759,082 results match your criteria Skin & Allergy News[Journal]


Comparative Study of Frozen and Paraffin-Embedded Sections: Evaluation of Inflammatory Dermatoses.

Isr Med Assoc J 2019 Feb;21(2):82-84

Department of Dermatology, Sourasky Tel Aviv Medical Center, Tel Aviv, Israel.

Background: Frozen section (FS) is often performed when histopathological evaluations are urgently required for implementation of therapeutic measures. In dermatology, this method is most commonly used to evaluate excision margins of tumors. FS are also routinely employed to differentiate toxic epidermal necrolysis from staphylococcal scalded skin syndrome. Read More

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February 2019

Risk factors and self-perception for facial aging among Nepalese population.

J Cosmet Dermatol 2019 Feb 17. Epub 2019 Feb 17.

Department of Dermatology, B.P. Koirala Institute of Health Sciences, Dharan, Nepal.

Background: Facial appearance has increasing importance to individuals and women, in particular. Till date, there are no reports of the extrinsic factors influencing skin aging in Nepalese population.

Objectives: To assess the risk factors and self-perception for facial aging in Nepalese population. Read More

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http://dx.doi.org/10.1111/jocd.12885DOI Listing
February 2019

Nutrition and its role in human evolution.

J Intern Med 2019 Feb 17. Epub 2019 Feb 17.

Vice Chancellor and Dean for Agriculture and Life Sciences, Texas A&M AgriLife, College Station, TX, USA.

Our understanding of human evolution has improved rapidly over recent decades, facilitated by large-scale cataloguing of genomic variability amongst both modern and archaic humans. It seems clear that the evolution of the ancestors of chimpanzees and hominins separated 7-9 million years ago with some migration out of Africa by the earlier hominins; Homo sapiens slowly emerged as climate change resulted in drier, less forested African conditions. The African populations expanded and evolved in many different conditions with slow mutation and selection rates in the human genome, but with much more rapid mutation occurring in mitochondrial DNA. Read More

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http://dx.doi.org/10.1111/joim.12878DOI Listing
February 2019

Characterizing Perceptions Around the Patient-Oncologist Relationship: a Qualitative Focus Group Analysis.

J Cancer Educ 2019 Feb 16. Epub 2019 Feb 16.

Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

The purpose of the current study was to characterize the experiences of cancer patients and their caregiver/family members around their relationship with their oncologist, health care team, and the hospital environment. Participants were recruited from The Ohio State University Comprehensive Cancer Center. Participant sociodemographic factors were assessed. Read More

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http://dx.doi.org/10.1007/s13187-019-1481-6DOI Listing
February 2019

Report: A case report on Nevirapine induced exfoliative dermatitis.

Pak J Pharm Sci 2019 Jan;32(1):221-222

Department of General Medicine, Rajiv Gandhi institute of medical sciences, Kadapa, India.

Drug induced adverse drug reactions is more common in long term therapy particularly in immune compromised patients. Most of the drugs causing dermatological reactions like skin rashes, pruritus, steven johnson syndrome and exfoliative dermatitis. Nevirapine is the first line drug for human immunodeficiency virus (HIV) infection from the category of non-nucleoside reverse transcriptase enzyme inhibitor (NNRTI). Read More

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January 2019

Preventive and therapeutic effects of aqueous extract of Spinacia oleracea on Psoriatic patches in albino rats.

Pak J Pharm Sci 2019 Jan;32(1):35-42

Department of Pharmacology, Faculty of Pharmacy & Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.

Psoriasis has become a topic of global concern because of consistency in its prevalence according to Global Report on Psoriasis 2016, however, till date, no therapy has provided complete cure of this disease and no useful measure was discovered to prevent it or eliminate the risk of its relapse. Hence, the present study was designed to evaluate anti-psoriatic effects of Spinacia oleracea due to its anti-inflammatory, anti-oxidant, anti-proliferative and skin-strengthening contents. Psoriasis was induced by oral potassium iodide solution which was then determined by two methods i. Read More

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January 2019

Predictive equation for post-mortem interval using spectrophotometric values of post-mortem lividity: A pilot study.

Forensic Sci Int 2019 Jan 19;297:47-55. Epub 2019 Jan 19.

Department of Forensic Pathology and Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan. Electronic address:

The colour of post-mortem lividity and control skin of 86 cadavers was measured spectrophotometrically to obtain L (value), a (chroma) and b (hue) values. In addition, left heart blood (n = 58), right heart blood (n = 57) and blood from the femoral vein (n = 21) were measured. Using these data, we analysed the relationship between post-mortem lividity, control skin and blood colours. Read More

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http://dx.doi.org/10.1016/j.forsciint.2019.01.014DOI Listing
January 2019

Postpartum post-traumatic stress disorder: Associated perinatal factors and quality of life.

