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Exp Dermatol 2021 May 9. Epub 2021 May 9.

Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.

Neutrophil extracellular traps (NETs) are implicated in the pathogenesis of multiple inflammatory dermatoses. However, characterization of NETs in neutrophilic dermatoses was performed on very limited number of patients; this limitation precluded definitive conclusions. In this case series of 57 patients, we compared the amounts of neutrophils producing NETs in cutaneous lesions of different entities of neutrophilic dermatoses (17 with pyoderma gangrenosum, 37 with Sweet's syndrome and three with subcorneal pustular dermatosis). Read More

Exp Ther Med 2021 Jun 19;21(6):650. Epub 2021 Apr 19.

Laboratory of Clinical Virology, Medical School, University of Crete, Heraklion 71003, Greece.

Pseudoexfoliation syndrome (PEX) is characterized by the deposition of proteinaceous material in the anterior ocular segment (resulting in ophthalmic pathologies such as glaucoma and increased risk of complications in cataract surgery), but also by several systemic manifestations. The involvement of peri-ocular tissues in PEX, including the eyelid skin, lacrimal gland, conjunctiva, orbital fat and vessels, as well as the optic nerve, has been reported by several previous studies. The peri-ocular effects of PEX include the development of eyelid laxity, conjunctival chalasis, tear film abnormalities, pronounced orbital fat atrophy in response to the administration of prostaglandin analogues in pseudoexfoliative glaucoma, deficient orbital vascular supply and biomechanical changes in both the eyeball and the optic nerve. Read More

BMC Musculoskelet Disord 2021 May 5;22(1):417. Epub 2021 May 5.

Department of Anatomy and Cell Biology, Lewis Katz School of Medicine, Temple University, 3500 North Broad Street, Philadelphia, PA, 19140, USA.

Background: We examined the effectiveness of a manual therapy consisting of forearm skin rolling, muscle mobilization, and upper extremity traction as a preventive treatment for rats performing an intensive lever-pulling task. We hypothesized that this treatment would reduce task-induced neuromuscular and tendon inflammation, fibrosis, and sensorimotor declines.

Methods: Sprague-Dawley rats performed a reaching and lever pulling task for a food reward, 2 h/day, 3 days/week, for 12 weeks, while simultaneously receiving the manual therapy treatment 3 times per week for 12 weeks to either the task-involved upper extremities (TASK-Tx), or the lower extremities as an active control group (TASK-Ac). Read More

Burns 2021 Mar 30. Epub 2021 Mar 30.

Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA; Shriners Hospitals for Children, Galveston, TX, USA. Electronic address:

Shortage in autograft to cover burn wounds involves a frequent use of cadaver skin (CS) as a temporary cover to prevent infection, dehydration and preparation of wounds for subsequent autografting. We aimed to establish an ovine model of burn wound healing using ovine CS (OCS). Quality and efficacy of fresh and frozen OCS overlaid on to excised 3rd degree flame burn wounds in sheep were evaluated in comparison to autograft. Read More

Aesthet Surg J 2021 May 4. Epub 2021 May 4.

Department of Clinical Anatomy, Mayo Clinic College of Medicine and Science, Rochester, MN.

Background: Facial aging is a multi-factorial process which involves all tissues of the face including skin, muscles, fat, ligaments, and bone. Whereas robust evidence is available for age-related changes of bone and facial fat, the influence of age on facial muscle activity is poorly understood.

Objectives: The objective of this study was to investigate the motor unit action potential (MUAP) of facial muscles by utilizing surface derived, non-invasive electromyography in young and old healthy volunteers. Read More

Exp Ther Med 2021 Jun 14;21(6):609. Epub 2021 Apr 14.

ENT Department, Bucharest Emergency University Hospital, 010271 Bucharest, Romania.

Seasonal allergic rhinitis (SAR) is one of the most frequent chronic conditions of the modern world. Pollen carried by the wind from pollinated trees is a major source of SAR. Betulaceae, Oleaceae and Platanus are the most important sources of airway sensitization with regard to tree pollen and, therefore, they are included in the official recommendations of skin prick testing by different official societies. Read More

Surg Radiol Anat 2021 May 1. Epub 2021 May 1.

