284,618 results match your criteria Skeletal radiology[Journal]


Violence in the Early Bronze Age. Diagnosis of skull lesions using anthropological, taphonomic and scanning electron microscopy techniques.

Forensic Sci Med Pathol 2018 Dec 13. Epub 2018 Dec 13.

Department of Humanities, University of Ferrara, Ferrara, Italy.

In this paper we present the study of a skull belonging to a young male from the Italian Bronze Age showing three perimortem injuries on the frontal and parietal bones; the peculiarity of the frontal injury is represented by its singular shape, which may be indicative of the weapon that caused the lesion. The aim of the present study is to examine the traumatic evidence in relation to possible etiological factors, in order to attempt to establish if the lesion occurred peri or post-mortem, and to evaluate if these traumatic injuries could be interpreted as an evidence of interpersonal violence, by combining anthropological, taphonomic and ESEM investigations. The combination of multidisciplinary methods of study can provide important new insights into inter-personal violence. Read More

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December 2018

A review of filamin A mutations and associated interstitial lung disease.

Eur J Pediatr 2018 Dec 13. Epub 2018 Dec 13.

Clinical Genetics Department, Our Lady's Children's Hospital, Dublin, Ireland.

The filamin A gene (FLNA) on Xq28 encodes the filamin A protein. Mutation in FLNA causes a wide spectrum of disease including skeletal dysplasia, neuronal migration abnormality, cardiovascular malformation, intellectual disability and intestinal obstruction. Recently, childhood-onset interstitial lung disease associated with a range of FLNA mutations has been recognised and reported. Read More

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December 2018

Correction to: Cardiovascular, muscular, and skeletal adaptations to recreational team handball training: a randomized controlled trial with young adult untrained men.

Eur J Appl Physiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Sports Science and Clinical Biomechanics, SDU Sport and Health Sciences Cluster (SHSC), University of Southern Denmark, 3450, Odense, Denmark.

The author would like to correct the errors in the publication of the original article. The corrected details are given below for your reading. Read More

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December 2018

Painful right elbow mass.

Skeletal Radiol 2018 Dec 13. Epub 2018 Dec 13.

Radiology Department, Royal National Orthopaedic Hospital, Stanmore, UK.

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December 2018

Abdominal and Thigh Muscle Attenuation Is Associated With Visceral Fat and Age in Children and Adolescents With Obesity.

Glob Pediatr Health 2018 4;5:2333794X18817121. Epub 2018 Dec 4.

Mie University, Tsu, Mie, Japan.

. This study investigated relationships between adipose tissue deposition within skeletal muscle and morphological and biochemical variables in children with obesity. . Read More

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December 2018

The prevalence of malocclusion and orthodontic treatment need in Omani adolescent population.

J Orthod Sci 2018 15;7:21. Epub 2018 Nov 15.

Department of Orthodontics, Oman Dental College, Muscat, Oman.

Objective: To determine the prevalence of malocclusion and orthodontic treatment need in a sample of Omani adolescents aged 11-16 years.

Materials And Methods: The total sample included 854 adolescents with 387 boys and 467 girls between the age of 11 and 16 years with no previous orthodontic treatment history. The study design was cross-sectional. Read More

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November 2018

Association of vitamin D receptor ApaI gene polymorphism with osteoporosis susceptibility in postmenopausal Han Chinese women in Xinjiang.

Biomed Rep 2018 Dec 3;9(6):483-490. Epub 2018 Oct 3.

Department of Pathology, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang 832000, P.R. China.

Osteoporosis is a polygenic disorder and has been demonstrated to be associated with ~30 candidate genes, the majority of which have also been implicated in the regulation of bone mineral density (BMD). Vitamin D receptor (VDR) is the candidate gene that has been most extensively studied. Certain studies have reported that the VDR single nucleotide polymorphism ApaI is associated with the risk of osteoporosis in Caucasian and African women. Read More

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December 2018

The possible different roles of denosumab in prevention and cure breast cancer bone metastases: A 'hypothesis-generator' study from clinical practice.

Oncol Lett 2018 Dec 10;16(6):7195-7203. Epub 2018 Oct 10.

Medical Oncology, St. Salvatore Hospital, I-67100 L'Aquila, Italy.

