753,699 results match your criteria Skin & Allergy News[Journal]


Detection and quantification of methicillin-resistant Staphylococcus aureus in fresh broiler meat at retail in Germany.

Int J Food Microbiol 2018 Nov 22;292:8-12. Epub 2018 Nov 22.

German Federal Institute for Risk Assessment (BfR), Department Biological Safety, Berlin, Germany. Electronic address:

The aim of this study was to detect, to quantify and to characterize MRSA in broiler meat samples with skin. Furthermore, we compared an isolation method using a second selective enrichment step (method A) with a simpler method omitting this step (method B). For quantification we used a direct plating method on selective agar plates and a "Most probable number" (MPN) technique for estimation of low numbers of MRSA. Read More

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November 2018
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The therapeutic potential of curcumin: A review of clinical trials.

Eur J Med Chem 2018 Dec 7;163:527-545. Epub 2018 Dec 7.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 11369, Iran; Department of Chemistry, Richardson College for the Environmental Science Complex, The University of Winnipeg, Winnipeg, MB, R3B 2G3, Canada. Electronic address:

Curcuma longa L., its derived extracts and even its major compound curcumin has a long history of use and doubtless effectiveness, reported through increasingly detailed in vitro, ex vivo, in vivo and even clinical trials. Regarding its biological effects, multiple health-promoting, disease-preventing and even treatment attributes has been remarkably highlighted. Read More

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December 2018
3 Reads

Early response of C2C12 myotubes to a sub-cytotoxic dose of hemorrhagic metalloproteinase HF3 from Bothrops jararaca venom.

J Proteomics 2018 Dec 12. Epub 2018 Dec 12.

Laboratório Especial de Toxinologia Aplicada, Center of Toxins, Immune-Response and Cell Signaling (CeTICS), Instituto Butantan, São Paulo, Brazil. Electronic address:

Manifestations of local tissue damage, such as hemorrhage and myonecrosis, are among the most dramatic effects of envenomation by viperid snakes. Snake venom metalloproteinases (SVMPs) of the P-III class are main players of the hemorrhagic effect due to their activities in promoting blood vessel disruption. Hemorrhagic Factor 3 (HF3), a P-III class SVMP from Bothrops jararaca, shows a minimum hemorrhagic dose of 240 fmol on rabbit skin. Read More

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December 2018
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Synthesis and characterization of nanostructured lipid-poloxamer organogels for enhanced skin local anesthesia.

Eur J Pharm Sci 2018 Dec 12. Epub 2018 Dec 12.

Human and Natural Sciences Center, Federal University of ABC, Santo André, SP, Brazil. Electronic address:

The aim of this study was to synthesize a novel drug delivery system using organogels (ORGs) and characterize its physicochemical properties, in vitro and ex vivo permeation abilities, cytotoxicity and in vivo local anesthetic effects. The ORG formulations contained a mixture of oleic acid-lanolin (OA-LAN), poloxamer (PL407), and the commonly used local anesthetic lidocaine (LDC). The main focus was to evaluate the impact of LAN and PL407 concentrations on the ORG structural features and their biopharmaceutical performance. Read More

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December 2018
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Myosin Heavy Chain 10 (MYH10) Gene Silencing Reduces Cell Migration and Invasion in the Glioma Cell Lines U251, T98G, and SHG44 by Inhibiting the Wnt/β-Catenin Pathway.

Med Sci Monit 2018 Dec 15;24:9110-9119. Epub 2018 Dec 15.

Department of Neurosurgery, Suizhou Central Hospital, Suizhou, Hubei, China (mainland).

BACKGROUND The myosin heavy chain 10 or MYH10 gene encodes non-muscle myosin II B (NM IIB), and is involved in tumor cell migration, invasion, extracellular matrix (ECM) production, and epithelial-mesenchymal transition (EMT). This study aimed to investigate the effects of the MYH10 gene on normal human glial cells and glioma cell lines in vitro, by gene silencing, and to determine the signaling pathways involved. MATERIAL AND METHODS The normal human glial cell line HEB, and the glioma cell lines, U251, T98G, and SHG44 were studied. Read More

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December 2018
2 Reads

Ulnar Artery Occlusion and severity markers of vasculopathy in Systemic sclerosis: a multicenter cross-sectional study.

Arthritis Rheumatol 2018 Dec 15. Epub 2018 Dec 15.

Department of Internal Medicine and Clinical Immunology, CHU Rennes, Univ Rennes, France.