J Affect Disord 2019 Feb 10;249:143-150. Epub 2019 Feb 10.

Department of Health Sciencies, University of Jaen, Jaen, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Madrid, Spain.

Background: The relationship between obstetric variables and postpartum post-traumatic stress disorder (PTSD), and its influence on quality of life (QoL), have scarcely been studied.

Objective: Determine the prevalence of PTSD at postpartum weeks 4 and 6, and its relation with perinatal variables and quality of life METHOD: A cross-sectional study with 2990 Spanish puerperal women in Spain. Data were collected on socio-demographic and obstetric variables, and on newborns. Read More

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http://dx.doi.org/10.1016/j.jad.2019.01.042DOI Listing
February 2019

Exopolysaccharides from Cyanobacterium aponinum induce a regulatory dendritic cell phenotype and inhibit SYK and CLEC7A expression in dendritic cells, T cells and keratinocytes.

Int Immunopharmacol 2019 Feb 14;69:328-336. Epub 2019 Feb 14.

Faculty of Medicine, University of Iceland, Biomedical Center, Vatnsmyrarvegur 16, IS-101 Reykjavik, Iceland; Department of Immunology, Landspitali-The National University Hospital of Iceland, Bld 14 at Eiriksgata, IS-101 Reykjavik, Iceland; Center for Rheumatology Research, Landspitali-The National University Hospital of Iceland, Bld 14 at Eiriksgata, IS-101 Reykjavik, Iceland. Electronic address:

Regular bathing in the Blue Lagoon has beneficial effects on psoriasis. Previously, we showed that exopolysaccharides (EPS-Ca) secreted by Cyanobacterium aponinum, a dominating organism in the Blue Lagoon, increased IL-10 secretion by human dendritic cells (DCs). In addition, co-culturing allogeneic CD4 T cells with DCs matured in the presence of EPS-Ca increased differentiation of T cells into T regulatory cells at the cost of the disease inducing Th17 cells. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.01.044DOI Listing
February 2019

Synthesis and structure-activity relationship of tyrosinase inhibiting novel bi-heterocyclic acetamides: Mechanistic insights through enzyme inhibition, kinetics and computational studies.

Bioorg Chem 2019 Jan 26;86:459-472. Epub 2019 Jan 26.

College of Natural Sciences, Department of Biological Sciences, Kongju National University, Gongju 32588, South Korea. Electronic address:

The present research was designed for the selective synthesis of novel bi-heterocyclic acetamides, 9a-n, and their tyrosinase inhibition to overwhelm the problem of melanogenesis. The structures of newly synthesized compounds were confirmed by spectral techniques such as H NMR, C NMR, and EI-MS along with elemental analysis. The inhibitory effects of these bi-heterocyclic acetamides (9a-n) were evaluated against tyrosinase and all these molecules were recognized as potent inhibitors relative to the standard used. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.01.036DOI Listing
January 2019

Regulation of the pleiotropic effects of tissue resident mast cells.

J Allergy Clin Immunol 2019 Feb 14. Epub 2019 Feb 14.

Institute of Clinical Nutrition, University of Hohenheim, Fruwirthstr. 12, D-70599 Stuttgart, Germany. Electronic address:

Mast cells, best known for their detrimental role in allergic diseases, act in a diverse array of physiological and pathological functions, made possible by the plurality of mast cell types. Their various developmental avenues and their distinct sensitivity to (micro-) environmental conditions convey extensive heterogeneity, resulting in diverse functions. We briefly summarize this heterogeneity, elaborate on molecular determinants that allow mast cells to communicate with their environment to fulfill their tasks, discuss their protease repertoire stored in secretory lysosomes, and consider different aspects of mast cell signaling. Read More

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http://dx.doi.org/10.1016/j.jaci.2019.02.004DOI Listing
February 2019

Combination of microneedles and microemulsions to increase celecoxib topical delivery for potential application in chemoprevention of breast cancer.

Int J Pharm 2019 Feb 14. Epub 2019 Feb 14.

Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Brazil. Electronic address:

In spite of the high incidence of breast cancer worldwide, there are few strategies for its chemoprevention, and they have limited adherence mainly due to their serious adverse effects. As a new approach for local breast cancer chemoprevention, we developed and optimized microemulsions for topical delivery of celecoxib to the breast skin, and evaluated their combination with microneedles to improve drug penetration for localization in the mammary tissue. Microemulsions containing water at 15% (ME-15), 29% (ME-29) and 60% (ME-60) were obtained and characterized. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.02.011DOI Listing
February 2019

Effects of an Attachment-Based Intervention in Infancy on Children's Autonomic Regulation during Middle Childhood.

