277,001 results match your criteria Skin Anatomy


Dermal papillae flattening of thigh skin in Syndrome.

Eur J Transl Myol 2018 Nov 13;28(4):7914. Epub 2018 Dec 13.

Interdepartmental Research Center of Myology, Department of Neuroscience, Section of Human Anatomy, University of Padova, Italy.

Our previous studies have shown that severely atrophic Quadriceps muscles of spinal cord injury (SCI) persons suffering with complete and syndrome, and thus with permanent denervation-induced atrophy and degeneration of muscle, were almost completely rescued to normal size after two years of home based Functional Electrical Stimulation (hbFES). Since large surface electrodes were used to stimulate the denervated thigh muscles, we wanted to know if the skin was affected by this peculiar long-term treatment. Indeed, we demonstrated by two approaches that the epidermis decreases in thickness in the long term denervated persons, while it increased to almost pre-SCI values in hbFES compliant SCI persons. Read More

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http://dx.doi.org/10.4081/ejtm.2018.7914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317141PMC
November 2018

Peptide SIKVAV-modified chitosan hydrogels promote skin wound healing by accelerating angiogenesis and regulating cytokine secretion.

Am J Transl Res 2018 15;10(12):4258-4268. Epub 2018 Dec 15.

Department of Histology & Embryology and Medical Genetics, School of Basic Medical Sciences, Jiujiang University Jiujiang 332000, China.

Skin wound healing is complex and involves the processes of many factors, among which angiogenesis and inflammatory responses play important roles. New blood vessels provide nutrition and oxygen for skin wound repair. Cytokines in skin wounds, which include pro-inflammatory and anti-inflammatory factors, can modulate the inflammatory response. Read More

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December 2018

Droplet digital PCR for detection of mutation in formalin-fixed, paraffin-embedded melanoma tissues: a comparison with Cobas 4800, Sanger sequencing, and allele-specific PCR.

Am J Transl Res 2018 15;10(11):3773-3781. Epub 2018 Nov 15.

Division of Oncology, Slovakia JFM CU, Biomedical Center Martin JFM CU, Jessenius Faculty of Medicine in Martin (JFM CU), Commenius University in Bratislava Mala Hora 4C, 036 01 Martin.

Cutaneous melanoma has the worst prognosis of all skin cancers. Although emerging targeted therapies, such as B-Raf kinase inhibitor vemurafenib, improve prognosis they require an accurate and sensitive means of detecting the pathogenic mutation. We compared the sensitivity of four detection methods in formalin-fixed, paraffin-embedded melanoma biopsies from 87 consecutive melanoma patients with Breslow stage I-V disease (staging based on the depth of tumor of invasion). Read More

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November 2018

Topographic Sonoanatomy of Infraclavicular Brachial Plexus: Variability and Correlation with Anthropometry.

Anesth Essays Res 2018 Oct-Dec;12(4):814-818

Department of Anaesthesiology, AIIMS, New Delhi, India.

Objective: The aim of the study was to assess the effectiveness of ultrasound in analyzing topographic relationship of nerve cords with axillary artery at lateral infraclavicular level, their variations, and the distance from the skin and to correlate findings with anthropometric parameters.

Materials And Methods: Two hundred patients aged 18-75 years were enrolled for the study after informed written consent. A 7-12 MHz linear ultrasonic transducer was used for scanning of the brachial plexus at lateral infraclavicular fossa. Read More

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http://dx.doi.org/10.4103/aer.AER_140_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319080PMC
January 2019

Dsg1 deficiency causes lethal skin blistering.

J Invest Dermatol 2019 Jan 17. Epub 2019 Jan 17.

Ludwig-Maximilians-Universität (LMU) Munich, Institute of Anatomy and Cell Biology, Department I, Pettenkoferstrasse 11, D-80336 Munich / Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.01.002DOI Listing
January 2019

Reference Transcriptome for Deriving Marmoset Induced Pluripotent Stem Cells.

Methods Mol Biol 2019 ;1919:175-186

Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.

Limited access to primary tissue from various nonhuman primate (NHP) species represents a significant unmet need that hampers progress in understanding unique cellular diversity and gene regulation of specific tissues and organs in stem cell translational research. Most comparative biology studies have been limited to using postmortem tissue usually frozen specimens with limited utility for research. The generation of induced pluripotent stem cell (iPSC) lines from somatic cells, such as adult skin or blood cells, offers an alternative to invasive and ethically controversial interventions for acquiring tissue. Read More

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http://dx.doi.org/10.1007/978-1-4939-9007-8_13DOI Listing
January 2019

Improvement of diabetic wound healing by topical application of Vicenin-2 hydrocolloid film on Sprague Dawley rats.

