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Med Phys 2019 Mar 20. Epub 2019 Mar 20.

Department of Radiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, 90024.

Purpose: The purpose of this work was to estimate scanner independent CTDI -to-fetal-dose coefficients for tube current modulated (TCM) and fixed tube current (FTC) CT examinations of pregnant patients of various gestational ages undergoing abdominal/pelvic CT examinations.

Methods: For 24 pregnant patients of gestational age from less than 5 to 36 weeks who underwent clinically-indicated CT examinations, voxelized models of maternal and fetal (or embryo) anatomy were created from abdominal/pelvic image data. Absolute fetal dose (D ) was estimated using Monte Carlo (MC) simulations of helical scans covering the abdomen and pelvis for TCM and FTC scans. Read More

Transbound Emerg Dis 2019 Mar 20. Epub 2019 Mar 20.

Departments of Production Animal Studies, University of Pretoria, Onderstepoort, South Africa.

Lumpy skin disease (LSD) is an important transboundary animal disease (TAD) of cattle with significant economic impact because of the implications for international trade in live animals and animal products. LSD is caused by a Capripoxvirus, lumpy skin disease virus (LSDV), and results in extensive hide and udder damage, fever and pneumonia. LSDV can be shed in semen of infected bulls for prolonged periods and transmitted venereally to cows at high doses. Read More

J Invest Surg 2019 Mar 19:1-6. Epub 2019 Mar 19.

b Anatomical Institute of Minimally Invasive Surgery , Southern Medical University , Guangzhou , China.

Purpose: With increasing use of the chimeric flap of the descending genicular artery, the authors systematically investigated the anatomy of its branches in cadavers.

Methods: Fifteen fresh cadaveric thighs were studied by anatomical dissection. The branches of the descending genicular arteries were skeletonized along their courses to the femoral arteries. Read More

Oncol Lett 2019 Apr 6;17(4):3735-3742. Epub 2019 Feb 6.

Division of General Medicine, Department of Medicine, Nihon University School of Medicine, Itabashi, Tokyo 173-8610, Japan.

Erythropoietin-producing hepatocellular (Eph) receptors and their ligand ephrins serve crucial roles in the interactions among epithelial cells. Eph receptor/ephrin signaling regulates cell functions, including proliferation, differentiation and migration, via these cell-cell interactions. We reported previously that EPHB2, a member of the Eph receptor family, was highly expressed in chemically induced cutaneous squamous cell carcinoma (cSCC) tissues in mice. Read More

Hand (N Y) 2019 Mar 17:1558944719829905. Epub 2019 Mar 17.

1 Massachusetts General Hospital, Division of Plastic and Reconstructive Surgery, Harvard Medical School, Boston, USA.

Background: Firework injuries to the hand can be devastating due to the explosive and ballistic nature of these devices. The aim of this study was to describe the injury and treatment characteristics of patients requiring surgery for firework-related hand injuries and to investigate which factors are associated with an increased utilization of health care resources.

Methods: A retrospective chart review of patients undergoing surgery for firework-related hand injuries at two American College of Surgeons level I trauma centers between 2005 and 2016 was performed. Read More

Cells 2019 Mar 15;8(3). Epub 2019 Mar 15.

Department of Anatomy and Convergence Medical Sciences, Gyeongsang National University School of Medicine, Jinju 52727, Korea.

The changes in telomere length and mitochondrial DNA copy number (mtDNAcn) are considered to be aging markers. However, many studies have provided contradictory or only fragmentary information about changes of these markers in animal models, due to inaccurate analysis methods and a lack of objective aging standards. To establish chronological aging standards for these two markers, we analyzed telomere length and mtDNAcn in 12 tissues-leukocytes, prefrontal cortex, hippocampus, pituitary gland, adrenal gland, retina, aorta, liver, kidney, spleen, skeletal muscle, and skin-from a commonly used rodent model, C57BL/6 male mice aged 2⁻24 months. Read More

Stem Cell Res 2019 Mar 7;36:101417. Epub 2019 Mar 7.

Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, China; Human Anatomy Department, Hebei Medical University, Hebei Province 050017, China. Electronic address:

We generated a human induced pluripotent stem cell (iPSC) line from the skin fibroblasts of a 62-year-old female patient clinically diagnosed with sporadic Parkinson's disease (PD). The generated iPSCs maintained their normal karyotype, expressed pluripotency stem cell markers, and were demonstrated to be capable of differentiating into cells representative of the three embryonic germ layers. The generated line could be used for PD modeling in order to understand the mechanisms that influence the disorder. Read More

Lancet Child Adolesc Health 2019 Mar 11. Epub 2019 Mar 11.

Molecular and Pharmaco-Epidemiology Unit, Department of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy. Electronic address:

Background: Germline variants in the melanocortin 1 receptor gene (MC1R) might increase the risk of childhood and adolescent melanoma, but a clear conclusion is challenging because of the low number of studies and cases. We assessed the association of MC1R variants with childhood and adolescent melanoma in a large study comparing the prevalence of MC1R variants in child or adolescent patients with melanoma to that in adult patients with melanoma and in healthy adult controls.

Methods: In this retrospective pooled analysis, we used the M-SKIP Project, the Italian Melanoma Intergroup, and other European groups (with participants from Australia, Canada, France, Greece, Italy, the Netherlands, Serbia, Spain, Sweden, Turkey, and the USA) to assemble an international multicentre cohort. Read More

Cancers (Basel) 2019 Mar 13;11(3). Epub 2019 Mar 13.

Institute of Anatomy, Medical Faculty, University Duisburg-Essen, Essen 45147, Germany.

Malignant melanoma is the most aggressive and treatment resistant type of skin cancer. It is characterized by continuously rising incidence and high mortality rate due to its high metastatic potential. Various types of cell adhesion molecules have been implicated in tumor progression in melanoma. Read More

Obstet Gynecol 2019 Mar 11. Epub 2019 Mar 11.

Departments of Obstetrics and Gynecology and Radiology, Abington Hospital, Jefferson Health, Abington, and Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.

Background: Uterine myomas encountered at cesarean delivery increase the complexity and risk of the procedure. Preoperative planning of such deliveries may help optimize patient outcomes. The application of three-dimensional printing technology is rapidly expanding in many surgical specialties. Read More

Parasitol Res 2019 Mar 14. Epub 2019 Mar 14.

Institute of Parasitology, Biomedical Research Center Seltersberg (BFS), Justus Liebig University Giessen, Schubertstr. 81, 35392, Giessen, Germany.

Antarctophthirus microchir is a sucking louse species belonging to the family Echinophthiriidae and has been reported to parasitize all species of the subfamily Otariinae, the sea lions. Former studies on this ectoparasite mainly required fixation, immobilization, or death of host species and especially examinations of adult male sea lions are still very rare. Between March and May 2018, adult individuals of a unique "urban" bachelor group of South American sea lions (Otaria flavescens) living directly in the city of Valdivia, Chile, were studied regarding their ectoparasite infestation status. Read More

Microscopy (Oxf) 2019 Mar 12. Epub 2019 Mar 12.

Microscopic Anatomy, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan.

The touch domes of mammalian hairy skin are mechanoreceptors characterized by the accumulation of Merkel cell-neurite complexes at the epidermal base. In this study, we examined the shape, size, and density of the touch dome of human skin of the forearm and the abdomen through scanning electron microscopy (SEM). Human skin samples were obtained from donated bodies, as well as a patient who underwent biopsy. Read More

Pediatr Pulmonol 2019 Mar 11. Epub 2019 Mar 11.

Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Background: Although bronchial responsiveness (BR) is usually categorized as normal or hyperresponsive to aid the diagnosis of asthma, it exists on a continuous spectrum, not in a dichotomous manner. We aimed to evaluate the distribution profile of BR in a general population of 7-year-olds.