Biol Psychol 2019 Feb 14. Epub 2019 Feb 14.

Department of Psychological and Brain Sciences, University of Delaware, United States.

The present study used a longitudinal randomized clinical trial to test whether an early intervention has causal effects on children's autonomic nervous system regulation. When children were infants, parents involved with Child Protective Services received Attachment and Biobehavioral Catch-up (ABC; N = 43), an intervention that promotes sensitive parenting, or a control intervention (N = 53). When children were 9 years old, children whose parents had received ABC exhibited higher respiratory sinus arrhythmia and lower heart rate at rest and during a parent-child interaction than children in the control group. Read More

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http://dx.doi.org/10.1016/j.biopsycho.2019.01.006DOI Listing
February 2019

Skin cancer risk factors and screening among sexual minority and heterosexual women.

J Am Acad Dermatol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology, Emory University School of Medicine, Atlanta, GA; Regional Telehealth Services, VA Southeast Network VISN 7, Decatur, Georgia, USA.

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http://dx.doi.org/10.1016/j.jaad.2019.02.024DOI Listing
February 2019

Co-activation of macrophages and T cells contribute to chronic GVHD in human IL-6 transgenic humanised mouse model.

EBioMedicine 2019 Feb 13. Epub 2019 Feb 13.

Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan. Electronic address:

Background: Graft-versus host disease (GVHD) is a complication of stem cell transplantation associated with significant morbidity and mortality. Non-specific immune-suppression, the mainstay of treatment, may result in immune-surveillance dysfunction and disease recurrence.

Methods: We created humanised mice model for chronic GVHD (cGVHD) by injecting cord blood (CB)-derived human CD34CD38CD45RA haematopoietic stem/progenitor cells (HSPCs) into hIL-6 transgenic NOD/SCID/Il2rgKO (NSG) newborns, and compared GVHD progression with NSG newborns receiving CB CD34 cells mimicking acute GVHD. Read More

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http://dx.doi.org/10.1016/j.ebiom.2019.02.001DOI Listing
February 2019

SOX2 epidermal overexpression promotes cutaneous wound healing via activation of EGFR/MEK/ERK signaling mediated by EGFR ligands.

J Invest Dermatol 2019 Feb 14. Epub 2019 Feb 14.

Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, USA. Electronic address:

Oral mucosa contains a unique transcriptional network that primes oral wounds for rapid resolution in humans. Our previous work identified genes that were consistently upregulated in the oral mucosa and demonstrated that induction of one of the identified genes, transcription factor SOX2, promoted cutaneous wound healing in mice. In this study, we investigated the molecular and cellular mechanisms by which SOX2 accelerates wound healing in skin. Read More

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http://dx.doi.org/10.1016/j.jid.2019.02.004DOI Listing
February 2019

Molecular genomic profiling of melanocytic nevi.

J Invest Dermatol 2019 Feb 14. Epub 2019 Feb 14.

Melanoma Institute Australia, The University of Sydney, NSW, Australia; Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.

The benign melanocytic nevus is the commonest tumor in humans and rarely transforms into cutaneous melanoma. Elucidation of the nevus genome is required to better understand the molecular steps of progression to melanoma. We performed whole genome sequencing on a series of 14 benign melanocytic nevi, consisting of both congenital and acquired types. Read More

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http://dx.doi.org/10.1016/j.jid.2018.12.033DOI Listing
February 2019

Combining primary care surveillance and a meta-analysis to estimate the incidence of the clinical manifestations of Lyme borreliosis in Belgium, 2015-2017.

Ticks Tick Borne Dis 2018 Dec 28. Epub 2018 Dec 28.

Scientific Directorate of Epidemiology and public health, Sciensano, J. Wytsmanstraat 14, 1050, Brussels, Belgium. Electronic address:

Lyme borreliosis (LB) is an important tick-borne disease which can cause a broad range of symptoms mainly affecting the skin, the nervous system and the joints. This study aims to estimate the incidence of the different clinical manifestations of LB in Belgium. The incidence of erythema migrans (EM) was estimated through the network of sentinel general practices at 97. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2018.12.007DOI Listing
December 2018

Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with biologics.

J Am Acad Dermatol 2019 Feb 7. Epub 2019 Feb 7.

University of Alabama, Birmingham, Alabama.

