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Aesthet Surg J 2020 Jul 2. Epub 2020 Jul 2.

Background: Aging skin and increased skin laxity is a prevalent concern of patients. Nonsurgical treatments, such as radiofrequency, are increasing in popularity due to decreased pain, downtime, and scarring. ThermiRF (Thermi, Irving, TX) is a subdermal radiofrequency treatment being used to tighten skin. Read More

J Burn Care Res 2020 Jul 2. Epub 2020 Jul 2.

US Army Institute of Surgical Research, JBSA Fort Sam Houston, TX.

Necrotic tissue generated by a thermal injury is typically removed via surgical debridement. However, this procedure is commonly associated with blood loss and removal of viable healthy tissue. For some patients and contexts such as extended care on the battlefield, it would be preferable to remove devitalized tissue with a non-surgical debridement agent. Read More

Colloids Surf B Biointerfaces 2020 Jun 25;194:111211. Epub 2020 Jun 25.

Department of Applied Physiology, School of Medicine, University of Miyazaki, Miyazaki, 889 1692, Japan.

Green synthesis of metal-encased nutraceutical nano-hybrids has been a target for research over the last few years. In the present investigation, we have reported temperature dependent facile synthesis of silver nanoparticles using FDA approved c phycocyanin (cPC). The cPC conjugated silver nanoparticles (AgcPCNPs) were characterized by TEM, Zeta Potential, UV-vis, XPS, FTIR, and CD Spectroscopy. Read More

Anaerobe 2020 Jun 29:102230. Epub 2020 Jun 29.

Univ Brest, Inserm, EFS, UMR, 1078, GGB, F-29200, Brest, France; Unité de Bactériologie, Pôle de Biologie-Pathologie, Centre Hospitalier Régional et Universitaire de Brest, Hôpital de la Cavale Blanche, Boulevard Tanguy Prigent, Brest, France. Electronic address:

Anaerobes form a large part of microbial communities, and have begun to be specifically studied in both healthy and pathologic contexts. Porphyromonas is one of the top ten anaerobic taxa in the microbiome (anaerobiome) in healthy subjects. However, to date, most studies focused on the deleterious role of P. Read More

Int J Biol Macromol 2020 Jun 29. Epub 2020 Jun 29.

Polimat, Grupo de Estudos em Materiais Poliméricos, Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis, SC 88040-900, Brazil. Electronic address:

The emergence of new materials with improved antibacterial, anti-inflammatory and healing properties compared to conventional wound dressings has both social and economic appeal. In this study, novel chitosan-based (CTS) membranes containing curcumin (CUR) incorporated in Pluronic (PLU) copolymers were developed and characterized to obtain suitable properties for applications as a wound healing dressing. The mechanical, thermal, swelling, wettability, release and permeation properties were evaluated by DSC, TGA, water contact angle measurements, FTIR, fluorescence and microscopic techniques. Read More

J Allergy Clin Immunol 2020 Jun 29. Epub 2020 Jun 29.

Department of Pediatrics, National Jewish Health, 1400 Jackson St, Denver, CO 80206; Department of Pediatrics, University of Colorado, 12700 E 19(th) Pl, Denver, CO 80045. Electronic address:

Background: The nonlesional skin of atopic dermatitis (AD) children with peanut allergy (PA) is associated with increased transepidermal water loss (TEWL), low urocanic (UCA) and pyroglutamic (PCA) acids (filaggrin [FLG] breakdown products), and reduced ratio of esterified ω-hydroxy fatty acid sphingosine ceramides (EOS-CER) to non-hydroxy fatty acid sphingosine ceramides (NS-CER) in the skin. The skin barrier of PA without AD (AD-PA+) subjects has not been studied.

Objective: To explore whether AD-PA+ is associated with skin barrier abnormalities. Read More

J Allergy Clin Immunol 2020 Jun 29. Epub 2020 Jun 29.

Department of Dermatology, Venereology, and Allergology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

Background: Skin transcriptome studies in atopic dermatitis (AD) showed broad dysregulation as well as "improvement" under therapy. These observations were mainly made in trials and based on microarray data.

Objectives: To explore the skin transcriptome and the impact of systemic treatment in patients of the TREATgermany registry. Read More

J Invest Dermatol 2020 Jun 29. Epub 2020 Jun 29.

Statistical Genetics Lab, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston QLD 4006, Australia; School of Biomedical Sciences, Faculty of Health, and Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove QLD 4059, Australia.