Methods: In 2015, 7-year-old Korean children from a nationwide birth cohort study visited regional study hospitals for skin prick test, standard spirometry, and bronchial provocation to establish reference values for the general population. Read More

Orthop J Sports Med 2019 Mar 6;7(3):2325967119829051. Epub 2019 Mar 6.

Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Background: The quadriceps tendon is a versatile graft option, and the clinical implications of a quadriceps tendon harvest need to be further defined.

Purpose: To review surgical considerations for the safe harvest of a quadriceps tendon autograft for anterior cruciate ligament (ACL) reconstruction, with a focus on the risk of patellar fractures.

Study Design: Case series; Level of evidence, 4. Read More

Contraception 2019 Mar 8. Epub 2019 Mar 8.

Seattle Science Foundation, Seattle, WA.

Objective: Anatomic assessment of the medial upper arm to identify potential sites for insertion of the etonogestrel (ENG) implant.

Study Design: Forty female cadaveric arms were dissected. Two rows of 1 x 2cm dissection windows were created in the inner arm overlying the triceps approximately 2-3 and 4-5cm posterior to the bicipital sulcus (sulcus). Read More

PLoS One 2019 11;14(3):e0212869. Epub 2019 Mar 11.

Department of Genetics and Microbiology, Faculty of Biology and Biotechnology Maria Curie-Skłodowska University, Lublin, Poland.

An antifungal active fraction (AAF) from the coelomic fluid (CF) of the earthworm Dendrobaena veneta was isolated. The aim of the study was to analyze the antifungal activity of the AAF and to carry out chemical characterization of the fraction. The active fraction showed antifungal activity against a clinical C. Read More

J Hist Neurosci 2019 Mar 11:1-22. Epub 2019 Mar 11.

a Department of Psychology , University of Dundee , Dundee , Scotland , United Kingdom.

Experiences following stimulation of the senses have been recorded for millennia, and they could be related to the gross anatomy of the sense organs. Examination of their microanatomy was to await the development of achromatic microscopes in the early nineteenth century. Among the microscopic structures that were isolated and described were specialized sensory cells, called receptors, and they could be related to the stimuli that excited them. Read More

Medicine (Baltimore) 2019 Mar;98(10):e14702

Department of Paediatric Orthopaedics, Medical University of Lublin.

Rationale: In the recent years, growing interest is focused on the use of platelet-rich plasma (PRP) in wound healing and tissue regeneration. There are a number of papers regarding the usefulness of PRP in the healing of ulcerations, skin injures, bone loss or distraction osteogenesis. Most authors emphasize the safety of PRP usage due to its authogenic nature. Read More

Orthop Clin North Am 2019 Apr;50(2):193-209

Department of Orthopaedic Surgery, Nemours Alfred I. duPont Hospital for Children, 1600 Rockland Road, Wilmington, DE 19803, USA.

Osteogenesis imperfecta is a genetically and phenotypically heterogeneous disorder related to a defect or deficiency in the production of type I collagen. It is characterized by brittle bones, fractures, spine and extremity deformity, and a host of extraskeletal manifestations. Type I collagen is present in bone, tendons, ligaments, skin, dentin, and the sclera of the eye and other connective tissues. Read More

Sci Rep 2019 Mar 7;9(1):3821. Epub 2019 Mar 7.

Department of Internal Medicine, School of Korean Medicine, Pusan National University, Yangsan, South Korea.

Despite a long history, the clinical efficacy of cupping therapy is still under debate. This is likely due to the lack of direct evidence for the biological actions of cupping, since the short exposure of cells to vacuum condition rarely has affects cellular activity. In this study, the medicinal properties of a recent medical technology, non-thermal plasma, were added to classical cupping and designated as 'plasma cupping' (PC). Read More

Anticancer Res 2019 Mar;39(3):1501-1505

Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, U.S.A.