The most frequent site of recurrence in breast cancer (BC) is the bone, particularly in patients with 'luminal-like' disease. Denosumab has been shown to prevent aromatase inhibitors (AIs) induced bone resorption in postmenopausal early BC patients and reduce skeletal-related events (SREs) in bone metastatic breast cancer (BMBC). A 'real life' analysis of 90 BMBC patients treated with denosumab was performed. Read More

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December 2018

The osteoarthritis-associated gene PAPSS2 promotes differentiation and matrix formation in ATDC5 chondrogenic cells.

Exp Ther Med 2018 Dec 11;16(6):5190-5200. Epub 2018 Oct 11.

Department of Orthopedic Surgery, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China.

3'-Phosphoadenosine 5'-phosphosulfate synthetase 2 (PAPSS2) has been shown to be important in the development of normal skeletal structure. The aim of the present study was to evaluate the role of PAPSS2 in the differentiation of chondrocytes as well as their mechanisms. Using RNA interference-mediated via a lentivirus and a retrovirus, PAPSS2 gene silence and overexpression in ATDC5 chondrogenic cells were performed. Read More

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December 2018

p53-Sensitive Epileptic Behavior and Inflammation in Hypomorphic Mice.

Front Genet 2018 27;9:581. Epub 2018 Nov 27.

Department of Biology and Biotechnology, Sapienza University of Rome, Rome, Italy.

Epilepsy is a complex clinical condition characterized by repeated spontaneous seizures. Seizures have been linked to multiple drivers including DNA damage accumulation. Investigation of epilepsy physiopathology in humans imposes ethical and practical limitations, for this reason model systems are mostly preferred. Read More

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November 2018

Primary pseudomyogenic hemangioendothelioma of bone: case report and review of the literature.

Pathologica 2018 Sep;110(2):96-101

Dermatopathologie Laboratory, Friedrichshafen, Germany.

Pseudomyogenic hemangioendothelioma (PMH) represents a multicentric recently characterized tumor type, generally presenting in young adults, of postulated vascular origin and intermediate malignancy. This entity tends to arise in the deep-seated dermal-subcutaneous locations, preferentially limited to one anatomic site, and may extend secondary to bone. PMH restricted to the skeletal system is rare. Read More

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September 2018

Role of hyperglycaemia in the relationship between serum osteocalcin levels and relative skeletal muscle index.

Clin Nutr 2018 Nov 30. Epub 2018 Nov 30.

Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China. Electronic address:

Background & Aims: Studies have shown that osteocalcin is involved in energy metabolism and is sufficient to prevent age-related muscle loss. The present study investigated the association of serum osteocalcin levels with muscle mass and the influence of metabolic factors on this association in humans.

Methods: A total of 1742 middle-aged and elderly subjects (median age: 61. Read More

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November 2018

Limited performance of subjective global assessment compared to computed tomography-determined sarcopenia in predicting adverse clinical outcomes in patients with cirrhosis.

Clin Nutr 2018 Nov 30. Epub 2018 Nov 30.

Division of Gastroenterology & Liver Unit, University of Alberta Hospital, Edmonton, Alberta, Canada. Electronic address:

Background & Aims: The subjective global assessment (SGA) is commonly used to assess nutritional status in patients with cirrhosis. Sarcopenia, a major component of malnutrition, is associated with survival in cirrhosis, and can be objectively diagnosed by computing the skeletal muscle index (SMI) using cross-sectional imaging. The aim of this study was to assess the prevalence of sarcopenia between SGA categories in patients with cirrhosis, and to determine their association with decompensation/mortality. Read More

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November 2018

Structural and functional properties of αβ-heterodimers of tropomyosin with myopathic mutations Q147P and K49del in the β-chain.

Biochem Biophys Res Commun 2018 Dec 10. Epub 2018 Dec 10.

A.N. Bach Institute of Biochemistry, Research Center of Biotechnology, Russian Academy of Sciences, Moscow, 119071, Russia; A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, 119234, Russia. Electronic address:

Tropomyosin (Tpm) is an α-helical coiled-coil actin-binding protein that plays a key role in the Ca-regulated contraction of striated muscles. Two Tpm isoforms, α (Tpm 1.1) and β (Tpm 2. Read More

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December 2018

Protein Prevents Dexamethasone-Induced Myotube Atrophy in C2C12 Myotubes.