Psoriasis is a chronic, inflammatory multisystem disease that affects up to 3.2% of the US population. This guideline addresses important clinical questions that arise in psoriasis management and care, providing recommendations based on the available evidence. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.11.057DOI Listing
February 2019

Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with awareness and attention to comorbidities.

J Am Acad Dermatol 2019 Feb 7. Epub 2019 Feb 7.

Baylor Scott and White, Dallas, Texas.

Psoriasis is a chronic, inflammatory, multisystem disease that affects up to 3.2% of the US population. This guideline addresses important clinical questions that arise in psoriasis management and care, providing recommendations on the basis of available evidence. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.11.058DOI Listing
February 2019

Abatacept initiation in rheumatoid arthritis and the risk of serious infection: A population-based cohort study.

Semin Arthritis Rheum 2019 Jan 25. Epub 2019 Jan 25.

Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, 3755 Cote Ste-Catherine, H-461 Montreal, Québec H3T 1E2, Canada; Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Québec, Canada. Electronic address:

Objective: To assess whether abatacept as initial biologic disease-modifying antirheumatic drug (DMARD) in the treatment of rheumatoid arthritis is associated with an increased risk of serious infections, including bone and joint, gastrointestinal, respiratory tract, skin and soft tissue, and urinary tract, when compared with other biologic DMARDs.

Methods: We performed a population-based cohort study among patients newly-treated with biologic DMARDs within the US-based Truven MarketScan® population and Supplemental US Medicare from 2007 to 2014. Cox proportional hazards models were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of serious infections requiring hospitalisation associated with initiation of abatacept, compared with initiation of other bDMARDs, after controlling for age and deciles of the propensity score. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.01.009DOI Listing
January 2019

Switchable sniff-cam (gas-imaging system) based on redox reactions of alcohol dehydrogenase for ethanol and acetaldehyde in exhaled breath.

Talanta 2019 May 27;197:249-256. Epub 2018 Dec 27.

Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan; Department of Biomedical Devices and Instrumentation, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan. Electronic address:

Measuring the volatile organic compounds (VOCs) released from a human is a promising method for noninvasive disease screening and metabolism assessment. Selectively imaging multiple VOCs derived from human breath and skin gas is expected to improve current gas analysis techniques. In this study, a gas-imaging system (sniff-cam) that can be used to simultaneously image the concentration distribution of multiple VOCs, namely, ethanol (EtOH) and acetaldehyde (AcH), was developed. Read More

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http://dx.doi.org/10.1016/j.talanta.2018.12.070DOI Listing

Integral Facial Management of the Aesthetic Patient: The Skin Age Management Protocol.

Actas Dermosifiliogr 2019 Feb 13. Epub 2019 Feb 13.

Clínica Dermatológica Internacional, Madrid, España.

Aesthetic dermatology includes many minimally invasive therapies that can help our patients age gracefully and discreetly. Because it is hard to systematize these treatments to make patients aware of the options they have for the area of the face they want to improve, at Clínica Dermatológica Internacional, we have developed the Skin Age Management (SAM) protocol. In this article, we describe the protocol, which is aimed at helping doctors and patients to better understand and plan available treatments, underlining the advisability of combining techniques with the goal of achieving discreet changes to obtain what we consider to be optimum results, based on our experience at our center. Read More

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http://dx.doi.org/10.1016/j.ad.2018.10.016DOI Listing
February 2019

Colocutaneous fistula through ulcerative colitis and cancer to the pyoderma gangrenosum: a never-ending story for a single patient. Case report.

G Chir 2019 Jan-Feb;40(1):39-43

Background: Inflammatory bowel diseases may be associated with many extraintestinal complications, that in some cases can represent the first onset of these disorders. In particular during the course of the disease, Ulcerative Colitis develops extraintestinal manifestations very frequently. One of the rarest is pyoderma gangrenosum, a noninfectious neuthrophilic dermatosis, that can involve most commonly legs but also other parts of the skin or mucosas. Read More

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Changes in blood pressure associated with lead, manganese, and selenium in a Bangladeshi cohort.

Environ Pollut 2019 Feb 7;248:28-35. Epub 2019 Feb 7.

Division of Epidemiology and Biostatistics, University of Illinois at Chicago, School of Public Health, Chicago, IL, USA. Electronic address:

Background: Heavy metal contamination is widespread in Bangladesh. Previous studies have observed lead increases blood pressure over time. However, the role of other metal contaminants and essential micronutrients, which could also adversely affect blood pressure or act as protective factors, is understudied. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.01.129DOI Listing
February 2019

H NMR metabolomic analysis of skin and blubber of bottlenose dolphins reveal a functional metabolic dichotomy.