BMC Complement Altern Med 2019 Jan 17;19(1):20. Epub 2019 Jan 17.

Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.

Background: Impaired wound healing is a debilitating complication of diabetes that leads to significant morbidity, particularly foot ulcers. The risk of developing diabetic foot ulcers for diabetic patients is 15% over their lifetime and approximately 85% of limb amputations is caused by non-healing ulcers. Unhealed, gangrenous wounds destroy the structural integrity of the skin, which acts as a protective barrier that prevents the invasion of external noxious agents into the body. Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12906-018-2427-yDOI Listing
January 2019
2 Reads

Inhibition of Pannexin 1 Reduces the Tumorigenic Properties of Human Melanoma Cells.

Cancers (Basel) 2019 Jan 16;11(1). Epub 2019 Jan 16.

Department of Anatomy and Cell Biology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON N6A5C1, Canada.

Pannexin 1 (PANX1) is a channel-forming glycoprotein expressed in many tissues including the skin. PANX1 channels allow the passage of ions and molecules up to 1 kDa, including ATP and other metabolites. In this study, we show that PANX1 is highly expressed in human melanoma tumors at all stages of disease progression, as well as in patient-derived cells and established melanoma cell lines. Read More

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http://dx.doi.org/10.3390/cancers11010102DOI Listing
January 2019

An exonic splicing enhancer mutation in causes aberrant alternative splicing and severe congenital hypothyroidism in Bama pigs.

Dis Model Mech 2019 Jan 15;12(1). Epub 2019 Jan 15.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Chaoyang District, Beijing 100101, China

Pigs share many similarities with humans in terms of anatomy, physiology and genetics, and have long been recognized as important experimental animals in biomedical research. Using an N-ethyl-N-nitrosourea (ENU) mutagenesis screen, we previously identified a large number of pig mutants, which could be further established as human disease models. However, the identification of causative mutations in large animals with great heterogeneity remains a challenging endeavor. Read More

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http://dmm.biologists.org/lookup/doi/10.1242/dmm.036616
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http://dx.doi.org/10.1242/dmm.036616DOI Listing
January 2019
1 Read

Histological and functional comparisons of four anatomical regions of porcine skin with human abdominal skin.

Anat Histol Embryol 2019 Jan 16. Epub 2019 Jan 16.

Department of Veterinary Medicine, Institute for Veterinary Anatomy, Freie Universität Berlin, Berlin, Germany.

Because of the shortage of human skin for research purposes, porcine skin has been used as a model of human skin. The aim of this study was to identify the region of German Landrace pig skin that could be used as the best possible substitute for human abdominal skin. Porcine samples were collected from the ear, flank, back and caudal abdomen; human abdominal skin samples were excised during plastic surgery. Read More

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http://dx.doi.org/10.1111/ahe.12425DOI Listing
January 2019
1 Read

Phosphorylated Akt1 expression is associated with poor prognosis in cutaneous, oral and sinonasal melanomas.

Oncotarget 2018 Dec 18;9(99):37291-37304. Epub 2018 Dec 18.

Department of Oral Diagnosis, Area of Pathology, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.

Melanomas are highly aggressive tumours derived from melanocytes, which occur most commonly in the skin. Occasionally, these tumours may appear in oral and sinonasal mucous membranes. In this study, we performed a comparative analysis of the Phosphorylated Akt1 (p-Akt1) expression in 144 patients affected by cutaneous (CM), 34 oral cavity (OM), and 31 sinonasal melanomas (SNM). Read More

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http://dx.doi.org/10.18632/oncotarget.26458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324666PMC
December 2018

Changes in the Layers of the Temple During Pinch Manipulation: Implications for Thread Lifting.

Dermatol Surg 2019 Jan 11. Epub 2019 Jan 11.

Department of Anatomy, Gachon University College of Medicine, Incheon, Republic of Korea.

Background: During minimally invasive aesthetic procedures, the skin is often pinched to facilitate filler injection or thread insertion into the desired layer. However, little is known about changes in the facial layers during pinch manipulation.

Objective: To determine which layer of the temple is lifted during pinching and whether the artery and the nerve are affected by pinching. Read More

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http://dx.doi.org/10.1097/DSS.0000000000001758DOI Listing
January 2019
2 Reads

Transient receptor potential melastatin-3 in the rat sensory ganglia of the trigeminal, glossopharyngeal and vagus nerves.

J Chem Neuroanat 2019 Jan 10;96:116-125. Epub 2019 Jan 10.

Division of Oral and Craniofacial Anatomy, Graduate School of Dentistry, Tohoku University, Sendai 980-8575, Japan.

