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J Ayurveda Integr Med 2022 Jun 24;13(3):100583. Epub 2022 Jun 24.

Department of Biochemistry, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. Electronic address:

Background: Ayurveda is a holistic system of medicine and describes a vast array of herbs and herbal mixtures that are been demonstrated to possess efficacy in research investigations. Guggulutikthaka gritha (GTG) is one such drug evaluated for its role in skin and bone diseases.

Objective: In the current study, the hypoglycemic, hypolipidemic, and anti-inflammatory effect of the drug GTG was studied with the scope to treat dyslipidemia and thereby reduce the risk of cardiovascular disease. Read More

Anat Histol Embryol 2022 Jun 27. Epub 2022 Jun 27.

Department of Dermatology, University of California, San Francisco and Veterans Affairs Health Care System, San Francisco, California, USA.

Cetacean skin continues to be the investigative focus of researchers from several different scientific disciplines. Yet, most research on the basic functions of lipo-keratinocytes, which constitute most of the cetacean epidermis, providing the first layer of protection against various environmental aggressors (including an ever-increasing level of pollutants), is restricted to specialized literature on the permeability barrier only. In this review, we have attempted to bring together much of the recent research on the functional biology of cetacean skin, including special adaptations at the cellular, genetic and molecular level. Read More

Neurobiol Pain 2022 Aug-Dec;12:100097. Epub 2022 Jun 17.

Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS, United States.

Spinal cord injury (SCI) is a complex syndrome that has profound effects on patient well-being, including the development of medically-resistant chronic pain. The mechanisms underlying SCI pain have been the subject of thorough investigation but remain poorly understood. While the majority of the research has focused on changes occurring within and surrounding the site of injury in the spinal cord, there is now a consensus that alterations within the peripheral nervous system, namely sensitization of nociceptors, contribute to the development and maintenance of chronic SCI pain. Read More

Front Genet 2022 8;13:894716. Epub 2022 Jun 8.

Department of Ultrasound and Imaging, Wenzhou Central Hospital, Wenzhou, China.

As an important means of physical examination, palpation is usually limited to the physical examination before surgery and used as an auxiliary method for disease diagnosis in the field of surgery. In practice, palpation is also used in every aspect of the surgical procedure, and its application is of great significance to surgery. The purpose of this study was to investigate the ability of ultrasound imaging to assess the ability of rotating physicians to locate musculoskeletal structures by palpation. Read More

Folia Morphol (Warsz) 2022 Jun 27. Epub 2022 Jun 27.

Anatomy and Embryology Department, Faculty of Medicine, Ain Shams University, Egypt.

Background: Microvesicles (MVs) derived from mesenchymal stem cells exhibited an emerging promising therapy in many animal model diseases. Post-burn scars represent one of the significant challenges in wound healing processes. The present study investigated the possible role of MVs derived from mesenchymal stem cells versus platelet-rich plasma (PRP) in murine burn wound healing. Read More

Biochimie 2022 Jun 22. Epub 2022 Jun 22.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, I.R. Iran. Electronic address:

Combination chemotherapy seems to be a beneficial choice for some cancer patients particularly when the drugs target different processes of oncogenesis; patients treated with combination therapies sometimes have a better prognosis than those treated with single drug chemotherapy. However, research has shown that this is not always the case, and this approach may only increase toxicity without having a significant effect in augmenting the antitumor actions of the drugs. Doxorubicin (Dox) is one of the most common chemotherapy drugs used to treat many types of cancer, but it also has serious side effects, such as cardiotoxicity, skin necrosis, testicular toxicity, and nephrotoxicity. Read More

Facial Plast Surg 2022 Jun 25. Epub 2022 Jun 25.

Plastic Surgery, Plastic Surgery, Thessaloniki, Greece.

There is a need for a specialist pathway or progression in aesthetic medicine for aesthetic physicians. A structured program for specialised training in non-surgical facial aesthetics to empower physicians is the need of the hour. The pharmaceutical companies currently provide training sessions, taking considerable initiatives to train aesthetic professionals. Read More

Otolaryngol Clin North Am 2022 Jun 21. Epub 2022 Jun 21.

Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology- Head and Neck Surgery, University of California San Francisco, 2233 Post Street, 3rd Floor, San Francisco, CA 94115, USA. Electronic address:

The face is central to individual identity and gender presentation. Sex-based differences are seen at nearly every component of the face, from craniofacial structure to skin and soft tissue distribution. This article provides a framework for identification and analysis of sex-based differences in facial anatomy. Read More

Otolaryngol Clin North Am 2022 Jun 21. Epub 2022 Jun 21.

Private Practice; Department of Otolaryngology-Head and Neck Surgery, University of Texas Medical Branch, Galveston, TX, USA. Electronic address:

The perioral area can be an important feature to convey femininity, particularly when speaking and smiling. A feminine lip has a shorter distance between the nasal sill and the vermillion border, fullness of the vermillion, and a few millimeters of tooth show with the mouth slightly open. The keys to a good outcome are incision design that respects the natural anatomy, placing the tension of the lift deep to the dermis to take tension off of the skin incision, determining the appropriate amount of lift for the patient's anatomy, and not violating the orbicularis oris. Read More

Actas Dermosifiliogr 2022 Jun 26;113(6):T632-T635. Epub 2022 Apr 26.

Departamento de Anatomía Patológica, Hospital Universitari General de Catalunya, Sant Cugat del Vallès, Spain.

Actas Dermosifiliogr 2022 Jun 11;113(6):T575-T582. Epub 2022 May 11.

Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, Spain.

Familiarity with predictors of more aggressive behavior is crucial to the management of basal cell carcinoma (BCC). Risk factors for aggressive BCC are essentially divided into clinical and histopathologic factors. In this review we examine histopathologic features predictive of aggressiveness in BCC. Read More

Pharmaceuticals (Basel) 2022 May 25;15(6). Epub 2022 May 25.

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Sinai University, Kantra 41636, Egypt.

To achieve the best treatment of skin cancer, drug penetration inside the deepest layers of the skin is an important scientific interest. We designed an ethosome formulation that serves as a carrier for metformin and measured the in vitro skin permeation. We also aimed to measure the antitumor activity of the optimal ethosomal preparation when applied topically to chemically induced skin cancer in mice. Read More

Nutrients 2022 Jun 12;14(12). Epub 2022 Jun 12.

Department of Herbal Pharmacology, College of Korean Medicine, Gachon University, 1342 Seongnamdae-ro, Sujeong-gu, Seongnam 13120, Korea.

Psoriasis is an inflammatory autoimmune skin disease with various clinical manifestations. The aim of this review was to systematically evaluate the efficacy and safety of oral administration of East Asian herbal medicine (EAHM) for inflammatory skin lesions in psoriasis and to explore core herbal materials for drug discovery. A comprehensive search was conducted in 10 electronic databases for randomized controlled trials from their inception until 29 July 2021. Read More

Nutrients 2022 Jun 10;14(12). Epub 2022 Jun 10.

Food and Mood Centre, IMPACT-The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Deakin University, Geelong, VIC 3220, Australia.

Advanced glycation end products (AGEs) are glycated proteins or lipids formed endogenously in the human body or consumed through diet. Ultra-processed foods and some culinary techniques, such as dry cooking methods, represent the main sources and drivers of dietary AGEs. Tissue accumulation of AGEs has been associated with cellular aging and implicated in various age-related diseases, including type-2 diabetes and cardiovascular disease. Read More

Int J Mol Sci 2022 Jun 19;23(12). Epub 2022 Jun 19.

Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, Tokyo 113-8603, Japan.

Keloids and hypertrophic scars are pathological cutaneous scars. They arise from excessive wound healing, which induces chronic dermal inflammation and results in overwhelming fibroblast production of extracellular matrix. Their etiology is unclear. Read More

Int J Mol Sci 2022 Jun 10;23(12). Epub 2022 Jun 10.

Biohellenika Biotechnology Company, Leoforos Georgikis Scholis 65, 55535 Thessaloniki, Greece.

