765,302 results match your criteria Skin & Allergy News[Journal]


Side Effects of Frequently Used Antihypertensive Drugs on Wound Healing in vitro.

Skin Pharmacol Physiol 2019 Apr 24;32(3):162-172. Epub 2019 Apr 24.

Institute for Translational Wound Research, Centre for Biomedical Education and Research (ZBAF), Witten/Herdecke University, Witten, Germany.

Background: The number of patients who has a daily intake of antihypertensive drugs is rising, due to an also rising prevalence of lifestyle diseases. Interestingly, knowledge about effects of these drugs in terms of wound healing is low.

Objective: Based on a few differing studies, the idea arose that antihypertensives may have side effects on wound healing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000499433DOI Listing
April 2019
1 Read

Inspiratory and Expiratory Flow Changes, Voice Symptoms and Laryngeal Findings during Histamine Challenge Tests.

Folia Phoniatr Logop 2019 Apr 24:1-7. Epub 2019 Apr 24.

Department of Otorhinolaryngology and Phoniatrics, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Objective: The aim of this study was to analyse the associations between the spirometry parameter changes in relation to laryngeal finding changes and self-reported voice and throat symptom changes among patients undergoing a histamine challenge test.

Patients And Methods: Thirty adult patients with a chronic cough underwent a histamine challenge test. Videolaryngostroboscopy and voice and throat symptoms were assessed using a visual analogue scale immediately before and after the challenge test. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495783DOI Listing

Systemic Pseudohypoaldosteronism Type 1 due to 3 Novel Mutations in SCNN1Aand SCNN1BGenes.

Horm Res Paediatr 2019 Apr 24:1-11. Epub 2019 Apr 24.

Department of Paediatric Endocrinology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Objective: The systemic form of pseudohypoaldosteronism type 1 (PHA1) is an autosomal recessive disorder characterized by defective sodium transport in multi-organ systems. Mutations in the genes encoding the amiloride-sensitive epithelial sodium channel, ENaC, account for genetic causes of systemic PHA1. We describe systemic PHA1 due to 4 novel variants detected in SCNN1A and SCNN1B in 3 cases from 3 unrelated consanguineous families. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000498860DOI Listing

Activation of liver x receptors prevents the spinal LTP induced by skin/muscle retraction in the thigh via SIRT1/NF-Κb pathway.

Neurochem Int 2019 Apr 21. Epub 2019 Apr 21.

Department of Physiology and Pain Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, PR China; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, Guangdong, PR China. Electronic address:

It has been reported that skin/muscle incision and retraction (SMIR) in the thigh, produces mechanical allodynia in the hind paw, far from the site of incision/retraction. The mechanical allodynia lasts about 22 days, indicating chronic post-operative pain develops. The precise mechanisms, however, are largely unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2019.04.002DOI Listing

Scissor haemorrhoidectomy under perineal anaesthetic infiltration as a day case procedure - video vignette.

Colorectal Dis 2019 Apr 24. Epub 2019 Apr 24.

Departament of Surgical oncology, Institute of Oncology, Vilnius University, Clinic of Internal, Family Medicine and Oncology, Faculty of Medicine, Vilnius, Lithuania.

Hemorrhoids are common anorectal disease [1]. Patients with Grade III-IV prolapsed hemorrhoids or after failed conservative are considered for excisional hemorrhoidectomy. Surgical technique At our department all patients with Grade III or IV symptomatic hemorrhoids undergo closed (as described by Fergusson) scissor hemorrhoidectomy under perineal anesthetic infiltration [2], with removal of the two classical piles at 3 and 11. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/codi.14656DOI Listing

Plasma pharmacokinetic profile and efficacy of meloxicam administered subcutaneously and intramuscularly to sheep.

PLoS One 2019 24;14(4):e0215842. Epub 2019 Apr 24.

School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, Australia.

Plasma pharmacokinetic profiles and the anti-inflammatory efficacy of meloxicam were determined when administered subcutaneously (SC) or intramuscularly (IM) to sheep. Merino ewes were initially injected with 0.1 mL of oil of turpentine into a forelimb to induce inflammation, followed by either 1. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215842PLOS

CD34 defines melanocyte stem cell subpopulations with distinct regenerative properties.

PLoS Genet 2019 Apr 24;15(4):e1008034. Epub 2019 Apr 24.

Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.