Transient receptor potential melastatin-3 (TRPM3) is a nonselective cation channel, has permeability of Ca, and probably participates in thermosensitive nociception. In this study, immunohistochemistry for TRPM3 was conducted in the rat trigeminal, glossopharyngeal and vagal sensory ganglia. TRPM3-immunoreactivity was expressed by half of sensory neurons in the trigeminal (TG), petrosal (PG) and jugular ganglia (JG), and by about 80% of sensory neurons in the nodose ganglion (NG). Read More

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http://dx.doi.org/10.1016/j.jchemneu.2019.01.005DOI Listing
January 2019

The role of dietary non-heme iron load and peripheral nerve inflammation in the development of peripheral neuropathy (PN) in obese non-diabetic leptin-deficient ob/ob mice.

Neurol Res 2019 Jan 13:1-13. Epub 2019 Jan 13.

b Institute of Anatomy , University of Leipzig , Leipzig , Germany.

Introduction: Here, we investigated inflammatory signs of peripheral nerves in leptin-deficient obese ob/ob mice and the modulating effects of the exogenous iron load.

Methods: Ob/ob and ob/+ control mice were fed with high, standard, or low iron diet for four months.

Results: We found intraepidermal nerve fiber degeneration in foot skin and low-grade neuropathic abnormalities including mildly slowed motor and compound sensory nerve conduction velocities and low-grade macrophage and T-cell infiltration without overt neuropathology in sciatic nerves of all ob/ob mice. Read More

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https://www.tandfonline.com/doi/full/10.1080/01616412.2018.1
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http://dx.doi.org/10.1080/01616412.2018.1564191DOI Listing
January 2019
2 Reads

Melanoma types by in vivo reflectance confocal microscopy correlated with protein and molecular-genetic alterations: a pilot study.

Exp Dermatol 2019 Jan 12. Epub 2019 Jan 12.

Department of Surgery, Medicine, Dentistry and Morphological Sciences with interest in Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.

Cutaneous melanoma (CM) is one of the most prevalent skin cancers, which lacks both a prognostic marker and a specific and lasting treatment, due to the complexity of the disease and heterogeneity of patients. Reflectance confocal microscopy (RCM) in vivo analysis is a versatile approach offering immediate morphological information, enabling the identification of four primary cutaneous RCM CM types. Whether RCM CM types are associated with a specific protein and molecular-genetic profiles at the tissue level, remains unclear. Read More

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http://dx.doi.org/10.1111/exd.13877DOI Listing
January 2019
2 Reads

Differential Hepatotoxic Effects of Sodium Valproate at Different Doses in Albino Rats.

Kathmandu Univ Med J (KUMJ) 2018 Jan.-Mar;16(61):78-82

Department of Anatomy, Kathmandu University School of Medical Sciences, Dhulikhel, Kavre, Nepal.

Background Liver plays an essential role for transforming and clearing chemicals that may cause harmful effects to it. Sodium Valproate, renowned to be a potent antiepileptic drug, when taken in overdose may cause toxic effects to liver and other organs as well. Liver damage can be assessed with histological changes and measurement of enzymes produced by it. Read More

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January 2019

Premature aging and cancer development in transgenic mice lacking functional CYLD.

Aging (Albany NY) 2019 Jan;11(1):127-159

Molecular Oncology Unit, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT)/CIBERONC, Madrid 28040, Spain.

CYLD is a deubiquitinating enzyme known for its role as a tumor suppressor whose mutation leads to skin appendages tumors and other cancers. In this manuscript we report that the tumor suppressor CYLD, similarly to other renowned tumor suppressor genes, protects from premature aging and cancer. We have generated transgenic mice expressing the mutant CYLD protein, lacking its deubiquitinase function, under the control of the keratin 5 promoter, the K5-CYLD mice. Read More

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http://www.aging-us.com/article/101732/text
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http://dx.doi.org/10.18632/aging.101732DOI Listing
January 2019
2 Reads

Pectoral myology of limb-reduced worm lizards (Squamata, Amphisbaenia) suggests decoupling of the musculoskeletal system during the evolution of body elongation.

BMC Evol Biol 2019 Jan 10;19(1):16. Epub 2019 Jan 10.

Museum für Naturkunde Berlin, Leibniz-Institut für Evolutions- und Biodiversitätsforschung, Invalidenstr. 43, 10115, Berlin, Germany.

Background: The evolution of elongated body forms in tetrapods has a strong influence on the musculoskeletal system, including the reduction of pelvic and pectoral girdles, as well as the limbs. However, despite extensive research in this area it still remains unknown how muscles within and around bony girdles are affected by these reductions. Here we investigate this issue using fossorial amphisbaenian reptiles, or worm lizards, as a model system, which show substantial variation in the degree of reductions of girdles and limbs. Read More

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http://dx.doi.org/10.1186/s12862-018-1303-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329177PMC
January 2019

Regional thickness of facial skin and superficial fat: Application to the minimally-invasive procedures.