Objective: to evaluate the association of ulnar artery occlusion (UAO) assessed by Doppler Ultrasonography (dUS) with the severity markers of systemic sclerosis (SSc) METHODS: 204 unselected patients fulfilling 2013 ACR/EULAR classification criteria for SSc were included in this cross-sectional multicenter study. All patients benefit from bilateral hand dUS evaluating the presence of UAO and clinical/paraclinical visceral evaluation according to current guidelines. Univariable and multivariable ordinal regression models were conducted, grading the severity of UAO as "no UAO", "only one UAO" and "UAO on both hands" and assessing its association with clinical features of SSc. Read More

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December 2018
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Imbalance of peripheral follicular helper T lymphocyte subsets in active vitiligo.

Pigment Cell Melanoma Res 2018 Dec 15. Epub 2018 Dec 15.

NSERM U1035, BMGIC, Immuno-dermatology ATIP-AVENIR, University of Bordeaux, Bordeaux, France.

Vitiligo is an autoimmune disease characterized by the presence of several autoantibodies, some of which are directed against melanocyte components and have been shown to be associated with the progression of the disease. However, the mechanism involved in the production of autoantibodies remains unclear. Follicular helper CD4 T cells (TFH) are specialized in B cell activation and antibody production, especially the TFH cell subsets type 2 and type 17. Read More

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December 2018
2 Reads

Effectiveness of a theory-based sun-safe randomised behavioural change trial among Australian adolescents.

Psychooncology 2018 Dec 15. Epub 2018 Dec 15.

Australian Institute for Suicide Research and Prevention, Griffith University, Mt Gravatt, Queensland.

Objective: Sun safety is crucial for preventing skin cancer. This study evaluated a school-based intervention based on the Theory of Planned Behaviour (TPB) which aimed to encourage sun-protective behaviour among adolescents.

Methods: Secondary school students (N=382; 61. Read More

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December 2018
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Skin tape stripping: which layers of the epidermis are removed?

Contact Dermatitis 2018 Dec 15. Epub 2018 Dec 15.

The National Allergy Research Centre, Department of Dermatology and Allergy, Copenhagen University Hospital Herlev-Gentofte, Hellerup, Denmark.

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December 2018
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Anaphylactic reaction caused by skin contact with disinfectant chloramine-T.

Contact Dermatitis 2018 Dec 15. Epub 2018 Dec 15.

Department of Dermatology, University of Groningen, University Medical Center Groningen, The Netherlands.

Chloramine-T (CAS no. 7080-50-4, syn. sodium p-toluenesulfonchloramide) is a crystalline powder on a chlorine basis, commonly used as a sterilizer, antiseptic, disinfectant and chemical reagent. Read More

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December 2018
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Follicular Induction And CK20+ Merkel Cells Overlying Cutaneous Focal Mucinosis.

J Cutan Pathol 2018 Dec 14. Epub 2018 Dec 14.

Hospital of the University of Pennsvylvania, Philadelphia, PA.

Background: Cutaneous focal mucinosis (CFM), or focal dermal mucinosis, is a benign reactive process categorized as a primary mucinosis. Skin biopsy is essential for diagnosis, as the clinical appearance is often non-specific. Follicular induction is a phenomenon whereby the epidermis is induced by an underlying process to form primitive or mature hair follicles, and is commonly seen overlying dermatofibromas. Read More

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December 2018
2 Reads

Lichen planus: altered AIM2 and NLRP1 expression in skin lesions and defective activation in peripheral blood mononuclear cells.

Clin Exp Dermatol 2018 Dec 14. Epub 2018 Dec 14.

Laboratory of Investigation in Medicine, LIM-56, Department of Dermatology, Tropical Medicine Institute of São Paulo, University of São Paulo Medical School, São Paulo, Brazil.

Background: Lichen planus (LP) is an inflammatory skin disease with unknown aetiology. Activation by pathogen-associated molecular patterns or environmental stimuli may activate some components of inflammasomes that contribute to the inflammatory process in LP lesions.

Aim: To characterize the inflammasomes in skin lesions and peripheral blood mononuclear cells (PBMCs) of patients with LP under Toll-like receptor (TLR) activation. Read More

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December 2018
3 Reads

Tissue Concentrations of Zinc, Iron, Copper, and Magnesium During the Phases of Full Thickness Wound Healing in a Rodent Model.

Biol Trace Elem Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Plastic, Aesthetic, Hand and Reconstructive Surgery, Hannover Medical School, Hannover, Germany.