Melanocyte stem cells (McSCs) are the undifferentiated melanocytic cells of the mammalian hair follicle (HF) responsible for recurrent generation of a large number of differentiated melanocytes during each HF cycle. HF McSCs reside in both the CD34+ bulge/lower permanent portion (LPP) and the CD34- secondary hair germ (SHG) regions of the HF during telogen. Using Dct-H2BGFP mice, we separate bulge/LPP and SHG McSCs using FACS with GFP and anti-CD34 to show that these two subsets of McSCs are functionally distinct. Read More

View Article

Download full-text PDF

Source
http://dx.plos.org/10.1371/journal.pgen.1008034
Publisher Site
http://dx.doi.org/10.1371/journal.pgen.1008034DOI Listing
April 2019
1 Read

Validation of the Spanish Version of the Beginning Breastfeeding Survey-Cumulative: A Follow-up Study.

J Hum Lact 2019 Apr 24:890334419840003. Epub 2019 Apr 24.

2 Department of Nursing, University of Alicante, Alicante, Spain.

Background: The Beginning Breastfeeding Survey-Cumulative (BBSC) is an instrument that assesses the overall maternal perception of breastfeeding effectiveness during the early postpartum period.

Research Aims: The aims of this study were to adapt and validate a Spanish version of the BBSC and provide new evidence regarding its validity.

Methods: A standard forward and back-translation process was used to obtain the Spanish version of the questionnaire (BBSC-E). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0890334419840003DOI Listing

Correlative SICM-FCM reveals changes in morphology and kinetics of endocytic pits induced by disease-associated mutations in dynamin.

FASEB J 2019 Apr 24:fj201802635R. Epub 2019 Apr 24.

Division of Experimental Medicine, Department of Medicine, Imperial College London, London, United Kingdom.

Dynamin 2 (DNM2) is a GTP-binding protein that controls endocytic vesicle scission and defines a whole class of dynamin-dependent endocytosis, including clathrin-mediated endocytosis by caveoli. It has been suggested that mutations in the gene, associated with 3 inherited diseases, disrupt endocytosis. However, how exactly mutations affect the nanoscale morphology of endocytic machinery has never been studied. Read More

View Article

Download full-text PDF

Source
https://www.fasebj.org/doi/10.1096/fj.201802635R
Publisher Site
http://dx.doi.org/10.1096/fj.201802635RDOI Listing
April 2019
1 Read

Laser Treatment of Skin of Color for Medical and Aesthetic Uses With a New 650-Microsecond Nd:YAG 1064nm Laser

J Drugs Dermatol 2019 Apr;18(4):s135-137

Individuals with skin of color are a rapidly growing portion of the cosmetic procedures market. There are unique challenges to treating skin conditions in skin of color patients. This article and roundtable discussion focus on the use of energy-based modalities, particularly a 650-microsecond 1064nm laser that delivers energy in a collimated beam. Read More

View Article

Download full-text PDF

Source

Open-label study assessing the efficacy and tolerability of topical skin care and sun protection alone and in combination with intense pulsed light therapy.

J Cosmet Dermatol 2019 Apr 24. Epub 2019 Apr 24.

The Pearl Dermatology, Houston, Texas.

Background: Intense pulsed light therapy (IPL) decreases facial erythema and telangiectasias associated with rosacea. Topical skin care products decrease facial erythema by the action of active ingredients and masking effects.

Objectives: To assess the efficacy and tolerability of combining a topical skin care regimen (TSCR) comprised of a multifunctional three-in-one facial cream and a mineral-based brush-on SPF50 powder sunscreen with a single IPL treatment for treating mild-to-severe facial redness associated with rosacea. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jocd.12952DOI Listing

The use of black salve for self-treatment of Basal Cell Carcinoma.

Clin Exp Dermatol 2019 Apr 24. Epub 2019 Apr 24.

Department of Dermatology, Royal Victoria Hospital, Belfast, United Kingdom.

BCC is the most common form of cancer in England and Wales and has an increasing incidence. Black salve is an alternative therapy widely available with reported benefits in skin cancer despite a lack of supporting evidence. We report two patients with resolution of clinical BCC following the use of black salve. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ced.13988DOI Listing

Folliculitis decalvans and lichen planopilaris phenotypic spectrum: A case series of bi-phasic clinical presentation and theories on pathogenesis.