Mar Drugs 2018 Dec 8;16(12). Epub 2018 Dec 8.

Institute of Fisheries Sciences, Pukyong National University, Busan 46041, Korea.

Glucocorticoids (GCs), which are endocrine hormones released under stress conditions, can cause skeletal muscle atrophy. This study investigated whether crude protein (PYCP) inhibits synthetic GCs dexamethasone (DEX)-induced myotube atrophy associated with proteolytic systems. Mouse skeletal muscle C2C12 myotubes were treated with DEX in the presence or absence of PYCP. Read More

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December 2018

The Primary Causes of Muscle Dysfunction Associated with the Point Mutations in Tpm3.12; Conformational Analysis of Mutant Proteins as a Tool for Classification of Myopathies.

Int J Mol Sci 2018 Dec 10;19(12). Epub 2018 Dec 10.

Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.

Point mutations in genes encoding isoforms of skeletal muscle tropomyosin may cause nemaline myopathy, cap myopathy (Cap), congenital fiber-type disproportion (CFTD), and distal arthrogryposis. The molecular mechanisms of muscle dysfunction in these diseases remain unclear. We studied the effect of the E173A, R90P, E150A, and A155T myopathy-causing substitutions in γ-tropomyosin (Tpm3. Read More

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December 2018

Prevalence and Correlates of Sarcopenia among Elderly CKD Outpatients on Tertiary Care.

Nutrients 2018 Dec 10;10(12). Epub 2018 Dec 10.

Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.

Background: Sarcopenia is a widespread concern in chronic kidney disease (CKD) as well in elderly patients and is one of the main reasons why low-protein diets for this population are controversial. The aim of this study was to assess the prevalence and correlates of sarcopenia among elderly male patients affected by CKD followed up in an outpatient nephrology clinic, where moderate protein restriction (0.6⁻0. Read More

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December 2018

Induced Pluripotent Stem Cells for Duchenne Muscular Dystrophy Modeling and Therapy.

Cells 2018 Dec 7;7(12). Epub 2018 Dec 7.

Institute of Histology and Embryology, Faculty of Medicine, Comenius University, Sasinkova 4, 811 08 Bratislava, Slovakia.

Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder, caused by mutation of the gene which encodes the protein dystrophin. This dystrophin defect leads to the progressive degeneration of skeletal and cardiac muscles. Currently, there is no effective therapy for this disorder. Read More

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December 2018

Bone Immune Response to Materials, Part I: Titanium, PEEK and Copper in Comparison to Sham at 10 Days in Rabbit Tibia.

J Clin Med 2018 Dec 7;7(12). Epub 2018 Dec 7.

Department of Prosthodontics, Faculty of Odontology, The Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.

Bone anchored biomaterials have become an indispensable solution for the restoration of lost dental elements and for skeletal joint replacements. However, a thorough understanding is still lacking in terms of the biological mechanisms leading to osseointegration and its contrast, unwanted peri-implant bone loss. We have previously hypothesized on the participation of immune mechanisms in such processes, and later demonstrated enhanced bone immune activation up to 4 weeks around titanium implants. Read More

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December 2018

Molecular and Functional Interaction of the Myokine Irisin with Physical Exercise and Alzheimer's Disease.

Molecules 2018 Dec 7;23(12). Epub 2018 Dec 7.

Department of Rehabilitation Science, Graduate School of Inje University, Gimhae 50834, Korea.

Irisin, a skeletal muscle-secreted myokine, produced in response to physical exercise, has protective functions in both the central and the peripheral nervous systems, including the regulation of brain-derived neurotrophic factors. In particular, irisin is capable of protecting hippocampus. Since this area is the region of the brain that is most susceptible to Alzheimer's disease (AD), such beneficial effect may inhibit or delay the emergence of neurodegenerative diseases, including AD. Read More

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December 2018

Molecular mechanisms in skeletal muscle underlying insulin resistance in lean women with polycystic ovary syndrome.

J Clin Endocrinol Metab 2018 Dec 13. Epub 2018 Dec 13.