Clin Anat 2019 Jan 10. Epub 2019 Jan 10.

Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Center, BK21 PLUS Project, Yonsei University College of Dentistry, Seoul, South Korea.

Introduction: Various recently introduced minimally invasive treatment modalities are now widely used for enhancing the aging face. In a special, filler is used to increase the volume of tissue, and so understanding the regional thickness and distribution of the facial superficial fat is essential for optimizing minimally invasive procedures. The aim of this study was to establish the overall facial skin and superficial fat thicknesses using a 3D scanning system. Read More

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http://doi.wiley.com/10.1002/ca.23331
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http://dx.doi.org/10.1002/ca.23331DOI Listing
January 2019
2 Reads

Decreased MEPs during subcutaneous dissection for untethering surgery of a "true" lipomyelomeningocele: aggravated traction of the spinal cord by release of the sac from the original nest.

Childs Nerv Syst 2019 Jan 8. Epub 2019 Jan 8.

Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.

Purpose: It is well known that the preoperative enlarged sac in occult spinal dysraphism, in which the spinal cord is attached to its dome, can be associated with neurological deficits by aggravation of spinal cord traction. We experienced a similar phenomenon during the early stage of untethering surgery for "lipomyelomeningocele in a strict sense (LMMC)."

Clinical Presentation: We report a case of a 3-month-old girl with LMMC, which showed decreased motor evoked potentials (MEPs) in the lower extremities during the early stage of untethering surgery. Read More

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http://dx.doi.org/10.1007/s00381-019-04049-8DOI Listing
January 2019

Three-Dimensional Vascular Anatomical Study of the Tensor Fasciae Latae Muscle and Perforators.

J Reconstr Microsurg 2019 Jan 7. Epub 2019 Jan 7.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Dalhousie University, Halifax, Canada.

Background:  To harvest any flap on the lateral circumflex femoral artery (LCFA) including tensor fasciae latae (TFL) muscle, a precise description of the vascular anatomy is required. There have been conflicting reports of the vascular supply of TFL and its overlying skin. The objective of this study was to evaluate the anatomy of the TFL muscle according to the location, origin, type, caliber, and length of vessels that supply the muscle. Read More

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http://dx.doi.org/10.1055/s-0038-1677010DOI Listing
January 2019
2 Reads

Usefulness of the orbicularis oculi myocutaneous flap in periorbital reconstruction.

Arch Craniofac Surg 2018 Dec 27;19(4):254-259. Epub 2018 Dec 27.

Department of Dermatology, Pusan National University Hospital, Busan, Korea.

Background: The esthetic and functional outcomes of periorbital defect reconstruction are very important because of the complex anatomy and specialized functions of this region. The orbicularis oculi myocutaneous (OOMC) flap is useful for the reconstruction of periorbital defects. But, according to the location and depth of the defects, the reconstruction using OMC flaps with various techniques is rare. Read More

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http://dx.doi.org/10.7181/acfs.2018.02019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325325PMC
December 2018

Insights into atopic dermatitis gained from genetically defined mouse models.

J Allergy Clin Immunol 2019 Jan;143(1):13-25

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Skin Research Institute of Singapore (SRIS), Singapore; Singapore Immunology Network, A*STAR, Singapore. Electronic address:

Atopic dermatitis (AD) is characterized by severe pruritus and recurrent eczema with a chronic disease course. Impaired skin barrier function, hyperactivated T2 cell-type inflammation, and pruritus-induced scratching contribute to the disease pathogenesis of AD. Skin microbial alterations complicate the pathogenesis of AD further. Read More

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http://dx.doi.org/10.1016/j.jaci.2018.11.014DOI Listing
January 2019

Differences in microRNA expression between melanoma and healthy adjacent skin.

BMC Dermatol 2019 Jan 5;19(1). Epub 2019 Jan 5.

Department of Pathophysiology, Krasnoyarsk State Medical University, Krasnoyarsk, 660022, Russia.

Background: The tumor microenvironment is composed of cancer-associated fibroblasts, tumor-associated macrophages, endothelial cells, immune cells, signaling molecules and extracellular matrix structures, which closelycommunicate with the tumor via multiple mechanisms. MicroRNAs are paracrine regulators that provide a direct interaction between the microenvironment and cancer cells. In the presentstudy, we aimed to identify the microRNA expression profile in melanoma compared with thatin healthy adjacent skin, with a further assessment of altered microRNA signaling pathways and target genes. Read More

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http://dx.doi.org/10.1186/s12895-018-0081-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321655PMC
January 2019

Generation of an integration-free induced pluripotent stem cell line, FJMUi001-A, from a hereditary spastic paraplegia patient carrying compound heterozygous p.P498L and p.R618W mutations in CAPN1 (SPG76).