Comp Biochem Physiol Part D Genomics Proteomics 2019 Feb 10;30:25-32. Epub 2019 Feb 10.

Departamento de Recursos del Mar, Cinvestav Unidad Mérida, Mérida, Yucatán 97310, Mexico; CONACYT, Mexico. Electronic address:

The common bottlenose dolphin (Tursiops truncatus) is a carnivorous cetacean thriving in marine environment that is one of the apex predators of the marine food web. They are found in coastal and estuarine ecosystems which are known to be sensitive to environmental impacts. Dolphins are considered sentinel organisms for monitoring the health of coastal marine ecosystems in their role as predators that can bioaccumulate contaminants. Read More

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http://dx.doi.org/10.1016/j.cbd.2019.02.004DOI Listing
February 2019

Viral genome integration of canine papillomavirus 16.

Papillomavirus Res 2019 Feb 13. Epub 2019 Feb 13.

Department of Pathology, Georgetown University Medical Center, Washington, DC, USA.

Papillomaviruses infect humans and animals, most often causing benign proliferations on skin or mucosal surfaces. Rarely, these infections persist and progress to cancer. In humans, this transformation most often occurs with high-risk papillomaviruses, where viral integration is a critical event in carcinogenesis. Read More

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http://dx.doi.org/10.1016/j.pvr.2019.02.002DOI Listing
February 2019

A coculture system composed of THP-1 cells and 3D reconstructed human epidermis to assess activation of dendritic cells by sensitizing chemicals after topical exposure.

Toxicol In Vitro 2019 Feb 13. Epub 2019 Feb 13.

Department of Environmental Toxicology, Trier University, Trier, Germany. Electronic address:

A key event of the adverse outcome pathway for skin sensitization is the activation of dendritic cells (DC). To be most close to the in vivo situation, we combined for the first time reconstructed human epidermis (RHE) in coculture with THP-1 cells, as surrogate for DC. THP-1 cells were placed underneath RHE (SkinEthic™, OS-REp). Read More

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http://dx.doi.org/10.1016/j.tiv.2019.02.002DOI Listing
February 2019

Insight into Imiquimod Skin Permeation and Increased Delivery Using Microneedle Pre-treatment.

Eur J Pharm Biopharm 2019 Feb 13. Epub 2019 Feb 13.

Division of Advanced Materials and Healthcare Technologies, School of Pharmacy, The University of Nottingham, NG7 2RD, UK. Electronic address:

Basal cell carcinoma (BCC) is the most common skin cancer in humans. Topical treatment with imiquimod provides a non-invasive, self-administered treatment with relatively low treatment cost. Despite displaying excellent efficacy, imiquimod is only licensed by the FDA for superficial BCC. Read More

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http://dx.doi.org/10.1016/j.ejpb.2019.02.006DOI Listing
February 2019

UVB drives different stages of epigenome alterations during progression of skin cancer.

Cancer Lett 2019 Feb 13. Epub 2019 Feb 13.

Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA. Electronic address:

Exposure to ultraviolet B (UVB) irradiation results in multitude of cellular responses including generation of reactive oxygen species and DNA damage and is responsible for non-melanoma skin cancers (NMSCs). Although genetic mutation is well documented, the epi-mutation, the alteration in epigenetics, remains elusive. In this study, we utilized CpG Methyl-seq to identify a genome-wide DNA CpG methylation, to profile the DNA methylation in UVB-irradiated SKH-1 mouse skin epidermis and non-melanoma skin papillomas at various stages. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.02.010DOI Listing
February 2019

Successful Utilization of Optical Coherence Tomography as a Non-Invasive, Bedside Imaging Technique To Identify Residual Nodular Basal Cell Carcinoma at Well-Healed and Clinically Unidentifiable Biopsy Site.

J Am Acad Dermatol 2019 Feb 13. Epub 2019 Feb 13.

Laser & Skin Surgery Center of New York, New York, NY; The Ronald O. Perelman Department of Dermatology, New York University, New York, NY.

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http://dx.doi.org/10.1016/j.jaad.2019.02.012DOI Listing
February 2019

Response to 'Hydrochlorothiazide use and risk of nonmelanoma skin cancer: a nationwide case-control study from Denmark'.

J Am Acad Dermatol 2019 Feb 13. Epub 2019 Feb 13.

Department of Clinical Pharmacy & Toxicology, Maastricht UMC+, Maastricht, The Netherlands; CARIM School for Cardiovascular Disease, Maastricht University Medical Centre+, P.O. BOX 616 6200 MD, Maastricht, the Netherlands.