Organ transplant recipients (OTRs) have an elevated risk for keratinocyte cancers (KC); basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). We assessed whether polygenic risk scores (PRSs) generated in non-transplantees from the UK Biobank and 23andMe (13,981 SCC, 33,736 BCC, and >560,000 controls), can predict KC risk in an independent OTR cohort. After adjusting for traditional risk factors, compared to the bottom 20%, OTRs in the top 20% PRS had an increased risk of BCC (OR = 3. Read More

J Invest Dermatol 2020 Jun 29. Epub 2020 Jun 29.

Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD. Electronic address:

Mechanisms explaining the link between psoriasis, a pro-inflammatory condition, and cardiovascular disease (CVD) are not fully known. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is predominantly expressed in hepatocytes as a critical regulator of lipid metabolism and clinical trials targeting PCSK9 reduce CVD. Independent of its role in lipid metabolism, PCSK9 levels associate with endothelial dysfunction and predict CV events. Read More

J Plast Surg Hand Surg 2020 Jul 2:1-8. Epub 2020 Jul 2.

Division of Plastic Surgery, Zhongshan Hospital Xiamen University, Xiamen, PR China.

Nanofat grafting is a fat transfer procedure that uses a thin needle to smooth out wrinkles, thereby achieving the goal of skin rejuvenation. The Luer-Lok connector is one of the most common methods for obtaining Nanofat. In the present study, we compared three different Luer-Lok connectors (2. Read More

Mol Oncol 2020 Jul 2. Epub 2020 Jul 2.

Department of Biosciences, Cancer Cluster Salzburg, Paris-Lodron University Salzburg, Salzburg, Austria.

Genetic activation of Hedgehog (HH)/GLI signaling causes basal cell carcinoma (BCC), a very frequent non-melanoma skin cancer. Small molecule targeting of the essential HH effector Smoothened (SMO) has proven an effective therapy of BCC, though the frequent development of drug resistance poses major challenges to anti-HH treatments. In light of recent breakthroughs in cancer immunotherapy, we analyzed the possible immunosuppressive mechanisms in HH/GLI-induced BCC in detail. Read More

J Forensic Sci 2020 Jul 2. Epub 2020 Jul 2.

Department of Chemical Sciences, University of Padova, via Marzolo 1, Padova, 35131, Italy.

DNA analysis has been widely used in the forensic field in order to contribute to identifying the perpetrator of a crime. Forensic investigation in sexual assaults usually focuses on locating and identifying biological fluids, followed by DNA analysis. The identification of certain compounds present in condoms can be useful to reconstruct the occurred event, especially in cases of sexual assaults where the DNA analysis did not show the presence of a male profile and where RNA analysis did not show the presence of sperm markers. Read More

Exp Dermatol 2020 Jul 2. Epub 2020 Jul 2.

Laboratory of Investigative Dermatology, Rockefeller University, New York, United States.

Background: Hidradenitis Suppurativa (HS), also known as acne inversa, is a chronic inflammatory skin disease with still largely unknown pathogenesis. While infectious organisms have been identified in lesions of the disease since the 1980s, questions remain over the role that bacteria and microbiome play. Recent studies using 16S ribosomal RNA genesequencing and larger culture-based studies have begun to paint a clearer picture of the microbial world of HS. Read More

Dermatol Ther 2020 Jul 2:e13944. Epub 2020 Jul 2.

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, THAILAND.

Background: Intradermal injection of botulinumtoxinA (BoNT/A) has been used off-label by many clinicians for the purpose of face-lifting effect. Some studies on AbobotulinumtoxinA (AboA) demonstrated clinical efficacy on face-lifting effect when comparing to normal saline solution (NSS). So far, there is no split-face comparison study on face-lifting effect of IncobotulinumtoxinA (IncoA). Read More

Photochem Photobiol 2020 Jul 2. Epub 2020 Jul 2.

Depto. de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brazil.

Sunlight ultraviolet (UV) radiation constitutes an important environmental genotoxic agent that organisms are exposed to, as it can damage DNA directly, generating pyrimidine dimers, and indirectly, generating oxidized bases and single-strand breaks (SSBs). These lesions can lead to mutations, triggering skin and eye disorders, including carcinogenesis and photoaging. Stratospheric ozone layer depletion, particularly in the Antarctic continent, predicts an uncertain scenario of UV incidence on the Earth in the next decades. Read More

PLoS One 2020 2;15(7):e0235288. Epub 2020 Jul 2.

Sackler Institute of Comparative Genomics, American Museum of Natural History, Manhattan, New York, United States of America.