Wound healing is a complex orchestration of processes involving cell proliferation, migration, differentiation, anabolism, and catabolism in order to restore skin continuity. Within these processes, elements such as metallic ions are involved due to their implications in cell behavior and enzymatic activity regulation. This study analyzed the kinetics of zinc, iron, copper and magnesium concentrations in a full thickness open wound rat model over 14 days. Read More

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December 2018
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Effect and Mechanism of Ganoderma lucidum Polysaccharides on Human Fibroblasts and Skin Wound Healing in Mice.

Chin J Integr Med 2018 Dec 15. Epub 2018 Dec 15.

Department of Plastic Surgery, the Third Xiangya Hospital of Central South University, Changsha, 410013, China.

Objective: To investigate the effects of Ganoderma lucidum polysaccharides (GL-PS) on human fifi broblasts and skin wound healing in Kunming male mice and to explore the putative molecular mechanism.

Methods: Primary human skin fifi broblasts were cultured. The viability of fifi broblasts treated with 0, 10, 20, 40, 80, and 160 μg/mL of GL-PS, respectively were detected by 3-4,5-dimethyl-2-thiazolyl-2,5-diphenyl-2-Htetrazolium bromide (MTT). Read More

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December 2018
2 Reads

Cornification of nail keratinocytes requires autophagy for bulk degradation of intracellular proteins while sparing components of the cytoskeleton.

Apoptosis 2018 Dec 14. Epub 2018 Dec 14.

Research Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Lazarettgasse 14, 1090, Vienna, Austria.

Epidermal keratinocytes undergo cornification to form the cellular building blocks of hard skin appendages such as nails and the protective layer on the surface of the skin. Cornification requires the cross-linking of structural proteins and the removal of other cellular components to form mechanically rigid and inert corneocytes. Autophagy has been proposed to contribute to this intracellular remodelling process, but its molecular targets in keratinocytes, if any, have remained elusive. Read More

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December 2018
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Use of the myocutaneous serratus anterior free flap for reconstruction after salvage glossectomy.

Eur Arch Otorhinolaryngol 2018 Dec 14. Epub 2018 Dec 14.

Institute of Head and Neck Diseases, Evangelical Hospital Vienna, Vienna, Austria.

Purpose: To describe the use of a myocutaneous serratus anterior free flap (SAFF) for tongue reconstruction after salvage subtotal (STG) and total glossectomy (TG).

Methods: In this prospective case series, seven patients underwent salvage STG or TG and reconstruction with a myocutaneous SAFF between 10/2015 and 02/2017. Functional and oncologic outcomes were prospectively evaluated. Read More

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December 2018
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The Use of Platelet-Rich Plasma in Aesthetic and Regenerative Medicine: A Comprehensive Review.

Aesthetic Plast Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Molecular Medicine and Genetics, Research Center for Molecular Medicine, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Introduction: In recent years, platelet-rich plasma (PRP) has emerged as a promising autologous biological treatment modality for the use in aesthetic and regenerative medicine. PRP is a high concentration of platelets derived from whole blood which is isolated by centrifugation to separate and concentrate platelet-containing plasma from red blood cells. PRP comprises hundreds of bioactive proteins, including growth factors, peptides, and cytokines that stimulate healing of skin and soft tissues. Read More

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December 2018
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Ex vivo conditioning with IL-12 protects tumor-infiltrating CD8 T cells from negative regulation by local IFN-γ.

Cancer Immunol Immunother 2018 Dec 14. Epub 2018 Dec 14.

Department of Inflammation and Immunity, Cleveland Clinic, Lerner Research Institute, 9500 Euclid Avenue NE40, Cleveland, OH, 44195, USA.

Optimal ex vivo expansion protocols for adoptive cell therapy (ACT) must yield T cells able to effectively home to tumors and survive the inhospitable conditions of the tumor microenvironment (TME), while simultaneously exerting persistent anti-tumor effector functions. Our previous work has shown that ex vivo activation in the presence of IL-12 can induce optimal expansion of murine CD8 T cells, thus resulting in significant tumor regression after ACT mostly via sustained secretion of IFN-γ. In this report, we further elucidate the mechanism of this potency, showing that IL-12 additionally counteracts the negative regulatory effects of autocrine IFN-γ. Read More

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December 2018
2 Reads

Juvenile dermatomyositis with IgA nephropathy: case-based review.

Rheumatol Int 2018 Dec 14. Epub 2018 Dec 14.