Molecular Physiology Section, Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.

Context: Skeletal muscle molecular mechanisms underlying insulin resistance in women with polycystic ovary syndrome (PCOS) are poorly understood.

Objective: To provide insight into mechanisms regulating skeletal muscle insulin resistance in lean women with PCOS.

Participants And Methods: A hyperinsulinemic-euglycemic clamp with skeletal muscle biopsies was performed. Read More

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December 2018

CREB activation in hypertrophic chondrocytes is involved in the skeletal overgrowth in epiphyseal chondrodysplasia Miura type caused by activating mutations of natriuretic peptide receptor B.

Hum Mol Genet 2018 Dec 13. Epub 2018 Dec 13.

Department of Bone and Mineral Research, Research Institute, Osaka Women's and Children's Hospital, Osaka Prefectural Hospital Organization, Izumi, Osaka 594-1101, Japan.

Natriuretic peptide receptor B (NPRB) produces cyclic guanosine monophosphate (cGMP) when bound by C-type natriuretic peptide (CNP). Activating mutations in NPRB cause a skeletal overgrowth disorder, which has been named epiphyseal chondrodysplasia, Miura type (ECDM; OMIM #615923). Here we explored the cellular and molecular mechanisms for the skeletal overgrowth in ECDM using a mouse model in which an activating mutant NPRB is specifically expressed in chondrocytes. Read More

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December 2018

Influence of dietary vitamin D deficiency on bone strength, body composition, and muscle in ovariectomized rats fed a high-fat diet.

Nutrition 2018 Sep 5;60:87-93. Epub 2018 Sep 5.

Department of Food and Nutrition, Faculty of Human Sciences and Design, Japan Women's University, Tokyo, Japan. Electronic address:

Objective: Vitamin D deficiency is associated with a greater risk for osteoporosis and also influences skeletal muscle functions. The aim of this study was to investigate the influence of vitamin D restriction on ovariectomized (OVX) rats fed a high-fat diet.

Methods: Twenty-four 13-wk-old female rats were ovariectomized, and another 6 received a sham operation (Sham). Read More

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September 2018

GH replacement titrated to serum IGF-1 does not reduce concentrations of myostatin in blood or skeletal muscle.

Growth Horm IGF Res 2018 Dec 6;44:11-16. Epub 2018 Dec 6.

Waikato Clinical Campus, University of Auckland, Private Bag 3200, Hamilton 3240, New Zealand.

Objective: Traditional weight-based regimens of GH replacement are more effective at reversing the loss of skeletal muscle in GH-deficient adults than currently recommended regimens, where the dose of GH is increased to restore serum concentrations of IGF-1. While weight-based regimens increase concentrations of IGF-1 and decrease concentrations of myostatin, it is not known whether the reduced effectiveness of individually titrated GH regimens is due to ongoing hypersecretion of myostatin. Consequently, the aims of this study were to determine whether concentrations of myostatin in blood and skeletal muscle are increased in GH-deficient adults, and whether these concentrations are decreased by GH replacement regimens titrated to restore serum IGF-1. Read More

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December 2018

STAC proteins: The missing link in skeletal muscle EC coupling and new regulators of calcium channel function.

Biochim Biophys Acta Mol Cell Res 2018 Dec 10. Epub 2018 Dec 10.

Department of Physiology and Medical Physics, Medical University Innsbruck, Schöpfstraße 41, A6020 Innsbruck, Austria.

Excitation-contraction coupling is the signaling process by which action potentials control calcium release and consequently the force of muscle contraction. Until recently, three triad proteins were known to be essential for skeletal muscle EC coupling: the voltage-gated calcium channel Ca1.1 acting as voltage sensor, the SR calcium release channel RyR1 representing the only relevant calcium source, and the auxiliary Ca β subunit. Read More

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December 2018

Salvage or Solution: Alloplastic Reconstruction in Hemifacial Microsomia.

Cleft Palate Craniofac J 2018 Dec 13:1055665618817669. Epub 2018 Dec 13.