The American crocodile (Crocodylus acutus) is a widely distributed species across coastal and brackish areas of the Neotropical region of the Americas and the Greater Antilles. Available information on patterns of genetic differentiation in C. acutus shows a complex structuring influenced by interspecific interactions (mainly hybridization) and anthropogenic actions (mostly historical hunting, recent poaching, habitat loss and fragmentation, and unintentional translocation of individuals). Read More

PLoS One 2020 2;15(7):e0235261. Epub 2020 Jul 2.

Department of Medicine, University of California San Francisco, San Francisco, California, United States of America.

Background: Tuberculosis (TB) is the leading cause of death among people living with HIV (PLWH), and current evidence suggests that heavy alcohol users have an increased risk of developing TB disease compared to non-drinkers. Not known is whether the increased risk for TB disease among alcohol users may reflect higher rates of latent TB infection (LTBI) among this population. We assessed the latent TB infection prevalence based on tuberculin skin testing (TST) and examined association with current alcohol use among HIV-infected persons on antiretroviral therapy (ART) in south-western Uganda. Read More

PLoS One 2020 2;15(7):e0234792. Epub 2020 Jul 2.

Division of Research, Philadelphia College of Osteopathic Medicine, Philadelphia, PA, United States of America.

The Myo/Nog cell lineage was discovered in the chick embryo and is also present in adult mammalian tissues. The cells are named for their expression of mRNA for the skeletal muscle specific transcription factor MyoD and bone morphogenetic protein inhibitor Noggin. A third marker for Myo/Nog cells is the cell surface molecule recognized by the G8 monoclonal antibody (mAb). Read More

PLoS Negl Trop Dis 2020 Jul 2;14(7):e0008221. Epub 2020 Jul 2.

Infectious Disease Research Laboratory, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.

Leishmaniasis remains a public health concern around the world that primarily affects poor folks of the developing world spanning across 98 countries with mortality of 0.2 million to 0.4 million annually. Read More

J Infect Dev Ctries 2020 Jun 29;14(6.1):36S-41S. Epub 2020 Jun 29.

UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR), World Health Organization, Geneva, Switzerland.

Introduction: In 2017, Ethiopia included scabies management within the responsibility of health extension workers. In Kamba (the intervention district) workers were trained on scabies management. Whereas, in Arba Minch Zuria (the control district) there was no such training. Read More

J Infect Dev Ctries 2020 Jun 29;14(6.1):22S-27S. Epub 2020 Jun 29.

UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR), World Health Organization, Geneva, Switzerland.

Introduction: Endemic non-filarial elephantiasis also known as podoconiosis often affects bare footed farmers and is endemic in Ethiopia. The disease is prevented by wearing shoes. We recently observed several patients presenting to a dermatology clinic with skin depigmentation after wearing plastic shoes ("shoe-contact vitiligo") which may deter shoe-wearing. Read More

J Infect Dev Ctries 2020 Jun 29;14(6.1):16S-21S. Epub 2020 Jun 29.

Institute of Tropical Medicine, Antwerp, Belgium.

Introduction: The majority of neglected tropical diseases (NTDs) have established primary skin manifestations or associated clinical feature. Skin NTDs often result in physical impairment and disfigurement, which can lead to disability. Skin diseases have been proposed as an entry point for integrated NTDs control. Read More

J Appl Clin Med Phys 2020 Jul 2. Epub 2020 Jul 2.

Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Purpose: To evaluate the dosimetric effects of the AeroForm (AirXanpders®, Palo Alto, CA) tissue expander in-situ for breast cancer patients receiving post-mastectomy radiation therapy.

Methods And Materials: A film phantom (P1) was constructed by placing the metallic canister of the AeroForm on a solid water phantom with EBT3 films at five depths ranging from 2.6 mm to 66. Read More

J Biochem Mol Toxicol 2020 Jul 2:e22566. Epub 2020 Jul 2.

Department of Biotechnology, Faculty of Science, Bartin University, Bartin, Turkey.

Tyrosinase enzyme is a functional oxidase that is extensively divided in nature. It is the main enzyme in melanin synthesis and is also involved in designating the color of mammalian hair and skin. Additionally, it is accountable for the unfavorable enzymatic browning that happens in plant-derived foods, limiting the shelf-life of new-cut crops with the resultant economic harm. Read More

J Food Biochem 2020 Jul 2:e13360. Epub 2020 Jul 2.

Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.