Stem Cell Res 2018 Nov 27;34:101354. Epub 2018 Nov 27.

Department of Neurology and Institute of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China. Electronic address:

The human iPS cell line, hiPS-SPG76 (FJMUi001-A), derived from skin fibroblasts from a 42-year-old male hereditary spastic paraplegia patient carrying compound heterozygous p.P498L (c.1493C > T) and p. Read More

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http://dx.doi.org/10.1016/j.scr.2018.11.015DOI Listing
November 2018

[The effectiveness of Ilizarov technique-based transverse tibial bone transport on treatment of severe diabetic foots complicated with systemic inflammation response syndrome].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2018 Oct;32(10):1261-1266

Department of Bone and Joint Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning Guangxi, 530021,

Objective: To evaluate the effectiveness of Ilizarov technique-based transverse tibial bone transport on the treatment of severe diabetic foot ulcer (Wagner grades 3 to 5) complicated with systemic inflammatory response syndrome (SIRS).

Methods: Between August 2014 and December 2017, 33 patients with severe diabetic foot and SIRS were treated with Ilizarov technique-based transverse tibial bone transport. There were 27 males and 6 females, with a mean age of 60. Read More

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http://www.rrsurg.com/article/10.7507/1002-1892.201805024
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http://dx.doi.org/10.7507/1002-1892.201805024DOI Listing
October 2018
3 Reads

Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull-meninges connections.

Nat Neurosci 2018 Dec 31. Epub 2018 Dec 31.

Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany.

Analysis of entire transparent rodent bodies after clearing could provide holistic biological information in health and disease, but reliable imaging and quantification of fluorescent protein signals deep inside the tissues has remained a challenge. Here, we developed vDISCO, a pressure-driven, nanobody-based whole-body immunolabeling technology to enhance the signal of fluorescent proteins by up to two orders of magnitude. This allowed us to image and quantify subcellular details through bones, skin and highly autofluorescent tissues of intact transparent mice. Read More

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http://dx.doi.org/10.1038/s41593-018-0301-3DOI Listing
December 2018
1 Read

Expression of Notch 3 and Jagged 1 Is Associated With Merkel Cell Polyomavirus Status and Prognosis in Merkel Cell Carcinoma.

Anticancer Res 2019 Jan;39(1):319-329

Division of Molecular Pathology, Department of Pathology, Tottori University Faculty of Medicine, Yonago, Japan

Background/aim: Merkel cell carcinoma (MCC) is a rare, aggressive, neuroendocrine skin cancer and most MCCs are related to infection with Merkel cell polyomavirus (MCPyV). Notch signaling modulates cell fate in various tissues including the skin during development and homeostasis, and its aberrant activity relates to onset and progression of various malignancies. Therefore, association of NOTCH1/ NOTCH2/NOTCH3/jagged 1 (JAG1) expression with MCPyV status and prognosis in MCC was investigated. Read More

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http://dx.doi.org/10.21873/anticanres.13114DOI Listing
January 2019

Evaluation of the Chemopreventive Activity of Grape Skin Extract Using Medium-term Oral Carcinogenesis Assay Induced by 4-Nitroquinoline 1-Oxide.

Anticancer Res 2019 Jan;39(1):177-182

Department of Biosciences, Federal University of São Paulo, UNIFESP, Santos, Brazil

Background/aim: The aim of this study was to evaluate the chemoprotective potential of grape skin extract following rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide (4NQO).

Materials And Methods: Male Wistar rats were distributed into four groups (n=5, per group): Control Group: free access to commercial diet and drinking water for 12 weeks; 4NQO Group: received 4NQO diluted in drinking water daily, for 12 weeks; Grape Skin Extract Group: free access to water and received grape skin extract incorporated with diet for 12 weeks; 4NQO + Grape Skin Extract Group: received 4NQO in drinking water daily and grape extract incorporated with diet for 12 weeks.

Results: Animals treated with grape skin extract revealed a significant reduction in epithelial dysplasia. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13095DOI Listing
January 2019
3 Reads

TNF-alpha and metalloproteases as key players in melanoma cells aggressiveness.

J Exp Clin Cancer Res 2018 Dec 28;37(1):326. Epub 2018 Dec 28.

Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, ISS, viale Regina Elena 299, 00161, Rome, Italy.

Background: Melanoma aggressiveness determines its growth and metastatic potential. This study aimed at identifying new molecular pathways controlling melanoma cell malignancy.

Methods: Ten metastatic melanoma cell lines were characterized by their proliferation, migration and invasion capabilities. Read More

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http://dx.doi.org/10.1186/s13046-018-0982-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309098PMC
December 2018

A New Approach to an Old Flap: A Technique to Augment Venous Drainage from the Paramedian Forehead Flap.