Department of Neurosurgery, University Hospital of Bordeaux, Place Amélie Raba-Léon, 33076, Bordeaux, France.

Purpose: Neuronavigation is used in neurosurgical practice to locate the cortical structures. If this tool is unavailable, basic anatomical knowledge should be used. Craniometry has been rarely detailed in recent literature, systematically using bony landmarks. Read More

Ann R Coll Surg Engl 2021 May;103(5):e159-e164

Castle Hill Hospital, UK.

Submental flap (SF) is a reconstructive technique that can be utilised for reconstruction of medium to large oral cavity defects, head and neck cancer, and pharyngocutaneous fistula. The submental artery island flap is pedicled on the submental artery and veins. The vascular pedicle has a length of up to 8cm. Read More

Ann R Coll Surg Engl 2021 May;103(5):e169-e172

The Royal Marsden, London, UK.

We present two immediate breast reconstruction cases utilising deep inferior epigastric perforator (DIEP) flaps in the presence of upper transverse abdominal scars and their outcomes. The available evidence in relation to its impact on abdominal skin perfusion and published clinical experience is reviewed. Read More

Ann R Coll Surg Engl 2021 May;103(5):e165-e168

Queen Victoria Hospital NHS Trust, East Grinstead, UK.

Rhinophyma affects predominantly the Caucasian population and is rare in those with Fitzpatrick skin type IV-VI. Diagnosis is based on clinical evaluation. Prominent features include abnormal coloration and texture of skin, impaired vascularity, irregular nodular exophytic growth and telangiectasia. Read More

Eur Rev Med Pharmacol Sci 2021 04;25(8):3350-3364

Cardiovascular Division, Pompidou Hospital, University of Paris, Paris, France.

Objective: The purpose of this article was to review our clinical experience with COVID-19 patients observed in the Cardiovascular Division of Pompidou Hospital (University of Paris, France) and the Department of Neurology of the Eastern Piedmont University (Novara, Italy), related to the impact on the cardiovascular, hematological, and neurologic systems and sense organs.

Patients And Methods: We sought to characterize cardiovascular, hematological, and neurosensory manifestations in patients with COVID-19 and variants. Special attention was given to initial signs and symptoms to facilitate early diagnosis and therapy. Read More

Med Clin North Am 2021 May 2;105(3):531-550. Epub 2021 Apr 2.

Medicine, 231 Albert Sabin Way, Suite 5412, Cincinnati, OH 45267-0567, USA. Electronic address: https://twitter.com/mauradinicola.

Several neoplastic processes can involve the eye, either primarily or secondary to a systemic malignancy. The most common primary tumors of the eye include conjunctival and uveal melanoma, retinoblastoma, conjunctival and intraocular lymphoma, and ocular surface squamous neoplasia. Metastatic spread from systemic malignancies, especially of the breast and lung, also can involve the eye. Read More

J Med Case Rep 2021 Apr 30;15(1):252. Epub 2021 Apr 30.

Department of Dermatology, University of California, San Francisco, CA, 94115, USA.

Background: Aggressive squamous cell carcinomas (SCCs) present frequently in the context of chronic skin injury occurring in patients with the congenital blistering disease recessive dystrophic epidermolysis bullosa. Recently, these cancers were shown to harbor mutation signatures associated with endogenous deaminases of the active polynucleotide cytosine deaminase family, collectively termed APOBEC, and clock-like COSMIC [Catalogue of Somatic Mutations in Cancer] signatures, which are associated with normal aging and might result from cumulative DNA replication errors. We present a case of a nasal septal SCC arising in the context of recurrent injury, but also modest past tobacco use. Read More

J Orthop Surg Res 2021 Apr 29;16(1):286. Epub 2021 Apr 29.

Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, No. 37 Guoxuexiang, Chengdu, 610041, Sichuan, People's Republic of China.

Background: This study is to describe the design and surgical techniques of three- dimensional-printed porous implants for proximal giant cell tumors of bone and evaluate the short-term clinical outcomes.

Methods: From December 2016 to April 2020, 8 patients with giant cell tumor of bone in the proximal tibia underwent intralesional curettage of the tumor and reconstruction with bone grafting and three-dimensional-printed porous implant. Detailed anatomy data were measured, including the size of lesion and thickness of the subchondral bone. Read More

Life (Basel) 2021 Apr 17;11(4). Epub 2021 Apr 17.