Increased reactive oxygen species (ROS) along with inflammation are involved in the prostate cancer (PCa). Therefore, this study was conducted to investigate the molecular mechanisms that were affected by arbutin as an antioxidant on prostate cancer cell line; LNCap. The intracellular ROS measurement confirmed that arbutin significantly (p < . Read More

Genome Biol Evol 2020 Jul 2. Epub 2020 Jul 2.

Faculty of Engineering and Sciences, Universidad Adolfo Ibañez, Diagonal Las Torres 2700, Peñalolén, Santiago, Chile.

Detection of positive selection signatures in populations around the world is helping to uncover recent human evolutionary history as well as the genetic basis of diseases. Most human evolutionary genomic studies have been performed in European, African and Asian populations. However, populations with Native American ancestry have been largely underrepresented. Read More

JAMA Netw Open 2020 Jul 1;3(7):e207221. Epub 2020 Jul 1.

Research Institute of Radiology, Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Importance: Occult spinal dysraphism (OSD) is the most common congenital spinal anomaly. Cutaneous anomalies such as skin dimples or deviated gluteal folds are well known as stigmata of OSD and are indicators for further evaluation; however, the association between cutaneous anomalies and OSD has not been systemically evaluated.

Objective: To evaluate the incidence of OSD and the proportion of OSD cases managed with a neurosurgical intervention among neonates or infants with various cutaneous stigmata. Read More

Clin Ter 2020 Jul-Aug;171(4):e310-e315

Dermatology Unit "D. Innocenzi", Polo Pontino, Sapienza University of Rome, Rome, Italy.

Background: Psoriasis is a multifactorial chronic inflammatory skin disease characterized by erythemato-squamous lesions with a chronic relapsing course. The desease clinical activity (PASI) and the patient's quality of life (DLQI) are the main elements to assess for setting up a correct therapeutic management.

Objectives: The aim of the study was to evaluate the management of the patient with moderate-severe psoriasis in therapy with biological drugs and to establish the difference in the achievement of PASI 90 and DLQI 0-1 between a group of patients treated with only biological drugs and a group of patients receiving biologic therapy in combination with a topical ointment. Read More

Clin Ter 2020 Jul-Aug;171(4):e302-e303

Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Rome.

Forensic pathology is the scientific branch which, more than every other, today draws from new technologies inherent to other medical fields. In the last century history of forensic pathology has been characterized by a necessary conjunction between tradition and innovation, which primary achievement is finding the truth and scientific objectivity. During the past centuries several studies have enriched scientific forensic panorama, until the most recent introductions in radiological fields (3D post-mortal CT and MRI) and in the molecular biological one, with disclosure of miRNA. Read More

Dis Aquat Organ 2020 Jul 2;140:47-54. Epub 2020 Jul 2.

Institute of Aquaculture, Faculty of Natural Sciences, University of Stirling, Stirling FK9 4LA, UK.

Healthy and/or moribund farmed and wild ballan wrasse Labrus bergylta (>0.5 to 900 g) were sampled from hatcheries (n = 2) and Atlantic salmon Salmo salar cage sites (n = 8) in Scotland between February 2016 and October 2018. Less than half of the sampled individuals (n = 43; 32. Read More

Wound Manag Prev 2020 Jul;66(7):33-38

Division of Plastic Surgery, University of Mississippi Medical Center, Jackson, Mississippi.

Os styloideum is an accessory wrist bone at the base of the second and third metacarpals. Similar to metacarpal bossing, chronic pain secondary to the development of osteoarthritis and tendon irritation is common. Conservative management consists of splinting and steroid injections, with surgical resection being the definitive treatment. Read More

Med Sci (Paris) 2020 Jun-Jul;36(6-7):565-568. Epub 2020 Jul 2.

Laboratoire de génomique et radiobiologie de la kératinopoïèse, CEA/DRF/IBFJ/IRCM, 2 rue Gaston Crémieux, 91000 Évry, France Inserm U967, Fontenay-aux-Roses ; Université Paris-Diderot, Université Paris-Saclay, France.

ACS Appl Mater Interfaces 2020 Jul 2. Epub 2020 Jul 2.

Stretchable and conductive hydrogels have been intensively studied as wearable electronics to monitor the physiological activities of human bodies. However, it remains a challenge to fabricate robust hydrogels as sensors with complex 3D structures. Here, we designed a 3D printable ink from cellulose nanocrystals (CNCs), deep eutectic solvents (DESs) and ionically cross-linked polyacrylic acid (PAA). Read More

J Cosmet Dermatol 2020 Jul 2. Epub 2020 Jul 2.