Clin Exp Dermatol 2019 Apr 24. Epub 2019 Apr 24.

The Dermatology Centre, University of Manchester, Salford Royal NHS Foundation Trust, Stott Lane, Salford, Greater Manchester, M6 8HD, U.K.

We present a series of 13 patients with clinical and histological features of both folliculitis decalvans (FD) and lichen planopilaris (LPP), either concomitantly in the same patient, or sequentially as the clinical phenotype changed over time. This bi-phasic presentation of FD-LPP is not as uncommon as would be expected from the lack of description in literature. We discuss current theories about LPP and FD pathogenesis and speculate how abnormal immune responses may either predispose to secondary bacterial infection or be influenced by dysbiosis of the skin/hair follicle microbiome resulting in inflammation and permanent hair follicle damage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ced.13989DOI Listing

Xeroderma Pigmentosum in South Africa: Evidence for a prevalent founder effect.

Br J Dermatol 2019 Apr 24. Epub 2019 Apr 24.

National Reference Center for Rare Skin Disorders, CHU de Bordeaux, Bordeaux, France.

Xeroderma pigmentosum (XP) is a rare, autosomal, recessive disease caused by defective repair of UV-induced DNA lesions due to various genetic defects affecting genes involved in the nucleotide excision repair (NER) pathway. Seven complementation groups have been described and named XP-A to XP-G, (OMIM 278700, 610651, 278720, 278730, 278740, 278760, 278780) with an additional XP variant form due to a defect in translesion DNA synthesis (OMIM 278750). Clinical manifestations are caused by the cutaneous and mucosal hypersensitivity to UV exposure, which induces multiple precocious cancerous lesions and premature skin aging. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjd.18030DOI Listing

Benefits of Electronically Capturing Patient-Reported Outcomes in Dermatology for Patient Care.

Br J Dermatol 2019 Apr 24. Epub 2019 Apr 24.

Department of Population Health Sciences, University of Utah, Salt Lake City, UT.

An 18-year-old woman presented for a total body skin examination (TBSE) with a few benign-looking naevi on her abdomen. Her Skindex-16 Emotional subscore was the highest of any patient that day, indicating that she was very bothered by her skin condition. Upon further questioning, she expressed significant concern that these abdominal moles were melanoma, as her grandfather had recently died of melanoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjd.18027DOI Listing

Nevirapine in HIV maintenance therapy - can "old drugs" survive in current HIV management?

Swiss Med Wkly 2019 Apr 24;149:w20053. Epub 2019 Apr 24.

Cantonal Hospital St.Gallen, Department of Infectious Diseases and Hospital Epidemiology, St. Gallen, Switzerland / Children's Hospital of Eastern Switzerland, Department of Infectious Diseases and Hospital Epidemiology, St. Gallen, Switzerland.

Aims Of The Study: Nevirapine has an exceptional record for long-term tolerability with few side effects in human immunodeficiency virus (HIV) combined antiretroviral therapy (cART). Owing to relatively frequent hypersensitivity reactions (HSR) (15–25%) in the first 3 months after treatment initiation (especially in patients with a high CD4 count (>250/µl in women, >400/µl in men)), it is being used less and less. However, the rate of adverse events is lower when patients are already under suppressive cART. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4414/smw.2019.20053DOI Listing

Association of Duration and Type of Surgical Prophylaxis With Antimicrobial-Associated Adverse Events.

JAMA Surg 2019 Apr 24. Epub 2019 Apr 24.

Department of Medicine, VA Boston Healthcare System, Boston, Massachusetts.

Importance: The benefits of antimicrobial prophylaxis are limited to the first 24 hours postoperatively. Little is known about the harms associated with continuing antimicrobial prophylaxis after skin closure.

Objective: To characterize the association of type and duration of prophylaxis with surgical site infection (SSI), acute kidney injury (AKI), and Clostridium difficile infection. Read More

View Article

Download full-text PDF

Source
http://archsurg.jamanetwork.com/article.aspx?doi=10.1001/jam
Publisher Site
http://dx.doi.org/10.1001/jamasurg.2019.0569DOI Listing
April 2019
1 Read

Use of Platelet-Rich Plasma Injection for Rejuvenation of Photoaged Facial Skin?-Reply.

Authors:
Murad Alam

JAMA Dermatol 2019 Apr 24. Epub 2019 Apr 24.

Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamadermatol.2019.0363DOI Listing

Use of Platelet-Rich Plasma Injection for Rejuvenation of Photoaged Facial Skin?

JAMA Dermatol 2019 Apr 24. Epub 2019 Apr 24.

Infinity Family Medicine Clinic, Dubai, United Arab Emirates.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamadermatol.2019.0357DOI Listing

Computational neural network in melanocytic lesions diagnosis: artificial intelligence to improve diagnosis in dermatology?

Eur J Dermatol 2019 Apr;29(S1):4-7

Facolta di Medicina et Chirugia, UNIMORE Iniversita Degli Studi di Modena e Reggio Emilia, Modena, Italy.

Diagnosis in dermatology is largely based on contextual factors going far beyond the visual and dermoscopic inspection of a lesion. Diagnostic tools such as the different types of dermoscopy, confocal microscopy and optical coherence tomography (OCT) are available and all of these have shown their importance in improving the dermatologist's ability, especially in the diagnosis of skin cancer. Their use, however, remains limited and time consuming, and optimizing their practice appears to be difficult, requiring extensive pre-processing, lesion segmentation and extraction of domain-specific visual features before classification. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1684/ejd.2019.3538DOI Listing

The microbiome, a new target for ecobiology in dermatology.

Authors:
Brigitte Dréno

Eur J Dermatol 2019 Apr;29(S1):15-18

CHU Nantes-Hôtel-Dieu, UF dermato-cancérologie, Inserm U1232, CIC biothérapie Inserm 05031, place Alexis-Ricordeau, 44093 Nantes cedex 01, France.

The skin is the human body's largest organ colonised by a large community of microorganisms. The ecological community of microorganisms that are present on our body and of the body itself defines the human skin microbiome. Ecobiology is a new scientific approach that is based on the principle that the skin is an ever-evolving ecosystem which interacts with its environment and whose natural resources and mechanisms must be preserved. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1684/ejd.2019.3535DOI Listing

Automatic localization of anatomical regions in medical ultrasound images of rheumatoid arthritis using deep learning.

Proc Inst Mech Eng H 2019 Apr 24:954411919845747. Epub 2019 Apr 24.

3 Department of Biomedical Engineering, Vels Institute of Science, Technology and Advanced Studies, Chennai, India.

The pace of population aging is growing faster worldwide. The quality of life of the aging population is mostly affected by rheumatic diseases. With the increasing rate of rheumatoid arthritis in the aging population, technological advances in the field of automatic image processing and analysis have paved way for automatic detection and diagnosis of arthritis based on how the grade of the synovial region is designed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0954411919845747DOI Listing

Lizard Tail Extracts Exert Protective Effect Against Oxidative Stress-Induced Cellular Senescence in Human Fibroblasts.

J Med Food 2019 Apr 24. Epub 2019 Apr 24.

1 Department of Biological Science, Dong-A University, Busan, Korea.

Lizards are the evolutionary closest animals to humans among the self-renewable species. Recent reports show that lizard tail extracts (LTE) inhibit the proliferation and angiogenesis of cancer cells but do not show any toxicity against human fibroblast cells. Nevertheless, few scientific studies investigated the effects of LTE on the treatment of skin diseases, especially oxidative stress aging. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/jmf.2018.4369DOI Listing

Tissue resident T cell memory or how the magnificent seven are chilling in the bone.

Eur J Immunol 2019 Apr 24. Epub 2019 Apr 24.

Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Switzerland.

Following infection, tissue resident memory T cells (Trm) are thought to be left behind at sites of antigen encounter to protect affected tissues against subsequent reinfection. In this issue of the European Journal of Immunology, however, Pascutti et al. [Eur. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.20194820
Publisher Site
http://dx.doi.org/10.1002/eji.201948208DOI Listing
April 2019
1 Read

Abnormal expression of SIRTs in psoriasis: Decreased expression of SIRT 1-5 and increased expression of SIRT 6 and 7.

Int J Mol Med 2019 Apr 24. Epub 2019 Apr 24.

Department of Dermatology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China.