4 American Craniofacial Associates, Athens, Greece.

Introduction:: Skeletal reconstruction in severe grades of hemifacial microsomia (HFM) continues to be challenging. Traditional techniques of autografts and osseous distraction for reconstruction of the glenoid fossa, condyle, and ramus can fall short of expectations and can create new problems. This intercontinental study analyzes the role of alloplastic skeletal rehabilitation in severe HFM. Read More

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December 2018

Mesencephalic astrocyte-derived neurotropic factor is an important factor in chondrocyte ER homeostasis.

Cell Stress Chaperones 2018 Dec 12. Epub 2018 Dec 12.

Institute of Genetic Medicine, International Centre for Life, Newcastle University, Newcastle Upon Tyne, NE1 3BZ, UK.

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER) resident protein that can be secreted due to an imperfect KDEL motif. MANF plays a cytoprotective role in several soft tissues and is upregulated in conditions resulting from intracellular retention of mutant protein, including two skeletal diseases, metaphyseal chondrodysplasia, Schmid type (MCDS) and multiple epiphyseal dysplasia (MED). The role of MANF in skeletal tissue homeostasis is currently unknown. Read More

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December 2018

The association of back muscle strength and sarcopenia-related parameters in the patients with spinal disorders.

Eur Spine J 2018 Dec 12. Epub 2018 Dec 12.

Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, Japan.

Purpose: To evaluate the correlations between back muscle strength, trunk muscle mass, and sarcopenia-related parameters in patients with spinal disorders.

Methods: This cross-sectional observational study included 230 consecutive patients with spinal disorders who visited our outpatient clinic (age range 65-92 years). We measured back muscle strength, handgrip strength, gait speed, and appendicular and trunk skeletal muscle mass using bioimpedance analysis. Read More

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December 2018

Morphometric study of the primary ossification center of the fibular shaft in the human fetus.

Surg Radiol Anat 2018 Dec 12. Epub 2018 Dec 12.

Department of Otolaryngology and Oncology, The Ludwik Rydygier Collegium Medicum in Bydgoszcz, The Nicolaus Copernicus University in Toruń, Toruń, Poland.

Purposes: Precise morphometric data on the development of ossification centers in human fetuses may be useful in the early detection of skeletal dysplasias associated with delayed ossification center development and mineralization. The present study was performed to quantitatively examine the primary ossification center of the fibular shaft with respect to its linear, planar and volumetric parameters.

Materials And Methods: Using methods of CT, digital-image analysis (Osirix 3. Read More

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December 2018

Surgical management of patellofemoral instability. I. Imaging considerations.

Skeletal Radiol 2018 Dec 12. Epub 2018 Dec 12.

Department of Radiology, The Royal National Orthopaedic Hospital NHS Trust, Brockley Hill, Stanmore, Middlesex, HA7 4LP, UK.

The patellofemoral joint is a complex joint that relies on both bone and soft tissues for its stability. Dysfunction of the patellofemoral joint, whether pain or instability, is a common cause of medial consultation. Thorough clinical and imaging assessment is important for managing these patients, who may require a combination of a bony and soft tissue surgical procedure. Read More

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December 2018

Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling.

F1000Res 2018 27;7. Epub 2018 Nov 27.

Department of Cancer Biology and Therapeutics, John Curtin School of Medical Research, 131 Garran Road, The Australian National University, Acton, ACT, 2601, Australia.

The ryanodine receptor calcium release channel is central to cytoplasmic Ca signalling in skeletal muscle, the heart, and many other tissues, including the central nervous system, lymphocytes, stomach, kidney, adrenal glands, ovaries, testes, thymus, and lungs. The ion channel protein is massive (more than 2.2 MDa) and has a structure that has defied detailed determination until recent developments in cryo-electron microscopy revealed much of its structure at near-atomic resolution. Read More

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November 2018

An embryo-fetal development toxicity study with dimethylaminoethyl ginkgolide B in rats and rabbits.

Toxicol Res (Camb) 2018 Nov 28;7(6):1225-1235. Epub 2018 Aug 28.

School of Pharmaceutical Sciences , Nanjing Tech University , Nanjing , 211816 , China . Email: ; Email:

(a herbal product) has long been used in traditional Chinese medicine to treat cerebrovascular and cardiovascular diseases. Ginkgolide B is one of the important pharmacologically active components of . Dimethylaminoethyl ginkgolide B (a novel ginkgolide B derivative) has been developed to overcome the poor water-solubility of natural drugs and to achieve higher bioavailability. Read More

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November 2018

Fluorescence enhancement of a ligand-activated fluorescent protein induced by collective noncovalent interactions.