Syndecans act as independent co-receptors to exert biological activities and their altered function is associated with many pathophysiological conditions. Here, syndecan-1 and -4 were examined in lesional skin of patients with psoriasis. Immunohistochemical staining confirmed altered syndecan-1 distribution and revealed absence of syndecan-4 expression in the epidermis. Read More

Int J Mol Sci 2022 Jun 10;23(12). Epub 2022 Jun 10.

Department of Clinical and Experimental Medicine, School and Operative Unit of Allergy and Clinical Immunology, University of Messina, 98125 Messina, Italy.

Interleukin 31 belongs to the IL-6 superfamily, and it is an itch mediator already studied in several diseases, comprising atopic dermatitis, allergic pathologies, and onco-hematological conditions. This research aims to assess the role of this cytokine in the pathogenesis of these conditions and its potential therapeutic role. The research has been conducted on articles, excluding reviews and meta-analysis, both on animals and humans. Read More

Int J Mol Sci 2022 Jun 10;23(12). Epub 2022 Jun 10.

Department of Animal Molecular Biology, National Research Institute of Animal Production, Krakowska 1 Street, Balice, 32-083 Kraków, Poland.

An important component of tissues is the extracellular matrix (ECM), which not only forms a tissue scaffold, but also provides the environment for numerous biochemical reactions. Its composition is strictly regulated, and any irregularities can result in the development of many diseases, including cancer. Sarcoid is the most common skin cancer in equids. Read More

Genes (Basel) 2022 May 29;13(6). Epub 2022 May 29.

Pediatric Department, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.

Niemann-Pick disease type C (NPC) is an autosomal recessive neurovisceral disease characterized by progressive neurodegeneration with variable involvement of multisystemic abnormalities. Crohn's disease (CD) is an inflammatory bowel disease (IBD) with a multifactorial etiology influenced by variants in . Here, we investigated a patient with plausible multisystemic overlapping manifestations of both NPC and CD. Read More

Diagnostics (Basel) 2022 Jun 1;12(6). Epub 2022 Jun 1.

Department of Medical Sciences, Faculty of Health Sciences, University of Castilla-La Mancha, 45600 Talavera de la Reina, Spain.

Morton's neuroma (MN) is a common condition in clinical practice. The compressive etiology is the most accepted, in which compression occurs in the tunnel formed by the adjacent metatarsals, the deep transverse metatarsal ligament (DTML) and the plantar skin. Ultrasound (US) is a reliable method of study. Read More

Sci Rep 2022 Jun 23;12(1):10623. Epub 2022 Jun 23.

Doheny Eye Institute, Los Angeles, CA, USA.

Primary open angle glaucoma (POAG) features an optic neuropathy, elevated aqueous humor (AH) TGFβ2, and major risk factors of central corneal thickness (CCT), increasing age and intraocular pressure (IOP). We examined Tight skin (Tsk) mice to see if mutation of fibrillin-1, a repository for latent TGFβ, is associated with characteristics of human POAG. We measured: CCT by ocular coherence tomography (OCT); IOP; retinal ganglion cell (RGC) and optic nerve axon counts by microscopic techniques; visual electrophysiologic scotopic threshold responses (STR) and pattern electroretinogram (PERG); and AH TGFβ2 levels and activity by ELISA and MINK epithelial cell-based assays respectively. Read More

J Eur Acad Dermatol Venereol 2022 Jun;36 Suppl 6:38-50

Dermatology Unit, University of Campania, Naples, Italy.

The incidence of non-melanoma skin cancer is on the rise and melanoma is among the most common cancers in the United States. Establishing an early diagnosis is essential for improving the prognosis of patients with skin cancer. High-resolution non-invasive imaging techniques may represent key tools for helping to identify and monitor early signs of skin cancer in seemingly healthy skin. Read More

In Vivo 2022 Jul-Aug;36(4):1647-1650

AntiCancer Inc, San Diego, CA, U.S.A.;

Background/aim: Although the 5-year survival rate for localized prostate cancer is nearly 100%, prognosis for patients with metastases, of which the bone is the most common site, is poor. In order to evaluate efficacy of treatments against metastatic prostate cancer, experimental tibia-bone-metastasis mouse models of prostate cancer have been previously established. In the present study, we used a novel procedure for establishment of an experimental tibiabone metastasis mouse model, with human PC-3 prostate cancer expressing green fluorescent protein (GFP), that more closely matches prostate cancer growing in the bone. Read More

In Vivo 2022 Jul-Aug;36(4):1734-1744

Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.