The prevalence of psoriasis is increasing, and poses a serious risk to human health and quality of life. Psoriasis, a chronic immune‑mediated skin disease with epidermal hyperkeratosis and parakeratosis, is associated with numerous complications, including metabolic syndromes that are regulated by sirtuins (SIRTs) via deacetylation. As they serve a necessary function in inflammation and metabolism, SIRTs are considered to link inflammation and metabolic syndrome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ijmm.2019.4173DOI Listing

Protective effects of tyndallized Lactobacillus acidophilus IDCC 3302 against UVB‑induced photodamage to epidermal keratinocytes cells.

Int J Mol Med 2019 Jun 10;43(6):2499-2506. Epub 2019 Apr 10.

Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea.

Photoaging is a consequence of chronic exposure to ultraviolet (UV) radiation and results in skin damage. In this study, whether tyndallizate of the probiotic bacterium Lactobacillus acidophilus IDCC 3302 (ACT 3302) can protect against UVB‑induced photodamage to the skin was investigated. For this, HaCaT keratinocytes were used as a model for skin photoaging. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ijmm.2019.4161DOI Listing

Afzelin suppresses proinflammatory responses in particulate matter-exposed human keratinocytes.

Int J Mol Med 2019 Jun 11;43(6):2516-2522. Epub 2019 Apr 11.

Department of Dermatology, Chung‑Ang University Hospital, Seoul 06973, Republic of Korea.

Particulate matter (PM), a widespread airborne contaminant, is a complex mixture of solid and liquid particles suspended in the air. Recent studies have demonstrated that PM induces oxidative stress and inflammatory reactions, and may cause certain skin diseases. Afzelin is a flavonoid isolated from Thesium chinense Turcz, which has anti‑inflammatory, anticancer and antibacterial properties. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ijmm.2019.4162DOI Listing

Sunbed Use Increases Cutaneous Squamous Cell Carcinoma Risk in Women: A Large-scale, Prospective Study in Sweden.

Acta Derm Venereol 2019 Apr 16. Epub 2019 Apr 16.

Department of Dermatology, Skåne University Hospital, Lasarettsgatan 15, SE-22241 Lund, Sweden.

The incidence of cutaneous squamous cell carcinoma has increased rapidly in Sweden in the past decades. Here, we present a prospective study of the Melanoma in Southern Sweden (MISS)-cohort, with 29,460 participating women in southern Sweden that investigates the risk factors for cutaneous squamous cell carcinoma. Data on the host and skin cancer risk factors were collected through questionnaires and then matched with the National Cancer Registry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2340/00015555-3198DOI Listing

Therapeutic Efficacy of Etretinate on Cutaneous-type Adult T-cell Leukemia-Lymphoma.

Acta Derm Venereol 2019 Apr 16. Epub 2019 Apr 16.

Department of Dermatology, Imamura General Hospital, 8900064 Kagoshima, Japan.

Cutaneous-type adult T-cell leukemia-lymphoma is treated with antiviral or skin-directed therapy. Medications that are used to treat skin lesions of cutaneous T-cell lymphomas are also used for the cutaneous-type adult T-cell leukemia-lymphoma. Etretinate, a synthetic retinoid, has been used for treating cutaneous T-cell lymphomas; however, its clinical effectiveness for the treatment of cutaneous-type adult T-cell leukemia-lymphoma has not been fully studied. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2340/00015555-3196DOI Listing

Male External Catheter in Adults: a glance at nursing care practice.

Rev Bras Enferm 2019 Mar-Apr;72(2):450-454. Epub 2019 Apr 18.

Universidade Federal do Paraná. Curitiba-PR, Brasil.

Objective: to describe the patients care in the use of the Male External Catheter in Adults in a clinical-surgical hospitalization unit.

Method: a cross-sectional study. Evaluation of 30 patients hospitalized in clinical-surgical units to collect items related to the specific care provided. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/0034-7167-2018-0327DOI Listing

Elaboration of an educational technology for ostomized patients: peristomal skin care.

Rev Bras Enferm 2019 Mar-Apr;72(2):427-434. Epub 2019 Apr 18.

Universidade do Estado do Pará. Belém-PA, Brasil.

Objective: to describe the elaboration of an educational technology to support orientations on peristomal skin care for ostomized patients.

Method: the research had a qualitative approach and used the Action-Research method; data was collected through the Focus Group technique, with eight ostomized patients. The data was analyzed through Thematic Content analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/0034-7167-2016-0024DOI Listing

Gecko toe pads inspired in situ switchable superhydrophobic shape memory adhesive film.