Chem Sci 2018 Nov 8;9(44):8325-8336. Epub 2018 Oct 8.

Center for Molecular Spectroscopy and Dynamics , Institute for Basic Science (IBS) , Korea University , Seoul 02841 , Republic of Korea . Email: ; Email:

Fluorescent proteins contain an internal chromophore constituted of amino acids or an external chromophore covalently bonded to the protein. To increase their fluorescence intensities, many research groups have attempted to mutate amino acids within or near the chromophore. Recently, a new type of fluorescent protein, called UnaG, in which the ligand binds to the protein through many noncovalent interactions was discovered. Read More

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November 2018

Comparative study of the proliferative ability of skeletal muscle satellite cells under microwave irradiation in fractures with titanium alloy internal fixation in rabbits.

Exp Ther Med 2018 Dec 1;16(6):4357-4366. Epub 2018 Oct 1.

Department of Rehabilitation, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China.

The aim of the present study was to investigate the proliferation of skeletal muscle satellite cells (MSCs) under different amounts of microwave irradiation in fractures with titanium alloy internal fixation. A total of 45 male New Zealand adult white rabbits were used to establish a femoral shaft fracture and titanium alloy internal fixation model. The rabbits were randomly divided into the control group (group A) and the experimental groups (groups B and C). Read More

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December 2018

Protein-rich extract of larvae alleviated metabolic disorder in STZ-induced type 2 diabetic rat model via hepatoprotective and pancreatic β-cell protective activities.

J Biosci 2018 Dec;43(5):969-983

Guangdong Key Laboratory of Pharmaceutical Bioactive Substances, Guangzhou 510006, Guangdong, China.

The study was designed to explore the beneficial effect of Musca domestica larvae extract (MDLE) on a metabolic disorder using a diabetic rat model. Streptozotocin-induced diabetic rats were treated with or without MDLE. Blood glucose, insulin levels, lipid profiles, and oxidative stress markers were measured. Read More

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December 2018

Thermosensitive, fast gelling, photoluminescent, highly flexible, and degradable hydrogels for stem cell delivery.

Acta Biomater 2019 Jan 26;83:96-108. Epub 2018 Oct 26.

Department of Materials Science and Engineering, The Ohio State University, 2041 College Road, Columbus, OH, USA; Department of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO 63130, USA. Electronic address:

Stem cell therapy is a promising approach to regenerate ischemic cardiovascular tissues yet experiences low efficacy. One of the major causes is inferior cell retention in tissues. Injectable cell carriers that can quickly solidify upon injection into tissues so as to immediately increase viscosity have potential to largely improve cell retention. Read More

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January 2019

Frequency of Osteoporosis and Vertebral Fractures in Chronic Obstructive Pulmonary Disease (COPD) Patients.

Arch Bronconeumol 2018 Dec 9. Epub 2018 Dec 9.

Escola Paulista de Medicina at the Federal University of São Paulo (EPM/Unifesp) , São Paulo (SP), Brazil. Electronic address:

Background: Osteoporosis is a systemic skeletal disease characterized by low bone mass and/or microarchitectural deterioration of bone. Osteoporosis is a risk factor for fractures specially in patients with advanced COPD. The aim of this cross-sectional study was to determine the frequency of osteoporosis and vertebral fracture in COPD patients. Read More

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December 2018

Non-ossifying fibroma with a pathologic fracture in a 12-year-old girl with tricho-rhino-phalangeal syndrome: a case report.

BMC Med Genet 2018 Dec 12;19(1):211. Epub 2018 Dec 12.

Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, 55# Zhenhai Road, Xiamen, 361003, China.

Background: Tricho-rhino-phalangeal syndrome (TRPS) is a rare autosomal dominant genetic disorder characterized by distinctive craniofacial and skeletal abnormalities, while non-ossifying fibroma (NOF) is a common benign bone tumour in children and adolescents. To date, no case of TRPS coexisting with NOF has been reported. This report presents a 12-year-old girl who had the characteristic features of tricho-rhino-phalangeal syndrome and non-ossifying fibroma with a fibula fracture. Read More

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December 2018

Associations of body fat and skeletal muscle with hypertension.