Background/aim: Diagnosis-specific scoring systems developed for predicting survival of patients with cerebral metastases from malignant melanoma (MM) were evaluated.

Patients And Methods: The new whole-brain radiotherapy (WBRT)-30-MM was created in homogeneously treated patients receiving 10×3 Gy of WBRT for cerebral metastases from MM. It consisted of three groups with significantly different 6-month survival rates of 0% (3-5 points), 30% (7 points) and 52% (9 points) (p=0. Read More

Sci Rep 2019 Mar 5;9(1):3440. Epub 2019 Mar 5.

Department of Burn and Plastic Surgery, Burns Institute, Burn & Plastic Hospital of PLA General Hospital, Fourth Medical Center of PLA General Hospital, Beijing, 100048, PR China.

Blast lung injury (BLI) caused by both military and civilian explosions has become the main cause of death for blast injury patients. By building three-dimensional (3D) models of rat explosion regions, we simulated the surface pressure of the skin and lung. The pressure distributions were performed at 5 distances from the detonation center to the center of the rat. Read More

Photodiagnosis Photodyn Ther 2019 Mar 2. Epub 2019 Mar 2.

Department of Dermatology, Xi Jing Hospital, the Fourth Military Medical University, Xi'an, 710032, PR China. Electronic address:

Background: Photodynamic therapy (PDT) is one of the treatment options for generalized facial flat warts, which results in elimination of virus and inhibition of proliferation of warts due to photochemical and phototoxic reactions. In this research, we attempted to evaluate the efficacy and safety profiles of a combination of 2940-nm laser and PDT for the treatment of generalized recalcitrant facial flat warts.

Methods: Retrospective analysis of the patients with recalcitrant facial warts was performed. Read More

Food Chem Toxicol 2019 Mar 2;127:42-52. Epub 2019 Mar 2.

Department of Biomaterials, D. Mendeleev University of Chemical Technology of Russia, Moscow, 125047, Russian Federation; Department of Technology of Chemical Pharmaceutical and Cosmetic Products, D. Mendeleev University of Chemical Technology of Russia, Moscow, 125047, Russian Federation. Electronic address:

This study focused on defining the in vitro behavior of amphiphilic poly-N-vinylpyrrolidone (Amph-PVP) nanoparticles toward whole blood, blood plasma and blood cells in order to assess nanoparticle blood compatibility. In addition, possible effects on endothelium cell growth/viability were evaluated. The Amph-PVP nanoparticles were formed via self-assembling in aqueous media and composed of a hydrophobic alkyl core and a hydrophilic PVP outer shell. Read More

Orthop J Sports Med 2019 Feb 28;7(2):2325967119830397. Epub 2019 Feb 28.

Hinsdale Orthopaedics, Westmont, Illinois, USA.

Background: Osteochondritis dissecans (OCD) is an idiopathic focal condition affecting the subchondral bone of joints, and it is increasingly prevalent among the active young adult population. For lesions that have failed nonoperative management, transarticular drilling and extra-articular drilling are surgical options. Although the extra-articular approach preserves the articular cartilage, it is technically challenging and could benefit from a study of surgical approach. Read More

J Korean Med Sci 2019 Mar 22;34(8):e66. Epub 2019 Feb 22.

Department of Anatomy, Dongguk University School of Medicine, Gyeongju, Korea.

Background: Gross anatomy and sectional anatomy of a monkey should be known by students and researchers of veterinary medicine and medical research. However, materials to learn the anatomy of a monkey are scarce. Thus, the objective of this study was to produce a Visible Monkey data set containing cross sectional images, computed tomographs (CTs), and magnetic resonance images (MRIs) of a monkey whole body. Read More

Mediators Inflamm 2019 28;2019:1936769. Epub 2019 Jan 28.

Department of Anatomy, Chonbuk National University Medical School, Jeonju, Jeonbuk 54896, Republic of Korea.

