sensitizers. Read More

Toxicol In Vitro 2019 Apr 16. Epub 2019 Apr 16.

Clinical Unit of Occupational Medicine, Department of Medical Sciences, University of Trieste, Via della Pietà 19, 34100 Trieste, Italy.

Dermal exposure to Aluminium nanoparticles (AlNPs) can occur in occupationally- and non occupationally exposed- population, due to the use of Al salts-based antiperspirants. No AlNPs transdermal permeation data exists. Our study investigated in vitro the permeation of 30-60 nm AlONPs dispersed in synthetic sweat (20 g/L) using excised human skin on Franz cells. Read More

J Allergy Clin Immunol Pract 2019 Apr 16. Epub 2019 Apr 16.

British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada; Division of Allergy and Immunology, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.

Background: In 2017, a clinical trial of 37 subjects demonstrated that preschool peanut oral immunotherapy (P-OIT) was safe, with predominantly mild symptoms reported and only 1 moderate reaction requiring epinephrine.

Objectives: We sought to examine whether these findings would be applicable in a real-world setting.

Methods: As part of a Canada-wide quality improvement project, academic and community allergists administered P-OIT to preschool-age children who had (1) skin prick test wheal diameter greater than or equal to 3 mm or specific IgE level greater than or equal to 0. Read More

Pharmacol Res 2019 Apr 16. Epub 2019 Apr 16.

Cancer Biology Laboratory and DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB) Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, 781039, India. Electronic address:

In spite of billions of dollars expended on cancer research every year, the incidence rate and the mortality rate due to this widespread disease has increased drastically over the last few decades. Recent reports from the World Health Organization advocate that overall global cancer burden and deaths due to cancer are expected to double by the next decade. Synthetic drugs developed as chemotherapeutics have repeatedly shown adverse side effects and development of chemoresistance. Read More

Biochim Biophys Acta Mol Cell Biol Lipids 2019 Apr 16. Epub 2019 Apr 16.

Department of Drug Delivery Technology, Cluster BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands. Electronic address:

Ex vivo regenerated stratum corneum (SC) after tape-stripping can be used as a model to study the barrier function of compromised skin. Yet, details about how close the regenerated SC model mimics the lipid properties (e.g. Read More

Int J Biol Macromol 2019 Apr 16. Epub 2019 Apr 16.

Department of Food Science and Biotechnology, Kyung Hee University, Yongin 17104, Republic of Korea; Skin Biotechnology Center, Kyung Hee University, Suwon 16229, Republic of Korea. Electronic address:

Vanadium-binding protein (VBP) was separated from the blood of the fresh sea urchin Halocynthia roretzi through (NH)SO precipitation, Diethylaminoethyl Sepharose fast-flow ion-exchange chromatography, and Sephacryl S-200 high-resolution size-exclusion chromatography. The protein size and purification yield of VBP were 27 kDa and 5.5%, respectively. Read More