Nanoscale 2019 Apr 24. Epub 2019 Apr 24.

CAS Key Laboratory of Bio-inspired Materials and Interfacial Science, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.

Recently, smart adhesive superhydrophobic surfaces have attracted much attention. However, it is still a challenge to obtain a superhydrophobic surface with shape memory adhesive performance. Herein, inspired by the special back-scrolling/unfolding ability of gecko toe pads and corresponding tunable adhesion, we report such a film produced by sticking a layer of superhydrophobic pillar structured polyurethane (s-PU) onto a shape memory polyurethane-cellulose nanofiber (PU-CNF) substrate to mimic the hair-like skin structure and underlying muscle of the gecko toe pads, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c9nr00154aDOI Listing

[Synthesis of transdermal aloesin loaded zinc oxide nanoparticles and its inhibitory effect on the activity of tyrosinase].

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2019 Apr;36(2):254-259

School of Sports and Health Science, Tongren University, Tongren, Guizhou 554300,

Zinc oxide quantum dots (ZnO QDs) were synthesized by gel-sol method and employed as the transdermal aloesin (Alo) carriers. ZnO QDs were surface-functionalized with amino using aminopropyltriethoxysilane (APTES). Alo was covalently bonded on the surface of ZnO QDs via N,N'-carbonyldiimidazole to obtain Alo NPs, which were characterized by transmission electron microscope (TEM), dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FTIR) and thermal gravimetric analyzer (TGA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7507/1001-5515.201805018DOI Listing

Impact of skin biopsy on the management of acute graft-versus-host disease in a pediatric population.

Pediatr Dermatol 2019 Apr 23. Epub 2019 Apr 23.

Dermatology Program, Boston Children's Hospital, Boston, Massachusetts.

Background/objectives: Acute graft-versus-host disease (GVHD) of the skin is a common complication of hematopoietic stem cell transplantation (HSCT) but often represents a diagnostic challenge. The adult literature suggests that histopathology rarely dictates management decisions, but the clinical utility of skin biopsies in pediatric patients with suspected acute GVHD is unknown. The objective of this study was to determine the frequency with which skin biopsy leads to a definitive diagnosis of acute GVHD and changes the management of acute GVHD in the pediatric population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pde.13840DOI Listing
April 2019
1 Read

Letter: paradoxical skin eruptions during anti-TNF-α treatment of Crohn's disease.

Aliment Pharmacol Ther 2019 May;49(10):1369-1370

Department of Dermatology, Royal Victoria Hospital, Belfast, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apt.15244DOI Listing

Lateral pararectal versus transrectal stoma placement for prevention of parastomal herniation.

Cochrane Database Syst Rev 2019 Apr 24;4:CD009487. Epub 2019 Apr 24.

Department of Surgery, University Medical Centre Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, Mannheim, Baden-Württemberg, Germany, 68167.

Background: A parastomal hernia is defined as an incisional hernia related to a stoma, and belongs to the most common stoma-related complications. Many factors, which are considered to influence the incidence of parastomal herniation, have been investigated. However, it remains unclear whether the enterostomy should be placed through, or lateral to the rectus abdominis muscle, in order to prevent parastomal herniation and other important stoma complications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/14651858.CD009487.pub3DOI Listing

Cutaneous melanoma in patients from western Mexico: Clinical pathology characteristics and their relationship to prognosis.

Australas J Dermatol 2019 Apr 23. Epub 2019 Apr 23.

UMAE Hospital de Pediatria CMNO, IMSS, Guadalajara, Jalisco, Mexico.

Background/objective: Melanoma is the third most frequent malignant neoplasm in skin. The majority of information available comes from studies performed in Caucasian populations. Our objective was to investigate the clinico-pathological characteristics in Mexican patients with cutaneous melanoma and the relationship these characteristics had to prognosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ajd.13054DOI Listing

Inherited MC1R variants in melanoma patients are associated with better survival in females.

Br J Dermatol 2019 Apr 23. Epub 2019 Apr 23.

Dermatology Department, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain.

Background: Females have a better melanoma prognosis and fairer skin and hair colour. The presence of inherited MC1R variants has been associated with a better melanoma prognosis, but its interaction with sex is unknown.

Objectives: To evaluate the relationship between germline MC1R status and survival and determine any association with gender. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjd.18024DOI Listing

Budget Impact Analysis of Cancer Screening: A Methodological Review.