Cold and hot thermal therapies are widely used as a traditional therapy in many cultures and are often prescribed in the treatment of various musculoskeletal and neurological conditions which present themselves to primary care physicians. However, there are no reports that investigated either the effects of cold and hot thermal therapies on the skin inflammation of trimellitic anhydride- (TMA-) induced dermatitis-like contact hypersensitivity (CHS) mouse model, or the mechanism of thermal therapy on allergic skin inflammation. Therefore, in this study, to reveal the anti-inflammatory effect of thermal therapy and its mechanism on TMA-induced CHS, we analyzed ear-swelling response (ear edema), vascular permeability, serum IgE levels, histological examination, and histamine and Th2 cytokine levels. Read More

Arkh Patol 2019 ;81(1):9-17

Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia, Saint Petersburg, Russia.

Mycosis fungoides (MF) is the most common primary cutaneous epidermotropic T-cell lymphoma (80%). The accurate diagnosis of MF confirmed only by clinical, histological and immunohistochemical signs amounts to 50-75%.

Objective: To investigate genetic markers (FOXP3, STAT4, IL-12B) for the early diagnosis of MF, to estimate the informative value of used diagnostic techniques (histology, immunophenotyping), and to determine clonality by the T-cell receptor γ-chain genes. Read More

J Trauma Acute Care Surg 2019 Mar 1. Epub 2019 Mar 1.

University of Michigan Morphomics Analysis Group (MAG).

Background: REBOA is a valuable resuscitative adjunct in a variety of clinical settings. In resource-limited or emergency environments, REBOA may be required with delayed or absent image-guidance or verification. Catheter insertion lengths may be informed by making CT correlations of skeletal landmarks with vascular lengths. Read More

Eur J Orthop Surg Traumatol 2019 Mar 2. Epub 2019 Mar 2.

St. Vincent's & Mercy Hospitals, Melbourne, Australia.

Hamstrings identification and subsequent graft harvest can be made difficult by body habitus and variability in tendon anatomy. We describe a 'sentinel' blood vessel near the insertions of gracilis and semitendinosus to facilitate identification. A prospective study of 100 patients (100 knees) undergoing primary arthroscopic ACL reconstruction (via the anterior approach) with hamstrings graft was conducted. Read More

Eur J Pharmacol 2019 Feb 28. Epub 2019 Feb 28.

Dr Stanislaw Sakiel's Center for Burn Treatment, Jana Pawła II 2, 41-100 Siemianowice Śląskie, Poland; Chair and Department of Descriptive and Topographic Anatomy, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Jordana 19, 41-808 Zabrze Rokitnica, Poland.

An alternative to cultured skin cell grafts usage in burn treatment is the graft of allogenic stem cells. We verified whether amniotic stem cells are better than the present therapeutic standard: grafts of autologous keratinocytes and fibroblasts along with autologous adipose-derived stem cells, and whether amniotic stem cells can support the growth of autologous keratinocytes and fibroblasts in the culture. The study was performed on the material from 18 amnia. Read More

Hepatobiliary Pancreat Dis Int 2019 Feb 21. Epub 2019 Feb 21.

Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1601, Japan; Department of Liver disease, University of Miyazaki Hospital, Miyazaki, Japan.

Background: Monocyte-derived fibrocytes play an important role in the progression of fibrosis in the skin, lungs, heart and kidney. However, the contribution of fibrocytes to liver fibrosis is unclear. The aim of this study was to investigate whether fibrocytes contributed to fibrosis progression in the livers of carbon tetrachloride (CCl)-treated mice. Read More

Chem Biol Interact 2019 Feb 27;304:61-72. Epub 2019 Feb 27.

Department of Biochemistry, Faculty of Medicine, University of Niš, Bulevar dr Zorana Đinđića 81, 18000, Niš, Serbia.

This study examined the nephroprotective effects of 15 different anthocyanins from the bilberry extract on the acute kidney injury caused by CCl. The acute nephrotoxicity in rats was induced 24 h after the treatment with a single dose of CCl (3 mL/kg, i.p. Read More

Exp Dermatol 2019 Mar 2. Epub 2019 Mar 2.

Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan, Republic of China.

Increased matrix metalloproteinase 1 (MMP-1) expression is a feature of photo-aged skin. We investigated the effects of baicalein and sulforaphane on ultraviolet B (UVB) irradiation induced MMP-1 expression and apoptosis using human dermal fibroblasts. UVB irradiation not only increased MMP-1 expression, but also caused apoptosis. Read More

J Oral Maxillofac Surg 2019 Feb 5. Epub 2019 Feb 5.

Professor and Vice President, Seattle Science Foundation, Seattle, WA; Department of Anatomical Sciences, St George's University, Grenada, West Indies.

Purpose: The buccal nerve (BN) supplies sensation to the skin over the anterior part of the buccinator, buccal mucosa, and buccal gingivae corresponding to the second and third molar teeth. Some dental anatomy books depict the main trunk of the BN coursing over the buccal shelf of the mandible, which leads to a serious misunderstanding of this anatomy. Therefore, this study aimed to show the course of the BN on the retromolar area and establish new evidence-based anatomy for appropriate BN blockade. Read More

Biol Eng Med 2018 Jun 24;3(3). Epub 2018 May 24.

Anatomy Department, Southern Illinois University School of Medicine, Carbondale, Il, USA.

All progressive muscle contractile impairments, including advanced age-related muscle power decline, need permanent management. Most elderly persons, in particular octogenarians, spend small amounts of time in daily physical activity, resulting in a decline in body condition with more and more frequent hospitalizations and finally potentially forcing them to bed permanently. Further several neurological injuries, which are even more acutely debilitating than those problems related to aging, are responsible for early limitation of mobility. Read More

Bio Protoc 2019 Jan;9(2)

Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Postoperative pain is highly debilitating and hinders recovery. Opioids are the main pain medication used for acute postoperative pain. Given the devastating opioid addiction and overdose epidemic across the US, non-opioid pain therapeutics are desperately needed. Read More

Int J Trichology 2019 Jan-Feb;11(1):8-13

Department of Anatomy, School of Biomedical & Allied Health Sciences, College of Health Sciences, University of Ghana, Accra, Ghana.

Context: Relatively scanty literature on autochthonic African Negroid hair morphology provokes research interest for anthropological, forensic, and cosmetic purposes.

Aims: This study aimed to contribute basic morphological information on Ghanaian African hairs.

Settings And Design: The study was done in selected second-cycle schools in Accra, Ghana, using convenient sampling. Read More

Chin Clin Oncol 2019 Feb;8(1):10

Division of Hematologic Malignancies and Hematopoietic Stem Cell Transplantation, Department of Medical Oncology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.

Cutaneous T-cell lymphomas (CTCLs) are a heterogeneous and relatively rare family of extranodal non-Hodgkin's lymphomas (NHL) that are primarily localized to the skin. Most patients present with cutaneous patches, plaques, tumors, more rarely with erythroderma. The type of skin lesions and the surface extent of skin involvement, as well as the presence of extracutaneous disease, are the most important prognostic factors in patients with CTCL. Read More

Chin Clin Oncol 2019 Feb;8(1)

Department of Dermatology and Cutaneous Biology, Jefferson University Hospital, Philadelphia, PA, USA.

Background: Mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma, remains a challenge for clinicians to stage and manage. Classically, MF is determined through histopathologic evidence of a neoplastic infiltrate within the epidermis. In certain patients, however, the infiltrate extends into the hair follicles and sweat glands. Read More

Phys Med Biol 2019 Feb 28. Epub 2019 Feb 28.

Department of Anatomy, Ajou University, Seoul, Korea (the Republic of).