Plast Reconstr Surg 2019 Jan;143(1):269-271

Sheffield and London, United Kingdom From the Department of Plastic Surgery, Sheffield Teaching Hospitals NHS Foundation Trust; the Departments of Radiology and Plastic Surgery, Guy's and St Thomas' NHS Foundation Trust; and the Department of Anatomy, King's College London.

The paramedian forehead flap is commonly used in nasal reconstruction, and survival of the distal part of the flap is usually essential for a good cosmetic outcome. Venous congestion leading to tissue necrosis is a recognized complication with this flap. The standard paramedian forehead flap is designed with a number of aims. Read More

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http://dx.doi.org/10.1097/PRS.0000000000005121DOI Listing
January 2019

Neoadjuvant Treatments for Advanced Resectable Melanoma.

J Surg Oncol 2019 Jan 27;119(2):216-221. Epub 2018 Dec 27.

Division of Surgical Oncology, Department of Surgery, Winship Cancer Institute, Emory University, Atlanta, Georgia.

Neoadjuvant therapy has demonstrated promise as a treatment modality in resectable advanced-stage melanoma. Treatment has evolved beyond chemotherapy, with the utilization of biochemotherapy, immunotherapy, and targeted therapy in the neoadjuvant setting. These therapies have shown better progression-free survival and melanoma-specific survival when compared with patients that proceed directly to surgery. Read More

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http://dx.doi.org/10.1002/jso.25352DOI Listing
January 2019

Tofacitinib Treatment and Molecular Analysis of Cutaneous Sarcoidosis.

N Engl J Med 2018 12;379(26):2540-2546

From the Departments of Dermatology (W.D., D.T., A.G., B.K.), Immunobiology (W.D.), and Pathology (A.G.) and the Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine (N.E.), Yale School of Medicine, New Haven, CT.

There is evidence that Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling plays a role in the pathogenesis of sarcoidosis. We treated a patient with cutaneous sarcoidosis with the JAK inhibitor tofacitinib; the patient had not previously had a response to medications and had not received systemic glucocorticoids. This treatment resulted in clinical and histologic remission of her skin disease. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1805958
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http://dx.doi.org/10.1056/NEJMoa1805958DOI Listing
December 2018
3 Reads

Radiation Protection Responsibility in Brachytherapy.

Authors:
Bruce Thomadsen

Health Phys 2019 Feb;116(2):189-204

Department of Medical Physics, University of Wisconsin-Madison, 1005 Wisconsin Institutes for Medical Research, 1111 Highland Avenue, Madison, WI 53705.

Radiation protection in brachytherapy entails protecting members of the public, radiation professionals, and the patient from unnecessary radiation, as well as making sure that the radiation used in the patient's treatment is placed correctly with the correct dose distribution. Protecting members of the public from radiation emanating from brachytherapy sources implanted in a patient was an issue several decades ago, but with modern brachytherapy, the problem has mostly disappeared. The most frequent treatments are either low-dose-rate permanent implants for prostate cancer, or high-dose-rate procedures for gynecological, breast, or skin cancers. Read More

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http://dx.doi.org/10.1097/HP.0000000000001005DOI Listing
February 2019
2 Reads

Particulate matter induces inflammatory cytokine production via activation of NFκB by TLR5-NOX4-ROS signaling in human skin keratinocyte and mouse skin.

Redox Biol 2018 Dec 15;21:101080. Epub 2018 Dec 15.

Department of Biochemistry, Jeju National University School of Medicine, Jeju 63243, Republic of Korea. Electronic address:

Particulate matter (PM) increases levels of pro-inflammatory cytokines, but its effects on the skin remain largely unknown. We investigated the signal transduction pathway and epigenetic regulatory mechanisms underlying cellular inflammation induced by PM with a diameter of ≤ 2.5 (PM) in vitro and in vivo. Read More

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http://dx.doi.org/10.1016/j.redox.2018.101080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305701PMC
December 2018
1 Read

Identification of Embryonic Neural Plate Border Stem Cells and Their Generation by Direct Reprogramming from Adult Human Blood Cells.

Cell Stem Cell 2019 Jan 20;24(1):166-182.e13. Epub 2018 Dec 20.

Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), and DKFZ-ZMBH Alliance, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany. Electronic address:

We report the direct reprogramming of both adult human fibroblasts and blood cells into induced neural plate border stem cells (iNBSCs) by ectopic expression of four neural transcription factors. Self-renewing, clonal iNBSCs can be robustly expanded in defined media while retaining multilineage differentiation potential. They generate functional cell types of neural crest and CNS lineages and could be used to model a human pain syndrome via gene editing of SCN9A in iNBSCs. Read More

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http://dx.doi.org/10.1016/j.stem.2018.11.015DOI Listing
January 2019
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Periostin and CCN2 Scaffolds Promote the Wound Healing Response in the Skin of Diabetic Mice.