Background/aim: Hypertrophic scars (HS) are the result of pathological wound healing characterized by a red, raised scar formation. The goal of this research was development of a new method for treatment of HS formation.

Materials And Methods: A tranilast-loaded microneedle (TMN) was developed and applied in a rabbit ear model to treat an induced HS. Read More

Proteomes 2022 Jun 1;10(2). Epub 2022 Jun 1.

Department of Microbiology, Anatomy, Physiology and Pharmacology, La Trobe University, Melbourne, VIC 3086, Australia.

Parkinson's disease is the second largest neurodegenerative disease worldwide and is caused by a combination of genetics and environment. It is characterized by the death of neurons in the substantia nigra of the brain but is not solely a disease of the brain, as it affects multiple tissues and organs. Studying Parkinson's disease in accessible tissues such as skin and blood has increased our understanding of the disease's pathogenesis. Read More

Ned Tijdschr Geneeskd 2022 May 31;166. Epub 2022 May 31.

Maastricht UMC+, afd. Dermatologie, Maastricht.

Basal cell carcinoma (BCC) is the most common cancer type in the Netherlands and frequently diagnosed in older adults. Unlike other common forms of skin cancer (squamous cell carcinoma and melanoma), BCC generally grows slowly and the risk of metastasis and/or death is extremely small. In the first years after presentation, BCC often causes no or only minor complaints. Read More

Dermatopathology (Basel) 2022 Jun 18;9(2):183-195. Epub 2022 Jun 18.

Pathology Department, Mures Clinical County Hospital, 540011 Targu Mures, Romania.

: Basal carcinoma of the skin (BCC) is part of the nonmelanoma skin cancer (NMSC) family and is the most frequently occurring type of skin cancer in humans. A combination of clinical and histopathological approaches is necessary in order to establish the best treatment regime for patients who have been diagnosed with this type of cancer. The objective of the present study was to establish the statistical value of prediction for certain sociodemographic characteristics (age category and environment of origin) and histopathological parameters of the subjects that could be related to the incidence of diagnosis with certain histopathological subtypes of BCC. Read More

Curr Oncol 2022 May 31;29(6):3933-3939. Epub 2022 May 31.

Tom Baker Cancer Center, Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N2, Canada.

NTRK gene fusions are rare oncogenic driver mutations that can be found in a broad range of neoplasms. In secretory carcinoma (SC), gene fusion is seen in a majority of the cases and represents a druggable target for patients with advanced disease in the absence of a currently accepted standard of care. In our case, we describe a patient with recurrent, metastatic SC treated with first line entrectinib with clinically meaningful, durable ongoing response after 49 months. Read More

Dis Aquat Organ 2022 Jun 23;149:133-143. Epub 2022 Jun 23.

Laboratorio de Inmunología, Facultad de Agronomía y Veterinaria, Universidad Autónoma de San Luis Potosí, S.L.P., CP 78399, Mexico.

Fibropapillomatosis (FP) is a tumor disease that affects all sea turtle species but is mainly seen in green turtles Chelonia mydas. The pathology of FP has been described extensively, but its dynamics in populations over time have been less studied. We analyzed the dynamics of FP in a population of green turtles in Akumal Bay on the central coast of the Mexican Caribbean. Read More

Biomarkers 2022 Jun 23:1-14. Epub 2022 Jun 23.

Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Egypt; (A.M.M.).

Burn injuries are underappreciated injuries that cause significant morbidity and mortality. Burn injuries, especially severe burns, trigger immunological and inflammatory responses, metabolic abnormalities, and distributive shock, all of which can be extended to multiple organ failures. () has been exploited for its medicinal properties for centuries. Read More