In the present study, to overcome the limitations of the previous voxel-type reference computational phantoms, a pair of new reference Korean phantoms, called mesh-type reference Korean phantoms (MRKPs), were developed for the adult male and female in a high-quality/fidelity mesh format. The developed phantoms include all target and source regions required for effective dose calculation, even micrometer-scale target and source regions of the respiratory and alimentary tract organs, skin, urinary bladder, and eye lens. The developed phantoms, which are in the mesh format, can be directly used in Monte Carlo codes without voxelization. Read More

Br J Community Nurs 2019 Mar;24(Sup3):S28-S33

Reader, Centre for Medical Education Programme Director, MSc in Wound Healing and Tissue Repair, Cardiff University School of Medicine, College of Biomedical and Life Sciences.

It is well known that advancing age is a factor that affects the normal course of wound healing. The population over the age of 65 years is increasing globally, and this may be accompanied by an increase in the number of individuals experiencing delayed wound healing. There is a breadth of research to show that age-related changes in the epidermis and dermis change the skin's ability to resist damage and injury. Read More

Rinsho Shinkeigaku 2019 Feb 28. Epub 2019 Feb 28.

Department of Neurology, Kyoto University Graduate School of Medicine.

A 21-year-old woman presented with a chief complaint of generalized tonic-clonic seizures occurring once a month at night since the age of 14. The patient was treated with clonazepam plus levetiracetam, but seizure frequency was not reduced. After the detailed re-examination of her history of illness, it was revealed that she has been suffering from transient and recurrent choreoathetoid attacks triggered by sudden voluntary movements since she was a junior high school student, and it recently increased in frequency. Read More

Sensors (Basel) 2019 Feb 24;19(4). Epub 2019 Feb 24.

Institute of Biomedical Mechatronics, Johannes Kepler University, 4040 Linz, Austria.

Electromyography (EMG), the measurement of electrical muscle activity, is used in a variety of applications, including myoelectric upper-limb prostheses, which help amputees to regain independence and a higher quality of life. The state-of-the-art sensors in prostheses have a conductive connection to the skin and are therefore sensitive to sweat and require preparation of the skin. They are applied with some pressure to ensure a conductive connection, which may result in pressure marks and can be problematic for patients with circulatory disorders, who constitute a major group of amputees. Read More

Medicine (Baltimore) 2019 Feb;98(8):e14567

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China.

Radiation therapy can have adverse effects on normal tissue and cause chronic ulcers. The purpose of this study was to compare breast cancer patients who underwent single-stage reconstruction with patients who underwent 2-stage reconstruction for chronic radiation-induced necrotic ulcers of the chest wall.This retrospective study comprised of 50 patients with chronic radiation-induced chest wall ulcers who underwent chest wall reconstruction in our hospital between January 2002 and January 2016. Read More

Medicine (Baltimore) 2019 Feb;98(8):e14537

Department of Infectious Disease.

Rationale: Acute fibrinous and organizing pneumonia (AFOP) is an uncommon type of acute lung injury associated with infection, connective tissue disorders, drug exposure, and hematologic malignancies.

Patient Concerns: A 53-year-old female presented with intermittent fever, chills, and dry cough since 10 days. Chest computed tomography scan showed multiple bilateral patchy infiltrates. Read More

N Engl J Med 2019 Feb;380(9):858

University of Texas M.D. Anderson Cancer Center, Houston, TX

Clin Anat 2019 Feb 27. Epub 2019 Feb 27.

Division of Clinical Anatomy, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Western Cape, South Africa.

Introduction: Millions of people are infected with human immunodeficiency virus (HIV); however, limited research focuses on post-mortem HIV detection. Post-mortem HIV testing is vital since medical records are not always available, and the HIV status can be unknown. The aims of this study were to review the available literature and determine the most efficient HIV test for post-mortem samples, the optimal tissue or bodily fluid to be tested, and the duration that HIV remains reliably detectable. Read More

Muscle Nerve 2019 Feb 27. Epub 2019 Feb 27.

The NEMO Center in Milan, Neurorehabilitation Unit, University of Milan, ASST Niguarda Hospital.