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http://dx.doi.org/10.1016/j.jaad.2019.01.087DOI Listing
February 2019

Reply to "Response to 'Hydrochlorothiazide use and risk of nonmelanoma skin cancer: a nationwide case-control study from Denmark' ".

J Am Acad Dermatol 2019 Feb 13. Epub 2019 Feb 13.

Department of Clinical Pharmacology and Pharmacy, University of Southern Denmark.

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http://dx.doi.org/10.1016/j.jaad.2019.02.019DOI Listing
February 2019

Identification of mineralocorticoid and glucocorticoid receptors on peripheral nociceptors: translation of experimental findings from animal to human biology.

Brain Res 2019 Feb 13. Epub 2019 Feb 13.

Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Anaesthesiology and Intensive Care Medicine, Charité University Berlin, Campus Virchow Klinikum, Berlin, Germany.

Evidence is accumulating that activation of mineralocorticoid (MR) and glucocorticoid (GR) receptors on peripheral sensory neurons modulates pain sensation. While the expression and exact anatomical localization of MR and GR in the various subpopulations of peripheral sensory neurons has been shown in animals, it is still unknown for the human skin. Therefore, we aimed to identify MR and GR mRNA and protein as well as the exact subpopulations of sensory neurons in human versus rat skin. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.02.015DOI Listing
February 2019

Understanding Skin Screening Practices Among Children at Elevated Risk for Melanoma to Inform Interventions for Melanoma Prevention and Control.

J Cancer Educ 2019 Feb 15. Epub 2019 Feb 15.

Huntsman Cancer Institute, 2000 Circle of Hope, Rm 4509, Salt Lake City, UT, 84112, USA.

Melanoma is the deadliest form of skin cancer. Screening can aid in early disease detection, when treatment is more effective. Although there are currently no consensus guidelines regarding skin screening for pediatric populations with elevated familial risk for melanoma, at-risk children with the help of their parents and healthcare providers may implement skin self-exams. Read More

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http://dx.doi.org/10.1007/s13187-019-01489-3DOI Listing
February 2019

Adverse Events from Emollient Use in Eczema: A Restricted Review of Published Data.

Dermatol Ther (Heidelb) 2019 Feb 15. Epub 2019 Feb 15.

Population Health Sciences, University of Bristol, Bristol, UK.

Atopic dermatitis/eczema is a chronic inflammatory skin condition, and emollients are the first-line treatment. Despite their widespread use, there is uncertainty about the frequency and type of adverse events associated with different emollients. We conducted a restricted review of published data on adverse events associated with emollient use in eczema. Read More

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http://dx.doi.org/10.1007/s13555-019-0284-3DOI Listing
February 2019

Alkali-soluble pectin suppresses IgE production in human myeloma cell line in vitro.

Cytotechnology 2019 Feb 15. Epub 2019 Feb 15.

Department of Creative Engineering, National Institute of Technology, Kitakyushu College, 5-20-1 Shii, Kokuraminami-ku, Kitakyushu, Fukuoka, 802-0985, Japan.

We found that strawberry (Fragaria x ananassa) extract has an IgE production suppressive activity and its oral administration improved skin manifestation in atopic dermatitis model mice. In present study, we identified an active substance using the IgE-producing human myeloma cell line U266. Gel filtration experiment indicated that the IgE suppressor was more than 6 kDa in molecular size. Read More

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http://dx.doi.org/10.1007/s10616-019-00306-5DOI Listing
February 2019

Resource allocation trade-offs and the loss of chemical defences during apple domestication.

Ann Bot 2019 Feb 16. Epub 2019 Feb 16.

Department of Entomology, Cornell University, Ithaca, USA.

Background And Aims: Most crops have been dramatically altered from their wild ancestors with the primary goal of increasing harvestable yield. A long-held hypothesis is that increased allocation to yield has reduced plant investment in defence and resulted in crops that are highly susceptible to pests. However, clear demonstrations of these trade-offs have been elusive due to the many selective pressures that occur concurrently during crop domestication. Read More

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http://dx.doi.org/10.1093/aob/mcz010DOI Listing
February 2019

How to treat Sjögren's syndrome.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

SS is a chronic, autoimmune disease of unknown aetiology for which there is no known curative treatment. Although dryness of the eyes and mouth are the classically described features, patients often experience drying of other mucosal surfaces and systemic manifestations, including fatigue and arthralgia. There is an association with other autoimmune diseases, especially thyroid disease, coeliac disease and primary biliary cholangitis. Read More

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http://dx.doi.org/10.1093/rheumatology/key363DOI Listing
February 2019

Understanding skin absorption of common aldehyde vapours from exposure during hazardous material incidents.