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Juvenile dermatomyositis (JDM) is the most common childhood idiopathic inflammatory myopathy (IIM). It is characterized by the classic skin rash in the form of Gottron papules and heliotrope rash, and symmetric proximal muscle weakness. Renal involvement in JDM is rare which includes acute kidney injury and glomerulonephritis. Read More

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December 2018
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Pediatric percutaneous renal biopsies: comparison of complications between real-time ultrasound guidance and pre-procedure ultrasound-aided skin-marking techniques.

Pediatr Radiol 2018 Dec 14. Epub 2018 Dec 14.

Department of Radiology, Texas Children's Hospital, 6701 Fannin St., #470, Houston, TX, 77030, USA.

Background: Percutaneous renal biopsy is a commonly performed procedure that guides decision-making for children with renal disease.

Objective: To compare complications from renal biopsies using real-time ultrasound (US) guidance versus pre-procedure US-aided skin-marking in children.

Materials And Methods: We conducted a priori power analysis using a risk-adjusted model, which indicated we needed a sample size of 643-714 procedures (effect size: 0. Read More

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December 2018
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Essential oils sensory quality and their bioactivity against the mosquito Aedes albopictus.

Sci Rep 2018 Dec 14;8(1):17857. Epub 2018 Dec 14.

Department of Agriculture, Food and Environment - University of Pisa, Pisa, Italy.

Repellents are a main tool to prevent the outbreak of mosquito-borne diseases that represents a threat for millions of people worldwide. Plant-based products are very promising, low-toxic and eco-friendly alternative to synthetic repellents. Here, we performed an olfactory screening of the essential oils (EOs) of Artemisia verlotiorum Lamotte (Asteraceae), Lavandula dentata L. Read More

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December 2018
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Sphingoid bases of dietary ceramide 2-aminoethylphosphonate, a marine sphingolipid, absorb into lymph in rats.

J Lipid Res 2018 Dec 14. Epub 2018 Dec 14.

Kyoto University, Japan;

Various functions of dietary sphingolipids have been reported; however, little is known about marine sphingolipids. Ceramide 2-aminoethylphosphonate (CAEP), an abundant sphingolipid in marine molluscs, frequently has a unique triene-type of sphingoid base (2-amino-9-methyl-4,8,10-octadecatriene-1,3-diol, or d19:3). We previously reported that dietary CAEP prepared from the skin of squid was digested in the intestinal mucosa of mice via ceramides to yield free sphingoid bases. Read More

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December 2018
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study: protocol for a stepped-wedge cluster randomised trial to compare access to care for a mobile app versus a workstation-based store-and-forward teledermatology process.

BMJ Open 2018 Dec 14;8(12):e022218. Epub 2018 Dec 14.

US Department of Veterans Affairs, Center for Access Policy, Evaluation and Research, Boston, Massachusetts, USA.

Introduction: Teledermatology has emerged as an important strategy to enhance access to high-quality skin care. is a provider-facing, web-based mobile app designed to integrate into the existing teledermatology workflow in the US Veterans Health Administration (VHA). In this study, we will conduct a systematic evaluation of on access outcomes in VHA facilities using a pragmatic trial guided by clinical and operational leaders. Read More

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December 2018
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-(2-(dimethylamino)ethyl)-4-F-fluorobenzamide: A Novel Molecular Probe for High-Contrast PET Imaging of Malignant Melanoma.

J Nucl Med 2018 Dec 14. Epub 2018 Dec 14.

Chonnam National University Medical School, Korea, Republic of.

Malignant melanoma is a very aggressive and serious form of skin cancer, with prognosis and treatment outcome depending heavily on the clinical stage of the disease at the time of diagnosis. Here, we synthesized a novel F-labeled benzamide derivative to target melanoma, and then evaluated its biological characteristics in small animal models. : -(2-(dimethylamino)ethyl)-4-F-fluorobenzamide (F-DMFB) was synthesized by reaction of -succinimidyl 4-F-fluorobenzoate with ,-dimethylethylenediamine. Read More

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December 2018
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Extreme Adhesion Activity of Amyloid Fibrils Induces Subcutaneous Insulin Resistance.