Appl Health Econ Health Policy 2019 Apr 24. Epub 2019 Apr 24.

Department of Public Health, Health Services Research and Health Technology Assessment, Institute of Public Health, Medical Decision Making and Health Technology Assessment, UMIT-University for Health Sciences, Medical Informatics and Technology, Eduard-Wallnoefer-Zentrum 1, 6060, Hall in Tyrol, Austria.

Background: Budget impact analyses (BIAs) describe changes in intervention- and disease-related costs of new technologies. Evidence on the quality of BIAs for cancer screening is lacking.

Objectives: We systematically reviewed the literature and methods to assess how closely BIA guidelines are followed when BIAs are performed for cancer-screening programs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40258-019-00475-6DOI Listing

Stem Cells Heterogeneity.

Adv Exp Med Biol 2019 ;1123:1-3

Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Adult endogenous stem cells are crucial to maintain organ homeostasis due to their particular capacity to originate more specialized cell populations in a coordinated manner based on the body necessity. Extensive studies in a variety of tissues have highlighted the importance of stem cells for the functioning of our organism, including the skin, intestine, stomach, skeletal muscle, bone marrow, and others. Although significant progress has been made in our understanding of stem cell biology, our knowledge about these cells still remains limited due to their complexity and their dynamics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-3-030-11096-3_1DOI Listing
January 2019

Clinical characteristics of Polish patients with ANCA-associated vasculitides-retrospective analysis of POLVAS registry.

Clin Rheumatol 2019 Apr 23. Epub 2019 Apr 23.

2nd Department of Internal Medicine, Faculty of Medicine, Jagiellonian University Medical College, ul. Skawińska 8, 31-066, Kraków, Poland.

Objective: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are rare small to medium-size vessel systemic diseases. As their clinical picture, organ involvement, and factors influencing outcome may differ between countries and geographical areas, we decided to describe a large cohort of Polish AAV patients coming from several referral centers-members of the Scientific Consortium of the Polish Vasculitis Registry (POLVAS).

Methods: We conducted a systematic multicenter retrospective study of adult patients diagnosed with AAV between Jan 1990 and Dec 2016 to analyze their clinical picture, organ involvement, and factors influencing outcome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10067-019-04538-wDOI Listing

Growth Trajectories of Peer Norms, Self-efficacy and Condom Use Behavior Among Sexually Active Chinese Men Who Have Sex with Men: Latent Class Analysis and Growth Mixture Modeling.

AIDS Behav 2019 Apr 23. Epub 2019 Apr 23.

Department of Epidemiology, School of Public Health, Shandong University, 44 West Wenhua Road, Jinan, 250012, Shandong, China.

Data from a randomized controlled trial in 2015 were used to estimate the growth trajectories of peer norms, self-efficacy, and condom use behavior, and to identify associated sociodemographic and behavioral factors among a sample of 804 Chinese men who have sex with men (MSM). Latent class analysis and growth mixture modeling were conducted using Mplus. Two growth trajectories were estimated for each outcome variable with good model fit. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10461-019-02515-7DOI Listing

[Case report on deviant care measures of a PICC line on a palliative patient].

Wien Med Wochenschr 2019 Apr 23. Epub 2019 Apr 23.

LKH Hartberg, Rotkreuzplatz 2, 8230, Hartberg, Österreich.

A PICC line is a peripheral, through a vein inserted, central venous catheter. There are different engineered stabilisation devices - some are with and some without a sutural. This is an individual case-report which only looks at one concrete fixing system with an adhesive plate (StatLock®). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10354-019-0696-9DOI Listing

Disposable Patterned Electroceutical Dressing (PED-10) Is Safe for Treatment of Open Clinical Chronic Wounds.

Adv Wound Care (New Rochelle) 2019 Apr 3;8(4):149-159. Epub 2019 Apr 3.

Department of Surgery, Indiana Center for Regenerative Medicine and Engineering (ICRME), Indiana University School of Medicine, Indianapolis, Indiana.

To evaluate if patterned electroceutical dressing (PED) is safe for human chronic wounds treatment as reported by wound care providers. This work reports a pilot feasibility study with the primary objective to determine physically observable effects of PED application on host tissue response from a safety evaluation point of view. For this pilot study, patients receiving a lower extremity amputation with at least one open wound on the part to be amputated were enrolled. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/wound.2018.0915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477589PMC

Thiosemicarbazones with tyrosinase inhibitory activity.