Department and Graduate Institute of Biology and Anatomy, National Defense Medical Center, Taipei 114, Taiwan.

Background: During ablative fractional resurfacing (AFR) laser therapy, thermal damage to the skin is inevitable, resulting in inflammatory responses and small wounds. Corticosteroids are known for their anti-inflammatory effect. However, inappropriate application of corticosteroids carries the risk of delayed wound healing. Read More

Int J Mol Sci 2021 Apr 7;22(8). Epub 2021 Apr 7.

Department of Biomedical Chemistry, Faculty of Chemistry, University of Gdańsk, 80-308 Gdańsk, Poland.

Technological developments in the field of biologically active peptide applications in medicine have increased the need for new methods for peptide delivery. The disadvantage of peptides as drugs is their low biological stability. Recently, great attention has been paid to self-assembling peptides that can form fibrils. Read More

Cancers (Basel) 2021 Apr 1;13(7). Epub 2021 Apr 1.

LAQV/REQUIMTE, Laboratόrio de Microbiologia, Departamento de Ciências Biolόgicas, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal.

Melanoma is the deadliest form of skin cancer, primarily due to its high metastatic propensity and therapeutic resistance in advanced stages. The frequent inactivation of the p53 tumour suppressor protein in melanomagenesis may predict promising outcomes for p53 activators in melanoma therapy. Herein, we aimed to investigate the antitumor potential of the p53-activating agent SLMP53-2 against melanoma. Read More

Medicina (Kaunas) 2021 Apr 1;57(4). Epub 2021 Apr 1.

Department of Health Sciences, Division of Pathological Anatomy, University of Florence, 50139 Florence, Italy.

: Angiosarcomas are uncommon and extremely aggressive malignancies derived from vascular endothelial cells. Although they can occur anywhere in the body and at any age, they are more frequently found in the skin of the head and neck regions and in the elderly. Few cases have been recorded in deep soft tissues and in parenchymal organs. Read More

Br J Hosp Med (Lond) 2021 Apr 21;82(4):1-9. Epub 2021 Apr 21.

Department of General Surgery, Darlington Memorial Hospital, Darlington, UK.

Necrotising fasciitis is a severe, life-threatening and rapidly progressive soft tissue infection that often requires aggressive surgical management, with an estimated incidence of about 0.24-0.40 per 100 000 in the UK. Read More

N Engl J Med 2021 Apr;384(17):1646

Warren Alpert Medical School of Brown University, Providence, RI

Clin Anat 2021 Apr 28. Epub 2021 Apr 28.

The Spine Clinic of Oklahoma City, Oklahoma City, Oklahoma, USA.

The latest development in the anterior lumbar interbody fusion (ALIF) procedure is its application in the lateral position to allow for simultaneous posterior percutaneous screw placement. The technical details of the lateral ALIF technique have not yet been described. To describe the surgical anatomy relevant to the lateral ALIF approach we performed a comprehensive anatomical study. Read More

J Dermatol 2021 Apr 27. Epub 2021 Apr 27.

Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Dermoscopic images of pigmented lesions have distinct features on the sole where skin ridges and furrows exist. Pigmentation of benign nevus usually locates on the skin furrow, while the malignant melanoma is pigmented on the skin ridge. Correspondence between dermoscopy and pathology in the pigmented lesions on soles have been studied based on conventional vertical pathological images. Read More

Medicine (Baltimore) 2021 Apr;100(17):e22387

Assistant Professor, Department of Prosthetic Dentistry, College of Dentistry, King Khalid University, Abha, Kingdom of Saudi Arabia.

Introduction: Drug induced oral erythema multiforme a rare clinical entity which involves only the lips and oral mucosa without skin involvement. These lesions are difficult in diagnosing with other oral ulcerative lesions with similar clinical manifestations.

Patient Concerns: This article presents 2 case reports of Oral erythema multiforme in which drugs were the precipitating factor. Read More

Facial Plast Surg Clin North Am 2021 May 24;29(2):209-228. Epub 2021 Apr 24.