Diabetes 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Insulin-derived amyloidoma, also called an insulin ball, is a skin-related complication of insulin therapy caused by repeated insulin injections at the same site, where native folded insulin changes into amyloid fibrils and forms a mass with a granulomatous reaction. Insulin-derived amyloidoma is a clinically important condition because of its association with subcutaneous insulin resistance, but the precise effect and mechanism of the insulin absorption impairment have not been clarified. We generated insulin-derived amyloidomas in mouse skin, with the amyloidomas large enough to perform insulin tolerance tests in the mass by repeated injections of highly concentrated insulin amyloid fibrils. Read More

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December 2018
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Oral mucosa pressure ulcers in intensive care unit patients: A preliminary observational study of incidence and risk factors.

J Tissue Viability 2018 Dec 5. Epub 2018 Dec 5.

Urology Ward, Pusan National University Hospital, Busan, South Korea.

Purpose: This study examined the incidence of oral mucosa pressure ulcers (PUs) in intensive care unit (ICU) patients and the relationship between biomechanical and physiological variables in onset of PUs.

Methods: A prospective observational descriptive study design was used. We recruited patients over 18 years of age with endotracheal tube (ETT) insertion in three ICUs in a tertiary hospital in Korea. Read More

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December 2018
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Cold evoked potentials: Acquisition from cervical dermatomes.

Neurophysiol Clin 2018 Dec 11. Epub 2018 Dec 11.

Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Forchstrasse 340, 8008 Zurich, Switzerland. Electronic address:

Introduction: Cold evoked potentials (CEPs) represent a novel technique to assess the integrity of cold-specific pathways within the somatosensory system. So far an objective assessment of these pathways has not been implemented into the clinical routine. Specifically, CEPs may help to elucidate the pathophysiological underpinnings of altered cold processing in neurological diseases. Read More

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December 2018
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[Sweet's syndrome induced by pegfilgrastim during a myelodysplastic syndrome AREB2: A case report].

Rev Med Interne 2018 Dec 11. Epub 2018 Dec 11.

Service d'hématologie-oncologie, CHU Brugmann, 4, place Arthur Van Gehuchten, 1020 Bruxelles, Belgique.

Introduction: Sweet's syndrome is an acute neutrophilic dermatosis characterized by abrupt onset of skin lesions accompanied by fever, arthralgia, leukocytosis and diffuse neutrophilic infiltration of the dermis, as well as an excellent response to corticosteroid therapy.

Case Report: A 46-year-old patient with myelodysplastic syndrome was admitted for chemotherapy. On the eighth day of chemotherapy, he received a single dose of pegfilgrastim. Read More

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December 2018
2 Reads

[Occupational cancers: Risks and prevention].

Bull Cancer 2018 Dec 11. Epub 2018 Dec 11.

Université Bordeaux, Inserm UMR 1219, équipe ÉPICENE, ISPED case 11, 146, rue Léo-Saignat, 33076 Bordeaux cedex, France; CHU de Bordeaux, service de médecine du travail et pathologie professionnelle, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France.

Since 2008, cancer became the first cause of death in France, exceeding cardiovascular diseases. The part of occupational cancers is close to 5% of all cancers but may still be widely underestimated. The detection of occupational cancer risk factors remains complicated. Read More

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December 2018
1 Read

Unilateral subcutaneous fibroma in the distal femoral region of a 5-year-old Nooitgedacht mare.

J S Afr Vet Assoc 2018 Dec 5;89(0):e1-e4. Epub 2018 Dec 5.

Department of Companion Animal Clinical Studies, University of Pretoria.

A non-ossified unilateral subcutaneous fibroma was diagnosed in the distal femoral region of a 5-year-old Nooitgedacht mare. Histopathological examination of the excised mass revealed long interweaving bundles of semi-mature monotonous collagenous connective tissue with fusiform nuclei without mitotic figures. The mare made an uneventful recovery following surgical removal of the neoplasm. Read More

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December 2018
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Feather and skin development of ostriches Struthio camelus.

J S Afr Vet Assoc 2018 Dec 5;89(0):e1-e5. Epub 2018 Dec 5.

Directorate for Animal Sciences, Western Cape Department of Agriculture.

Information on feather and skin growth is important for the development of mathematical optimisation nutritional models for ostriches. Ostriches (n = 65) were subjected to a four-stage formulated growth diet programme (pre-starter, starter, grower and finisher), with declining protein and energy content. Nine birds were weighed, stunned, exsanguinated, defeathered, skinned and eviscerated at 1, 54, 84, 104, 115, 132 and 287 days of age. Read More

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December 2018
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Association between Spatial Access to Food Outlets, Frequency of Grocery Shopping, and Objectively-Assessed and Self-Reported Fruit and Vegetable Consumption.