Medchemcomm 2019 Mar 5;10(3):378-389. Epub 2019 Feb 5.

Wrocław University of Science and Technology , Department of Bioorganic Chemistry , Wybrzeże Wyspiańskiego 27 , 50-370 , Wrocław , Poland . Email:

Tyrosinase plays an essential role in melanogenesis. Excess production of melanin can be a reason for hyperpigmentation skin disorders in mammals and enzymatic browning in plant-derived foods. Catalyzing the rate-limiting step of melanin synthesis, tyrosinase has become the most studied target for melanogenesis inhibition. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c9md00005dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457196PMC

α-Mangostin and Apigenin Induced Cell Cycle Arrest and Programmed Cell Death in SKOV-3 Ovarian Cancer Cells.

Toxicol Res 2019 Apr 15;35(2):167-179. Epub 2019 Apr 15.

Department of Biology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.

Ovarian cancer is the fifth main cause of pre-senescent death in women. Although chemotherapy is generally an efficient treatment, its side effects and the occurrence of chemotherapeutic resistance have prompted the need for alternative treatments. In this study, α-mangostin and apigenin were evaluated as possible anticancer alternatives to the chemotherapeutic drug doxorubicin, used herein as a positive control. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5487/TR.2019.35.2.167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467359PMC

Risk Assessment of Triclosan, a Cosmetic Preservative.

Toxicol Res 2019 Apr 15;35(2):137-154. Epub 2019 Apr 15.

College of Pharmacy, Dankook University, Cheonan, Korea.

Triclosan (TCS) is an antimicrobial compound used in consumer products. The purpose of current study was to examine toxicology and risk assessment of TCS based on available data. Acute toxicities of oral, transdermal and inhalation routes were low, and phototoxicity and neurotoxicity were not observed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5487/TR.2019.35.2.137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467355PMC

Risk Assessment of Ethylhexyl Dimethyl PABA in Cosmetics.

Toxicol Res 2019 Apr 15;35(2):131-136. Epub 2019 Apr 15.

Department of Bio Health Science, College of Natural Science, Changwon National University, Changwon, Korea.

Ethylhexyl dimethyl para-aminobenzoic acid (PABA) is an oily yellow liquid derivative of water-soluble PABA commonly used in sunscreen. Ethylhexyl dimethyl PABA is widely used as an ingredient in many cosmetics at an average concentration of 1.25% (0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5487/TR.2019.35.2.131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467356PMC

Risk Assessment of Drometrizole, a Cosmetic Ingredient used as an Ultraviolet Light Absorber.

Toxicol Res 2019 Apr 15;35(2):119-129. Epub 2019 Apr 15.

BK21Plus Team, College of Pharmacy, The Catholic University of Korea, Bucheon, Korea.

As the use of cosmetics has greatly increased in a daily life, safety issues with cosmetic ingredients have drawn an attention. Drometrizole [2-(2'-hydroxy-5'-methylphenyl)benzotriazole] is categorized as a sunscreen ingredient and is used in cosmetics and non-cosmetics as a UV light absorber. No significant toxicity has been observed in acute oral, inhalation, or dermal toxicity studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5487/TR.2019.35.2.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467354PMC

Risk Assessment of 5-Chloro-2-Methylisothiazol-3(2H)-One/2-Methylisothiazol-3(2H)-One (CMIT/MIT) Used as a Preservative in Cosmetics.

Toxicol Res 2019 Apr 15;35(2):103-117. Epub 2019 Apr 15.

Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Suwon, Korea.

The mixture of 5-chloro-2-methylisothiazol-3(2H)-one (CMIT) and 2-methylisothiazol-3(2H)-one (MIT), CMIT/MIT, is a preservative in cosmetics. CMIT/MIT is a highly effective preservative; however, it is also a commonly known skin sensitizer. Therefore, in the present study, a risk assessment for safety management of CMIT/MIT was conducted on products containing 0. Read More

View Article

Download full-text PDF

Source
http://www.toxicolres.org/journal/view.html?doi=10.5487/TR.2
Publisher Site
http://dx.doi.org/10.5487/TR.2019.35.2.103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467361PMC
April 2019
1 Read
  • Page 1 of 15307