Department of Otolaryngology-Head & Neck Surgery, Division of Facial Plastic Surgery, Albert Einstein College of Medicine, New York, NY, USA; Department of Facial Plastic and Reconstructive Surgery, Northwell Health (North Shore LIJ), Manhasset, NY, USA. Electronic address:

The aging appearance of the lower eyelids is multifactorial, involving changes in the skin, orbital fat, orbicularis muscle, soft tissue of the midface, and tear trough. The extent of these changes differs in each case and happens in a background of volume loss that occurs with facial aging. We present the indications, advantages, and technique for volumizing transcutaneous lower blepharoplasty with fat transposition. Read More

J Biomater Appl 2021 Apr 28:8853282211012870. Epub 2021 Apr 28.

Jiangsu Medical Engineering Research Center of Gene Detection and Department of Forensic Medicine, Xuzhou Medical University, Xuzhou, China.

Faster recovery and fewer scars are ideal wound healing. We have demonstrated that the cannabinoid receptor 2 (CB) agonist Gp1a is beneficial to skin wound healing, which inhibits inflammation and fibrogenesis while promoting re-epithelialization. However, the systemic administration is imprecise and overqualified for a local skin wound. Read More

J Craniofac Surg 2021 May;32(Suppl 3):1275-1280

Division of Plastic, Aesthetic and Reconstructive Surgery, University of Miami, Miami, FL.

Abstract: Soft tissue deficits of the scalp due to trauma, infection, or tumor resection present a unique challenge to the reconstructive surgeon whose goal is to achieve excellent cosmesis in a hair bearing area without compromising coverage. While extensive undermining for large rotation flaps or free tissue transfer can provide necessary coverage, the pericranial flap is an excellent alternative for less ideal surgical candidates who cannot tolerate more extensive interventions or for patients who require long-term cancer surveillance. Elevation of the pericranial flap limits the need for back cuts through the skin and uses blunt dissection to preserve overlying hair follicles. Read More

Stem Cell Res 2021 Apr 15;53:102337. Epub 2021 Apr 15.

iPS Cell Advanced Characterization and Development Team, BioResource Research Center, RIKEN, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan. Electronic address:

Adrenoleukodystrophy (ALD) is an X-linked genetic disorder, characterized by demyelination in the central nervous system and adrenal insufficiency. Human induced pluripotent stem cell (hiPSC) lines derived from two Japanese male patients with ALD were generated from skin fibroblasts using retroviral vectors. The generated hiPSC lines showed self-renewal and pluripotency, and carried either a missense or a nonsense mutation in ABCD1 gene. Read More

Eur J Cancer Prev 2021 Apr 23. Epub 2021 Apr 23.

Institute of Anatomy, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia Research Unit 'Dr. Mirko Grmek', University Psychiatric Hospital 'Sveti Ivan', Zagreb, Croatia.

Objective: To examine whether there is heterogeneity in the risk factors for skin cancer among the high-risk population in Slovenia, a Central European country with the second-largest age-standardized melanoma-related mortality rate in Europe.

Methods: We analyzed data collected during the 'Euromelanoma Day' 2010-2019. The outcome was the prevalence of newly suspected skin cancer. Read More

Vopr Kurortol Fizioter Lech Fiz Kult 2021 ;98(2):45-54

Skin and venereal clinic N4, St.-Petersburg, Russia.

The scope of physical methods for correcting the pathological skin scars is rapidly growing but the results of their use are often unsatisfactory. An inadequate approach to therapy without taking into account the assessment of their effectiveness leads to relapses, increased growth of scar tissue or the absence of a clinically significant effect which requires strict scientific evidence in the course of benign scientific studies.

Objective: Scientometric analysis of evidence-based studies on the use of therapeutic physical factors in the correction of post-acne scars. Read More

Saudi Med J 2021 May;42(5):574-577

From the Unity of Plastic Surgery (Cannistrà), Bichat C.B. Hospital, and from the Pediatric Surgery Department (Al-Shaqsi), Armand Trousseau Hospital, Paris, France.

Objectives: To describe the surgical approach to the treatment of iatrogenic gynecomastia via peri-areolar incision.

Methods: In this study, we describe our experience in the surgical management of iatrogenic hormonal gynecomastia with our technique described for idiopathic gynecomastia. We treated 70 patients with gynecomastia at a plastic surgery unit between 2000 and 2016. Read More