Nutrients 2018 Dec 13;10(12). Epub 2018 Dec 13.

Department of Dietetics and Human Nutrition, School of Human Environmental Sciences, University of Kentucky, Lexington, KY 40506, USA.

Because supermarkets are a critical part of the community food environment, the purpose of this paper is to examine the association between accessibility to the supermarket where participants were surveyed, frequency of shopping at the supermarket, and self-reported and objectively-assessed fruit and vegetable consumption. Accessibility was assessed using Geographic Information Systems (GIS) measured distance and multiple versions of the modified Retail Food Environment Index (mRFEI), including a localized road network buffer version. Frequency of shopping was assessed using self-report. Read More

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December 2018
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Evaluation of the Novel Synthetic Tyrosinase Inhibitor ()-3-(3-bromo-4-hydroxybenzylidene)thiochroman-4-one (MHY1498) and .

Molecules 2018 Dec 13;23(12). Epub 2018 Dec 13.

College of Pharmacy, Pusan National University, Busan 46241, Korea.

Tyrosinase is a key enzyme in melanin synthesis, catalyzing the initial rate-limiting steps of melanin synthesis. Abnormal and excessive melanin synthesis is the primary cause of serious skin disorders including melasma, senile lentigo, freckles, and age spots. In attempts to find potent and safe tyrosinase inhibitors, we designed and synthesized a novel compound, ()-3-(3-bromo-4-hydroxybenzylidene)thiochroman-4-one (MHY1498), and evaluated its tyrosinase inhibitory activity and . Read More

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December 2018
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Chitosan/Poly(vinylpyrrolidone) Matrices Obtained by Gamma-Irradiation for Skin Scaffolds: Characterization and Preliminary Cell Response Studies.

Materials (Basel) 2018 Dec 13;11(12). Epub 2018 Dec 13.

Centro de Ciências e Tecnologias Nucleares (C2TN), Instituto Superior Técnico, Universidade de Lisboa, Estrada Nacional 10, 2695-066 Bobadela, LRS, Portugal.

Several studies have shown that chitosan possesses characteristics favorable for promoting dermal regeneration and accelerated wound healing. In this work we have reported the work that has been done on the development and characterization of biocompatible and biodegradable chitosan based matrices to be used as skin scaffolds. Poly(vinylpyrrrolidone) (PVP) was used as copolymer and a two steps methodology of freeze-drying and gamma irradiation was used to obtain the porous matrices. Read More

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December 2018
2 Reads

HPLC profiling of Mimosa pudica polyphenols and their non-invasive biophysical investigations for anti-dermatoheliotic and skin reinstating potential.

Biomed Pharmacother 2019 Jan 5;109:865-875. Epub 2018 Nov 5.

School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, The University of Dublin, Dublin 2, Ireland.

Plant-derived polyphenols are known to have promising biological activities including antioxidant and antityrosinase and may be a potential candidate for anti-dermatoheliotic remedy. The present study was performed to investigate the polyphenolic contents of Mimosa pudica (MP) seed extract and its anti-dermatoheliotic potential using non-invasive biophysical techniques after developing a stable topical emulgel formulation. Moreover, its in-vitro cytotoxicity was also evaluated using normal Human keratinocytes (HaCat cells) to rule out any cellular incompatibility. Read More

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January 2019
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Metformin increases antitumor activity of MEK inhibitor binimetinib in 2D and 3D models of human metastatic melanoma cells.

Biomed Pharmacother 2019 Jan 5;109:2548-2560. Epub 2018 Dec 5.

Department of Experimental Diagnostic and Tumor Therapy N.N. Blokhin National Medical Research Center for Oncology, 115478, 24 Kashirskoe shosse, Moscow, Russia. Electronic address:

Melanoma is one of the most aggressive and treatment-resistant tumors that responsible for majority of skin-cancer related deaths. Here we propose a combination of MEK inhibitor binimetinib with metformin as a promising therapy against human melanoma cells in vitro, including BRAF -mutated A375, Mel Z, and Mel IL cells, and NRAS-mutated Mel MTP and Mel Me cells. Additionally, we obtained two close to clinical practice models of melanoma progression. Read More

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January 2019
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Rutaecarpine inhibited imiquimod-induced psoriasis-like dermatitis via inhibiting the NF-κB and TLR7 pathways in mice.

Biomed Pharmacother 2019 Jan 26;109:1876-1883. Epub 2018 Nov 26.

Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital, Central South University, Changsha 410011, China.