J Expo Sci Environ Epidemiol 2019 Feb 15. Epub 2019 Feb 15.

Emergency Response TIPS, LLC, Alexandria, VA, USA.

The toxic release of aldehyde vapours during a hazardous material (HAZMAT) incident primarily results in respiratory concerns for the unprotected public. However, skin absorption may be an important concurrent exposure route that is poorly understood for this scenario. This study provides experimental data on the skin absorption properties of common aldehydes used in industry, including acetaldehyde, acrolein, benzaldehyde and formaldehyde, in gaseous or vapour form using an adapted in vitro technique. Read More

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http://dx.doi.org/10.1038/s41370-019-0127-4DOI Listing
February 2019

Health-related quality of life in systemic sclerosis compared with other rheumatic diseases: a cross-sectional study.

Arthritis Res Ther 2019 Feb 15;21(1):61. Epub 2019 Feb 15.

Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.

Background: Systemic sclerosis (SSc) is a rare autoimmune disease characterized by fibrosis of the skin and the involvement of multiple internal organs. Previous studies reported poorer health-related quality of life (HRQoL) in patients with SSc compared with the general population. However, very little is known about how HRQoL in SSc patients compares with that in patients with other systemic autoimmune diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and Sjogren's syndrome (SjS). Read More

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http://dx.doi.org/10.1186/s13075-019-1842-xDOI Listing
February 2019

Analyses of histological and transcriptome differences in the skin of short-hair and long-hair rabbits.

BMC Genomics 2019 Feb 15;20(1):140. Epub 2019 Feb 15.

Anhui Key Laboratory of Livestock and Poultry Product Safety Engineering, Institute of Animal Husbandry and Veterinary Medicine, Anhui Academy of Agricultural Sciences, Hefei, 230031, Anhui, People's Republic of China.

Background: Hair fibre length is an important economic trait of rabbits in fur production. However, molecular mechanisms regulating rabbit hair growth have remained elusive.

Results: Here we aimed to characterise the skin traits and gene expression profiles of short-hair and long-hair rabbits by histological and transcriptome analyses. Read More

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http://dx.doi.org/10.1186/s12864-019-5503-xDOI Listing
February 2019
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Lysyl oxidase-a possible role in systemic sclerosis-associated pulmonary hypertension: a multicentre study.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

Rheumatology Unit, Bnai-Zion Medical Center, Haifa, Israel.

Objective: Lysyl oxidase (LOX) is an extracellular enzyme that cross-links collagen fibrils. LOX was found to be increased in serum of SSc patients and was suggested to be related to skin fibrosis, yet a vascular source of LOX has been demonstrated in idiopathic pulmonary arterial hypertension (iPAH). We aimed to validate elevated LOX serum levels in SSc and to study its correlation with clinical characteristics and investigate its main source at the tissue level. Read More

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http://dx.doi.org/10.1093/rheumatology/kez035DOI Listing
February 2019
1 Read

Silk fibroin scaffolds loaded with angiogenic genes in adenovirus vectors for tissue regeneration.

J Tissue Eng Regen Med 2019 Feb 15. Epub 2019 Feb 15.

National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou, People's Republic of China.

Vascularization remains a critical challenge in dermal tissue regeneration. In this study, a vascular endothelial growth factor (VEGF165) and angiopoietin-1 (Ang-1) dual gene co-expression vector that encoded green fluorescent protein (GFP) was constructed from an Arg-Gly-Asp-modified adenovirus. Silk fibroin (SF) scaffolds loaded with adenovirus vectors were fabricated by freeze-drying method. Read More

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http://dx.doi.org/10.1002/term.2819DOI Listing
February 2019

Efficacy of microneedling with topical vitamin C in the treatment of melasma.

J Cosmet Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Faculty of Medicine, Department of Dermatology, Sohag University, Sohag University Hospital, Sohag, Egypt.

Background: Despite the wide therapeutic options available for the treatment of melasma, including many active topical medications, technologies with lights and peelings, clinical control of this disorder is extremely challenging.

Objectives: To evaluate the effect of microneedling with topical vitamin C in the treatment of melasma.

Methods: Thirty female patients with melasma received six sessions of microneedling with addition of topical vitamin C every two weeks. Read More

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http://dx.doi.org/10.1111/jocd.12878DOI Listing
February 2019

Human scalp hair: Modulation by various factors and hormones do estrogens inhibit or stimulate-A perplexing perspective.