Gregory Keller Plastic Surgery, Santa Barbara, California.

Background: Defensins are peptides shown to activate LGR6 stem cells to stimulate the production of new basal stem cells in the epidermis. Use of topical definsin-containing products has been shown to address signs of global skin aging including decrease of wrinkles and increase of epidermal thickness.

Aims: To investigate the ability of a topical defensin-containing skincare product in improving the structure and function of aging periocular skin using objective and subjective outcome measures. Read More

Dermatol Ther 2020 Jul 2:e13951. Epub 2020 Jul 2.

Department of Dermatology - Centre Hospitalier Universitaire de Nancy, Nancy, France.

Dermatol Ther 2020 Jul 2:e13949. Epub 2020 Jul 2.

School of Medicine, Department of Dermatology and Venereology, Uşak University, Turkey.

Many areas of life including patterns of dermatological diseases that patient attend to the hospital were tremendously affected by implementing stay-at-home orders during the COVID-19 pandemic. We aimed to identify the dermatologic interest of the public during the COVID-19 pandemic by using Google Trends. The terms "acne", "hair loss", "eczema", "genital warts", "molluscum contagiosum", "botox", "skin cancer", "sunscreen" were analyzed on first April, first May, first June 2020, and the corresponding period of the previous year in Turkey and Italy by using Google Trends. Read More

Lasers Surg Med 2020 Jul 2. Epub 2020 Jul 2.

Biomedical Laser and Optics Group, Department of Biomedical Engineering, University of Basel, Gewerbestrasse 14, Allschwil, 4123, Switzerland.

Background And Objectives: Using lasers instead of mechanical tools for bone cutting holds many advantages, including functional cuts, contactless interaction, and faster wound healing. To fully exploit the benefits of lasers over conventional mechanical tools, a real-time feedback to classify tissue is proposed.

Study Design/materials And Methods: In this paper, we simultaneously classified five tissue types-hard and soft bone, muscle, fat, and skin from five proximal and distal fresh porcine femurs-based on the laser-induced acoustic shock waves (ASWs) generated. Read More

Radiat Prot Dosimetry 2020 Jul;188(4):508-515

School of Electrical Engineering, University of Belgrade, Studentski trg 1, 11000 Belgrade, Serbia.

Numerous cases of radiation-induced tissue reactions following interventional cardiology (IC) procedures have been reported, resulting in the need for an optimized and personalized dosimetry. At present, there are many fluoroscopy units without Digital Imaging and Communications in Medicine (DICOM) Radiation Dose Structured Report globally installed. Many of these have not been updated yet, and may never be, therefore, the main objectives of this paper are to develop an offline skin dose mapping application, which uses DICOM headers for the peak skin dose (PSD) assessment and to compare the PSD assessment results to XR-RV3 Gafchromic film for common IC procedures. Read More

Food Funct 2020 Jul 2. Epub 2020 Jul 2.

Plants for Human Health Institute, North Carolina State University, Kannapolis, NC, USA. and Department of Food Bioprocessing and Nutrition Sciences, North Carolina State University, Raleigh, NC, USA.

Juicing of grapes includes contact with phenolic rich seeds and skins that otherwise rely on maceration for phenolic release. To understand if 100% grape juice can provide a matrix with highly bioaccessible phenolics relative to whole fruit, differences in phenolic content and bioaccessibility from commonly consumed table, Concord (CG) and Niagara (NG) grapes and their 100% juices were compared. Phenolic contents in whole grapes and 100% juices were assayed by LC-MS prior to in vitro digestion to determine phenolic bioaccessibility. Read More

Immunol Invest 2020 Jul 2:1-9. Epub 2020 Jul 2.

Department of Laboratory Medicine, Huangyan Hospital of Wenzhou Medical University, Taizhou First People's Hospital , Taizhou, Zhejiang, China.

Interleukin-31 (IL-31) has diverse biological functions. Increased IL-31 has been found in some skin and autoimmune diseases. There has been no study reporting the association between IL-31 and primary biliary cholangitis (PBC). Read More

Clin Nurs Res 2020 Jul 2:1054773820937479. Epub 2020 Jul 2.

Department of Pediatric Nursing, Faculty of Health Sciences, Fırat University, Elazığ, Turkey.

The aim of this study was to investigate the emotions and experiences of fathers in Eastern Anatolia Region of Turkey who applied kangaroo care in the neonatal intensive care unit. This study applied the qualitative descriptive design. The study included 12 fathers at the NICU of a university hospital. Read More

ACS Appl Mater Interfaces 2020 Jul 2. Epub 2020 Jul 2.