J Clin Hypertens (Greenwich) 2018 Dec 7. Epub 2018 Dec 7.

Human Nutrition, School of Medicine, University of Glasgow, Glasgow, UK.

Hypertension is known to be associated with obesity, while its relationship to skeletal muscle, SM (SM; a marker of general health and body function), remains uncertain. We analyzed population-based data of 22 591 men (mean age: 51.6 ± 16. Read More

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December 2018

Diabetes, body fat, skeletal muscle, and hypertension: The ominous chiasmus?

J Clin Hypertens (Greenwich) 2018 Dec 7. Epub 2018 Dec 7.

Department of Medicine, Albert Einstein College of Medicine, Montefiore University Hospital, New York, New York.

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December 2018

Magnetic cell delivery for the regeneration of musculoskeletal and neural tissues.

Regen Ther 2018 Dec 2;9:116-119. Epub 2018 Nov 2.

President of Hiroshima University, Higashihiroshima, Japan.

Magnetic targeting is a cell delivery system using the magnetic labeling of cells and the magnetic field; it has been developed for minimally invasive cell transplantation. Cell transplantation with both minimal invasiveness and high efficacy on tissue repair can be achieved by this system. Magnetic targeting has been applied for the transplantation of bone marrow mesenchymal stem cells, blood CD133-positive cells, neural progenitor cells, and induced pluripotent stem cells, and for the regeneration of bone, cartilage, skeletal muscles, and the spinal cord. Read More

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December 2018

A novel, flexible and automated manufacturing facility for cell-based health care products: Tissue Factory.

Regen Ther 2018 Dec 19;9:89-99. Epub 2018 Sep 19.

Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University (TWIns), 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.

Introduction: Current production facilities for Cell-Based Health care Products (CBHPs), also referred as Advanced-Therapy Medicinal Products or Regenerative Medicine Products, are still dependent on manual work performed by skilled workers. A more robust, safer and efficient manufacturing system will be necessary to meet the expected expansion of this industrial field in the future. Thus, the 'flexible Modular Platform (fMP)' was newly designed to be a true "factory" utilizing the state-of-the-art technology to replace conventional "laboratory-like" manufacturing methods. Read More

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December 2018

Human iPSC Models to Study Orphan Diseases: Muscular Dystrophies.

Curr Stem Cell Rep 2018 4;4(4):299-309. Epub 2018 Oct 4.

3Houston Methodist Neurological Institute and Research Institute, 6670 Bertner Ave R11-117, Houston, TX USA.

Purpose Of Review: Muscular dystrophies (MDs) are a spectrum of muscle disorders, which are caused by a number of gene mutations. The studies of MDs are limited due to lack of appropriate models, except for Duchenne muscular dystrophy (DMD), myotonic dystrophy type 1 (DM1), facioscapulohumeral muscular dystrophy (FSHD), and certain type of limb-girdle muscular dystrophy (LGMD). Human induced pluripotent stem cell (iPSC) technologies are emerging to offer a useful model for mechanistic studies, drug discovery, and cell-based therapy to supplement in vivo animal models. Read More

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October 2018

Vitamin D deficiency was common in all patients at a Swedish primary care centre, but more so in patients born outside of Europe.

Z Gesundh Wiss 2018 27;26(6):649-652. Epub 2018 Mar 27.

1Division of Family Medicine and Primary Care, Department NVS, Karolinska Institutet, Alfred Nobels allé 23, SE-141 83 Huddinge, Sweden.

Background: Vitamin D is associated with extra-skeletal processes, and vitamin D deficiency might contribute to the development of chronic diseases.

Aim: To investigate vitamin D levels in an unselected patient population at a Swedish suburban primary care centre.

Methods: Vitamin D levels were assessed in 102 patients aged 20 to 65 years visiting the primary care centre, independent of cause of visit, during 2 weeks in January 2014. Read More

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Chronic kidney disease: considerations for monitoring skeletal muscle health and prescribing resistance exercise.