Authors:
Edwin D Lephart

J Cosmet Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Physiology and Developmental Biology and The Neuroscience Center, College of Life Science, Brigham Young University, Provo, Utah.

Several journal reports, reviews, and commentaries over the last 20-25 years have pointed out the controversy attached to 17β-estradiol's inhibitory or stimulatory influence on hair follicle growth/cycling citing rodent (murine) and human results. While 17β-estradiol is the most potent sex steroid hormone in the body and has almost equal affinity for estrogen receptor (ER) alpha (α) and beta (β), there appears to be specific ER-mediated effects on scalp hair follicles/growth, etc. Additionally, the newly discovered G protein-coupled estrogen receptor (GPR30 or GPER) and the orphan receptor, estrogen-related receptor (ERR) gamma (γ), in skin and other tissue sites have potential impacts of how estrogens via these receptors may alter scalp hair characteristics, but this remains to be elucidated. Read More

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http://dx.doi.org/10.1111/jocd.12888DOI Listing
February 2019

Parry-Romberg syndrome treatment with fat transfer and a new bleaching formula.

J Cosmet Dermatol 2019 Feb 15. Epub 2019 Feb 15.

ISAPS, Athens, Greece.

Parry-Romberg syndrome is a hemifacial atrophy which can be complicated by melasma. We present two cases of Parry-Romberg syndrome, treated by fat transfer and bleaching of the skin using a modified "Kligman's formula." The atrophy, as well as the skin dyschromia, improved, and the results were stable. Read More

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http://dx.doi.org/10.1111/jocd.12819DOI Listing
February 2019

Healthier Rhythm, Healthier Brain? Integrity of Circadian Melatonin and Temperature Rhythms Relates to the Clinical State of Brain-Injured Patients.

Eur J Neurol 2019 Feb 15. Epub 2019 Feb 15.

University of Salzburg, Department of Psychology, Centre for Cognitive Neuroscience, Hellbrunner Strasse 34, A-5020, Salzburg.

Introduction: Healthy circadian rhythmicity has been suggested to relate to a better state of brain-injured patients and to support the emergence of consciousness in patient groups characterised by a relative instability thereof such as patients with disorders of consciousness (DOC).

Methods: Going beyond earlier studies, we have adopted a systems-level perspective and, using multilevel modelling, assessed the joint predictive value of three indexes of circadian rhythm integrity derived from skin temperature variations, melatoninsulfate (aMT6s) secretion, and physical activity (wrist actigraphy) patterns for DOC patients' (13 unresponsive wakefulness syndrome [UWS]; 7 minimally conscious (exit) state [E/MCS]) behaviourally assessed state (Coma Recovery Scale-Revised [CRS-R] score). Additionally, we have assessed in a subset 16 patients whether patients' behavioural repertoire (CRS-R score) varies with (i) time of day or (ii) offset from the body temperature maximum (BTmax), that is when cognitive performance is expected to peak. Read More

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http://dx.doi.org/10.1111/ene.13935DOI Listing
February 2019

Nested case-control study investigating the diagnostic role of tissue eosinophilia in adverse cutaneous drug reactions.

J Eur Acad Dermatol Venereol 2019 Feb 15. Epub 2019 Feb 15.

Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background: Although tissue-eosinophilia has traditionally been considered diagnostically supportive of adverse cutaneous drug reactions (ACDRs), studies have suggested it is neither a sensitive nor a specific finding in drug eruptions (DEs).

Objectives: Determining whether skin-tissue eosinophilia is a reliable indicator of ACDR.

Methods: A nested case-control retrospective study conducted in a cohort of 170 patients at a single institution. Read More

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http://dx.doi.org/10.1111/jdv.15509DOI Listing
February 2019

Abnormal α-synuclein deposits in skin nerves: intra- and inter-laboratory reproducibility.

Eur J Neurol 2019 Feb 15. Epub 2019 Feb 15.

Philipps University, Marburg, Germany.

Background: Visualization of phosphorylated α-synuclein at serine 129 (p-syn) in skin nerves is a promising test for the in vivo diagnosis of synucleinopathies. Here we aimed to establish the intra- and inter-laboratory reproducibility of quantification of intraneural p-syn immunoreactivity in two laboratories with a major expertise (Würzburg and Bologna).

Methods: We enrolled 43 patients affected by Parkinson's disease (PD: 21 patients), Dementia with Lewy Body (DLB: 1), REM sleep behavior disorder (RBD: 11), Multiple System Atrophy (MSA-P: 4) and small fiber neuropathy (SFN: 6). Read More

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http://dx.doi.org/10.1111/ene.13939DOI Listing
February 2019
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