We propose an integrated, self-powered, flexible electronic skin device containing an alginate-derived polymer dot (A-PD)-incorporated mineralized hydrogel-based energy-storage unit and a chitosan-derived n-type carbon dot (N-CD)-based solar cell for an energy-harvesting unit. This study demonstrates a unique architecture of mineralized hydrogel comprising of A-PD-incorporated poly(acrylic acid) (PAA)/CaCO3/laponite containing soft and sensitive layer, deposited with a polyaniline electrode to serve as an energy storage unit. The self-assembly was achieved through the ionic crosslinking between A-PD and PAA driven by the mineralization process, resulting in excellent dimensional stability and improved mechanical properties of the hydrogel. Read More

ACS Appl Mater Interfaces 2020 Jul 2. Epub 2020 Jul 2.

Department of Biomedical Sciences, City University of Hong Kong, Hong Kong 999077, P. R. China.

Wound-associated infections create additional suffering and come at a high cost for patients and their families, which urgently require wound disinfection biomaterials with improved healing efficacy. Here, we report an adhesive with sustained bacteria disinfection ability, which is aggregated from hydrogen-bonded polymer particulates. The particulate-aggregated adhesive shows strong binding ability on different surfaces from rigid substrates to soft skins. Read More

J Dermatol 2020 Jul 1. Epub 2020 Jul 1.

Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

High-mobility group box 1 (HMGB-1) is a highly abundant pro-inflammatory protein associated with the pathogenesis of inflammatory and autoimmune diseases. HMGB-1 expression level increases in patients with psoriasis vulgaris (PV). However, HMGB-1 expression in patients with generalized pustular psoriasis (GPP) is unknown. Read More

Ann Clin Transl Neurol 2020 Jul 2. Epub 2020 Jul 2.

Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, No.58 Zhongshan Road 2, Guangzhou, 510080, China.

Patients with combined phenotypes of Sturge-Weber syndrome and Klippel-Trenaunay syndrome have been reported, though the underlying genetic spectrum in these individuals remains to be elucidated. We reported the patient presenting with Klippel-Trenaunay and Sturge-Weber overlap syndrome in mainland China. Histopathologic study confirmed the hemangioma of vein and capillary. Read More

J Cosmet Dermatol 2020 Jul 2. Epub 2020 Jul 2.

D.I.V.A. Expertise, Toulouse, France.

Background: Purple tulip extract is a rich source of flavonoids which are powerful antioxidants and can hence be considered as an ideal candidate for use in skin care products.

Objectives: We aimed to evaluate the effects of purple tulip extract on skin quality and to determine its molecular modes of interaction.

Methods: A pangenomic study on human skin fibroblasts was carried out to analyse multiple changes in gene expression. Read More

Br J Dermatol 2020 Jul;183(1):1-2

Faculty of Life Sciences & Medicine, Kings College London, London, SE1 9RT, UK.

Br J Dermatol 2020 Jul;183(1):e4-e30

Atopic dermatitis (AD), a long-lasting skin disease characterized by intense itching and dry, red, swollen and cracked skin, affects between 2% and 10% of Japanese adults. In Japan, patients with moderate-to-severe or very severe AD have limited treatment options, most with unwanted side effects. There is a need for therapies that provide safe and effective long-term control. Read More

Br J Dermatol 2020 Jul 1. Epub 2020 Jul 1.

COVID Emergency Task Force, XXIII Children Hospital, Azienda Ospedaliero Universitaria consorziale Policlinico, Giovanni, Piazza G. Cesare 11, 70124, Bari, Italy.

Despite its aggressive clinical course, leading to 6.4% fatality rate as of May 25, 2020 (https://qap.ecdc. Read More

Br J Dermatol 2020 Jul 1. Epub 2020 Jul 1.

Division of Dermatology, Santa Chiara Hospital, Trento, Italy.

The outbreak of chilblain-like lesions (CLL) coincidentally to the COVID-19 pandemic is a topic of great concern. SARS-CoV-2 has been hypothesized as the etiologic agent of CLL, on the basis of the temporal correlation between the "burst" of skin manifestations and the viral pandemic. However, the relationship between CLL and COVID-19 remains unclear, since authors failed to confirm the SARS-CoV-2 infection in these patients using a real-time reverse transcription polymerase chain reaction (rt-PCR) test from nasopharyngeal swabs, which seldom resulted positive. Read More