Psoriasis is a chronic, immune-mediated inflammatory skin disease. As psoriasis rarely occurs in nonhuman animals, the lack of an ideal animal model reflecting the histopathological and molecular immunological characteristics of psoriasis remains an urgent issue. In the present study, an imiquimod-induced psoriasis-like dermatitis mouse model was constructed under natural immune conditions and verified by evaluations of the Psoriasis Area and Severity Index (PASI) score and Baker score, H&E staining, immunohistochemical examination of the CD3 and Gr1 levels, measurement of plasmacytoid dendritic cell- (pDC) and Th17-associated cytokine levels, and evaluation of p65 phosphorylation and TLR7 expression. Read More

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January 2019
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A review on mechanism of action, resistance, synergism, and clinical implications of mupirocin against Staphylococcus aureus.

Biomed Pharmacother 2019 Jan 26;109:1809-1818. Epub 2018 Nov 26.

Department of Microbiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Mupirocin (MUP), bactroban, or pseudomonic acid is a natural crotonic acid derivative drug extracted from Pseudomonas fluorescens which is produced by modular polyketide synthases. This antibiotic has a unique chemical structure and mechanism of action. It is a mixture of A-D pseudomonic acids and inhibits protein synthesis through binding to bacterial isoleucyl-tRNA synthetase. Read More

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January 2019
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A CCR4 antagonist ameliorates atopic dermatitis-like skin lesions induced by dibutyl phthalate and a hydrogel patch containing ovalbumin.

Biomed Pharmacother 2019 Jan 13;109:1437-1444. Epub 2018 Nov 13.

Division of Chemotherapy, Kindai University, Faculty of Pharmacy, Kowakae 3-4-1, Higashi-Osaka, Osaka 577-8502, Japan. Electronic address:

CCR4 is a chemokine receptor highly expressed by Th2 cells, and regarded as a potential therapeutic target for atopic dermatitis (AD). CCL17 and CCL22 are the CCR4 ligands, and thymic stromal lymphopoietin (TSLP) is shown to promote the expression of CCL17 and CCL22 by dendritic cells. Here, by using dibutyl phthalate (DBP), a TSLP inducer, and a hydrogel patch as a transcutaneous delivery device for ovalbumin, we developed a novel murine AD model and investigated the effect of Compound 22, a CCR4 antagonist. Read More

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January 2019
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Potential phytochemicals in the fight against skin cancer: Current landscape and future perspectives.

Biomed Pharmacother 2019 Jan 12;109:1381-1393. Epub 2018 Nov 12.

Department of Chemistry and Chemical Engineering, SBA School of Science and Engineering, Lahore University of Management Sciences (LUMS), DHA, Lahore, Pakistan.

Skin cancer is a life threatening disease and their prevalence and risk has been increasing over the past three decades causing significant loss to human health worldwide. Mostly skin cancer has developed resistance against chemotherapy and radiotherapy. Therefore, development of novel, cost effective and efficient treatment methods are needed. Read More

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January 2019
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Zengye decoction induces alterations to metabolically active gut microbiota in aged constipated rats.

Biomed Pharmacother 2019 Jan 12;109:1361-1371. Epub 2018 Nov 12.

School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou, 510006, PR China; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, PR China. Electronic address:

Zengye decoction (ZYD), a traditional Chinese medicinal formula, has been used in the treatment of various chronic diseases, such as constipation and skin dryness syndrome. Clinically, the specific mechanisms and targets of ZYD for treating disease remain unclear. The present study was undertaken to investigate the effects of ZYD on the gut microbiota and host metabolites in aged constipated rats and the relationship between the intestinal microbiota and the host. Read More

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January 2019
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Microneedles: A smart approach and increasing potential for transdermal drug delivery system.

Biomed Pharmacother 2019 Jan 9;109:1249-1258. Epub 2018 Nov 9.

Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, 2007, Australia; School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, 2308, Australia; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, Lot 1 Kookaburra Circuit, New Lambton Heights, Newcastle, NSW 2305, Australia.

The most widely used methods for transdermal administration of the drugs are hypodermic needles, topical creams, and transdermal patches. The effect of most of the therapeutic agents is limited due to the stratum corneum layer of the skin, which serves as a barrier for the molecules and thus only a few molecules are able to reach the site of action. A new form of delivery system called the microneedles helps to enhance the delivery of the drug through this route and overcoming the various problems associated with the conventional formulations. Read More

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January 2019
2 Reads

Differential diagnosis.