Tissue Eng Part A 2018 Dec 20. Epub 2018 Dec 20.

University of Western Ontario, Division of Oral Biology, London, Ontario, Canada ;

Impaired skin wounds represent a significant and growing complication associated with type II diabetes and effective clinical strategies to reproducibly induce wound resolution do not exist. As a class of secreted non-structural matrix proteins that modulate many cellular aspects of skin healing, matricellular proteins could represent a novel mechanism to promoting skin healing. Based on their role in the regulation of the proliferative phase of healing, we hypothesized that local delivery of periostin and CCN2 could suppress inflammation and progress wounds into the proliferative and remodeling phases of repair. Read More

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https://www.liebertpub.com/doi/10.1089/ten.TEA.2018.0268
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http://dx.doi.org/10.1089/ten.TEA.2018.0268DOI Listing
December 2018
6 Reads

Multiple cavernous hemangiomas of the lung and liver mimicking metastasis: A case report and literature review.

Medicine (Baltimore) 2018 Dec;97(51):e13509

Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-Sen University.

Rationale: Cavernous hemangiomas are benign vascular malformations that usually involve the skin, subcutaneous tissue, and liver. Described herein was multiple masses in the lung and liver mimicking metastasis, which was proved to be cavernous hemangiomas histologically.

Patient Concerns: A 78-year-old man with complaint of dizziness for 3 days was referred to the local hospital for medical attention. Read More

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http://dx.doi.org/10.1097/MD.0000000000013509DOI Listing
December 2018
5.723 Impact Factor

Decreased Expression of Vascular Endothelial Growth Factor Receptor 1 Contributes to the Pathogenesis of Hereditary Hemorrhagic Telangiectasia Type 2.

Circulation 2018 Dec;138(23):2698-2712

Einthoven Laboratory for Experimental Vascular Medicine, Department of Internal Medicine (Nephrology), Leiden University Medical Center, The Netherlands (J.H.T., G.G., H.C.d.B., T.J.R., K.R., F.L.).

Background: Hereditary Hemorrhagic Telangiectasia type 2 (HHT2) is an inherited genetic disorder characterized by vascular malformations and hemorrhage. HHT2 results from ACVRL1 haploinsufficiency, the remaining wild-type allele being unable to contribute sufficient protein to sustain endothelial cell function. Blood vessels function normally but are prone to respond to angiogenic stimuli, leading to the development of telangiectasic lesions that can bleed. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.033062DOI Listing
December 2018

Laterally Based Orbicularis Oculi Myocutaneous Flap: Revisiting for the Secondary Ectropion Correction.

J Craniofac Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Plastic and Reconstructive Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seoul, Korea.

Background: The management of lower eyelid ectropion is considered a challenge. Lower eyelid ectropion is conventionally reconstructed with a full-thickness skin graft or a local flap. However, complications as scar contracture and the recurrence of ectropion frequently occur. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005081DOI Listing
December 2018
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Efficacy of Dalbavancin and Telavancin in the Treatment of Acute Bacterial Skin and Skin Structure Infections.

Maedica (Buchar) 2018 Sep;13(3):208-212

Assistant Professor, Department of Anatomy, Maheshwara Medical College and Hospital, Patancheru, Sangareddy District, Telangana, India.

Objectives: Two glycopeptide analogues, such as dalbavancin and telavancin, with improved pharmacokinetic/pharmacodynamic parameters have been developed. These two glycopeptide analogues are approved by Food and Drug Administration (FDA) for treatment of various Gram-positive bacterial skin infections.

Materials And Methods: We have conducted an open labelled prospective randomized study to compare the efficacy of these two drugs. Read More

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http://dx.doi.org/10.26574/maedica.2018.13.3.208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290182PMC
September 2018

Regional skin histomorphology in adult greater cane rats (): A pilot study.

Int J Vet Sci Med 2018 Dec 16;6(2):219-226. Epub 2018 Nov 16.

Department of Veterinary Pathology, University of Ibadan, Ibadan, Nigeria.

The greater cane rat () demonstrated numerous dermal architectural peculiarities hitherto unreported. This investigation assessed and evaluated certain histologic features of skin samples from the fore and hind limbs, the neck, head, proximal to the ear and oro-nasal regions for follicular evaluations and micro anatomic assessments in the adult species. Twenty wild taken animals of equal gender distribution were used for histologic assessments of structural elements and histo-morphometric evaluations. Read More

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http://dx.doi.org/10.1016/j.ijvsm.2018.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286415PMC
December 2018

Reduction of PGRN increased fibrosis during skin wound healing in mice.