Clin Kidney J 2018 Dec 16;11(6):822-831. Epub 2018 Jul 16.

Renal Service, Veterans Affairs Medical Center, Washington, DC, USA.

Skeletal muscle wasting has gained interest as a primary consequence of chronic kidney disease (CKD) due to the relationship between skeletal muscle mass, mortality and major adverse cardiovascular events in this population. The combination of reductions in physical function, skeletal muscle performance and skeletal muscle mass places individuals with CKD at greater risk of sarcopenia. Therefore the monitoring of skeletal muscle composition and function may provide clinical insight into disease progression. Read More

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December 2018

Satellite cell function, intramuscular inflammation and exercise in chronic kidney disease.

Clin Kidney J 2018 Dec 30;11(6):810-821. Epub 2018 Jul 30.

Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.

Skeletal muscle wasting is a common feature of chronic kidney disease (CKD) and is clinically relevant due to associations with quality of life, physical functioning, mortality and a number of comorbidities. Satellite cells (SCs) are a population of skeletal muscle progenitor cells responsible for accrual and maintenance of muscle mass by providing new nuclei to myofibres. Recent evidence from animal models and human studies indicates CKD may negatively affect SC abundance and function in response to stimuli such as exercise and damage. Read More

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December 2018

The Possible Pathophysiological Outcomes and Mechanisms of Tourniquet-Induced Ischemia-Reperfusion Injury during Total Knee Arthroplasty.

Oxid Med Cell Longev 2018 5;2018:8087598. Epub 2018 Nov 5.

Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Ischemia and reperfusion (I/R) injury induced by tourniquet (TQ) application leads to the release of both oxygen free radicals and inflammatory cytokines. The skeletal muscle I/R may contribute to local skeletal muscle and remote organ damage affecting outcomes after total knee arthroplasty (TKA). The aim of the study is to summarize the current findings associated with I/R injury following TKA using a thigh TQ, which include cellular alterations and protective therapeutic interventions. Read More

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November 2018

Electroacupuncture Mitigates Skeletal Muscular Lipid Metabolism Disorder Related to High-Fat-Diet Induced Insulin Resistance through the AMPK/ACC Signaling Pathway.

Evid Based Complement Alternat Med 2018 7;2018:7925842. Epub 2018 Nov 7.

Traditional Therapy Department of Fangchun, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510000, China.

The aim of this work is to investigate the effect of electroacupuncture (EA) on insulin sensitivity in high-fat diet (HFD) induced insulin resistance (IR) rats and to evaluate expression of AMPK/ACC signaling components. Thirty-two male Sprague-Dawley rats were randomized into control group, HFD group, HFD+Pi (oral gavage of pioglitazone) group, and HFD+EA group. Acupuncture was subcutaneously applied to Zusanli (ST40) and Sanyinjiao (SP6). Read More

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November 2018

EGCG Reduces Obesity and White Adipose Tissue Gain Partly Through AMPK Activation in Mice.

Front Pharmacol 2018 22;9:1366. Epub 2018 Nov 22.

Key Laboratory of Puer Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming, China.

(-)-Epigallocatechin-3-gallate (EGCG), which is the most abundant catechin in green tea, has many potential health benefits, including decreased weight gain and/or adipose tissue weight. Suggested mechanisms for body weight reduction by EGCG include: (1) a decrease in calorie intake and (2) activation of AMPK in liver, skeletal muscle, and white adipose tissue. However, only one study supports the AMPK hypothesis. Read More

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November 2018

Paraneoplastic syndrome - a rare but treatable cause of non-thyroid-related extraocular muscle enlargement.

Authors:
S Kumar T Diamond

Orbit 2018 Dec 7:1-6. Epub 2018 Dec 7.

b Professor in Endocrinology , St George Public Hospital , Kogarah , NSW , Australia.

Paraneoplastic syndrome is a rare but reversible cause of non-thyroid-related extraocular muscle enlargement. We present a 71-year-old lady with diplopia, restricted eye movements, suppressed thyroid-stimulating hormone and enlargement of all extraocular muscles while on thyroxine replacement for hypothyroidism. She had distant history of metastatic breast cancer treated with chemotherapy, surgical resection and tamoxifen. Read More

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December 2018