Authors:
Yoichi Nakamura

Nihon Rinsho 2016 Oct;74(10):1650-1657

The points for differential diagnosis of asthma attack and other diseases are as follows. Acute heart failure (image analysis, BNP), hyperventilation syndrome (limbs numbness, low PaCO2), vocal cord dysfunction (stridor in the neck, normal SpO2), COPD exacerbation (smoking history, image analysis), pulmonary thromboembolism (contrasting CT, elevated D-dimer), spontaneous pneumothorax (chest pain, image analysis), large airway disease (inspi- ratory stridor, image analysis). Examinations for diagnosis of bronchial asthma in stable phase are respiratory function tests, increased eosinophils in sputum, FeNO, serum periostin and allergological examination (specific IgE, skin test). Read More

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October 2016
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Hormonal physiology of childbearing: evidence and implications for women, babies and maternity care.

Authors:
Alys Einion

Pract Midwife 2017 Apr;20(4):31-34

Report review runs alongside Guideline commentary and the other evidence series articles, examining local, national and international reports that have implications directly or indirectly for midwives. It helps readers to understand what reports mean for midwifery practice and to place report recommendations into context. As with all our evidence series articles, report reviews support you to critique recommendations and have implications for your own practice. Read More

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April 2017
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Premature diagnosis of calciphylaxis without pathological indications finally diagnosed as cutaneous small-vessel vasculitis: a post-mortem case report.

Nihon Jinzo Gakkai Shi 2017 ;59(2):85-91

A man in his fifties with diabetes had a past history of myocardial infarction and ventricular septal perforation. He underwent hemodialysis about a year ago and was taking amiodarone. He presented with sores and purpura on the lower limbs. Read More

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January 2017
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Plasma pentraxin 3 (PTX3) level is associated with the disease activity of microscopic polyangiitis (MPA).

Nihon Jinzo Gakkai Shi 2017 ;59(2):79-84

A 20-year-old woman, who was suffering from appetite loss, weight loss and livedo reticularis for one and half months, was referred to our hospital. On admission, laboratory studies demonstrated proteinuria (1.0 g/g Cr), hematuria (erythrocytes': 50 - 99/HPF), ,. Read More

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January 2017
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Pterostilbene and Its Glucoside Induce Type XVII Collagen Expression.

Nat Prod Commun 2017 Jan;12(1):85-86

The glycosylation of pterostilbene by cultured plant cells of Phytolacca americana gave pterostilbene 4'-O-β-D-glucoside. Both pterostilbene and its 4'-0-β-D- glucoside induced type XVII collagen expression in the EpiDermFT EFT-400 human skin cell model. Pterostilbene 4'-O-β-D-glucoside strongly induced type XVII collagen expression rather than pterostilbene. Read More

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January 2017
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Bioactive Glucitol-Core Containing Gallotannins and other Phytochemicals from Silver Maple (Acer saccharinum) Leaves.

Nat Prod Commun 2017 Jan;12(1):83-84

In the course of our group's investigation of members of the maple (Acer) genus, a series of glucitol-core containing gallotannins (GCGs) were-isolated and identified (by NMR and HREISMS). Among higher plants, only certain maple species are known to produce GCGs, compounds with potential nutraceutical and cosmetic applications due to their reported antioxidant, antidiabetic, anti-α-glucosidase, anti-glycation, anticancer, and skin. health promoting effects. Read More

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January 2017
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A Pilot Study on the Physiological Effects of Three Essential Oils in Humans.

Nat Prod Commun 2016 Oct;11(10):1561-1564

In the present study, the physiological effects on 32 humans exposed to experimental stress provoked by inhalation of the essential oils of East Indian sandalwood (Santalum album L.), Western Australian sandalwood (Santalum spicatum R.Br. Read More

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October 2016
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Low dose of aPCC after the initial treatment in acquired haemophilia A is useful to reduce bleeding relapses: Data from the FAIR registry.

Thromb Res 2018 Dec 6;174:24-26. Epub 2018 Dec 6.

Haemophilia and Thrombosis Centre, S.Giovanni Bosco Hospital of Naples, Italy.

Background: Bypassing agents are the first line therapy in patients with acquired haemophilia A (AHA). Activated prothrombin complex concentrate (aPCC) proved to be effective as initial treatment, but 20% of patients (pts) had relapses. aPCC as short-term prophylaxis to reduce subsequent bleeds is still not clear. Read More

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December 2018
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