Histol Histopathol 2018 Dec 18:18076. Epub 2018 Dec 18.

Department of Forensic Medicine, Xuzhou Medical University; Xuzhou, Jiangsu, P.R. China.

Progranulin (PGRN) is a multi-functional growth factor known to be involved in regulating of development, cell cycle progression, cell motility, tumorigenesis and angiogenesis. Research has revealed that PGRN is a crucial mediator of skin wound healing. Nonetheless, the role of PGRN in the fibrosis process of cutaneous wound healing has not been identified. Read More

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http://dx.doi.org/10.14670/HH-18-076DOI Listing
December 2018
2.096 Impact Factor

Indications for the surgical resection of stage IV disease.

Authors:
Danielle M Bello

J Surg Oncol 2019 Jan 18;119(2):249-261. Epub 2018 Dec 18.

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.

Tumor biology and careful patient selection weigh heavily in determining the appropriate role of surgical resection in stage IV melanoma. Historically, surgical resection for highly selected patients with metastatic melanoma was the only treatment modality associated with improved long-term survival and the ability to provide palliation. With the new age of effective systemic therapies, the treatment of metastatic melanoma has become more intricate and future work is needed to better define the role for surgery within the current treatment paradigm. Read More

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http://doi.wiley.com/10.1002/jso.25326
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http://dx.doi.org/10.1002/jso.25326DOI Listing
January 2019
13 Reads

Calcium oscillations coordinate feather mesenchymal cell movement by SHH dependent modulation of gap junction networks.

Nat Commun 2018 12 18;9(1):5377. Epub 2018 Dec 18.

Dept. of Pathology, USC Keck School of Medicine, Los Angeles, CA, 90033, USA.

Collective cell migration mediates multiple tissue morphogenesis processes. Yet how multi-dimensional mesenchymal cell movements are coordinated remains mostly unknown. Here we report that coordinated mesenchymal cell migration during chicken feather elongation is accompanied by dynamic changes of bioelectric currents. Read More

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http://www.nature.com/articles/s41467-018-07661-5
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http://dx.doi.org/10.1038/s41467-018-07661-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299091PMC
December 2018
5 Reads

Quadriceps weakness associates with greater T1ρ relaxation time in the medial femoral articular cartilage 6 months following anterior cruciate ligament reconstruction.

Knee Surg Sports Traumatol Arthrosc 2018 Dec 17. Epub 2018 Dec 17.

Department of Orthopaedics, University of North Carolina at Chapel Hill, 102 Mason Farm Rd # 2, Chapel Hill, NC, 27599, USA.

Purpose: Quadriceps weakness following anterior cruciate ligament reconstruction (ACLR) is linked to decreased patient-reported function, altered lower extremity biomechanics and tibiofemoral joint space narrowing. It remains unknown if quadriceps weakness is associated with early deleterious changes to femoral cartilage composition that are suggestive of posttraumatic osteoarthritis development. The purpose of the cross-sectional study was to determine if quadriceps strength was associated with T1ρ relaxation times, a marker of proteoglycan density, of the articular cartilage in the medial and lateral femoral condyles 6 months following ACLR. Read More

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http://dx.doi.org/10.1007/s00167-018-5290-yDOI Listing
December 2018
2 Reads

A Safer Non-surgical Filler Augmentation Rhinoplasty Based on the Anatomy of the Nose.

Aesthetic Plast Surg 2018 Dec 17. Epub 2018 Dec 17.

Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University, 130 Dongdeok-ro, Jung-gu, Daegu, 41944, Republic of Korea.

Background: Filler augmentation rhinoplasty is a quick, non-surgical procedure that can produce outcomes comparable to open rhinoplasty surgery. However, the increased frequency of vascular complications has emerged as an important issue. The present study aimed to investigate measures to overcome the vascular complications based on the anatomy of the nose. Read More

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http://link.springer.com/10.1007/s00266-018-1279-7
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http://dx.doi.org/10.1007/s00266-018-1279-7DOI Listing
December 2018
5 Reads

The Antipruritic Effect of Phototherapy.

Authors:
Franz J Legat

Front Med (Lausanne) 2018 30;5:333. Epub 2018 Nov 30.

Department of Dermatology and Venerology, Medical University of Graz, Graz, Austria.

Phototherapy is widely used to treat inflammatory skin diseases such as psoriasis and atopic dermatitis. Repeated suberythemogenic doses of UV-light reduce inflammation in these diseases and ultimately may lead to a complete disappearance of cutaneous symptoms for weeks or months. Chronic pruritus is an important and highly distressing symptom of many of these inflammatory skin diseases. Read More

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http://dx.doi.org/10.3389/fmed.2018.00333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287194PMC
November 2018
1 Read